National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3556

TDMS Study 05085-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         MANGANESE SULFATE


NTP Experiment-Test: 05085-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 04:58:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 19           20           19           19                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2                         6            5                                     
    Moribund Sacrifice                                 6            4            6            4                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           46           38           42                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    70           61           62           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (70)         (60)         (59)         (69)                                   
      Basophilic Focus                                 1 (1%)       7 (12%)      3 (5%)       5 (7%)                                
      Clear Cell Focus                                              5 (8%)       2 (3%)                                             
      Congestion                                                                              1 (1%)                                
      Cytomegaly, Multifocal                           1 (1%)                                                                       
      Eosinophilic Focus                               8 (11%)      8 (13%)      3 (5%)       4 (6%)                                
      Hepatodiaphragmatic Nodule                                                 2 (3%)                                             
      Infarct                                                       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Focal                                    2 (3%)                                                          
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       1 (1%)                                
      Mixed Cell Focus                                                                        3 (4%)                                
      Vacuolization Cytoplasmic                        6 (9%)       3 (5%)       7 (12%)      4 (6%)                                
      Hepatocyte, Atrophy                              1 (1%)                                                                       
      Kupffer Cell, Hyperplasia                        1 (1%)                                                                       
   Mesentery                                          (8)          (3)          (1)                                                 
      Fat, Inflammation, Chronic Active                6 (75%)      2 (67%)      1 (100%)                                           
   Pancreas                                           (70)         (50)         (50)         (69)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Acinus, Atrophy                                  1 (1%)       4 (8%)       2 (4%)                                             
      Duct, Cyst                                                    2 (4%)       1 (2%)       1 (1%)                                
   Salivary Glands                                    (70)         (50)         (50)         (68)                                   
      Infiltration Cellular, Lymphocyte                1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (50)         (50)         (68)                                   
      Erosion, Focal                                                                          2 (3%)                                
      Hyperplasia, Focal, Squamous                     1 (1%)       3 (6%)       4 (8%)      11 (16%)                               
      Inflammation, Chronic Active                                  1 (2%)                    4 (6%)                                
      Ulcer                                            2 (3%)                    1 (2%)       3 (4%)                                
   Stomach, Glandular                                 (70)         (50)         (51)         (67)                                   
      Degeneration                                     1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (1%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (50)         (69)                                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (50)         (50)         (69)                                   
      Corticomedullary Junction, Vacuolization                                                                                      
          Cytoplasmic                                                            1 (2%)                                             
   Adrenal Gland, Cortex                              (70)         (50)         (48)         (69)                                   
      Hyperplasia                                      4 (6%)       7 (14%)      6 (13%)      5 (7%)                                
      Hypertrophy                                      2 (3%)       4 (8%)       6 (13%)      5 (7%)                                
      Mineralization                                                             1 (2%)                                             
      Vacuolization Cytoplasmic                        2 (3%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (70)         (50)         (48)         (69)                                   
      Cyst                                             1 (1%)                                                                       
      Hyperplasia                                      1 (1%)       2 (4%)                                                          
   Islets, Pancreatic                                 (70)         (50)         (50)         (69)                                   
      Hyperplasia                                                                             1 (1%)                                
   Pituitary Gland                                    (67)         (46)         (50)         (67)                                   
      Pars Distalis, Cyst                              3 (4%)       3 (7%)       1 (2%)       1 (1%)                                
      Pars Distalis, Hyperplasia                       6 (9%)       7 (15%)      4 (8%)      10 (15%)                               
   Thyroid Gland                                      (69)         (50)         (52)         (70)                                   
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (1%)       2 (4%)       3 (6%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Follicle, Cyst                                  18 (26%)     12 (24%)      9 (17%)      7 (10%)                               
      Follicle, Dilatation                             1 (1%)       5 (10%)     12 (23%)     36 (51%)                               
      Follicular Cell, Hyperplasia, Diffuse            1 (1%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia, Focal              3 (4%)      15 (30%)     27 (52%)     43 (61%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (69)         (51)         (53)         (69)                                   
      Atrophy                                          2 (3%)                                                                       
      Fibrosis                                                                                1 (1%)                                
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                                                 1 (2%)                                             
      Bilateral, Atrophy                               1 (1%)                                                                       
      Bilateral, Follicle, Cyst                        1 (1%)                                 1 (1%)                                
      Follicle, Cyst                                  19 (28%)     19 (37%)     18 (34%)     14 (20%)                               
      Periovarian Tissue, Cyst                         3 (4%)       2 (4%)       3 (6%)       9 (13%)                               
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                                                              1 (1%)                                
      Rete Ovarii, Cyst                                                                       1 (1%)                                
   Uterus                                             (70)         (52)         (54)         (69)                                   
      Hemorrhage                                       1 (1%)                                                                       
      Cervix, Inflammation, Chronic Active                                                    1 (1%)                                
      Endometrium, Angiectasis                                                                1 (1%)                                
