National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3564

TDMS Study 05085-02 Pathology Tables

NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97
Route: DOSED FEED                                                                                                 Time: 17:42:42




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 4| 2| 7| 3| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 5| 5| 5| 2| 2| 2| 0| 2| 5| 2| 2| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 9|             
                                           | 9| 9| 9| 2| 2| 3| 9| 9| 9| 8| 0| 3| 9| 9| 0| 7| 0| 0| 0| 3| 6| 0| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                                                                        |             
      Cytomegaly, Multifocal               |                                           2                              |             
      Eosinophilic Focus                   |    X                                                  X        X         |             
      Inflammation, Chronic                |                                                                          |             
      Vacuolization Cytoplasmic            |    3                                                     2              2|             
      Hepatocyte, Atrophy                  |                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +                       +                     |             
      Fat, Inflammation, Chronic Active    |    3                       3                       2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                     2                                1   |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 4| 2| 7| 3| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 5| 5| 5| 2| 2| 2| 0| 2| 5| 2| 2| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 9|             
                                           | 9| 9| 9| 2| 2| 3| 9| 9| 9| 8| 0| 3| 9| 9| 0| 7| 0| 0| 0| 3| 6| 0| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         X                          X                     |             
      Pars Distalis, Hyperplasia           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |       X        X                    X           X                 X      |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Diffuse|                                        1                                 |             
      Follicular Cell, Hyperplasia, Focal  |    4              1                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                               3                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Follicle, Cyst            |                                                                          |             
      Follicle, Cyst                       |       X              X              X           X                    X   |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 3  3  4  3  3  2  3  4  3     4  2  4  3  3  3  3     3  2  2  3  2  4  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 4| 2| 7| 3| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 5| 5| 5| 2| 2| 2| 0| 2| 5| 2| 2| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 9|             
                                           | 9| 9| 9| 2| 2| 3| 9| 9| 9| 8| 0| 3| 9| 9| 0| 7| 0| 0| 0| 3| 6| 0| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Alopecia                             | X                                               X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Back, Inflammation, Chronic Active   |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +     +|             
      Lumbar, Degeneration                 |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  1           1  1  2     2     2  2  1     1  1  1        2     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 4| 7| 4| 2| 7| 7| 7| 2| 7| 6| 7| 2| 2|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 5| 3| 5| 7| 3| 2| 3| 7| 3| 0| 3| 7| 7|             
                                           | 0| 7| 0| 1| 1| 1| 1| 1| 1| 1| 3| 7| 2| 1| 3| 6| 2| 0| 2| 6| 2| 7| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0PPM                                   | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cytomegaly, Multifocal               |                                                                          |             
      Eosinophilic Focus                   |                   X                                         X            |             
      Inflammation, Chronic                |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                   2      |             
      Hepatocyte, Atrophy                  |                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                       +                     |             
      Fat, Inflammation, Chronic Active    |       3                    4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                            2                                             |             
      Ulcer                                |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                   2      |             
      Inflammation, Chronic                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                  2      |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                         3                                         2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 4| 7| 4| 2| 7| 7| 7| 2| 7| 6| 7| 2| 2|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 5| 3| 5| 7| 3| 2| 3| 7| 3| 0| 3| 7| 7|             
                                           | 0| 7| 0| 1| 1| 1| 1| 1| 1| 1| 3| 7| 2| 1| 3| 6| 2| 0| 2| 6| 2| 7| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0PPM                                   | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          2                             2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |       X                    X                          X        X         |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                            4                                             |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Follicle, Cyst            |                                                                          |             
      Follicle, Cyst                       | X                       X  X           X        X     X                  |             
      Periovarian Tissue, Cyst             |                                                             X           X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 4  2  4  4  3  2  4  3  4  3  2  3     4  3  2  4  3  3  2  3  2  4  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 4| 7| 4| 2| 7| 7| 7| 2| 7| 6| 7| 2| 2|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 5| 3| 5| 7| 3| 2| 3| 7| 3| 0| 3| 7| 7|             
                                           | 0| 7| 0| 1| 1| 1| 1| 1| 1| 1| 3| 7| 2| 1| 3| 6| 2| 0| 2| 6| 2| 7| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0PPM                                   | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Alopecia                             |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Back, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Lumbar, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       1                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Hyperplasia                          |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1     1  1  1  1  2  2  1  4           1        1     1        1  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 2| 7| 2| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7|              |            |
                                           | 2| 2| 6| 7| 2| 6| 2| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basophilic Focus                     |                                                                          |      1     |
      Cytomegaly, Multifocal               |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                            X     X              X                        |      8     |
      Inflammation, Chronic                |                                                       3                  |      1  3.0|
      Vacuolization Cytoplasmic            |                         3              1                                 |      6  2.2|
      Hepatocyte, Atrophy                  |                                                       2                  |      1  2.0|
      Kupffer Cell, Hyperplasia            |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +              +                                                |   8        |
      Fat, Inflammation, Chronic Active    |                         3                                                |      6  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acinus, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  2.0|
      Ulcer                                |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Degeneration                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 2| 7| 2| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7|              |            |
                                           | 2| 2| 6| 7| 2| 6| 2| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                  2                    2                  |      4  2.0|
      Hypertrophy                          |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  66        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Pars Distalis, Cyst                  |                   X                                                      |      3     |
      Pars Distalis, Hyperplasia           |                         1     2        2                                 |      6  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
      Follicle, Cyst                       | X     X     X  X           X     X  X        X  X                        |     18     |
      Follicle, Dilatation                 | 1                                                                        |      1  1.0|
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia, Focal  | 2                                                                        |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Atrophy                              |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Bilateral, Atrophy                   |                         3                                                |      1  3.0|
      Bilateral, Follicle, Cyst            |                                     X                                    |      1     |
      Follicle, Cyst                       | X     X     X     X        X     X           X  X                        |     19     |
      Periovarian Tissue, Cyst             |                               X                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 4  4  3  3  3  1  4  3     3  4  4  3  4  4  2  4  4  3  2               |     66  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Femoral, Atrophy                     |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 2| 7| 2| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7|              |            |
                                           | 2| 2| 6| 7| 2| 6| 2| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +                  |  64        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Depletion Lymphoid                   |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  66        |
      Depletion Lymphoid                   |    2                                                                     |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +               |  62        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Alopecia                             |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Back, Inflammation, Chronic Active   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Lumbar, Degeneration                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |       2                                                                  |      2  1.5|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                    +  +     +        +                     |   6        |
      Hyperplasia                          |             2                                      2                     |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Nephropathy                          |    2              2     3  2  1  2  1  1  1     1  1  1                  |     41  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 6| 2| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 5| 3| 7| 7| 7| 3| 3| 5| 3| 3| 5| 3| 2| 3|             
                                           | 3| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 2| 0| 6| 9| 6| 0| 0| 3| 0| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X                       X                                    |             
      Clear Cell Focus                     |       X                             X                                   X|             
      Eosinophilic Focus                   |             X  X  X                             X  X                     |             
      Infarct                              |                                                                          |             
      Inflammation, Acute, Focal           |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Vacuolization Cytoplasmic            |                            2                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Fat, Inflammation, Chronic Active    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Acinus, Atrophy                      |    3                                                                    2|             
