https://ntp.niehs.nih.gov/go/3552

TDMS Study 05084-01 Pathology Tables

NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97
Route: DOSED FEED                                                                                                 Time: 07:39:35
       Facility:  TSI Mason Research
       Chemical CAS #:  8024-37-1
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
                                                              Page   1
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|             
                                           | 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           3                              |             
      Parasite Metazoan                    | 1     1  1  1     1  1  1     1  1        1  1              1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           2                              |             
      Parasite Metazoan                    |       1  1                             2                             1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           3                              |             
      Parasite Metazoan                    |       1              2  1                    1                 1     1   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           4                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           3                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     | 1     1        1  1  1  1     1  1  1  1     2     2        2  1     1   |             
      Clear Cell Focus                     | 1        1     1              2  1  1        3                           |             
      Eosinophilic Focus                   |                                              2                           |             
      Fatty Change                         |    3        3                                   1                        |             
      Hepatodiaphragmatic Nodule           |                      X              X                       X  X         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       1        1  1           2           1  2  1     1        1  1  1  1|             
      Mixed Cell Focus                     |                   2                                               2      |             
      Necrosis, Coagulative                |                                           2     1                        |             
      Bile Duct, Hyperplasia               |          2  1        1        1     1                 1     2        1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Fibrosis                             |       2                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       3                                                                  |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             1  1                       1  1  1              1  1     1  1|             
      Vacuolization Cytoplasmic            |    1                                      3     2                        |             
      Acinus, Atrophy                      |    1     1  1  1                    1  1  2  2              1  1  1  1  1|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|             
                                           | 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                1     1           1                 1                     |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |                   1           1        1  1        1                     |             
      Parotid Gland, Atrophy               |                                                                          |             
      Parotid Gland, Submandibular Gland,  |                                                                          |             
           Inflammation, Chronic Active    |                                                                          |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                       1                  |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Sublingual Gland, Metaplasia,        |                                                                          |             
          Squamous                         |                                                       1                  |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                         1  1                                             |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                      1           1     1           1  1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |    1                                                                     |             
      Ulcer                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Dilatation                   | 1  1  1  1  1  1  1  1           1  2  1     1     1        1  1  1  2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  1     1  2  2  1  1  2  2  2  2  1  1     2  2  1  2  2  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1        1  1  1     1  2  1  2  1     1     2  1  1  1  1  2     1|             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Hyperplasia                          |    2  2                       2              1  2  2           3         |             
      Vacuolization Cytoplasmic            | 1  2  2           1  2           1              3                 2  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|             
                                           | 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 1                                   2                                    |             
      Pars Distalis, Cyst                  |          2  2  2  2  2  2  1  2        2  1     1        1  1        2  2|             
      Pars Distalis, Hyperplasia           | 1        1     2  1  2  2     2              2     2        1  4         |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               1                                          |             
      C-Cell, Hyperplasia                  |                      2  1     2     1        1     1  1              1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1           1                             2         |             
      Inflammation, Chronic                |                                                                         1|             
      Inflammation, Chronic Active         |    1  1     1  1  1  1        1        1     1  1     1     1  2  2  1   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    4  3                                                                  |             
      Hemorrhage                           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                     3                                2   |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         | 1                                                                        |             
      Cervix, Cyst                         |                                                                4         |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia             |                   1                          1     2           3         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                            2                                            1|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|             
                                           | 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +                                                                     |             
      Hemorrhage                           |                                                                          |             
      Sinus, Ectasia                       | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |                         1  1                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |          4  3                                   3                        |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                  3     3           2                     |             
      Hyperplasia                          | 2  3  4  3  3  3  3  2     2  3  3  4  2  3  3  3  3     1  4  1  3  3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Foot, Acanthosis                     |                                                             2            |             
      Foot, Hyperkeratosis                 |                                                             3            |             
      Foot, Inflammation, Chronic Active   |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
      Cranium, Osteopetrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Infiltration Cellular, Histiocyte    |             1  1     1  1              1           1  1  1     1         |             
      Metaplasia, Osseous                  |                                                             1            |             
      Alveolar Epithelium, Hyperplasia     |                1                 3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|             
                                           | 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Artery, Mineralization               |    1           1     1  1  1           1     1  1  1  1     1  1  1  1   |             
      Artery, Muscularis, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1  1                             1  1  1     2        1  1  1  1   |             
      Metaplasia, Squamous                 |                                                       2                  |             
      Lumen, Inflammation, Acute           |                                                       2                  |             
      Mucosa, Ulcer                        |                                                                          |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                       2                  |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                          1               |             
      Submucosa, Glands, Inflammation,     |                                                                          |             
           Acute                           |                                                          1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                 +                                          |             
      Cataract                             |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Inflammation, Chronic Active |                               2                                          |             
      Cornea, Neovascularization           |                               3                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                           2                              |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 1  2  2  2  1  2  2  2     1  2  3  1  2     2  1  1  1  1  2  1  1  2  1|             
      Renal Tubule, Mineralization         | 1                                      1                                 |             
      Transitional Epithelium, Hyperplasia | 1     1        1  1                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1                                                         |             
      Subserosa, Mineralization            |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|             
                                           | 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
      Parasite Metazoan                    | 1                 1        1     1     1              2     1        1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
      Parasite Metazoan                    |       1                 1        1              1     1                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
      Parasite Metazoan                    |                1                                   1                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                                        |             
      Autolysis                            |                                     3                                    |             
      Basophilic Focus                     | 1  1           1              1        1  1  1  1              1  1  1   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                              1                           |             
      Fatty Change                         |                      2                                2  2               |             
      Hepatodiaphragmatic Nodule           |             X              X                                X     X      |             
      Inflammation, Chronic                |          1  1           2                 1                              |             
      Inflammation, Chronic Active         |    1           1  1           1                          1           2  1|             
      Mixed Cell Focus                     |                   1                                               1      |             
      Necrosis, Coagulative                |          1     1                                                     1   |             
      Bile Duct, Hyperplasia               |             1                                               1     1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                                   +|             
      Fibrosis                             |             2                                                           2|             
      Inflammation, Chronic                |             2                                                            |             
      Inflammation, Chronic Active         |                                                                         2|             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1           1                 1                              |             
      Inflammation, Chronic Active         | 1  1           1  1                          1  1  1     1     1  1      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Acinus, Atrophy                      |                1  1  4           1              2  2        2  1  1      |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|             
                                           | 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |       1                                                                  |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |                                                 1           1     1      |             
      Parotid Gland, Atrophy               |                                                                          |             
      Parotid Gland, Submandibular Gland,  |                                                                          |             
           Inflammation, Chronic Active    |                                                                          |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                    1                     |             
      Sublingual Gland, Metaplasia,        |                                                                          |             
          Squamous                         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |             1                                                            |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |       1        1                 1              1           1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       2              2                                                   |             
      Hyperplasia, Squamous                |       3              2                                                   |             
      Ulcer                                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     4                                    |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Dilatation                   | 1  2  2        1  1  2        1        1     1  1  1  1  1  2  2  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  2  2  1  1  2  2  2  2  1  1  2  3  1  1  2  2  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1     2  1     2     1  1  2     1  1  1     1  1     1     1  2  1  2|             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia                          |                                                 2              1         |             
      Vacuolization Cytoplasmic            | 2     1        1     3        1  1           1  1     1     1        1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|             
                                           | 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      3                       2                           |             
      Pars Distalis, Cyst                  |          1     1  2  3     2              1  2  2  2     1  2  2     2   |             
      Pars Distalis, Hyperplasia           | 2                                               1  2     1           1   |             
      Pars Distalis, Pigmentation          |             1                                                            |             
      Pars Intermedia, Angiectasis         |       2                                                                  |             
      Pars Intermedia, Cyst                |                                           1                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      C-Cell, Hyperplasia                  | 1                 1  1     1  1        1  1  1  1  1  1        1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                2  2      |             
      Inflammation, Chronic                |                         1  1              1                              |             
      Inflammation, Chronic Active         | 1     1        1  1           2        1        1     1        2  1      |             
      Duct, Dilatation                     |    2                 2                                   2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                      2                 2  2              2              1|             
      Inflammation, Acute                  |                                        2                                 |             
      Pigmentation                         |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Cyst                    |          1                                                               |             
      Endometrium, Hyperplasia             |                   1           1                       1                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |             2           2  1                                             |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Mediastinal, Pigmentation            |                                           1                              |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |          2                                                               |             
      Pancreatic, Pigmentation             |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|             
                                           | 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                         +                                   +            |             
      Hemorrhage                           |                         3                                                |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  2  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |          1  1           1  1              1                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              1                           |             
      Autolysis                            |                                     3                                    |             
      Depletion Lymphoid                   |                      2              2                 4     1        1   |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                   3           2                                          |             
      Infiltration Cellular, Histiocyte    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Cyst                                 |       1                                1                       1         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 3  2  3  1  2  3  3  3  2  2  3  2  2  2  2  2  3  2  3  1  2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    4                                                                     |             
      Foot, Acanthosis                     | 2                                                                        |             
      Foot, Hyperkeratosis                 | 2                                                                        |             
      Foot, Inflammation, Chronic Active   | 2                                                                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         | 3                                                                       2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                             2            |             
      Cranium, Osteopetrosis               | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                         2|             
      Hydrocephalus                        |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1              1        1              1  1           3        1   |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|             
                                           | 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Artery, Mineralization               |    1  1           1           1     1        1  1  1              1     1|             
      Artery, Muscularis, Hyperplasia      |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1     1        1  1           1  1  2  4        1  1  1     1     1  1  1|             
      Metaplasia, Squamous                 |                                        4                                 |             
      Lumen, Inflammation, Acute           |                                                                          |             
      Mucosa, Ulcer                        |                                     1                                    |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Submucosa, Glands, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          M                       +     +              +  +               |             
      Cataract                             |                                                                          |             
      Phthisis Bulbi                       |                                  3                                       |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Neovascularization           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
      Hydronephrosis                       |                                                          3               |             
      Nephropathy                          | 2  2  4  1  1  2  1  2  1  1  2  2  2  1  1  2  2  2  2  2  2  2  1  2  2|             
      Renal Tubule, Mineralization         |          1                 1                                             |             
      Transitional Epithelium, Hyperplasia |       1                                                                 1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1                                                  1      |             
      Subserosa, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1|                                            |            |
                                           | 4| 4| 5| 4| 8| 5| 7| 7| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
      Parasite Metazoan                    | 1                 1                                                      |     22  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  2.5|
      Parasite Metazoan                    |                   1                                                      |     10  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
      Parasite Metazoan                    |                                                                          |      8  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Autolysis                            |                                                                          |      1  3.0|
      Basophilic Focus                     | 1  1  2           1  1     1                                             |     32  1.1|
      Clear Cell Focus                     |                      1                                                   |      8  1.4|
      Eosinophilic Focus                   |                                                                          |      2  1.5|
      Fatty Change                         |             1     2     2                                                |      9  2.0|
      Hepatodiaphragmatic Nodule           | X     X                                                                  |     10     |
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Inflammation, Chronic Active         |       1  1  1  1                                                         |     23  1.1|
      Mixed Cell Focus                     |                X                                                         |      5  1.5|
      Necrosis, Coagulative                |       1        1                                                         |      7  1.1|
      Bile Duct, Hyperplasia               |       1              1  2  1                                             |     16  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   5        |
      Fibrosis                             |                   2                                                      |      4  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                   2                                                      |      3  2.3|
      Necrosis, Liquifactive               |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Chronic Active         | 1              1  1  2     2                                             |     24  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1|                                            |            |
                                           | 4| 4| 5| 4| 8| 5| 7| 7| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            |                         1                                                |      4  1.8|
      Acinus, Atrophy                      |                   1        2                                             |     24  1.4|
      Acinus, Hyperplasia                  |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                   2                                                      |      6  1.2|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     |                      1                                                   |      1  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             | 1  1     1        1                                                      |     12  1.0|
      Parotid Gland, Atrophy               |                   1                                                      |      1  1.0|
      Parotid Gland, Submandibular Gland,  |                                                                          |            |
           Inflammation, Chronic Active    |             1                                                            |      1  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic Active                   |       1                                                                  |      2  1.0|
      Sublingual Gland, Metaplasia,        |                                                                          |            |
          Squamous                         |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      3  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  | 1  1     1     1  1  1                                                   |     16  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |                                                                          |      3  2.0|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  4.0|
      Metaplasia, Squamous                 | 2                                                                        |      1  2.0|
      Mucosa, Dilatation                   | 2  2     2  1  1  2  2  1  1                                             |     44  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  2  2  2  1  2  2  1  1  1                                             |     58  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1|                                            |            |
                                           | 4| 4| 5| 4| 8| 5| 7| 7| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 2  2  1  2  1     1  1     2                                             |     44  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |          2     2  1                                                      |     12  1.8|
      Vacuolization Cytoplasmic            |                      1                                                   |     22  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                      1                                                   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                3           3                                             |      6  2.3|
      Pars Distalis, Cyst                  | 2                       1                                                |     30  1.7|
      Pars Distalis, Hyperplasia           | 2              2        3                                                |     19  1.8|
      Pars Distalis, Pigmentation          |                                                                          |      1  1.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  | 1  1  1  1  1  1  1  1  1  1                                             |     33  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                            2                                             |      7  1.6|
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Inflammation, Chronic Active         | 1  2  1  1        1  1  1                                                |     32  1.2|
      Duct, Dilatation                     |             2                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |          3                                                               |      8  2.1|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Cervix, Cyst                         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1|                                            |            |
                                           | 4| 4| 5| 4| 8| 5| 7| 7| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Cyst                    |                                                                          |      1  1.0|
      Endometrium, Hyperplasia             |                                                                          |      7  1.4|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Hemorrhage              |                                                                          |      5  1.6|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                                                                          |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   4        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Sinus, Ectasia                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1                                             |     60  1.0|
      Pigmentation                         |                                                                          |      7  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Autolysis                            |                                                                          |      1  3.0|
      Depletion Lymphoid                   | 1     1                 3                                                |     11  2.3|
      Fibrosis                             |       4                                                                  |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  I  +  +  +                                             |  51        |
      Cyst                                 |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Galactocele                          |                                                                          |      3  2.7|
      Hyperplasia                          | 2  3  2  3  2  4  2  2  2  3                                             |     57  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Abscess                              |                                                                          |      1  4.0|
      Foot, Acanthosis                     |                                                                          |      2  2.0|
      Foot, Hyperkeratosis                 |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1|                                            |            |
                                           | 4| 4| 5| 4| 8| 5| 7| 7| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Foot, Inflammation, Chronic Active   |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Hyperostosis                |                                                                          |      1  2.0|
      Cranium, Osteopetrosis               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Gliosis                              |                                                                          |      1  2.0|
      Hydrocephalus                        |             2        2                                                   |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |          4                                                               |      1  4.0|
      Infiltration Cellular, Histiocyte    | 1        1                                                               |     19  1.1|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                2                                                         |      4  2.0|
      Artery, Mineralization               | 1           1     1     1                                                |     28  1.0|
      Artery, Muscularis, Hyperplasia      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         | 1  2        1                                                            |     28  1.2|
      Metaplasia, Squamous                 |                                                                          |      2  3.0|
      Lumen, Inflammation, Acute           |                                                                          |      1  2.0|
      Mucosa, Ulcer                        |                                                                          |      1  1.0|
      Mucosa, Submucosa, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Submucosa, Glands, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +        +                                             |   9        |
      Cataract                             |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1|                                            |            |
                                           | 4| 4| 5| 4| 8| 5| 7| 7| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Phthisis Bulbi                       |          4                                                               |      2  3.5|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Cornea, Neovascularization           |                   1                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  2.5|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy                          | 2  2  2  2  2  2  2  3  1  2                                             |     58  1.7|
      Renal Tubule, Mineralization         |       1                                                                  |      5  1.0|
      Transitional Epithelium, Hyperplasia |                   1                                                      |      7  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      3  1.0|
      Subserosa, Mineralization            |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|             
                                           | 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Parasite Metazoan                    |    1  1     1                          1                       1  1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    2                     |             
      Parasite Metazoan                    |    1        1        1                 1        1              1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    2                     |             
      Parasite Metazoan                    | 1        2        1  1                          1                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    2                    2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1        1     1  1  1  1     1  1  1        1     1        1     1  1   |             
      Clear Cell Focus                     |                      1  2                                                |             
      Cytoplasmic Alteration               | 2                                                                        |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |             1              3     1  1                          1  2     3|             
      Fibrosis                             |                   2                                                      |             
      Hepatodiaphragmatic Nodule           |       X  X                                                     X  X      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Chronic Active         | 1        1        1  1           1                          1     1  1   |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                 2           1            |             
      Necrosis, Coagulative                |                               2                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               |    1  2     1  1              1  2  1        1     1        1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fibrosis                             |                      2                                                   |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Ectopic Liver                        |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|             
                                           | 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |          1     1  1  1        1  1                 1        1            |             
      Pigmentation                         |                      1                                                   |             
      Vacuolization Cytoplasmic            |             2                                      2           2         |             
      Acinus, Atrophy                      |    2  1  1     1  1  1     1     1  4           1           1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Sublingual Gland, Hyperplasia  |                                                                          |             
      Duct, Sublingual Gland, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                      1                                                   |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             | 1        1        1  1                          2           2  2     1   |             
      Parotid Gland, Atrophy               |                                                                          |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                      1                                                   |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  | 1        1           1              1           1           1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                         1|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                         1|             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    2                     |             
