TDMS Study 05086-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
O-BENZYL-P-CHLOROPHENOL
NTP Experiment-Test: 05086-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/11/94
Route: GAVAGE Time: 06:48:24
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-32-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 10 60 10 10
Scheduled Sacrifice 10 10 10 10 10 9
Early Deaths
Moribund Sacrifice 17 12
Dosing Accident 2 1
Natural Death 5 7 1
Survivors
Terminal Sacrifice 26 30
Animals Examined Microscopically 60 10 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (60) (10) (54)
Hepatocellular Adenoma 1 (2%)
Mesentery (4) (3)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (33%)
Pancreas (60) (10) (50)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (10) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50)
Adrenal Gland, Medulla (60) (10) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 3 (6%)
Pituitary Gland (60) (10) (51)
Craniopharyngioma 1 (2%)
Pars Distalis, Adenoma 17 (28%) 14 (27%)
Pars Distalis, Adenoma, Multiple 3 (5%)
Pars Distalis, Carcinoma 2 (3%)
Thyroid Gland (60) (10) (50)
C-Cell, Adenoma 9 (15%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 3 (5%) 1 (2%)
Page 2
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (10) (48)
Adenoma 7 (12%) 7 (15%)
Carcinoma 5 (8%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Ovary (60) (10) (52) (1)
Uterus (60) (10) (50)
Leiomyoma 1 (2%)
Polyp Stromal 4 (7%) 5 (10%)
Polyp Stromal, Multiple 1 (2%) 1 (2%)
Sarcoma Stromal 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50)
Lymph Node (60) (10) (50)
Lymph Node, Mandibular (60) (10) (50)
Squamous Cell Carcinoma, Metastatic, Nose 1 (2%)
Lymph Node, Mesenteric (59) (10) (48)
Spleen (60) (10) (50)
Thymus (58) (10) (46)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (9) (50)
Adenocarcinoma 2 (3%)
Adenoma 2 (4%)
Fibroadenoma 13 (22%) 10 (20%)
Fibroadenoma, Multiple 3 (6%)
Skin (60) (10) (50)
Keratoacanthoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10) (50)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (60) (10) (50)
Nasolacrimal Duct, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (4)
Lids, Squamous Cell Carcinoma, Metastatic,
Nose 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (60) (10)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Urinary Bladder (60) (10) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10) *(60) *(10)
Leukemia Mononuclear 14 (23%) 16 (27%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 40
Total Primary Neoplasms 93 79
Total Animals with Benign Neoplasms 37 33
Total Benign Neoplasms 64 55
Total Animals with Malignant Neoplasms 24 19
Total Malignant Neoplasms 29 24
Total Animals with Metastatic Neoplasms 3 3
Total Metastatic Neoplasm 3 6
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 10 60 10 10
Scheduled Sacrifice 9 8 9 10 9 8
Early Deaths
Moribund Sacrifice 15 18
Natural Death 7 1 3 1
Dosing Accident 1 2 1 2
Survivors
Terminal Sacrifice 28 28
Animals Examined Microscopically 60 8 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (52) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Intestine Large, Rectum (51) (60) (9)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Liver (52) (60) (10)
Mesentery (1) (5)
Liposarcoma 1 (20%)
Pancreas (50) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Stomach, Glandular (51) (60) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (51) (60) (10)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (51) (60) (10)
Adrenal Gland, Medulla (51) (60) (10)
Pheochromocytoma Benign 3 (6%) 4 (7%)
Islets, Pancreatic (50) (60) (10)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (51) (60) (10)
Pars Distalis, Adenoma 13 (25%) 19 (32%)
Thyroid Gland (51) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%)
Page 6
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 6 (12%) 6 (10%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (3%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (56) (10)
Adenoma 4 (8%) 3 (5%)
Carcinoma 2 (4%) 2 (4%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (51) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Uterus (53) (60) (10)
Polyp Stromal 3 (6%) 11 (18%)
Polyp Stromal, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (51) (60) (10)
Lymph Node (51) (60) (10)
Lymph Node, Mandibular (50) (59) (10)
Lymph Node, Mesenteric (51) (60) (10)
Spleen (51) (60) (10)
Thymus (46) (58) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (60) (10)
