National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3568

TDMS Study 05085-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         MANGANESE SULFATE


NTP Experiment-Test: 05085-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 02:14:42




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           19           20                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            2            2            1                                     
    Moribund Sacrifice                                 6           11            6           11                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           42           36                                     
  Wrong Sex                                                                                   2                                     
  Animals Examined Microscopically                    70           61           62           68                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (70)         (51)         (50)         (68)                                   
      Parasite Metazoan                                1 (1%)                                 2 (3%)                                
   Intestine Large, Rectum                            (70)         (51)         (50)         (68)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Parasite Metazoan                                2 (3%)       2 (4%)       3 (6%)       2 (3%)                                
   Intestine Small, Jejunum                           (70)         (51)         (51)         (68)                                   
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Liver                                              (70)         (54)         (52)         (68)                                   
      Bacterium                                                                               1 (1%)                                
      Basophilic Focus                                45 (64%)     42 (78%)     36 (69%)     46 (68%)                               
      Clear Cell Focus                                 5 (7%)       3 (6%)       4 (8%)       7 (10%)                               
      Degeneration, Cystic                                          2 (4%)       3 (6%)       1 (1%)                                
      Hematopoietic Cell Proliferation                 1 (1%)                    1 (2%)       4 (6%)                                
      Hepatodiaphragmatic Nodule                       7 (10%)      9 (17%)      6 (12%)      8 (12%)                               
      Hyperplasia                                      1 (1%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic                           34 (49%)     35 (65%)     31 (60%)     43 (63%)                               
      Leukocytosis                                     1 (1%)                                 1 (1%)                                
      Necrosis, Coagulative                            3 (4%)       3 (6%)       3 (6%)       2 (3%)                                
      Thrombosis                                       1 (1%)                                                                       
      Vacuolization Cytoplasmic                       16 (23%)     15 (28%)     18 (35%)     17 (25%)                               
      Bile Duct, Cyst                                  1 (1%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          36 (51%)     31 (57%)     35 (67%)     33 (49%)                               
   Mesentery                                          (3)          (4)          (5)          (2)                                    
      Inflammation, Chronic Active                                               1 (20%)                                            
      Inflammation, Necrotizing                        2 (67%)      3 (75%)      1 (20%)      1 (50%)                               
      Necrosis                                                      1 (25%)      1 (20%)                                            
   Pancreas                                           (70)         (50)         (50)         (68)                                   
      Infiltration Cellular, Lipocyte                 34 (49%)     31 (62%)     36 (72%)     27 (40%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Acinus, Amyloid Deposition                       1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy                                 10 (14%)     16 (32%)     13 (26%)     14 (21%)                               
      Perivascular, Inflammation, Chronic Active       1 (1%)                                 1 (1%)                                
   Salivary Glands                                    (70)         (51)         (50)         (68)                                   
      Atrophy                                                                                 1 (1%)                                
      Acinus, Hyperplasia                              1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (51)         (50)         (68)                                   
      Acanthosis                                       4 (6%)       5 (10%)      4 (8%)       7 (10%)                               
      Hyperkeratosis                                   1 (1%)       1 (2%)       2 (4%)       2 (3%)                                
      Inflammation, Chronic Active                     3 (4%)       3 (6%)       1 (2%)       3 (4%)                                
      Perforation                                                                             1 (1%)                                
   Stomach, Glandular                                 (70)         (51)         (50)         (68)                                   
      Erosion                                          1 (1%)       1 (2%)                                                          
      Inflammation, Chronic Active                     4 (6%)       4 (8%)                    1 (1%)                                
      Mineralization                                                1 (2%)                                                          
   Tooth                                              (60)         (51)         (51)         (58)                                   
      Inflammation, Chronic Active                                  3 (6%)       2 (4%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (51)         (51)         (68)                                   
      Cardiomyopathy, Chronic                         38 (55%)     32 (63%)     34 (67%)     38 (56%)                               
      Degeneration, Chronic                            2 (3%)                                 2 (3%)                                
      Atrium, Thrombosis                               1 (1%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (51)         (51)         (68)                                   