      Fibrosis                             |             1                                                            |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                                                   1      |             
      Mucosa, Dilatation                   | 1  2  2  1  1  1  1  1     1  2  1  1        1  1  1        1  1     1  1|             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
      Hyperplasia, Squamous                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  2  1  2  1  1     1  2  1  1        1  1  2        1  2  1  1  1|             
      Atrium, Thrombosis                   |                                                 1              4         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|             
                                           | 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Angiectasis                          | 1        1     2  1  2           2  1        1  1           1  1  1  1  1|             
      Autolysis                            |                                                                          |             
      Congestion                           |    2  2                                                                  |             
      Hematopoietic Cell Proliferation     |                1                                                         |             
      Hyperplasia                          |                1  1                                1        1  2         |             
      Vacuolization Cytoplasmic            | 1  2     1                 2        2                          2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                1         |             
      Pars Distalis, Cyst                  |    1        1     1        1  1     1        1              2  2     2   |             
      Pars Distalis, Hyperplasia           |    1        3  1  2  2        1     2        2              2     2  1   |             
      Pars Intermedia, Angiectasis         |                                                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1  1  1     1  1              1           1              1         |             
      Follicular Cell, Cyst                |                                     2                                    |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia                          |          3           2                                                   |             
      Inflammation, Chronic                |                                        2  1                              |             
      Inflammation, Chronic Active         |    1           1  1  1                       1              1  1         |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Periovarian Tissue, Cyst             |                                        4                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                     1                                    |             
      Inflammation, Acute                  |             2        4                       3                           |             
      Cervix, Cyst                         |                      4                       4                           |             
      Endometrium, Hyperplasia             |                2                                                         |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|             
                                           | 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Exudate                              |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Fibrosis                  |                                                                          |             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Mediastinal, Hemorrhage              |          2                                                               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell| 2                                                                        |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +                    +                                      +|             
      Hyperplasia, Lymphoid                |                                  1                                       |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |                         1              1  1           1  1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Depletion Lymphoid                   |    2  3     3              4        3        2     4           3        3|             
      Fibrosis                             |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Galactocele                          |                X                                                         |             
      Hyperplasia                          | 3  2  3  3  4  3  3  2     2  3  3  2        1  3  3        2  4  1  1  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Acanthosis                           |       2                                                                  |             
      Hyperkeratosis                       |       1                                                                  |             
      Hyperplasia, Basal Cell              |       1                                                                  |             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |       1                                                                  |             
      Cranium, Osteopetrosis               | 2                                                                        |             
      Sternum, Osteopetrosis               | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|             
                                           | 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Infarct                              |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |          1     1                    1        1              1            |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                2         |             
      Artery, Mineralization               |             1  1                    1        1  1              1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  3        1                    1              3  1           1     1  1|             
      Metaplasia, Squamous                 |    3                                                           2         |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Ulcer                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                          +        +                                   +|             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Chronic Active | 3                                                                        |             
      Cornea, Neovascularization           | 2                                                                        |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          | +                                                                        |             
      Inflammation, Chronic                | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +  +     +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3  2  1  2  1  1  2  2     1  2  2  1        1  1  1  1     1  1  2  1  1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                                          |             
      Transitional Epithelium, Hyperplasia |    1                                1                             1      |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     M  +  +  +        +  +  +        +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|             
                                           | 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2,000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Parasite Metazoan                    |                   1           1              1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Parasite Metazoan                    |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
      Parasite Metazoan                    |                               1                             1            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    1                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          |                               2                                          |             
      Basophilic Focus                     | 1  1  1           1           1  1  1  1  1  2  2           1     1      |             
      Clear Cell Focus                     |       1                          2                 1                     |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration                         |                         2                                                |             
      Eosinophilic Focus                   |       X                                                                  |             
      Fatty Change                         |          2     3        2                                                |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Lymphoid                | 4                                                                        |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 4                 1  1        1     1  2  1  1  1  1        1  1     2   |             
      Inflammation, Granulomatous          |                            1                                             |             
      Mixed Cell Focus                     |                                        2  1     2                    2   |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               |       1                             1                             1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +                       +                           |             
      Fibrosis                             |                                              2                           |             
      Inflammation, Chronic Active         |                                              2                           |             
      Necrosis, Liquifactive               |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cytoplasmic Alteration               |    1                                                                     |             
      Ectopic Liver                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|             
                                           | 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2,000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 1  1           2  1  2           1           1  1              1  1  1   |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |    1           1                                            1            |             
      Acinus, Atrophy                      |    1           3  1                          1                 1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Sublingual Gland, Hyperplasia  |                                                                      1   |             
      Duct, Sublingual Gland, Metaplasia,  |                                                                          |             
           Squamous                        |                                     1                                    |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                  1                 1        1            |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |    1                             1  1           1           2  1         |             
      Parotid Gland, Atrophy               |       1                                                                  |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                  1                                       |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                                     1  1  1        1        2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          1              1     1                                      1   |             
      Hyperplasia, Squamous                |          2              2     2                                      1   |             
      Inflammation, Chronic Active         |                               1                                          |             
      Ulcer                                |          2              4                          2                     |             
      Muscularis, Mineralization           |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                                2         |             
      Necrosis, Coagulative                |                                                                          |             
      Mucosa, Dilatation                   | 1  1  1  1     1  1  1  1     1  1  2  1  1  2  2           1  1  2  1   |             
      Muscularis, Mineralization           |             1                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cardiomyopathy                       | 2  2  1  1     2     1  1     2  1  2  2  2  2  2  2        2  1  1  1   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|             
                                           | 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2,000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Capsule, Fibrosis                    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          | 2  2  1           1           2  2  1  1  1  2  1           1  1     1   |             
      Autolysis                            |                                                    3                     |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       1                          2  2                                    |             
      Vacuolization Cytoplasmic            |    1  1  2     1              2     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +        +  +  +  +  +  +  +        +  +  +  +   |             
      Autolysis                            |                                                    3                     |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  I     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  M  +   |             
      Pars Distalis, Angiectasis           | 2                    2           3                                       |             
      Pars Distalis, Cyst                  | 2                 1                          1              1  2         |             
      Pars Distalis, Hyperplasia           | 2              2  2           1     1        1  2                        |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      C-Cell, Hyperplasia                  | 1  1           1  1     1     1  1  1  1     1  1              1     1   |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |       1                                1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
      Hyperplasia                          |                   4     4                                   4            |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Chronic Active         | 1              2  2                 1        2  1           1  1     1   |             
      Duct, Dilatation                     |    1                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                  1     2                    2            |             
      Inflammation, Acute                  |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia             |                1                       2                             2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|             
                                           | 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2,000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Exudate                              |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Myelofibrosis               |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Fibrosis                  |       2                                                                  |             
      Bronchial, Hyperplasia, Lymphoid     |       2                                                                  |             
      Mediastinal, Hemorrhage              | 2                                            3                           |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                             2                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                         1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +     +                                                         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1     1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |             1              1                          1  1              1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Depletion Lymphoid                   |          4     4                                   2                     |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cyst                                 |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     M  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 3  3  2  2        2  2  2     2  2  3  2  3  2  2  3           2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                 X                 X      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
      Cranium, Osteopetrosis               |                                     1                                    |             
      Sternum, Osteopetrosis               |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|             
                                           | 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2,000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hydrocephalus                        |                                        1  1                          1   |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Infiltration Cellular, Histiocyte    | 1                                         1                 1            |             
      Inflammation, Chronic Active         |       3                                                                  |             
      Alveolar Epithelium, Hyperplasia     |       3                                                                  |             
      Artery, Mineralization               | 1     1  1                       1     1  1     1           1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic Active         |    1     1              1     1  1  1  1        1              1     1   |             
      Metaplasia, Squamous                 |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +  +     +  +           +                                    |             
      Cataract                             |                                     3                                    |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Neovascularization           |                                                                          |             
      Retina, Degeneration                 |                      3              3                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Hydronephrosis                       |                      4                                                   |             
      Nephropathy                          | 2  3  2  1        1  4  3     1  1  2  2  2  1  2  3        1  1  2  2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1                                                  1                     |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  M  +        +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0|                                            |            |
                                           | 4| 4| 3| 0| 8| 3| 2| 2| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      L     |
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
      Parasite Metazoan                    |                1  1                                                      |     11  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  2.5|
      Parasite Metazoan                    |                1           1                                             |      9  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  2.5|
      Parasite Metazoan                    |                      1                                                   |      8  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | 1  1  1     1     1  1                                                   |     33  1.1|
      Clear Cell Focus                     |    1                 2                                                   |      7  1.4|
      Cytoplasmic Alteration               |                1                                                         |      2  1.5|
      Degeneration                         |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         |          2              3                                                |     12  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X                 X                                                   |      6     |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |       1     1  2  1  1                                                   |     26  1.2|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |       1                                                                  |      7  1.6|
      Necrosis, Coagulative                |                2                                                         |      2  2.0|
      Pigmentation                         |                1                                                         |      1  1.0|
      Bile Duct, Hyperplasia               | 1     1  1     1  1        1                                             |     19  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fibrosis                             |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0|                                            |            |
                                           | 4| 4| 3| 0| 8| 3| 2| 2| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      L     |
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Necrosis, Liquifactive               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cytoplasmic Alteration               |                1                                                         |      2  1.0|
      Ectopic Liver                        |                                                                          |      1     |
      Inflammation, Chronic Active         |       1                 1  1                                             |     22  1.1|
      Pigmentation                         |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      6  1.5|
      Acinus, Atrophy                      |       1                    1                                             |     18  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
      Duct, Sublingual Gland, Hyperplasia  |                                                                          |      1  1.0|
      Duct, Sublingual Gland, Metaplasia,  |                                                                          |            |
           Squamous                        |       1                                                                  |      2  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |    1           1                                                         |      5  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             |    1        2     1  1     1                                             |     19  1.3|
      Parotid Gland, Atrophy               |                                                                          |      1  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |             1  1  1  1                                                   |     15  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                         2                                                |      5  1.2|
      Hyperplasia, Squamous                |                         2                                                |      6  1.7|
      Inflammation, Chronic Active         |                         2                                                |      2  1.5|
      Ulcer                                |                         3                                                |      5  2.4|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0|                                            |            |
                                           | 4| 4| 3| 0| 8| 3| 2| 2| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      L     |
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Dilatation                   | 1  1  1  1  1  2  1  1  1  1                                             |     48  1.2|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 2  1  1  1     1  2  1  1  2                                             |     48  1.4|
      Atrium, Thrombosis                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          | 1  1  1     2  1  1  1     1                                             |     36  1.3|
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                1     2                                                   |     10  1.4|
      Vacuolization Cytoplasmic            |       1                 2                                                |     14  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          |                   1     1                                                |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           |                1                                                         |      5  1.8|
      Pars Distalis, Cyst                  |       1  2     1  2                                                      |     19  1.4|
      Pars Distalis, Hyperplasia           |                2  2     1                                                |     21  1.7|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      C-Cell, Hyperplasia                  | 1  1        1  1  2  1     1                                             |     29  1.0|
      Follicular Cell, Cyst                |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0|                                            |            |
                                           | 4| 4| 3| 0| 8| 3| 2| 2| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      L     |
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Hyperplasia                          |                                                                          |      5  3.4|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Inflammation, Chronic Active         |       1  1     1  1  1  3  1                                             |     23  1.2|
      Duct, Dilatation                     |    2              2     3                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Cyst                                 | 4                                                                        |      1  4.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |          2                                                               |      1  2.0|
      Hydrometra                           | 2                                                                        |      5  1.6|
      Inflammation, Acute                  |                                                                          |      3  3.0|
      Cervix, Cyst                         |                                                                          |      2  4.0|
      Endometrium, Hyperplasia             |          1                                                               |      5  1.6|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Exudate                              |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sternal, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bronchial, Fibrosis                  |                                                                          |      1  2.0|
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                   2                                                      |      4  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +                                                            |   9        |
      Hyperplasia, Lymphoid                |             2                                                            |      2  1.5|
      Sinus, Ectasia                       |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1                                             |     57  1.0|
      Pigmentation                         |                                                                          |     10  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Depletion Lymphoid                   | 3        4                                                               |     14  3.1|
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Cyst                                 |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0|                                            |            |
                                           | 4| 4| 3| 0| 8| 3| 2| 2| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      L     |
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Galactocele                          |                                                                          |      1     |
      Hyperplasia                          | 3  2  2  3  2  3  2  2  2  4                                             |     47  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                                                                          |      2     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Hyperostosis                |                                                                          |      1  1.0|
      Cranium, Osteopetrosis               |                                                                          |      2  1.5|
      Sternum, Osteopetrosis               |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hydrocephalus                        |                                                                          |      3  1.0|
      Infarct                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Infiltration Cellular, Histiocyte    |                   1        1                                             |     10  1.0|
      Inflammation, Chronic Active         |             1        1                                                   |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
      Artery, Mineralization               |             1  1  1     1  1                                             |     19  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  M  +  +  +  +  +  +  +                                             |  56        |
      Inflammation, Chronic Active         | 2           4        1  1                                                |     23  1.3|
      Metaplasia, Squamous                 |             1                                                            |      3  2.0|
      Lumen, Foreign Body                  |             3                                                            |      1  3.0|
      Mucosa, Ulcer                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0|                                            |            |
                                           | 4| 4| 3| 0| 8| 3| 2| 2| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2,000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      L     |
     PPM FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |  10        |
      Cataract                             |                2                                                         |      2  2.5|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Cornea, Neovascularization           |                                                                          |      1  2.0|
      Retina, Degeneration                 |                3                                                         |      3  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Autolysis                            |                                                                          |      1  3.0|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Nephropathy                          | 1  2  1     2  1  2  1  4  1                                             |     49  1.7|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |                         1                                                |      1  1.0|
      Transitional Epithelium, Hyperplasia |          1     1        1                                                |      8  1.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                1                                                         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|             
                                           | 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Hyperplasia, Glandular               |                                                                          |             
      Parasite Metazoan                    |    1                                                     1     1  1  1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Parasite Metazoan                    |                               1  1                                1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Parasite Metazoan                    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       1        1  1     1     1     1        1  1     1  1     1  1      |             
      Clear Cell Focus                     |                      1                       1              1            |             
      Congestion                           |          2                                                               |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |    1                                                                     |             
      Fatty Change                         |             1                                                     3     3|             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hepatodiaphragmatic Nodule           |    X  X                    X                                             |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Chronic Active         |                1     1  1  1     1              1     1           1  1   |             
      Inflammation                         |                                                          1               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |       1                                            2                     |             
      Bile Duct, Hyperplasia               |             1  1  1     1              1  1                       1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Liquifactive               |             2                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Ectopic Liver                        |                                                                          |             
      Inflammation, Chronic Active         | 1  1     1        1           1     1           1           1  1  1  1  1|             
      Vacuolization Cytoplasmic            |                               1        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|             
                                           | 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy                      | 2  1  1  1  1     1     1     1     1           1           1     1  1  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |    1              1        1  1                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |                   1     1                                         2      |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   | 1     1                                                                  |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                   1     1     1  1           1              1     1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Acanthosis                           |                                                                         2|             
      Hyperkeratosis                       |          1  1              2                 2                           |             
      Hyperplasia, Squamous                |          1  2              3                 3                          2|             
      Inflammation, Chronic Active         |                                              2                           |             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Inflammation, Chronic Active         |                                                                         3|             
      Necrosis, Coagulative                |                                                                          |             
      Mucosa, Dilatation                   | 1  1  1     1     1  1  2  2  1  1  1     1  1  1  1        1  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  1  1  1  1  2  1     2  1  2  3  2  2  2  2        1  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          | 1  1  2  2     2  1  1  2     2  1              1        2  1  1  1  2   |             
      Degeneration                         |                   2                                                      |             
      Hyperplasia                          | 1                                                                 2      |             
      Necrosis, Coagulative                |       2                                                                  |             
      Vacuolization Cytoplasmic            |    1        2                 1  1  1        1     1           1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   2                             3                       2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|             
                                           | 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |    1  2     1              1           1     2  1  1        2  1        2|             
      Pars Distalis, Hyperplasia           | 1                 2     2              2        1                    2   |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Pigmentation        |                                                                          |             
      Rathke's Cleft, Crystals             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1        1     1  1  2        1           1     2              1  1   |             
      Follicular Cell, Cyst                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia                          |                                                                   4      |             
      Inflammation, Chronic Active         |    1              2  2     1           1  1  4  1  1        1  1  2  1   |             
      Duct, Dilatation                     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cyst                                 | 2        2                                                     2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hydrometra                           |                                                 2                 2      |             
      Inflammation, Acute                  |                   2           2                                   4      |             
      Necrosis, Coagulative                |                                                                   3      |             
      Cervix, Cyst                         |                3  2           3                                   2      |             
      Endometrium, Hyperplasia             |                   2  1                                            4  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Sternal, Autolysis                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +                 +                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |    2                                                                     |             
      Sinus, Ectasia                       |          1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2|             
      Pigmentation                         |                                                       1  1               |             
