National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3602

TDMS Study 05086-01 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                  O-BENZYL-P-CHLOROPHENOL                                DATE: 10/22/97       
EXPERIMENT: 05086 TEST: 01                                                                                     TIME: 12:01:43       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-45042                              ROUTE: GAVAGE                                                  NTP C#: 61201C       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 120-32-1        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0MG/KG     M                                                                  
                                       INCLUDE 004    30MG/KG    M                                                                  
                                       INCLUDE 007    60MG/KG    M                                                                  
                                       INCLUDE 010    120MG/KG   M                                                                  
                                       INCLUDE 013    0MG/KG     F                                                                  
                                       INCLUDE 016    60MG/KG    F                                                                  
                                       INCLUDE 019    120MG/KG   F                                                                  
                                       INCLUDE 022    240MG/KG   F                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                                  O-BENZYL-P-CHLOROPHENOL                                DATE: 10/22/97      
EXPERIMENT: 05086 TEST: 01                                                                                     TIME: 12:01:43      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-45042                              ROUTE: GAVAGE                                                  NTP C#: 61201C      
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 120-32-1       
                              O-BENZYL-P-CHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0MG/KG     M                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 16   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      457   500   521   533   543   610   624   624   655   660                 |
 |      670   683   687   687   695   696   711   722   723   724                 |
 |      726                                                                       |
 |  CENSORED DEATHS                                                               |
 |      25    37    197   456   456   456   456   456   457   457                 |
 |      457   457   457   465   467   638                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30MG/KG    M                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 24     CENSORED DEATHS 12   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      439   456   493   509   525   525   529   543   547   562                 |
 |      603   622   631   656   659   660   669   684   711   713                 |
 |      719   722   723   725                                                     |
 |  CENSORED DEATHS                                                               |
 |      32    158   456   456   456   456   456   457   457   457                 |
 |      457   457                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 60MG/KG    M                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 15   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      319   463   515   521   554   562   565   579   633   654                 |
 |      661   661   666   668   676   694   697   701   723   726                 |
 |  CENSORED DEATHS                                                               |
 |      61    197   274   306   456   456   456   456   456   457                 |
 |      457   457   457   457   492                                               |
 |                                                                                |
 ==================================================================================
                              O-BENZYL-P-CHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 120MG/KG   M                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 14   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      13    150   327   431   459   508   527   541   543   568                 |
 |      591   641   648   687   687   694   695   716   717   719                 |
 |      719   720                                                                 |
 |  CENSORED DEATHS                                                               |
 |      80    122   324   456   456   456   456   456   457   457                 |
 |      457   457   459   464                                                     |
 |                                                                                |
 ==================================================================================
                              O-BENZYL-P-CHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0MG/KG     |   100.0 100.0 100.0 100.0 100.0  98.1  89.2  89.2  77.9  52.7      |
 |M          |                                                                    |
 |           |                                                                    |
 |30MG/KG    |   100.0 100.0 100.0 100.0 100.0  96.6  84.0  77.7  67.2  50.4      |
 |M          |                                                                    |
 |           |                                                                    |
 |60MG/KG    |   100.0 100.0 100.0  98.2  98.2  96.0  91.6  82.6  73.7  55.8      |
 |M          |                                                                    |
 |           |                                                                    |
 |120MG/KG   |    98.3  96.6  96.6  94.9  94.9  91.0  82.1  77.7  73.2  53.3      |
 |M          |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0MG/KG       30MG/KG      60MG/KG      120MG/KG |
 |                                M            M            M            M        |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.7%        50.4%        55.8%        53.3%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.959      P=0.741      P=1.000N     P=0.905  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       640.5        609.4        611.9        559.1    |
 |NATURAL DEATHS (C)      |       (18.0)       (18.9)       (22.9)       (40.6)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       610.2        614.6        606.0        589.2    |
 |(STANDARD ERROR)        |       (21.3)       (19.2)       (20.4)       (23.7)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                              O-BENZYL-P-CHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0MG/KG     F                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 12   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      416   435   465   470   500   521   568   577   583   598                 |
 |      603   628   659   676   680   680   680   682   701   717                 |
 |      717   726                                                                 |
 |  CENSORED DEATHS                                                               |
 |      23    317   456   456   456   456   456   457   457   457                 |
 |      457   457                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 60MG/KG    F                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 19     CENSORED DEATHS 11   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      15    544   610   625   629   632   632   633   646   648                 |
 |      649   660   663   674   676   676   692   716   724                       |
 |  CENSORED DEATHS                                                               |
 |      76    456   456   456   456   456   457   457   457   457                 |
 |      457                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 120MG/KG   F                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      309   345   402   471   508   562   568   579   582   583                 |
 |      598   622   640   645   649   662   665   666   670   670                 |
 |      676   680                                                                 |
 |  CENSORED DEATHS                                                               |
 |      19    456   456   456   456   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================
                              O-BENZYL-P-CHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 240MG/KG   F                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 11   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      493   541   554   600   619   622   624   632   648   649                 |
 |      652   659   661   676   680   680   684   687   693   705                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   457   457   457   457   457                 |
 |      471                                                                       |
 |                                                                                |
 ==================================================================================
                              O-BENZYL-P-CHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0MG/KG     |   100.0 100.0 100.0 100.0  98.3  92.4  88.2  77.7  73.5  54.6      |
 |F          |                                                                    |
