Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3592

TDMS Study 05086-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                      O-BENZYL-P-CHLOROPHENOL


NTP Experiment-Test: 05086-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: GAVAGE                                                                                                     Time: 06:48:22




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-32-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10           10           10            9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17                                     12                                     
    Dosing Accident                                    2                                      1                                     
    Natural Death                                      5                                      7                         1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                                     30                                     
  Animals Examined Microscopically                    60           10                        60           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (10)                      (50)                                   
      Muscularis, Inflammation, Chronic                             1 (10%)                                                         
   Intestine Large, Colon                             (59)         (10)                      (50)                                   
      Parasite Metazoan                                3 (5%)                                                                       
   Intestine Large, Rectum                            (59)         (10)                      (50)                                   
      Parasite Metazoan                                3 (5%)       1 (10%)                   6 (12%)                               
   Intestine Small, Duodenum                          (60)         (10)                      (50)                                   
      Inflammation, Necrotizing                        2 (3%)                                                                       
   Liver                                              (60)         (10)                      (54)                                   
      Basophilic Focus                                41 (68%)                               43 (80%)                               
      Clear Cell Focus                                 6 (10%)                               10 (19%)                               
      Eosinophilic Focus                               1 (2%)                                 2 (4%)                                
      Fatty Change                                     1 (2%)                                 4 (7%)                                
      Hepatodiaphragmatic Nodule                       8 (13%)                                9 (17%)                               
      Inflammation, Granulomatous                      8 (13%)                                9 (17%)                               
      Mixed Cell Focus                                                                        3 (6%)                                
      Bile Duct, Hyperplasia                          35 (58%)                               37 (69%)                               
      Centrilobular, Necrosis                                                                 3 (6%)                                
   Mesentery                                          (4)                                    (3)                                    
      Fat, Necrosis                                    4 (100%)                               2 (67%)                               
   Pancreas                                           (60)         (10)                      (50)                                   
      Inflammation, Chronic                                         1 (10%)                                                         
      Acinus, Atrophy                                 11 (18%)                               12 (24%)                               
      Acinus, Hyperplasia                              4 (7%)                                 1 (2%)                                
   Pharynx                                                                                   (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
   Salivary Glands                                    (60)         (10)                      (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (10)                      (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Necrotizing                        2 (3%)                                 2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Epithelium, Hyperplasia                          1 (2%)                                 2 (4%)                                
   Stomach, Glandular                                 (59)         (10)                      (50)                                   
      Inflammation, Necrotizing                        1 (2%)                                 3 (6%)                                
      Mineralization                                   3 (5%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (10)                      (50)                                   
      Thrombosis                                                                              1 (2%)                                
      Myocardium, Degeneration, Chronic               40 (67%)      3 (30%)                  43 (86%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)                      (50)                                   
      Hyperplasia                                     15 (25%)                               14 (28%)                               
      Hypertrophy                                      1 (2%)                                 2 (4%)                                
      Necrosis                                         1 (2%)                                 2 (4%)                                
   Adrenal Gland, Medulla                             (60)         (10)                      (50)                                   
      Hyperplasia                                      8 (13%)                                4 (8%)                                
   Islets, Pancreatic                                 (60)         (10)                      (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (56)         (10)                      (44)                                   
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (60)         (10)                      (51)                                   
      Pars Distalis, Ectasia                                                                  1 (2%)                                
      Pars Distalis, Hyperplasia                      27 (45%)                               22 (43%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (60)         (10)                      (50)                                   
      C-Cell, Hyperplasia                             19 (32%)                                8 (16%)                               
      Follicular Cell, Hyperplasia                     5 (8%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (10)                      (48)                                   
      Hyperplasia                                      1 (2%)                                 2 (4%)                                
      Inflammation, Chronic Active                     2 (3%)                                 2 (4%)                                
      Duct, Dilatation                                 1 (2%)                                                                       
   Ovary                                              (60)         (10)                      (52)         (1)                       
      Cyst                                             2 (3%)                                 4 (8%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Periovarian Tissue, Cyst                         1 (2%)                                 1 (2%)                                
   Vagina                                                                                    (1)                                    
      Inflammation, Acute                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                      (50)                                   
      Femoral, Hyperplasia, Reticulum Cell                          1 (10%)                                                         