      Sinus, Ectasia                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Depletion Lymphoid                   |             3                                                           3|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Infiltration Cellular, Histiocyte    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|             
                                           | 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |       2        1                                                     4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Galactocele                          |                                              4                           |             
      Hyperplasia                          | 2  2  2  2  1  2  2  2  3  2  2  3     3  2  2  2  2        2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Sternum, Osteopetrosis               |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hydrocephalus                        |                                  1                                       |             
      Infarct                              |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1              1                 1                                       |             
      Mineralization                       |                                                       1                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                1         |             
      Artery, Mineralization               |    1           1        1  1  1  1  1     1  1  1  1           1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1  1           1              1           1  1  1      |             
      Metaplasia, Squamous                 |                                                                          |             
      Lumen, Foreign Body                  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +           +                             +                        |             
      Cataract                             |                   4                             4                        |             
      Phthisis Bulbi                       |                                                 3                        |             
      Retina, Degeneration                 |                   4                             4                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        M  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Cyst                                 |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|             
                                           | 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 2  2  2  1  2  2  1  2  2     2  2  1  2  2  4  1  1           1  2  1  1|             
      Pelvis, Inflammation, Acute          |                                     2                                    |             
      Renal Tubule, Mineralization         |          1           1  1                                         1     1|             
      Transitional Epithelium, Hyperplasia |    1                                3        1                    1      |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |    1                 1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Inflammation, Chronic Active         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|             
                                           | 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Hyperplasia, Glandular               |                                                                          |             
      Parasite Metazoan                    |                               1     1  1                    1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         2                                                |             
      Parasite Metazoan                    |                            1  2     2  1     1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         2                                                |             
      Parasite Metazoan                    |                                                             1            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Basophilic Focus                     |                1     1     1  1  1  1  1  1     1  1  1     1        1   |             
      Clear Cell Focus                     |                                  1                                       |             
      Congestion                           |                                                                          |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   | X                                                                        |             
      Fatty Change                         |                   1                                                  1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                 X        X        X                 X   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    1  1        2     1           1  1                                    |             
      Inflammation                         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |       1                                                                  |             
      Bile Duct, Hyperplasia               | 1                                                           1  1         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +                    +                                    |             
      Fibrosis                             | 4              2                                                         |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Mineralization                       | 1              1                                                         |             
      Necrosis, Liquifactive               | 3              2                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Ectopic Liver                        |                                                       X                  |             
      Inflammation, Chronic Active         |                1                 1     1        1  1        1            |             
      Vacuolization Cytoplasmic            | 1                 1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|             
                                           | 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy                      | 1              1              1  2              1           1  1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                    1                     |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |                                        1           1                     |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |       1                                                                  |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                               1     1  1                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                      1                                                   |             
      Hyperplasia, Squamous                |                      3                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                      4                                                   |             
      Necrosis, Coagulative                |                                              1                           |             
      Mucosa, Dilatation                   | 2  1  1        2  1  2  1     1  2  2  1     1  1  2  2     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Cardiomyopathy                       | 1  1           2  2  2  1     1  2  1  2     2  1  1  2        2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Angiectasis                          | 1     1        2              2  1  1  2     1  1  1  1     2     1  1   |             
      Degeneration                         |                                                                          |             
      Hyperplasia                          | 2              1              1     1           1  2           2         |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            | 1                    1                       2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                 2                       2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|             
                                           | 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  | 2  2           2                    2           1  2  1           1      |             
      Pars Distalis, Hyperplasia           | 2              1                       1     2  2  2                     |             
      Pars Intermedia, Cyst                |                                                                1         |             
      Pars Intermedia, Pigmentation        |                                                                          |             
      Rathke's Cleft, Crystals             |                                                                         4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                             1  1  1  1     2     1  1     1  1         |             
      Follicular Cell, Cyst                |                               1              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                            1                                2  1     1   |             
      Inflammation, Chronic Active         |                1              1     1  1     2  1  1        1            |             
      Duct, Dilatation                     |       1                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                               2  2              1                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Hydrometra                           |                                  2     2                                 |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia             |    1                 1                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Sternal, Autolysis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +           +                                +               |             
      Hemorrhage                           |                                                          1               |             
      Hyperplasia, Plasma Cell             |             2                                                            |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1        1  1  1  1     1  1  1  1  1  1  1  1  1   |             
      Pigmentation                         |          1  1                                            1               |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Depletion Lymphoid                   | 2                 4     4                    2     3           4         |             
      Fibrosis                             |                         1                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  M  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|             
                                           | 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  M   |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 2  3  2        2  2  3  2     2  2  2  2     3  3  2        2  2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  M   |             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Sternum, Osteopetrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Hydrocephalus                        |                                                             1            |             
      Infarct                              |                         3                                                |             
      Necrosis, Coagulative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +   |             
      Infiltration Cellular, Histiocyte    |    1           1           1  1     1  1                          1      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               | 1     1           1           1  1  1  1     1  1  1  1        1  1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic Active         | 1                    1  1           1  1     1  1  1  1        1  4  4   |             
      Metaplasia, Squamous                 |                                                                   1  2   |             
      Lumen, Foreign Body                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  I                 +  +           +               |             
      Cataract                             |                                              4                           |             
      Phthisis Bulbi                       |                                                                          |             
      Retina, Degeneration                 |                      3                       4                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Autolysis                            |                         2                                                |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|             
                                           | 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    10,000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 1  1  1        1  1  3  2     1  2  1  1     2  1  2  1     2  1  1  2   |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Mineralization         |                               1                                          |             
      Transitional Epithelium, Hyperplasia |       1                                                                  |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  M     +  +  +  +     +  +  +  +     +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5|                                            |            |
                                           | 0| 6| 6| 5| 5| 9| 9| 9| 8| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
      Hyperplasia, Glandular               |                            2                                             |      1  2.0|
      Parasite Metazoan                    |                      1  1                                                |     11  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
      Parasite Metazoan                    |             1     1  1                                                   |     11  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.0|
      Parasite Metazoan                    |                   1                                                      |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +  +                                             |  54        |
      Basophilic Focus                     | 1              1  1  1  1                                                |     30  1.0|
      Clear Cell Focus                     |    1                                                                     |      5  1.0|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration                         |                      1                                                   |      1  1.0|
      Eosinophilic Focus                   |                         X                                                |      3  1.0|
      Fatty Change                         |       3                                                                  |      6  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                X  X                                                      |     10     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1  1              1  1                                                   |     19  1.1|
      Inflammation                         |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                         2                                                |      1  2.0|
      Necrosis, Coagulative                |    1                                                                     |      4  1.3|
      Bile Duct, Hyperplasia               |                                                                          |     11  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5|                                            |            |
                                           | 0| 6| 6| 5| 5| 9| 9| 9| 8| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Liquifactive               |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +  +                                             |  50        |
      Ectopic Liver                        |                                                                          |      1     |
      Inflammation, Chronic Active         |       2        1  1  1  1                                                |     23  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.3|
      Acinus, Atrophy                      |       2           2  1  1                                                |     25  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +  +                                             |  50        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      5  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     |                      1                                                   |      1  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             |    1           1     1                                                   |      8  1.1|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic Active                   |                                                                          |      3  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |    1                                                                     |     11  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                            2                                             |      6  1.5|
      Hyperplasia, Squamous                |                            2                                             |      7  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Necrosis, Coagulative                |       2                    1                                             |      3  1.3|
      Mucosa, Dilatation                   | 2  1           1  2  1  1                                                |     45  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 2  2  1        1  2  2  2  1                                             |     47  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +                                             |  51        |
      Angiectasis                          | 1  2           1  1  1  1  1                                             |     37  1.3|
      Degeneration                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5|                                            |            |
                                           | 0| 6| 6| 5| 5| 9| 9| 9| 8| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    1              2                                                      |     11  1.5|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |    2  3        1  1                                                      |     15  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +  M  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +  +  +                                             |  52        |
      Pars Distalis, Angiectasis           |                      2                                                   |      6  2.2|
      Pars Distalis, Cyst                  |                      1     2                                             |     21  1.5|
      Pars Distalis, Hyperplasia           | 1                          2                                             |     14  1.6|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
      Pars Intermedia, Pigmentation        |                2                                                         |      1  2.0|
      Rathke's Cleft, Crystals             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  52        |
      C-Cell, Hyperplasia                  | 2              1  1  1                                                   |     24  1.2|
      Follicular Cell, Cyst                |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +        +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      5  1.8|
      Inflammation, Chronic Active         | 3  1  1           1     1                                                |     26  1.3|
      Duct, Dilatation                     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +  +  +                                             |  51        |
      Cyst                                 |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Hydrometra                           |       2           2                                                      |      6  2.0|
      Inflammation, Acute                  |                      2                                                   |      4  2.5|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Cervix, Cyst                         |                2     2                                                   |      6  2.3|
      Endometrium, Hyperplasia             |       2                                                                  |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Sternal, Autolysis                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5|                                            |            |
                                           | 0| 6| 6| 5| 5| 9| 9| 9| 8| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   6        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.0|
      Sinus, Ectasia                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +                                             |  56        |
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1  1  1  1  1                                             |     55  1.0|
      Pigmentation                         |             1                                                            |      6  1.0|
      Sinus, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +  +                                             |  51        |
      Depletion Lymphoid                   |                                                                          |      8  3.1|
      Fibrosis                             |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +        +  +  +  I  +                                             |  45        |
      Cyst                                 |                                                                          |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +  +  +  +  +                                             |  49        |
      Galactocele                          |                                                                          |      1  4.0|
      Hyperplasia                          | 2  3  3        2  2  2  2  1                                             |     47  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  51        |
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Sternum, Osteopetrosis               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Hydrocephalus                        |                                                                          |      2  1.0|
      Infarct                              |                                                                          |      1  3.0|
      Necrosis, Coagulative                |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +  +                                             |  52        |
      Infiltration Cellular, Histiocyte    | 1              1                                                         |     12  1.0|
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5|                                            |            |
                                           | 0| 6| 6| 5| 5| 9| 9| 9| 8| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    10,000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Artery, Mineralization               |    1  1           1  1  1  1                                             |     32  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Inflammation, Chronic Active         | 1  1  1                    4                                             |     23  1.4|
      Metaplasia, Squamous                 |                            2                                             |      3  1.7|
      Lumen, Foreign Body                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
      Cataract                             |                                                                          |      3  4.0|
      Phthisis Bulbi                       |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +  +                                             |  49        |
      Autolysis                            |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      1  2.0|
      Nephropathy                          | 2  2           1  2  2  2  1                                             |     47  1.6|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      6  1.0|
      Transitional Epithelium, Hyperplasia | 1                                                                        |      6  1.3|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  +  +                                             |  49        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             2                                                            |             
      Hyperplasia, Glandular               | 2  2  2  2     2  3  3  1  2  2  3  3  3     2  3  2  2  2  2  2  3  3  1|             
      Parasite Metazoan                    |                                                                1         |             
      Ulcer                                |    1              3  2  1  2  1  1        1  3  1     2     3           2|             
      Submucosa, Lamina Propria,           |                                                                          |             
          Inflammation, Chronic Active     | 2     2  2        2  2  2  2  1  2  2  2     2  2  2  2  2  3  1  2  2  2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Epithelium, Pigmentation             |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |       1                          1                                       |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                                                            |             
      Epithelium, Pigmentation             |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1        1     1  1  1  1     1  2  1        1  1  1           1  1      |             
      Clear Cell Focus                     |                   1                                         1            |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration                         |    1        2                                                            |             
      Eosinophilic Focus                   |    1                                                                     |             
      Fatty Change                         |                            1                                         2   |             
      Hepatodiaphragmatic Nodule           |                X                                X                        |             
      Inflammation, Chronic                |                                                                         1|             
      Inflammation, Chronic Active         | 1  1     2        1              1     1     1     1  1     1  1  2      |             
      Necrosis, Coagulative                |       1                                                                  |             
      Bile Duct, Hyperplasia               |                                        1        1     1           2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fibrosis                             |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Necrosis, Liquifactive               |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                1  1     1     1                 1                    1   |             
      Vacuolization Cytoplasmic            |                                                                   2      |             
      Acinus, Atrophy                      |                1  1        1  2     4  1  1     1                    1   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      | 2     1                                            1        1            |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |             1                                                            |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             | 1  1              1                 1              1        1            |             
      Parotid Gland, Atrophy               |                   2                                                      |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                   1                                                      |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  | 2  1  1           1                    1                    1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Dilatation                   | 1  2  2  2     1  1  1  1  1  1  2  2     1  1  1  2  1  1  1  1  2  1   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  1  1  1  2  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1  1     2  1  1  1  1     1  2  2  2     2  1  1  2           1      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |       1                          1     1     1                           |             
      Vacuolization Cytoplasmic            |                   1                       2     1  1              1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                              1                           |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             2                                                  3         |             
      Pars Distalis, Cyst                  |    2  2     2  2  2     1  3  2  1  1  2  3  1  1     2  1     2     1   |             
      Pars Distalis, Hyperplasia           |    2        1  2  2           1  2  3              3  2     2     2      |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                         1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                       1                  |             
      C-Cell, Hyperplasia                  | 1  1  1  2     1        1  1           1     2     2        1     2      |             
      Follicular Cell, Cyst                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                 1                          2                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2  1     1  1  1  3     1                    1  1     1     1  1  2  1   |             
      Duct, Dilatation                     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       4     2                                                            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                         3|             
      Endometrium, Hyperplasia             |                2        1                             1           2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Autolysis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                   4      |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +                                +  +                              |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |                                                                         1|             
      Sinus, Ectasia                       | 3  3  4  3  3  2  4  3  2  3  2  3  3  4  3  3  4  3  4  2  2  3  3  3  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Depletion Lymphoid                   |       2           1     1  4        3     4              3           3   |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
      Infiltration Cellular, Histiocyte    |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                1                                         1               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2  3  2  2  3  2  3  2  2  3  2  2  2  3  2  2  1  2  2  3  2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                    2                     |             
      Cranium, Osteopetrosis               |             3                                                            |             
      Sternum, Osteopetrosis               |             4                                      3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1        1        1     1     1                 1        1     1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Mineralization             |                                                                          |             
      Artery, Mineralization               | 1  1     1     1     1  1        1  1  1        1     1        1  1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1  1  1        1     1  1  1  1  1           1  1  1  1  1  2  1      |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                3                                                         |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +        +                                +   |             
      Cataract                             |                                     3                                    |             
      Phthisis Bulbi                       |                                     4                                    |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2  1  2  2  1  2  2  2     2  2  2  2  1  1  2  2  1  1  1  2  2     1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |             1                                                            |             
      Renal Tubule, Mineralization         |                      1                       1                           |             
      Transitional Epithelium, Hyperplasia |                                  1     1                       1  1  1   |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                  1     1                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|             
                                           | 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
      Hyperplasia, Glandular               | 3  3  3  3     3  1  1  2  2  2  2  2  2  2  1  2  3  1  3  3  1  1  2  2|             
      Parasite Metazoan                    |    1     1                                                               |             
      Ulcer                                |    3                          1        2  3     4  3     3  1        3  2|             
      Submucosa, Lamina Propria,           |                                                                          |             
          Inflammation, Chronic Active     | 2  3  2  2  1  1              1        2  3     3  3  2  3  2  2     2  2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Parasite Metazoan                    |                                              1                           |             
      Epithelium, Pigmentation             |             1                          1  1              1           2  1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                   1  1                                                   |             
      Epithelium, Pigmentation             |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   4      |             
      Epithelium, Pigmentation             |             1                          1  1              1           1  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     | 1  1  1  2  1     1  1        1  1  1        1     2        1  1  1  1   |             
      Clear Cell Focus                     |                1     1                                      1            |             
      Cytoplasmic Alteration               |                      2                          2                        |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                   2      |             
      Hepatodiaphragmatic Nodule           | X        X                          X        X                    X      |             
      Inflammation, Chronic                |             1                             1                          1   |             
      Inflammation, Chronic Active         | 1     1  1        1           1  1           1                 1  2      |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               |                                     1        1        1     1        1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Liquifactive               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|             
                                           | 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
      Inflammation, Chronic                |             1                          1                 1               |             
      Inflammation, Chronic Active         | 1  1     1     1  1           1              1              1  1         |             
      Vacuolization Cytoplasmic            |    1                                                                     |             
      Acinus, Atrophy                      | 2  1     1     1  1                                   1     1  1         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |    1                                                                     |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |    1     1                                            2                  |             
      Parotid Gland, Atrophy               |                                     1                                    |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                           1                              |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |    1     1                       1           1     1  1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 1                                                                        |             
      Hyperkeratosis                       |                         1                                         1      |             
      Hyperplasia, Squamous                |                         2  1                                      1      |             
      Inflammation, Chronic Active         |                         1                                                |             
      Ulcer                                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Dilatation                   | 1  2  1  1     2  2  1  1  1  1  1  1        1     1  1     1     1      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  1  2  2  2  2  1  2  3  2  1  2  1  2  2  2  1  3  2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1  2  1  1  1  1           2        1  1  2  2  1     1  2  2     1  1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                1  1  1           2  1                                    |             
      Vacuolization Cytoplasmic            |                1        2        1  1                             1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|             
                                           | 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |          1                       2                                       |             
      Necrosis, Coagulative                |                         4                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          3                                         4           3         |             
      Pars Distalis, Cyst                  | 1  1  1  1  1  1     2  2  2  2           2     3  1  2        2  1      |             
      Pars Distalis, Hyperplasia           |             2                             2  3     3  1              2   |             
      Pars Intermedia, Angiectasis         |                2                                                         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1     2        3  1  1        1  1  2        2     2        1  1         |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                             2                                    |             
