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TDMS Study 05086-02 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/11/94   
EXP: 05086                 O-BENZYL-P-CHLOROPHENOL             TIME: 09:32:54   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 61201C   
CONT: N01-ES-45042                                             CAS: 120-32-1    
PATHOLOGIST: M. RYAN                                                            
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/11/94  
EXP: 05086                 O-BENZYL-P-CHLOROPHENOL             TIME: 09:32:54  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 61201C  
CONT: N01-ES-45042                                             CAS: 120-32-1   
PATHOLOGIST: M. RYAN                                                           

                              O-BENZYL-P-CHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 5      CENSORED DEATHS 20   TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      646   650   694   699   721                                               |
 |  CENSORED DEATHS                                                               |
 |      93    93    93    93    93    93    93    93    93    94                  |
 |      455   455   455   455   455   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 120MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 15     CENSORED DEATHS 22   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      349   412   464   552   631   650   657   661   673   677                 |
 |      682   687   693   706   707                                               |
 |  CENSORED DEATHS                                                               |
 |      10    24    93    93    93    93    93    93    93    93                  |
 |      93    93    455   455   455   455   455   456   456   456                 |
 |      456   456                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 240MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 10     CENSORED DEATHS 20   TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      370   433   472   547   588   602   615   659   699   713                 |
 |  CENSORED DEATHS                                                               |
 |      93    93    93    93    93    93    93    93    93    93                  |
 |      455   455   455   455   455   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                              O-BENZYL-P-CHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 480MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 18     CENSORED DEATHS 22   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      194   275   387   421   424   461   465   558   619   643                 |
 |      651   657   680   687   692   700   706   713                             |
 |  CENSORED DEATHS                                                               |
 |      9     9     93    93    93    93    93    93    93    93                  |
 |      93    93    455   455   455   455   455   456   456   456                 |
 |      456   456                                                                 |
 |                                                                                |
 ==================================================================================

                              O-BENZYL-P-CHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   722 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0  96.0  90.0      |
 |           |                                                                    |
 |           |                                                                    |
 |120MG/KG   |   100.0 100.0 100.0  98.3  96.6  94.5  94.5  92.4  84.0  69.3      |
 |           |                                                                    |
 |           |                                                                    |
 |240MG/KG   |   100.0 100.0 100.0 100.0  98.3  94.7  94.7  88.6  84.6  80.6      |
 |           |                                                                    |
 |           |                                                                    |
 |480MG/KG   |   100.0 100.0  98.3  96.6  91.4  87.1  87.1  85.0  76.5  63.8      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      120MG/KG     240MG/KG     480MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       90.0%        69.3%        80.6%        63.8%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.007      P=0.014      P=0.222      P=0.002  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       682.0        613.4        569.8        551.8    |
 |NATURAL DEATHS (C)      |       (14.6)       (29.6)       (36.1)       (38.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       591.2        550.7        572.3        529.9    |
 |(STANDARD ERROR)        |       (26.8)       (28.7)       (26.7)       (29.0)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                              O-BENZYL-P-CHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 13     CENSORED DEATHS 20   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      560   603   605   640   645   650   692   694   699   706                 |
 |      707   713   719                                                           |
 |  CENSORED DEATHS                                                               |
 |      93    93    93    93    93    93    93    93    93    93                  |
 |      455   455   455   455   455   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 120MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 7      CENSORED DEATHS 23   TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      510   588   588   600   664   692   697                                   |
 |  CENSORED DEATHS                                                               |
 |      10    14    17    93    93    93    93    93    93    93                  |
 |      93    93    93    455   455   455   455   455   456   456                 |
 |      456   456   456                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 240MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 15     CENSORED DEATHS 22   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      196   449   482   569   622   652   668   678   685   691                 |
 |      692   706   707   714   714                                               |
 |  CENSORED DEATHS                                                               |
 |      7     7     93    93    93    93    93    93    93    93                  |
 |      93    93    455   455   455   455   455   456   456   456                 |
 |      456   456                                                                 |
 |                                                                                |
 ==================================================================================

