National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3592

TDMS Study 05086-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                      O-BENZYL-P-CHLOROPHENOL


NTP Experiment-Test: 05086-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: GAVAGE                                                                                                     Time: 06:48:22




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-32-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10           10           10            9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17                                     12                                     
    Dosing Accident                                    2                                      1                                     
    Natural Death                                      5                                      7                         1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                                     30                                     
  Animals Examined Microscopically                    60           10                        60           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (10)                      (50)                                   
      Muscularis, Inflammation, Chronic                             1 (10%)                                                         
   Intestine Large, Colon                             (59)         (10)                      (50)                                   
      Parasite Metazoan                                3 (5%)                                                                       
   Intestine Large, Rectum                            (59)         (10)                      (50)                                   
      Parasite Metazoan                                3 (5%)       1 (10%)                   6 (12%)                               
   Intestine Small, Duodenum                          (60)         (10)                      (50)                                   
      Inflammation, Necrotizing                        2 (3%)                                                                       
   Liver                                              (60)         (10)                      (54)                                   
      Basophilic Focus                                41 (68%)                               43 (80%)                               
      Clear Cell Focus                                 6 (10%)                               10 (19%)                               
      Eosinophilic Focus                               1 (2%)                                 2 (4%)                                
      Fatty Change                                     1 (2%)                                 4 (7%)                                
      Hepatodiaphragmatic Nodule                       8 (13%)                                9 (17%)                               
      Inflammation, Granulomatous                      8 (13%)                                9 (17%)                               
      Mixed Cell Focus                                                                        3 (6%)                                
      Bile Duct, Hyperplasia                          35 (58%)                               37 (69%)                               
      Centrilobular, Necrosis                                                                 3 (6%)                                
   Mesentery                                          (4)                                    (3)                                    
      Fat, Necrosis                                    4 (100%)                               2 (67%)                               
   Pancreas                                           (60)         (10)                      (50)                                   
      Inflammation, Chronic                                         1 (10%)                                                         
      Acinus, Atrophy                                 11 (18%)                               12 (24%)                               
      Acinus, Hyperplasia                              4 (7%)                                 1 (2%)                                
   Pharynx                                                                                   (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
   Salivary Glands                                    (60)         (10)                      (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (10)                      (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Necrotizing                        2 (3%)                                 2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Epithelium, Hyperplasia                          1 (2%)                                 2 (4%)                                
   Stomach, Glandular                                 (59)         (10)                      (50)                                   
      Inflammation, Necrotizing                        1 (2%)                                 3 (6%)                                
      Mineralization                                   3 (5%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (10)                      (50)                                   
      Thrombosis                                                                              1 (2%)                                
      Myocardium, Degeneration, Chronic               40 (67%)      3 (30%)                  43 (86%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)                      (50)                                   
      Hyperplasia                                     15 (25%)                               14 (28%)                               
      Hypertrophy                                      1 (2%)                                 2 (4%)                                
      Necrosis                                         1 (2%)                                 2 (4%)                                
   Adrenal Gland, Medulla                             (60)         (10)                      (50)                                   
      Hyperplasia                                      8 (13%)                                4 (8%)                                
   Islets, Pancreatic                                 (60)         (10)                      (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (56)         (10)                      (44)                                   
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (60)         (10)                      (51)                                   
      Pars Distalis, Ectasia                                                                  1 (2%)                                
      Pars Distalis, Hyperplasia                      27 (45%)                               22 (43%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (60)         (10)                      (50)                                   
      C-Cell, Hyperplasia                             19 (32%)                                8 (16%)                               
      Follicular Cell, Hyperplasia                     5 (8%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (10)                      (48)                                   
      Hyperplasia                                      1 (2%)                                 2 (4%)                                
      Inflammation, Chronic Active                     2 (3%)                                 2 (4%)                                
      Duct, Dilatation                                 1 (2%)                                                                       
   Ovary                                              (60)         (10)                      (52)         (1)                       
      Cyst                                             2 (3%)                                 4 (8%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Periovarian Tissue, Cyst                         1 (2%)                                 1 (2%)                                
   Vagina                                                                                    (1)                                    
      Inflammation, Acute                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                      (50)                                   
      Femoral, Hyperplasia, Reticulum Cell                          1 (10%)                                                         