      Inflammation, Chronic                |             1                          1  1                             1|             
      Inflammation, Chronic Active         |       1  1        1     3     1              2     1  2        2         |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |             3                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           | 1           2                          1     3                 1         |             
      Endometrium, Hyperplasia             |                                  2  1                                1   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Autolysis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                      2   |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                      2   |             
      Pancreatic, Pigmentation             |                                                                      1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +                    +                                    |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|             
                                           | 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1     1  1  1  1  1  1  1  2  1  1  1  1  1  2  1  1  1  1   |             
      Pigmentation                         |             1                          1  1              1           1   |             
      Sinus, Ectasia                       | 3  3  3  2  3  3  3  2  4  3  2  3  3  3  4  2  4  4  4  3  2  4     2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                         4           2                                    |             
      Fibrosis                             |                                                       3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  3  2     3  2  2  2  2  2  2  2  1  2  2  3  2  2  1  2  2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
      Cranium, Osteopetrosis               |                                                                          |             
      Sternum, Osteopetrosis               |       3  3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         3                                                |             
      Hemorrhage                           |                                        1                                 |             
      Infiltration Cellular, Histiocyte    |    1     1                 1     1     1     1     1  1  1  1     1      |             
      Alveolar Epithelium, Hyperplasia     |    3                                1  1                                 |             
      Alveolus, Mineralization             |                                                                          |             
      Artery, Mineralization               |    1  1  1                 1     1           1  1  1  1     1     1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1  1  1     1  1  1  1     1  1  4        1  1     1           1      |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                         3|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                   2                                                      |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|             
                                           | 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    50,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Acute                           |                                        1                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +        +     +           +           +     +|             
      Cataract                             |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Lens, Cataract                       |                                           2                              |             
      Retina, Degeneration                 |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                2         |             
      Nephropathy                          | 2  2  1  2  1  3  2  2        2  3  1  1  1  2  2  2  2  2  2  2  2  1  2|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                                          |             
      Renal Tubule, Mineralization         |                   1                 1  1  1     1                 1     1|             
      Transitional Epithelium, Hyperplasia |                               1              1        1                  |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 3| 3| 7| 6| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5|                                            |            |
                                           | 8| 8| 2| 9| 1| 7| 1| 3| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |             4                                                            |      3  3.0|
      Hyperplasia, Glandular               | 1  2  2  3     3  3  1  3  3                                             |     56  2.2|
      Parasite Metazoan                    |                1                                                         |      4  1.0|
      Ulcer                                |          3     3     3                                                   |     26  2.2|
      Submucosa, Lamina Propria,           |                                                                          |            |
          Inflammation, Chronic Active     |          4  2  4  2  2  3  2                                             |     45  2.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Edema                                |                      1                                                   |      1  1.0|
      Hyperplasia, Glandular               |                2                                                         |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1  1.0|
      Epithelium, Pigmentation             |                            1                                             |      8  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |             4                                                            |      1  4.0|
      Edema                                |                      2                                                   |      1  2.0|
      Parasite Metazoan                    |                                                                          |      4  1.0|
      Epithelium, Pigmentation             |                            1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |             4                                                            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |             4                                                            |      3  3.7|
      Epithelium, Pigmentation             |                         1  1                                             |      9  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |             4                                                            |      3  3.7|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |    1                 2                                                   |      3  1.7|
      Basophilic Focus                     | 1              1  1  2  1                                                |     35  1.1|
      Clear Cell Focus                     |          1                                                               |      6  1.0|
      Cytoplasmic Alteration               |                                                                          |      2  2.0|
      Degeneration                         |                                                                          |      2  1.5|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Fatty Change                         |                      2                                                   |      4  1.8|
      Hepatodiaphragmatic Nodule           |    X              X                                                      |      9     |
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Inflammation, Chronic Active         |             1  1  2  1  1                                                |     26  1.2|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 3| 3| 7| 6| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5|                                            |            |
                                           | 8| 8| 2| 9| 1| 7| 1| 3| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Bile Duct, Hyperplasia               |       1  1        1                                                      |     14  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                      2                                                   |      2  2.0|
      Necrosis, Liquifactive               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Chronic Active         | 1  1                                                                     |     17  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.5|
      Acinus, Atrophy                      |       2                                                                  |     18  1.3|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      | 1                                                                        |      6  1.2|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             | 1                                                                        |     10  1.1|
      Parotid Gland, Atrophy               |                                                                          |      2  1.5|
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |     12  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      1  1.0|
      Hyperkeratosis                       |                      2                                                   |      3  1.3|
      Hyperplasia, Squamous                |                      2                                                   |      4  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Dilatation                   |    2  1  1        1  1                                                   |     44  1.3|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 3| 3| 7| 6| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5|                                            |            |
                                           | 8| 8| 2| 9| 1| 7| 1| 3| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 2  2  2     2  2  2  1  2  1                                             |     58  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Angiectasis                          | 1  2           1                                                         |     38  1.4|
      Hemorrhage                           |             2                                                            |      1  2.0|
      Hyperplasia                          |                                                                          |      9  1.1|
      Vacuolization Cytoplasmic            |          1                                                               |     11  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Hyperplasia                          |                                                                          |      3  1.3|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      5  3.0|
      Pars Distalis, Cyst                  |    2  3     1  2     3  2  1                                             |     41  1.7|
      Pars Distalis, Hyperplasia           |    2  2                                                                  |     19  2.1|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  | 1              1  1  1  1                                                |     29  1.3|
      Follicular Cell, Cyst                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   2        |
      Necrosis                             |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +                                             |  58        |
      Hyperplasia                          | 4     2                                                                  |      7  2.3|
      Inflammation, Chronic                |                         1  1                                             |      6  1.0|
      Inflammation, Chronic Active         | 2  1           1                                                         |     26  1.4|
      Duct, Dilatation                     |    2           2                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 3| 3| 7| 6| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5|                                            |            |
                                           | 8| 8| 2| 9| 1| 7| 1| 3| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrometra                           |                         2                                                |      7  1.9|
      Endometrium, Hyperplasia             | 1  1                                                                     |      9  1.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sternal, Autolysis                   |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      2  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +                                                               |   7        |
      Sinus, Ectasia                       |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Histiocyte    | 1  1     1     1  1  1  1  1                                             |     55  1.0|
      Pigmentation                         |                         1  1                                             |      8  1.0|
      Sinus, Ectasia                       | 3  3  2  2  2  2  2  4  2  2                                             |     59  2.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  2.0|
      Depletion Lymphoid                   |    2                                                                     |     11  2.6|
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  I  M  M  +  +  +  M  +  +                                             |  50        |
      Cyst                                 |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M                                             |  59        |
      Hyperplasia                          | 2  2  2  1  1  3  3  2                                                   |     54  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  I  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Hyperostosis                |                                                                          |      1  2.0|
      Cranium, Osteopetrosis               |                                                                          |      1  3.0|
      Sternum, Osteopetrosis               |                                                                          |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 3| 3| 7| 6| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5|                                            |            |
                                           | 8| 8| 2| 9| 1| 7| 1| 3| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1                                                                        |     20  1.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      4  1.8|
      Alveolus, Mineralization             |                         1                                                |      1  1.0|
      Artery, Mineralization               | 1  1  1     1  1        1                                                |     32  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 1        4     1                                                         |     35  1.2|
      Metaplasia, Squamous                 |          2                                                               |      1  2.0|
      Mucosa, Submucosa, Inflammation,     |                                                                          |            |
           Chronic Active                  |                         1                                                |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      2  2.5|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +  +        +                                                      |  13        |
      Cataract                             | 4                                                                        |      2  3.5|
      Phthisis Bulbi                       |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Degeneration                 | 4                                                                        |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |             2                                                            |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Nephropathy                          | 2  2  2  2     2  2  1  1  1                                             |     55  1.7|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |                                                                          |      1  1.0|
      Renal Tubule, Mineralization         | 1     1  1              1  1                                             |     14  1.0|
      Transitional Epithelium, Hyperplasia | 1                 1                                                      |     10  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 3| 3| 7| 6| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5|                                            |            |
                                           | 8| 8| 2| 9| 1| 7| 1| 3| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    50,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    PPM FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|             
                                           | 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         3|             
      Parasite Metazoan                    |             1           1  1                                         1   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         3|             
      Parasite Metazoan                    |                1  3  3  1           2                       2            |             
      Polyarteritis                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         2|             
      Parasite Metazoan                    | 1        1        1     1  1        2           1                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         4|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    4                    2                                               4|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                             1                                          |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     |                X  1                                         X            |             
      Clear Cell Focus                     |                   X           1     X                                    |             
      Degeneration                         |       1                                                                  |             
      Eosinophilic Focus                   | X                                   X                                    |             
      Fatty Change                         |                                        2  1     2                 3      |             
      Hepatodiaphragmatic Nodule           | X  X                    X                                                |             
      Hyperplasia                          |                3                                                         |             
      Inflammation, Chronic Active         |          1  1     1     1           1              2                 1   |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation                         |                                                          1               |             
      Bile Duct, Hyperplasia               | 1  2  2  1     2  1  1  2     1     1  2  2  1  2  1  1  1  2  1     1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                             +              +            |             
      Fibrosis                             |                1                                            3            |             
      Hemorrhage                           |                2                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Liquifactive               |                                                                          |             
      Artery, Inflammation, Chronic        |                                              1              2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|             
                                           | 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic                |             1                                                            |             
      Inflammation, Chronic Active         |                      1           1                 1              1      |             
      Vacuolization Cytoplasmic            |                2                 1        1  1  2                        |             
      Acinus, Atrophy                      |       1           1           1        1              2     2     1      |             
      Acinus, Hyperplasia                  |                1  2                                            2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                   2  1           1                                       |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                1         |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |             1     2  1              2              1     2               |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   | 1                    1                          1                        |             
      Submandibular Gland, Atrophy         |                                                                2         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |          1  1              1                                             |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                   2  1           2  1        1  1              2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Hyperkeratosis                       |                                                                   2      |             
      Hyperplasia, Squamous                |                                                    1              3      |             
      Inflammation, Chronic Active         |    1                                      1                       4      |             
      Ulcer                                |                                                                   4      |             
      Muscularis, Mineralization           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         2|             
      Fibrosis                             |                                              1                           |             
      Inflammation, Chronic Active         |                1                             1  1                 2      |             
      Metaplasia, Squamous                 |                                  2                                       |             
      Ulcer, Acute                         |                                           2                              |             
      Mucosa, Dilatation                   | 1  1  1        1  1  1  1     1     1  1  1  1  1  1  1     1  1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           2                              |             
      Autolysis                            |                                                                          |             
      Cardiomyopathy                       | 2  2  2  2  2  3  2  2  2  2  2  2  2  3  2  3  2  2  2  1  2  2  2  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|             
                                           | 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |    1                                                                     |             
      Atrium, Thrombosis                   |                                           3     2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     2                       2     1                                    |             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                     1              2                     |             
      Vacuolization Cytoplasmic            |    1     1     2              1  2  1  1  1              1        2     1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                2                    1  1        1  3        2  2         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Autolysis             |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 1     1        1     1              1        1  1        1               |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                   1                                                      |             
      Pigmentation                         |                   1                                         1            |             
      C-Cell, Hyperplasia                  | 1                 1                                2        1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                  +  +  +     +  +                        |             
      Atrophy                              |                                                 4                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |    1                             1                                       |             
                                            __________________________________________________________________________|             
   Penis                                   |                                           +                              |             
      Inflammation, Acute                  |                                           1                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|             
                                           | 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Chronic Active         |       1  2     1  2  2  1     2     2  1  2  2  1  1  1  1     1  1  2  1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |             1                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    2     2     1        4           1  3  3  2  1  1  1  2  1     2     1|             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                 2  2        2  2  3  2     2  2     3  2  2  3  2      |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                           2        1                     |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  1  1  1  1  1  1     1     1     1  1  1           1  1     1  1      |             
      Seminiferous Tubule, Atrophy         | 4           2     4  4        4  4  4  4  1  4  4  4        4  4         |             
      Seminiferous Tubule, Mineralization  | 1              1     1        1     1  4  1     1           1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |    4                                                                     |             
      Sternal, Autolysis                   |                                                                          |             
      Sternal, Hypocellularity             |                                                                          |             
      Sternal, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                            1                    1                        |             
      Pancreatic, Pigmentation             |                            1                                             |             
      Pancreatic, Sinus, Ectasia           |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +        +        +     +  +  +  +  +     +        +     +         |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Hyperplasia, Plasma Cell             |                                                          3     2         |             
      Infiltration Cellular, Histiocyte    |                         1                                                |             
      Sinus, Ectasia                       | 1                             1  1  1                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |          1  1              1                                         1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |    3  2        3                       3        3     3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|             
                                           | 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                  2        2  1                           |             
      Hyperplasia, Lymphoid                |                                                                1         |             
      Infiltration Cellular, Histiocyte    |                                                    2                     |             
      Necrosis, Coagulative                |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  I  +  +  +  M  +  M  +  +  +  M  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  M|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 1  1  1  1  1  2  1  2  2  2  2  2  1  2  2  1  2  1           1     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lip, Inflammation, Acute, Necrotizing|                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           1                              |             
      Autolysis                            |                                                                          |             
      Cerebellum, Infarct                  |       3                                                                  |             
      Cerebrum, Infarct                    |                                                                          |             
      Pons, Infarct                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                2         |             
      Infiltration Cellular, Histiocyte    | 1                                      1              1     1            |             
      Inflammation, Chronic Active         |                                  2                             2         |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
      Artery, Mineralization               |                   1        1     1                 1     1     1  1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 4  2  2        2        4     2  4        2  3  1  1     2  1  3         |             
      Metaplasia, Squamous                 | 2     2                 3  2     2           2           2           2   |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Inflammation, Acute           |             2              2                                         2   |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|             
                                           | 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                            2                                         2   |             
      Mucosa, Submucosa, Lumen,            |                                                                          |             
          Inflammation, Chronic Active     |          2                                                               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +                                +  +        +                        |             
      Cataract                             |                                                 3                        |             
      Phthisis Bulbi                       |                                                                          |             
      Anterior Chamber, Hemorrhage         |                                                 4                        |             
      Retina, Degeneration                 |                                                 4                        |             
      Sclera, Metaplasia, Osseous          |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           3                              |             
      Autolysis                            |                                                                         2|             
      Congestion                           |          1                                                               |             
      Cyst                                 |                                              2                 2         |             
      Glomerulosclerosis                   |    4                                                                     |             
      Nephropathy                          | 3  4  1  2  2  3  3  3  2  2  2  3  3  2  2  3     2  2  1  2  3  3  2  2|             
      Artery, Mineralization               |    1                                                                     |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             | 1  1           1                       1                                 |             
      Renal Tubule, Inflammation, Acute    |                                                                          |             
      Renal Tubule, Mineralization         |    2                                                                     |             
      Transitional Epithelium, Hyperplasia |    2           1  1  1           1  1        1                 2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         2|             
      Calculus Micro Observation Only      |                         3                                                |             
      Inflammation, Chronic Active         | 1                             1                                          |             
      Polyarteritis                        |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|             
                                           | 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Ulcer                                |                         1                                                |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     2        4                           |             
      Parasite Metazoan                    | 1     1     1  1  1              1        1                 1           1|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     1        4                           |             
      Parasite Metazoan                    |                1                                            1  2        1|             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Parasite Metazoan                    |                                  1              1                    2  1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     2        4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                          2        4                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3        4                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  1  1           1                        |             
      Autolysis                            |                                              2                           |             
      Basophilic Focus                     |       X                          X  X           X  X                     |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration                         |                            2     1           1                           |             
      Eosinophilic Focus                   |                                  X                                       |             
      Fatty Change                         |                      2                 1           2                     |             
      Hepatodiaphragmatic Nodule           |                   X           X                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |       1                 1              1  1        1                 1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation                         |       1                                                                  |             
      Bile Duct, Hyperplasia               | 1  2  1  1     2  1  1  1  1  1  1  1  1  1  2  2  1  1     1  1     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +     +     +                          +                  |             
      Fibrosis                             |       3        1           3                          2                  |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |       2                    3                          2                  |             
      Necrosis, Liquifactive               |       2        2           2                          2                  |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|             
                                           | 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                             1                              |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic                |                                           1              1              1|             
      Inflammation, Chronic Active         | 1  1  1           1     1              1        1  1              1  1   |             
      Vacuolization Cytoplasmic            |    1                          2     2                          2         |             
      Acinus, Atrophy                      | 2  1  1                 1           1  2        1  1           1  1  1   |             
      Acinus, Hyperplasia                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |       1                       1  1                                       |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                  1                                       |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |       1                          1  1                                    |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Submandibular Gland, Atrophy         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |             1                             1              1               |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |    1                       1  1  1  1                       1        1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Autolysis                            |                                              4                           |             
      Hyperkeratosis                       |                                        2                                 |             
      Hyperplasia, Squamous                |    1                                   2              4                  |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Ulcer                                |                                                       2                  |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Ulcer, Acute                         |                                                                          |             
      Mucosa, Dilatation                   | 2  1  1  1     1  1     1        1     1        1  1  1     2  1  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Autolysis                            |                                              2                           |             
      Cardiomyopathy                       | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  3  1  2     2  1  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|             
                                           | 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               1        1                    1            |             
      Autolysis                            |                                              4                           |             
      Hyperplasia                          |                                                    2        2        1  1|             
      Vacuolization Cytoplasmic            | 1     1           2  1           1  1              2        1  1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Hyperplasia                          |       1        2     1                          1     1                  |             
