TDMS Study 05086-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/11/94
EXP: 05086 O-BENZYL-P-CHLOROPHENOL TIME: 09:32:54
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 61201C
CONT: N01-ES-45042 CAS: 120-32-1
PATHOLOGIST: M. RYAN
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/11/94
EXP: 05086 O-BENZYL-P-CHLOROPHENOL TIME: 09:32:54
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 61201C
CONT: N01-ES-45042 CAS: 120-32-1
PATHOLOGIST: M. RYAN
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 5 CENSORED DEATHS 20 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 646 650 694 699 721 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 94 |
| 455 455 455 455 455 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 120MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 15 CENSORED DEATHS 22 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 349 412 464 552 631 650 657 661 673 677 |
| 682 687 693 706 707 |
| CENSORED DEATHS |
| 10 24 93 93 93 93 93 93 93 93 |
| 93 93 455 455 455 455 455 456 456 456 |
| 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 240MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 10 CENSORED DEATHS 20 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 370 433 472 547 588 602 615 659 699 713 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| 455 455 455 455 455 456 456 456 456 456 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 480MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 18 CENSORED DEATHS 22 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 194 275 387 421 424 461 465 558 619 643 |
| 651 657 680 687 692 700 706 713 |
| CENSORED DEATHS |
| 9 9 93 93 93 93 93 93 93 93 |
| 93 93 455 455 455 455 455 456 456 456 |
| 456 456 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 722 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 |
| | |
| | |
|120MG/KG | 100.0 100.0 100.0 98.3 96.6 94.5 94.5 92.4 84.0 69.3 |
| | |
| | |
|240MG/KG | 100.0 100.0 100.0 100.0 98.3 94.7 94.7 88.6 84.6 80.6 |
| | |
| | |
|480MG/KG | 100.0 100.0 98.3 96.6 91.4 87.1 87.1 85.0 76.5 63.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.0% 69.3% 80.6% 63.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.007 P=0.014 P=0.222 P=0.002 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 682.0 613.4 569.8 551.8 |
|NATURAL DEATHS (C) | (14.6) (29.6) (36.1) (38.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 591.2 550.7 572.3 529.9 |
|(STANDARD ERROR) | (26.8) (28.7) (26.7) (29.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 13 CENSORED DEATHS 20 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 560 603 605 640 645 650 692 694 699 706 |
| 707 713 719 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| 455 455 455 455 455 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 120MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 7 CENSORED DEATHS 23 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 510 588 588 600 664 692 697 |
| CENSORED DEATHS |
| 10 14 17 93 93 93 93 93 93 93 |
| 93 93 93 455 455 455 455 455 456 456 |
| 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 240MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 15 CENSORED DEATHS 22 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 196 449 482 569 622 652 668 678 685 691 |
| 692 706 707 714 714 |
| CENSORED DEATHS |
| 7 7 93 93 93 93 93 93 93 93 |
| 93 93 455 455 455 455 455 456 456 456 |
| 456 456 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 480MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 26 CENSORED DEATHS 19 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 8 110 197 269 282 303 422 437 482 521 |
| 532 554 570 608 618 647 651 652 658 666 |
| 689 699 707 714 714 720 |
| CENSORED DEATHS |
| 8 93 93 93 93 93 93 93 93 93 |
| 455 455 455 455 455 456 456 456 456 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 722 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 74.0 |
| | |
| | |
|120MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 97.9 91.5 89.4 85.1 |
| | |
| | |
|240MG/KG | 100.0 100.0 98.3 98.3 98.3 94.5 94.5 92.4 88.2 69.3 |
| | |
| | |
|480MG/KG | 98.6 96.9 93.6 90.2 88.5 84.9 80.8 76.8 64.7 50.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 85.1% 69.3% 50.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.314N P=0.665 P=0.007 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 664.1 619.9 615.0 516.5 |
|NATURAL DEATHS (C) | (14.1) (25.6) (36.8) (40.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 583.3 553.5 550.7 520.3 |
|(STANDARD ERROR) | (26.5) (29.8) (29.1) (28.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-BENZYL-P-CHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
120MG/KG = 2
240MG/KG = 3
480MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 3 1
| 4 4 2 3 2 3
|
| 4 4 2 3 23 1 1
95 + 4 4 23 2
|
| 2 3 2 1 1
| 4 4 3 3
P 90 + 2 2 11
E | 44 3 3 22
R | 4 4
C | 3 2 2
E 85 + 4 4 3 3
N | 2 2
T | 4 4 3 3
| 44
S 80 + 22 3 3
U | 44
R | 22
V | 4 4
I 75 + 44
V | 2 2
A |
L |
70 + 44
| 2 2
| 44
| 44
65 +
| 4 4
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
O-BENZYL-P-CHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
120MG/KG = 2
240MG/KG = 3
480MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 2 1
| 4 4 3 3
| 4 4 2 1 2 1
| 3 3
95 + 4 4 3 3
| 4 4 2 21 1
| 4 4 3 3 11
| 2 2
90 + 4 4 3 3
| 4 4 3 23 2
| 4 4 1 12
| 33 11
P 85 + 4 4 2 2
E | 33
R | 44 11
C | 4 4 33
E 80 +
N | 4 4
T | 3 11
| 4 4 11
S 75 + 4 4
U | 3311
R | 4 4
V |
I 70 +
V | 44 3 3
A |
L |
65 + 4 4
|
| 4 4
|
60 + 44
| 44
|
| 44
55 +
|
| 44
|
50 + 44
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.