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TDMS Study 05085-01 Pathology Tables

NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97
Route: DOSED FEED                                                                                                 Time: 17:39:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|             
                                           | 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                 X  X     X  X  X  X     X              X  X     X     X|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X     X                                   X         |             
      Hyperplasia                          |                                                 3                        |             
      Inflammation, Chronic                |    2  1           1           2  2              3        1  1     2     1|             
      Leukocytosis                         | X                                                                        |             
      Necrosis, Coagulative                |                                        1     3                           |             
      Thrombosis                           |                                                 X                        |             
      Vacuolization Cytoplasmic            | 1  1        3  4     1                 1                       4  1      |             
      Bile Duct, Cyst                      |                                                          X               |             
      Bile Duct, Hyperplasia               | 1  1        1  3     1  2        1     1  1     2  1     1     3  2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |                      3  1     1  1  2  1  2  1           1  2     2      |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Atrophy                      |                2                                2                       1|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                2         |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |             2                                                            |             
      Inflammation, Chronic Active         |                4                                               2         |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|             
                                           | 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +        +  +     +  +     +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  1        2  1     1  2        1        1     1  3     2        2     1|             
      Degeneration, Chronic                |          1                                                               |             
      Atrium, Thrombosis                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1  1        1  1     1           3           1  2           1  2  1      |             
      Hematocyst                           |    X                                                                     |             
      Hyperplasia                          |                2     2        2  1        1     2           1  2  2      |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1              2              1  2  2        1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |       X     X  X  X     X     X           X        X     X  X  X        X|             
      Pars Distalis, Hyperplasia           |                2                          2     2        2              2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2        2        1        1     2              2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                       3|             
      Inflammation, Chronic Active         |             2     1        1                                1            |             
      Duct, Ectasia                        |                4                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X              X            |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                      +   |             
      Dilatation                           |                                                                      4   |             
      Inflammation, Acute                  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Glandular       |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|             
                                           | 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                          |             
      Endometrium, Hyperplasia             |                                           3                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | M  M        +  +     +  +     +  M  +  M  +  M  +  +     +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                             X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                               X                                          |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  4        2  3  1  2  2  1  2  2  2  2  2  2  2        2  2  2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +        +  +     +  +     +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X  X                                                                     |             
      Hydrocephalus                        |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                      1  1           1     1     1                       1|             
      Inflammation, Chronic Active         | 3                    1                       4  1                        |             
      Metaplasia, Osseous                  |                                     1                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|             
                                           | 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                               X                                          |             
      Inflammation, Chronic Active         |                         2     3     3                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    1        4           1  2     3  2           1              1  1     4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |             3                                                            |             
      Nephropathy, Chronic                 | 1  2  1  1     2  1  3  1  1  3  1  1  1  2  3  1  2     1  2     3     1|             
      Thrombosis                           |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|             
                                           | 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                             X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X  X  X  X|             
      Clear Cell Focus                     |                                              X     X                 X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2     2     1     1     1  1     2     1  1     1  1           2  2  1  1|             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |                                                       1                  |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                2  1                                   3     1            |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |    1        1           1        1  1  1  1     1  2  2           1  1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                        +|             
      Inflammation, Necrotizing            |                3                                                        4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |    2  1           1     1        1  2  1  1        1  3     2     2  1   |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Atrophy                      |       1           1     2                          1                     |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       3                  |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|             
                                           | 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +     +  +  +  +  +        +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |       2     1     2  1  2        1  1  1  1     2     1     2     1  2  2|             
      Degeneration, Chronic                |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                2  2     2        1     1  1     2     2              1   |             
      Hematocyst                           |                                                                          |             
      Hyperplasia                          |    2           2  2                       2     2  1  1           2  2  1|             
      Hypertrophy                          |                2        2                       2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                 1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | X  X  X  X  X  X  X  X  X     X  X     X  X  X  X  X  X     X  X     X   |             
      Pars Distalis, Hyperplasia           |    2              2     3        2     3        3  2  3     2        2   |             
      Pars Intermedia, Cyst                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1        2        1        2  2  2        1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                              4      |             
      Inflammation, Chronic Active         |    2        1  1        1     1  2        3        2              3      |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                    X     X        X                                 |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Glandular       |                                           2     3                    2   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|             
                                           | 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                            2                                             |             
      Endometrium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
      Inflammation, Suppurative            |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +     +  +  +  +  +        +  +  +  +     +  +  +     +     +  +  M|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |             X                                                            |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2  3     1     3  4  3  1     2  4  2  2  1  1     2     3  1  2  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +  +     +  +  +  +  +        +  +  +  +     +  +  +     +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  1        1  1  1  1        1  1  1  1     1           1     1  1  1|             
      Inflammation, Chronic Active         |             1                                   1  1                     |             
      Metaplasia, Osseous                  |                1                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|             
                                           | 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2        2           2           2              2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +           +                 +                        |             
      Lens, Cataract                       |                   4           4                 4                        |             
      Retina, Atrophy                      |                   4           4                 4                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy, Chronic                 |    2  2  1  1  2  3  1  2  1  1  2  2  1  2  1  2  3  2     2  1  1  2  1|             
      Thrombosis                           |                   X                                                      |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                 1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6|              |            |
                             DAY ON TEST   | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9|              |            |
                                           | 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basophilic Focus                     | X  X        X        X  X  X     X     X     X  X        X               |     45     |
      Clear Cell Focus                     |                            X     X                                       |      5     |
      Hematopoietic Cell Proliferation     |                                                 2                        |      1  2.0|
      Hepatodiaphragmatic Nodule           |                            X           X                 X               |      7     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2        1        1  1  1     1           2  2        2               |     34  1.4|
      Leukocytosis                         |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      3  1.7|
      Thrombosis                           |                                                                          |      1     |
      Vacuolization Cytoplasmic            |             2                 2     3              3                     |     16  2.1|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    2        1           1  1  2  2  2           1  2                     |     36  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Inflammation, Necrotizing            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infiltration Cellular, Lipocyte      |             2           1  2  1  1  1  1     1  2        1               |     34  1.4|
      Acinus, Amyloid Deposition           |                                                          1               |      1  1.0|
      Acinus, Atrophy                      | 1                             2                    1                     |     10  1.4|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acanthosis                           |                                     2              3                     |      4  2.5|
      Hyperkeratosis                       |                                                    2                     |      1  2.0|
      Inflammation, Chronic Active         |                                     3              4                     |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6|              |            |
                             DAY ON TEST   | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9|              |            |
                                           | 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |             2                                                            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +        +        +  +  +  +  +  +  +     +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +        +        +  +  +  +  +  +  +     +  +  +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Cardiomyopathy, Chronic              |    2        2        1  1  2     2           1  1  2     2               |     38  1.5|
      Degeneration, Chronic                |                                           1                              |      2  1.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Degeneration, Fatty                  |    1        4           3     2        1           2     1               |     27  1.6|
      Hematocyst                           |                                                                          |      1     |
      Hyperplasia                          |    2                 4     1     2     2                 1               |     25  1.8|
      Hypertrophy                          |    2        3                                                            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |    1        1                       1        2                           |     12  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +               |  62        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Craniopharyngeal Duct, Cyst          |                                                    X                     |      1     |
      Pars Distalis, Angiectasis           | 2                                                                        |      1  2.0|
      Pars Distalis, Cyst                  |             X        X              X        X     X                     |     37     |
      Pars Distalis, Hyperplasia           |    2           2     2  2  3           3        2  2                     |     23  2.3|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      C-Cell, Hyperplasia                  |                         2  1     2     1                                 |     17  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperplasia                          |    2                                                                     |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6|              |            |
                             DAY ON TEST   | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9|              |            |
                                           | 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 1  3                 1     2  3  2     1        2                        |     21  1.7|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia, Cystic, Glandular       |                                                                          |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +        +        +  +  +  +  +  M  +     +  +  +     M               |  41        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Femoral, Myelofibrosis               |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                        X                                 |      4     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hematopoietic Cell Proliferation     |                                        2                                 |      2  2.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  64        |
      Cyst                                 |                                                                          |      2     |
      Ectopic Parathyroid Gland            |                               X                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Hyperplasia, Cystic                  | 1  3        3        2  2  2  2  2  3  2     2  2  2     4               |     53  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6|              |            |
                             DAY ON TEST   | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9|              |            |
                                           | 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
     0 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +        +        +  +  +  +  +  +  +     +  +  +     +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Compression                          |             X                                            X               |      4     |
      Hydrocephalus                        |             3                                            3               |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Infiltration Cellular, Histiocyte    |                      1  1  1     1           1  1                        |     27  1.0|
      Inflammation, Chronic Active         |                                                          2               |      8  1.8|
      Metaplasia, Osseous                  |                                  1                       1               |      4  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             3                 1                    1     1               |     19  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Lens, Cataract                       |                                                                          |      3  4.0|
      Retina, Atrophy                      |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +        +        +  +  +  +  +  +  +     +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 1  3        3        2  1  3  1  2  1  3     1  1  1     1               |     58  1.7|
      Thrombosis                           |                                                                          |      1     |
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|             
                             DAY ON TEST   | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|             
                                           | 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Chronic Active         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Basophilic Focus                     |    X           X  X  X           X     X  X  X  X  X     X     X  X      |             
      Clear Cell Focus                     |                                                          X              X|             
      Degeneration, Cystic                 |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X           X                                X              X         |             
      Inflammation, Chronic                | 1              1  2              2     2     2  2  1     2     1  1     2|             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            | 1                 1                                         4     1      |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2              1  1                          1  1        1  2     1     2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                       +|             
      Inflammation, Necrotizing            | 3                                                                       4|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +  +  +           +     +  +  +  +  +     +  A  +  +     +|             
      Infiltration Cellular, Lipocyte      |                   1              1     2     2  1  1     2     2  1     1|             
      Inflammation, Chronic Active         |                                           2                              |             
      Acinus, Atrophy                      | 4  3           2                       1  1                             1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Acanthosis                           | 2                                                           4            |             
      Hyperkeratosis                       |                                                             3            |             
      Inflammation, Chronic Active         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Erosion                              |             2                                                            |             
      Inflammation, Chronic Active         | 4                                                                        |             
      Mineralization                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Chronic Active         | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +           +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|             
                             DAY ON TEST   | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|             
                                           | 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Cardiomyopathy, Chronic              |             1  1     1           2     2     1     1     1        1     1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Degeneration, Fatty                  |                1                 1           1  2        1  2           2|             
      Hyperplasia                          |                1                 1                             2  1      |             
      Hypertrophy                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Hyperplasia                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +  +  +           +     +  +  +  +  +     +  A  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +        M  M  +  M           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Pars Distalis, Cyst                  |    X        X  X                       X  X  X     X     X  X     X     X|             
      Pars Distalis, Hyperplasia           | 2              3                 1     3     3  2        2              1|             
      Pars Intermedia, Hyperplasia         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      C-Cell, Hyperplasia                  | 1                 1              2                                2     2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +        +  +  +  +           +     +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                        4           3                     |             
      Inflammation, Chronic Active         |    1        1                    2              2     2  2               |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +  +  +  +           +     +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              | 3                                                                        |             
      Cyst                                 |                      X                       X  X     X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic, Glandular       |                                                                         3|             
      Inflammation, Chronic Active         |                                                                          |             