                              O-BENZYL-P-CHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 480MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 26     CENSORED DEATHS 19   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      8     110   197   269   282   303   422   437   482   521                 |
 |      532   554   570   608   618   647   651   652   658   666                 |
 |      689   699   707   714   714   720                                         |
 |  CENSORED DEATHS                                                               |
 |      8     93    93    93    93    93    93    93    93    93                  |
 |      455   455   455   455   455   456   456   456   456                       |
 |                                                                                |
 ==================================================================================

                              O-BENZYL-P-CHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   722 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  94.0  88.0  74.0      |
 |           |                                                                    |
 |           |                                                                    |
 |120MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  97.9  91.5  89.4  85.1      |
 |           |                                                                    |
 |           |                                                                    |
 |240MG/KG   |   100.0 100.0  98.3  98.3  98.3  94.5  94.5  92.4  88.2  69.3      |
 |           |                                                                    |
 |           |                                                                    |
 |480MG/KG   |    98.6  96.9  93.6  90.2  88.5  84.9  80.8  76.8  64.7  50.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      120MG/KG     240MG/KG     480MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       74.0%        85.1%        69.3%        50.5%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.314N     P=0.665      P=0.007  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       664.1        619.9        615.0        516.5    |
 |NATURAL DEATHS (C)      |       (14.1)       (25.6)       (36.8)       (40.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       583.3        553.5        550.7        520.3    |
 |(STANDARD ERROR)        |       (26.5)       (29.8)       (29.1)       (28.8)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                      O-BENZYL-P-CHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        120MG/KG         = 2
                                                        240MG/KG         = 3
                                                        480MG/KG         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                              4                       2  3                                           1
      |                                4            4          2  3      2  3
      |
      |                                             4                 4  2  3     23                          1       1
   95 +                                                               4    4      23           2
      |
      |                                                                                        2    3       2         1  1
      |                                                                    4     4                  3  3
P  90 +                                                                                                     2 2          11
E     |                                                                          44                    3 3    22
R     |                                                                           4             4
C     |                                                                                                  3     2 2
E  85 +                                                                                         4         4      3    3
N     |                                                                                                          2 2
T     |                                                                                                   4  4        3 3
      |                                                                                                      44
S  80 +                                                                                                            22   3 3
U     |                                                                                                       44
R     |                                                                                                             22
V     |                                                                                                        4    4
I  75 +                                                                                                             44
V     |                                                                                                              2 2
A     |
L     |
   70 +                                                                                                              44
      |                                                                                                                2  2
      |                                                                                                               44
      |                                                                                                                44
   65 +
      |                                                                                                                 4 4
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 6 obs hidden.

                                                      O-BENZYL-P-CHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        120MG/KG         = 2
                                                        240MG/KG         = 3
                                                        480MG/KG         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1 4                            3                                                2       1
      |   4               4            3                                        3
      |                   4             4                                               2       1   2   1
      |                                                                         3   3
   95 +                                 4          4                                3             3
      |                                            4 4                                              2  21    1
      |                                              4  4                                         3       3  11
      |                                                                                                2         2
   90 +                                                 4                  4                              3    3
      |                                                                    4 4                                 3 23  2
      |                                                                      4      4                         1      12
      |                                                                                                           33 11
P  85 +                                                                             4      4                          2   2
E     |                                                                                                            33
R     |                                                                                    44                         11
C     |                                                                                     4   4                   33
E  80 +
N     |                                                                                         4 4
T     |                                                                                                              3 11
      |                                                                                           4     4               11
S  75 +                                                                                                 4 4
U     |                                                                                                                3311
R     |                                                                                                   4   4
V     |
I  70 +
V     |                                                                                                       44        3 3
A     |
L     |
   65 +                                                                                                        4  4
      |
      |                                                                                                           4  4
      |
   60 +                                                                                                              44
      |                                                                                                               44
      |
      |                                                                                                                44
   55 +
      |
      |                                                                                                                 44
      |
   50 +                                                                                                                  44
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.