   Lymph Node, Mesenteric                             (59)         (10)                      (48)                                   
      Edema                                            1 (2%)                                                                       
   Spleen                                             (60)         (10)                      (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
   Thymus                                             (58)         (10)                      (46)                                   
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (9)                       (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Skin                                               (60)         (10)                      (50)                                   
      Inflammation, Chronic Active                     2 (3%)                                 1 (2%)                                
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                    (1)                                    
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                      (50)                                   
      Compression                                      5 (8%)                                 2 (4%)                                
      Developmental Malformation                       1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                      (50)                                   
      Foreign Body                                     1 (2%)                                 2 (4%)                                
      Inflammation, Chronic Active                     8 (13%)      2 (20%)                   1 (2%)                                
      Inflammation, Necrotizing                        2 (3%)                                 1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (7%)                                 8 (16%)                               
   Nose                                               (60)         (10)                      (50)                                   
      Mucosa, Inflammation, Suppurative                2 (3%)                                 3 (6%)                                
      Nasolacrimal Duct, Inflammation, Suppurative                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                       (4)                                    
      Degeneration                                                                            1 (25%)                               
      Lens, Cataract                                                1 (100%)                  2 (50%)                               
      Retina, Atrophy                                               1 (100%)                  1 (25%)                               
   Harderian Gland                                                 (1)                       (1)                                    
      Inflammation, Chronic Active                                  1 (100%)                                                        
   Zymbal's Gland                                                                            (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (60)         (10)                      
      Infarct                                                                                 1 (2%)                                
      Nephropathy                                     55 (92%)      1 (10%)                  57 (95%)      3 (30%)                  
      Corticomedullary Junction, Concretion                         1 (10%)                                                         
      Corticomedullary Junction, Mineralization                     5 (50%)                                6 (60%)                  
      Pelvis, Inflammation, Suppurative                1 (2%)                                                                       
      Pelvis, Mineralization                           3 (5%)                                 2 (3%)                                
   Urinary Bladder                                    (60)         (10)                      (50)                                   
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                  9            8            9           10            9            8           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15                                     18                                     
    Natural Death                                      7                         1            3            1                        
    Dosing Accident                                    1            2                         1                         2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                     28                                     
  Animals Examined Microscopically                    60            8                        60           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (52)                                   (60)         (10)                      
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Inflammation, Necrotizing                                                               1 (2%)                                
      Muscularis, Inflammation, Chronic                                                                    1 (10%)                  
   Intestine Large, Cecum                             (51)                                   (60)         (10)                      
      Inflammation, Necrotizing                                                               1 (2%)                                
   Intestine Large, Rectum                            (51)                                   (60)         (9)                       
      Parasite Metazoan                                3 (6%)                                 1 (2%)                                
   Intestine Small, Duodenum                          (51)                                   (60)         (10)                      
      Inflammation, Necrotizing                                                               1 (2%)                                
   Liver                                              (52)                                   (60)         (10)                      
      Basophilic Focus                                41 (79%)                               43 (72%)                               
      Clear Cell Focus                                 9 (17%)                               16 (27%)                               
      Degeneration, Cystic                             1 (2%)                                 2 (3%)                                
      Eosinophilic Focus                               3 (6%)                                 2 (3%)                                
      Fatty Change                                     1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       9 (17%)                                8 (13%)                               
      Inflammation, Granulomatous                      5 (10%)                                2 (3%)                                
      Inflammation, Necrotizing                        1 (2%)                                 2 (3%)                                
      Bile Duct, Hyperplasia                          33 (63%)                               25 (42%)                               
   Mesentery                                          (1)                                    (5)                                    
      Fibrosis                                         1 (100%)                                                                     
      Hemorrhage                                                                              1 (20%)                               
      Fat, Necrosis                                                                           3 (60%)                               
   Pancreas                                           (50)                                   (60)         (10)                      
      Acinus, Atrophy                                  8 (16%)                               16 (27%)                               
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Salivary Glands                                    (50)                                   (60)         (10)                      
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (52)                                   (60)         (10)                      
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                                                                   2 (3%)                                