      Intussusception                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +           +  +  +  M           +     +  +  +  +  +     +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|             
                             DAY ON TEST   | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|             
                                           | 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Deep Cervical, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Inguinal, Cyst                       |                                                                          |             
      Lumbar, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |             3                             2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        +  +  +  M           +     +  +  +  +  +     +  +  +  +     +|             
      Cyst                                 |                                                    X        X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        M  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Hyperplasia, Cystic                  | 2  2           2  2  2           1     3  3  4  2  2     2  2  3  3     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +           +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Compression                          |                   X                                                      |             
      Hydrocephalus                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Infiltration Cellular, Histiocyte    |             1  1  1                    1     1  1  1     1     1  1      |             
      Inflammation, Chronic Active         |    1                                                           1  1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
      Fungus                               |                                                 X                        |             
      Inflammation, Chronic Active         |                                                 4                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    3                 2                       2     3           2        2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                           A            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|             
                             DAY ON TEST   | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|             
                                           | 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       | 4                                                                        |             
      Retina, Atrophy                      | 4                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +           +     +  +  +  +  +  +  +  +  +  +     +|             
      Nephropathy, Chronic                 | 2  1  1     1  2  2  1           2     2  1  1  1  2  1  2  1  2  2     1|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +  +  +           +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X     X     X        X        X     X  X  X     X     X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Inflammation, Chronic                | 1  2  1  1  2  1  1     2     1                 3     1  2  2     2  2   |             
      Necrosis, Coagulative                |                               1                                   2      |             
      Vacuolization Cytoplasmic            |                1  1                 3        3  3                    2   |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |       1  1     1  1           1     2        2        2     2     1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Inflammation, Necrotizing            |                               4                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Infiltration Cellular, Lipocyte      | 1     1  1     1              2        1              1     1     1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |       1                       1        1     1        1     1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Acanthosis                           |                                              4                       2   |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                     2                    2           3   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Cardiomyopathy, Chronic              |       2  1  1     1     2           2  1        1     1     2     1  1  1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Degeneration, Fatty                  |    1           1  2     1           2        1           1  1     1  1   |             
      Hyperplasia                          | 2  1  2        1  2     1     2        2                    2     1     1|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Hyperplasia                          |    1           1        2           2        1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Pars Distalis, Cyst                  | X        X     X  X     X                    X              X        X  X|             
      Pars Distalis, Hyperplasia           |          2     2  2           2        2     2                          2|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  |                         2           2                             2     2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Hyperplasia                          | 2                                      2                                 |             
      Inflammation, Chronic Active         | 1     2                             3                                   1|             
      Duct, Ectasia                        |                                     4                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +     +  +  +  +     +  +     +  +  +     +  +  +|             
      Atrophy                              |                                     3                             3      |             
      Cyst                                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic, Glandular       | 2                                                           4     3      |             
      Inflammation, Chronic Active         |             4                                                            |             
      Intussusception                      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis               |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Deep Cervical, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Inguinal, Cyst                       |                                                                          |             
      Lumbar, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +     +     M  +     +  +     +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Hyperplasia, Cystic                  | 3  4  3  2  3  2  2     3     2     4        4  1     4  3  1     3  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Compression                          | X  X                                                     X           X   |             
      Hydrocephalus                        |    2                                                     3           2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1  1           1        1     1        1  1  1     1     1|             
      Inflammation, Chronic Active         |    1                                   1                          1      |             
      Alveolar Epithelium, Hyperplasia     | 2                                   2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2  1           2                    2        2  4               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation, Chronic Active |          2                                                               |             
      Lens, Cataract                       |          3                                                               |             
      Retina, Atrophy                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  3  1  1  1  1  1     2     1  1  1  2     1  1     2  1  1  1  3  2  1|             
      Renal Tubule, Hyperplasia            |             2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +     +     +  +     +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6|              |            |
                                           | 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Parasite Metazoan                    |                                                          X               |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Inflammation, Chronic Active         |                   4                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +        +  +  +  +  +     +  +  +               |  54        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X              X  X           X  X               |     42     |
      Clear Cell Focus                     |       X                                                                  |      3     |
      Degeneration, Cystic                 | 2                                1                                       |      2  1.5|
      Hepatodiaphragmatic Nodule           |                X                 X  X     X                              |      9     |
      Inflammation, Chronic                |    1     1  2  2  1  1                 1  2                              |     35  1.5|
      Necrosis, Coagulative                |                         2                                                |      3  1.7|
      Vacuolization Cytoplasmic            |          2              2        3                 4  1                  |     15  2.1|
      Bile Duct, Cyst                      | X                                                                        |      1     |
      Bile Duct, Hyperplasia               | 1     1  1  2  1  1  1  2        2        3        2                     |     31  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   4        |
      Inflammation, Necrotizing            |                                                                          |      3  3.7|
      Necrosis                             |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  50        |
      Infiltration Cellular, Lipocyte      | 1  1  1  1  1     1  1           1     1              1                  |     31  1.2|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                  1        1           1  1               |     16  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Acanthosis                           |                                                    3                     |      5  3.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                    3                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  2.8|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                      +                                                   |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6|              |            |
                                           | 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Inflammation, Chronic Active         |                                  4                                       |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Cardiomyopathy, Chronic              | 2     1     1  1  1     2                 2           2  2               |     32  1.3|
      Atrium, Thrombosis                   |                                           X                              |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Degeneration, Fatty                  |          1              1        1        2        3     1               |     23  1.3|
      Hyperplasia                          | 1        2        2  2  2              2  2        3                     |     23  1.7|
      Hypertrophy                          |                                                          1               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Hyperplasia                          | 2                    2  2        2        2                              |     11  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  50        |
      Hyperplasia                          |                                           2                              |      1  2.0|
      Vacuolization Cytoplasmic            |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +        +     +  M        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Pars Distalis, Cyst                  |    X        X  X     X  X        X     X           X     X               |     29     |
      Pars Distalis, Hyperplasia           | 2     2        2     2  2        2        2        2     2               |     24  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      C-Cell, Hyperplasia                  |                                  2                    1  2               |     12  1.8|
      Follicular Cell, Hyperplasia         |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +        +     +  +        +  +  M               |  51        |
      Hyperplasia                          |                                                                          |      4  2.8|
      Inflammation, Chronic Active         | 2           2                          2           2  2                  |     15  1.8|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  53        |
      Atrophy                              |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6|              |            |
                                           | 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                   X                                   X                  |      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Dilatation                           |                                                       4                  |      1  4.0|
      Hyperplasia, Cystic, Glandular       |                                                                          |      4  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Intussusception                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Deep Cervical, Inflammation, Chronic |                                                                          |            |
          Active                           |                                  2                                       |      1  2.0|
      Inguinal, Cyst                       |    X                                                                     |      1     |
      Lumbar, Cyst                         |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  49        |
      Cyst                                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  50        |
      Hyperplasia, Cystic                  | 4  3  3  4  3  2  4  4  3        4     2  2        2  3  3               |     49  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Compression                          |          X                                            X                  |      7     |
      Hydrocephalus                        |          3                                            2                  |      6  2.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6|              |            |
                                           | 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1        1  1           1     1  1           1  1               |     35  1.0|
      Inflammation, Chronic Active         |    1           1                                                         |      8  1.0|
      Alveolar Epithelium, Hyperplasia     |    2                 1                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic Active         |                                           2                              |      2  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         2        1                 1                     |     15  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                          |      2  3.5|
      Retina, Atrophy                      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +               |  59        |
      Nephropathy, Chronic                 | 3  1  2  2  2  1  1  1  1  1  1  1  1  2  2     1  1  2  1               |     59  1.4|
      Renal Tubule, Hyperplasia            |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +        +     +  +        +  +  +               |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 7| 7| 2| 4| 7| 7| 7| 5| 4| 2| 7| 2| 4| 7| 7| 7| 2| 7| 2| 2| 6|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 7| 3| 2| 2| 2| 7| 3| 7| 2| 7| 3| 2| 2| 3| 7| 3| 7| 7| 8|             
                                           | 9| 9| 8| 9| 9| 9| 6| 7| 9| 9| 9| 1| 7| 5| 9| 6| 7| 9| 9| 0| 6| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +        +  +  +  +        +        +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +        +  +  +  +        +        +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Basophilic Focus                     |          X     X                 X                 X           X        X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 1                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Hyperplasia                          | 4                                                                        |             
      Inflammation, Chronic                |       1  1  2  1           3  1  1                 1  2  2     1        2|             
      Necrosis, Coagulative                |             1                                                            |             
      Vacuolization Cytoplasmic            | 3  4  2  1                                                     1         |             
      Bile Duct, Hyperplasia               | 2  3        1  1        1  1                       1  1  2     1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +        +                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Necrosis                             |                                     4                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Infiltration Cellular, Lipocyte      | 2        1  1  1           1  1  1        1           1        1         |             
      Acinus, Atrophy                      | 2           1                                      1           2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Acanthosis                           |       2                                                                  |             
      Hyperkeratosis                       |       2                                                                  |             
      Inflammation, Chronic Active         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Cardiomyopathy, Chronic              | 2        1  2           1  1  1                    3  2  2     2        2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 7| 7| 2| 4| 7| 7| 7| 5| 4| 2| 7| 2| 4| 7| 7| 7| 2| 7| 2| 2| 6|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 7| 3| 2| 2| 2| 7| 3| 7| 2| 7| 3| 2| 2| 3| 7| 3| 7| 7| 8|             
                                           | 9| 9| 8| 9| 9| 9| 6| 7| 9| 9| 9| 1| 7| 5| 9| 6| 7| 9| 9| 0| 6| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Degeneration, Fatty                  | 1  2        2  3        2  3  2           2        1                     |             
      Hyperplasia                          | 3           2           1     2                    1  1                  |             
      Hypertrophy                          |                3           2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Hyperplasia                          | 1  2     1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +        +  +  +  +        M        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  | X  X                    X                 X                              |             
      Pars Distalis, Hyperplasia           | 3  2                    3        2        2           2  2     2         |             
      Pars Intermedia, Cyst                |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      C-Cell, Hyperplasia                  | 1           2                                            1              2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M        M  +  +  M        +        +  +  +     +        +|             
      Hyperplasia                          |                                                    2                     |             
      Inflammation, Chronic Active         |                                                                1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +        +  +  +  +  +     +        +  +  +     +        +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                4                                                         |             
      Hyperplasia, Cystic, Glandular       |    3        1                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
      Inflammation, Suppurative            |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +        +  +  +  +        +        +  +  +     +        +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 7| 7| 2| 4| 7| 7| 7| 5| 4| 2| 7| 2| 4| 7| 7| 7| 2| 7| 2| 2| 6|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 7| 3| 2| 2| 2| 7| 3| 7| 2| 7| 3| 2| 2| 3| 7| 3| 7| 7| 8|             
                                           | 9| 9| 8| 9| 9| 9| 6| 7| 9| 9| 9| 1| 7| 5| 9| 6| 7| 9| 9| 0| 6| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Fibrosis                             |             2                                                            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +        +  +  +  +        M        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Hyperplasia, Cystic                  | 3  2     4  2  4        3  2  3  1        2        2  2  2     3        2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Infiltration Cellular, Histiocyte    | 1  1     1  1  1        1  1                       1  1                  |             
      Inflammation, Chronic Active         |          1                                         2     2     2         |             
      Alveolar Epithelium, Hyperplasia     |                               2                    3                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
      Fungus                               |       X                       X                                          |             
      Inflammation, Chronic Active         |       3                       3                       2                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                          2                                   2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +        M  +  +  +        +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +     +        +|             
      Nephropathy, Chronic                 | 1  1     3  3  1  1  1  3  3  3  2  1     2        1  2  2     3        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +        +  +  +  +        +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 2| 4| 7| 2| 0| 7| 6| 2| 7| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 7| 3| 3| 7| 4| 3| 6| 7| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 0| 7| 7| 5| 7| 0| 6| 5| 0| 6| 5| 0| 0| 5| 0| 0| 7| 0| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    5000 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +              +     M  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +           +  +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X           X  X        X        X  X     X  X     X  X     X  X  X  X|             
      Clear Cell Focus                     |                X                       X                          X      |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hepatodiaphragmatic Nodule           |                X           X  X                       X              X   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1              1           1        1        1        2        1  1     2|             
      Necrosis, Coagulative                |                                                                2         |             
      Vacuolization Cytoplasmic            |    1                          3        1        1        1     1        1|             
      Bile Duct, Hyperplasia               |    1              1        1  2              1  1     2     2     1  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Inflammation, Chronic Active         |                3                                                         |             
      Inflammation, Necrotizing            |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |                   1        1        2  1     1  1     1  1  1  2     1  2|             
      Acinus, Atrophy                      |                                              2                    1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                   4      |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2                       2  1     1  2     1  1        1        1  1  1|             