      Endometrium, Hyperplasia, Cystic, Glandular     66 (94%)     49 (94%)     50 (93%)     66 (96%)                               
      Endometrium, Thrombosis                                                    1 (2%)                                             
      Lymphatic, Cyst                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (50)         (69)                                   
      Femoral, Atrophy                                 1 (1%)                                 1 (1%)                                
   Lymph Node                                         (70)         (50)         (49)         (68)                                   
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                             1 (2%)                                             
   Lymph Node, Mandibular                             (67)         (50)         (47)         (62)                                   
      Depletion Lymphoid                                                         1 (2%)                                             
      Infiltration Cellular, Histiocyte                             2 (4%)                                                          
   Lymph Node, Mesenteric                             (64)         (48)         (44)         (59)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
   Spleen                                             (70)         (50)         (50)         (69)                                   
      Depletion Lymphoid                               1 (1%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (3%)       3 (6%)       4 (8%)       2 (3%)                                
      Inflammation, Chronic Active                                                            1 (1%)                                
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                              1 (1%)                                
   Thymus                                             (66)         (49)         (47)         (63)                                   
      Depletion Lymphoid                               3 (5%)       3 (6%)       3 (6%)       3 (5%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (62)         (45)         (39)         (53)                                   
      Hyperplasia, Cystic                                           1 (2%)       1 (3%)                                             
   Skin                                               (70)         (50)         (50)         (69)                                   
      Abscess                                                       1 (2%)                                                          
      Acanthosis                                                    1 (2%)                                                          
      Alopecia                                         4 (6%)       2 (4%)       3 (6%)       3 (4%)                                
      Ulcer                                                         4 (8%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    4 (8%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Back, Inflammation, Chronic Active               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Compression                                                                             1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydrocephalus                                                 1 (2%)                    1 (2%)                                
      Cerebellum, Cyst Epithelial Inclusion                                      1 (2%)                                             
   Spinal Cord                                        (2)                                                                           
      Lumbar, Degeneration                             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (50)         (69)                                   
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                              1 (2%)       2 (4%)       1 (1%)                                
      Perivascular, Inflammation, Chronic Active       1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (1)                                    
      Cornea, Inflammation, Chronic Active                                                    1 (100%)                              
   Harderian Gland                                    (6)          (3)          (2)                                                 
      Hyperplasia                                      3 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (50)         (50)         (69)                                   
      Nephropathy                                     41 (59%)     36 (72%)     33 (66%)     31 (45%)                               
      Pelvis, Inflammation, Chronic Active                                                    1 (1%)                                
      Renal Tubule, Cytomegaly                                                                1 (1%)                                
      Renal Tubule, Regeneration                                                              1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           19           19                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            2            1                                     
    Natural Death                                      2            3            3            3                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           43           46           46                                     
    Moribund Sacrifice                                 1            1                                                               
  Animals Examined Microscopically                    70           60           61           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (62)         (47)         (50)         (68)                                   
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Intestine Small, Jejunum                           (69)         (49)         (50)         (69)                                   
      Diverticulum                                                                            1 (1%)                                
   Liver                                              (70)         (59)         (60)         (69)                                   
      Basophilic Focus                                 1 (1%)                    4 (7%)                                             
      Clear Cell Focus                                 2 (3%)      11 (19%)      6 (10%)      1 (1%)                                
      Eosinophilic Focus                               1 (1%)       6 (10%)      3 (5%)       1 (1%)                                
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Hypertrophy                                      1 (1%)                                                                       
      Infarct                                          3 (4%)       2 (3%)       2 (3%)       2 (3%)                                
      Inflammation, Chronic Active                                  1 (2%)                    1 (1%)                                
      Mineralization, Focal                                                                   1 (1%)                                
      Mixed Cell Focus                                                                        1 (1%)                                
      Necrosis                                         2 (3%)                                                                       
      Vacuolization Cytoplasmic                       27 (39%)     21 (36%)     23 (38%)     24 (35%)                               
      Bile Duct, Hyperplasia                           1 (1%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic         7 (10%)                                3 (4%)                                
   Mesentery                                          (2)                       (1)                                                 
      Fat, Inflammation, Chronic Active                2 (100%)                                                                     
   Pancreas                                           (70)         (49)         (50)         (69)                                   
      Acinus, Atrophy                                  2 (3%)       2 (4%)                    3 (4%)                                
      Duct, Cyst                                       2 (3%)                                                                       
   Stomach, Forestomach                               (70)         (49)         (51)         (69)                                   
      Erosion, Focal                                                                          2 (3%)                                
      Hyperplasia, Focal, Squamous                     2 (3%)       1 (2%)       5 (10%)     14 (20%)                               