      Inflammation, Chronic Active         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                                           1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Autolysis             |                                              3                           |             
      Pars Distalis, Cyst                  |                         2                                      2     1   |             
      Pars Distalis, Hyperplasia           |    2     2              1     3        1  2     1              1  1  1  1|             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |          1                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         | 1                                                                        |             
      C-Cell, Hyperplasia                  | 1  2              2                             2  1           1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |    +                             +              +                        |             
      Atrophy                              |    2                             2              2                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Inflammation, Chronic Active         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              2                           |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|             
                                           | 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |             1                                                           1|             
      Inflammation, Chronic Active         | 1  2  1        2  2  1  1     4  2  1  1  1     1  3        1  1  1  1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              2                           |             
      Dilatation                           |                                                 2                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                          1               |             
      Inflammation, Chronic Active         | 2  3  3  2     2  3  1  1           1  1     2  1  4  4        1        2|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  2  2  2     2     2  2     2  2              3           2  2         |             
      Autolysis                            |                                              2                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Hemorrhage                           |                                                                   1      |             
      Interstitial Cell, Hyperplasia       |       1     1  1        1  1  1     2  1  2           1  1     1  1  1  1|             
      Seminiferous Tubule, Atrophy         | 4  4  1  2     2        3     4  4  2           4           4  4         |             
      Seminiferous Tubule, Mineralization  | 1        1     1        1     1  1  1           1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                                          |             
      Sternal, Autolysis                   |                                              4                           |             
      Sternal, Hypocellularity             |                                                                          |             
      Sternal, Myelofibrosis               |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Hemorrhage               |                                           1                              |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                           1                             1|             
      Pancreatic, Pigmentation             |                                           1                             1|             
      Pancreatic, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +        +     +  +              +     +  +  +      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                     2                       3            |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Sinus, Ectasia                       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  2  1  1  1  2     1  1  1  1  1  1  2     1  1     1  1  1     1  1|             
      Pigmentation                         |             1                             1              1              1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Depletion Lymphoid                   |    2           3     3                       3        4        2  4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|             
                                           | 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                      2                             1  2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis, Coagulative                |                      2                                                   |             
      Capsule, Inflammation, Chronic       |       1                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                  2                                       |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  M  +  +  +  M  +  +  M  +  +|             
      Galactocele                          |       3                                                                  |             
      Hyperplasia                          | 3  1  3  1  2     3     2  2  2           1     2  3  2     1        1  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lip, Inflammation, Acute, Necrotizing|                      3                                                   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Autolysis                            |                                              2                           |             
      Cerebellum, Infarct                  |                                                       2                  |             
      Cerebrum, Infarct                    |                                                       2                  |             
      Pons, Infarct                        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              2                           |             
      Congestion                           |                                           2                              |             
      Foreign Body                         |                         2                                                |             
      Infiltration Cellular, Histiocyte    |       1                          1     1                                1|             
      Inflammation, Chronic Active         |                         4                                   2            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               | 1        1  1     1        1  1        1  1  1  1  1     1     1     1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1  3              4  1  3  1  1  1        2  1  2     4  1  1      |             
      Metaplasia, Squamous                 |          1                    2                       1                  |             
      Lumen, Foreign Body                  |                         2                                   2            |             
      Lumen, Inflammation, Acute           |                                                                          |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|             
                                           | 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                                                          |             
      Mucosa, Submucosa, Lumen,            |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                 +     +        +  +              +                  |             
      Cataract                             |    4                                                                     |             
      Phthisis Bulbi                       |    3                                                                     |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Retina, Degeneration                 |    4                                                                     |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Autolysis                            |                                              4                           |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                1         |             
      Glomerulosclerosis                   |                                                                          |             
      Nephropathy                          | 2  4  2  2  2  2  3  2  3  2  3  4  3  3  1     3  2  2  2  3  3  2  2  2|             
      Artery, Mineralization               |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                  1                             1         |             
      Renal Tubule, Inflammation, Acute    |             1                                                            |             
      Renal Tubule, Mineralization         |                                                                          |             
      Transitional Epithelium, Hyperplasia | 2  1                             2                             1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Calculus Micro Observation Only      |    2                                                                     |             
      Inflammation, Chronic Active         |                               1                                          |             
      Polyarteritis                        |                   2                                                      |             
      Artery, Necrosis, Fibrinoid          |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      3  3.0|
      Parasite Metazoan                    | 1  1        1              1                                             |     17  1.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      3  2.7|
      Parasite Metazoan                    |    2           1  1                                                      |     13  1.6|
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  3.0|
      Parasite Metazoan                    |    1                 1     1                                             |     14  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |             4                                                            |      4  3.3|
      Hyperplasia, Lymphoid                |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      5  1.0|
      Autolysis                            |                                                                          |      1  2.0|
      Basophilic Focus                     |                            X                                             |      9  1.0|
      Clear Cell Focus                     |                                                                          |      3  1.0|
      Degeneration                         |    1  1        1                                                         |      7  1.1|
      Eosinophilic Focus                   |       X                                                                  |      4     |
      Fatty Change                         |       1  2                                                               |      9  1.8|
      Hepatodiaphragmatic Nodule           |             X  X                                                         |      7     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1                          1                                             |     16  1.1|
      Mixed Cell Focus                     |                      X                                                   |      1     |
      Pigmentation                         |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               | 1  3  1  1  1  1  1  1  1  1                                             |     52  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |          2                                                               |      7  2.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.3|
      Necrosis, Liquifactive               |          3                                                               |      5  2.2|
      Artery, Inflammation, Chronic        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                            2                                             |      3  1.3|
      Cytoplasmic Alteration               |       1        1                                                         |      2  1.0|
      Inflammation, Chronic                |                            1                                             |      5  1.0|
      Inflammation, Chronic Active         | 1                 1                                                      |     16  1.0|
      Vacuolization Cytoplasmic            |    2                                                                     |     10  1.6|
      Acinus, Atrophy                      | 1  1  1           1                                                      |     22  1.2|
      Acinus, Hyperplasia                  |             3                                                            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      | 1                                                                        |      7  1.1|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     | 1                                                                        |      3  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             | 1                    1                                                   |     11  1.3|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic Active                   |                1                                                         |      4  1.0|
      Submandibular Gland, Atrophy         |                                                                          |      1  2.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      6  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  | 1  1        1     1                                                      |     18  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |       1                                                                  |      1  1.0|
      Autolysis                            |                                                                          |      1  4.0|
      Hyperkeratosis                       | 2     1                                                                  |      4  1.8|
      Hyperplasia, Squamous                | 3     1                                                                  |      7  2.1|
      Inflammation, Chronic Active         |                                                                          |      4  2.0|
      Ulcer                                |                                                                          |      2  3.0|
      Muscularis, Mineralization           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
      Fibrosis                             |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      4  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Ulcer, Acute                         |                                                                          |      1  2.0|
      Mucosa, Dilatation                   | 1  2     1  1  1  2  1  1                                                |     40  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  2.0|
      Autolysis                            |                                                                          |      1  2.0|
      Cardiomyopathy                       | 2  2  1  2  2  2  2  2  2  2                                             |     58  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                      1                                                   |      8  1.3|
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia                          |                2     1                                                   |      8  1.5|
      Vacuolization Cytoplasmic            |       2  2                                                               |     22  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia                          |       1                                                                  |     13  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Autolysis             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                3                                                         |      4  2.0|
      Pars Distalis, Hyperplasia           | 2     1     1  2        2  2                                             |     25  1.4|
      Pars Intermedia, Angiectasis         |          3                                                               |      1  3.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      3  1.0|
      C-Cell, Hyperplasia                  | 1           2     3  1                                                   |     18  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |    +           +                                                         |  10        |
      Atrophy                              |                3                                                         |      5  2.6|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Chronic Active         | 1  2  2  4  1  1  2  2  2                                                |     46  1.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1  4  3  1  2     3  4  2                                                |     39  2.1|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 2     2  2     2  2  2  2                                                |     33  2.1|
      Autolysis                            |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |    1     1     1  1     1  1                                             |     37  1.1|
      Seminiferous Tubule, Atrophy         | 4     2     2  4  3  4  4                                                |     33  3.4|
      Seminiferous Tubule, Mineralization  | 1           1     1  1  1                                                |     22  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Calvarium, Myelofibrosis             |                                                                          |      1  4.0|
      Sternal, Autolysis                   |                                                                          |      1  4.0|
      Sternal, Hypocellularity             |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sternal, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pancreatic, Hemorrhage               |                            1                                             |      2  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                            1                                             |      5  1.0|
      Pancreatic, Pigmentation             |                            1                                             |      4  1.0|
      Pancreatic, Sinus, Ectasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +                                                      |  22        |
      Hyperplasia, Lymphoid                |                1                                                         |      2  1.5|
      Hyperplasia, Plasma Cell             |                                                                          |      4  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
      Sinus, Ectasia                       |                   2                                                      |      6  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1                                             |     56  1.1|
      Pigmentation                         |                            1                                             |      9  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Depletion Lymphoid                   |    2  2  3     2  2     3                                                |     19  2.7|
      Fibrosis                             |             1        2                                                   |      8  1.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  +                                             |  47        |
      Galactocele                          |    4                 3                                                   |      3  3.3|
      Hyperplasia                          | 1  2  3  2        3  4     1                                             |     43  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lip, Inflammation, Acute, Necrotizing|                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  1.0|
      Autolysis                            |                                                                          |      1  2.0|
      Cerebellum, Infarct                  |                                                                          |      2  2.5|
      Cerebrum, Infarct                    |                                                                          |      1  2.0|
      Pons, Infarct                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |                   1                                                      |      9  1.0|
      Inflammation, Chronic Active         | 2                                                                        |      5  2.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Artery, Mineralization               |    1  1  1        1        1                                             |     27  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 1  1  2  1  4  1  2  1                                                   |     36  2.0|
      Metaplasia, Squamous                 |       2           1                                                      |     13  1.8|
      Lumen, Foreign Body                  |                   1                                                      |      3  1.7|
      Lumen, Inflammation, Acute           |                                                                          |      3  2.0|
      Mucosa, Submucosa, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      2  2.0|
      Mucosa, Submucosa, Lumen,            |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                      3                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +  +           +                                                |  15        |
      Cataract                             |                                                                          |      2  3.5|
      Phthisis Bulbi                       |                                                                          |      1  3.0|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      2  4.0|
      Sclera, Metaplasia, Osseous          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 7| 7| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5|                                            |            |
                                           | 2| 5| 7| 4| 3| 5| 5| 5| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Autolysis                            |                                                                          |      2  3.0|
      Congestion                           |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      3  1.7|
      Glomerulosclerosis                   |                                                                          |      1  4.0|
      Nephropathy                          | 2  4  3  3  3  2  3  3  4  2                                             |     58  2.5|
      Artery, Mineralization               |                                                                          |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |       1        1     1  1                                                |     10  1.0|
      Renal Tubule, Inflammation, Acute    |                                                                          |      1  1.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |    2  2  1     2  1  1  1                                                |     19  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  2.5|
      Calculus Micro Observation Only      |    2                                                                     |      4  2.3|
      Inflammation, Chronic Active         |                                                                          |      3  1.0|
      Polyarteritis                        |                                                                          |      1  2.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|             
                                           | 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +           +  +  +  M  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Parasite Metazoan                    |       1              2     1     1                       1               |             
      Epithelium, Pigmentation             |                                                                      1   |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |    1  1                 2           1                    1  1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                 1           2            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                | 2                                                  2     2  2            |             
      Epithelium, Pigmentation             |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                                4         |             
      Muscularis, Hyperplasia              |                                                                3         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                              1                           |             
      Basophilic Focus                     |    X              X           X                                          |             
      Clear Cell Focus                     |          1                             1        1                        |             
      Degeneration                         |                                  1        1           1                  |             
      Eosinophilic Focus                   |          X                       X           X                           |             
      Fatty Change                         |                      1              1                                    |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 1                    1  1                       2  2                 1   |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation                         |                                                    2                     |             
      Bile Duct, Hyperplasia               |    1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  2  1  1     1  1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|             
                                           | 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                              1                           |             
      Inflammation, Chronic Active         | 1     1  1  2  1  2           1                 1              1         |             
      Polyarteritis                        |       3                                         2                        |             
      Vacuolization Cytoplasmic            |                   2              1        1                              |             
      Acinus, Atrophy                      | 2     1           2           1     1           1     1     2  2  1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                        1        1  3                     |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |    1     2     2                                         2     1         |             
      Submandibular Gland, Fibrosis        |                                                    2                     |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |    1     1     1                             1     2     1               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                               1     1                                    |             
      Hyperplasia, Squamous                |                               4     2                                    |             
      Ulcer                                |                               4     3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Necrosis, Coagulative                |                                                       2                  |             
      Epithelium, Pigmentation             |                            1                                             |             
      Mucosa, Dilatation                   | 2  1  1  1  1  1  2           1  1  1  1     1  1  1  1  1  2  2  1      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy                       | 2  2  2  2  2  2  2           2  2  2  2  2  2  2  2  3  2  2  2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Angiectasis                          | 1           1  2                                   1     2     2         |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hyperplasia                          | 1                                                                        |             
      Vacuolization Cytoplasmic            | 1                                2  2     1     1                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                2              1  2                          2            |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|             
                                           | 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +           +  +  +  M  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          | 2           2                 3                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Autolysis             |                                                                          |             
      Pars Distalis, Cyst                  | 1                                                  2                     |             
      Pars Distalis, Hyperplasia           | 2           1                       1  2     2  2     1                  |             
      Pars Intermedia, Angiectasis         |                                                             2            |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pigmentation                         |                                                    1                     |             
      C-Cell, Hyperplasia                  |                1  2              1        2        1     4     1         |             
      Follicular Cell, Cyst                |                                              1                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic Active         |                                  1                             1         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |                      1                                                   |             
      Inflammation, Chronic Active         | 1  1  1  2  2  1              1  1  1  2  1  2  2  1  1  2  2  1  3      |             
      Duct, Dilatation                     |                   2                                   4           3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic Active         | 1  1                          3           1  1  4  1     1  2     1      |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Atrophy                              | 3  3  3  3  3  3  2                 3     4  3  3  3  3     4  4         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Polyarteritis                        |                                  4                                       |             
      Interstitial Cell, Hyperplasia       |    1        1     1     1     1     1  1  1     1  1     1  1  1  1  1   |             
      Seminiferous Tubule, Atrophy         | 4  4  4  4  4  4  4              3  4     3  4  3  4  4  4  4  4  1      |             
      Seminiferous Tubule, Mineralization  | 1        1  1  1  1                 1        1        1  1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Sternal, Autolysis                   |                                                                          |             
      Sternal, Myelofibrosis               |                                                             1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|             
                                           | 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                 2                        |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +           +                          +           +         |             
      Hemorrhage                           |                         2                                                |             
      Hyperplasia, Lymphoid                |    2                                               1           1         |             
      Hyperplasia, Plasma Cell             | 2  2                                                                     |             
      Sinus, Ectasia                       |             3                                      2           2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            2     2                                       |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1     1  1|             
      Pigmentation                         |                      1  1  1                                         1  1|             
      Sinus, Ectasia                       |                                                       1                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                           4                 1            |             
      Fibrosis                             |                   3           2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  M      |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +           +  +  M  M  +  +  +  +  +  +  +  +  +      |             
      Galactocele                          |                                  2                                       |             
      Hyperplasia                          | 1  2  1  1     2  2           2  3        1  1  2  2  1  1  2     2      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Acanthosis                           |                                                          2               |             
      Hyperkeratosis                       |                                                          4               |             
      Hyperplasia, Basal Cell              |                                                          2               |             
      Inflammation, Acute, Necrotizing     |                      4                                                   |             
      Foot, Acanthosis                     |                                  1                                       |             
      Foot, Hyperkeratosis                 |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cranium, Hyperostosis                |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Gliosis                              |                                                       1                  |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|             
                                           | 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                1         |             
      Infiltration Cellular, Histiocyte    | 1  1           1        1     1  1  2                 1                  |             
      Inflammation, Chronic Active         |                                        4                       2         |             
      Artery, Mineralization               | 1        1  1     1  1        1     1     1     1  1  1              1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic Active         | 1     4  1  1  4  3           1           1  1  1  1        3  4  1      |             
      Metaplasia, Squamous                 |       2        3  2                                         2            |             
      Lumen, Foreign Body                  |                                                                2         |             
      Mucosa, Ulcer                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                       +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                2                                                         |             
      Nephropathy                          | 4  3  3  3  4  3  3           4  4  2  2  1  3  3  2  2  3  3  3  2      |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                1                                   1     1               |             
      Transitional Epithelium, Hyperplasia |       1  1  2  1  1           1  1           1  1     1     2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Autolysis                            |                                                                          |             
      Polyarteritis                        |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|             
                                           | 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2,000                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Hyperplasia, Glandular               |                4                                                         |             
      Parasite Metazoan                    |             1     1                                            1        1|             
      Epithelium, Pigmentation             |                                                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Parasite Metazoan                    |                1                          1  1     1                 1  1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Parasite Metazoan                    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            4           4                                 |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Inflammation, Chronic                |                                                                          |             
      Muscularis, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Basophilic Focus                     |    X                                                                     |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration                         |       1                                      1                           |             
      Eosinophilic Focus                   |          X     2                                                         |             
      Fatty Change                         |                   1     2     1           1                       2  1   |             
      Hepatodiaphragmatic Nodule           |    X                                         X           X        X      |             
      Hyperplasia                          |       3                 3        3                 4                     |             
      Inflammation, Chronic Active         |                1              1           1              1  1           1|             
      Mixed Cell Focus                     |    X                                                                     |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  1     1  1  2  1  2  1  1  2  2        1  1  3  1     1  2  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                  +                  |             
      Fibrosis                             |    2                                                                     |             
      Inflammation, Chronic Active         |    4                                                                     |             
      Necrosis, Liquifactive               |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|             
                                           | 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2,000                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                        3                                 |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic Active         |    1     1           1     1  1                 1              1         |             