      Inflammation, Necrotizing                        1 (2%)                                 5 (8%)                                
   Stomach, Glandular                                 (51)                                   (60)         (10)                      
      Inflammation, Necrotizing                                                               3 (5%)                                
      Mineralization                                                                          2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (51)                                   (60)         (10)                      
      Mineralization                                                                          1 (2%)                                
      Myocardium, Degeneration, Chronic               42 (82%)                               44 (73%)      2 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (51)                                   (60)         (10)                      
      Hyperplasia                                     10 (20%)                               26 (43%)                               
      Hypertrophy                                      4 (8%)                                 2 (3%)                                
      Necrosis                                         1 (2%)                                                                       
   Adrenal Gland, Medulla                             (51)                                   (60)         (10)                      
      Hyperplasia                                      3 (6%)                                10 (17%)                               
   Parathyroid Gland                                  (46)                                   (57)         (8)                       
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (51)                                   (60)         (10)                      
      Pars Distalis, Ectasia                                                                  1 (2%)                                
      Pars Distalis, Hyperplasia                      30 (59%)                               28 (47%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (51)                                   (60)         (10)                      
      C-Cell, Hyperplasia                             11 (22%)                               22 (37%)                               
      Follicular Cell, Hyperplasia                     1 (2%)                                 4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)                                   (56)         (10)                      
      Hyperplasia                                      5 (10%)                                1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Duct, Dilatation                                 2 (4%)                                                                       
   Ovary                                              (51)                                   (60)         (10)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             3 (6%)                                 1 (2%)                                
   Uterus                                             (53)                                   (60)         (10)                      
      Dilatation                                       2 (4%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (51)                                   (60)         (10)                      
      Femoral, Hyperplasia, Reticulum Cell                                                                 1 (10%)                  
   Lymph Node                                         (51)                                   (60)         (10)                      
      Mediastinal, Edema                               1 (2%)                                                                       
   Spleen                                             (51)                                   (60)         (10)                      
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                   (60)         (10)                      
      Hyperplasia                                      2 (4%)                                                                       
   Skin                                               (50)                                   (60)         (10)                      
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (51)                                   (60)         (10)                      
      Compression                                      1 (2%)                                 6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)                                   (59)         (10)                      
      Inflammation, Chronic Active                     1 (2%)                                 4 (7%)       2 (20%)                  
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Mineralization                                                                          2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 7 (12%)                               
   Nose                                               (51)                                   (60)         (10)                      
      Mucosa, Inflammation, Suppurative                6 (12%)                                4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (1)                       (6)          (1)                       
      Degeneration                                     2 (29%)                                3 (50%)                               
      Inflammation, Chronic Active                                                            2 (33%)                               
      Lens, Cataract                                   3 (43%)      1 (100%)                  1 (17%)      1 (100%)                 
      Retina, Atrophy                                  3 (43%)                                             1 (100%)                 
   Harderian Gland                                    (1)                                                 (1)                       
      Inflammation, Chronic Active                     1 (100%)                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (8)                       (60)         (10)                      
      Atrophy                                                                                 1 (2%)                                
      Calculus Micro Observation Only                                                         2 (3%)                                
      Mineralization                                                                          1 (2%)                                
      Nephropathy                                     59 (98%)      3 (38%)                  60 (100%)     7 (70%)                  
      Corticomedullary Junction, Mineralization                     3 (38%)                                1 (10%)                  
      Pelvis, Inflammation, Suppurative                1 (2%)                                 2 (3%)                                
      Pelvis, Mineralization                           2 (3%)                                16 (27%)                               
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
   Urinary Bladder                                    (51)                                   (60)         (10)                      
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16                                     13                                     
    Natural Death                                      5                                     11                                     
    Dosing Accident                                    6                                      2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23                                     24                                     
  Animals Examined Microscopically                    60           10                        60           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (10)                      (50)                                   
      Foreign Body                                     2 (3%)                                                                       
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Muscularis, Inflammation, Chronic                             2 (20%)                                                         
   Intestine Large, Cecum                             (58)         (10)                      (48)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