      Degeneration, Fatty                             27 (39%)     23 (45%)     28 (55%)     27 (40%)                               
      Hematocyst                                       1 (1%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (1%)                                
      Hyperplasia                                     25 (36%)     23 (45%)     24 (47%)     20 (29%)                               
      Hypertrophy                                      5 (7%)       2 (4%)       3 (6%)       1 (1%)                                
   Adrenal Gland, Medulla                             (70)         (51)         (51)         (68)                                   
      Hematopoietic Cell Proliferation                                                        1 (1%)                                
      Hyperplasia                                     12 (17%)     11 (22%)      6 (12%)      1 (1%)                                
   Islets, Pancreatic                                 (70)         (50)         (50)         (68)                                   
      Hyperplasia                                                   1 (2%)                    1 (1%)                                
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Parathyroid Gland                                  (62)         (47)         (46)         (65)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (70)         (51)         (51)         (67)                                   
      Craniopharyngeal Duct, Cyst                      1 (1%)                    2 (4%)       2 (3%)                                
      Pars Distalis, Angiectasis                       1 (1%)                                                                       
      Pars Distalis, Congestion                                                               1 (1%)                                
      Pars Distalis, Cyst                             37 (53%)     29 (57%)     23 (45%)     28 (42%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                      23 (33%)     24 (47%)     24 (47%)     20 (30%)                               
      Pars Intermedia, Cyst                            1 (1%)                    1 (2%)                                             
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (69)         (51)         (50)         (67)                                   
      C-Cell, Hyperplasia                             17 (25%)     12 (24%)      9 (18%)     19 (28%)                               
      Follicular Cell, Cyst                                                                   1 (1%)                                
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (69)         (51)         (47)         (63)                                   
      Hyperplasia                                      5 (7%)       4 (8%)      10 (21%)      6 (10%)                               
      Inflammation, Chronic Active                    21 (30%)     15 (29%)     12 (26%)     23 (37%)                               
      Duct, Cyst                                                                              1 (2%)                                
      Duct, Ectasia                                    1 (1%)       1 (2%)                    1 (2%)                                
   Ovary                                              (70)         (53)         (51)         (67)                                   
      Atrophy                                                       3 (6%)       1 (2%)       1 (1%)                                
      Cyst                                             6 (9%)       7 (13%)      4 (8%)       2 (3%)                                
   Oviduct                                            (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
      Inflammation, Acute                              1 (100%)                                                                     
   Uterus                                             (70)         (51)         (53)         (67)                                   
      Dilatation                                                    1 (2%)       2 (4%)       1 (1%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Cystic, Glandular                   3 (4%)       4 (8%)       8 (15%)      5 (7%)                                
      Inflammation, Chronic Active                     1 (1%)       1 (2%)       1 (2%)                                             
      Intussusception                                               1 (2%)                                                          
      Endometrium, Hyperplasia                         1 (1%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular      1 (1%)                                 1 (1%)                                
   Vagina                                             (1)                       (1)                                                 
      Inflammation, Suppurative                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (41)         (48)         (48)         (48)                                   
      Polycythemia                                                                            1 (2%)                                
   Bone Marrow                                        (70)         (51)         (51)         (68)                                   
      Femoral, Hyperplasia, Erythrocyte                                                       1 (1%)                                
      Femoral, Myelofibrosis                           1 (1%)       1 (2%)       1 (2%)       1 (1%)                                
   Lymph Node                                         (70)         (51)         (51)         (68)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Inflammation, Chronic Active                   1 (2%)                                                          
      Inguinal, Cyst                                                1 (2%)                                                          
      Lumbar, Cyst                                                  1 (2%)                                                          
      Mediastinal, Inflammation, Chronic Active        1 (1%)                                                                       
   Lymph Node, Mandibular                             (70)         (51)         (50)         (67)                                   
      Cyst                                             4 (6%)                    2 (4%)       3 (4%)                                
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
   Spleen                                             (70)         (51)         (51)         (68)                                   
      Fibrosis                                                                   2 (4%)                                             