   Lymph Node, Mesenteric                             (59)         (10)                      (48)                                   
      Edema                                            1 (2%)                                                                       
   Spleen                                             (60)         (10)                      (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
   Thymus                                             (58)         (10)                      (46)                                   
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (9)                       (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Skin                                               (60)         (10)                      (50)                                   
      Inflammation, Chronic Active                     2 (3%)                                 1 (2%)                                
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                    (1)                                    
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                      (50)                                   
      Compression                                      5 (8%)                                 2 (4%)                                
      Developmental Malformation                       1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                      (50)                                   
      Foreign Body                                     1 (2%)                                 2 (4%)                                
      Inflammation, Chronic Active                     8 (13%)      2 (20%)                   1 (2%)                                
      Inflammation, Necrotizing                        2 (3%)                                 1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (7%)                                 8 (16%)                               
   Nose                                               (60)         (10)                      (50)                                   
      Mucosa, Inflammation, Suppurative                2 (3%)                                 3 (6%)                                
      Nasolacrimal Duct, Inflammation, Suppurative                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                       (4)                                    
      Degeneration                                                                            1 (25%)                               
      Lens, Cataract                                                1 (100%)                  2 (50%)                               
      Retina, Atrophy                                               1 (100%)                  1 (25%)                               
   Harderian Gland                                                 (1)                       (1)                                    
      Inflammation, Chronic Active                                  1 (100%)                                                        
   Zymbal's Gland                                                                            (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (60)         (10)                      
      Infarct                                                                                 1 (2%)                                
      Nephropathy                                     55 (92%)      1 (10%)                  57 (95%)      3 (30%)                  
      Corticomedullary Junction, Concretion                         1 (10%)                                                         
      Corticomedullary Junction, Mineralization                     5 (50%)                                6 (60%)                  
      Pelvis, Inflammation, Suppurative                1 (2%)                                                                       
      Pelvis, Mineralization                           3 (5%)                                 2 (3%)                                
   Urinary Bladder                                    (60)         (10)                      (50)                                   
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                  9            8            9           10            9            8           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15                                     18                                     
    Natural Death                                      7                         1            3            1                        
    Dosing Accident                                    1            2                         1                         2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                     28                                     
  Animals Examined Microscopically                    60            8                        60           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (52)                                   (60)         (10)                      
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Inflammation, Necrotizing                                                               1 (2%)                                
      Muscularis, Inflammation, Chronic                                                                    1 (10%)                  
   Intestine Large, Cecum                             (51)                                   (60)         (10)                      
      Inflammation, Necrotizing                                                               1 (2%)                                
   Intestine Large, Rectum                            (51)                                   (60)         (9)                       
      Parasite Metazoan                                3 (6%)                                 1 (2%)                                
   Intestine Small, Duodenum                          (51)                                   (60)         (10)                      
      Inflammation, Necrotizing                                                               1 (2%)                                
   Liver                                              (52)                                   (60)         (10)                      
      Basophilic Focus                                41 (79%)                               43 (72%)                               
      Clear Cell Focus                                 9 (17%)                               16 (27%)                               
      Degeneration, Cystic                             1 (2%)                                 2 (3%)                                
      Eosinophilic Focus                               3 (6%)                                 2 (3%)                                
      Fatty Change                                     1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       9 (17%)                                8 (13%)                               
      Inflammation, Granulomatous                      5 (10%)                                2 (3%)                                
      Inflammation, Necrotizing                        1 (2%)                                 2 (3%)                                
      Bile Duct, Hyperplasia                          33 (63%)                               25 (42%)                               
   Mesentery                                          (1)                                    (5)                                    
      Fibrosis                                         1 (100%)                                                                     
      Hemorrhage                                                                              1 (20%)                               
      Fat, Necrosis                                                                           3 (60%)                               
   Pancreas                                           (50)                                   (60)         (10)                      
      Acinus, Atrophy                                  8 (16%)                               16 (27%)                               
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Salivary Glands                                    (50)                                   (60)         (10)                      
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (52)                                   (60)         (10)                      
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                                                                   2 (3%)                                
