National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3572

TDMS Study 05085-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         MANGANESE SULFATE


NTP Experiment-Test: 05085-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 02:14:45




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           19           20                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            2            2            1                                     
    Moribund Sacrifice                                 6           11            6           11                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           42           36                                     
  Wrong Sex                                                                                   2                                     
  Animals Examined Microscopically                    70           61           62           68                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (70)         (51)         (50)         (68)                                   
      Adenocarcinoma                                                                          1 (1%)                                
   Liver                                              (70)         (54)         (52)         (68)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                                                     1 (2%)                                             
   Mesentery                                          (3)          (4)          (5)          (2)                                    
      Liposarcoma                                                                1 (20%)                                            
   Pancreas                                           (70)         (50)         (50)         (68)                                   
   Salivary Glands                                    (70)         (51)         (50)         (68)                                   
   Stomach, Forestomach                               (70)         (51)         (50)         (68)                                   
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (70)         (51)         (50)         (68)                                   
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (51)         (51)         (68)                                   
      Schwannoma Malignant, Metastatic, Lung                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (51)         (51)         (68)                                   
      Adenoma                                          1 (1%)       1 (2%)                                                          
      Carcinoma                                        1 (1%)                                                                       
   Adrenal Gland, Medulla                             (70)         (51)         (51)         (68)                                   
      Pheochromocytoma Complex                         1 (1%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          1 (1%)                    4 (8%)       1 (1%)                                
   Islets, Pancreatic                                 (70)         (50)         (50)         (68)                                   
      Adenoma                                                                    1 (2%)                                             
   Parathyroid Gland                                  (62)         (47)         (46)         (65)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Pituitary Gland                                    (70)         (51)         (51)         (67)                                   
      Pars Distalis, Adenoma                          22 (31%)     17 (33%)     19 (37%)     22 (33%)                               
      Pars Distalis, Adenoma, Multiple                 1 (1%)                                                                       
      Pars Distalis, Carcinoma                                      1 (2%)                    2 (3%)                                
   Thyroid Gland                                      (69)         (51)         (50)         (67)                                   
      Bilateral, C-Cell, Adenoma                                                              2 (3%)                                
      C-Cell, Adenoma                                  8 (12%)      6 (12%)      6 (12%)      6 (9%)                                
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      C-Cell, Carcinoma                                1 (1%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Adenoma                                                                1 (1%)                                
      Follicular Cell, Carcinoma                       1 (1%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (69)         (51)         (47)         (63)                                   
      Adenoma                                          5 (7%)       1 (2%)       6 (13%)      2 (3%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Ovary                                              (70)         (53)         (51)         (67)                                   
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                                   1 (2%)                    1 (1%)                                
      Granulosa-Theca Tumor Benign                                                            1 (1%)                                
   Uterus                                             (70)         (51)         (53)         (67)                                   
      Hemangiosarcoma                                                                         1 (1%)                                
      Leiomyoma                                                                               1 (1%)                                
      Polyp Stromal                                   13 (19%)      7 (14%)      8 (15%)      7 (10%)                               
      Sarcoma Stromal                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (41)         (48)         (48)         (48)                                   
   Bone Marrow                                        (70)         (51)         (51)         (68)                                   
   Lymph Node                                         (70)         (51)         (51)         (68)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                          1 (2%)                                             
      Mediastinal, Rhabdomyosarcoma, Metastatic,                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
           Skeletal Muscle                                                                    1 (1%)                                
   Lymph Node, Mandibular                             (70)         (51)         (50)         (67)                                   
   Lymph Node, Mesenteric                             (69)         (51)         (51)         (66)                                   
   Spleen                                             (70)         (51)         (51)         (68)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (64)         (49)         (47)         (65)                                   
      Carcinoma, Metastatic                                                      1 (2%)                                             
      Thymoma Benign                                   2 (3%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (66)         (50)         (51)         (65)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Fibroadenoma                                    15 (23%)     14 (28%)     26 (51%)     11 (17%)                               
      Fibroadenoma, Multiple                           4 (6%)       2 (4%)                    5 (8%)                                
   Skin                                               (70)         (51)         (51)         (65)                                   
      Basal Cell Adenoma                               1 (1%)                                                                       
      Basal Cell Carcinoma                             1 (1%)                                                                       
      Basosquamous Tumor Benign                                     1 (2%)                                                          
      Keratoacanthoma                                               1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (50)         (51)         (48)                                   
      Rhabdomyosarcoma                                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (51)         (68)                                   
      Carcinoma, Metastatic, Pituitary Gland                                                  2 (3%)                                
      Granular Cell Tumor Benign                                                              1 (1%)                                