      Hematopoietic Cell Proliferation                 2 (3%)       3 (6%)       1 (2%)       4 (6%)                                
      Lymphoid Follicle, Hyperplasia                   1 (1%)                                 1 (1%)                                
   Thymus                                             (64)         (49)         (47)         (65)                                   
      Cyst                                             2 (3%)       2 (4%)                    1 (2%)                                
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (66)         (50)         (51)         (65)                                   
      Hyperplasia, Cystic                             53 (80%)     49 (98%)     49 (96%)     56 (86%)                               
   Skin                                               (70)         (51)         (51)         (65)                                   
      Cyst Epithelial Inclusion                        1 (1%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (51)         (68)                                   
      Compression                                      4 (6%)       7 (14%)      1 (2%)       3 (4%)                                
      Hydrocephalus                                    3 (4%)       6 (12%)      1 (2%)       5 (7%)                                
      Necrosis                                                                                1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (69)         (51)         (51)         (68)                                   
      Bacterium                                                                               1 (1%)                                
      Infiltration Cellular, Histiocyte               27 (39%)     35 (69%)     32 (63%)     29 (43%)                               
      Inflammation, Chronic Active                     8 (12%)      8 (16%)      8 (16%)      9 (13%)                               
      Leukocytosis                                                                            1 (1%)                                
      Metaplasia, Osseous                              4 (6%)                                                                       
      Necrosis, Coagulative                                                                   1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 1 (1%)       4 (8%)       6 (12%)      4 (6%)                                
   Nose                                               (70)         (51)         (51)         (68)                                   
      Fungus                                           1 (1%)       1 (2%)       2 (4%)       4 (6%)                                
      Inflammation, Chronic Active                     3 (4%)       2 (4%)       6 (12%)      5 (7%)                                
      Nasolacrimal Duct, Inflammation, Suppurative    19 (27%)     15 (29%)     16 (31%)     21 (31%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (2)          (1)          (4)                                    
      Cornea, Inflammation, Chronic Active                          1 (50%)                                                         
      Lens, Cataract                                   3 (75%)      2 (100%)     1 (100%)     4 (100%)                              
      Retina, Atrophy                                  3 (75%)      2 (100%)     1 (100%)     3 (75%)                               
   Harderian Gland                                    (60)         (51)         (50)         (58)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (59)         (61)         (68)                                   
      Bacterium                                                                               1 (1%)                                
      Hydronephrosis                                                                          1 (1%)                                
      Inflammation, Chronic Active                                                            1 (1%)                                
      Necrosis, Coagulative                            1 (1%)                                                                       
      Nephropathy, Chronic                            58 (83%)     59 (100%)    59 (97%)     60 (88%)                               
      Thrombosis                                       1 (1%)                                                                       
      Renal Tubule, Hyperplasia                                     2 (3%)                                                          
      Renal Tubule, Hyperplasia, Oncocytic             1 (1%)                                                                       
   Urinary Bladder                                    (69)         (51)         (51)         (68)                                   
      Inflammation, Hemorrhagic                                                               1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 18           19           19           18                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6           10            5            7                                     
    Moribund Sacrifice                                21           24           24           38                                     
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                25           17           21            7                                     
  Animals Examined Microscopically                    70           70           70           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (70)         (51)         (50)         (69)                                   
      Inflammation, Chronic Active                     1 (1%)       1 (2%)                    1 (1%)                                
      Parasite Metazoan                                1 (1%)                                 1 (1%)                                
   Intestine Large, Colon                             (70)         (52)         (50)         (70)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Mineralization                                                1 (2%)                                                          
      Parasite Metazoan                                1 (1%)       4 (8%)       4 (8%)       1 (1%)                                
   Intestine Large, Rectum                            (70)         (52)         (51)         (70)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Parasite Metazoan                                3 (4%)       3 (6%)       2 (4%)       2 (3%)                                
      Thrombosis                                                    1 (2%)                                                          
   Intestine Small, Ileum                             (70)         (51)         (51)         (69)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
   Liver                                              (70)         (53)         (52)         (70)                                   