      Inflammation, Necrotizing                        1 (2%)                                 5 (8%)                                
   Stomach, Glandular                                 (51)                                   (60)         (10)                      
      Inflammation, Necrotizing                                                               3 (5%)                                
      Mineralization                                                                          2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (51)                                   (60)         (10)                      
      Mineralization                                                                          1 (2%)                                
      Myocardium, Degeneration, Chronic               42 (82%)                               44 (73%)      2 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (51)                                   (60)         (10)                      
      Hyperplasia                                     10 (20%)                               26 (43%)                               
      Hypertrophy                                      4 (8%)                                 2 (3%)                                
      Necrosis                                         1 (2%)                                                                       
   Adrenal Gland, Medulla                             (51)                                   (60)         (10)                      
      Hyperplasia                                      3 (6%)                                10 (17%)                               
   Parathyroid Gland                                  (46)                                   (57)         (8)                       
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (51)                                   (60)         (10)                      
      Pars Distalis, Ectasia                                                                  1 (2%)                                
      Pars Distalis, Hyperplasia                      30 (59%)                               28 (47%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (51)                                   (60)         (10)                      
      C-Cell, Hyperplasia                             11 (22%)                               22 (37%)                               
      Follicular Cell, Hyperplasia                     1 (2%)                                 4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)                                   (56)         (10)                      
      Hyperplasia                                      5 (10%)                                1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Duct, Dilatation                                 2 (4%)                                                                       
   Ovary                                              (51)                                   (60)         (10)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             3 (6%)                                 1 (2%)                                
   Uterus                                             (53)                                   (60)         (10)                      
      Dilatation                                       2 (4%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (51)                                   (60)         (10)                      
      Femoral, Hyperplasia, Reticulum Cell                                                                 1 (10%)                  
   Lymph Node                                         (51)                                   (60)         (10)                      
      Mediastinal, Edema                               1 (2%)                                                                       
   Spleen                                             (51)                                   (60)         (10)                      
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                   (60)         (10)                      
      Hyperplasia                                      2 (4%)                                                                       
   Skin                                               (50)                                   (60)         (10)                      
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (51)                                   (60)         (10)                      
      Compression                                      1 (2%)                                 6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)                                   (59)         (10)                      
      Inflammation, Chronic Active                     1 (2%)                                 4 (7%)       2 (20%)                  
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Mineralization                                                                          2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 7 (12%)                               
   Nose                                               (51)                                   (60)         (10)                      
      Mucosa, Inflammation, Suppurative                6 (12%)                                4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (1)                       (6)          (1)                       
      Degeneration                                     2 (29%)                                3 (50%)                               
      Inflammation, Chronic Active                                                            2 (33%)                               
      Lens, Cataract                                   3 (43%)      1 (100%)                  1 (17%)      1 (100%)                 
      Retina, Atrophy                                  3 (43%)                                             1 (100%)                 
   Harderian Gland                                    (1)                                                 (1)                       
      Inflammation, Chronic Active                     1 (100%)                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (8)                       (60)         (10)                      
      Atrophy                                                                                 1 (2%)                                
      Calculus Micro Observation Only                                                         2 (3%)                                
      Mineralization                                                                          1 (2%)                                
      Nephropathy                                     59 (98%)      3 (38%)                  60 (100%)     7 (70%)                  
      Corticomedullary Junction, Mineralization                     3 (38%)                                1 (10%)                  
      Pelvis, Inflammation, Suppurative                1 (2%)                                 2 (3%)                                
      Pelvis, Mineralization                           2 (3%)                                16 (27%)                               
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
   Urinary Bladder                                    (51)                                   (60)         (10)                      
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16                                     13                                     
    Natural Death                                      5                                     11                                     
    Dosing Accident                                    6                                      2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23                                     24                                     
  Animals Examined Microscopically                    60           10                        60           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (10)                      (50)                                   
      Foreign Body                                     2 (3%)                                                                       
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Muscularis, Inflammation, Chronic                             2 (20%)                                                         
   Intestine Large, Cecum                             (58)         (10)                      (48)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