   Intestine Large, Colon                             (60)         (10)                      (50)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Rectum                            (60)         (10)                      (49)                                   
      Parasite Metazoan                                2 (3%)       1 (10%)                   7 (14%)                               
   Intestine Small, Jejunum                           (59)         (10)                      (48)                                   
      Inflammation, Necrotizing                        1 (2%)                                                                       
   Liver                                              (60)         (10)                      (51)                                   
      Basophilic Focus                                35 (58%)                               33 (65%)                               
      Clear Cell Focus                                23 (38%)                               16 (31%)                               
      Degeneration, Cystic                             6 (10%)                                3 (6%)                                
      Eosinophilic Focus                               7 (12%)                                6 (12%)                               
      Fatty Change                                     7 (12%)                                1 (2%)                                
      Hepatodiaphragmatic Nodule                       2 (3%)                                 4 (8%)                                
      Inflammation, Granulomatous                      3 (5%)                                                                       
      Inflammation, Necrotizing                        2 (3%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                 3 (6%)                                
      Bile Duct, Hyperplasia                          46 (77%)                               43 (84%)                               
      Centrilobular, Necrosis                          1 (2%)                                 9 (18%)                               
   Mesentery                                          (14)                                   (14)                                   
      Hemorrhage                                       1 (7%)                                                                       
      Fat, Necrosis                                   13 (93%)                                8 (57%)                               
   Pancreas                                           (59)         (10)                      (47)                                   
      Basophilic Focus                                 1 (2%)                                                                       
      Acinus, Atrophy                                 20 (34%)                               10 (21%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Hyperplasia                              6 (10%)                               11 (23%)                               
   Stomach, Forestomach                               (59)         (10)                      (50)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Necrotizing                        4 (7%)                                 5 (10%)                               
      Epithelium, Hyperplasia                                                                 3 (6%)                                
   Stomach, Glandular                                 (59)         (10)                      (49)                                   
      Inflammation, Necrotizing                        2 (3%)                                 7 (14%)                               
      Mineralization                                   2 (3%)                                 4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                              (2)                                    
      Foreign Body                                                                            1 (50%)                               
      Inflammation, Chronic Active                                                            1 (50%)                               
   Heart                                              (60)         (10)                      (50)                                   
      Mineralization                                                                          1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Myocardium, Degeneration, Chronic               55 (92%)      9 (90%)                  46 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)                      (50)                                   
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia                                     20 (33%)                               12 (24%)                               
      Hypertrophy                                      4 (7%)                                 1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (10)                      (50)                                   
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia                                     18 (30%)                               26 (52%)                               
   Islets, Pancreatic                                 (59)         (10)                      (47)                                   
      Hyperplasia                                                                             4 (9%)                                
   Parathyroid Gland                                  (56)         (9)                       (47)                                   
      Hyperplasia                                                                             2 (4%)                                
   Pituitary Gland                                    (58)         (10)                      (51)                                   
      Pars Distalis, Ectasia                                                                  1 (2%)                                
      Pars Distalis, Hyperplasia                      20 (34%)                               13 (25%)                               
   Thyroid Gland                                      (58)         (10)                      (50)                                   
      C-Cell, Hyperplasia                             16 (28%)                                8 (16%)                               
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     2 (3%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (59)         (10)                      (50)                                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                     2 (3%)                                                                       
      Duct, Dilatation                                                                        1 (2%)                                
   Prostate                                           (60)         (10)                      (50)                                   
      Degeneration, Mucoid                             1 (2%)                                                                       
      Dilatation                                                                              1 (2%)                                
      Hyperplasia                                                                             2 (4%)                                
      Inflammation, Chronic Active                     5 (8%)                                11 (22%)                               
   Seminal Vesicle                                    (60)         (10)                      (50)                                   
      Dilatation                                                                              1 (2%)                                
   Testes                                             (60)         (10)                      (49)                                   
      Degeneration                                                                            1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  16 (27%)                                6 (12%)                               
      Seminiferous Tubule, Atrophy                     3 (5%)                                 4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (59)         (10)                      (50)                                   
      Sinus, Ectasia                                   1 (2%)                                                                       
