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https://ntp.niehs.nih.gov/go/3596

TDMS Study 05086-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                      O-BENZYL-P-CHLOROPHENOL


NTP Experiment-Test: 05086-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: GAVAGE                                                                                                     Time: 06:48:24




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-32-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10           10           10            9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17                                     12                                     
    Dosing Accident                                    2                                      1                                     
    Natural Death                                      5                                      7                         1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                                     30                                     
  Animals Examined Microscopically                    60           10                        60           10                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (60)         (10)                      (54)                                   
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (4)                                    (3)                                    
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (33%)                               
   Pancreas                                           (60)         (10)                      (50)                                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (10)                      (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)                      (50)                                   
   Adrenal Gland, Medulla                             (60)         (10)                      (50)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                                                                 3 (6%)                                
   Pituitary Gland                                    (60)         (10)                      (51)                                   
      Craniopharyngioma                                1 (2%)                                                                       
      Pars Distalis, Adenoma                          17 (28%)                               14 (27%)                               
      Pars Distalis, Adenoma, Multiple                 3 (5%)                                                                       
      Pars Distalis, Carcinoma                         2 (3%)                                                                       
   Thyroid Gland                                      (60)         (10)                      (50)                                   
      C-Cell, Adenoma                                  9 (15%)                                6 (12%)                               
      C-Cell, Carcinoma                                1 (2%)                                 1 (2%)                                
      Follicular Cell, Adenoma                         3 (5%)                                 1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (10)                      (48)                                   
      Adenoma                                          7 (12%)                                7 (15%)                               
      Carcinoma                                        5 (8%)                                 2 (4%)                                
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (60)         (10)                      (52)         (1)                       
   Uterus                                             (60)         (10)                      (50)                                   
      Leiomyoma                                                                               1 (2%)                                
      Polyp Stromal                                    4 (7%)                                 5 (10%)                               
      Polyp Stromal, Multiple                          1 (2%)                                 1 (2%)                                
      Sarcoma Stromal                                  2 (3%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                      (50)                                   
   Lymph Node                                         (60)         (10)                      (50)                                   
   Lymph Node, Mandibular                             (60)         (10)                      (50)                                   
      Squamous Cell Carcinoma, Metastatic, Nose                                               1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (10)                      (48)                                   
   Spleen                                             (60)         (10)                      (50)                                   
   Thymus                                             (58)         (10)                      (46)                                   
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (9)                       (50)                                   
      Adenocarcinoma                                   2 (3%)                                                                       
      Adenoma                                                                                 2 (4%)                                
      Fibroadenoma                                    13 (22%)                               10 (20%)                               
      Fibroadenoma, Multiple                                                                  3 (6%)                                
   Skin                                               (60)         (10)                      (50)                                   
      Keratoacanthoma                                                                         1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)                      (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                      (50)                                   
      Carcinoma, Metastatic, Pituitary Gland           2 (3%)                                                                       
      Oligodendroglioma Benign                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                      (50)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Nose                                               (60)         (10)                      (50)                                   
      Nasolacrimal Duct, Squamous Cell Carcinoma                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                       (4)                                    
      Lids, Squamous Cell Carcinoma, Metastatic,                                                                                    
           Nose                                                                               1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (60)         (10)                      
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (2%)                                
   Urinary Bladder                                    (60)         (10)                      (50)                                   
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)                     *(60)        *(10)                      
      Leukemia Mononuclear                            14 (23%)                               16 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0MG/KG       0MG/KG       0MG/KG       60MG/KG      60MG/KG      60MG/KG         
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45                                  40                                       
     Total Primary Neoplasms                           93                                  79                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37                                  33                                       
     Total Benign Neoplasms                            64                                  55                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24                                  19                                       
     Total Malignant Neoplasms                         29                                  24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                                   3                                       
     Total Metastatic Neoplasm                          3                                   6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                  9            8            9           10            9            8           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15                                     18                                     
    Natural Death                                      7                         1            3            1                        
    Dosing Accident                                    1            2                         1                         2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                     28                                     
  Animals Examined Microscopically                    60            8                        60           10                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (52)                                   (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Intestine Large, Rectum                            (51)                                   (60)         (9)                       
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Liver                                              (52)                                   (60)         (10)                      
   Mesentery                                          (1)                                    (5)                                    
      Liposarcoma                                                                             1 (20%)                               