   Intestine Large, Colon                             (60)         (10)                      (50)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Rectum                            (60)         (10)                      (49)                                   
      Parasite Metazoan                                2 (3%)       1 (10%)                   7 (14%)                               
   Intestine Small, Jejunum                           (59)         (10)                      (48)                                   
      Inflammation, Necrotizing                        1 (2%)                                                                       
   Liver                                              (60)         (10)                      (51)                                   
      Basophilic Focus                                35 (58%)                               33 (65%)                               
      Clear Cell Focus                                23 (38%)                               16 (31%)                               
      Degeneration, Cystic                             6 (10%)                                3 (6%)                                
      Eosinophilic Focus                               7 (12%)                                6 (12%)                               
      Fatty Change                                     7 (12%)                                1 (2%)                                
      Hepatodiaphragmatic Nodule                       2 (3%)                                 4 (8%)                                
      Inflammation, Granulomatous                      3 (5%)                                                                       
      Inflammation, Necrotizing                        2 (3%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                 3 (6%)                                
      Bile Duct, Hyperplasia                          46 (77%)                               43 (84%)                               
      Centrilobular, Necrosis                          1 (2%)                                 9 (18%)                               
   Mesentery                                          (14)                                   (14)                                   
      Hemorrhage                                       1 (7%)                                                                       
      Fat, Necrosis                                   13 (93%)                                8 (57%)                               
   Pancreas                                           (59)         (10)                      (47)                                   
      Basophilic Focus                                 1 (2%)                                                                       
      Acinus, Atrophy                                 20 (34%)                               10 (21%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Hyperplasia                              6 (10%)                               11 (23%)                               
   Stomach, Forestomach                               (59)         (10)                      (50)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Necrotizing                        4 (7%)                                 5 (10%)                               
      Epithelium, Hyperplasia                                                                 3 (6%)                                
   Stomach, Glandular                                 (59)         (10)                      (49)                                   
      Inflammation, Necrotizing                        2 (3%)                                 7 (14%)                               
      Mineralization                                   2 (3%)                                 4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                              (2)                                    
      Foreign Body                                                                            1 (50%)                               
      Inflammation, Chronic Active                                                            1 (50%)                               
   Heart                                              (60)         (10)                      (50)                                   
      Mineralization                                                                          1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Myocardium, Degeneration, Chronic               55 (92%)      9 (90%)                  46 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)                      (50)                                   
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia                                     20 (33%)                               12 (24%)                               
      Hypertrophy                                      4 (7%)                                 1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (10)                      (50)                                   
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia                                     18 (30%)                               26 (52%)                               
   Islets, Pancreatic                                 (59)         (10)                      (47)                                   
      Hyperplasia                                                                             4 (9%)                                
   Parathyroid Gland                                  (56)         (9)                       (47)                                   
      Hyperplasia                                                                             2 (4%)                                
   Pituitary Gland                                    (58)         (10)                      (51)                                   
      Pars Distalis, Ectasia                                                                  1 (2%)                                
      Pars Distalis, Hyperplasia                      20 (34%)                               13 (25%)                               
   Thyroid Gland                                      (58)         (10)                      (50)                                   
      C-Cell, Hyperplasia                             16 (28%)                                8 (16%)                               
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     2 (3%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (59)         (10)                      (50)                                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                     2 (3%)                                                                       
      Duct, Dilatation                                                                        1 (2%)                                
   Prostate                                           (60)         (10)                      (50)                                   
      Degeneration, Mucoid                             1 (2%)                                                                       
      Dilatation                                                                              1 (2%)                                
      Hyperplasia                                                                             2 (4%)                                
      Inflammation, Chronic Active                     5 (8%)                                11 (22%)                               
   Seminal Vesicle                                    (60)         (10)                      (50)                                   
      Dilatation                                                                              1 (2%)                                
   Testes                                             (60)         (10)                      (49)                                   
      Degeneration                                                                            1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  16 (27%)                                6 (12%)                               
      Seminiferous Tubule, Atrophy                     3 (5%)                                 4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (59)         (10)                      (50)                                   
      Sinus, Ectasia                                   1 (2%)                                                                       
   Spleen                                             (60)         (10)                      (49)                                   