   Spleen                                             (60)         (10)                      (49)                                   
      Fibrosis                                         4 (7%)                                 2 (4%)                                
      Inflammation, Necrotizing                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (10)                      (51)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 2 (4%)                                
      Subcutaneous Tissue, Fibrosis                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)                                    (3)                                    
      Edema                                            1 (33%)                                                                      
      Diaphragm, Hemorrhage, Chronic                   1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                      (50)                                   
      Compression                                      6 (10%)                                3 (6%)                                
      Degeneration                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                      (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Foreign Body                                     3 (5%)                                 2 (4%)                                
      Inflammation, Chronic Active                     9 (15%)      2 (20%)                   2 (4%)                                
      Inflammation, Necrotizing                        5 (8%)                                 2 (4%)                                
      Alveolar Epithelium, Hyperplasia                11 (18%)                               10 (20%)                               
      Mediastinum, Hemorrhage                          1 (2%)                                                                       
   Nose                                               (60)         (10)                      (50)                                   
      Fungus                                           2 (3%)                                                                       
      Mucosa, Inflammation, Suppurative               14 (23%)      1 (10%)                   3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (3)                                    
      Lens, Cataract                                                                          1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (59)         (10)                      
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Nephropathy                                     58 (97%)     10 (100%)                 58 (98%)      8 (80%)                  
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
   Urinary Bladder                                    (60)         (10)                      (50)                                   
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (2%)                                 1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10            9            9            7           
  Early Deaths                                                                                                                      
    Natural Death                                      6                                      8                         2           
    Moribund Sacrifice                                14                                     14                                     
    Dosing Accident                                    5                                      5            1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                                     24                                     
  Animals Examined Microscopically                    60           10                        60            9                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                                   (60)         (9)                       
      Dilatation                                       1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Muscularis, Inflammation, Chronic                                                                    1 (11%)                  
   Intestine Large, Rectum                            (49)                                   (58)         (9)                       
      Parasite Metazoan                                4 (8%)                                 2 (3%)                                
   Intestine Small, Duodenum                          (49)                                   (59)         (9)                       
      Inflammation, Necrotizing                        1 (2%)                                 1 (2%)                                
   Liver                                              (51)                                   (60)         (9)                       
      Basophilic Focus                                25 (49%)                               31 (52%)                               
      Clear Cell Focus                                21 (41%)                               22 (37%)                               
      Degeneration, Cystic                             6 (12%)                                                                      
      Eosinophilic Focus                               3 (6%)                                 7 (12%)                               
      Fatty Change                                     3 (6%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (6%)                                 4 (7%)                                
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Inflammation, Necrotizing                        2 (4%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                 1 (2%)                                
      Bile Duct, Hyperplasia                          42 (82%)                               35 (58%)                               
   Mesentery                                          (7)                                    (8)          (1)                       
      Hemorrhage                                                                              1 (13%)                               
      Inflammation, Granulomatous                                                                          1 (100%)                 
      Fat, Necrosis                                    7 (100%)                               7 (88%)                               
   Pancreas                                           (48)                                   (58)         (9)                       
      Basophilic Focus                                                                        3 (5%)                                
      Acinus, Atrophy                                 12 (25%)                               19 (33%)                               
      Acinus, Hyperplasia                              8 (17%)                               13 (22%)                               
   Salivary Glands                                    (49)                                   (58)         (9)                       
      Inflammation, Chronic Active                                                            2 (3%)                                
   Stomach, Forestomach                               (49)                                   (60)         (9)                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                                                   3 (5%)                                
      Inflammation, Necrotizing                        5 (10%)                                4 (7%)                                
      Mineralization                                                                          1 (2%)                                
      Epithelium, Hyperplasia                          4 (8%)                                 1 (2%)                                
   Stomach, Glandular                                 (49)                                   (59)         (9)                       
      Inflammation, Necrotizing                        4 (8%)                                 6 (10%)                               
      Mineralization                                   2 (4%)                                 9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                                   (60)         (9)                       
      Inflammation, Necrotizing                        1 (2%)                                 1 (2%)                                
      Mineralization                                                                          2 (3%)                                