      Oligodendroglioma NOS                                                                   1 (1%)                                
   Spinal Cord                                                     (1)                                                              
      Schwannoma NOS                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (69)         (51)         (51)         (68)                                   
      Alveolar/Bronchiolar Adenoma                     1 (1%)       1 (2%)                    2 (3%)                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Mediastinum, Rhabdomyosarcoma, Metastatic,                                                                                    
           Skeletal Muscle                                                                    1 (1%)                                
      Mediastinum, Schwannoma Malignant                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (59)         (61)         (68)                                   
      Liposarcoma, Metastatic, Mesentery                                         1 (2%)                                             
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (69)         (51)         (51)         (68)                                   
      Transitional Epithelium, Papilloma               1 (1%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(61)        *(62)        *(68)                                   
      Leukemia Mononuclear                            19 (27%)     21 (34%)     26 (42%)     18 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          47          51          44                                       
     Total Primary Neoplasms                           99          89         108          88                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          36          45          38                                       
     Total Benign Neoplasms                            75          56          75          64                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          26          30          22                                       
     Total Malignant Neoplasms                         24          32          33          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          3           3           3                                       
     Total Metastatic Neoplasm                                      3           3           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                       1                                       
     Total Uncertain Neoplasms                                      1                       1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 18           19           19           18                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6           10            5            7                                     
    Moribund Sacrifice                                21           24           24           38                                     
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                25           17           21            7                                     
  Animals Examined Microscopically                    70           70           70           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (70)         (51)         (50)         (69)                                   
   Intestine Large, Colon                             (70)         (52)         (50)         (70)                                   
   Intestine Large, Rectum                            (70)         (52)         (51)         (70)                                   
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Polyp Adenomatous                                                                       1 (1%)                                
   Intestine Small, Duodenum                          (70)         (52)         (51)         (70)                                   
   Intestine Small, Ileum                             (70)         (51)         (51)         (69)                                   
   Intestine Small, Jejunum                           (70)         (52)         (51)         (69)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Liver                                              (70)         (53)         (52)         (70)                                   
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Histiocytic Sarcoma                              1 (1%)                                                                       
   Mesentery                                          (8)          (9)          (5)          (6)                                    
   Pancreas                                           (70)         (51)         (51)         (69)                                   
      Acinus, Adenoma                                               2 (4%)       1 (2%)                                             
   Pharynx                                            (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Salivary Glands                                    (70)         (48)         (51)         (69)                                   
   Stomach, Forestomach                               (70)         (54)         (52)         (70)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Squamous Cell Papilloma, Multiple                                                       1 (1%)                                
   Stomach, Glandular                                 (70)         (52)         (52)         (70)                                   
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Tooth                                              (61)         (50)         (51)         (59)                                   
      Gingiva, Squamous Cell Carcinoma                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (52)         (51)         (70)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (52)         (51)         (70)                                   
      Adenoma                                          1 (1%)                                 1 (1%)                                
   Adrenal Gland, Medulla                             (70)         (52)         (51)         (70)                                   
      Pheochromocytoma Malignant                       1 (1%)                    1 (2%)                                             
      Pheochromocytoma Complex                                      1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                          9 (13%)     12 (23%)     12 (24%)      4 (6%)                                
      Bilateral, Pheochromocytoma Benign               5 (7%)       5 (10%)      2 (4%)       2 (3%)                                
   Islets, Pancreatic                                 (70)         (51)         (51)         (69)                                   
      Adenoma                                                       3 (6%)       4 (8%)       3 (4%)                                
      Carcinoma                                                                               1 (1%)                                
      Mixed Tumor Benign                                            1 (2%)                                                          
   Parathyroid Gland                                  (68)         (47)         (49)         (66)                                   
      Adenoma                                          1 (1%)                                                                       
   Pituitary Gland                                    (69)         (50)         (51)         (68)                                   
      Ependymoma Malignant, Metastatic, Brain                                                 1 (1%)                                
      Pars Distalis, Adenoma                          13 (19%)     12 (24%)     14 (27%)     14 (21%)                               
      Pars Distalis, Adenoma, Multiple                                           1 (2%)       1 (1%)                                
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
      Pars Intermedia, Carcinoma                                    1 (2%)                                                          
   Thyroid Gland                                      (70)         (49)         (51)         (69)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  6 (9%)       6 (12%)      7 (14%)      4 (6%)                                
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      C-Cell, Carcinoma                                                                       1 (1%)                                
      Follicular Cell, Adenoma                         1 (1%)       1 (2%)       1 (2%)       3 (4%)                                
      Follicular Cell, Carcinoma                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (52)         (51)         (70)                                   
   Preputial Gland                                    (70)         (53)         (52)         (70)                                   