      Duct, Cyst                           |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Hyperplasia, Focal, Squamous         |                   2                                                      |             
      Inflammation, Chronic Active         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Hypertrophy                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Pars Distalis, Cyst                  |                X                                   X        X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 6| 2| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 5| 3| 7| 7| 7| 3| 3| 5| 3| 3| 5| 3| 2| 3|             
                                           | 3| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 2| 0| 6| 9| 6| 0| 0| 3| 0| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                2           2  3                             3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Inflammation, Chronic Active         |    1                                                                     |             
      Follicle, Cyst                       |    X              X                                      X           X   |             
      Follicle, Dilatation                 |                1                                            1            |             
      Follicular Cell, Hyperplasia, Diffuse|                                           1                              |             
      Follicular Cell, Hyperplasia, Focal  |                2                          4                          1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Mineralization                       |                                                                          |             
      Follicle, Cyst                       |                X  X     X                                X              X|             
      Periovarian Tissue, Cyst             |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +  +  +  +  +  +  +     +     +     +  +  +  +  +     +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |    4  3     3  4  3  4  3  2  3     3           3  3  3  3  2     3  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +  +  +  +     +     M     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                           3                          3   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Depletion Lymphoid                   |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +  +  +  M  +  +  +     +     M     +  +     +  M     +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |                                                                          |             
      Alopecia                             |                                                                          |             
      Ulcer                                |                                           4                          3   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                           3                          3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 6| 2| 7| 7| 4| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 5| 3| 7| 7| 7| 3| 3| 5| 3| 3| 5| 3| 2| 3|             
                                           | 3| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 2| 0| 6| 9| 6| 0| 0| 3| 0| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                             +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
      Nephropathy                          |    2        1  1  2        2  1     1     1     1  1        1     1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 7| 7| 2| 4| 7| 7| 2| 7| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 3| 7| 3| 3| 3| 5| 3| 5| 3| 3| 7| 5| 3| 1| 7| 3| 3| 7| 3| 3| 3|             
                                           | 2| 0| 0| 7| 1| 7| 1| 1| 1| 2| 1| 3| 1| 1| 6| 3| 1| 2| 6| 1| 2| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    1500 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +     +  M  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +|             
      Basophilic Focus                     |                               X                          X               |             
      Clear Cell Focus                     |                                                             X            |             
      Eosinophilic Focus                   |                                                          X               |             
      Infarct                              |                                     2                                    |             
      Inflammation, Acute, Focal           |                                              2                           |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Acinus, Atrophy                      |    2                                                                     |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                    2                 1   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                             2        2   |             
      Hypertrophy                          |       2                             2                    2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +     +  +  +     +     +  +        +  +     +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  +     M     M  +  +     +     +  +        +  +     +  +     +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 7| 7| 2| 4| 7| 7| 2| 7| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 3| 7| 3| 3| 3| 5| 3| 5| 3| 3| 7| 5| 3| 1| 7| 3| 3| 7| 3| 3| 3|             
                                           | 2| 0| 0| 7| 1| 7| 1| 1| 1| 2| 1| 3| 1| 1| 6| 3| 1| 2| 6| 1| 2| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    1500 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                         3                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Inflammation, Chronic Active         |       1                                                                  |             
      Follicle, Cyst                       |    X  X                                            X        X     X     X|             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |       1     2     1     2     1        1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Mineralization                       |                                                                          |             
      Follicle, Cyst                       |    X  X                 X     X     X                    X  X            |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 3  3  3     3     3  3  4     3     3  3        3  3     4  3     3  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +     +  +  +     +     +  M        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  M|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +     +  M  +     +     +  +        +  +     +  +     +  +  +|             
      Hyperplasia, Cystic                  |                                                    4                     |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Abscess                              |                                                    4                     |             
      Acanthosis                           |       3                                                                  |             
      Alopecia                             |                   X                                      X               |             
      Ulcer                                |                                                    4                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 7| 7| 2| 4| 7| 7| 2| 7| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 3| 7| 3| 3| 3| 5| 3| 5| 3| 3| 7| 5| 3| 1| 7| 3| 3| 7| 3| 3| 3|             
                                           | 2| 0| 0| 7| 1| 7| 1| 1| 1| 2| 1| 3| 1| 1| 6| 3| 1| 2| 6| 1| 2| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    1500 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Hydrocephalus                        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
      Nephropathy                          |             2     2  1  1     1     1  1        1  1     1           1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +     +  +  +     +     +  +        +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 2| 7|              |            |
                             DAY ON TEST   | 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 7| 3|              |            |
                                           | 2| 1| 2| 2| 3| 2| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 7| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +               |  60        |
      Basophilic Focus                     |                                     X        X                           |      7     |
      Clear Cell Focus                     |                X                                                         |      5     |
      Eosinophilic Focus                   |          X                                X                              |      8     |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |             2              3                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                              |   3        |
      Fat, Inflammation, Chronic Active    |                                           2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Acinus, Atrophy                      |                      4                                                   |      4  2.8|
      Duct, Cyst                           |                      X                                                   |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Hyperplasia, Focal, Squamous         |                                                                          |      3  1.7|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Hyperplasia                          | 2                 1                       2        2                     |      7  1.9|
      Hypertrophy                          |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 2| 7|              |            |
                             DAY ON TEST   | 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 7| 3|              |            |
                                           | 2| 1| 2| 2| 3| 2| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 7| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  M  +  +     +  +  +  +     +     +               |  46        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia           |                      2                       2                           |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Follicle, Cyst                       |          X              X                                                |     12     |
      Follicle, Dilatation                 |                      1        1                    1                     |      5  1.0|
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia, Focal  |                         1     1     1              2     1               |     15  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +               |  51        |
      Mineralization                       |                            2                                             |      1  2.0|
      Follicle, Cyst                       |    X  X           X           X     X                 X  X               |     19     |
      Periovarian Tissue, Cyst             | X                                                                        |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  52        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |    2  4  3     3  3  3  3  3  3     3  3  3  3     4     3               |     49  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  49        |
      Depletion Lymphoid                   | 2  3                                                                     |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +     +  +  M  +     +     +               |  45        |
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 2| 7|              |            |
                             DAY ON TEST   | 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 7| 3|              |            |
                                           | 2| 1| 2| 2| 3| 2| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 7| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Acanthosis                           |                                                                          |      1  3.0|
      Alopecia                             |                                                                          |      2     |
      Ulcer                                |    4                                                                     |      4  3.8|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |    3                                                                     |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
      Nephropathy                          |    1              1  1  1     1     1  1  1  2     1     1               |     36  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +     +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 2| 7| 7| 4| 6| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 7| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 7| 2| 2| 5| 9| 2| 2| 2| 5| 5| 5| 5| 9| 3| 0| 2| 0| 3| 3| 7| 3|             
