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https://ntp.niehs.nih.gov/go/3580

TDMS Study 05086-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                      O-BENZYL-P-CHLOROPHENOL


NTP Experiment-Test: 05086-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: GAVAGE                                                                                                     Time: 09:18:13




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-32-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           18                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            4           10           12                                     
    Natural Death                                      4            3            5           14                                     
    Dosing Accident                                                 3            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           40           33           25                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    70           70           70           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (50)         (50)         (70)                                   
      Foreign Body                                                  1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Duodenum                          (69)         (49)         (48)         (70)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Ulcer                                                                      4 (8%)       8 (11%)                               
   Liver                                              (70)         (50)         (50)         (70)                                   
      Foreign Body                                                                            1 (1%)                                
      Hyperplasia                                      3 (4%)       8 (16%)      7 (14%)      4 (6%)                                
      Inflammation, Chronic                                                      1 (2%)       5 (7%)                                
      Inflammation, Necrotizing                        6 (9%)                                 3 (4%)                                
      Necrosis, Coagulative                            1 (1%)       3 (6%)       3 (6%)      18 (26%)                               
   Mesentery                                          (5)          (8)          (2)                                                 
      Inflammation, Chronic                                         1 (13%)                                                         
      Fat, Necrosis                                    3 (60%)      2 (25%)      1 (50%)                                            
   Pancreas                                           (70)         (50)         (50)         (70)                                   
      Basophilic Focus                                                                        1 (1%)                                
      Inflammation, Chronic                            2 (3%)       2 (4%)       2 (4%)       4 (6%)                                
      Necrosis, Coagulative                            1 (1%)                                                                       
      Acinus, Atrophy                                               2 (4%)                                                          
      Acinus, Hyperplasia                              1 (1%)                                 1 (1%)                                
   Salivary Glands                                    (70)         (50)         (50)         (70)                                   
      Ectasia                                                       1 (2%)                                                          
      Inflammation, Chronic                            1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (51)         (50)         (70)                                   
      Hyperplasia, Squamous                            3 (4%)      10 (20%)     18 (36%)     22 (31%)                               
      Inflammation, Chronic Active                                                            1 (1%)                                
      Ulcer                                            2 (3%)       4 (8%)      12 (24%)     13 (19%)                               
   Stomach, Glandular                                 (70)         (51)         (50)         (70)                                   
      Inflammation, Chronic                            1 (1%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                                         1 (2%)       1 (2%)       1 (1%)                                
      Mucosa, Mineralization                           1 (1%)       7 (14%)     10 (20%)     17 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (50)         (49)         (70)                                   
      Artery, Inflammation, Necrotizing                1 (1%)                                                                       
      Atrium, Thrombosis                               1 (1%)       1 (2%)                    1 (1%)                                
      Myocardium, Degeneration                                                   1 (2%)                                             
      Myocardium, Mineralization                                                 2 (4%)       1 (1%)                                
      Valve, Inflammation, Chronic Active              1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (50)         (50)         (70)                                   
      Hyperplasia                                      4 (6%)       4 (8%)       4 (8%)       2 (3%)                                
   Adrenal Gland, Medulla                             (69)         (50)         (50)         (70)                                   
      Hyperplasia                                                   2 (4%)                    2 (3%)                                
   Islets, Pancreatic                                 (70)         (50)         (50)         (70)                                   
      Hyperplasia                                      1 (1%)       1 (2%)                                                          
   Pituitary Gland                                    (67)         (50)         (47)         (67)                                   
      Cyst                                                          1 (2%)                                                          
      Pars Distalis, Hyperplasia                       4 (6%)       7 (14%)      4 (9%)       1 (1%)                                
      Pars Intermedia, Hyperplasia                                                            1 (1%)                                
   Thyroid Gland                                      (69)         (50)         (50)         (70)                                   
      Inflammation, Chronic                            1 (1%)                                                                       
      C-Cell, Hyperplasia                              1 (1%)                                                                       
      Follicle, Hyperplasia                            8 (12%)      3 (6%)       4 (8%)       3 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                  (1)                                                              
      Duct, Dilatation                                              1 (100%)                                                        
   Ovary                                              (69)         (49)         (49)         (69)                                   
      Cyst                                            19 (28%)     17 (35%)     18 (37%)     13 (19%)                               
      Infarct                                          2 (3%)                    2 (4%)       2 (3%)                                
      Inflammation, Chronic Active                                                            1 (1%)                                
      Inflammation, Suppurative                        1 (1%)                                                                       
   Uterus                                             (70)         (52)         (56)         (70)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 (1%)                                                                       
      Dilatation                                                                 1 (2%)                                             
      Hemorrhage                                       2 (3%)       1 (2%)                                                          
      Inflammation, Suppurative                        1 (1%)                    1 (2%)       1 (1%)                                
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
      Endometrium, Hyperplasia                        44 (63%)     43 (83%)     42 (75%)     32 (46%)                               
   Vagina                                                                       (1)          (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (50)         (70)                                   
      Myelofibrosis                                   16 (23%)      3 (6%)       2 (4%)                                             
   Lymph Node                                         (69)         (50)         (48)         (70)                                   