      Polyarteritis                        |                                                                          |             
      Vacuolization Cytoplasmic            |                      1  2        2                                       |             
      Acinus, Atrophy                      |    2              3     1        1              1  1  1        2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                3  2              1                 1              2      |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                1         |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |    1           2              1  1                 1        2  1         |             
      Submandibular Gland, Fibrosis        |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |    1        1     1                                         1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       | 1                    1                          1                        |             
      Hyperplasia, Squamous                | 1                    2                          2                        |             
      Ulcer                                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Fibrosis                             |                      2                                                   |             
      Necrosis, Coagulative                |                      1                                   1               |             
      Epithelium, Pigmentation             |                                                                          |             
      Mucosa, Dilatation                   |    1  1  1  1  1  2  1  1  1  1  1  2        1  1  1  1     1  1  1  1   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
      Hemorrhage                           |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 2  2  2  2  2  2  2  3  1  3  2  2  1  1     2  2  1  1  1  3  2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                      1        2                                          |             
      Vacuolization Cytoplasmic            |             1  1     2  2     1  1           1           1  1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                 2  1  1                  |             
      Inflammation, Chronic Active         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|             
                                           | 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2,000                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis, Coagulative                |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                            1                    1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  I  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                   2                             2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Autolysis             |                                        3                                 |             
      Pars Distalis, Cyst                  |                                                    1                     |             
      Pars Distalis, Hyperplasia           |    1  2     2  2        1     2                 2        1  1            |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Pigmentation                         |                                                                      1   |             
      C-Cell, Hyperplasia                  |                1  1  1  1        1           2  1     1        2  1      |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |             +  +                                                         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2  2     1     2  2  1  2  1  1     2  1     2  1  2  2  1  2  1  2  2   |             
      Duct, Dilatation                     |                      4                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         | 1  2     4  2  2  2  1        3     1           2  1  2  2     2  1      |             
      Epithelium, Hyperplasia              |                                                       2  1               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Atrophy                              | 3  4  3  2        3     3     4  2  4        3  3  2  2     4  3  4  4   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1     1     1  1        1  1                          1                 1|             
      Seminiferous Tubule, Atrophy         | 4  4     3  3     4  4  3     4  3  4        4  4  3  2     4  4  3  4  4|             
      Seminiferous Tubule, Mineralization  |    1              1  1  1     1     1                          1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Sternal, Autolysis                   |                                        2                                 |             
      Sternal, Myelofibrosis               |    1              2     2                                      2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|             
                                           | 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2,000                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +                       +  +  +                             +   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             1            |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |                                           1                             2|             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Congestion                           |                                                                         2|             
      Depletion Lymphoid                   | 4     4        3  3     3        4  4  4        1  3  4           3  3   |             
      Fibrosis                             |       3        1              3  2  1           3  2        1            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  I  +  +  +  +  +  +   |             
      Ectopic Parathyroid Gland            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Galactocele                          |       2                          2                                       |             
      Hyperplasia                          | 2  1  3  1           2  2     1  3  2  1     2  2     2  2  3  2  2  2   |             
      Inflammation, Chronic                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Foot, Acanthosis                     |                                                                          |             
      Foot, Hyperkeratosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cranium, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Gliosis                              |                                                                          |             
      Infarct                              | 1                                      1                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|             
                                           | 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2,000                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         1|             
      Foreign Body                         |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Mineralization               |    1  1        1              1                 1                 1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         | 4  4     1  1        2  1     1  2     1        1     1  4  3     1  3   |             
      Metaplasia, Squamous                 | 2  3                             2                       1     2     2   |             
      Lumen, Foreign Body                  |                                                          1  1        1   |             
      Mucosa, Ulcer                        |                                  2                    2  2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                        2                                 |             
      Cyst                                 |       2                                         1                        |             
      Nephropathy                          | 2  2  4  2  1  3  4  4  2  2  2  3  2  2  3  3  4  2  2  1  3  3  3  2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                             1            |             
      Transitional Epithelium, Hyperplasia |                1     2           1                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                        3                                 |             
      Polyarteritis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5|                                            |            |
                                           | 0| 3| 6| 2| 9| 0| 0| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |       3              3                                                   |      3  3.0|
      Hyperplasia, Glandular               |                                                                          |      1  4.0|
      Parasite Metazoan                    | 1                       1                                                |     11  1.1|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
      Submucosa, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |       3              2                                                   |      3  2.7|
      Parasite Metazoan                    |                   1     1                                                |     14  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |       3                                                                  |      2  3.0|
      Parasite Metazoan                    |             1           1                                                |      5  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |       3              2                                                   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |       3              2                                                   |      4  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.0|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |       3              3                                                   |      3  3.3|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Muscularis, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  57        |
      Angiectasis                          |                   2                                                      |      3  1.7|
      Basophilic Focus                     | X              X        X                                                |      7     |
      Clear Cell Focus                     |                                                                          |      3  1.0|
      Degeneration                         |                   1                                                      |      6  1.0|
      Eosinophilic Focus                   |                   X                                                      |      6  2.0|
      Fatty Change                         |                                                                          |      8  1.3|
      Hepatodiaphragmatic Nodule           |          X                                                               |      6     |
      Hyperplasia                          |                                                                          |      4  3.3|
      Inflammation, Chronic Active         | 1                                                                        |     13  1.2|
      Mixed Cell Focus                     |                                                                          |      1     |
      Pigmentation                         |          1                                                               |      2  1.5|
      Bile Duct, Hyperplasia               | 1  2  1  1     1  2  1                                                   |     48  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5|                                            |            |
                                           | 0| 3| 6| 2| 9| 0| 0| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis, Liquifactive               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +                                                   |  50        |
      Autolysis                            |       2                                                                  |      2  2.5|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1        1     1                                                         |     19  1.1|
      Polyarteritis                        |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                      2                                                   |      7  1.6|
      Acinus, Atrophy                      | 1  1     1     1                                                         |     22  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +                                                   |  49        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      8  1.8|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             | 2                                                                        |     13  1.5|
      Submandibular Gland, Fibrosis        |                                                                          |      1  2.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  | 1        1                                                               |     12  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      5  1.0|
      Hyperplasia, Squamous                |                                                                          |      5  2.2|
      Ulcer                                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      3  1.3|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
      Mucosa, Dilatation                   | 1  1     1     2  1  1                                                   |     45  1.2|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +                                                   |  50        |
      Cardiomyopathy                       | 3  1  3  2        2  3                                                   |     48  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5|                                            |            |
                                           | 0| 3| 6| 2| 9| 0| 0| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +                                                   |  50        |
      Angiectasis                          |                                                                          |      6  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      3  1.3|
      Vacuolization Cytoplasmic            |          1     1                                                         |     16  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +                                                   |  50        |
      Hyperplasia                          |    1                                                                     |      8  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +                                                   |  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +                                                   |  47        |
      Hyperplasia                          |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +                                                   |  51        |
      Pars Distalis, Autolysis             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |       1                                                                  |      4  1.3|
      Pars Distalis, Hyperplasia           |    2              1                                                      |     19  1.6|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +                                                   |  50        |
      Pigmentation                         |                                                                          |      2  1.0|
      C-Cell, Hyperplasia                  | 1  1     2                                                               |     20  1.4|
      Follicular Cell, Cyst                |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +                                                   |  50        |
      Inflammation, Chronic Active         | 1                                                                        |      3  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +                                                   |  51        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1  1  2  1     2  1  2                                                   |     46  1.5|
      Duct, Dilatation                     |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +                                                   |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5|                                            |            |
                                           | 0| 3| 6| 2| 9| 0| 0| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                1                                                         |     26  1.7|
      Epithelium, Hyperplasia              |          1                                                               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +                                                   |  50        |
      Atrophy                              |                3  1                                                      |     34  3.1|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +                                                   |  53        |
      Polyarteritis                        |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |    1  1        1     1                                                   |     27  1.0|
      Seminiferous Tubule, Atrophy         | 3              4  4  3                                                   |     41  3.6|
      Seminiferous Tubule, Mineralization  |                      1                                                   |     20  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +                                                   |  50        |
      Sternal, Autolysis                   |                                                                          |      1  2.0|
      Sternal, Myelofibrosis               |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      | 2                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +     +  +  +                                                |  15        |
      Hemorrhage                           |             1           3                                                |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.3|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.0|
      Sinus, Ectasia                       |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1                                             |     58  1.0|
      Pigmentation                         |             1           1  1                                             |     10  1.1|
      Sinus, Ectasia                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  52        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Depletion Lymphoid                   |    3                 4                                                   |     17  3.2|
      Fibrosis                             |                                                                          |     10  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +                                                   |  48        |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +     +  M  M                                                   |  39        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5|                                            |            |
                                           | 0| 3| 6| 2| 9| 0| 0| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                                                                          |      3  2.0|
      Hyperplasia                          |          1     2                                                         |     36  1.8|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +                                                   |  51        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
      Foot, Acanthosis                     |                                                                          |      1  1.0|
      Foot, Hyperkeratosis                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +                                                   |  50        |
      Cranium, Hyperostosis                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +                                                   |  50        |
      Gliosis                              |                                                                          |      1  1.0|
      Infarct                              |    2                 3                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  57        |
      Congestion                           |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      8  1.1|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Artery, Mineralization               |    1     1  1  1        1                                                |     24  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +                                                   |  50        |
      Inflammation, Chronic Active         | 1     1                                                                  |     31  1.9|
      Metaplasia, Squamous                 |                                                                          |     10  2.1|
      Lumen, Foreign Body                  |                                                                          |      4  1.3|
      Mucosa, Ulcer                        |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +        +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5|                                            |            |
                                           | 0| 3| 6| 2| 9| 0| 0| 3| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2,000                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  52        |
      Autolysis                            |                                                                          |      1  2.0|
      Cyst                                 |                2                                                         |      4  1.8|
      Nephropathy                          | 2  2  2  2     4  3  2  2                                                |     52  2.6|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             | 1                                                                        |      5  1.0|
      Transitional Epithelium, Hyperplasia |                1  2                                                      |     16  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +                                                   |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Polyarteritis                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|             
                                           | 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    | 1     1     1              1           1              1                  |             
      Polyarteritis                        |                                                                          |             
      Ulcer                                |                1                                                         |             
      Epithelium, Pigmentation             |                                           1                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                   1        1     1     1     1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                               1                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |       4                                                                  |             
      Hyperplasia, Glandular               |       2                                                                  |             
      Inflammation, Chronic Active         |       4                                                                  |             
      Ulcer, Multiple                      |       4                                                                  |             
      Epithelium, Pigmentation             |                         1                             1                  |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
      Submucosa, Inflammation, Acute       |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |          3                                                               |             
      Muscularis, Hyperplasia              |          3                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |          2           1                 1        1                        |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     | X  X                                                     X        X      |             
      Clear Cell Focus                     | X  X                                                                     |             
      Degeneration                         | 1                 1  1        1  1           1                 2  1  1   |             
      Eosinophilic Focus                   |          X                    X        X     1                           |             
      Fatty Change                         |                                                                2  1      |             
      Hepatodiaphragmatic Nodule           |                                                          X               |             
      Hyperplasia                          |                                  3  2                                    |             
      Inflammation, Chronic Active         | 1     1                 1                 1              1               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                      1                                                   |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|             
                                           | 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  1  2  2  1  1  2        1     1  1  1  1  1  1        3  2  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +                    +        +                           |             
      Fibrosis                             |    2           4                             2                           |             
      Inflammation, Chronic Active         |    2           4                             2                           |             
      Necrosis, Liquifactive               |    2           4                             3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                     2                                    |             
      Inflammation, Chronic Active         | 1     1                       1        1                    1     1      |             
      Polyarteritis                        |       4  2                                                               |             
      Vacuolization Cytoplasmic            |                   2                             1                        |             
      Acinus, Atrophy                      |       1     1  1  2  1        2  1  2                       2     1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |    1  1     1                                               1            |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |    1                                                        1            |             
      Submandibular Gland, Necrosis,       |                                                                          |             
          Coagulative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lamina Propria, Inflammation,        |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                     2                             2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                4                                                         |             
      Epithelium, Pigmentation             |                                                                          |             
      Mucosa, Dilatation                   | 2  2  2  1  2  1  1  1        2  2  1  1           2        1  1         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|             
                                           | 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Cardiomyopathy                       | 3  2  2  2  2  2  2  2        2  2  2  2     2  2  2        2  3  2     2|             
      Atrium, Thrombosis                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +     +  +  +  +     +|             
      Capsule, Thrombosis                  |                1                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +  +  +     +     +     +  +  +  +     +|             
      Angiectasis                          |    2  1                                                                  |             
      Autolysis                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hyperplasia                          | 1                                                           1            |             
      Vacuolization Cytoplasmic            | 1                 1                 1  1           1                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +     +  +  +  +     +|             
      Autolysis                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hyperplasia                          |             1                          1     1  2           1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Hyperplasia                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Pars Distalis, Angiectasis           | 2                                               1                        |             
      Pars Distalis, Cyst                  |       1                                                                  |             
      Pars Distalis, Hyperplasia           | 1           2        2                             1              2     1|             
      Pars Intermedia, Angiectasis         |                                                                3         |             
      Pars Intermedia, Cyst                |             1                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +     +  +  +  +     +|             
      Autolysis                            |                                                                          |             
      Pigmentation                         |                                                    1                     |             
      C-Cell, Hyperplasia                  | 1           1  1  2  1        1     2              1                     |             
      Follicular Cell, Cyst                |                                  2                                       |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +     +  +  +  +     +|             
      Inflammation, Chronic                |                                                          1               |             
      Inflammation, Chronic Active         | 2  2  2  2  2  2  2  2        2  2  2  1     1  1  1        1  2  1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|             
                                           | 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |             1                 2  1  1  1     2  1  3              1      |             
      Epithelium, Hyperplasia              |          1                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Atrophy                              |    2  3  2  2  3  2  2        2  2  3  3     3  3  2        2  3         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +     +|             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                2                                                         |             
      Interstitial Cell, Hyperplasia       | 1        1     1     1  1        1           1  1  1     2  1     1      |             
      Seminiferous Tubule, Atrophy         | 3  4  4  2  4  4  4           4  4  4  3     4  3  3     1  4  4         |             
      Seminiferous Tubule, Mineralization  |                   1              1     1        1           1     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +        +  +  +  M     +  +  +        +  +  +     +|             
      Sternal, Myelofibrosis               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hyperplasia, Lymphoid     | 2                                                                        |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |          1                                                               |             
      Pancreatic, Sinus, Ectasia           |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +  +  +        +        +        +  +           +        +   |             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                            1                                         3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              2  1                        |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2           2      |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  1  1  1  2  2  1  1  1  1  1|             
      Pigmentation                         |                         1  1              1           1  1           1   |             
      Sinus, Ectasia                       | 1     3                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |    2           2  4              2  2  1                    2  4         |             
      Fibrosis                             |    2  2  2  2  1     1                 3                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|             
                                           | 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +        +  +  +  +     +  M  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                  1                                       |             
      Depletion Lymphoid                   |                                                                          |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  +  +  +  +        +  +  +  +     +  +  +        M  +  +     +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 1        2  2  2     1        3  1  1  2     2  2  2           3  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |       2                                                                  |             
      Hyperkeratosis                       |       4                                                                  |             
      Subcutaneous Tissue, Necrosis,       |                                                                          |             
          Liquifactive                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +        +  +  +  M     +  +  +        +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Infarct                              |                                                                          |             
      Thrombosis                           |                      2                                                   |             
      Cerebrum, Infarct                    |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |             1                 1                             1  1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                                                    4                     |             
      Alveolar Epithelium, Hyperplasia     |       2              2                       2  1                        |             
      Artery, Mineralization               |    1  1        1     1        1  1  1  1  1           1     1        1   |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  +  +  +  +        +  +  +  +  +  +  +  +        +  +  +     +|             
      Inflammation, Chronic Active         |       4  1  3        3        2  1  3  1     1  3  1        2  1  1     2|             
      Metaplasia, Squamous                 |             2        2                                                  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|             
                                           | 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Hyperplasia                  |                                           2                              |             
      Lumen, Foreign Body                  |                                                                         1|             
      Lumen, Inflammation, Acute           |                                           4                              |             
      Mucosa, Ulcer                        |                                                 3                       1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                                            +                     |             
      Cataract                             |    4                                                                     |             
      Retina, Degeneration                 |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
      Cyst                                 |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Abscess                              |                                                                          |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                        1                          2      |             
      Nephropathy                          | 4  3  2  3  3  2  2  2        4  3  3  4     3  4  2        4  2  3     2|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |             1                       1  1                                 |             
      Renal Tubule, Hyperplasia            |                               1                                          |             
      Transitional Epithelium, Hyperplasia | 1           1                       1        1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +        +  +  +     +|             
      Autolysis                            |                                                                          |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Cyst                                 |    4                                                                     |             
      Inflammation, Chronic Active         |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|             
                                           | 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       4                                             |             
      Parasite Metazoan                    | 1        1     1                    1           1  1                 1  1|             
      Polyarteritis                        |                               3                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       4                                             |             
      Parasite Metazoan                    | 1     1  1     2                    1           1                       1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       4                                             |             
      Parasite Metazoan                    | 1     1  1                                                              1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       4                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       4                                             |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer, Multiple                      |                                                                          |             
      Epithelium, Pigmentation             |                                           1                              |             
      Peyer's Patch, Hyperplasia           |                                                                         2|             
      Submucosa, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       4                                             |             
