National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3584

TDMS Study 05086-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                      O-BENZYL-P-CHLOROPHENOL


NTP Experiment-Test: 05086-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: GAVAGE                                                                                                     Time: 09:18:14




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-32-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           18                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            4           10           12                                     
    Natural Death                                      4            3            5           14                                     
    Dosing Accident                                                 3            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           40           33           25                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    70           70           70           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (67)         (47)         (48)         (63)                                   
   Intestine Large, Cecum                             (70)         (50)         (51)         (70)                                   
   Intestine Large, Rectum                            (67)         (50)         (50)         (70)                                   
   Intestine Small, Duodenum                          (69)         (49)         (48)         (70)                                   
   Intestine Small, Ileum                             (70)         (48)         (48)         (70)                                   
   Intestine Small, Jejunum                           (70)         (48)         (48)         (70)                                   
   Liver                                              (70)         (50)         (50)         (70)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Ear                         1 (2%)                                                          
      Hepatocellular Carcinoma                         2 (3%)       1 (2%)       3 (6%)       2 (3%)                                
      Hepatocellular Carcinoma, Multiple                                                      1 (1%)                                
      Hepatocellular Adenoma                           9 (13%)      9 (18%)     11 (22%)     10 (14%)                               
      Hepatocellular Adenoma, Multiple                 2 (3%)       5 (10%)      4 (8%)       4 (6%)                                
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Mesentery                                                 1 (2%)                                                          
   Mesentery                                          (5)          (8)          (2)                                                 
      Hemangioma                                                    1 (13%)                                                         
      Hemangiosarcoma                                               1 (13%)                                                         
      Mast Cell Tumor Malignant                                     1 (13%)                                                         
   Pancreas                                           (70)         (50)         (50)         (70)                                   
   Salivary Glands                                    (70)         (50)         (50)         (70)                                   
   Stomach                                            (70)         (51)         (50)         (70)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Stomach, Forestomach                               (70)         (51)         (50)         (70)                                   
      Squamous Cell Papilloma                                       3 (6%)       2 (4%)       1 (1%)                                
   Stomach, Glandular                                 (70)         (51)         (50)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (50)         (49)         (70)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (50)         (50)         (70)                                   
   Adrenal Gland, Cortex                              (70)         (50)         (50)         (70)                                   
   Islets, Pancreatic                                 (70)         (50)         (50)         (70)                                   
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (67)         (50)         (47)         (67)                                   
      Pars Distalis, Adenoma                           8 (12%)      4 (8%)       5 (11%)      1 (1%)                                
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (69)         (50)         (50)         (70)                                   
      Follicle, Adenoma                                1 (1%)       1 (2%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (69)         (49)         (49)         (69)                                   
      Granulosa Cell Tumor Benign                      2 (3%)                                                                       
      Hemangioma                                                                              1 (1%)                                
      Hemangiosarcoma                                  1 (1%)                                                                       
      Teratoma                                         1 (1%)                                                                       
      Thecoma Benign                                   1 (1%)                                                                       
      Bilateral, Hemangiosarcoma                                    1 (2%)                                                          
   Uterus                                             (70)         (52)         (56)         (70)                                   
      Hemangiosarcoma                                  1 (1%)       1 (2%)                                                          
      Leiomyoma                                        1 (1%)       1 (2%)       1 (2%)                                             
      Leiomyosarcoma                                                2 (4%)                    1 (1%)                                
      Polyp Stromal                                    1 (1%)       2 (4%)                                                          
   Vagina                                                                       (1)          (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (50)         (70)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Mesentery                                                 1 (2%)                                                          
   Lymph Node                                         (69)         (50)         (48)         (70)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (66)         (47)         (46)         (69)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Ear                         1 (2%)                                                          
   Lymph Node, Mesenteric                             (61)         (48)         (46)         (62)                                   
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Mesentery                                                 1 (2%)                                                          
   Spleen                                             (70)         (50)         (50)         (70)                                   
      Hemangiosarcoma                                               2 (4%)       1 (2%)       1 (1%)                                
      Mast Cell Tumor Malignant, Metastatic,                                                                                        
          Mesentery                                                 1 (2%)                                                          
   Thymus                                             (65)         (44)         (44)         (62)                                   
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (65)         (49)         (47)         (64)                                   
   Skin                                               (70)         (50)         (50)         (69)                                   
      Subcutaneous Tissue, Fibrosarcoma                3 (4%)                                 1 (1%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                  1 (1%)                                                                       
      Subcutaneous Tissue, Neurofibrosarcoma           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (50)         (70)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Skeletal Muscle                                    (2)                                                                           
      Rhabdomyosarcoma                                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (50)         (70)                                   
      Meningioma Malignant                                                       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (69)         (50)         (50)         (70)                                   
      Alveolar/Bronchiolar Adenoma                     3 (4%)       1 (2%)                    4 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       2 (4%)       1 (2%)       1 (1%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)       2 (3%)                                
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle    1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      Pinna, Fibrous Histiocytoma                                   1 (100%)                                                        
   Harderian Gland                                    (5)          (3)          (3)          (3)                                    
      Adenoma                                          4 (80%)      1 (33%)      2 (67%)      3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)         (70)         (70)                                   
   Urinary Bladder                                    (70)         (50)         (50)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(70)        *(70)        *(70)                                   
      Lymphoma Malignant Histiocytic                                3 (4%)       4 (6%)       3 (4%)                                
      Lymphoma Malignant Lymphocytic                   2 (3%)       1 (1%)                                                          
      Lymphoma Malignant Mixed                         5 (7%)       1 (1%)       3 (4%)       1 (1%)                                