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)                                                          
   Lymph Node, Mandibular                             (66)         (47)         (46)         (69)                                   
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
   Lymph Node, Mesenteric                             (61)         (48)         (46)         (62)                                   
      Ectasia                                                                    2 (4%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
   Spleen                                             (70)         (50)         (50)         (70)                                   
      Amyloid Deposition                               1 (1%)                    1 (2%)       1 (1%)                                
      Depletion Lymphoid                                            1 (2%)       1 (2%)       8 (11%)                               
      Hematopoietic Cell Proliferation                 7 (10%)      3 (6%)       7 (14%)     12 (17%)                               
      Hyperplasia, Lymphoid                            9 (13%)      5 (10%)      6 (12%)     12 (17%)                               
      Infiltration Cellular, Histiocyte                1 (1%)                                                                       
      Inflammation, Granulomatous                                                1 (2%)                                             
   Thymus                                             (65)         (44)         (44)         (62)                                   
      Atrophy                                                       1 (2%)       1 (2%)       1 (2%)                                
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (70)         (50)         (50)         (69)                                   
      Hyperkeratosis                                                                          1 (1%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Ulcer                                                                      1 (2%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (50)         (70)                                   
      Fibrous Osteodystrophy                           2 (3%)      20 (40%)     33 (66%)     37 (53%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (50)         (70)                                   
      Cyst Epithelial Inclusion                        1 (1%)                                                                       
      Hypothalamus, Compression                        1 (1%)       3 (6%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (69)         (50)         (50)         (70)                                   
      Foreign Body                                                  3 (6%)       2 (4%)       2 (3%)                                
      Inflammation, Chronic                            2 (3%)       1 (2%)       2 (4%)       2 (3%)                                
      Thrombosis                                                    1 (2%)                    1 (1%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (1%)                                                                       
   Nose                                               (70)         (50)         (50)         (70)                                   
      Foreign Body                                                  3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)          (2)                                    
      Phthisis Bulbi                                                                          1 (50%)                               
      Cornea, Inflammation, Chronic                    1 (50%)                   1 (100%)     1 (50%)                               
      Cornea, Inflammation, Necrotizing                1 (50%)                                                                      
   Harderian Gland                                    (5)          (3)          (3)          (3)                                    
      Hyperplasia                                      1 (20%)      1 (33%)                                                         
      Inflammation, Suppurative                                                  1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)         (70)         (70)                                   
      Amyloid Deposition                                                                      1 (1%)                                
      Hydronephrosis                                                1 (1%)                                                          
      Nephropathy                                     19 (27%)     49 (70%)     66 (94%)     66 (94%)                               
      Renal Tubule, Mineralization                     1 (1%)                                                                       
   Urinary Bladder                                    (70)         (50)         (50)         (70)                                   
      Inflammation                                                                            1 (1%)                                
      Inflammation, Necrotizing                        1 (1%)                                 1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            4           10                                     
    Moribund Sacrifice                                 2           12            6            8                                     
    Dosing Accident                                                 2                         2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           32           38           30                                     
    Natural Death                                                   1            1                                                  
    Moribund Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    70           70           70           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (70)         (50)         (48)         (67)                                   
      Ulcer                                                         1 (2%)       1 (2%)       2 (3%)                                
   Liver                                              (70)         (51)         (51)         (70)                                   
      Cyst                                             1 (1%)                                 1 (1%)                                
      Degeneration, Cystic                                                                    1 (1%)                                
      Fatty Change                                     5 (7%)                                                                       
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Hyperplasia                                      5 (7%)       4 (8%)       5 (10%)      3 (4%)                                
      Inflammation, Chronic                                         2 (4%)                    2 (3%)                                
      Inflammation, Necrotizing                        3 (4%)                                 2 (3%)                                
      Necrosis, Coagulative                            4 (6%)       4 (8%)       7 (14%)      5 (7%)                                
   Mesentery                                          (3)          (7)          (2)          (4)                                    
      Foreign Body                                                                            2 (50%)                               
      Inflammation, Necrotizing                                                               2 (50%)                               
      Fat, Necrosis                                    2 (67%)      6 (86%)      1 (50%)      1 (25%)                               
   Pancreas                                           (70)         (51)         (49)         (70)                                   
      Basophilic Focus                                                           1 (2%)                                             
      Cyst                                             1 (1%)                                                                       
      Inflammation, Chronic                            2 (3%)       2 (4%)       2 (4%)                                             
      Necrosis                                         1 (1%)                                                                       
   Salivary Glands                                    (70)         (50)         (50)         (70)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (1%)                                
   Stomach, Forestomach                               (70)         (53)         (51)         (70)                                   
      Cyst Epithelial Inclusion                        1 (1%)                                                                       
      Hyperplasia, Squamous                            4 (6%)      12 (23%)     11 (22%)     10 (14%)                               
      Inflammation, Necrotizing                                                               1 (1%)                                
      Ulcer                                            1 (1%)       7 (13%)      9 (18%)      6 (9%)                                
