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TDMS Study 05087-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            TRIAMTERENE


NTP Experiment-Test: 05087-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 13:32:16




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8            5            1           10                                     
    Natural Death                                      4            2            6            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           41           42           43                                     
    Moribund Sacrifice                                              1                                                               
    Natural Death                                      1            1            1                                                  
  Animals Examined Microscopically                    70           62           60           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (67)         (47)         (58)         (65)                                   
   Intestine Large, Cecum                             (67)         (50)         (59)         (70)                                   
   Intestine Small, Ileum                             (67)         (49)         (59)         (67)                                   
   Intestine Small, Jejunum                           (67)         (48)         (58)         (69)                                   
      Adenocarcinoma                                   1 (1%)                                                                       
   Liver                                              (70)         (52)         (60)         (70)                                   
      Hemangiosarcoma                                  1 (1%)                    1 (2%)                                             
      Hepatocellular Carcinoma                         3 (4%)       3 (6%)       3 (5%)       6 (9%)                                
      Hepatocellular Carcinoma, Multiple               1 (1%)       1 (2%)                    2 (3%)                                
      Hepatocellular Adenoma                           8 (11%)     12 (23%)     14 (23%)     22 (31%)                               
      Hepatocellular Adenoma, Multiple                 4 (6%)      12 (23%)     11 (18%)     14 (20%)                               
      Hepatocholangiocarcinoma                         1 (1%)                                                                       
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Serosa, Adenocarcinoma, Metastatic, Ovary                     1 (2%)                                                          
   Mesentery                                          (8)          (10)         (8)          (5)                                    
      Adenocarcinoma, Metastatic, Ovary                             1 (10%)                                                         
      Hemangiosarcoma                                  1 (13%)                                                                      
      Hepatocholangiocarcinoma, Metastatic, Uterus     1 (13%)                                                                      
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (20%)                               
   Pancreas                                           (69)         (50)         (60)         (70)                                   
      Adenocarcinoma, Metastatic, Ovary                             1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Uterus     1 (1%)                                                                       
   Salivary Glands                                    (69)         (49)         (60)         (70)                                   
   Stomach, Forestomach                               (69)         (50)         (60)         (70)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (60)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (50)         (60)         (70)                                   
      Spindle Cell, Adenoma                            3 (4%)                    3 (5%)       2 (3%)                                
   Islets, Pancreatic                                 (69)         (49)         (60)         (69)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (68)         (47)         (57)         (68)                                   
      Pars Distalis, Adenoma                           7 (10%)      5 (11%)      3 (5%)       5 (7%)                                
      Pars Intermedia, Adenoma                                                   2 (4%)       1 (1%)                                
   Thyroid Gland                                      (69)         (49)         (60)         (70)                                   
      Follicular Cell, Adenoma                         1 (1%)       1 (2%)       1 (2%)       1 (1%)                                
      Follicular Cell, Carcinoma                       1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (68)         (54)         (60)         (69)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Cystadenoma                                      1 (1%)       1 (2%)       1 (2%)       1 (1%)                                
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Uterus     1 (1%)                                                                       
      Mixed Tumor Benign                                                                      1 (1%)                                
      Teratoma                                         1 (1%)                                                                       
   Uterus                                             (68)         (54)         (60)         (70)                                   
      Adenoma                                                       2 (4%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Polyp Stromal                                                 1 (2%)       2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (60)         (70)                                   
      Hemangiosarcoma                                               1 (2%)       1 (2%)       1 (1%)                                
   Lymph Node                                         (69)         (50)         (60)         (70)                                   
      Axillary, Liposarcoma, Metastatic, Skin                       1 (2%)                                                          
      Inguinal, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                                                                    1 (1%)                                
                                                             Page   3                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Uterus                           1 (1%)                                                                       
      Renal, Hepatocholangiocarcinoma, Metastatic,                                                                                  
           Uterus                                      1 (1%)                                                                       
   Lymph Node, Mandibular                             (66)         (49)         (59)         (68)                                   
      Adenocarcinoma, Metastatic, Ovary                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (61)         (45)         (55)         (64)                                   
      Hepatocholangiocarcinoma, Metastatic, Uterus     1 (2%)                                                                       
   Spleen                                             (69)         (50)         (58)         (70)                                   
      Hemangiosarcoma                                  1 (1%)                    3 (5%)       1 (1%)                                
   Thymus                                             (58)         (44)         (53)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (43)         (53)         (61)                                   
   Skin                                               (70)         (49)         (59)         (70)                                   
      Basal Cell Carcinoma                                                                    1 (1%)                                
      Squamous Cell Carcinoma                                                                 1 (1%)                                
      Subcutaneous Tissue, Fibrosarcoma                3 (4%)                    1 (2%)       3 (4%)                                
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (1%)                                
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (60)         (70)                                   
      Vertebra, Osteosarcoma                                        1 (2%)       1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)                                                              
      Adenocarcinoma, Metastatic, Ovary                             1 (100%)                                                        
      Hepatocholangiocarcinoma, Metastatic, Uterus     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (60)         (70)                                   
      Adenocarcinoma, Metastatic, Ovary                             1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     5 (7%)       5 (10%)      2 (3%)       1 (1%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    3 (4%)                                
                                                             Page   4                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)       1 (2%)       1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Uterus     1 (1%)                                                                       
      Liposarcoma, Multiple, Metastatic, Skin                       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (3)          (2)                                    