      Myocardium, Degeneration, Chronic               46 (92%)                               54 (90%)      5 (56%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                                   (60)         (9)                       
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Hyperplasia                                     21 (42%)                               19 (32%)                               
      Hypertrophy                                      3 (6%)                                                                       
   Adrenal Gland, Medulla                             (49)                                   (59)         (9)                       
      Hyperplasia                                     17 (35%)                               20 (34%)                               
   Islets, Pancreatic                                 (48)                                   (59)         (9)                       
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (45)                                   (53)         (8)                       
      Hyperplasia                                      5 (11%)                                8 (15%)                               
   Pituitary Gland                                    (49)                                   (60)         (9)                       
      Pars Distalis, Ectasia                           1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      15 (31%)                               13 (22%)                               
      Pars Nervosa, Hyperplasia, Glandular                                                    1 (2%)                                
   Thyroid Gland                                      (47)                                   (59)         (9)                       
      C-Cell, Hyperplasia                              7 (15%)                               11 (19%)                               
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                     2 (4%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)                                   (60)         (9)                       
      Inflammation, Chronic Active                                                            2 (3%)       1 (11%)                  
      Duct, Dilatation                                 1 (2%)                                                                       
   Prostate                                           (50)                                   (60)         (9)                       
      Inflammation, Chronic Active                     7 (14%)                                7 (12%)                               
   Seminal Vesicle                                    (50)                                   (60)         (9)                       
      Mineralization                                                                          1 (2%)                                
   Testes                                             (51)                                   (60)         (9)                       
      Inflammation, Chronic Active                     1 (2%)                                 3 (5%)                                
      Mineralization                                                                          1 (2%)                                
      Interstitial Cell, Hyperplasia                  13 (25%)                               20 (33%)                               
      Seminiferous Tubule, Atrophy                     3 (6%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (48)                                   (58)         (9)                       
      Edema                                            2 (4%)                                                                       
      Mineralization                                                                          1 (2%)                                
   Spleen                                             (50)                                   (59)         (9)                       
      Fibrosis                                         3 (6%)                                 7 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)                                   (48)         (6)                       
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                                                            2 (4%)                                
   Skin                                               (50)                                   (60)         (9)                       
      Edema                                            1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                                 4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                                   (60)         (9)                       
      Cranium, Fibrous Osteodystrophy                  2 (4%)                                 4 (7%)                                
      Femur, Fibrous Osteodystrophy                    2 (4%)                                 6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                                   (60)         (9)                       
      Compression                                      5 (10%)                                1 (2%)                                
      Degeneration                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                   (60)         (9)                       
      Foreign Body                                     4 (8%)                                 3 (5%)                                
      Inflammation, Chronic Active                     6 (12%)                                4 (7%)       2 (22%)                  
      Inflammation, Necrotizing                        4 (8%)                                 5 (8%)                                
      Mineralization                                                                          2 (3%)                                
      Alveolar Epithelium, Hyperplasia                12 (24%)                               10 (17%)                               
      Mediastinum, Hemorrhage                                                                 1 (2%)                                
   Nose                                               (48)                                   (60)         (9)                       
      Foreign Body                                                                            1 (2%)                                
      Mucosa, Inflammation, Suppurative                7 (15%)                                6 (10%)                               
   Trachea                                            (50)                                   (59)         (9)                       
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                    (2)                                    
      Pinna, Inflammation, Chronic Active                                                     1 (50%)                               
   Eye                                                (1)                                    (7)                                    
      Degeneration                                     1 (100%)                               2 (29%)                               
      Inflammation, Chronic Active                                                            3 (43%)                               
      Cornea, Mineralization                                                                  1 (14%)                               
      Lens, Cataract                                                                          1 (14%)                               
      Retina, Atrophy                                                                         1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (59)         (9)                       
      Mineralization                                                                          3 (5%)                                
      Nephropathy                                     58 (97%)      9 (90%)                  59 (100%)     8 (89%)                  
      Pelvis, Inflammation, Suppurative                                                       1 (2%)                                
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
      Transitional Epithelium, Hyperplasia             2 (3%)                                 1 (2%)                                
   Urinary Bladder                                    (50)                                   (59)         (9)                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.