      Atrium, Thrombosis                   |                               X                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 2| 4| 7| 2| 0| 7| 6| 2| 7| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 7| 3| 3| 7| 4| 3| 6| 7| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 0| 7| 7| 5| 7| 0| 6| 5| 0| 6| 5| 0| 0| 5| 0| 0| 7| 0| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    5000 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    1              2        2  1     1  1        2                 2  1   |             
      Hyperplasia                          |    2              2        2  2     2  2        2        1     2  2  2   |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +              +     +  +  +     +  +     +  +     +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                 X                        |             
      Pars Distalis, Cyst                  |                   X        X  X     X        X        X        X     X   |             
      Pars Distalis, Hyperplasia           |                   2                          2        3        3     2   |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +              +     A  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                   2     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +              +     +  +  +     +  +     +  +     +  M  +  +  +  +  +|             
      Hyperplasia                          |                                     2  3              4           3      |             
      Inflammation, Chronic Active         | 1  2                          2                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                               4                                          |             
      Cyst                                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +           +  +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Cystic, Glandular       |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | M  +              +     M  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 2| 4| 7| 2| 0| 7| 6| 2| 7| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 7| 3| 3| 7| 4| 3| 6| 7| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 0| 7| 7| 5| 7| 0| 6| 5| 0| 6| 5| 0| 0| 5| 0| 0| 7| 0| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    5000 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Fibrosis                             |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M              +     +  +  +     +  +     +  +     +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3              2        3  4     3  4     2  2     3  3  2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1              1           1     1           1     1  1  1     1     1|             
      Inflammation, Chronic Active         |                                     1  1                 1     1         |             
      Alveolar Epithelium, Hyperplasia     |                                              1                          2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                                              1                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                          2  1                       2           2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Lens, Cataract                       |                                                                   4      |             
      Retina, Atrophy                      |                                                                   4      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  1  1     1  1        1  1     1  3  1  2  2  1  1  2  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +              +     +  +  +     +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|              |            |
                                           | 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
      Parasite Metazoan                    |                      X     X                                             |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  52        |
      Basophilic Focus                     |    X  X  X  X  X  X     X  X  X  X     X  X  X  X     X                  |     36     |
      Clear Cell Focus                     |                                        X                                 |      4     |
      Degeneration, Cystic                 |                   2        2                                             |      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic                |       2  1  1  2  1        1  2  2              2     1                  |     31  1.4|
      Necrosis, Coagulative                |                   1                                                      |      3  1.3|
      Vacuolization Cytoplasmic            | 4           1  1        2                 1  1                           |     18  1.7|
      Bile Duct, Hyperplasia               | 2  1  1  1  1        2  1  1  1        1  1  1        1  2               |     35  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   5        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Necrotizing            |                            3                                             |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
      Infiltration Cellular, Lipocyte      |    1  1  1        1  1  1  1  1  1     1  1  2  2     1                  |     36  1.2|
      Acinus, Atrophy                      | 1           1  1  1  4           2                       3               |     13  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
      Acanthosis                           |                2        2                                                |      4  2.5|
      Hyperkeratosis                       |                         2                                                |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Inflammation, Chronic Active         |       3        3                                                         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|              |            |
                                           | 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Cardiomyopathy, Chronic              | 2        1     2  1  1  2  2  1        1     2  2     1                  |     34  1.5|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Degeneration, Fatty                  | 1        2  2     1  2           1     3     1        2  2               |     28  1.7|
      Hyperplasia                          |          2  2  2           1           2        2     2                  |     24  1.8|
      Hypertrophy                          |                                                          2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Hyperplasia                          |                                                 2     1                  |      6  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  M  M     +  +  +  +     +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Craniopharyngeal Duct, Cyst          |                                        X                                 |      2     |
      Pars Distalis, Cyst                  | X     X     X     X  X     X  X  X           X        X  X               |     23     |
      Pars Distalis, Hyperplasia           | 2  2  2     3  3  2  3     2  2              2        2                  |     24  2.3|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
      C-Cell, Hyperplasia                  |          2                 1  1                                          |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  47        |
      Hyperplasia                          |             2        2  2  3           2                                 |     10  2.5|
      Inflammation, Chronic Active         |             2  1  4           1              1  4     2  2               |     12  1.9|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                         X                       X                        |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  53        |
      Dilatation                           |       3                                3                                 |      2  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Cystic, Glandular       |    2           2        2     2        2                                 |      8  2.0|
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|              |            |
                                           | 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
      Cyst                                 |                      X                          X                        |      2     |
      Hyperplasia, Plasma Cell             |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +     +  +               |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Hyperplasia, Cystic                  | 2  1  3  3  2  2  2  3  3  4  3  2     3  3  3  3     3  2               |     49  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Compression                          |                      X                                                   |      1     |
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Infiltration Cellular, Histiocyte    |    1  1     1  1  1  1  1     1  1        1  1  1     1                  |     32  1.0|
      Inflammation, Chronic Active         |                                                                          |      8  1.4|
      Alveolar Epithelium, Hyperplasia     |             2                                2                           |      6  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
      Fungus                               |                                                                          |      2     |
      Inflammation, Chronic Active         | 2                    2                                                   |      6  2.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|              |            |
                                           | 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    5000 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |       2  1  2  2                 2              2        2               |     16  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  61        |
      Nephropathy, Chronic                 | 1  1  1  2  1  2  2  1  2  1  2  1  1  1  3  2  2  1  2  1               |     59  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +               |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|             
                                           | 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Basophilic Focus                     |       X  X  X     X           X  X  X  X  X  X     X     X  X  X     X  X|             
      Clear Cell Focus                     |          X                                   X                           |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2                                            2         |             
      Hepatodiaphragmatic Nodule           |       X                                      X                           |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |       1  1  2  1                 1     2  3              2  2  2  2  2  1|             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |    2        2     1                                      1        1      |             
      Bile Duct, Hyperplasia               |    2           1  1                    1  1        1  1  1  1  2  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |                   2           1        1  1        1     1  1  1     1   |             
      Acinus, Atrophy                      |       1                             1     2     1     3                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       2                  |             
      Hyperkeratosis                       |                                                       3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +  +  +           +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               2        2                       3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|             
                                           | 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +        +  +  +           +        +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    1        2  2  1           1  1        1              2  1     2  1  2|             
      Degeneration, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                   1                                2  1     1  2  1      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                   2                       1                    2        1|             
      Hypertrophy                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                             X            |             
      Pars Distalis, Congestion            |                         3                                                |             
      Pars Distalis, Cyst                  |    X                                                     X     X        X|             
      Pars Distalis, Hyperplasia           |                2        2                                2  2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                                1        1           2        1|             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
      Inflammation, Chronic Active         |    2           2  3              1        1        3     4     2        2|             
      Duct, Cyst                           |                      X                                                   |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                     2                                    |             
      Hyperplasia, Cystic, Glandular       |                               2           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|             
                                           | 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +        +  +  +           +        +  +        +  +  +  +  +  +  +  +|             
      Polycythemia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Erythrocyte    |                                                                          |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             2     2                                                      |             
      Lymphoid Follicle, Hyperplasia       |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  1  1  3  2  2           3  1  1  2  2  3     3     2  2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic Active         |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +        +  +  +           +        +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        X                                 |             
      Hydrocephalus                        |                                        3                             2   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Histiocyte    |                1                       1  1        1        1  1  1     1|             
      Inflammation, Chronic Active         |                               2                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   2                       2                 2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|             
                                           | 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               |                                                                      X   |             
      Inflammation, Chronic Active         |                   1                                                  3   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2  2     2  2        2              3     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  +  +           +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy, Chronic                 |    1  1  1  2  3  3  1        2  2  1  2  2  1     2  1  2  2  1  3  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Hemorrhagic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|             
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|             
                                           | 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                                 |             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |          X                                                               |             
      Basophilic Focus                     | X  X  X        X  X  X  X        X  X     X  X  X  X        X  X         |             
      Clear Cell Focus                     |       X           X  X                                                   |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
      Hepatodiaphragmatic Nodule           |          X                                                           X   |             
      Hyperplasia                          |                                        3                                 |             
      Inflammation, Chronic                | 1  2  2  2     1  1  3  1        2  1     2  1  2     1        1  1      |             
      Leukocytosis                         |          X                                                               |             
      Necrosis, Coagulative                |          3                                                        2      |             
      Vacuolization Cytoplasmic            | 1     1        3     1                 3           1                 2   |             
      Bile Duct, Hyperplasia               |    1  1           1  2           1  2  3  1        1  2     1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +     +                  |             
      Inflammation, Necrotizing            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |    1           1     2  1        1  2     1                          1   |             
      Acinus, Atrophy                      |                   3  2                 2                 1  1            |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2  2                    2                                            2   |             
      Hyperkeratosis                       |                                                                      3   |             
      Inflammation, Chronic Active         |                                                                      3   |             
      Perforation                          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|             
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|             
                                           | 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +  +  +        +  +  +  +     +  +  +     +     +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2     2  1     2        2  1  2  2     2  2        1        1   |             
      Degeneration, Chronic                |                               3                                         1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |       1  1     2        1              1  1     1  2  1           2  3   |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia                          |    2  1        2                 2  2              2        1        2   |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                         X                                                |             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  | X              X  X              X  X  X  X  X  X     X        X  X      |             
      Pars Distalis, Hyperplasia           | 2              2  2              2  2     2  3              1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2        3        2  1  1              1           2              2      |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Hyperplasia                          |       3           2                                         2            |             
      Inflammation, Chronic Active         | 1     2           2              2        3     2  1           1     2   |             
      Duct, Cyst                           |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic, Glandular       |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|             
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|             
                                           | 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +     +  +  +  +        +  +  +  +     +  +  +     +     +  +   |             
      Polycythemia                         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Erythrocyte    |                                                                   3      |             
      Femoral, Myelofibrosis               |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X                 X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                         2                                         4      |             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  3  3     3  3  3  2        2  3  4  4  1  3  2  4        1  3  3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +     +  +  +  +        +  +  +  +     +  +  +     +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    X                     |             
      Hydrocephalus                        |                                                    2                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |          X                                                               |             
      Infiltration Cellular, Histiocyte    | 1  1              1  1           1  1           1           1     1  1   |             
      Inflammation, Chronic Active         |    1     1                                                        2      |             
      Leukocytosis                         |          X                                                               |             
      Necrosis, Coagulative                |                                        4                                 |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|             
                             DAY ON TEST   | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|             
                                           | 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    15000                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               | X                                                                        |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 1              2  2  2  3                 2                 2     2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                              +      |             
      Lens, Cataract                       |    4                                                              4      |             
      Retina, Atrophy                      |    4                                                              4      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic Active         |                                              2                           |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |          X                                                               |             
      Hydronephrosis                       |          2                                                               |             
      Inflammation, Chronic Active         |          3                                                               |             
      Nephropathy, Chronic                 | 1  2  3  2     1  2  2  1  1     1  2  1  2  1  1  3  1     1  1  1  3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Hemorrhagic            |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3|              |            |
                                           | 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Bacterium                            |                                                                          |      1     |
      Basophilic Focus                     | X  X  X  X     X  X  X     X  X  X     X     X  X  X     X               |     46     |
      Clear Cell Focus                     |                   X                             X                        |      7     |
      Degeneration, Cystic                 |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     |                               3                                          |      4  2.5|
      Hepatodiaphragmatic Nodule           | X        X           X                             X                     |      8     |
      Hyperplasia                          |                                                       3                  |      2  3.0|
      Inflammation, Chronic                | 2  1  2  2        1  1     2  2  1     1     2  2  1     2               |     43  1.6|
      Leukocytosis                         |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |       1  1              2                 3           2                  |     17  1.6|
      Bile Duct, Hyperplasia               |       1                 3     2  2           1  1  1  3  1               |     33  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Infiltration Cellular, Lipocyte      | 1  1     2        1        1              1  1  1  1     1               |     27  1.1|