      Adenoma                                          1 (100%)     3 (100%)     2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (61)         (60)         (70)                                   
      Capsule, Adenocarcinoma, Metastatic, Ovary                    1 (2%)                                                          
   Urinary Bladder                                    (68)         (49)         (59)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(62)        *(60)        *(70)                                   
      Lymphoma Malignant Histiocytic                   1 (1%)       3 (5%)       5 (8%)       3 (4%)                                
      Lymphoma Malignant Lymphocytic                   2 (3%)       1 (2%)                    2 (3%)                                
      Lymphoma Malignant Mixed                         9 (13%)      5 (8%)       9 (15%)      6 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          42          43          46                                       
     Total Primary Neoplasms                           56          62          70          81                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          33          30          36                                       
     Total Benign Neoplasms                            31          44          43          51                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          17          22          25                                       
     Total Malignant Neoplasms                         25          18          27          30                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           2           2                                       
     Total Metastatic Neoplasm                          9          11           4           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            3            2            8                                     
    Moribund Sacrifice                                 1            2            2            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           45           46           46                                     
  Animals Examined Microscopically                    70           64           61           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (67)         (46)         (60)         (64)                                   
   Intestine Large, Cecum                             (70)         (50)         (60)         (63)                                   
   Intestine Large, Colon                             (69)         (49)         (60)         (67)                                   
   Intestine Small, Duodenum                          (70)         (50)         (59)         (65)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Intestine Small, Ileum                             (69)         (49)         (59)         (65)                                   
   Intestine Small, Jejunum                           (70)         (50)         (59)         (65)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Liver                                              (70)         (53)         (60)         (70)                                   
      Hemangiosarcoma                                  1 (1%)       1 (2%)       3 (5%)                                             
      Hepatoblastoma                                                1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma                         4 (6%)       7 (13%)      3 (5%)      13 (19%)                               
      Hepatocellular Carcinoma, Multiple               1 (1%)                                                                       
      Hepatocellular Adenoma                          14 (20%)     14 (26%)     13 (22%)      9 (13%)                               
      Hepatocellular Adenoma, Multiple                 4 (6%)      11 (21%)      8 (13%)     11 (16%)                               
   Mesentery                                          (3)          (3)          (4)          (2)                                    
   Pancreas                                           (70)         (50)         (60)         (70)                                   
   Stomach, Forestomach                               (69)         (50)         (60)         (68)                                   
      Squamous Cell Papilloma                                                                 1 (1%)                                
   Stomach, Glandular                                 (70)         (50)         (60)         (69)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (50)         (60)         (69)                                   
      Capsule, Adenoma                                 1 (1%)                                                                       
   Adrenal Gland, Medulla                             (69)         (50)         (58)         (70)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
   Thyroid Gland                                      (70)         (50)         (60)         (70)                                   
      C-Cell, Adenoma                                                            1 (2%)                                             
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (50)         (60)         (70)                                   
   Prostate                                           (70)         (50)         (60)         (70)                                   
   Seminal Vesicle                                    (60)         (50)         (60)         (60)                                   
   Testes                                             (70)         (50)         (60)         (70)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (69)         (50)         (60)         (70)                                   
   Lymph Node                                         (70)         (50)         (60)         (70)                                   
   Lymph Node, Mandibular                             (67)         (48)         (59)         (70)                                   
   Lymph Node, Mesenteric                             (62)         (46)         (53)         (55)                                   
   Spleen                                             (70)         (50)         (60)         (70)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)       2 (3%)                                             
   Thymus                                             (56)         (40)         (46)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (69)         (50)         (59)         (70)                                   
      Subcutaneous Tissue, Fibroma                     1 (1%)                                                                       
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (69)         (50)         (60)         (69)                                   
      Femur, Hemangiosarcoma, Metastatic, Spleen                                 1 (2%)                                             
   Skeletal Muscle                                    (1)          (2)          (1)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (60)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (51)         (60)         (70)                                   
      Adenocarcinoma, Metastatic, Harderian Gland      1 (1%)                                                                       
      Alveolar/Bronchiolar Adenoma                     5 (7%)      10 (20%)      9 (15%)      9 (13%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (6%)       1 (2%)       4 (7%)       4 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (3%)       2 (4%)       2 (3%)       1 (1%)                                
   Nose                                               (70)         (50)         (60)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (6)          (2)                                    
      Adenocarcinoma                                   1 (33%)                                1 (50%)                               
      Adenoma                                                       1 (33%)      3 (50%)      1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (64)         (61)         (70)                                   
   Urinary Bladder                                    (70)         (50)         (59)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(64)        *(61)        *(70)                                   
      Lymphoma Malignant Histiocytic                                             1 (2%)       1 (1%)                                
      Lymphoma Malignant Lymphocytic                   1 (1%)                                                                       
      Lymphoma Malignant Mixed                         5 (7%)       3 (5%)       4 (7%)       4 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05087-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          42          37          38                                       
     Total Primary Neoplasms                           44          56          57          60                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          30          31          27                                       
     Total Benign Neoplasms                            25          39          37          34                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          17          16          22                                       
     Total Malignant Neoplasms                         19          17          20          26                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1                                                   
     Total Metastatic Neoplasm                          1           2           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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