                                           | 7| 9| 9| 9| 6| 9| 9| 2| 3| 9| 3| 9| 2| 2| 3| 3| 6| 0| 9| 5| 2| 0| 0| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X                                                                     |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Infarct                              |       2                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Vacuolization Cytoplasmic            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Inflammation, Chronic Active    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +     +  +  +  +           +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +     +  +  +  +           +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Focal, Squamous         |                                              2  2                        |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Mineralization                       |                                                 3                        |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Hyperplasia                          |    2           1                                                         |             
      Hypertrophy                          |          3                                                               |             
      Mineralization                       |                                                 2                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 2| 7| 7| 4| 6| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 7| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 7| 2| 2| 5| 9| 2| 2| 2| 5| 5| 5| 5| 9| 3| 0| 2| 0| 3| 3| 7| 3|             
                                           | 7| 9| 9| 9| 6| 9| 9| 2| 3| 9| 3| 9| 2| 2| 3| 3| 6| 0| 9| 5| 2| 0| 0| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +     +  +     +  +  +  +              M  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +     +  +  +  +  +  +  +              +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                                  1                                       |             
      Follicle, Cyst                       |                      X  X  X                                             |             
      Follicle, Dilatation                 |                         1     1                          1     2         |             
      Follicular Cell, Hyperplasia, Focal  |    1     2        1     1  3  1                    1           3  2     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +           +  +  +  +  +  +  +     +|             
      Thrombosis                           |                                                 X                        |             
      Follicle, Cyst                       |    X     X  X        X              X              X           X  X      |             
      Periovarian Tissue, Cyst             |                                                                X         |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +     +  +  +  +  +  +        +  +  +  +  +  +  +     +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |    4  3  3     3  3     2  3  3  3  3  3        4  3  3  3  2  4  4     3|             
      Endometrium, Thrombosis              |                                                                         X|             
      Lymphatic, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +     +  +     +  +     +              +  +  +  +  +  +  +     +|             
      Depletion Lymphoid                   |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +     +  +     M  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 4     3                 3|             
      Necrosis                             |                                                          4               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +     M  +  +  +              +  +  M  +  +  +  +     +|             
      Depletion Lymphoid                   |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 2| 7| 7| 4| 6| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 7| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 7| 2| 2| 5| 9| 2| 2| 2| 5| 5| 5| 5| 9| 3| 0| 2| 0| 3| 3| 7| 3|             
                                           | 7| 9| 9| 9| 6| 9| 9| 2| 3| 9| 3| 9| 2| 2| 3| 3| 6| 0| 9| 5| 2| 0| 0| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  M     M|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Alopecia                             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Cerebellum, Cyst Epithelial Inclusion|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Alveolar Epithelium, Hyperplasia     |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +     +  +  +  +              +  +  +  +  +  +  +     +|             
      Nephropathy                          |    1  1  1     1  1     1  1  4  1              4  1     2  1     2     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +  +     +  +  +  +              +  +  M  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 2| 0| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 1| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 6| 7| 9| 1| 7| 6| 1| 1| 1| 1| 1| 1| 1| 2| 3| 7| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    5000 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +           +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |                                                 X                        |             
      Clear Cell Focus                     |                                     X                                    |             
      Eosinophilic Focus                   |                                                             X            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Vacuolization Cytoplasmic            |                                  3     1        1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Acinus, Atrophy                      |                               2                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                        2                                 |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +           +  +     +     +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia                          | 2                             1     2                             1      |             
      Hypertrophy                          |                                                 2           2            |             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic            | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 2| 0| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 1| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 6| 7| 9| 1| 7| 6| 1| 1| 1| 1| 1| 1| 1| 2| 3| 7| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    5000 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +           +  +     +     +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +           +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                   X      |             
      Pars Distalis, Hyperplasia           |          2           2                             1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +           +  +     +  +  +  +  M  +  +  +     +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation, Chronic Active         |                                  1                                       |             
      Inflammation, Granulomatous          |                                                                          |             
      Follicle, Cyst                       | X                             X                                          |             
      Follicle, Dilatation                 |          3           2                                   1               |             
      Follicular Cell, Hyperplasia, Focal  |    1     1           3  1     2  3     1     1     1        1  1     1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Follicle, Cyst                       |                      X              X     X  X     X              X      |             
      Periovarian Tissue, Cyst             |                                                             X           X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 4  3  3  3           4  3     4  3  3  3  2  3  3  4  3     4  3  4  3  4|             
      Endometrium, Thrombosis              |                                                                          |             
      Lymphatic, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +     +  +|             
      Depletion Lymphoid                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 2| 0| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 1| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 6| 7| 9| 1| 7| 6| 1| 1| 1| 1| 1| 1| 1| 2| 3| 7| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    5000 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +           M  +     M  +  +  +  +     +  +        +  M  +  +  +|             
      Hyperplasia, Cystic                  |                                           3                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Alopecia                             |          X                                   X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cerebellum, Cyst Epithelial Inclusion|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +              +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Nephropathy                          | 1     1                 1     1  1  1        1  1  1        2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +           +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 1| 4| 5| 7| 7| 7| 7| 7| 4| 7| 7| 2| 2| 7| 4| 4|              |            |
                             DAY ON TEST   | 1| 3| 7| 3| 0| 5| 5| 3| 0| 3| 3| 3| 5| 3| 3| 7| 7| 3| 5| 8|              |            |
                                           | 0| 2| 7| 2| 7| 3| 4| 3| 4| 3| 3| 3| 3| 3| 3| 7| 7| 3| 2| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +     +  +     +  +  +  +  +  +     +  +        +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +               |  59        |
      Basophilic Focus                     |                      X              X                                    |      3     |
      Clear Cell Focus                     |                                                    X                     |      2     |
      Eosinophilic Focus                   |                            X                                             |      3     |
      Hepatodiaphragmatic Nodule           |                                  X                                       |      2     |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |          3                 1                             2               |      7  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Inflammation, Chronic Active    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Acinus, Atrophy                      |                                                          3               |      2  2.5|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +     +  +     +  +  +     +  +        +     +               |  50        |
      Hyperplasia, Focal, Squamous         |                                  2                                       |      4  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  51        |
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                   2     3                                                |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Corticomedullary Junction,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 1| 4| 5| 7| 7| 7| 7| 7| 4| 7| 7| 2| 2| 7| 4| 4|              |            |
                             DAY ON TEST   | 1| 3| 7| 3| 0| 5| 5| 3| 0| 3| 3| 3| 5| 3| 3| 7| 7| 3| 5| 8|              |            |
                                           | 0| 2| 7| 2| 7| 3| 4| 3| 4| 3| 3| 3| 3| 3| 3| 7| 7| 3| 2| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +     +  +  +  +     +     +  +        +     +               |  48        |
      Hyperplasia                          |                                                                          |      6  1.5|
      Hypertrophy                          |          2                 1                       2                     |      6  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +     +  +  +  +     +     +  +        +     +               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +     +  +        +     +               |  52        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                            2  1                                          |      3  1.3|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Follicle, Cyst                       |                X        X  X           X                                 |      9     |
      Follicle, Dilatation                 | 1        1                    1           1        1                     |     12  1.3|
      Follicular Cell, Hyperplasia, Focal  |          1           1                    3        1                     |     27  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  53        |
      Thrombosis                           |                                                                          |      1     |
      Follicle, Cyst                       |                   X           X        X  X                              |     18     |
      Periovarian Tissue, Cyst             |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +     +  +        +     +               |  54        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |    2           3     4  2  3  3  4     3  4        4     2               |     50  3.2|
      Endometrium, Thrombosis              |                                                                          |      1     |