   Stomach, Glandular                                 (70)         (52)         (51)         (70)                                   
      Inflammation, Suppurative                        1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                            1 (1%)       5 (10%)      1 (2%)       1 (1%)                                
      Mucosa, Mineralization                           5 (7%)       6 (12%)     13 (25%)      6 (9%)                                
   Tooth                                              (2)                       (2)                                                 
      Developmental Malformation                       1 (50%)                                                                      
      Inflammation, Chronic Active                                               2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (50)         (49)         (70)                                   
      Bacterium                                                                               1 (1%)                                
      Artery, Inflammation, Necrotizing                             2 (4%)       2 (4%)                                             
      Atrium, Thrombosis                                                         1 (2%)       1 (1%)                                
      Myocardium, Degeneration                                                   5 (10%)      9 (13%)                               
      Myocardium, Mineralization                                                 1 (2%)                                             
      Pericardium, Inflammation, Subacute              1 (1%)                                                                       
      Valve, Inflammation, Chronic Active                                                     1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (52)         (50)         (69)                                   
      Capsule, Hyperplasia                             5 (7%)       1 (2%)       7 (14%)      6 (9%)                                
   Adrenal Gland, Cortex                              (70)         (52)         (50)         (69)                                   
      Degeneration, Fatty, Focal                                                 1 (2%)                                             
      Hyperplasia                                      4 (6%)      17 (33%)      8 (16%)      9 (13%)                               
      Hypertrophy, Focal                               5 (7%)       4 (8%)       4 (8%)       4 (6%)                                
   Adrenal Gland, Medulla                             (69)         (52)         (49)         (68)                                   
      Hyperplasia                                      1 (1%)                                 2 (3%)                                
   Islets, Pancreatic                                 (70)         (50)         (49)         (69)                                   
      Hyperplasia                                      2 (3%)                                                                       
   Pituitary Gland                                    (64)         (48)         (47)         (65)                                   
      Pars Distalis, Hyperplasia                       2 (3%)       1 (2%)       3 (6%)       1 (2%)                                
   Thyroid Gland                                      (70)         (50)         (50)         (70)                                   
      Follicle, Hyperplasia                            5 (7%)       3 (6%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (17)         (23)         (15)         (1)                                    
      Inflammation, Chronic Active                                  3 (13%)      1 (7%)                                             
      Duct, Dilatation                                17 (100%)    23 (100%)    14 (93%)      1 (100%)                              
   Seminal Vesicle                                    (70)         (50)         (48)         (70)                                   
      Inflammation, Chronic                            1 (1%)       1 (2%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (69)         (50)         (50)         (70)                                   
      Hyperplasia, Mast Cell                                        1 (2%)                                                          
      Myelofibrosis                                                              1 (2%)                                             
   Lymph Node                                         (69)         (50)         (48)         (69)                                   
      Mediastinal, Hyperplasia                                      1 (2%)                                                          
   Lymph Node, Mandibular                             (68)         (49)         (47)         (67)                                   
      Hyperplasia, Mast Cell                                        1 (2%)                                                          
   Lymph Node, Mesenteric                             (68)         (44)         (44)         (59)                                   
      Ectasia                                                       1 (2%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Sinus, Ectasia                                                             2 (5%)                                             
   Spleen                                             (70)         (50)         (49)         (70)                                   
      Depletion Lymphoid                               2 (3%)       2 (4%)       3 (6%)       6 (9%)                                
      Hematopoietic Cell Proliferation                 5 (7%)       7 (14%)      2 (4%)       1 (1%)                                
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)       6 (12%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
   Thymus                                             (62)         (38)         (41)         (61)                                   
      Depletion Lymphoid                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (70)         (50)         (50)         (70)                                   
      Edema                                            1 (1%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Ulcer                                                                                   1 (1%)                                
      Hair Follicle, Atrophy                                                                  1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (50)         (70)                                   
      Fibrous Osteodystrophy                                       16 (32%)     25 (50%)     28 (40%)                               
      Hyperostosis                                                                            1 (1%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05086-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:13  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (52)         (50)         (70)                                   
      Foreign Body                                                  2 (4%)                    3 (4%)                                
      Inflammation, Chronic                                                      1 (2%)       3 (4%)                                
      Inflammation, Subacute                           1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (1%)                                 1 (1%)                                
   Nose                                               (70)         (50)         (50)         (70)                                   
      Foreign Body                                                  1 (2%)                    2 (3%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (2)                                                 
      Cataract                                                                   1 (50%)                                            
      Phthisis Bulbi                                   1 (50%)                   1 (50%)                                            
      Cornea, Inflammation, Chronic                                 2 (100%)     1 (50%)                                            
   Harderian Gland                                    (3)          (4)          (4)          (3)                                    
      Hyperplasia                                                   1 (25%)                   1 (33%)                               
      Inflammation, Suppurative                                     1 (25%)                                                         
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)         (70)         (70)                                   
      Metaplasia, Osseous                                                        2 (3%)                                             
      Nephropathy                                     49 (70%)     61 (87%)     70 (100%)    69 (99%)                               
      Renal Tubule, Hyperplasia                                     1 (1%)       4 (6%)       6 (9%)                                
      Renal Tubule, Hyperplasia, Adenomatous                        1 (1%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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