      Basophilic Focus                                12 (17%)      9 (17%)     10 (19%)      9 (13%)                               
      Clear Cell Focus                                 3 (4%)       5 (9%)       3 (6%)       3 (4%)                                
      Degeneration, Cystic                            16 (23%)     19 (36%)     19 (37%)     12 (17%)                               
      Hepatodiaphragmatic Nodule                       2 (3%)       3 (6%)       1 (2%)       2 (3%)                                
      Hyperplasia                                      2 (3%)       2 (4%)                    2 (3%)                                
      Inflammation, Chronic                           26 (37%)     30 (57%)     25 (48%)     31 (44%)                               
      Leukocytosis                                                  2 (4%)       2 (4%)                                             
      Necrosis, Coagulative                            4 (6%)       4 (8%)       4 (8%)       1 (1%)                                
      Thrombosis                                                                 1 (2%)       1 (1%)                                
      Vacuolization Cytoplasmic                       23 (33%)     23 (43%)     24 (46%)     21 (30%)                               
      Bile Duct, Hyperplasia                          48 (69%)     50 (94%)     48 (92%)     47 (67%)                               
      Hepatocyte, Atrophy                                                        1 (2%)                                             
   Mesentery                                          (8)          (9)          (5)          (6)                                    
      Inflammation, Chronic Active                     2 (25%)                                                                      
      Inflammation, Necrotizing                        3 (38%)      6 (67%)      5 (100%)     5 (83%)                               
   Pancreas                                           (70)         (51)         (51)         (69)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst                                             2 (3%)                                 1 (1%)                                
      Ectopic Tissue                                                1 (2%)                                                          
      Infiltration Cellular, Lipocyte                 20 (29%)     13 (25%)     25 (49%)     14 (20%)                               
      Acinus, Atrophy                                 26 (37%)     28 (55%)     18 (35%)     22 (32%)                               
      Acinus, Hyperplasia                              2 (3%)       1 (2%)       1 (2%)                                             
      Perivascular, Inflammation, Chronic Active       6 (9%)       2 (4%)       2 (4%)       3 (4%)                                
   Salivary Glands                                    (70)         (48)         (51)         (69)                                   
      Sublingual Gland, Hyperplasia                    1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (54)         (52)         (70)                                   
      Acanthosis                                      19 (27%)     12 (22%)     11 (21%)     11 (16%)                               
      Diverticulum                                                  1 (2%)                                                          
      Hyperkeratosis                                   3 (4%)       3 (6%)       6 (12%)      2 (3%)                                
      Inflammation, Chronic Active                    11 (16%)      8 (15%)      8 (15%)      8 (11%)                               
      Mineralization                                   2 (3%)       4 (7%)       3 (6%)       2 (3%)                                
   Stomach, Glandular                                 (70)         (52)         (52)         (70)                                   
      Erosion                                                       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                     4 (6%)       8 (15%)      8 (15%)      4 (6%)                                
      Mineralization                                   8 (11%)     13 (25%)      9 (17%)     23 (33%)                               
   Tooth                                              (61)         (50)         (51)         (59)                                   
      Caries                                                                                  1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (52)         (51)         (51)         (52)                                   
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       1 (2%)                                
      Mineralization                                   4 (8%)      10 (20%)      6 (12%)     17 (33%)                               
      Thrombosis                                                                 1 (2%)       1 (2%)                                
   Heart                                              (70)         (52)         (51)         (70)                                   
      Cardiomyopathy, Chronic                         57 (81%)     48 (92%)     51 (100%)    52 (74%)                               
      Degeneration, Chronic                            8 (11%)                                6 (9%)                                
      Mineralization                                   4 (6%)       8 (15%)      5 (10%)      9 (13%)                               
      Atrium, Thrombosis                               5 (7%)       5 (10%)      5 (10%)                                            
      Valve, Inflammation, Chronic Active                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (52)         (51)         (70)                                   
      Accessory Adrenal Cortical Nodule                1 (1%)                                 1 (1%)                                
      Atypia Cellular                                                                         1 (1%)                                
      Degeneration, Fatty                             33 (47%)     27 (52%)     32 (63%)     28 (40%)                               
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia                                     21 (30%)     14 (27%)     17 (33%)     18 (26%)                               
      Hypertrophy                                      4 (6%)       1 (2%)       2 (4%)       2 (3%)                                
      Necrosis, Coagulative                            1 (1%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Gland, Medulla                             (70)         (52)         (51)         (70)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                     28 (40%)     23 (44%)     31 (61%)     27 (39%)                               