      Lymphatic, Cyst                      |                                                    X                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +     +  +  +  +  +  +     M  +        +     +               |  49        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +     +  +  +  +  +  +     M  +        +     +               |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 1| 4| 5| 7| 7| 7| 7| 7| 4| 7| 7| 2| 2| 7| 4| 4|              |            |
                             DAY ON TEST   | 1| 3| 7| 3| 0| 5| 5| 3| 0| 3| 3| 3| 5| 3| 3| 7| 7| 3| 5| 8|              |            |
                                           | 0| 2| 7| 2| 7| 3| 4| 3| 4| 3| 3| 3| 3| 3| 3| 7| 7| 3| 2| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +     +     +  +  M        M  +        +     +               |  44        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Depletion Lymphoid                   |             3                                                            |      1  3.0|
      Hematopoietic Cell Proliferation     |                   4                                                      |      4  3.5|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     +  +     +  +  +  +  +  +     +  +        +     +               |  47        |
      Depletion Lymphoid                   |             2     2                                                      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     +  M     +  M  +  +  M  +     +  +        +     +               |  39        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Alopecia                             |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Cerebellum, Cyst Epithelial Inclusion|          X                                                               |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  50        |
      Nephropathy                          |          1                             1  1        1                     |     33  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +     +  +  +  +  +  +     +  +        +     +               |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 7| 2| 7| 4| 2| 2| 4| 7| 4| 7| 7| 2| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 4| 2| 2| 2| 7| 2| 3| 7| 3| 5| 7| 7| 8| 3| 5| 3| 3| 7| 5| 5|             
                                           | 9| 9| 9| 9| 9| 7| 9| 9| 9| 7| 9| 0| 7| 0| 2| 7| 7| 8| 0| 3| 0| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                                                |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |    X                                                        X        X   |             
      Inflammation, Chronic Active         |             2                                                            |             
      Mixed Cell Focus                     |                               X        X                                 |             
      Vacuolization Cytoplasmic            |                   1                                4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             4                                                            |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |          4                                            4                  |             
      Hyperplasia, Focal, Squamous         |          2                 2  1                       3                  |             
      Inflammation, Chronic Active         |          3                                                               |             
      Ulcer                                |          3                                            2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
      Hypertrophy                          |       2  1                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       1  3           3           2     2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 7| 2| 7| 4| 2| 2| 4| 7| 4| 7| 7| 2| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 4| 2| 2| 2| 7| 2| 3| 7| 3| 5| 7| 7| 8| 3| 5| 3| 3| 7| 5| 5|             
                                           | 9| 9| 9| 9| 9| 7| 9| 9| 9| 7| 9| 0| 7| 0| 2| 7| 7| 8| 0| 3| 0| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                               X  X                                       |             
      Follicle, Dilatation                 |    1     1        2           1  1        1  1  1  1  1        1        1|             
      Follicular Cell, Hyperplasia, Focal  | 1  1  4  1  2     2  4        1  1     3              2        2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Bilateral, Follicle, Cyst            |                                                                          |             
      Follicle, Cyst                       |                   X                                            X        X|             
      Periovarian Tissue, Cyst             | X                       X     X  X        X                              |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |             4                                                            |             
      Rete Ovarii, Cyst                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Inflammation, Chronic Active |                                                                          |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 4  4  4  4  4  2  4  3  3  3  3  3  2  3  3  3  3  3  4  3  3  3  3  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  M  +  M|             
      Inflammation, Chronic Active         |             4                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
      Inflammation, Chronic Active         |             4                                                            |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Chronic Active         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                X         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 7| 2| 7| 4| 2| 2| 4| 7| 4| 7| 7| 2| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 4| 2| 2| 2| 7| 2| 3| 7| 3| 5| 7| 7| 8| 3| 5| 3| 3| 7| 5| 5|             
                                           | 9| 9| 9| 9| 9| 7| 9| 9| 9| 7| 9| 0| 7| 0| 2| 7| 7| 8| 0| 3| 0| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             3                                                            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1  1     2  1  1     1        1           2           1         |             
      Pelvis, Inflammation, Chronic Active |             3                                                            |             
      Renal Tubule, Cytomegaly             |                2                                                         |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 2| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 5| 7| 3| 3| 7| 3| 3| 5| 5| 3| 7| 3| 3| 3| 3| 5| 3|             
                                           | 0| 6| 0| 0| 1| 1| 1| 1| 2| 6| 1| 1| 7| 1| 1| 3| 2| 1| 6| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     15000                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X                             X         |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                X                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                                                    X                     |             
      Vacuolization Cytoplasmic            |                1                          1                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Hyperplasia, Focal, Squamous         | 3                       2        3     3  2              3               |             
      Inflammation, Chronic Active         |                         1              1                                 |             
      Ulcer                                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1     2              2                                          |             
      Hypertrophy                          | 2              2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 2| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 5| 7| 3| 3| 7| 3| 3| 5| 5| 3| 7| 3| 3| 3| 3| 5| 3|             
                                           | 0| 6| 0| 0| 1| 1| 1| 1| 2| 6| 1| 1| 7| 1| 1| 3| 2| 1| 6| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     15000                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |             X  X                                               X         |             
      Follicle, Dilatation                 | 2  1  1        1        1  1  2     1  1     1        1  1  1  1     1   |             
      Follicular Cell, Hyperplasia, Focal  | 1     1     4  1  1  2        2  2     1  2              2  1  4  4     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   4                                                      |             
      Bilateral, Follicle, Cyst            |                                        X                                 |             
      Follicle, Cyst                       |       X           X                                            X  X      |             
      Periovarian Tissue, Cyst             | X                                               X                        |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
      Rete Ovarii, Cyst                    |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Inflammation, Chronic Active |                                                                          |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 4  3  3  4  4  3  3  3     2  3  3  3  3  4  3  3  3  3  4  3  3  4  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +     +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             | X                                                                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 2| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 5| 7| 3| 3| 7| 3| 3| 5| 5| 3| 7| 3| 3| 3| 3| 5| 3|             
                                           | 0| 6| 0| 0| 1| 1| 1| 1| 2| 6| 1| 1| 7| 1| 1| 3| 2| 1| 6| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     15000                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Cornea, Inflammation, Chronic Active |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1        1  1                    1     1  1        1     1  2  1  1     1|             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Renal Tubule, Cytomegaly             |                                                                          |             
      Renal Tubule, Regeneration           |                                                                      1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 2| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 5| 3| 8| 3| 0| 3| 9| 3| 3| 3| 2| 3| 7|              |            |
                                           | 2| 2| 2| 3| 6| 7| 3| 2| 3| 9| 3| 9| 3| 6| 3| 3| 3| 6| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Basophilic Focus                     |                                           X           X                  |      5     |
      Congestion                           |                                              2                           |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      4     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Vacuolization Cytoplasmic            |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Erosion, Focal                       |                                                                          |      2  4.0|
      Hyperplasia, Focal, Squamous         |                                           2                              |     11  2.4|
      Inflammation, Chronic Active         |                                           1                              |      4  1.5|
      Ulcer                                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperplasia                          |                   2                                                      |      5  1.8|
      Hypertrophy                          |       1                                                                  |      5  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 2| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 5| 3| 8| 3| 0| 3| 9| 3| 3| 3| 2| 3| 7|              |            |
                                           | 2| 2| 2| 3| 6| 7| 3| 2| 3| 9| 3| 9| 3| 6| 3| 3| 3| 6| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Pars Distalis, Cyst                  |                         X                                                |      1     |
      Pars Distalis, Hyperplasia           |       1  2                          2           1                        |     10  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Follicle, Cyst                       |       X  X                                                               |      7     |
      Follicle, Dilatation                 |       1        1  1        1     2           1  1  1  1                  |     36  1.1|
      Follicular Cell, Hyperplasia, Focal  | 1  4  2  2  1     1     4  2  3  2  2  2  4  1  3     1                  |     43  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Fibrosis                             |                                                                          |      1  4.0|
      Bilateral, Follicle, Cyst            |                                                                          |      1     |
      Follicle, Cyst                       | X     X     X        X  X                       X  X                     |     14     |