   Pancreas                                           (50)                                   (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Stomach, Glandular                                 (51)                                   (60)         (10)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (51)                                   (60)         (10)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (51)                                   (60)         (10)                      
   Adrenal Gland, Medulla                             (51)                                   (60)         (10)                      
      Pheochromocytoma Benign                          3 (6%)                                 4 (7%)                                
   Islets, Pancreatic                                 (50)                                   (60)         (10)                      
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (51)                                   (60)         (10)                      
      Pars Distalis, Adenoma                          13 (25%)                               19 (32%)                               
   Thyroid Gland                                      (51)                                   (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Bilateral, C-Cell, Adenoma                                                              1 (2%)                                
                                                             Page   6                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                  6 (12%)                                6 (10%)                               
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                                                                2 (3%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)                                   (56)         (10)                      
      Adenoma                                          4 (8%)                                 3 (5%)                                
      Carcinoma                                        2 (4%)                                 2 (4%)                                
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Bilateral, Adenoma                                                                      1 (2%)                                
   Ovary                                              (51)                                   (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Uterus                                             (53)                                   (60)         (10)                      
      Polyp Stromal                                    3 (6%)                                11 (18%)                               
      Polyp Stromal, Multiple                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (51)                                   (60)         (10)                      
   Lymph Node                                         (51)                                   (60)         (10)                      
   Lymph Node, Mandibular                             (50)                                   (59)         (10)                      
   Lymph Node, Mesenteric                             (51)                                   (60)         (10)                      
   Spleen                                             (51)                                   (60)         (10)                      
   Thymus                                             (46)                                   (58)         (10)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                   (60)         (10)                      
      Adenocarcinoma                                   1 (2%)                                 2 (3%)                                
      Fibroadenoma                                    15 (30%)                               18 (30%)                               
      Fibroadenoma, Multiple                           2 (4%)                                 3 (5%)                                
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Skin                                               (50)                                   (60)         (10)                      
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                                                            1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
                                                             Page   7                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (51)                                   (60)         (10)                      
      Astrocytoma Benign                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)                                   (59)         (10)                      
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Mediastinum, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skin                             1 (2%)                                                                       
   Trachea                                            (51)                                   (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (8)                       (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Renal Tubule, Adenoma                                                                   1 (2%)                                
      Transitional Epithelium, Carcinoma               1 (2%)                                 1 (2%)                                
   Urinary Bladder                                    (51)                                   (60)         (10)                      
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(8)                      *(60)        *(10)                      
      Leukemia Mononuclear                            11 (18%)                               17 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   120MG/KG     120MG/KG     120MG/KG     240MG/KG     240MG/KG     240MG/KG        
                                                      F         13HUCC F     65HUCC F        F         13HUCC F     65HUCC F        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42                                  50                                       
     Total Primary Neoplasms                           68                                  98                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34                                  44                                       
     Total Benign Neoplasms                            49                                  73                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17                                  22                                       
     Total Malignant Neoplasms                         19                                  25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                   1                                       
     Total Metastatic Neoplasm                         11                                   1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16                                     13                                     
    Natural Death                                      5                                     11                                     
    Dosing Accident                                    6                                      2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23                                     24                                     
  Animals Examined Microscopically                    60           10                        60           10                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (10)                      (50)                                   
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                                        1 (2%)                                
      Polyp Adenomatous                                                                       1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Intestine Small, Jejunum                           (59)         (10)                      (48)                                   
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                                        1 (2%)                                
   Liver                                              (60)         (10)                      (51)                                   
      Hepatocellular Adenoma                                                                  1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Mesentery                                          (14)                                   (14)                                   
      Hemangioma                                                                              1 (7%)                                
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                                        1 (7%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (7%)                                
   Pancreas                                           (59)         (10)                      (47)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Acinus, Adenoma                                  1 (2%)                                                                       
      Acinus, Adenoma, Multiple                                                               1 (2%)                                
   Stomach, Forestomach                               (59)         (10)                      (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (10)                      (49)                                   
   Tooth                                                                                     (1)                                    
      Mixed Tumor NOS                                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (10)                      (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)                      (50)                                   
   Adrenal Gland, Medulla                             (60)         (10)                      (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                 1 (2%)                                
      Pheochromocytoma Benign                         12 (20%)                                7 (14%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (59)         (10)                      (47)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                        2 (3%)                                                                       