      Inflammation, Chronic                |                                                                          |             
      Muscularis, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                1         |             
      Autolysis                            |                            3                                             |             
      Basophilic Focus                     | X              X                                X              X  X      |             
      Clear Cell Focus                     |                                                                X         |             
      Degeneration                         | 1              2  1                 1           1  2           1         |             
      Eosinophilic Focus                   |                X                                                  X      |             
      Fatty Change                         |                                                       2                  |             
      Hepatodiaphragmatic Nodule           |                            X                       X        X  X         |             
      Hyperplasia                          |                                                                      3   |             
      Inflammation, Chronic Active         | 1                                                           1           1|             
      Mixed Cell Focus                     | 1                 X                             X  X                     |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|             
                                           | 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Bile Duct, Hyperplasia               | 1     2  1  1  1  1  1  1     1  2  1  1     1  1  1  3     1  1  1  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +  +        +        +                  |             
      Fibrosis                             |                                  4           3        3                  |             
      Inflammation, Chronic Active         |                                  2           2                           |             
      Necrosis, Liquifactive               |                                  4           3        4                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |    2                       4                                             |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic Active         | 1                 1                             1           1            |             
      Polyarteritis                        |          2                                                               |             
      Vacuolization Cytoplasmic            |                                                       1              2   |             
      Acinus, Atrophy                      | 2        2  4  1     1           1     2        1     1     1  1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                  2                          1            |             
      Duct, Submandibular Gland,           |                                                                          |             
          Inflammation, Chronic Active     |                1                                                         |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |                1                                                         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  | 1                                1                 2     1  1     1      |             
      Submandibular Gland, Necrosis,       |                                                                          |             
          Coagulative                      |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lamina Propria, Inflammation,        |                                                                          |             
          Chronic Active                   |                                                          1               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +  I  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Hyperkeratosis                       |                                     1                 1                  |             
      Hyperplasia, Squamous                |                                     2                 2                  |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Ulcer                                |                                     4                 2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                       3                                             |             
      Fibrosis                             |                                                       2                  |             
      Hemorrhage                           |                                                       1                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Necrosis, Coagulative                |                                                       2                  |             
      Epithelium, Pigmentation             |                                                       2                 1|             
      Mucosa, Dilatation                   | 2     2  1     1  1  1  1        1  2  1        1     1     1  1  2  2   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|             
                                           | 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 2  3  1  2  1  2  2  2  2  2  2  2  2  1     1  2  2        3  2  2  2   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Capsule, Thrombosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                   1                                                      |             
      Autolysis                            |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                1         |             
      Vacuolization Cytoplasmic            |          2        1  2           1  2  1     1        3     1        2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2     1           1              1                    1     2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |    2                                            1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                   1           2  3                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                               3                                          |             
      Pars Distalis, Hyperplasia           |             1           1     2        1           2     1     2         |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            4                                             |             
      Pigmentation                         |                                                                          |             
      C-Cell, Hyperplasia                  | 2                    1        1     1           1  2  1           1  1   |             
      Follicular Cell, Cyst                |                2                                                         |             
      Follicular Cell, Hyperplasia         |                                     1  1           2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                            +                             +               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1     1  1     4  2  2  1     2  2  2  1     1  1  2     1     2  2  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|             
                                           | 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Inflammation, Chronic Active         | 3  3  1  1  1  3     2                                         2  1  1   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Atrophy                              | 2     3     1     3  3        3     3  2        2           3  2  3  3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |    1     1  1        1  1        1     1  1        1                 1   |             
      Seminiferous Tubule, Atrophy         | 4  1  3        4  4           4     4  3  4     4  3        4  3  4  3   |             
      Seminiferous Tubule, Mineralization  | 1     1        1  1                 1     1     1           1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Sternal, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Mediastinal, Pigmentation            |                                           1                              |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +        +  +  +                                         +   |             
      Autolysis                            |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            4                                             |             
      Hemorrhage                           |                                           1                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1        1  1  1  1     1  1  1  1  2  1  1  1     1|             
      Pigmentation                         |                                                                         1|             
      Sinus, Ectasia                       |                3        3                 2        2                 2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Depletion Lymphoid                   |       3  4  3  2     2  3  2  3  3  3  4              4              4   |             
      Fibrosis                             |                1              2     2                                1   |             
      Hyperplasia, Lymphoid                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|             
                                           | 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            3                                             |             
      Cyst                                 |                                  1                                       |             
      Depletion Lymphoid                   |                                                          2               |             
      Ectopic Parathyroid Gland            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  M  M     M  +  +  M  +  +  +  M  +   |             
      Galactocele                          |                                  3                                       |             
      Hyperplasia                          | 2        1  2  2  2  3  1  2  2  3              2  1        2  1     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Abscess                              |    4                                                                     |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Necrosis,       |                                                                          |             
          Liquifactive                     |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Infarct                              |             3                          2                                 |             
      Thrombosis                           |                                                                          |             
      Cerebrum, Infarct                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            2                                             |             
      Fibrosis                             |                                        1                                 |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                           1                              |             
      Infiltration Cellular, Histiocyte    | 1     1                                               1              1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |                1              1                          1     1         |             
      Bronchiole, Epithelium, Hyperplasia  |                                                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         | 1  3  3  1  1  1  2  2        1  1              1  1  1  4  2     4  3   |             
      Metaplasia, Squamous                 |                                                                   3  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|             
                                           | 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10,000                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Hyperplasia                  |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Inflammation, Acute           |                                                                          |             
      Mucosa, Ulcer                        |                                                             1     2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    I                                   +                                 |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                       2                  |             
      Autolysis                            |    3                       4                                             |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2  3  2  2  3  3  3  2     4  4  4  2     1  3  3  2     2  2  3  3   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             | 1                                1              1           1        1   |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1  1              2           1  1              1  1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                            4                                             |             
      Calculus Gross Observation           |                                        X                                 |             
      Calculus Micro Observation Only      |                      3                       2                           |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
      Parasite Metazoan                    |    1              1                                                      |     16  1.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.5|
      Parasite Metazoan                    |    1                       1                                             |     14  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  3.5|
      Parasite Metazoan                    | 1  1                                                                     |      7  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.5|
      Fibrosis                             | 2                                                                        |      2  3.0|
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Ulcer, Multiple                      |                                                                          |      1  4.0|
      Epithelium, Pigmentation             |                            1                                             |      4  1.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
      Submucosa, Inflammation, Acute       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Muscularis, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +                                             |  56        |
      Angiectasis                          |                                                                          |      5  1.2|
      Autolysis                            |                                                                          |      1  3.0|
      Basophilic Focus                     |                   X                                                      |     10     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration                         |                1                                                         |     17  1.2|
      Eosinophilic Focus                   |                   X                                                      |      7  1.0|
      Fatty Change                         |    1  2                 2                                                |      6  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 112                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      3  2.7|
      Inflammation, Chronic Active         |                      1                                                   |      9  1.0|
      Mixed Cell Focus                     | X                                                                        |      5  1.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Pigmentation                         |    1                                                                     |      2  1.0|
      Bile Duct, Hyperplasia               | 1  1  1  1        1  1  1                                                |     45  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Fibrosis                             |                                                                          |      6  3.0|
      Inflammation, Chronic Active         |                                                                          |      5  2.4|
      Necrosis, Liquifactive               |                                                                          |      6  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      2  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |     10  1.0|
      Polyarteritis                        | 3                                                                        |      4  2.8|
      Vacuolization Cytoplasmic            |    1              1                                                      |      6  1.3|
      Acinus, Atrophy                      | 1  1                 1                                                   |     24  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +                                                |  50        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                      1                                                   |      3  1.3|
      Duct, Submandibular Gland,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  1.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             |                                                                          |      5  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  | 1     1              1                                                   |     11  1.1|
      Submandibular Gland, Necrosis,       |                                                                          |            |
          Coagulative                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lamina Propria, Inflammation,        |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      2  1.0|
      Hyperplasia, Squamous                |                                                                          |      4  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 113                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      2  3.0|
      Epithelium, Pigmentation             |                            1                                             |      3  1.3|
      Mucosa, Dilatation                   | 2     1  1     1  2  1  1                                                |     38  1.4|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Cardiomyopathy                       | 2  2  2  1     3  3  1  1                                                |     48  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  51        |
      Capsule, Thrombosis                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Angiectasis                          | 1                                                                        |      4  1.3|
      Autolysis                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      3  1.0|
      Vacuolization Cytoplasmic            |       2                                                                  |     16  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  51        |
      Autolysis                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 1     1                                                                  |     13  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +                                                |  48        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +                                                |  49        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      2  1.5|
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |       2  2        2     1                                                |     17  1.5|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 114                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Autolysis                            |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |       1                                                                  |     18  1.2|
      Follicular Cell, Cyst                |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         |                1                                                         |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1  1  1  1     1  2  2  2                                                |     45  1.6|
      Duct, Dilatation                     |       3                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1  4  1  3           4                                                   |     24  1.8|
      Epithelium, Hyperplasia              |                1                                                         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +                                             |  51        |
      Atrophy                              | 3     3        2                                                         |     32  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  54        |
      Autolysis                            |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |    1     1  1  1  1  1  1                                                |     29  1.0|
      Seminiferous Tubule, Atrophy         | 4     4        3  3  2  2                                                |     38  3.4|
      Seminiferous Tubule, Mineralization  | 1     1        1  1  1  1                                                |     23  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +                                                |  49        |
      Sternal, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                            3                                             |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                                                                          |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 115                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      | 1                                                                        |      2  1.0|
      Pancreatic, Sinus, Ectasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +        +                                                      |  22        |
      Autolysis                            |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |    1                                                                     |      1  1.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  1.5|
      Sinus, Ectasia                       |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1                                             |     56  1.1|
      Pigmentation                         |             1              1                                             |      9  1.0|
      Sinus, Ectasia                       | 2           1                                                            |      9  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Depletion Lymphoid                   |    2  3  3        2     3                                                |     26  2.8|
      Fibrosis                             |       1                                                                  |     12  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  I  +  I     +  +  +  +                                                |  45        |
      Autolysis                            |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      2  1.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  M  +                                                |  40        |
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          | 1  2  2  1     2  2     2                                                |     36  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +                                                |  53        |
      Abscess                              |                                                                          |      1  4.0|
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Necrosis,       |                                                                          |            |
          Liquifactive                     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 116                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Cerebrum, Infarct                    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Foreign Body                         | 1                                                                        |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      8  1.0|
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                4                                                         |      5  2.2|
      Artery, Mineralization               | 1     1     1     1  1     1                                             |     22  1.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Chronic Active         | 4  1     2     2  3  1  1                                                |     39  1.9|
      Metaplasia, Squamous                 | 2        2     2  2                                                      |      9  2.0|
      Glands, Hyperplasia                  |                                                                          |      1  2.0|
      Lumen, Foreign Body                  | 2                                                                        |      2  1.5|
      Lumen, Inflammation, Acute           |                                                                          |      1  4.0|
      Mucosa, Ulcer                        |                                                                          |      4  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +  +                                                   |   7        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 117                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 6| 5| 4|                                            |            |
                             DAY ON TEST   | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5|                                            |            |
                                           | 5| 7| 3| 2| 6| 0| 2| 2| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10,000                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Abscess                              |                                                                          |      1  2.0|
      Autolysis                            |                                                                          |      2  3.5|
      Cyst                                 |                                                                          |      2  1.5|
      Nephropathy                          | 3  3  2  2     2  3  2  2                                                |     48  2.7|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |                                                                          |      8  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia | 2  1              1                                                      |     14  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      1  4.0|
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 118                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3           4                                                      |             
      Erosion                              |                                        1                                 |             
      Hyperplasia, Glandular               | 1        1  2  1        3     2  1  2  2  3  2  3  1  2  2  1  2  2     2|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Parasite Metazoan                    |                                                 1  1                     |             
      Ulcer                                |             4  2           3  1     3  1  1  2  2     2  2  1        4  2|             
      Ulcer, Multiple                      |                         4                                                |             
      Epithelium, Pigmentation             |                      1                                                   |             
      Lamina Propria, Inflammation, Chronic|                      1                                                   |             
      Mucosa, Ulcer                        |                                                                          |             
      Submucosa, Fatty Change              |                                                 4                        |             
      Submucosa, Lamina Propria,           |                                                                          |             
          Inflammation, Chronic Active     | 2           4  1        3  3  2  1  3  2  3  3        2  3           3  3|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3           4                                                      |             
      Hyperplasia, Glandular               |                            2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |             1                                                            |             
      Ulcer                                |                         4  4                                             |             
      Submucosa, Epithelium, Proliferation |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3           4                                                      |             
      Epithelium, Pigmentation             |                      1              1              1                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       2           4                                                  2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   4                                                  2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Pigmentation             |                                  1     1  1           1  1     1         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       4           2                                            3     2   |             
      Epithelium, Pigmentation             |                                                       1                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X        1        X  X        X     X        X           X  X  X  X      |             
      Clear Cell Focus                     |                                        X                                 |             
      Degeneration                         |    2           1                                                         |             
      Eosinophilic Focus                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 119                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fatty Change                         |    1                       2                    1                        |             
      Hepatodiaphragmatic Nodule           |                                                       X                  |             
      Hyperplasia                          |                                  2              1                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 1           1        1     1              1              1  1        1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                1  2      |             
      Bile Duct, Hyperplasia               | 1  1  1        1  1  1     1  1  2  1  1        1  1  1     1     1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                               +                       +|             
      Fibrosis                             | 2                                                                       2|             
      Inflammation, Chronic Active         | 4                                               2                       2|             
      Necrosis, Liquifactive               | 2                                               2                        |             
      Necrosis                             |                                                                         3|             
      Artery, Hyperplasia                  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Autolysis                            |                   2                                                      |             
      Cytoplasmic Alteration               |                                                                   2      |             
      Inflammation, Chronic                |                                           1           1                  |             
      Inflammation, Chronic Active         |                               1     1        2                 1  1  1   |             
      Pigmentation                         |                                                                         1|             
      Vacuolization Cytoplasmic            |    1                             1              1  2           2         |             
      Acinus, Atrophy                      |                1              1  1  1        1                 1  1  1   |             
      Acinus, Hyperplasia                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland, Dilatation|                                        2                                 |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      | 2                                1              1                        |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             | 1                                                                        |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Submandibular Gland, Atrophy         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                      1                                                   |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  | 1                                            1  1           1  1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |          1  2           2  4                 1                    2  2   |             
      Hyperplasia, Squamous                |          2  3           2  4                 1                    3  3   |             
      Inflammation, Chronic Active         |             1           1  2                 1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 120                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |          2                                                               |             
      Ulcer, Multiple                      |                                                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Autolysis                            |                   2                                                      |             
      Metaplasia, Squamous                 |                                                                          |             
      Necrosis, Coagulative                |                                                 2                        |             
      Epithelium, Pigmentation             |    1                                      1              1              1|             
      Mucosa, Dilatation                   | 1     1  1  1  1        1     1  1           1     1        1  2  1      |             
      Muscularis, Developmental            |                                                                          |             
          Malformation                     |                                           2                              |             
      Muscularis, Submucosa, Inflammation, |                                                                          |             
           Chronic Active                  |                                                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   2      |             
      Cardiomyopathy                       | 2  2  2  2  1  2  3  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2              1                                               1         |             
      Hematopoietic Cell Proliferation     |                                     1                                    |             
      Hyperplasia                          |                                           1                              |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative                |          1                                                               |             
      Vacuolization Cytoplasmic            |    3  1  2  2     1     3  3     2              1  1                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Hyperplasia                          | 2  2           2              1                    2           2         |             
      Necrosis, Coagulative                |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Autolysis             |                   3                                                      |             
      Pars Distalis, Cyst                  |                         1     1        1        2                        |             
      Pars Distalis, Hyperplasia           |             1  2        1  2  2           1  4        1           2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 121                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                                      |             
      Inflammation, Chronic Active         |                                                                      1   |             
      Pigmentation                         |                                     1                                    |             
      C-Cell, Hyperplasia                  |          1                                      1  1        1           1|             
      Follicle, Pigmentation               |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                     +        +  +              +         |             
      Atrophy                              |                                     1        3  3              3         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      1                    1                             1|             
      Inflammation, Chronic Active         | 1  2  1  1  2  1  2     2  1  1  1  1        2  1     1  1  2  2  1  1   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   2                                                      |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                      1                                3                  |             
      Inflammation, Chronic Active         | 2  3  4     3           2     2  2  2  1  2     2  3           4  2  1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        2  3  3              2  2  3        3  3  3           3  3      |             
      Autolysis                            |                   2                                                      |             
      Cyst                                 |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
      Interstitial Cell, Hyperplasia       |    1  1  1  1        2  1        1     2  2     1  1  1  1  1  1     1  2|             
      Seminiferous Tubule, Atrophy         | 4  4     4     4              4  3  4        4  4  3        3  4  4  1   |             
      Seminiferous Tubule, Mineralization  |                                  1  1              1        1     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Hypocellularity             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Hemorrhage               |                                           1                              |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 122                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Histiocyte                      |                                                                          |             