      Periovarian Tissue, Cyst             |    X                             X                                       |      9     |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
      Rete Ovarii, Cyst                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Cervix, Inflammation, Chronic Active |                                     3                                    |      1  3.0|
      Endometrium, Angiectasis             |       3                                                                  |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 4  3     3  2     3  3     3  3  3  3  2  3  4  4  3  3  2               |     66  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Femoral, Atrophy                     |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +     +  +  +  M  +  +  +  +  +  +     +  +  +               |  62        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  M  +  +  +  M  +  +  +  +  +  +               |  59        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hematopoietic Cell Proliferation     |                            4                                             |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 2| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 5| 3| 8| 3| 0| 3| 9| 3| 3| 3| 2| 3| 7|              |            |
                                           | 2| 2| 2| 3| 6| 7| 3| 2| 3| 9| 3| 9| 3| 6| 3| 3| 3| 6| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M     +  +  +  +  +  +  +  +  M  +  +  +  +  M               |  63        |
      Depletion Lymphoid                   |                            3           3              2                  |      3  2.7|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +     +  +  +  +  +  +  +  +  M  M  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Alopecia                             |    X                                                                     |      3     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Compression                          |                                                          X               |      1     |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Hydrocephalus                        |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Nephropathy                          | 1  1  3           1           1                 1  2                     |     31  1.2|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Renal Tubule, Cytomegaly             |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 2| 7| 2| 2| 2| 5| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3|             
                                           | 3| 9| 9| 2| 9| 9| 9| 6| 9| 9| 9| 2| 2| 9| 0| 0| 0| 0| 0| 0| 9| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                                            |             
      Clear Cell Focus                     |                                                                      X   |             
      Eosinophilic Focus                   |                                                                          |             
      Hypertrophy                          |                                                                2         |             
      Infarct                              |                                                                         4|             
      Necrosis                             |                               2                                         2|             
      Vacuolization Cytoplasmic            | 3           3  1  1        1        3  2     2           2              2|             
      Bile Duct, Hyperplasia               |                         2                                                |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                   +                  |             
      Fat, Inflammation, Chronic Active    |                   2                                   3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    3              1                                                      |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                             X            |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 2| 7| 2| 2| 2| 5| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3|             
                                           | 3| 9| 9| 2| 9| 9| 9| 6| 9| 9| 9| 2| 2| 9| 0| 0| 0| 0| 0| 0| 9| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          | 2  2                    3  2  2        1     3  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                2  2                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |             X                                                            |             
      Follicle, Dilatation                 |                            1  1                                          |             
      Follicular Cell, Hyperplasia, Focal  |                               1                 1        1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +     +     +  +        +  +  +  +  +  +     +  +     +  +|             
      Inflammation, Chronic Active         |                                                                      4   |             
      Duct, Dilatation                     |    3           3     3     3  3        3  3  3  3  3  3     3  4        3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Necrosis                             |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Depletion Lymphoid                   |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M     M  M  M  M  M  M  M        M  M  M  M  M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 2| 7| 2| 2| 2| 5| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3|             
                                           | 3| 9| 9| 2| 9| 9| 9| 6| 9| 9| 9| 2| 2| 9| 0| 0| 0| 0| 0| 0| 9| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Demyelination               |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Demyelination                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +           +  +  +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    4                                                                     |             
      Nephropathy                          |    3  1     3  2  3     2  2  2        2  3  3  2  2  2  2     2     2  2|             
      Renal Tubule, Regeneration           | 2        1                       1  1                             2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 4| 2| 7| 7| 4| 7| 4| 2| 7| 7| 2| 7| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 5| 5| 7| 3| 3| 6| 3| 5| 7| 3| 3| 7| 3| 3| 3| 8| 7| 7|             
                                           | 1| 1| 1| 3| 1| 1| 1| 3| 2| 6| 1| 1| 6| 1| 3| 6| 2| 2| 7| 2| 2| 2| 7| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0PPM                                   | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | I  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                          X               |             
      Hypertrophy                          |                                                                          |             
      Infarct                              |                                                                4         |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    2  2  3           2  2     2           3        2        2     2      |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                            3                 3                       3  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                X                                         X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |    3        2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 4| 2| 7| 7| 4| 7| 4| 2| 7| 7| 2| 7| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 5| 5| 7| 3| 3| 6| 3| 5| 7| 3| 3| 7| 3| 3| 3| 8| 7| 7|             
                                           | 1| 1| 1| 3| 1| 1| 1| 3| 2| 6| 1| 1| 6| 1| 3| 6| 2| 2| 7| 2| 2| 2| 7| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0PPM                                   | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          | 2  2  2     2  2                                1        2  2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | X     X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +           +  +     +                    +            |             
      Inflammation, Chronic Active         |                                  4     3                    2            |             
      Duct, Dilatation                     | 4  3  3     3  2  4           4                             3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +  +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  M  +  +  +  M  M  M|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Depletion Lymphoid                   |    2                          2                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M  M  M        M  M  M  M  M     M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 4| 2| 7| 7| 4| 7| 4| 2| 7| 7| 2| 7| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 5| 5| 7| 3| 3| 6| 3| 5| 7| 3| 3| 7| 3| 3| 3| 8| 7| 7|             
                                           | 1| 1| 1| 3| 1| 1| 1| 3| 2| 6| 1| 1| 6| 1| 3| 6| 2| 2| 7| 2| 2| 2| 7| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0PPM                                   | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                   +      |             
      Sciatic, Demyelination               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
      Demyelination                        |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                       +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 2  2  1     2  1  2           2  1     1        2  2     2  2  3         |             
      Renal Tubule, Regeneration           |          1           1  2                 2                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|              |            |
                                           | 5| 6| 6| 2| 2| 2| 6| 7| 2| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  62        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                X                                                         |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hypertrophy                          |                                                                          |      1  2.0|
      Infarct                              |             4                                                            |      3  4.0|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |                               1  2  2        2  2  2  2                  |     27  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |    3  3              3                                                   |      7  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Inflammation, Chronic Active    |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acinus, Atrophy                      |                                                                          |      2  2.0|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia, Focal, Squamous         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Spindle Cell, Vacuolization          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|              |            |
                                           | 5| 6| 6| 2| 2| 2| 6| 7| 2| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  69        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Atrophy                              |                                                          2               |      1  2.0|
      Hyperplasia                          |                                                                          |      3  2.0|
      Hypertrophy                          |                         2     2     2     1  2  2     3  2               |     27  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  I  M  +  +  +  +  +  +  +  +  M  +  +  +  +               |  62        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Dilatation                 |                                                                          |      2  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                          1               |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +           +  +           +     +     +     +               |  33        |
      Inflammation, Chronic Active         |                                                    4                     |      5  3.4|
      Duct, Dilatation                     |          4  3           3  3           3     3           3               |     29  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +        +  +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Seminiferous Tubule, Atrophy         |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +     +  +  +  M  +     +  +  +  +  +  +  +  +  +               |  65        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  M  +  +  +     +  +  +  +  M  +  M  +  +               |  56        |
      Hematopoietic Cell Proliferation     |             3                                                            |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|              |            |
                                           | 5| 6| 6| 2| 2| 2| 6| 7| 2| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Depletion Lymphoid                   | 2                                                                        |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  M  M               |  55        |