Adenocarcinoma 1 (2%) 2 (3%)
Fibroadenoma 15 (30%) 18 (30%)
Fibroadenoma, Multiple 2 (4%) 3 (5%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Skin (50) (60) (10)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Page 7
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (51) (60) (10)
Astrocytoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (51) (59) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Mediastinum, Fibrous Histiocytoma,
Metastatic, Skin 1 (2%)
Trachea (51) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (8) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%) 1 (2%)
Urinary Bladder (51) (60) (10)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(8) *(60) *(10)
Leukemia Mononuclear 11 (18%) 17 (28%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 50
Total Primary Neoplasms 68 98
Total Animals with Benign Neoplasms 34 44
Total Benign Neoplasms 49 73
Total Animals with Malignant Neoplasms 17 22
Total Malignant Neoplasms 19 25
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 11 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 9
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 10 60 10 10
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 16 13
Natural Death 5 11
Dosing Accident 6 2
Survivors
Terminal Sacrifice 23 24
Animals Examined Microscopically 60 10 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (10) (50)
Leiomyosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Polyp Adenomatous 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Intestine Small, Jejunum (59) (10) (48)
Leiomyosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Liver (60) (10) (51)
Hepatocellular Adenoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (14) (14)
Hemangioma 1 (7%)
Leiomyosarcoma, Metastatic, Uncertain
Primary Site 1 (7%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (7%)
Pancreas (59) (10) (47)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Acinus, Adenoma 1 (2%)
Acinus, Adenoma, Multiple 1 (2%)
Stomach, Forestomach (59) (10) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (59) (10) (49)
Tooth (1)
Mixed Tumor NOS 1 (100%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (10) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50)
Adrenal Gland, Medulla (60) (10) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 12 (20%) 7 (14%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (59) (10) (47)
Adenoma 1 (2%)
Carcinoma 2 (3%)
Parathyroid Gland (56) (9) (47)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (58) (10) (51)
Pars Distalis, Adenoma 18 (31%) 12 (24%)
Pars Distalis, Carcinoma 2 (3%)
Thyroid Gland (58) (10) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (14%) 10 (20%)
C-Cell, Carcinoma 3 (5%)
Follicular Cell, Adenoma 2 (3%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (10) (49)
Preputial Gland (59) (10) (50)
Adenoma 7 (12%) 4 (8%)
Carcinoma 2 (3%) 3 (6%)
Seminal Vesicle (60) (10) (50)
Testes (60) (10) (49)
Sertoli Cell Tumor Benign 1 (2%)
Bilateral, Interstitial Cell, Adenoma 35 (58%) 33 (67%)
Interstitial Cell, Adenoma 10 (17%) 9 (18%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50)
Lymph Node (60) (10) (50)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Mediastinal, Carcinoma Adenosquamous,
Metastatic, Lung 1 (2%)
Mediastinal, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Lymph Node, Mandibular (59) (10) (50)
Lymph Node, Mesenteric (59) (10) (48)
Spleen (60) (10) (49)
Fibrosarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Thymus (54) (10) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (5) (44)
Fibroadenoma 2 (5%) 2 (5%)
Skin (59) (10) (51)
Basosquamous Tumor Malignant 1 (2%) 1 (2%)
Keratoacanthoma 6 (10%) 4 (8%)
Squamous Cell Papilloma 5 (10%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3) (3)
Chordoma 1 (33%)
Fibrosarcoma 1 (33%)
Leiomyosarcoma, Metastatic, Uncertain
Primary Site 1 (33%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (33%)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10) (50)
Astrocytoma Benign 1 (2%)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
Peripheral Nerve (2) (1)
Schwannoma Benign 1 (100%)
Spinal Cord (3)
Chordoma 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (3%)
Carcinoma Adenosquamous 1 (2%)
Chordoma, Metastatic, Spinal Cord 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Nose (60) (10) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Squamous Cell Papilloma 1 (100%)