 |           |                                                                    |
 |60MG/KG    |    98.3  98.3  98.3  98.3  98.3  98.3  96.3  96.3  73.8  61.5      |
 |F          |                                                                    |
 |           |                                                                    |
 |120MG/KG   |   100.0 100.0 100.0  96.6  94.9  92.9  90.9  78.8  66.6  56.5      |
 |F          |                                                                    |
 |           |                                                                    |
 |240MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  95.9  91.8  73.5  57.1      |
 |F          |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0MG/KG       60MG/KG      120MG/KG     240MG/KG |
 |                                F            F            F            F        |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.6%        61.5%        56.5%        57.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.918N     P=0.539N     P=1.000      P=0.784N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       603.7        618.1        579.6        642.0    |
 |NATURAL DEATHS (C)      |       (21.0)       (34.7)       (23.2)       (12.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       619.0        637.6        621.5        648.9    |
 |(STANDARD ERROR)        |       (18.7)       (19.3)       (18.6)       (13.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                      O-BENZYL-P-CHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0MG/KG     M     = 1
                                                        30MG/KG    M     = 2
                                                        60MG/KG    M     = 3
                                                        120MG/KG   M     = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1 4                                                3                 2   1
      |   4                     4                          3                 2   23
      |                                                                          1     1
      |                         4                           4                    23   21 3 1
   95 +                                                     4               4         2 2
      |                                                                                  3 1 1
      |                                                                     4    4      2  2
      |                                                                          4      4  3 11 3
   90 +
      |                                                                                 4  22 1 33       1
      |                                                                                                  1 1
      |                                                                                     2 2
P  85 +                                                                                          3 3
E     |                                                                                       22
R     |                                                                                       4   43       13  1
C     |                                                                                        2 2
E  80 +                                                                                          24   4 2   3  1 1
N     |                                                                                                        3 3
T     |                                                                                               4 2 2  4   11
      |
S  75 +                                                                                                   2 244   1 1
U     |                                                                                                     2 42 33 11
R     |
V     |                                                                                                        2 2
I  70 +
V     |                                                                                                           33 11
A     |                                                                                                          223  3
L     |
   65 +                                                                                                           2 2
      |                                                                                                               1 14
      |                                                                                                             2 332
      |                                                                                                                 1 1
   60 +                                                                                                                3  3
      |                                                                                                                 22
      |
      |                                                                                                                  22 3
   55 +
      |                                                                                                                  4  4
      |                                                                                                                   1 1
      |
   50 +                                                                                                                   2 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.
                                                      O-BENZYL-P-CHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0MG/KG     F     = 1
                                                        60MG/KG    F     = 2
                                                        120MG/KG   F     = 3
                                                        240MG/KG   F     = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1  2                                              3               1           4
      |    2                                              3    3          1  1                2
      |                                                                               4       4
      |                                                        3        3    1    1           2 4        2
   95 +                                                                 3         11
      |                                                                                         4      4 2 2
      |                                                                            1   13
      |                                                                                 3        3     4  4
   90 +                                                                                1   1               22
      |                                                                                    1     31
P     |                                                                                                   44
E     |                                                                                           11       44
R  85 +                                                                                            33
C     |                                                                                            11       2 2
E     |
N     |                                                                                             1  1
T  80 +                                                                                                11     44
      |                                                                                                3  3
S     |                                                                                                 1  1  24 2
U     |                                                                                                   3  3
R  75 +                                                                                                    1 33  1
V     |                                                                                                          1 1
I     |
V     |                                                                                                       3  3 11
A  70 +
L     |
      |                                                                                                            2 2
      |                                                                                                          33
   65 +                                                                                                             42   2
      |                                                                                                                  22
      |                                                                                                             1  1
      |                                                                                                              4 1 12 2
   60 +                                                                                                           33
      |                                                                                                            33  4  4
      |                                                                                                                   4 4
      |                                                                                                             3    11 3
   55 +                                                                                                                   1 1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 22 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.