      Acinus, Atrophy                      |          2        2              2           1                           |     14  1.7|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Acanthosis                           |                         2                 2                              |      7  2.0|
      Hyperkeratosis                       |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                         2                 2                              |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3|              |            |
                                           | 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Perforation                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +               |  58        |
      Inflammation, Chronic Active         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +        +     +  +  +  +        +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Cardiomyopathy, Chronic              | 2  2  2  2        2        2  2  1           1     2     1               |     38  1.6|
      Degeneration, Chronic                |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Degeneration, Fatty                  | 1  2  1  1                 1     1        1  1  1  1                     |     27  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          | 3  2  2  1                 2                 2     1     1               |     20  1.7|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  M  M  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Craniopharyngeal Duct, Cyst          |                                                                          |      2     |
      Pars Distalis, Congestion            |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  | X  X  X  X        X     X     X        X     X  X  X  X                  |     28     |
      Pars Distalis, Hyperplasia           |    2     3        2        2  2              2        3  2               |     20  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      C-Cell, Hyperplasia                  |       1  1                 2           1     1  2                        |     19  1.5|
      Follicular Cell, Cyst                |    X                                                                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  63        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3|              |            |
                                           | 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                  2                       3               |      6  2.3|
      Inflammation, Chronic Active         |          2     1                          1        1     2               |     23  1.9|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Ectasia                        |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Atrophy                              |                                           3                              |      1  3.0|
      Cyst                                 |                                                    X                     |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia, Cystic, Glandular       |                                  1           3                           |      5  2.2|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +        +     +  +  +  +        +  +  +  +  +  +               |  48        |
      Polycythemia                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Femoral, Hyperplasia, Erythrocyte    |                                                                          |      1  3.0|
      Femoral, Myelofibrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Cyst                                 |       X                                                                  |      3     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  66        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  M  +  M  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Hyperplasia, Cystic                  | 2  2  2  2     3  2  1  3  3  2  3     1  4  2  4  3  2  2               |     56  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +        +     +  +  +  +        +  +  +  +  +  +               |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3|              |            |
                                           | 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    15000                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Compression                          |                                           X                              |      3     |
      Hydrocephalus                        |                                  2        3                              |      5  2.4|
      Necrosis                             |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Bacterium                            |                                                                          |      1     |
      Infiltration Cellular, Histiocyte    |    1  1  1        1     1  1  1  2           1  1        1               |     29  1.0|
      Inflammation, Chronic Active         | 1     1  1                       2        1                              |      9  1.3|
      Leukocytosis                         |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Fungus                               |                X  X                                                      |      4     |
      Inflammation, Chronic Active         |                4  3                                                      |      5  2.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                       2                 3  2        2  2               |     21  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                       +                                             |   4        |
      Lens, Cataract                       |    4                       4                                             |      4  4.0|
      Retina, Atrophy                      |    4                                                                     |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +               |  58        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Bacterium                            |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 1  2  3  3     1  3  1  1  1  2  2     1  3  2  2  2  1  1               |     60  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Inflammation, Hemorrhagic            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|             
                                           | 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X                                       |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |       2  2              1  2           1  1           1           1      |             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    1        1     2  1  1  2     1        2           1  2        1      |             
      Necrosis, Coagulative                |    2                                                                     |             
      Vacuolization Cytoplasmic            |                         1        1        1     2              1  1      |             
      Bile Duct, Hyperplasia               |    2  2  3  1     2  1  3  2     1     2  3  3  3     3  3  3  2  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                      +  +                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Inflammation, Necrotizing            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X        X      |             
      Infiltration Cellular, Lipocyte      |             1                             1                              |             
      Acinus, Atrophy                      | 1  1  1  2     3  2                    2  1     1           1  2  2     1|             
      Acinus, Hyperplasia                  |                                                                   2      |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                   3              3     2                          2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Hyperplasia        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             2     2  2                       2  2     2  3  3     2      |             
      Hyperkeratosis                       |                   2  2                                                   |             
      Inflammation, Chronic Active         |                      3                       4  4           3            |             
      Mineralization                       |                                                                   4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1           2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|             
                                           | 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                            4           2     2        3           4      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                         +                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +     +  +  +  +     +     +  +  +  +     +  +  +  +  +      |             
      Mineralization                       |                            3                                      4      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  2  3  2  2  3     2     3  2  3  1  2  2  2  2     4     2|             
      Degeneration, Chronic                |                               2     2                                3   |             
      Mineralization                       |                            2                                      3      |             
      Atrium, Thrombosis                   |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         X                                                |             
      Degeneration, Fatty                  |          1  1     2  4  1  2     1     1  2  3  1     1  1     2  2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                   2  2     2           2              1        1  2      |             
      Hypertrophy                          |                                           2                              |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2        2  2  3        2     2  2  2  2     3  1  1  2  3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2           2     3           3              3           3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                X     X                             X              X     X|             
      Pars Distalis, Hyperplasia           |       2     2     2  2           3              2     2  2               |             
      Pars Distalis, Hypertrophy           |                2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       3                 2        3        1              1        2      |             
      Follicle, Cyst Multilocular          |                                                                          |             
      Follicular Cell, Mineralization      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|             
                                           | 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Chronic                |                                                                      2   |             
      Inflammation, Chronic Active         | 1  2  3  2        1  2  2     2  2     2  2  2  2     4     3     2     2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         | 1  2           1     2  2        2           4  1     3  2        3      |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2                    2     2     2  1     2     2     1     1      |             
      Interstitial Cell, Hyperplasia       |             1  1  1  2     1        2              2        1           1|             
      Seminiferous Tubule, Atrophy         |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +  +  +     +  M  +  M     +     +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                 X     X                                                |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       1  2  1  1  1  2  2        3     1  1  4  2  1  2  2  3  2  2     1|             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              2                           |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                              4                           |             
      Ulcer                                |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|             
                                           | 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |                      X     X           X              X           X      |             
      Femur, Fibrous Osteodystrophy        |                      X     X           X              X           X      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +  +  +  +     +  +  +  +     +     +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                X         |             
      Hydrocephalus                        |                                                                3         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       1     1              1     1                    1        1         |             
      Inflammation, Chronic Active         |                   1  1     2                                             |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                            1                                      2      |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2        1                 1                    2     1  2        1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 2  1  3  3  2  2  3  4  3  4  2  3  1  4  2  4  2  1  4  4  2  2  4  1  1|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|             
                                           | 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   2      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                     X              X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X        X                                X                     |             
      Clear Cell Focus                     | X                                                                       X|             
      Degeneration, Cystic                 |                      1  1  1                                            2|             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Chronic                | 2  1                 1  3  2  2        1           1     1        2      |             
      Necrosis, Coagulative                |                         1                 2                    2         |             
      Vacuolization Cytoplasmic            | 1     1                    2                 1           1  3  2        1|             
      Bile Duct, Hyperplasia               | 2  2  3  2           2  3  2  2        3     3     3     1  3  3  2     3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                       +                        |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                        1     2     1     1  1  1  1  1   |             
      Acinus, Atrophy                      |    1     2                                1     3        1  1  2        4|             
      Acinus, Hyperplasia                  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                              2                    4      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                               +                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Hyperplasia        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3              2  2                             4     2        2|             
      Hyperkeratosis                       |                                                          2               |             
      Inflammation, Chronic Active         |          3                                               4  2           2|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|             
                                           | 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +     +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +           +  +  +  +        +     +     +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2     2     2  3  2  2        2  2  2  2  2     2  2     3     3|             
      Degeneration, Chronic                |             2     2              1  2                                    |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |       X                 X                                   X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |       2                 1  2           2     2           2  2     1  1  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2  2           2     2           2     2           2        2      |             
      Hypertrophy                          |       2                                      2                           |             
      Necrosis, Coagulative                |                                                                         2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     2                 3     2        1     2                 2        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                  2     3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                         X|             
      Pars Distalis, Hyperplasia           |                      2        3     2  2        1              3  2      |             
      Pars Distalis, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        2           2     2           2     2  2  2        1  1         |             
      Follicle, Cyst Multilocular          |                                        X                                 |             
      Follicular Cell, Mineralization      |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|             
                                           | 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2  2  2  2           1  2  3  2  2  1  2  2  2     2     1  1  3  2     2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Inflammation, Chronic Active         |    2  1  1              2  3  1        1     3  2     2  3  2  1  2      |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1  1  1              2  2  1                                   1     2|             
      Interstitial Cell, Hyperplasia       |                1                       2  1     1              1         |             
      Seminiferous Tubule, Atrophy         |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +           +  +  +  +        +     +     +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Plasma Cell             |                2                                                     3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  M  M  +  M  +|             
      Hyperplasia, Cystic                  | 1  2     1     1     1  3  3  1              3     2     3              1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            4                                             |             
      Hyperkeratosis                       |                            4                                             |             
      Inflammation, Chronic Active         |                            2                                             |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|             
                                           | 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |          X                                                        X      |             
      Femur, Fibrous Osteodystrophy        |          X                                                        X      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +           +  +  +  +        +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            X                                             |             
      Hydrocephalus                        |                            3                                             |             
      Necrosis                             |                                                                4         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |          1           1     1                       1                     |             
      Inflammation, Chronic Active         |                                                          1               |             
      Metaplasia, Osseous                  |          1                                                               |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                         X|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                X        X                                                |             
      Inflammation, Chronic Active         | 2     3        3        3                                            3   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2  1           2                             1                    1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                2         |             
      Retina, Atrophy                      |                                                                4         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +     +     +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 3  3  3  4  1  2  1  3  3  3  3  1  1  3  2  3  2  3     3  2  2  4     4|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          2               |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3|              |            |
                                           | 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basophilic Focus                     |    X           X                 X        X  X                           |     12     |
      Clear Cell Focus                     |                               X                                          |      3     |
      Degeneration, Cystic                 |             2           2     2  2                                       |     16  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia                          |       4                                                                  |      2  3.5|
      Inflammation, Chronic                |       2                 1  1  1              1                           |     26  1.4|
      Necrosis, Coagulative                |                                                                          |      4  1.8|
      Vacuolization Cytoplasmic            |          3  2     1     1  1  1           1        2     1               |     23  1.4|
      Bile Duct, Hyperplasia               |    2  3  3  3        2  2  1  2  3  2     2  2        2  2               |     48  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +           +                                          |   8        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Necrotizing            |          4                    3                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      2     |
      Infiltration Cellular, Lipocyte      |    1  1           1           1  1  1     1  2     1     1               |     20  1.1|
      Acinus, Atrophy                      |    1  1        1        1              2                                 |     26  1.6|
      Acinus, Hyperplasia                  |    3                                                                     |      2  2.5|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Sublingual Gland, Hyperplasia        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acanthosis                           |          2  3           3                             3                  |     19  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3|              |            |
                                           | 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      3  2.0|
      Inflammation, Chronic Active         |          3              2                             2                  |     11  2.9|
      Mineralization                       |                            3                                             |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                         2                             3                  |      4  2.0|
      Mineralization                       |                      3     3                                             |      8  2.9|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +               |  61        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +               |  52        |
      Mineralization                       |                      3     4                                             |      4  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cardiomyopathy, Chronic              | 2  1     3  2  2  2  3  2  3  3  2  2  2  3  2     2  2  3               |     57  2.2|
      Degeneration, Chronic                |                                                 2                        |      8  2.0|
      Mineralization                       |                      2     3                                             |      4  2.5|