      Depletion Lymphoid                   |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M               |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Alopecia                             |                                                                          |      1     |
      Ulcer                                |                                        3                                 |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Sciatic, Demyelination               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Demyelination                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hydronephrosis                       |                                                                          |      1  4.0|
      Nephropathy                          | 4        2  3  2        2  4  2  1  1  1  2  3  3     2  2               |     47  2.1|
      Renal Tubule, Regeneration           |                                                    2                     |     10  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|              |            |
                                           | 5| 6| 6| 2| 2| 2| 6| 7| 2| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    0PPM                                   | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +               |  68        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 7| 2| 2| 7| 7| 4| 4| 7| 4| 7| 2| 7| 5| 7| 7| 7| 2| 2|             
                             DAY ON TEST   | 2| 5| 2| 2| 7| 2| 2| 2| 7| 7| 2| 2| 5| 5| 2| 5| 3| 7| 3| 8| 3| 3| 3| 7| 7|             
                                           | 9| 2| 9| 9| 6| 9| 9| 9| 7| 7| 9| 9| 3| 3| 9| 3| 0| 7| 0| 0| 0| 0| 0| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +     +  +  +      |             
      Clear Cell Focus                     |                               X                 X                        |             
      Eosinophilic Focus                   |                                                                          |             
      Infarct                              |                4                                                         |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Vacuolization Cytoplasmic            |          3     3                       2     1  3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hyperplasia                          |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hyperplasia                          | 2                                                                        |             
      Hypertrophy                          |          1     1  1  2        2  1              2     2        2  1      |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +        +  +  +           +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hyperplasia                          |                                  2                             2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     M  +     M  +  +        +  +        +     +     +     +  +  +      |             
      Pars Distalis, Cyst                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +  +  +        +  +        +  +  +     +     +  +  +      |             
      Follicle, Cyst                       |                                              X                           |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 7| 2| 2| 7| 7| 4| 4| 7| 4| 7| 2| 7| 5| 7| 7| 7| 2| 2|             
                             DAY ON TEST   | 2| 5| 2| 2| 7| 2| 2| 2| 7| 7| 2| 2| 5| 5| 2| 5| 3| 7| 3| 8| 3| 3| 3| 7| 7|             
                                           | 9| 2| 9| 9| 6| 9| 9| 9| 7| 7| 9| 9| 3| 3| 9| 3| 0| 7| 0| 0| 0| 0| 0| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 +           +           +     +     +     +     +      |             
      Duct, Dilatation                     | 3                 4           3           3     3     4     4     3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +     +  +  M        +  +        +     +     M     +  +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +     +  +  +        +  +        +     M     +     +  +  +      |             
      Depletion Lymphoid                   | 2                                                                        |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M     M  M  M        M  M        M     M     M     M  M  M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Alopecia                             |                                                                   X      |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 7| 2| 2| 7| 7| 4| 4| 7| 4| 7| 2| 7| 5| 7| 7| 7| 2| 2|             
                             DAY ON TEST   | 2| 5| 2| 2| 7| 2| 2| 2| 7| 7| 2| 2| 5| 5| 2| 5| 3| 7| 3| 8| 3| 3| 3| 7| 7|             
                                           | 9| 2| 9| 9| 6| 9| 9| 9| 7| 7| 9| 9| 3| 3| 9| 3| 0| 7| 0| 0| 0| 0| 0| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Acinus, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3     2  2     2  1  1        2  1        3     2     2     3  4  3      |             
      Cortex, Cyst                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +  +  +        +  +        +     +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 2| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 7| 3| 3| 3| 3| 3| 0| 3|             
                                           | 0| 2| 0| 0| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 6| 1| 2| 9| 1| 2| 2| 2| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    1500 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     | X        X  X                          X                          X      |             
      Eosinophilic Focus                   |             X           X     X                                X         |             
      Infarct                              |                                                                      3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Vacuolization Cytoplasmic            | 2  2  3  2  2  3           2  1  2              3     2                 2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                2                                       |             
      Hypertrophy                          | 2     2  1  2  1     2  1  2  2  2  2                 2     2  2  2     2|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        3                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  M|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |          X                       X     X     X                          X|             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 2| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 7| 3| 3| 3| 3| 3| 0| 3|             
                                           | 0| 2| 0| 0| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 6| 1| 2| 9| 1| 2| 2| 2| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    1500 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +  +  +     +  +  +  +              +     +     +  +        +   |             
      Duct, Dilatation                     | 3        3  3  3     3  3  3  3              3     4     3  3        3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          4               |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +  +  +  +     +              +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     M  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               2  2           2           3               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                    4     4           4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M  +  +  +     +  +  +  +  +  +        M     M  +  +  +  +  +  M  +|             
      Depletion Lymphoid                   |                                                                2         |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M     M  M  M  M  M  M        M     M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                          X               |             
      Ulcer                                |                                                    4     3        2      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 2| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 7| 3| 3| 3| 3| 3| 0| 3|             
                                           | 0| 2| 0| 0| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 6| 1| 2| 9| 1| 2| 2| 2| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    1500 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                      +                  |             
      Hyperplasia                          |                                                                          |             
      Acinus, Dilatation                   |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 2     2  2  2  3     2  3  3  2  1  2        3     1  1  1  2  1  1     2|             
      Cortex, Cyst                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 2| 7| 4| 2|              |            |
                             DAY ON TEST   | 7| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1| 0| 7| 3| 5| 7|              |            |
                                           | 7| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 6| 1| 3| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +  +  +  +  A  +  +  +  +  +  +     +  M     +                     |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +                  |  59        |
      Clear Cell Focus                     |    X     X                    X  X                                       |     11     |
      Eosinophilic Focus                   |          X              X                                                |      6     |
      Infarct                              |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                               2  2     2  2                              |     21  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Acinus, Atrophy                      |          4  2                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Hyperplasia                          |                                                                          |      3  2.0|
      Hypertrophy                          |    2  2  2     2  2  2  1  2  2  2  2                                    |     37  1.8|
      Vacuolization Cytoplasmic            |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Hyperplasia                          |                         2                                                |      5  2.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  48        |
      Cyst                                 |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 2| 7| 4| 2|              |            |
                             DAY ON TEST   | 7| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1| 0| 7| 3| 5| 7|              |            |
                                           | 7| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 6| 1| 3| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  M  +  +  M  +  +     +  +     +                     |  44        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  51        |
      Follicle, Cyst                       |                         X                                                |      7     |
      Follicle, Dilatation                 |                2  1                                                      |      2  1.5|
      Follicular Cell, Hyperplasia, Focal  |                               2                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +  +     +  +     +                                          |  26        |
      Duct, Dilatation                     |             3  3     3        3                                          |     25  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Seminiferous Tubule, Atrophy         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +     +        +                     |  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  M  +  +  +  +  +     +        +                     |  46        |
      Hematopoietic Cell Proliferation     |          2     2                                                         |      7  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Hematopoietic Cell Proliferation     |             2                                                            |      4  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  M  +  +  +  +  +  +  +  +  +     +  M     +                     |  42        |
      Depletion Lymphoid                   |             2           3     3                                          |      5  2.4|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M  A  M  M  M  M  M  M  M  M  M     M  M     M                     |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Alopecia                             |                                                                          |      2     |
      Ulcer                                |                                                                          |      3  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 2| 7| 4| 2|              |            |
                             DAY ON TEST   | 7| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1| 0| 7| 3| 5| 7|              |            |
                                           | 7| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 6| 1| 3| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    1500 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                 +                              |   4        |
      Hyperplasia                          |                         3                                                |      1  3.0|