      Adenoma                                          3 (4%)       2 (4%)       2 (4%)                                             
      Carcinoma                                        2 (3%)       2 (4%)       1 (2%)       2 (3%)                                
      Bilateral, Carcinoma                                                       3 (6%)                                             
   Prostate                                           (70)         (52)         (51)         (69)                                   
   Seminal Vesicle                                    (70)         (52)         (51)         (70)                                   
   Testes                                             (70)         (54)         (51)         (70)                                   
      Bilateral, Interstitial Cell, Adenoma           36 (51%)     31 (57%)     33 (65%)     31 (44%)                               
      Interstitial Cell, Adenoma                      12 (17%)     13 (24%)      9 (18%)     12 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (46)         (42)         (44)         (41)                                   
   Bone Marrow                                        (70)         (52)         (51)         (70)                                   
      Femoral, Fibrosarcoma                            1 (1%)                                                                       
   Lymph Node                                         (70)         (52)         (51)         (70)                                   
      Renal, Carcinoma, Metastatic, Kidney                                                    1 (1%)                                
   Lymph Node, Mandibular                             (69)         (48)         (51)         (68)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Lymph Node, Mesenteric                             (68)         (51)         (51)         (69)                                   
   Spleen                                             (70)         (52)         (51)         (70)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Hemangioma                                       1 (1%)                                                                       
   Thymus                                             (66)         (48)         (49)         (62)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (39)         (36)         (53)                                   
      Fibroadenoma                                     1 (2%)                    1 (3%)       2 (4%)                                
   Skin                                               (65)         (52)         (50)         (70)                                   
      Basal Cell Adenoma                                                         2 (4%)                                             
      Basal Cell Carcinoma                             1 (2%)                    1 (2%)                                             
      Basosquamous Tumor Benign                                                  1 (2%)                                             
      Keratoacanthoma                                  1 (2%)                    1 (2%)                                             
      Keratoacanthoma, Multiple                                                               1 (1%)                                
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)       1 (1%)                                
      Trichoepithelioma                                                          1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                                            1 (1%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                                               2 (3%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Neurofibroma                                          1 (2%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Neurofibrosarcoma           2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (52)         (51)         (70)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (1%)                                
      Squamous Cell Carcinoma, Metastatic, Tooth                                 1 (2%)                                             
      Femur, Fibrosarcoma                              1 (1%)                                                                       
   Skeletal Muscle                                    (52)         (51)         (51)         (52)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (51)         (70)                                   
      Astrocytoma Malignant                            2 (3%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)       1 (2%)                                             
      Ependymoma Malignant                                                                    1 (1%)                                
      Granular Cell Tumor Benign                       1 (1%)                                                                       
   Spinal Cord                                        (1)          (2)                       (1)                                    
      Glioma Benign                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (52)         (51)         (70)                                   
      Alveolar/Bronchiolar Adenoma                     1 (1%)       3 (6%)                                                          
      Alveolar/Bronchiolar Carcinoma                   2 (3%)                                 1 (1%)                                
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (1%)                                
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Neurofibrosarcoma, Metastatic, Uncertain                                                                                      
          Primary Site                                 1 (1%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (1%)                                                                       
   Nose                                               (70)         (51)         (51)         (70)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Fibrosarcoma                                                                            1 (100%)                              
      Squamous Cell Papilloma, Multiple                             1 (100%)                                                        
   Zymbal's Gland                                     (2)          (1)          (1)                                                 
      Adenoma                                                                    1 (100%)                                           
      Carcinoma                                        2 (100%)     1 (100%)                                                        
                                                             Page  10                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (69)         (70)         (70)                                   
      Lipoma                                                        1 (1%)                                                          
      Renal Tubule, Adenoma                            1 (1%)       2 (3%)                    1 (1%)                                
      Renal Tubule, Oncocytoma Benign                               1 (1%)       1 (1%)                                             
   Urinary Bladder                                    (70)         (51)         (51)         (70)                                   
      Transitional Epithelium, Papilloma               1 (1%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(70)        *(70)        *(70)                                   
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leukemia Mononuclear                            32 (46%)     31 (44%)     30 (43%)     25 (36%)                               
      Mesothelioma Malignant                           2 (3%)       2 (3%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05085-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            54          50          50          54                                       
     Total Primary Neoplasms                          148         143         141         118                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 53          48          49          49                                       
     Total Benign Neoplasms                            97         100         101          83                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          38          34          31                                       
     Total Malignant Neoplasms                         51          43          40          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           2           4                                       
     Total Metastatic Neoplasm                          2           2           2           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.