      Atrium, Thrombosis                   |          X                                                               |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Degeneration, Fatty                  |       1     1           2        2           1     2  2  2               |     33  1.6|
      Hematopoietic Cell Proliferation     |                   1                                                      |      1  1.0|
      Hyperplasia                          |             2  1        1                    2     2     2               |     21  1.8|
      Hypertrophy                          |                                  2                                       |      4  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |          1  2              2  2  2                       1               |     28  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hyperplasia                          |                      2  2  3              2  3                           |     14  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Pars Distalis, Cyst                  |    X                          X                                          |      8     |
      Pars Distalis, Hyperplasia           |       2        1        1  2           1                 3               |     21  2.0|
      Pars Distalis, Hypertrophy           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      C-Cell, Hyperplasia                  |                         3                    1     1                     |     19  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3|              |            |
                                           | 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst Multilocular          |                                                                          |      1     |
      Follicular Cell, Mineralization      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                  +                                       |   1        |
      Inflammation, Chronic Active         |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |                                              2                           |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1  2  2  1  2     1     2  2  2  2  2  1  2  2        2  2               |     52  1.9|
      Duct, Ectasia                        |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |    3  2  3  2     1  2  2  3  1  2  2     2  1        1  2               |     40  2.0|
      Mineralization                       |                   2                                                      |      1  2.0|
      Epithelium, Hyperplasia              |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mineralization                       |             2           1  2  1     1     2              1               |     25  1.5|
      Interstitial Cell, Hyperplasia       | 1           1  1  2                    1              1                  |     20  1.3|
      Seminiferous Tubule, Atrophy         |                                                       4                  |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +  +  M  +     +  M  +  M  +  +  +     +  +     +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Cyst                                 |    X                                X                                    |      5     |
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fibrosis                             |                         3     3                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |                   3                                2                     |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3|              |            |
                                           | 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lipocyte      |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Ectopic Parathyroid Gland            |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  58        |
      Hyperplasia, Cystic                  | 1        2  3  1        2     2  1  1  2  1  2        4  3               |     44  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Acanthosis                           |                                                                          |      2  3.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cranium, Fibrous Osteodystrophy      |                      X  X  X              X  X                           |     12     |
      Femur, Fibrous Osteodystrophy        |                      X  X  X              X  X                           |     12     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +               |  52        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Compression                          |             X                                         X                  |      4     |
      Hydrocephalus                        |             2                                         4                  |      4  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infiltration Cellular, Histiocyte    |                                                       1  1               |     12  1.0|
      Inflammation, Chronic Active         |                         4                                                |      5  1.8|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                            2                       1                     |      4  1.5|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                            3                 2                           |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fungus                               |                                                                          |      2     |
      Inflammation, Chronic Active         |                         2                                                |      7  2.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3|              |            |
                                           | 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |          2  1        4     2        1                    1               |     18  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   3        |
      Cornea, Inflammation, Chronic Active |                         2                                                |      1  2.0|
      Cornea, Mineralization               |                         1                                                |      1  1.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +               |  62        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hydronephrosis                       |                                  3                                       |      1  3.0|
      Nephropathy, Chronic                 | 1  4  3  2  3  2  1  4  4  4  2  3  2  1  4  4  2  2  4  3               |     68  2.6|
      Renal Tubule, Hyperplasia            |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                  3                                       |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|             
                             DAY ON TEST   | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|             
                                           | 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Mineralization                       |                                  3                                       |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                        X                                 |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +     +        +  M  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +     +|             
      Basophilic Focus                     |             X              X                                             |             
      Clear Cell Focus                     |                            X                                             |             
      Degeneration, Cystic                 |    1  3              2           1              1  2                    1|             
      Hepatodiaphragmatic Nodule           |    X  X                    X                                             |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |          1  1              2  1     1     2     1     1     1     2     2|             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |                3              2  3                                       |             
      Vacuolization Cytoplasmic            |       2     2        3           2        1  3                           |             
      Bile Duct, Hyperplasia               |    3  2  3  2  2     4        2  2  1  2  1  3  2  2  2     2     3     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Inflammation, Necrotizing            |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +        A  +  +  +  +  +  +  +  +     +     +     +|             
      Ectopic Tissue                       |                                                                          |             
      Infiltration Cellular, Lipocyte      |             1                       1     3                              |             
      Acinus, Atrophy                      |    2  1  1     2     2                 1                                2|             
      Acinus, Hyperplasia                  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  M  +  +  +     +        +  M  +  +  +  M  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +     +     +     +|             
      Acanthosis                           |                                        3  3  2  3  2        3           2|             
      Diverticulum                         |                         2                                                |             
      Hyperkeratosis                       |                                        3        2                        |             
      Inflammation, Chronic Active         |                                        3     4  4           4            |             
      Mineralization                       |                                  2                                      2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|             
                             DAY ON TEST   | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|             
                                           | 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                               1                                          |             
      Inflammation, Chronic Active         |                      2              3     3     3                        |             
      Mineralization                       |                               1  3  1  2           3                    4|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +  +     +        +  M  +  +  +  +  +  +  +     +     +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                  4                 3                    4|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Cardiomyopathy, Chronic              |    2  2  2  2  2     2        2  3  3  2  2  2  2  3  2     2     2     4|             
      Mineralization                       |                                  3                                      3|             
      Atrium, Thrombosis                   |                X     X                                                   |             
      Valve, Inflammation, Chronic Active  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Degeneration, Fatty                  |                2                    2  2  3  3  2     2     3     1      |             
      Hyperplasia                          |       2              2              2                       1           1|             
      Hypertrophy                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Hyperplasia                          |    2  1  1     2     1              2     3                       3     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +        A  +  +  +  +  +  +  +  +     +     +     +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +     +        M  M  +  +  +  M  +  +  +     +     +     +|             
      Hyperplasia                          |                                     3  3        2  3                    3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +     +        +  M  +  +  +  +  +  +  +     +     +     +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  |                      X                                            X     X|             
      Pars Distalis, Hyperplasia           |    2                 2                                1                  |             
      Pars Intermedia, Cyst                |       X                                                                  |             
      Pars Nervosa, Cyst                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +     +        +  M  +  +  +  M  +  +  +     +     +     +|             
      C-Cell, Hyperplasia                  |                                                       2           1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |    +                                   +                    +            |             
      Inflammation, Chronic Active         |                                        3                    4            |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|             
                             DAY ON TEST   | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|             
                                           | 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Hyperplasia                          |                                        3                                 |             
      Inflammation, Chronic Active         |    2  2  2  4        2        1  2  1  2  1  2  2  2  2     2     2     2|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |    2  2        2     2           2  2  3     2  3  3  1     4     1     1|             
      Mineralization                       |                                                                         1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Mineralization                       |             2  1     1           1  2  1        1  2        1           2|             
      Interstitial Cell, Hyperplasia       |          1           1                    2        2  1                 1|             
      Seminiferous Tubule, Atrophy         |    4                                               4                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +  +  +  +     +        M  M  +  +  +  M  +  M  +     +     +     +|             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Femoral, Myelofibrosis               |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M  +  +  +     +        +  M  +  +  +  M  +  +  +     +     +     +|             
      Cyst                                 |                                        X                    X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Fibrosis                             |                      3                       3                    2      |             
      Hematopoietic Cell Proliferation     |                3                                                         |             
      Infiltration Cellular, Lipocyte      |       2                                                                  |             
      Necrosis, Coagulative                |                               4                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  M     +     +     +|             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +     +        M  +  M  +  +  M  +  M  M     +     M     +|             
      Hyperplasia, Cystic                  |    2  1  1  2  2     2           1     3  2     4           4           2|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Acanthosis                           |                                                       3                  |             
      Alopecia                             |                                                       X                  |             
      Cyst Epithelial Inclusion            |                                        X                                 |             
      Inflammation, Chronic Active         |                                           4           3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Cranium, Fibrous Osteodystrophy      |                                     X  X        X  X                    X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|             
                             DAY ON TEST   | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|             
                                           | 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                  X  X  X        X  X                    X|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +     +        +  M  +  +  +  +  +  +  +     +     +     +|             
      Compression                          |                                           X                 X            |             
      Hydrocephalus                        |                                           3                 2            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                     +                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
      White Matter, Degeneration           |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Infiltration Cellular, Histiocyte    |    1        1        1              1  1  1                              |             
      Inflammation, Chronic Active         |                2                 3                    3                 3|             
      Leukocytosis                         |                                                                          |             
      Metaplasia, Osseous                  |                                  1                                       |             
      Mineralization                       |                                  3                                      3|             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     1                                    |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                             3            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +     +        +  M  +  +  +  +  +  +  +     +     +     +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          1  2  1                    1        1  1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Cornea, Inflammation, Chronic Active |                                     4                                    |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
      Inflammation, Chronic Active         |             2                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  3  2  2  3  2  1  2  1  3     4  4  4  3  2  4  4  2  2  4  1  3  2  4|             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|             
                             DAY ON TEST   | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|             
                                           | 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Hyperplasia            |    2                                                                     |             
      Renal Tubule, Hyperplasia, Oncocytic |                                           2                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|             
                             DAY ON TEST   | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|             
                                           | 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1500 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     M  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |       X              X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Inflammation, Chronic Active         |                                                                      3   |             
      Parasite Metazoan                    |       X                                                                  |             
      Thrombosis                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Basophilic Focus                     |       X     X                 X                                          |             
      Clear Cell Focus                     |                         X                                            X   |             
      Degeneration, Cystic                 |             2        1        1     1           2                    2  1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                         4|             
      Inflammation, Chronic                |    1        2     1  1  1     1     1  1     1              2  2         |             
      Leukocytosis                         |    X                                                        X            |             
      Necrosis, Coagulative                |                                                             3            |             
      Vacuolization Cytoplasmic            | 2  3              2     2     1        2  3  2  3                    3  2|             
      Bile Duct, Hyperplasia               | 3  1  2     2     2  2  2     2  3  2  2  3  2  2           2  1     4  4|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +     +     +  +                                   +   |             
      Inflammation, Necrotizing            |             4     3     4     3                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Ectopic Tissue                       |                                                                      X   |             
      Infiltration Cellular, Lipocyte      |             1     1     1           1        1                           |             
      Acinus, Atrophy                      |       1     1     2  2              3  1  2  1              1  2        2|             
      Acinus, Hyperplasia                  |                                                 2                        |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                              3  4                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Acanthosis                           |    3                             2     4                                 |             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |    3                                                                     |             
      Inflammation, Chronic Active         |    2                             4     3                                 |             
      Mineralization                       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|             
                             DAY ON TEST   | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|             
                                           | 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1500 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                           2                              |             
      Inflammation, Chronic Active         |    3                                                                 3   |             
      Mineralization                       |                      3        3                 3                        |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Inflammation, Chronic Active         |                                                 3                        |             
      Mineralization                       |                      4        4                 4                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Cardiomyopathy, Chronic              | 2  2  3           2  3  2     3  2  1  2     2  3           3  1     2  2|             
      Mineralization                       |                      2        2                                      2   |             
      Atrium, Thrombosis                   |                                                                      X   |             
      Valve, Inflammation, Chronic Active  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Degeneration, Fatty                  | 1  2        1        1  1        3     2  3                 1  1        2|             
      Hyperplasia                          |    2        2           1              2                                 |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Hyperplasia                          | 1           2     1     2              1     1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Hyperplasia                          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     +  +  +     +  +  +  +  +  +  +           M  +     +  +|             
      Hyperplasia                          |                      4        4                 3                    2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |       2              2              2     2  3  2           2  1         |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      C-Cell, Hyperplasia                  |    2              1                 1  2     2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|             
                             DAY ON TEST   | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|             