   Parathyroid Gland                                  (56)         (9)                       (47)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (58)         (10)                      (51)                                   
      Pars Distalis, Adenoma                          18 (31%)                               12 (24%)                               
      Pars Distalis, Carcinoma                         2 (3%)                                                                       
   Thyroid Gland                                      (58)         (10)                      (50)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  8 (14%)                               10 (20%)                               
      C-Cell, Carcinoma                                3 (5%)                                                                       
      Follicular Cell, Adenoma                         2 (3%)                                 1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (10)                      (49)                                   
   Preputial Gland                                    (59)         (10)                      (50)                                   
      Adenoma                                          7 (12%)                                4 (8%)                                
      Carcinoma                                        2 (3%)                                 3 (6%)                                
   Seminal Vesicle                                    (60)         (10)                      (50)                                   
   Testes                                             (60)         (10)                      (49)                                   
      Sertoli Cell Tumor Benign                        1 (2%)                                                                       
      Bilateral, Interstitial Cell, Adenoma           35 (58%)                               33 (67%)                               
      Interstitial Cell, Adenoma                      10 (17%)                                9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                      (50)                                   
   Lymph Node                                         (60)         (10)                      (50)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (2%)                                                                       
      Mediastinal, Carcinoma Adenosquamous,                                                                                         
          Metastatic, Lung                             1 (2%)                                                                       
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                                        1 (2%)                                
   Lymph Node, Mandibular                             (59)         (10)                      (50)                                   
   Lymph Node, Mesenteric                             (59)         (10)                      (48)                                   
   Spleen                                             (60)         (10)                      (49)                                   
      Fibrosarcoma                                                                            1 (2%)                                
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                                        1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Thymus                                             (54)         (10)                      (46)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (5)                       (44)                                   
      Fibroadenoma                                     2 (5%)                                 2 (5%)                                
   Skin                                               (59)         (10)                      (51)                                   
      Basosquamous Tumor Malignant                     1 (2%)                                 1 (2%)                                
      Keratoacanthoma                                  6 (10%)                                4 (8%)                                
      Squamous Cell Papilloma                                                                 5 (10%)                               
      Subcutaneous Tissue, Fibroma                     1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)                                    (3)                                    
      Chordoma                                                                                1 (33%)                               
      Fibrosarcoma                                     1 (33%)                                                                      
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                                        1 (33%)                               
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                      (50)                                   
      Astrocytoma Benign                               1 (2%)                                                                       
      Astrocytoma Malignant                                                                   1 (2%)                                
      Carcinoma, Metastatic, Pituitary Gland           2 (3%)                                                                       
   Peripheral Nerve                                   (2)                                    (1)                                    
      Schwannoma Benign                                                                       1 (100%)                              
   Spinal Cord                                        (3)                                                                           
      Chordoma                                         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                      (50)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)                                                                       
      Carcinoma Adenosquamous                          1 (2%)                                                                       
      Chordoma, Metastatic, Spinal Cord                1 (2%)                                                                       
      Chordoma, Metastatic, Uncertain Primary Site     1 (2%)                                                                       
   Nose                                               (60)         (10)                      (50)                                   
      Papilloma                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Pinna, Squamous Cell Papilloma                   1 (100%)                                                                     
   Zymbal's Gland                                                                            (1)                                    
      Adenoma                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (59)         (10)                      
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (60)         (10)                      (50)                                   
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)                     *(60)        *(10)                      
      Leukemia Mononuclear                            10 (17%)                                9 (15%)                               
      Mesothelioma Benign                              4 (7%)                                 1 (2%)                                
      Mesothelioma Malignant                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  13                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0MG/KG       0MG/KG       0MG/KG       30MG/KG      30MG/KG      30MG/KG         
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            54                                  52                                       
     Total Primary Neoplasms                          144                                 121                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 53                                  52                                       
     Total Benign Neoplasms                           114                                 100                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24                                  18                                       
     Total Malignant Neoplasms                         30                                  20                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6                                   2                                       
     Total Metastatic Neoplasm                          6                                  12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                   2                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  14                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           10           60           10           10           
  Scheduled Sacrifice                                 10           10           10            9            9            7           
  Early Deaths                                                                                                                      
    Natural Death                                      6                                      8                         2           
    Moribund Sacrifice                                14                                     14                                     
    Dosing Accident                                    5                                      5            1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                                     24                                     
  Animals Examined Microscopically                    60           10                        60            9                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)                                   (60)         (9)                       
      Carcinoma                                        1 (2%)                                                                       
   Intestine Large, Cecum                             (49)                                   (57)         (9)                       
   Intestine Large, Colon                             (49)                                   (59)         (9)                       