      Acinus, Dilatation                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
      Hydronephrosis                       |                         2                                                |      1  2.0|
      Nephropathy                          |    2  2  1  2  1  2  3  3  2  2  3  3     1  3     1                     |     48  2.0|
      Cortex, Cyst                         |                               X                                          |      3     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +     +  +     +                     |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 2| 2| 2| 4| 7| 2| 7| 7| 2| 7| 7| 7| 7| 7| 7| 4| 2| 7| 4|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 7| 7| 7| 5| 2| 7| 2| 2| 7| 2| 2| 3| 3| 3| 3| 1| 7| 3| 5|             
                                           | 3| 9| 9| 7| 9| 9| 6| 7| 6| 2| 9| 6| 9| 9| 7| 9| 9| 0| 0| 0| 0| 7| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +           +  +     +  +     +  +  +  +  +  +  +     +  +|             
      Basophilic Focus                     |                                     X                                    |             
      Clear Cell Focus                     |    X                       X        X                                    |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Infarct                              |                                                                          |             
      Vacuolization Cytoplasmic            | 2  2        1              3  3     2  1                 2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Hyperplasia, Focal, Squamous         |                                     2           1                    1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Dysplasia                            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Incisor, Abscess                     |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Spindle Cell, Accessory Adrenal      |                                                                          |             
          Cortical Nodule                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Hyperplasia                          |                1                                                         |             
      Hypertrophy                          |       1     1                 1     2           3  1     1  2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +              +     +  +     +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +              +     I  +     +  +  +  +  +  +  M     +   |             
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 2| 2| 2| 4| 7| 2| 7| 7| 2| 7| 7| 7| 7| 7| 7| 4| 2| 7| 4|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 7| 7| 7| 5| 2| 7| 2| 2| 7| 2| 2| 3| 3| 3| 3| 1| 7| 3| 5|             
                                           | 3| 9| 9| 7| 9| 9| 6| 7| 6| 2| 9| 6| 9| 9| 7| 9| 9| 0| 0| 0| 0| 7| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Hyperplasia         |             2                                                            |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |                                                                      X   |             
      Follicle, Dilatation                 |          1                                                               |             
      Follicular Cell, Hyperplasia, Focal  |                                     1                                1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +     +           +     +              +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                               3     3           4     3              3   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Granuloma Sperm                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  M     +   |             
      Hematopoietic Cell Proliferation     |                3                                            3            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  A     +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +              +     I  +     +  +  +  +  +  M  +     +   |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M              M     M  M     M  M  M  M  M  M  M     M   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Alopecia                             |                                                                          |             
      Ulcer                                |                                                             2            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 2| 2| 2| 4| 7| 2| 7| 7| 2| 7| 7| 7| 7| 7| 7| 4| 2| 7| 4|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 7| 7| 7| 5| 2| 7| 2| 2| 7| 2| 2| 3| 3| 3| 3| 1| 7| 3| 5|             
                                           | 3| 9| 9| 7| 9| 9| 6| 7| 6| 2| 9| 6| 9| 9| 7| 9| 9| 0| 0| 0| 0| 7| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Alveolar Epithelium, Hyperplasia     |          2                             2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
      Nephropathy                          |    2  2  2  3  3              2     2  2        2  2  2  2  2        3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +              +     +  +     +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 7| 3| 7| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 6| 1| 7| 1| 1| 3| 1| 1| 1| 2| 2| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    5000 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                                                   |             
      Clear Cell Focus                     |    X                       X                                             |             
      Eosinophilic Focus                   |                         X                                                |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              | 2                                                                        |             
      Vacuolization Cytoplasmic            | 2  2  2  2  2              1                    2     1           3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Hyperplasia, Focal, Squamous         |                            1                          1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Dysplasia                            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Abscess                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Spindle Cell, Accessory Adrenal      |                                                                          |             
          Cortical Nodule                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                       2                  |             
      Hypertrophy                          | 2  2  1  1  1  1           2  2     1     2  1     2  2  2  2  2     2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +     +     +     +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Hyperplasia                          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  M     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Pars Intermedia, Hyperplasia, Focal  |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 7| 3| 7| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 6| 1| 7| 1| 1| 3| 1| 1| 1| 2| 2| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    5000 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Rathke's Cleft, Cyst                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
      Follicle, Cyst                       |       X     X                             X     X                    1   |             
      Follicle, Dilatation                 |                                           1                          1  1|             
      Follicular Cell, Hyperplasia, Focal  |                1        1     4                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +              +           +        +     +                    +|             
      Inflammation, Chronic Active         |                                              4                           |             
      Duct, Dilatation                     |          3              3           3              3                    2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Granuloma Sperm                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  M  +  M  +  +     +  +  M     +     +  +     +  +  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Depletion Lymphoid                   | 3                             2           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M     M  M  M     M     M  M     M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Alopecia                             |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 7| 3| 7| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 6| 1| 7| 1| 1| 3| 1| 1| 1| 2| 2| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    5000 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Alveolar Epithelium, Hyperplasia     |                                     1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
      Hyperplasia                          |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
      Nephropathy                          | 1  2  2  2  3  3        2  2  2     2     2  2     2  2  3  2  1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +     +     +  +     +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 2| 7| 2| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 7| 3| 7| 3| 5| 3| 3| 3| 3| 3| 5| 3| 9| 3| 3|              |            |
                                           | 3| 2| 2| 2| 2| 6| 2| 7| 3| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     | X                          X                                             |      4     |
      Clear Cell Focus                     |                         X                                                |      6     |
      Eosinophilic Focus                   |       X                                         X                        |      3     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infarct                              |             2                                                            |      2  2.0|
      Vacuolization Cytoplasmic            |       2                 1           1  2     2           2               |     23  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Hyperplasia, Focal, Squamous         |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Dysplasia                            |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Abscess                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Spindle Cell, Accessory Adrenal      |                                                                          |            |
          Cortical Nodule                  |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Hyperplasia                          |    2        2                          1                                 |      5  1.6|
      Hypertrophy                          |       2  3              2     2  1  1     2     2        1               |     35  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 2| 7| 2| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 7| 3| 7| 3| 5| 3| 3| 3| 3| 3| 5| 3| 9| 3| 3|              |            |
                                           | 3| 2| 2| 2| 2| 6| 2| 7| 3| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
      Hyperplasia                          |                                           2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +     +     +     +  +  +  +  M     +  +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  49        |
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  3.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  52        |
      Inflammation, Chronic Active         |                   1                                                      |      2  1.5|
      Follicle, Cyst                       |                                        X                                 |      7  1.0|
      Follicle, Dilatation                 |                         1                                                |      5  1.0|
      Follicular Cell, Hyperplasia, Focal  |             2           1                                                |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +                 +     +  +  +           +  +  +                  |  20        |
      Inflammation, Chronic Active         |                                                       4                  |      2  4.0|
      Duct, Dilatation                     |    3  4                 4     4  3  3           3  3                     |     18  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +               |  52        |
      Granuloma Sperm                      |       2                                                                  |      1  2.0|
      Interstitial Cell, Hyperplasia       |                3                                                         |      1  3.0|
      Seminiferous Tubule, Atrophy         |                4                                                         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  M  +  +     +     +     +  +  +  +  +     +  +  +  +               |  45        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  M     +     +     +  +  +  +  +     +  +  M  +               |  47        |
      Depletion Lymphoid                   |                                  2                                       |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 2| 7| 2| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 7| 3| 7| 3| 5| 3| 3| 3| 3| 3| 5| 3| 9| 3| 3|              |            |