                                           | 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1500 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +     +     +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2  2  2     2     2  2  2     2  2  2  2  2  2  2     3     2  2     2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         | 2  2        3     1  2  2     2  1     3  2  3  2           2  1     2  3|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +  +           +  +     +  +|             
      Mineralization                       | 2  1  1           1  1  1        2  1     2     3                    2  2|             
      Interstitial Cell, Hyperplasia       |             1     1  2                 2                                 |             
      Seminiferous Tubule, Atrophy         |                      3                 3                             4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +     +     +  M  +     +  +  +  +  +  +  +           M  +     M  +|             
      Leukocytosis                         |    X                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Cyst                                 |    X              X     X                                               X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  M  +     +  +  +  +  +  +  +           +  +     +  +|             
      Inflammation, Chronic Active         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Fibrosis                             |                                  2                                   2   |             
      Hematopoietic Cell Proliferation     |                                                 2           2            |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     +     +  M  +     +  +  +  +  +  +  +           +  +     +  +|             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +     +  M  +     +  +  +  +  M  +  +           M  +     M  +|             
      Hyperplasia, Cystic                  | 2  4  2     4     3     2     1  2  2  4     2  1              2        2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Acanthosis                           |                                                                          |             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                      4                 4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Cranium, Fibrous Osteodystrophy      |                      X        X                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|             
                             DAY ON TEST   | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|             
                                           | 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1500 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                      X        X                 X                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Compression                          |    X                                   X                                 |             
      Hydrocephalus                        |    2                                   2                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Infiltration Cellular, Histiocyte    |    1  1     1           1     1     1  1     1  1                       1|             
      Inflammation, Chronic Active         |                      2        2        1                             2   |             
      Leukocytosis                         |                                                             X            |             
      Metaplasia, Osseous                  |                                                                      1   |             
      Mineralization                       |                      2        3                                          |             
      Thrombosis                           |                                                                      X   |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Fungus                               |                                           X                             X|             
      Inflammation, Chronic Active         |                      1           2     3  3                             3|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 1  2              1  1        1        1        2              2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       |             4                                                            |             
      Retina, Atrophy                      |             4                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +     +  +  +     +  +  +  +  +  +  +           +  +     +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  3  3  1  3  1  3  4  3  2  4  2  3  3  2  3  4  1  2  2  3     1  3  3|             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|             
                             DAY ON TEST   | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|             
                                           | 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1500 PPM                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  M  +     +  +  +  +  +  +  +           +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2|              |            |
                             DAY ON TEST   | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7|              |            |
                                           | 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |    X              X                                                      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Parasite Metazoan                    |             X                                                            |      3     |
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  53        |
      Basophilic Focus                     |             X        X                             X  X                  |      9     |
      Clear Cell Focus                     |                      X                                X                  |      5     |
      Degeneration, Cystic                 |                         2     3  2  1              1                     |     19  1.6|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Hyperplasia                          |                               3                                          |      2  3.5|
      Inflammation, Chronic                |    1  1  1     1     1     1                 1        1                  |     30  1.2|
      Leukocytosis                         |                                                                          |      2     |
      Necrosis, Coagulative                |                                                                          |      4  2.8|
      Vacuolization Cytoplasmic            |    1                 2  1     1  1                 1                     |     23  2.0|
      Bile Duct, Hyperplasia               |    2  2     2  2     2  2  2  3  3  3        1  3  1  1                  |     50  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                +                                    |   9        |
      Inflammation, Necrotizing            |                                                                          |      6  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
      Ectopic Tissue                       |                                                                          |      1     |
      Infiltration Cellular, Lipocyte      |       2     1  1     1                                1                  |     13  1.2|
      Acinus, Atrophy                      |       2     1  2     1  2  3  2  2           2        1                  |     28  1.7|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  54        |
      Acanthosis                           |                         3           2                                    |     12  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2|              |            |
                             DAY ON TEST   | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7|              |            |
                                           | 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Diverticulum                         |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      3  2.7|
      Inflammation, Chronic Active         |                         4                                                |      8  3.5|
      Mineralization                       |                            3                                             |      4  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Erosion                              |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                         3                    2                           |      8  2.8|
      Mineralization                       |    3     3                 3                       3                     |     13  2.7|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +  +  +  +  +     +  +  +  +  +  +        +  +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +  +     +  +  +  +  +  +        +  +  +  +                  |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |    4     4                 4                       4                     |     10  3.9|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Cardiomyopathy, Chronic              |    3  2  2  2  2     2  3  3     2  2        1  2  3  2                  |     48  2.2|
      Mineralization                       |    1                       2                       1                     |      8  2.0|
      Atrium, Thrombosis                   |                                  X                    X                  |      5     |
      Valve, Inflammation, Chronic Active  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Degeneration, Fatty                  |                1        2  3  1     3        2        2                  |     27  1.9|
      Hyperplasia                          |                         2     2  2           2        2                  |     14  1.8|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Hyperplasia                          |    1                    2  2  2              2  1  2  2                  |     23  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  47        |
      Hyperplasia                          |    3                    2  3                       3                     |     14  2.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  M  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  50        |
      Craniopharyngeal Duct, Cyst          |             X                                                            |      1     |
      Pars Distalis, Cyst                  |    X                             X                 X                     |      7     |
      Pars Distalis, Hyperplasia           |             2  1                             1     2                     |     15  1.8|
      Pars Intermedia, Cyst                |                                  X                                       |      2     |
      Pars Nervosa, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  M  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2|              |            |
                             DAY ON TEST   | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7|              |            |
                                           | 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                1     1           2           1        2                  |     12  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  53        |
      Hyperplasia                          |       3     4                                                            |      3  3.3|
      Inflammation, Chronic Active         |    2  2     2  2     2  2  2  2  2  2        1  2  2  2                  |     50  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Cyst                                 |                         X  X                                             |      2     |
      Inflammation, Chronic Active         |    2  2                 2  1     1           2     1  3                  |     38  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +                  |  54        |
      Mineralization                       |    1        1           2  2  1  1  1              1  1                  |     31  1.4|
      Interstitial Cell, Hyperplasia       |       2                    1  1              1  2                        |     15  1.4|
      Seminiferous Tubule, Atrophy         |                                                                          |      5  3.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    M  +  +  +  +     +  +  +  +  +  +        +  M  +  +                  |  42        |
      Leukocytosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Femoral, Myelofibrosis               |                                     2                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Renal, Hyperplasia, Plasma Cell      |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  48        |
      Cyst                                 |                                     X                                    |      7     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Fibrosis                             |                         3                                                |      6  2.5|
      Hematopoietic Cell Proliferation     |    2                                                                     |      4  2.3|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2|              |            |
                             DAY ON TEST   | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7|              |            |
                                           | 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  M  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  48        |
      Ectopic Parathyroid Gland            |                            X                                             |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  M  M  M        +  +  +  +                  |  39        |
      Hyperplasia, Cystic                  |    1  1  2  1  1     1  2  2                 2  2  1  2                  |     38  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Acanthosis                           |                                                                          |      1  3.0|
      Alopecia                             |                                                                          |      1     |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Cranium, Fibrous Osteodystrophy      |    X     X              X  X                       X                     |     13     |
      Femur, Fibrous Osteodystrophy        |    X     X              X  X                       X                     |     14     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +  +  +  +  +     +  +  +  +  +  +        +  +  +  +                  |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
      Compression                          |                                                                          |      4     |
      Hydrocephalus                        |                                                       2                  |      5  2.2|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                           |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                              +                           |   2        |
      White Matter, Degeneration           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
      Infiltration Cellular, Histiocyte    |       1                                            1                     |     18  1.0|
      Inflammation, Chronic Active         |                            3                                             |      9  2.3|
      Leukocytosis                         |                                                                          |      1     |
      Metaplasia, Osseous                  |                               2     1                                    |      4  1.3|
      Mineralization                       |    2                       3                                             |      6  2.7|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      3  1.7|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
      Fungus                               |       X     X                                                            |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2|              |            |
                             DAY ON TEST   | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7|              |            |
                                           | 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    1500 PPM                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |       3     3              2                                             |      9  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                     1                 1                  |     16  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +  +  +     +  +  +  +  +  +        +  +  +  +                  |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Nephropathy, Chronic                 | 2  4  2  4  3  3  1  3  4  4  3  3  2  1  2  1  2  4  3  1               |     68  2.6|
      Glomerulus, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |          2           3                                                   |      3  2.3|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +                  |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|             
                             DAY ON TEST   | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|             
                                           | 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +     +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X              X     X                              |             
      Clear Cell Focus                     |                                     X     X                              |             
      Degeneration, Cystic                 |          1                 1  1        1  1     1        2  1           2|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |       1  2     1     1  1  1     2  1              1                    1|             
      Leukocytosis                         |                                                             X            |             
      Necrosis, Coagulative                |                                                             2  4         |             
      Thrombosis                           |                                                                X         |             
      Vacuolization Cytoplasmic            |       1              1  2     1     1  1        1        2        2      |             
      Bile Duct, Hyperplasia               | 3     2  1     2     1  2  2  1  2  2  2  2     2  2  3  3  2  3  3  2  2|             
      Hepatocyte, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +  +        +        +|             
      Inflammation, Necrotizing            |                                                    4  3        4        4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      | 1                             1  1        1     1  1  1           1  1   |             
      Acinus, Atrophy                      |       2                 2  2                          2        2         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 3                             3  3                             2  2      |             
      Hyperkeratosis                       | 2                             2  2                                       |             
      Inflammation, Chronic Active         | 4                             2  4                                       |             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Erosion                              |                2                                                         |             
      Inflammation, Chronic Active         |                               2  3                    3           2      |             
      Mineralization                       |          4                 2     2     2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|             
                             DAY ON TEST   | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|             
                                           | 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |          4                 4                                             |             
      Thrombosis                           |                                                                         X|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2     2  3     2     2  3  3  3  3  2  2  3     3  3  2  3  3  3  3  1  2|             
      Mineralization                       |          1                 2                                             |             
      Atrium, Thrombosis                   |                                           X     X              X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 2     1  1     1        2     2  2     2  1        1  2  2  1  3  2     1|             
      Hyperplasia                          |          2                    1  2              1  1  1        1         |             
      Hypertrophy                          |                                     2                                    |             
      Necrosis, Coagulative                |                                                                   2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |       2  2     2           1     2  2  3  2     2  2  1     2  1  2     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                 3     3     2              1                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2        1     1        2                 2           2     2      |             
      Pars Intermedia, Cyst                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        1              1                          1     1        1      |             
      Follicle, Cyst Multilocular          |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|             
                             DAY ON TEST   | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|             
                                           | 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2     2  1     2     2  3  2  2  2  3  2  2     2  2  2  3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
      Inflammation, Chronic Active         | 2     2  2           1  3  1  2  2  3  1  2     2     3  2  1  1  1  4   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2                 2     3  1                 1        2  1     1|             
      Interstitial Cell, Hyperplasia       |          1                    1           2        1              2      |             
      Seminiferous Tubule, Atrophy         |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +     +  M     +     +  +  M  M  +  +  +  +     M  +  +  +  +  +  +  +  +|             
      Leukocytosis                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X     X                                    |             
      Hyperplasia, Plasma Cell             |                                  2        3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2                          2                  |             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M  +     +     +  M  M  +  +  +  +  +     +  +  +  +  +  +  M  +  M|             
      Hyperplasia, Cystic                  | 2        2     1     2        2  2  3  2  3     1  2  2  3  2  3     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                 X                        |             
      Inflammation, Chronic Active         |                            4                             4               |             
      Mineralization                       |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |          X                 X  X  X                                       |             
      Femur, Fibrous Osteodystrophy        |          X                 X  X  X                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|             
                             DAY ON TEST   | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|             
                                           | 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Compression                          |                         X                             X                  |             
      Hydrocephalus                        |                         2           2                 3                  |             
      Necrosis                             |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1              1                          1                              |             
      Inflammation, Chronic Active         | 2        3                 1              2                              |             
      Leukocytosis                         |                                                             X            |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |          3                 1                                             |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          4                 2        2              2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          3                 2        2     4     2  3           1  4      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +     +                                       |             