      Fibrosis                                         4 (7%)                                 2 (4%)                                
      Inflammation, Necrotizing                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (10)                      (51)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 2 (4%)                                
      Subcutaneous Tissue, Fibrosis                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)                                    (3)                                    
      Edema                                            1 (33%)                                                                      
      Diaphragm, Hemorrhage, Chronic                   1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                      (50)                                   
      Compression                                      6 (10%)                                3 (6%)                                
      Degeneration                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                      (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Foreign Body                                     3 (5%)                                 2 (4%)                                
      Inflammation, Chronic Active                     9 (15%)      2 (20%)                   2 (4%)                                
      Inflammation, Necrotizing                        5 (8%)                                 2 (4%)                                
      Alveolar Epithelium, Hyperplasia                11 (18%)                               10 (20%)                               
      Mediastinum, Hemorrhage                          1 (2%)                                                                       
   Nose                                               (60)         (10)                      (50)                                   
      Fungus                                           2 (3%)                                                                       
      Mucosa, Inflammation, Suppurative               14 (23%)      1 (10%)                   3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (3)                                    
      Lens, Cataract                                                                          1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (59)         (10)                      
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Nephropathy                                     58 (97%)     10 (100%)                 58 (98%)      8 (80%)                  
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
   Urinary Bladder                                    (60)         (10)                      (50)                                   
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (2%)                                 1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10            9            9            7           
  Early Deaths                                                                                                                      
    Natural Death                                      6                                      8                         2           
    Moribund Sacrifice                                14                                     14                                     
    Dosing Accident                                    5                                      5            1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                                     24                                     
  Animals Examined Microscopically                    60           10                        60            9                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                                   (60)         (9)                       
      Dilatation                                       1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Muscularis, Inflammation, Chronic                                                                    1 (11%)                  
   Intestine Large, Rectum                            (49)                                   (58)         (9)                       
      Parasite Metazoan                                4 (8%)                                 2 (3%)                                
   Intestine Small, Duodenum                          (49)                                   (59)         (9)                       
      Inflammation, Necrotizing                        1 (2%)                                 1 (2%)                                
   Liver                                              (51)                                   (60)         (9)                       
      Basophilic Focus                                25 (49%)                               31 (52%)                               
      Clear Cell Focus                                21 (41%)                               22 (37%)                               
      Degeneration, Cystic                             6 (12%)                                                                      
      Eosinophilic Focus                               3 (6%)                                 7 (12%)                               
      Fatty Change                                     3 (6%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (6%)                                 4 (7%)                                
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Inflammation, Necrotizing                        2 (4%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                 1 (2%)                                
      Bile Duct, Hyperplasia                          42 (82%)                               35 (58%)                               
   Mesentery                                          (7)                                    (8)          (1)                       
      Hemorrhage                                                                              1 (13%)                               
      Inflammation, Granulomatous                                                                          1 (100%)                 
      Fat, Necrosis                                    7 (100%)                               7 (88%)                               
   Pancreas                                           (48)                                   (58)         (9)                       
      Basophilic Focus                                                                        3 (5%)                                
      Acinus, Atrophy                                 12 (25%)                               19 (33%)                               
      Acinus, Hyperplasia                              8 (17%)                               13 (22%)                               
   Salivary Glands                                    (49)                                   (58)         (9)                       
      Inflammation, Chronic Active                                                            2 (3%)                                
   Stomach, Forestomach                               (49)                                   (60)         (9)                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                                                   3 (5%)                                
      Inflammation, Necrotizing                        5 (10%)                                4 (7%)                                
      Mineralization                                                                          1 (2%)                                
      Epithelium, Hyperplasia                          4 (8%)                                 1 (2%)                                
   Stomach, Glandular                                 (49)                                   (59)         (9)                       
      Inflammation, Necrotizing                        4 (8%)                                 6 (10%)                               
      Mineralization                                   2 (4%)                                 9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                                   (60)         (9)                       
      Inflammation, Necrotizing                        1 (2%)                                 1 (2%)                                
      Mineralization                                                                          2 (3%)                                