Zymbal's Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (59) (10)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (60) (10) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10) *(60) *(10)
Leukemia Mononuclear 10 (17%) 9 (15%)
Mesothelioma Benign 4 (7%) 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 54 52
Total Primary Neoplasms 144 121
Total Animals with Benign Neoplasms 53 52
Total Benign Neoplasms 114 100
Total Animals with Malignant Neoplasms 24 18
Total Malignant Neoplasms 30 20
Total Animals with Metastatic Neoplasms 6 2
Total Metastatic Neoplasm 6 12
Total Animals with Malignant Neoplasms 1 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 10 60 10 10
Scheduled Sacrifice 10 10 10 9 9 7
Early Deaths
Natural Death 6 8 2
Moribund Sacrifice 14 14
Dosing Accident 5 5 1 1
Survivors
Terminal Sacrifice 25 24
Animals Examined Microscopically 60 10 60 9
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (60) (9)
Carcinoma 1 (2%)
Intestine Large, Cecum (49) (57) (9)
Intestine Large, Colon (49) (59) (9)
Intestine Large, Rectum (49) (58) (9)
Intestine Small, Duodenum (49) (59) (9)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Intestine Small, Jejunum (48) (59) (9)
Adenocarcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Liver (51) (60) (9)
Hepatocellular Adenoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (7) (8) (1)
Carcinoma, Metastatic, Uncertain Primary Site 1 (14%)
Pancreas (48) (58) (9)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Acinus, Adenoma 2 (4%)
Acinus, Adenoma, Multiple 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (49) (58) (9)
Stomach, Forestomach (49) (60) (9)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (59) (9)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
Page 15
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (60) (9)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (60) (9)
Adenoma 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Adrenal Gland, Medulla (49) (59) (9)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 6 (12%) 9 (15%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Bilateral, Pheochromocytoma Benign 3 (6%) 4 (7%)
Islets, Pancreatic (48) (59) (9)
Carcinoma 2 (4%) 2 (3%)
Pituitary Gland (49) (60) (9)
Pars Distalis, Adenoma 18 (37%) 13 (22%)
Thyroid Gland (47) (59) (9)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 5 (11%) 4 (7%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (60) (9)
Adenoma 2 (4%) 2 (3%)
Carcinoma 3 (6%)
Prostate (50) (60) (9)
Seminal Vesicle (50) (60) (9)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Testes (51) (60) (9)
Bilateral, Interstitial Cell, Adenoma 29 (57%) 32 (53%)
Interstitial Cell, Adenoma 10 (20%) 14 (23%)
____________________________________________________________________________________________________________________________________
Page 16
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (60) (9)
Lymph Node (50) (59) (9)
Mediastinal, Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Lymph Node, Mandibular (48) (58) (9)
Lymph Node, Mesenteric (50) (57) (5)
Spleen (50) (59) (9)
Thymus (48) (55) (9)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (48) (6)
Fibroadenoma 2 (5%) 1 (2%)
Skin (50) (60) (9)
Basal Cell Adenoma 1 (2%)
Basal Cell Adenoma, Multiple 1 (2%)
Keratoacanthoma 2 (4%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (3%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (60) (9)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (60) (9)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma, Multiple,
Page 17
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Metastatic, Uncertain Primary Site 1 (2%)
Mediastinum, Carcinoma, Metastatic, Thyroid
Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Pinna, Squamous Cell Papilloma 1 (50%)
Zymbal's Gland (1) (2)
Adenoma 1 (50%)
Carcinoma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (59) (9)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (59) (9)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10) *(60) *(9)
Leukemia Mononuclear 10 (17%) 10 (17%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 18
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 49
Total Primary Neoplasms 115 107
Total Animals with Benign Neoplasms 44 49
Total Benign Neoplasms 86 90
Total Animals with Malignant Neoplasms 22 15
Total Malignant Neoplasms 29 17
Total Animals with Metastatic Neoplasms 4 1
Total Metastatic Neoplasm 13 1
Total Animals with Malignant Neoplasms 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 19
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