   Intestine Large, Rectum                            (49)                                   (58)         (9)                       
   Intestine Small, Duodenum                          (49)                                   (59)         (9)                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Intestine Small, Jejunum                           (48)                                   (59)         (9)                       
      Adenocarcinoma                                   1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (51)                                   (60)         (9)                       
      Hepatocellular Adenoma                                                                  1 (2%)                                
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Mesentery                                          (7)                                    (8)          (1)                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (14%)                                                                      
   Pancreas                                           (48)                                   (58)         (9)                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Acinus, Adenoma                                  2 (4%)                                                                       
      Acinus, Adenoma, Multiple                                                               1 (2%)                                
   Pharynx                                                                                   (1)                                    
      Palate, Squamous Cell Papilloma                                                         1 (100%)                              
   Salivary Glands                                    (49)                                   (58)         (9)                       
   Stomach, Forestomach                               (49)                                   (60)         (9)                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (49)                                   (59)         (9)                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  15                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                                   (60)         (9)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                                   (60)         (9)                       
      Adenoma                                          1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)                                   (59)         (9)                       
      Pheochromocytoma Malignant                       1 (2%)                                 1 (2%)                                
      Pheochromocytoma Benign                          6 (12%)                                9 (15%)                               
      Bilateral, Pheochromocytoma Malignant                                                   1 (2%)                                
      Bilateral, Pheochromocytoma Benign               3 (6%)                                 4 (7%)                                
   Islets, Pancreatic                                 (48)                                   (59)         (9)                       
      Carcinoma                                        2 (4%)                                 2 (3%)                                
   Pituitary Gland                                    (49)                                   (60)         (9)                       
      Pars Distalis, Adenoma                          18 (37%)                               13 (22%)                               
   Thyroid Gland                                      (47)                                   (59)         (9)                       
      Bilateral, C-Cell, Carcinoma                     1 (2%)                                                                       
      C-Cell, Adenoma                                  5 (11%)                                4 (7%)                                
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)                                   (60)         (9)                       
      Adenoma                                          2 (4%)                                 2 (3%)                                
      Carcinoma                                        3 (6%)                                                                       
   Prostate                                           (50)                                   (60)         (9)                       
   Seminal Vesicle                                    (50)                                   (60)         (9)                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Testes                                             (51)                                   (60)         (9)                       
      Bilateral, Interstitial Cell, Adenoma           29 (57%)                               32 (53%)                               
      Interstitial Cell, Adenoma                      10 (20%)                               14 (23%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  16                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)                                   (60)         (9)                       
   Lymph Node                                         (50)                                   (59)         (9)                       
      Mediastinal, Carcinoma, Metastatic,                                                                                           
          Uncertain Primary Site                       1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)                                   (58)         (9)                       
   Lymph Node, Mesenteric                             (50)                                   (57)         (5)                       
   Spleen                                             (50)                                   (59)         (9)                       
   Thymus                                             (48)                                   (55)         (9)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)                                   (48)         (6)                       
      Fibroadenoma                                     2 (5%)                                 1 (2%)                                
   Skin                                               (50)                                   (60)         (9)                       
      Basal Cell Adenoma                                                                      1 (2%)                                
      Basal Cell Adenoma, Multiple                     1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)                                 1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                                 2 (3%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                                   (60)         (9)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                   (60)         (9)                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Carcinoma, Multiple,                                                                                            
                                                             Page  17                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Metastatic, Uncertain Primary Site           1 (2%)                                                                       
      Mediastinum, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                    (2)                                    
      Pinna, Squamous Cell Papilloma                                                          1 (50%)                               
   Zymbal's Gland                                     (1)                                    (2)                                    
      Adenoma                                                                                 1 (50%)                               
      Carcinoma                                        1 (100%)                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                      (59)         (9)                       
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (50)                                   (59)         (9)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)                     *(60)        *(9)                       
      Leukemia Mononuclear                            10 (17%)                               10 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  18                                                               
NTP Experiment-Test: 05086-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      O-BENZYL-P-CHLOROPHENOL                                  Date: 09/11/94  
Route: GAVAGE                                                                                                     Time: 06:48:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     60MG/KG      60MG/KG      60MG/KG      120MG/KG     120MG/KG     120MG/KG        
                                                      M         13HUCC M     65HUCC M        M         13HUCC M     65HUCC M        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45                                  49                                       
     Total Primary Neoplasms                          115                                 107                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44                                  49                                       
     Total Benign Neoplasms                            86                                  90                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22                                  15                                       
     Total Malignant Neoplasms                         29                                  17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                                   1                                       
     Total Metastatic Neoplasm                         13                                   1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               2                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  19                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------