      Sinus, Ectasia                       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +                                         +  +     +        +      |             
      Hemorrhage                           |                                                          3               |             
      Hyperplasia, Lymphoid                |                                                                   4      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia, Lymphoid                |                         3                                                |             
      Infiltration Cellular, Histiocyte    | 2        1  1  1  1     1     1  1  1  1     1  1     1  1  2  1  1  1   |             
      Inflammation, Chronic Active         |             2              2                                             |             
      Pigmentation                         |                                        1                 1               |             
      Sinus, Ectasia                       | 4  2     3  2  3  3  3  4  3  3  2  3     4  3  4     3  4  4  4  3  4   |             
      Sinus, Ectasia, Multiple             |                                                                         4|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   3      |             
      Bacterium                            |                                                                   4      |             
      Depletion Lymphoid                   |          3                 2                    3              2  2      |             
      Fibrosis                             |                2                 1                          2     3      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   1                                                      |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                   4      |             
      Depletion Lymphoid                   |                      1     3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 2  2     1     1  2  1  2  2  1  2     1     2  2  2  2  1  1  2  1  2  2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   2                                                      |             
      Infarct                              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 123                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   2                                                      |             
      Bronchiectasis                       |                                                                          |             
      Foreign Body                         |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                    1           1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                   1                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                                                         3|             
      Artery, Mineralization               |                   1     1  1     1     1  1  1           1     1     1  1|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic Active         | 1  4  2  1     1        1        1           1  1  1              1      |             
      Metaplasia, Squamous                 |    2              2                       2                              |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                   2                                                      |             
      Mucosa, Ulcer                        |                   2                                                      |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active                  |                                           2                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                 +                                      +         |             
      Cataract                             |       3                                                                  |             
      Cornea, Neovascularization           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                         +                                                |             
      Inflammation, Chronic                |                         1                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   3      |             
      Autolysis                            |       3           3                             2                        |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 124                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|             
                                           | 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  2  2  2  1  2  2  1  2     2  2  1  2  1  2  2  2  1  1  2  3  2  1  2|             
      Adventitia, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                1  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                                      |             
      Calculus Gross Observation           |       X                                                                  |             
      Calculus Micro Observation Only      |                      2                                                   |             
      Inflammation, Chronic                |                                        1                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Subserosa, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 125                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperkeratosis                       |          2  2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 3                                                                        |             
      Erosion                              |                                                                          |             
      Hyperplasia, Glandular               |    2  1     1  2  2  2  2  2  2  3  3  2  2     3  3  3  2  2  2  2  2  1|             
      Inflammation, Chronic Active         | 4                                                                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                | 4  1  4           2        4  2        4  4     3     2     2           1|             
      Ulcer, Multiple                      |                                                                          |             
      Epithelium, Pigmentation             |                                                                          |             
      Lamina Propria, Inflammation, Chronic|                                                                          |             
      Mucosa, Ulcer                        |             4                                                            |             
      Submucosa, Fatty Change              |                                                                          |             
      Submucosa, Lamina Propria,           |                                                                          |             
          Inflammation, Chronic Active     |    2  4  1        2  1  2  4     1     4           1  2     3  2  2  2  2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Glandular               |          1                                2                    1         |             
      Inflammation, Chronic Active         |                                           4                    1         |             
      Parasite Metazoan                    |                                                                   1      |             
      Ulcer                                |       3  4  2                             4                              |             
      Submucosa, Epithelium, Proliferation |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 2                                                                        |             
      Epithelium, Pigmentation             |                               1                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 4                                                                        |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Inflammation, Chronic Active         |          1                                                               |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Autolysis                            | 2                                         2                              |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X           X  X     X     X           X        X  X     X            |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration                         |                                                                   1      |             
      Eosinophilic Focus                   |                      X        X                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 126                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fatty Change                         |             2              2                                             |             
      Hepatodiaphragmatic Nodule           |                X  X  X              X        X     X  X     X            |             
      Hyperplasia                          |                                                                   2      |             
      Inflammation, Acute                  |                                        2                                 |             
      Inflammation, Chronic Active         |    1  1  2  1           1     1           2     1              1         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               |          2     1  1  1     1  1  1  1        1  1     1  1  1     2  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       M  +              +                                                |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |          2                                                               |             
      Necrosis, Liquifactive               |                                                                          |             
      Necrosis                             |                                                                          |             
      Artery, Hyperplasia                  |                         3                                                |             
      Perivascular, Inflammation, Chronic  |                         2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         1                                                |             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic                |    1                    1                                                |             
      Inflammation, Chronic Active         |                   1                       1  1  1  1        1            |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                                  2                                       |             
      Acinus, Atrophy                      |          1                          1     2  1  1  2        1     2      |             
      Acinus, Hyperplasia                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland, Dilatation|                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Duct, Submandibular Gland,           |                                                                          |             
          Metaplasia, Squamous             |                   1  1  1                          1                     |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                    1                     |             
      Submandibular Gland, Atrophy         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |    2                    2                                                |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |       1           1  1                          1                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                1         |             
      Hyperkeratosis                       | 2     2  2  2              2           2  2                              |             
      Hyperplasia, Squamous                | 2     4  4  4              3           3  2                       1      |             
      Inflammation, Chronic Active         |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 127                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |          4                             1                                 |             
      Ulcer, Multiple                      |                                           4                              |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Autolysis                            |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Epithelium, Pigmentation             |                                                                          |             
      Mucosa, Dilatation                   |                1  1  1     2  1  1  1  1  1  1  1     1  2  1  2  2     1|             
      Muscularis, Developmental            |                                                                          |             
          Malformation                     |                                                                          |             
      Muscularis, Submucosa, Inflammation, |                                                                          |             
           Chronic Active                  |          1                                                               |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                         +                                      +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cardiomyopathy                       | 1  2  2  2  1  1  3  2  2  1  2  2  1        2  2  2  3  2  2  2  2  2   |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 1  1  1     1            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                    1                     |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            | 2     1  2  2     1        2           1  1              2     1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                1  1           2     1           2     1     2  2         |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               1                                          |             
      Pars Distalis, Autolysis             |                                                                          |             
      Pars Distalis, Cyst                  | 1              1                 1                                       |             
      Pars Distalis, Hyperplasia           |       2     1  2        1  2     2     2     2  1                 2  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 128                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                              1                           |             
      C-Cell, Hyperplasia                  |                   1           1                          1  2     2      |             
      Follicle, Pigmentation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                      +        +              +                           |             
      Atrophy                              |                      3        2              3                           |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                 |             
      Inflammation, Chronic Active         |    1           1  1        1  2  2  2        2  2  1  1  2  2  2  1  2  1|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                         2|             
      Inflammation, Acute                  |                                        4                                 |             
      Inflammation, Chronic Active         | 4  2  2     2  3  3  1        2  2        3  1     2  3  1  3  4  2  1  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     2              3     2  3  2  3        3  2  3  3  4        3      |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                            3                                             |             
      Epithelium, Hyperplasia              |                                  4                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Interstitial Cell, Hyperplasia       |    1  1        1  1     1     1     1  1  1  1     1  1        1  1  2  1|             
      Seminiferous Tubule, Atrophy         |                4  1  4        4  4  4  1     4  4  4  4     4  3  3     1|             
      Seminiferous Tubule, Mineralization  |          1     1     1           1              1  1     1  1     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Hypocellularity             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                         2                                                |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                   2      |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 129                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Histiocyte                      |                                              1                           |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                   +                 +                 +  +  +  +     +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       1        2        2|             
      Hyperplasia, Plasma Cell             |                   2                                         1            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1           1  1  2  1  1  1  1  1  1  1  1  1  2  1     1  1        1|             
      Inflammation, Chronic Active         | 2     4  4  2              4           3  4                             4|             
      Pigmentation                         |    1                    1                                                |             
      Sinus, Ectasia                       | 3  3  4  4  3  3  3  3  4  4  4  4  4  4  4  3  4  4  4  4  3  3  3  3  4|             
      Sinus, Ectasia, Multiple             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Bacterium                            |                                                                          |             
      Depletion Lymphoid                   | 4                                3  1                    3           2   |             
      Fibrosis                             |                   2                          1                    2      |             
      Hyperplasia, Lymphoid                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |          3  3           2                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Galactocele                          | 2                                                                        |             
      Hyperplasia                          | 3  2  2        2  3  2  2     1     1  2        2  1  2  2  2  2     2  2|             
      Pigmentation                         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Infarct                              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 130                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Bronchiectasis                       |                                                                          |             
      Foreign Body                         |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1                          1              1     1     1        1   |             
      Inflammation, Chronic Active         |                                                             1            |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  1                 2                     |             
      Artery, Mineralization               | 1  1  1     1  1        1     1     1     1     1              1  1      |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1                 1  4  1     1        1        1  3  4     1  4|             
      Metaplasia, Squamous                 |                               2                             2  2        2|             
      Lumen, Foreign Body                  |                                                          1               |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
      Mucosa, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                   2                                2  2           2      |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                   3                                2  3           2      |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     | M     +                             +  +           +  M           +      |             
      Cataract                             |                                                                          |             
      Cornea, Neovascularization           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |       +                                                                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Autolysis                            |                                                                          |             
      Cyst                                 |    1                                                                     |             
      Inflammation, Chronic                |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 131                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|             
                                           | 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50,000                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1  1     1  2  4  2  2  2  2  2  2  1  1  3  2  2  3  3  3  4  2  2  2|             
      Adventitia, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                1  1           1                 1           1  1         |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Transitional Epithelium, Hyperplasia |          2                       1              1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      | 3              2                                                         |             
      Inflammation, Chronic                |                                  1                                       |             
      Inflammation, Chronic Active         |                                                                1         |             
      Subserosa, Mineralization            |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 132                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Hyperkeratosis                       |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      3  3.3|
      Erosion                              |                                                                          |      1  1.0|
      Hyperplasia, Glandular               | 2  1  2  3     2  2     2  1                                             |     49  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Metaplasia, Osseous                  | 2                                                                        |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2  1.0|
      Ulcer                                | 2  1     2     4  2     2                                                |     32  2.4|
      Ulcer, Multiple                      |                                                                          |      1  4.0|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
      Lamina Propria, Inflammation, Chronic|                                                                          |      1  1.0|
      Mucosa, Ulcer                        |                                                                          |      1  4.0|
      Submucosa, Fatty Change              |                                                                          |      1  4.0|
      Submucosa, Lamina Propria,           |                                                                          |            |
          Inflammation, Chronic Active     | 2  1     3     3  2                                                      |     36  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                            2                                             |      3  3.0|
      Hyperplasia, Glandular               |                                                                          |      4  1.5|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Parasite Metazoan                    |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      6  3.5|
      Submucosa, Epithelium, Proliferation |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Autolysis                            |                            2                                             |      4  2.8|
      Epithelium, Pigmentation             |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      3  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Epithelium, Pigmentation             |          2                                                               |      7  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      6  2.5|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 133                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |    X           X                                                         |     22  1.0|
      Clear Cell Focus                     |    X                                                                     |      2     |
      Degeneration                         |                                                                          |      3  1.3|
      Eosinophilic Focus                   |                                                                          |      3     |
      Fatty Change                         |       2                    2                                             |      7  1.7|
      Hepatodiaphragmatic Nodule           | X                       X                                                |     11     |
      Hyperplasia                          |                                                                          |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |          1                                                               |     19  1.1|
      Mixed Cell Focus                     | X                                                                        |      1     |
      Necrosis, Coagulative                |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               | 1  1  2  1  1  1  1  2  1  1                                             |     43  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +                                             |   7        |
      Fibrosis                             |                            2                                             |      3  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  2.5|
      Necrosis, Liquifactive               |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Artery, Hyperplasia                  |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |          1                                                               |      3  1.3|
      Autolysis                            |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Inflammation, Chronic                |          1                                                               |      5  1.0|
      Inflammation, Chronic Active         | 1           2     1     1                                                |     16  1.1|
      Pigmentation                         |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      6  1.5|
      Acinus, Atrophy                      | 2                 2  2  1                                                |     20  1.3|
      Acinus, Hyperplasia                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Duct, Submandibular Gland, Dilatation|                                                                          |      1  2.0|
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      3  1.3|
      Duct, Submandibular Gland,           |                                                                          |            |
          Metaplasia, Squamous             |    1                                                                     |      6  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
      Submandibular Gland, Atrophy         |    2           1                                                         |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 134                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      3  1.7|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |    2           1                                                         |     11  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |       3     2                                                            |     16  2.1|
      Hyperplasia, Squamous                |       4     1              1                                             |     18  2.6|
      Inflammation, Chronic Active         |             2                                                            |      6  1.3|
      Ulcer                                |       3           1                                                      |      5  2.2|
      Ulcer, Multiple                      |                                                                          |      1  4.0|
      Submucosa, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |          2                                                               |      1  2.0|
      Necrosis, Coagulative                |                            2                                             |      2  2.0|
      Epithelium, Pigmentation             |                      1                                                   |      5  1.0|
      Mucosa, Dilatation                   |    1  1        2  1  2  2                                                |     36  1.2|
      Muscularis, Developmental            |                                                                          |            |
          Malformation                     |                                                                          |      1  2.0|
      Muscularis, Submucosa, Inflammation, |                                                                          |            |
           Chronic Active                  |                                                                          |      1  1.0|
      Submucosa, Inflammation, Chronic     |                                                                          |            |
          Active                           |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  2.0|
      Cardiomyopathy                       | 2  2  2  2  2  2  3  2  2  2                                             |     57  1.9|
      Congestion                           |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 2  1                                                                     |      9  1.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 135                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    1                                                                     |      3  1.0|
      Necrosis, Coagulative, Focal         |             2                                                            |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |       2                    2                                             |     22  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |                            1                                             |     15  1.6|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Angiectasis           |                                                                          |      1  1.0|
      Pars Distalis, Autolysis             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |          1                                                               |      8  1.1|
      Pars Distalis, Hyperplasia           |    1              1     1                                                |     26  1.6|
      Pars Intermedia, Cyst                | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                            2                                             |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      2  1.0|
      C-Cell, Hyperplasia                  |    1              1     1                                                |     13  1.2|
      Follicle, Pigmentation               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +     +                                                                  |   9        |
      Atrophy                              | 3                                                                        |      8  2.6|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Inflammation, Chronic Active         | 2  1  1     1     1  1     2                                             |     44  1.4|
      Duct, Dilatation                     |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 136                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 2  1  2  1  1     3  2                                                   |     41  2.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              | 3  2           2  3        3                                             |     30  2.7|
      Autolysis                            |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       | 1     1  1        1  1  2                                                |     39  1.2|
      Seminiferous Tubule, Atrophy         | 4  4           4  4  3     4                                             |     35  3.5|
      Seminiferous Tubule, Mineralization  |    1              1  1     1                                             |     18  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sternal, Hypocellularity             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +           +     +                                             |  17        |
      Hemorrhage                           |          2                                                               |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |             4                                                            |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1  1     1     1  1     1                                                |     43  1.1|
      Inflammation, Chronic Active         |                                                                          |     10  3.1|
      Pigmentation                         |          1                                                               |      5  1.0|
      Sinus, Ectasia                       | 3  4  3  3  4  2  4  3  3  3                                             |     56  3.4|
      Sinus, Ectasia, Multiple             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Abscess                              |                                                                          |      1  3.0|
      Bacterium                            |                                                                          |      1  4.0|
      Depletion Lymphoid                   |             1        3     2                                             |     13  2.4|
      Fibrosis                             |                                                                          |      7  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 137                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  +  +  +                                             |  52        |
      Autolysis                            |                                                                          |      1  1.0|
      Congestion                           |             4                                                            |      1  4.0|
      Cyst                                 |                                                                          |      1  4.0|
      Depletion Lymphoid                   |             3                                                            |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +                                             |  50        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          | 2        2     1  2  3  2  2                                             |     46  1.8|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
      Infarct                              |                   2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
      Bronchiectasis                       |                         3                                                |      1  3.0|
      Foreign Body                         |                         2                                                |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1     1     1     1                                                   |     12  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Artery, Mineralization               | 1  1     1           1                                                   |     27  1.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         | 2  4  2     3  1  2  2  3  2                                             |     31  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 138                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Squamous                 |    3                    2                                                |      9  2.1|
      Lumen, Foreign Body                  |                         3                                                |      2  2.0|
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Mucosa, Ulcer                        | 2  3                                                                     |      3  2.3|
      Mucosa, Submucosa, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      4  2.0|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |                                                                          |      4  2.5|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   9        |
      Cataract                             |                                                                          |      1  3.0|
      Cornea, Neovascularization           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Autolysis                            |             2              2                                             |      5  2.4|
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |             1                                                            |      1  1.0|
      Nephropathy                          | 2  2  2  2     2  2  2  2  2                                             |     57  1.9|
      Adventitia, Inflammation, Chronic    |                                                                          |            |
          Active                           |             1                                                            |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |                                                                          |      6  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |             1                                                            |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 139                                                               
NTP Experiment-Test: 05084-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TURMERIC, OLEORESIN (CURCUMIN)                              Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 07:39:35  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 7| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2|                                            |            |
                                           | 9| 9| 8| 6| 1| 9| 5| 2| 2| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50,000                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    PPM MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      3  2.3|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Subserosa, Mineralization            |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 140                                                               
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