      Inflammation, Chronic Active                                                            5 (7%)                                
      Ulcer                                                                                   6 (9%)                                
   Stomach, Glandular                                 (69)         (49)         (51)         (68)                                   
      Dysplasia                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                                   1 (2%)                                                          
   Tooth                                                                        (1)                                                 
      Incisor, Abscess                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (49)         (51)         (68)                                   
      Spindle Cell, Accessory Adrenal Cortical                                                                                      
          Nodule                                                                 1 (2%)                                             
      Spindle Cell, Vacuolization Cytoplasmic          1 (1%)                                                                       
   Adrenal Gland, Cortex                              (69)         (49)         (51)         (68)                                   
      Accessory Adrenal Cortical Nodule                1 (1%)                                                                       
      Atrophy                                          1 (1%)                                                                       
      Hyperplasia                                      3 (4%)       3 (6%)       5 (10%)      1 (1%)                                
      Hypertrophy                                     27 (39%)     37 (76%)     35 (69%)     26 (38%)                               
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Adrenal Gland, Medulla                             (69)         (47)         (48)         (67)                                   
      Cyst                                                                                    1 (1%)                                
      Hyperplasia                                      1 (1%)                                                                       
   Islets, Pancreatic                                 (70)         (49)         (50)         (69)                                   
      Hyperplasia                                      3 (4%)       5 (10%)      2 (4%)       3 (4%)                                
   Parathyroid Gland                                  (65)         (48)         (46)         (65)                                   
      Cyst                                                          2 (4%)                                                          
   Pituitary Gland                                    (62)         (44)         (49)         (64)                                   
      Pars Distalis, Cyst                              2 (3%)       1 (2%)                    2 (3%)                                
      Pars Distalis, Hyperplasia                                                              1 (2%)                                
      Pars Distalis, Karyomegaly                                                              1 (2%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Intermedia, Hyperplasia, Focal                                        1 (2%)                                             
      Rathke's Cleft, Cyst                                                       1 (2%)                                             
   Thyroid Gland                                      (70)         (51)         (52)         (69)                                   
      Inflammation, Chronic Active                                               2 (4%)       1 (1%)                                
      Follicle, Cyst                                   1 (1%)       7 (14%)      7 (13%)      5 (7%)                                
      Follicle, Dilatation                             2 (3%)       2 (4%)       5 (10%)     38 (55%)                               
      Follicular Cell, Hyperplasia, Focal              5 (7%)       2 (4%)       8 (15%)     27 (39%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (33)         (26)         (20)         (31)                                   
      Inflammation, Chronic Active                     5 (15%)                   2 (10%)      1 (3%)                                
      Duct, Dilatation                                29 (88%)     25 (96%)     18 (90%)     30 (97%)                               
   Seminal Vesicle                                    (60)         (49)         (51)         (61)                                   
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Testes                                             (70)         (49)         (52)         (69)                                   
      Granuloma Sperm                                                            1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
      Seminiferous Tubule, Atrophy                     1 (1%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (65)         (43)         (50)         (65)                                   
      Depletion Lymphoid                               1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (46)         (45)         (63)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       7 (15%)      2 (4%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
   Spleen                                             (69)         (49)         (50)         (69)                                   
      Depletion Lymphoid                               1 (1%)                                                                       
      Hematopoietic Cell Proliferation                              4 (8%)       1 (2%)       2 (3%)                                
      Necrosis                                         1 (1%)                                                                       
   Thymus                                             (55)         (42)         (47)         (59)                                   
      Depletion Lymphoid                               4 (7%)       5 (12%)      4 (9%)       5 (8%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (70)         (49)         (51)         (68)                                   
      Alopecia                                         1 (1%)       2 (4%)       1 (2%)       3 (4%)                                
      Ulcer                                            1 (1%)       3 (6%)       3 (6%)       1 (1%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (1%)       1 (2%)       3 (6%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (1)                                                                           
      Sciatic, Demyelination                           1 (100%)                                                                     
   Spinal Cord                                        (1)                                                                           
      Demyelination                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (49)         (51)         (69)                                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                                           4 (8%)       1 (1%)                                
   Nose                                               (70)         (49)         (51)         (69)                                   
      Mucosa, Inflammation, Acute                      1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
   Harderian Gland                                    (6)          (4)          (3)          (5)                                    
      Hyperplasia                                                   1 (25%)      1 (33%)                                            
      Acinus, Dilatation                                            1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (49)         (51)         (69)                                   
      Hydronephrosis                                   1 (1%)       1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (1%)                                
      Nephropathy                                     47 (67%)     48 (98%)     46 (90%)     47 (68%)                               
      Cortex, Cyst                                                  3 (6%)                                                          
      Renal Tubule, Regeneration                      10 (14%)                                6 (9%)                                
   Urinary Bladder                                    (68)         (49)         (51)         (68)                                   
      Lumen, Hemorrhage                                                                       1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.