      Lymphoma Malignant Undifferentiated Cell         2 (3%)       4 (6%)       3 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          35          29          29                                       
     Total Primary Neoplasms                           55          52          45          36                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          25          22          23                                       
     Total Benign Neoplasms                            34          28          26          25                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          16          15          10                                       
     Total Malignant Neoplasms                         21          24          19          11                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           2           3                                       
     Total Metastatic Neoplasm                          1           6           3           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            4           10                                     
    Moribund Sacrifice                                 2           12            6            8                                     
    Dosing Accident                                                 2                         2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           32           38           30                                     
    Natural Death                                                   1            1                                                  
    Moribund Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    70           70           70           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (70)         (50)         (48)         (64)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (69)         (51)         (48)         (65)                                   
      Hemangiosarcoma                                  1 (1%)                                                                       
   Liver                                              (70)         (51)         (51)         (70)                                   
      Hemangioma, Multiple                             1 (1%)                                                                       
      Hemangiosarcoma                                  2 (3%)                    1 (2%)       1 (1%)                                
      Hemangiosarcoma, Multiple                        1 (1%)                                 1 (1%)                                
      Hepatocellular Carcinoma                         7 (10%)     11 (22%)      9 (18%)      5 (7%)                                
      Hepatocellular Carcinoma, Multiple                            1 (2%)       2 (4%)                                             
      Hepatocellular Adenoma                           8 (11%)     13 (25%)     15 (29%)     13 (19%)                               
      Hepatocellular Adenoma, Multiple                13 (19%)      5 (10%)      5 (10%)      2 (3%)                                
   Mesentery                                          (3)          (7)          (2)          (4)                                    
      Hemangiosarcoma                                                                         1 (25%)                               
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (14%)                                                         
   Pancreas                                           (70)         (51)         (49)         (70)                                   
      Squamous Cell Carcinoma, Metastatic                           1 (2%)                                                          
   Salivary Glands                                    (70)         (50)         (50)         (70)                                   
      Hemangioma                                       1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (53)         (51)         (70)                                   
      Squamous Cell Carcinoma                          1 (1%)       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (1%)                    2 (4%)       2 (3%)                                
   Stomach, Glandular                                 (70)         (52)         (51)         (70)                                   
      Hemangiosarcoma                                                                         1 (1%)                                
   Tooth                                              (2)                       (2)                                                 
      Adamantinoma Benign                              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (50)         (49)         (70)                                   
      Hemangiosarcoma                                                                         1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (52)         (50)         (69)                                   
      Capsule, Adenoma                                 1 (1%)       1 (2%)       4 (8%)       1 (1%)                                
   Adrenal Gland, Cortex                              (70)         (52)         (50)         (69)                                   
      Adenoma                                          1 (1%)       1 (2%)                    1 (1%)                                
   Adrenal Gland, Medulla                             (69)         (52)         (49)         (68)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (1%)                                                                       
   Thyroid Gland                                      (70)         (50)         (50)         (70)                                   
      Follicle, Adenoma                                1 (1%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (70)         (50)         (49)         (70)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
   Seminal Vesicle                                    (70)         (50)         (48)         (70)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (69)         (50)         (50)         (70)                                   
      Hemangioma                                                                              1 (1%)                                
      Hemangiosarcoma                                                            1 (2%)       1 (1%)                                
   Lymph Node                                         (69)         (50)         (48)         (69)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
      Lumbar, Hemangiosarcoma                                                                 1 (1%)                                
   Lymph Node, Mandibular                             (68)         (49)         (47)         (67)                                   
      Carcinoma, Metastatic, Nose                      1 (1%)                                                                       
   Lymph Node, Mesenteric                             (68)         (44)         (44)         (59)                                   
   Spleen                                             (70)         (50)         (49)         (70)                                   
      Hemangiosarcoma                                  1 (1%)                    2 (4%)       1 (1%)                                
   Thymus                                             (62)         (38)         (41)         (61)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (70)         (50)         (50)         (70)                                   
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (1%)                                
      Subcutaneous Tissue, Hemangiosarcoma                          2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Squamous Cell Carcinoma, Metastatic                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (52)         (50)         (70)                                   
      Alveolar/Bronchiolar Adenoma                    13 (19%)     11 (21%)      5 (10%)      6 (9%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (1%)       2 (4%)       1 (2%)       1 (1%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (1%)       1 (2%)                                                          
      Carcinoma, Metastatic, Nose                      1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       4 (8%)       2 (4%)       1 (1%)                                
      Mediastinum, Hemangiosarcoma                                               1 (2%)                                             
   Nose                                               (70)         (50)         (50)         (70)                                   
      Carcinoma                                        1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (4)          (4)          (3)                                    
      Adenoma                                          3 (100%)     2 (50%)      4 (100%)     2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)         (70)         (70)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (1%)                                                          
      Renal Tubule, Adenocarcinoma                                               2 (3%)       1 (1%)                                
                                                             Page   9                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Renal Tubule, Adenoma                                         2 (3%)       2 (3%)       2 (3%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(70)        *(70)        *(70)                                   
      Lymphoma Malignant Mixed                         1 (1%)                                 1 (1%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05086-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 09:18:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      120MG/KG     240MG/KG     480MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          36          38          32                                       
     Total Primary Neoplasms                           63          56          60          47                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          27          28          28                                       
     Total Benign Neoplasms                            45          38          38          30                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          16          17          11                                       
     Total Malignant Neoplasms                         18          18          22          17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5           2           1                                       
     Total Metastatic Neoplasm                          4          11           2           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.