   Islets, Pancreatic                                 (70)         (51)         (51)         (69)                                   
      Hyperplasia                                                   2 (4%)       2 (4%)       3 (4%)                                
   Parathyroid Gland                                  (68)         (47)         (49)         (66)                                   
      Hyperplasia                                     14 (21%)     14 (30%)     12 (24%)     23 (35%)                               
   Pituitary Gland                                    (69)         (50)         (51)         (68)                                   
      Mineralization                                                                          1 (1%)                                
      Craniopharyngeal Duct, Cyst                                   1 (2%)       1 (2%)       2 (3%)                                
      Pars Distalis, Cyst                              8 (12%)      7 (14%)      2 (4%)       8 (12%)                               
      Pars Distalis, Hyperplasia                      21 (30%)     15 (30%)     18 (35%)     13 (19%)                               
      Pars Distalis, Hypertrophy                       1 (1%)                                                                       
      Pars Intermedia, Cyst                                         2 (4%)       1 (2%)       6 (9%)                                
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (70)         (49)         (51)         (69)                                   
      C-Cell, Hyperplasia                             19 (27%)     12 (24%)     15 (29%)      6 (9%)                                
      Follicle, Cyst Multilocular                      1 (1%)                    1 (2%)       1 (1%)                                
      Follicular Cell, Mineralization                  1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (3)          (1)          (1)                                    
      Inflammation, Chronic Active                     1 (100%)     2 (67%)      1 (100%)     1 (100%)                              
   Epididymis                                         (70)         (52)         (51)         (70)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Mineralization                                                             1 (2%)       1 (1%)                                
   Preputial Gland                                    (70)         (53)         (52)         (70)                                   
      Hyperplasia                                      3 (4%)       3 (6%)                    2 (3%)                                
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Chronic Active                    52 (74%)     50 (94%)     45 (87%)     53 (76%)                               
      Duct, Ectasia                                    1 (1%)                                                                       
   Prostate                                           (70)         (52)         (51)         (69)                                   
      Cyst                                             1 (1%)       2 (4%)       1 (2%)                                             
      Inflammation, Acute                                                                     2 (3%)                                
      Inflammation, Chronic Active                    40 (57%)     38 (73%)     44 (86%)     48 (70%)                               
      Mineralization                                   1 (1%)       1 (2%)                                                          
      Thrombosis                                                                              1 (1%)                                
      Epithelium, Hyperplasia                          1 (1%)                                                                       
   Seminal Vesicle                                    (70)         (52)         (51)         (70)                                   
      Hyperplasia                                                                             1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (1%)                    2 (4%)                                             
      Mineralization                                                                          2 (3%)                                
   Testes                                             (70)         (54)         (51)         (70)                                   
      Mineralization                                  25 (36%)     31 (57%)     22 (43%)     29 (41%)                               
      Necrosis, Coagulative                                                                   1 (1%)                                
      Interstitial Cell, Hyperplasia                  20 (29%)     15 (28%)     10 (20%)     27 (39%)                               
      Seminiferous Tubule, Atrophy                     3 (4%)       5 (9%)       3 (6%)       8 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (46)         (42)         (44)         (41)                                   
      Leukocytosis                                                  1 (2%)       2 (5%)                                             
   Bone Marrow                                        (70)         (52)         (51)         (70)                                   
      Femoral, Atrophy                                                           2 (4%)                                             
      Femoral, Myelofibrosis                                        2 (4%)                                                          
   Lymph Node                                         (70)         (52)         (51)         (70)                                   
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
      Pancreatic, Inflammation, Chronic Active                                                1 (1%)                                
      Renal, Hyperplasia, Plasma Cell                               1 (2%)                                                          
   Lymph Node, Mandibular                             (69)         (48)         (51)         (68)                                   
      Cyst                                             5 (7%)       7 (15%)      3 (6%)       2 (3%)                                
      Hyperplasia, Plasma Cell                         2 (3%)                    3 (6%)                                             
   Lymph Node, Mesenteric                             (68)         (51)         (51)         (69)                                   
      Cyst                                             1 (1%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                    1 (1%)                                