                                           | 3| 2| 2| 2| 2| 6| 2| 7| 3| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    5000 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M  M  M     M     M     M  M  M  M  M     M  M  M  M               |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Alopecia                             |       X                                                                  |      1     |
      Ulcer                                |                                  4              3                        |      3  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                  3              2                        |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +                     |   1        |
      Cornea, Inflammation, Chronic Active |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +                     |   3        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
      Nephropathy                          |    2  1  1              2     2  2  1  2  2     2  2  3  2               |     46  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +     +     +     +  +  +  +  +     +  +  +  +               |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 2| 4| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 5| 7| 5| 2| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3|             
                                           | 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 2| 3| 6| 2| 9| 0| 3| 0| 0| 0| 2| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                               X                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |          2           1  2  2  1  2           1  1  2                 1  1|             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                      2     2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                       4                  |             
      Hyperplasia, Focal, Squamous         |          4     2           2                          2  3               |             
      Inflammation, Chronic Active         |                1           3                             2               |             
      Ulcer                                |                            3                             3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
      Hypertrophy                          |    2              2  2                       1        1           2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 2| 4| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 5| 7| 5| 2| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3|             
                                           | 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 2| 3| 6| 2| 9| 0| 3| 0| 0| 0| 2| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                         X|             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Karyomegaly           |          2                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    1                     |             
      Follicle, Cyst                       |                            X  X                                          |             
      Follicle, Dilatation                 | 1        1  1     2  2  1     1  1     1        1                       1|             
      Follicular Cell, Hyperplasia, Focal  |                1  3  4  1  2                 4     1     1           1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +     +     +  +                 +  +        +        +     +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |    3  3  3     3     3  4                 3  4        3              3  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  I  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  M        M     M  M     M  M  M     M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 2| 4| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 5| 7| 5| 2| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3|             
                                           | 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 2| 3| 6| 2| 9| 0| 3| 0| 0| 0| 2| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | M  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          |    2  2  2     2  2  1  2  2              2  3     2  2  4     3  3  1  1|             
      Renal Tubule, Regeneration           |             1                 1  1              1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 6| 7| 2| 2| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 5| 3| 3| 7| 7| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 0| 1| 3| 1| 1| 3| 4| 1| 7| 7| 5| 1| 1| 1| 1| 7| 1| 1| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     15000                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                      X   |             
      Infarct                              |                                  4                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization, Focal                |                                                 2                        |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |    1     3              1        1     1           1  1        1         |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                               3                 1                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Erosion, Focal                       |                                        2                                 |             
      Hyperplasia, Focal, Squamous         |                      3                 2              2  2           2   |             
      Inflammation, Chronic Active         |                                        3                             1   |             
      Ulcer                                |                      3                                   2           1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          | 2  2           2                    1              1  1     2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 6| 7| 2| 2| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 5| 3| 3| 7| 7| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 0| 1| 3| 1| 1| 3| 4| 1| 7| 7| 5| 1| 1| 1| 1| 7| 1| 1| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     15000                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  A|             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Karyomegaly           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |                                                          X               |             
      Follicle, Dilatation                 | 1  1  1  1  1     1     2     1     1  1  1     1  1  1  1  1  1  1      |             
      Follicular Cell, Hyperplasia, Focal  |    1  1     2  1        3           1                 1        3  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +     +           +  +        +  +                    +  +  +      |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     | 3     3     3           3  3        3  3                    3  3  3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M|             
      Depletion Lymphoid                   |             2  2                       2                 2  1            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M  M     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Alopecia                             |                                           X                              |             
      Ulcer                                |                                           4                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 4| 6| 7| 2| 2| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 5| 3| 3| 7| 7| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 0| 0| 1| 3| 1| 1| 3| 4| 1| 7| 7| 5| 1| 1| 1| 1| 7| 1| 1| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     15000                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                      +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          | 1  2  1     1  1     2  4           2  1  2  2     2  1  1  1  1     1   |             
      Renal Tubule, Regeneration           |          1                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 2| 7| 7| 2| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 2|              |            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 3| 7| 7| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 4| 7|              |            |
                                           | 2| 2| 2| 7| 2| 2| 7| 6| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Diverticulum                         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Infarct                              |                                                    4                     |      2  4.0|
      Inflammation, Chronic Active         |                                                    3                     |      1  3.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Vacuolization Cytoplasmic            | 1     1                    2  3        2                                 |     24  1.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Acinus, Atrophy                      |                                                    2                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Erosion, Focal                       |                                                                          |      2  3.0|
      Hyperplasia, Focal, Squamous         | 2                          2                 2        2                  |     14  2.3|
      Inflammation, Chronic Active         |                                                                          |      5  2.0|
      Ulcer                                |                                              3                           |      6  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hyperplasia                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 2| 7| 7| 2| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 2|              |            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 3| 7| 7| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 4| 7|              |            |
                                           | 2| 2| 2| 7| 2| 2| 7| 6| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy                          | 2           2  1        2  1     1  2  1  1     2  2                     |     26  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +               |  67        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperplasia                          |                               2                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  64        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                     1                                    |      1  1.0|
      Pars Distalis, Karyomegaly           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Follicle, Cyst                       |       X                                X                                 |      5     |
      Follicle, Dilatation                 |       1  1     1     1  1     1           1        2     1               |     38  1.1|
      Follicular Cell, Hyperplasia, Focal  | 2           1              1     3  3  2  2  2     2                     |     27  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +           +        +  +           +  +     +  +                     |  31        |
      Inflammation, Chronic Active         |                                           4                              |      1  4.0|
      Duct, Dilatation                     | 3  3           3        3  3           3  3     3  3                     |     30  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +                  |  61        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  63        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hematopoietic Cell Proliferation     |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +               |  59        |
      Depletion Lymphoid                   |                                                                          |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05085-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:42:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 2| 7| 7| 2| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 2|              |            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 3| 7| 7| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 4| 7|              |            |
                                           | 2| 2| 2| 7| 2| 2| 7| 6| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     15000                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    PPM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M     +  M  M  M  M  M  M     M  M  M  M  M  M  M  M  M               |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Alopecia                             |             X                    X                                       |      3     |
      Ulcer                                |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +        +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |                                                       4                  |      1  4.0|
      Nephropathy                          | 2  2        2  2        2  1     1  1  2  2  1  2  2                     |     47  1.8|
      Renal Tubule, Regeneration           |       1                                                                  |      6  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Lumen, Hemorrhage                    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.