      Cornea, Inflammation, Chronic Active |          2                 1     2                                       |             
      Cornea, Mineralization               |          2                 1                                             |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                          4               |             
      Nephropathy, Chronic                 | 2  1  2  4  2  3  1  3  3  4  4  4  3  4  3  1  2  3  2  2  3  2  3  1  3|             
      Thrombosis                           |                                                          X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|             
                                           | 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                            X                 X  X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                                                     |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Basophilic Focus                     |          X                 X                                X     X  X   |             
      Clear Cell Focus                     |                                                                   X      |             
      Degeneration, Cystic                 |                      3                       2  1           1  2  1      |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Inflammation, Chronic                |    2     1              1  1              3     1           1           1|             
      Leukocytosis                         |                                                       X                  |             
      Necrosis, Coagulative                |                                                       3              1   |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |    1     1           2  1  1              2  4                    1  1   |             
      Bile Duct, Hyperplasia               |    2     2     1  3  2  2  2           2  2     2     2     2  3  2  2  1|             
      Hepatocyte, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Inflammation, Necrotizing            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |          1              1  2           1     1              1        2  1|             
      Acinus, Atrophy                      |                   2  2  2              1                    2  3  1  3  1|             
      Acinus, Hyperplasia                  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |    3     4                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Acanthosis                           |                                              2  2                       2|             
      Hyperkeratosis                       |                                              2                           |             
      Inflammation, Chronic Active         |                                              4  2                        |             
      Mineralization                       |                      3                    3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                              2                           |             
      Mineralization                       |    3                 3                    3     2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|             
                                           | 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                                                     |             
      Mineralization                       |    4                 4                    4                              |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    3     3     2  2  3  1  2           1  4  1  2     2     2  2  2  3  2|             
      Mineralization                       |    3                 2                    4                              |             
      Atrium, Thrombosis                   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Degeneration, Fatty                  |                   2     1  1           1  2  2  3              1  2     1|             
      Hyperplasia                          |    2                 1     1                    2                 3      |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |    2     2           2                    2     1                 1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +  +  +  M  +           +  +  +  +     +     +  +  +  +  M|             
      Hyperplasia                          |    3     3           3                    3     3                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  |                                                             X            |             
      Pars Distalis, Hyperplasia           |    1           2  3                             2                 1  1   |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     2                                                  1  1  2  1  2|             
      Follicle, Cyst Multilocular          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                           +                              |             
      Inflammation, Chronic Active         |                                           4                              |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|             
                                           | 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +     +  +  +  +  +        +  +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |    1     2     2  2  2  2  2           2  2  2  1     3     2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |    1     1     1     1  3  1           2  4  3  3     2     2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           3                              |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Mineralization                       |    1     2        2        2              2     1           1  1     1   |             
      Interstitial Cell, Hyperplasia       |                                                       1                 1|             
      Seminiferous Tubule, Atrophy         |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +     +  +  M  +  +           +  +  +  +     M     +  +  +  +  +|             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Hyperplasia, Plasma Cell             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Fibrosis                             |                3           4                                3        3   |             
      Hematopoietic Cell Proliferation     |    3                                      3                              |             
      Necrosis, Coagulative                |                4                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +  +  +  +  +           +  +  +  +     M     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     M     +  M  M  +  +           +  +  +  M     M     +  +  +  +  M|             
      Hyperplasia, Cystic                  |    2           2        2  2           1  4  4              3  3  2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +     +  +  +  +  +           +  +  +  M     +     +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |    X     X           X                    X     X                        |             
      Femur, Fibrous Osteodystrophy        |    X     X           X                    X     X                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|             
                                           | 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Compression                          |                         X                 X  X              X            |             
      Hydrocephalus                        |                         2                 2  2              2            |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                1           1                                1            |             
      Inflammation, Chronic Active         |    3     3           3                    2                              |             
      Leukocytosis                         |                                                       X                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |    3                 4                    2                              |             
      Alveolar Epithelium, Hyperplasia     |    3                                                                    2|             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                            1                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          3     2  2  1                       2        2        1         |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +                                         +            |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |    2                                                                     |             
      Lens, Cataract                       |                   4                                         4            |             
      Retina, Atrophy                      |                   4                                         4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy, Chronic                 | 1  4  1  4  1  3  3  4  3  3  1  2  2  2  4  3  4  2  2  2  3  3  3  3  2|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +  +  +  +  +           +  +  +  +     +     +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7|              |            |
                             DAY ON TEST   | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3|              |            |
                                           | 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  +     +     +        +  +     +  +  +  +        +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  50        |
      Parasite Metazoan                    |                                              X                           |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Parasite Metazoan                    |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Lymphoid Tissue, Hyperplasia         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +     +        +  +     +  +  +  +     +  +  +               |  52        |
      Basophilic Focus                     |             X                                            X               |     10     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Cystic                 |                                        1  3  1           1               |     19  1.4|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic                |    2              2        2  1     1  1     1                           |     25  1.3|
      Leukocytosis                         |                                                                          |      2     |
      Necrosis, Coagulative                |                                                                          |      4  2.5|
      Thrombosis                           |                                                                          |      1     |
      Vacuolization Cytoplasmic            |       3     1                       1     3  2        3                  |     24  1.6|
      Bile Duct, Hyperplasia               | 2  1              3        3  2     1  3  3  2        3  2               |     48  2.1|
      Hepatocyte, Atrophy                  |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Inflammation, Necrotizing            |                                                                          |      5  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Infiltration Cellular, Lipocyte      |    1  1     1     1        1        1  1     1                           |     25  1.1|
      Acinus, Atrophy                      |                   3           1        1  1                              |     18  1.8|
      Acinus, Hyperplasia                  |       3                                                                  |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +     +        +  +     +  +  +  +        +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +     +        +  +     +  +  +  +        +  +               |  52        |
      Acanthosis                           |    3                                                  3  2               |     11  2.5|
      Hyperkeratosis                       |    3                                                  2                  |      6  2.2|
      Inflammation, Chronic Active         |    4  4                                               4                  |      8  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7|              |            |
                             DAY ON TEST   | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3|              |            |
                                           | 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +     +        +  +     +  +  +  +        +  +               |  52        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |       3                                   2           2                  |      8  2.4|
      Mineralization                       | 2                                                                        |      9  2.6|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       | 3                                                                        |      6  3.8|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Cardiomyopathy, Chronic              | 2  2  3     3     2        3  2     3  2  2  2        2  2               |     51  2.4|
      Mineralization                       |                                                                          |      5  2.4|
      Atrium, Thrombosis                   |                                           X                              |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Degeneration, Fatty                  |    1  2                    1  1           2           3                  |     32  1.6|
      Hyperplasia                          |    1                          1        1  2           2                  |     17  1.5|
      Hypertrophy                          |                               2                                          |      2  2.0|
      Necrosis, Coagulative                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Atrophy                              |                   4                                                      |      1  4.0|
      Hyperplasia                          | 2  1  1     1                 2     2  2  2           2  2               |     31  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Hyperplasia                          |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +     +        +  +     +  +  +  +        +  +               |  49        |
      Hyperplasia                          |    3  2                                                                  |     12  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Craniopharyngeal Duct, Cyst          |    X                                                                     |      1     |
      Pars Distalis, Cyst                  |       X                                                                  |      2     |
      Pars Distalis, Hyperplasia           |    2                          2        2  2  3                           |     18  1.8|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      C-Cell, Hyperplasia                  |       2                             1                                    |     15  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7|              |            |
                             DAY ON TEST   | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3|              |            |
                                           | 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst Multilocular          |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  52        |
      Inflammation, Chronic Active         | 2  1  2     2     2        2  2     1  2  2  2        2                  |     45  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |    1  3     2              3  2        1  3  1        2  2               |     44  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Mineralization                       | 1                                   1  1     1           1               |     22  1.4|
      Interstitial Cell, Hyperplasia       |    2                                1     1                              |     10  1.3|
      Seminiferous Tubule, Atrophy         |                                     2                                    |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +     +     +        M  +     +  +  +  +        +  +               |  44        |
      Leukocytosis                         |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Femoral, Atrophy                     |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Cyst                                 |                                                                          |      3     |
      Hyperplasia, Plasma Cell             |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Fibrosis                             |    2                                                                     |      7  2.7|
      Hematopoietic Cell Proliferation     |    2                                                                     |      4  2.8|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +     +     +        +  +     +  +  +  +        +  +               |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7|              |            |
                             DAY ON TEST   | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3|              |            |
                                           | 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +     +     M        +  M     +  +  M  +        +  +               |  36        |
      Hyperplasia, Cystic                  |    1  2     2              2        1  1     2        1  2               |     36  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +     +        +  +     +  +  +  +        +  +               |  50        |
      Alopecia                             |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                       2                  |      3  3.3|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Cranium, Fibrous Osteodystrophy      | X  X                                                                     |     11     |
      Femur, Fibrous Osteodystrophy        | X  X                                X                                    |     12     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Compression                          |       X                                                                  |      7     |
      Hydrocephalus                        |       3                                                                  |      8  2.3|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Infiltration Cellular, Histiocyte    |    1                                   1  1                              |      9  1.0|
      Inflammation, Chronic Active         |             3                                                            |      9  2.4|
      Leukocytosis                         |                                                                          |      2     |
      Metaplasia, Osseous                  |             1                             1                              |      2  1.0|
      Mineralization                       | 2                                                                        |      6  2.5|
      Alveolar Epithelium, Hyperplasia     |       2     1                                                            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Inflammation, Chronic Active         | 3                                         2                              |      7  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       2                                   1              2               |     18  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
      Cornea, Inflammation, Chronic Active |                                                                          |      3  1.7|
      Cornea, Mineralization               |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7|              |            |
                             DAY ON TEST   | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3|              |            |
                                           | 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    5000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lens, Cataract                       |                                                                          |      2  4.0|
      Retina, Atrophy                      |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 4  4  4  2  3  1  3  1  2  3  3  1  3  3  3  3  3  1  2  3               |     70  2.6|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +     +        +  +     +  +  +  +        +  +               |  51        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|             
                             DAY ON TEST   | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|             
                                           | 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          2               |             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                X                           |             
      Clear Cell Focus                     |                X              X                                          |             
      Degeneration, Cystic                 |    2  2        2              1                    1                     |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                4        4                                                |             
      Inflammation, Chronic                | 2           1     1     2  1  1                    1     2              1|             
      Necrosis, Coagulative                |                                                                2         |             
      Thrombosis                           |                         X                                                |             
      Vacuolization Cytoplasmic            |       1        2  1  4        1     1                                   2|             
      Bile Duct, Hyperplasia               | 3  3  3     2  3  2  2  3  2  1     2  3     2     2     2        3     1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                 +      |             
      Inflammation, Necrotizing            | 4                                                                 4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                     1                 1                 1|             
      Acinus, Atrophy                      |    2  1     2     1  1  1              1  1     1        1               |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2              2  2  3        2                    3                     |             
      Hyperkeratosis                       |                      2                             2                     |             
      Inflammation, Chronic Active         |                4  2  3                             3              3      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                                              2      |             
      Mineralization                       | 4                             2              2     2     3              4|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|             
                             DAY ON TEST   | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|             
                                           | 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Caries                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +  +     +  +     +     +  +  +        +     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 3                             2                          2              4|             
      Thrombosis                           |             X                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 3  1           3  1  1  2  2  3     2  2  2  2  2  2  2  3        2     3|             
      Degeneration, Chronic                |          1                       2                          2        2   |             
      Mineralization                       |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X                                                            |             
      Atypia Cellular                      |                                                                          |             
      Degeneration, Fatty                  |    2  1     2  2     3  2           1              2              2      |             