   Spleen                                             (70)         (52)         (51)         (70)                                   
      Fibrosis                                         4 (6%)       6 (12%)      7 (14%)      3 (4%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       4 (8%)       4 (8%)       1 (1%)                                
      Infiltration Cellular, Lipocyte                  1 (1%)       1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)       1 (2%)                                             
      Thrombosis                                                                              1 (1%)                                
   Thymus                                             (66)         (48)         (49)         (62)                                   
      Cyst                                                                                    1 (2%)                                
      Ectopic Parathyroid Gland                        2 (3%)       1 (2%)                                                          
      Ectopic Thyroid                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (39)         (36)         (53)                                   
      Hyperplasia, Cystic                             44 (76%)     38 (97%)     36 (100%)    39 (74%)                               
   Skin                                               (65)         (52)         (50)         (70)                                   
      Acanthosis                                       2 (3%)       1 (2%)                                                          
      Alopecia                                                      1 (2%)       1 (2%)                                             
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)                                 2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic Active                     2 (3%)       4 (8%)       3 (6%)       1 (1%)                                
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (52)         (51)         (70)                                   
      Cranium, Fibrous Osteodystrophy                 12 (17%)     13 (25%)     11 (22%)     23 (33%)                               
      Femur, Fibrous Osteodystrophy                   12 (17%)     14 (27%)     12 (24%)     24 (34%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (51)         (70)                                   
      Compression                                      4 (6%)       4 (8%)       7 (14%)      4 (6%)                                
      Hydrocephalus                                    4 (6%)       5 (10%)      8 (16%)      5 (7%)                                
      Necrosis                                         1 (1%)                    1 (2%)                                             
   Spinal Cord                                        (1)          (2)                       (1)                                    
      White Matter, Degeneration                                    1 (50%)                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (52)         (51)         (70)                                   
      Hemorrhage                                                                              1 (1%)                                
      Infiltration Cellular, Histiocyte               12 (17%)     18 (35%)      9 (18%)     11 (16%)                               
      Inflammation, Chronic Active                     5 (7%)       9 (17%)      9 (18%)      8 (11%)                               
      Leukocytosis                                                  1 (2%)       2 (4%)                                             
      Metaplasia, Osseous                              1 (1%)       4 (8%)       2 (4%)       3 (4%)                                
      Mineralization                                   4 (6%)       6 (12%)      6 (12%)     10 (14%)                               
      Thrombosis                                       1 (1%)       1 (2%)                    1 (1%)                                
      Alveolar Epithelium, Hyperplasia                 2 (3%)       3 (6%)       5 (10%)      1 (1%)                                
      Mediastinum, Inflammation, Chronic Active                     1 (2%)                                                          
   Nose                                               (70)         (51)         (51)         (70)                                   
      Fungus                                           2 (3%)       4 (8%)                    1 (1%)                                
      Inflammation, Chronic Active                     7 (10%)      9 (18%)      7 (14%)     11 (16%)                               
      Nasolacrimal Duct, Inflammation, Suppurative    18 (26%)     16 (31%)     18 (35%)     17 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (6)          (10)                                   
      Anterior Chamber, Inflammation, Suppurative                                             1 (10%)                               
      Cornea, Inflammation, Chronic Active             1 (33%)      1 (50%)      3 (50%)      5 (50%)                               
      Cornea, Mineralization                           1 (33%)                   3 (50%)      6 (60%)                               
      Lens, Cataract                                   1 (33%)      1 (50%)      2 (33%)      2 (20%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Retina, Atrophy                                  1 (33%)      1 (50%)      2 (33%)      2 (20%)                               
   Harderian Gland                                    (62)         (51)         (51)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (69)         (70)         (70)                                   
      Hydronephrosis                                   1 (1%)                                                                       
      Infarct                                                                    1 (1%)                                             
      Nephropathy, Chronic                            68 (97%)     68 (99%)     70 (100%)    68 (97%)                               
      Thrombosis                                                                 1 (1%)       1 (1%)                                
      Glomerulus, Inflammation, Chronic Active                      1 (1%)                                                          
      Renal Tubule, Hyperplasia                        1 (1%)       3 (4%)                    2 (3%)                                
      Renal Tubule, Hyperplasia, Oncocytic                          1 (1%)                                                          
   Urinary Bladder                                    (70)         (51)         (51)         (70)                                   
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (1%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.