      Myocardium, Degeneration, Chronic               46 (92%)                               54 (90%)      5 (56%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                                   (60)         (9)                       
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Hyperplasia                                     21 (42%)                               19 (32%)                               
      Hypertrophy                                      3 (6%)                                                                       
   Adrenal Gland, Medulla                             (49)                                   (59)         (9)                       
      Hyperplasia                                     17 (35%)                               20 (34%)                               
   Islets, Pancreatic                                 (48)                                   (59)         (9)                       
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (45)                                   (53)         (8)                       
      Hyperplasia                                      5 (11%)                                8 (15%)                               
   Pituitary Gland                                    (49)                                   (60)         (9)                       
      Pars Distalis, Ectasia                           1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      15 (31%)                               13 (22%)                               
      Pars Nervosa, Hyperplasia, Glandular                                                    1 (2%)                                
   Thyroid Gland                                      (47)                                   (59)         (9)                       
      C-Cell, Hyperplasia                              7 (15%)                               11 (19%)                               
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                     2 (4%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)                                   (60)         (9)                       
      Inflammation, Chronic Active                                                            2 (3%)       1 (11%)                  
      Duct, Dilatation                                 1 (2%)                                                                       
   Prostate                                           (50)                                   (60)         (9)                       
      Inflammation, Chronic Active                     7 (14%)                                7 (12%)                               
   Seminal Vesicle                                    (50)                                   (60)         (9)                       
      Mineralization                                                                          1 (2%)                                
   Testes                                             (51)                                   (60)         (9)                       
      Inflammation, Chronic Active                     1 (2%)                                 3 (5%)                                
      Mineralization                                                                          1 (2%)                                
      Interstitial Cell, Hyperplasia                  13 (25%)                               20 (33%)                               
      Seminiferous Tubule, Atrophy                     3 (6%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (48)                                   (58)         (9)                       
      Edema                                            2 (4%)                                                                       
      Mineralization                                                                          1 (2%)                                
   Spleen                                             (50)                                   (59)         (9)                       
      Fibrosis                                         3 (6%)                                 7 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)                                   (48)         (6)                       
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                                                            2 (4%)                                
   Skin                                               (50)                                   (60)         (9)                       
      Edema                                            1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                                 4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                                   (60)         (9)                       
      Cranium, Fibrous Osteodystrophy                  2 (4%)                                 4 (7%)                                
      Femur, Fibrous Osteodystrophy                    2 (4%)                                 6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                                   (60)         (9)                       
      Compression                                      5 (10%)                                1 (2%)                                
      Degeneration                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05086-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                   (60)         (9)                       
      Foreign Body                                     4 (8%)                                 3 (5%)                                
      Inflammation, Chronic Active                     6 (12%)                                4 (7%)       2 (22%)                  
      Inflammation, Necrotizing                        4 (8%)                                 5 (8%)                                
      Mineralization                                                                          2 (3%)                                
      Alveolar Epithelium, Hyperplasia                12 (24%)                               10 (17%)                               
      Mediastinum, Hemorrhage                                                                 1 (2%)                                
   Nose                                               (48)                                   (60)         (9)                       
      Foreign Body                                                                            1 (2%)                                
      Mucosa, Inflammation, Suppurative                7 (15%)                                6 (10%)                               
   Trachea                                            (50)                                   (59)         (9)                       
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                    (2)                                    
      Pinna, Inflammation, Chronic Active                                                     1 (50%)                               
   Eye                                                (1)                                    (7)                                    
      Degeneration                                     1 (100%)                               2 (29%)                               
      Inflammation, Chronic Active                                                            3 (43%)                               
      Cornea, Mineralization                                                                  1 (14%)                               
      Lens, Cataract                                                                          1 (14%)                               
      Retina, Atrophy                                                                         1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (59)         (9)                       
      Mineralization                                                                          3 (5%)                                
      Nephropathy                                     58 (97%)      9 (90%)                  59 (100%)     8 (89%)                  
      Pelvis, Inflammation, Suppurative                                                       1 (2%)                                
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
      Transitional Epithelium, Hyperplasia             2 (3%)                                 1 (2%)                                
   Urinary Bladder                                    (50)                                   (59)         (9)                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------