      Hyperplasia                          |    2  1     2  2        3           2        2                    2      |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1  2     2        1        2              2                          2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                            1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           2  2              3                    2     2              2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Mineralization                       |                                                                          |             
      Craniopharyngeal Duct, Cyst          |                                                    X                     |             
      Pars Distalis, Cyst                  |    X  X              X                    X                              |             
      Pars Distalis, Hyperplasia           |    2        3                 2     2  2                 1               |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1        1                 1     2                                    |             
      Follicle, Cyst Multilocular          |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |             +                                                            |             
      Inflammation, Chronic Active         |             4                                                            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|             
                             DAY ON TEST   | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|             
                                           | 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
      Inflammation, Chronic Active         | 3  2  2     2  2  1     2  2  2     2  2     2  3  2           2        2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2  2  2     2     2  2     2  3     2  1  1  3  2     1           3     1|             
      Thrombosis                           |             X                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             3            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1  1     1  1  1     1     1        1     1                           |             
      Necrosis, Coagulative                |             4                                                            |             
      Interstitial Cell, Hyperplasia       |          2     1     1  1                 1     1              2  2  2   |             
      Seminiferous Tubule, Atrophy         |                4                                         3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +     M  +  M  +  +  +  +     +  +     +     +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                3              3                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
      Ectopic Thyroid                      |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +  M  M|             
      Hyperplasia, Cystic                  | 1  1  2        2  2  2        1        2        2  2           3  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|             
                             DAY ON TEST   | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|             
                                           | 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      | X                             X                    X     X              X|             
      Femur, Fibrous Osteodystrophy        | X  X                          X                    X     X              X|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +     +  +  +  +  +  +  +     +  +     +     +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   X                                                      |             
      Hydrocephalus                        |                   4        2                                             |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 3                                                                        |             
      Infiltration Cellular, Histiocyte    |    1        1  1  1     1                                                |             
      Inflammation, Chronic Active         | 2                                            2                           |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 2                                                                        |             
      Thrombosis                           |                         X                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                      X                                                   |             
      Inflammation, Chronic Active         |       2              2                             2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    1           1  2                 1     2        1     1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +        +      |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                          3               |             
      Cornea, Mineralization               |                                                          2               |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  2  1  2  4  2  2  2  2  4  1  3  3  2  4  2  4     4  1  2  2  2  4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|             
                             DAY ON TEST   | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|             
                                           | 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                              3                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|             
                             DAY ON TEST   | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|             
                                           | 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     15000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X     X     X                          X            |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                              1                           |             
      Hepatodiaphragmatic Nodule           |    X                                                     X               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1  1     2  1           1  2     1  1        1     2     1  2     1      |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |    2              1     1        2  1        3  2        2               |             
      Bile Duct, Hyperplasia               |    1     2     2  2     2  2     1           2  2  2     1  2     2     3|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                         +  +                        |             
      Inflammation, Necrotizing            |    4                                         4  4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lipocyte      |          1  1  1           1                    1                    1   |             
      Acinus, Atrophy                      |                1           1              1     1        1  1           2|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2                    3                       2                        |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                         2                       2                        |             
      Mineralization                       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    4     4              3        2  3        3              2     2      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|             
                             DAY ON TEST   | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|             
                                           | 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     15000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Caries                               |                                                                      3   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +     +  +  +  +     +  +     +  +  +     +  +  +     +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    4     4              4        4  4        4              4            |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  3     3  3  2     2  3  3     3  3        3  2  3     2  3  1  2     2|             
      Degeneration, Chronic                |       2                                                                  |             
      Mineralization                       |          2              2        2  2        2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atypia Cellular                      |                                                                          |             
      Degeneration, Fatty                  |    2     2  1  1  1     2                    2           2  1     2  1  1|             
      Hyperplasia                          |    2        1           2                    2                          2|             
      Hypertrophy                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     3        2     2  2     2           2                    1     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3     3        2     3  3     2           3              3            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia           |                   3  2                                                   |             
      Pars Intermedia, Cyst                |                                           X  X                 X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst Multilocular          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|             
                             DAY ON TEST   | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|             
                                           | 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     15000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Chronic Active         |    1  2  2  1  2  2  1  1  2  2  2  2     2  2  2  2     1  2  1  1     2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       2                                                                  |             
      Inflammation, Chronic Active         |    2     1  2  2  3  2  2  2        2     2  2  2  3     2     2  3  1  2|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2              1        1  2        2     1        1            |             
      Necrosis, Coagulative                |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  2        1     2  1           1        2  2  2        1     1  1     2|             
      Seminiferous Tubule, Atrophy         |    4                             4              4        4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +  +  +  +     +  +     +  M  M     M  +  M     +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectopic Thyroid                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M|             
      Hyperplasia, Cystic                  |    2     2        2  1  2        1  2     1  2  3  3        2     2  1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                              4                           |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|             
                             DAY ON TEST   | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|             
                                           | 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     15000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |    X     X              X  X     X  X        X              X            |             
      Femur, Fibrous Osteodystrophy        |    X     X              X  X     X  X        X              X            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +     +  +  +  +     +  +     +  +  +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                 X        X               |             
      Hydrocephalus                        |                                                 3        2               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |             +                                                            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
      White Matter, Degeneration           |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1              1                                      1               |             
      Inflammation, Chronic Active         |                                              2              2     3      |             
      Metaplasia, Osseous                  |                                              2     1                     |             
      Mineralization                       |                                     2        2              3            |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |          2                                                  2     2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2     2  1        2           1           1        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +        +     +                                         +      |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                   2      |             
      Cornea, Inflammation, Chronic Active |    2     2              2                                                |             
      Cornea, Mineralization               |    2     2              3                                         2      |             
      Lens, Cataract                       |                   3                                                      |             
      Retina, Atrophy                      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  4  2  4  3  2  3  2  4  4  2  4  4     2  4  2  4  1  3  4  2  3  1  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|             
                             DAY ON TEST   | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|             
                                           | 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     15000                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                         2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7|              |            |
                                           | 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basophilic Focus                     |       X                                   X  X                           |      9     |
      Clear Cell Focus                     |                                           X                              |      3     |
      Degeneration, Cystic                 |             2     2  1        1  2  1                                    |     12  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia                          |                                                                          |      2  4.0|
      Inflammation, Chronic                |       2     3     2  2     2  1              1  2  2                     |     31  1.5|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Vacuolization Cytoplasmic            |             1  2           1              1     1     3                  |     21  1.7|
      Bile Duct, Hyperplasia               | 2  2  2     2  2  2  2     2  3  2  3     2  2  2  2  3                  |     47  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   6        |
      Inflammation, Necrotizing            |                                                                          |      5  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Cyst                                 |                   X                                                      |      1     |
      Infiltration Cellular, Lipocyte      |       1        1                    1     1  1                           |     14  1.0|
      Acinus, Atrophy                      |    3              1           2  2        1                              |     22  1.3|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                      4                    4                              |      3  3.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acanthosis                           |                   2                          3                           |     11  2.4|
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                              3                           |      8  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7|              |            |
                                           | 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         | 1                                                     3                  |      4  2.3|
      Mineralization                       |       3     4  3  4  3     3     2           2  4                        |     23  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +                  |  59        |
      Caries                               |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +     +  +  +  +     +  +  +  +     +  +  +  +  +                  |  52        |
      Inflammation, Chronic Active         |                      3                                                   |      1  3.0|
      Mineralization                       |       2     4  4  4  4                          4                        |     17  3.6|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cardiomyopathy, Chronic              | 2  2  3     3  3  3  3     2  2     2  1  2  2  2  3  2                  |     52  2.3|
      Degeneration, Chronic                |                         1                                                |      6  1.7|
      Mineralization                       |       1           1                             1                        |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Atypia Cellular                      |                                        X                                 |      1     |
      Degeneration, Fatty                  |    1                 2     1  1              1  1  1                     |     28  1.5|
      Hyperplasia                          |             2        2        2     2     2                              |     18  1.9|
      Hypertrophy                          |                                           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          | 1  1        2     2  2        2  2  2           2     2                  |     27  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperplasia                          |                   2                                                      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  66        |
      Hyperplasia                          |       3     3  2  3  4     3  3              3                           |     23  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Mineralization                       |       1                                                                  |      1  1.0|
      Craniopharyngeal Duct, Cyst          |       X                                                                  |      2     |
      Pars Distalis, Cyst                  |                   X  X     X                                             |      8     |
      Pars Distalis, Hyperplasia           |                   2     2  2           2  2                              |     13  2.1|
      Pars Intermedia, Cyst                |    X                       X           X                                 |      6     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7|              |            |
                                           | 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                            2     1                                       |      6  1.3|
      Follicle, Cyst Multilocular          |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Chronic Active         | 3  2  2     2  2  2  2     1  1  2  2     2  2     2  2  1               |     53  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  69        |
      Inflammation, Acute                  |          2                                                               |      2  2.0|
      Inflammation, Chronic Active         | 2     2     2  3  4  3     2  2  1  1  1     2  2  3                     |     48  2.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Mineralization                       |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mineralization                       |    1  1     1  1  1  2        2  2           1  2  1  1                  |     29  1.2|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |          1     1     2           2     1                                 |     27  1.4|
      Seminiferous Tubule, Atrophy         |                4           2                                             |      8  3.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +     M  M  +  +     +  +  +  +     +  +  M  M  +                  |  41        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Pancreatic, Inflammation, Chronic    |                                                                          |            |
          Active                           |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Cyst                                 | X                    X                                                   |      2     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |       3                                                                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7|              |            |
                                           | 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fibrosis                             |                                                                          |      3  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Thrombosis                           |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  62        |
      Cyst                                 |                X                                                         |      1     |
      Ectopic Thyroid                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +               |  53        |
      Hyperplasia, Cystic                  | 2     2     1     2  2     2  1  2     1  2  2  2     2                  |     39  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperkeratosis                       |                                                 4                        |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cranium, Fibrous Osteodystrophy      |       X     X  X  X  X     X  X  X           X  X                        |     23     |
      Femur, Fibrous Osteodystrophy        |       X     X  X  X  X     X  X  X           X  X                        |     24     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +     +  +  +  +     +  +  +  +     +  +  +  +  +                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Compression                          |                                                    X                     |      4     |
      Hydrocephalus                        |                                                    2                     |      5  2.6|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      White Matter, Degeneration           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |             1        1        1                                          |     11  1.0|
      Inflammation, Chronic Active         |       2           2                             2                        |      8  2.1|
      Metaplasia, Osseous                  |                1                                                         |      3  1.3|
      Mineralization                       |             2  3  2  2     2                    2                        |     10  2.2|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05085-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 17:39:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7|              |            |
                                           | 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
     15000                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic Active         |             1     3  2           2              2                        |     11  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1           1                                         2                  |     17  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +                    +                                             |  10        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic Active |                            2                                             |      5  2.2|
      Cornea, Mineralization               |                            1                                             |      6  2.0|
      Lens, Cataract                       |    4                                                                     |      2  3.5|
      Retina, Atrophy                      |    4                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  60        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Nephropathy, Chronic                 | 3  3  4  1  4  4  4  4  1  4  4  4  3  2  3  4  4  3  3  1               |     68  2.9|
      Thrombosis                           |                                                 X                        |      1     |
      Renal Tubule, Hyperplasia            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
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