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TDMS Study 05087-03 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            TRIAMTERENE


NTP Experiment-Test: 05087-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 15:25:18




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60                                                               
  Scheduled Sacrifice                                 10            9                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      3            9                                                               
    Moribund Sacrifice                                 7            4                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           38                                                               
  Animals Examined Microscopically                    60           60                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)                                                             
      Ulcer                                            1 (2%)                                                                       
      Muscularis, Degeneration                         1 (2%)                                                                       
   Gallbladder                                        (60)         (59)                                                             
      Mucosa, Hyperplasia                                           1 (2%)                                                          
   Intestine Small, Ileum                             (59)         (60)                                                             
      Peyer's Patch, Inflammation, Granulomatous                    1 (2%)                                                          
   Liver                                              (60)         (60)                                                             
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                 1 (2%)       6 (10%)                                                         
      Clear Cell Focus                                              4 (7%)                                                          
      Eosinophilic Focus                              10 (17%)     16 (27%)                                                         
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                     2 (3%)       1 (2%)                                                          
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Acute                                               1 (2%)                                                          
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Mesentery                                          (2)          (7)                                                              
      Ectopic Tissue                                   1 (50%)                                                                      
      Artery, Inflammation, Chronic Active                          1 (14%)                                                         
      Fat, Necrosis                                    1 (50%)      6 (86%)                                                         
   Pancreas                                           (59)         (59)                                                             
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Acinus, Atrophy                                  3 (5%)       1 (2%)                                                          
      Duct, Ectasia                                    2 (3%)       1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)                                                             
      Acanthosis                                       1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (60)         (60)                                                             
      Dysplasia                                                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
      Degeneration                                     2 (3%)                                                                       
      Mineralization                                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)                                                             
      Hypertrophy                                      3 (5%)       2 (3%)                                                          
   Adrenal Gland, Medulla                             (59)         (60)                                                             
      Hyperplasia                                                   1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (57)                                                             
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (59)         (56)                                                             
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      25 (42%)     18 (32%)                                                         
   Thyroid Gland                                      (60)         (60)                                                             
      Cyst                                             1 (2%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia                     9 (15%)     33 (55%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (7)          (4)                                                              
      Dilatation                                       5 (71%)      4 (100%)                                                        
      Inflammation                                     1 (14%)                                                                      
   Ovary                                              (60)         (58)                                                             
      Cyst                                            15 (25%)     16 (28%)                                                         
      Cyst, Multiple                                                1 (2%)                                                          
   Uterus                                             (60)         (60)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Cystic, Glandular                  52 (87%)     47 (78%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)                                                             
      Myelofibrosis                                   19 (32%)     19 (32%)                                                         
   Lymph Node                                         (60)         (60)                                                             
      Lumbar, Cyst                                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Inflammation, Granulomatous                      1 (2%)                                                          
   Lymph Node, Mandibular                             (60)         (60)                                                             
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
   Lymph Node, Mesenteric                             (57)         (56)                                                             
      Congestion                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Infiltration Cellular, Histiocyte                2 (4%)       1 (2%)                                                          
   Spleen                                             (59)         (60)                                                             
      Hematopoietic Cell Proliferation                 1 (2%)       5 (8%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       2 (3%)                                                          
      Lymphoid Follicle, Hyperplasia                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (57)                                                             
      Ectasia                                                       1 (2%)                                                          
      Hyperplasia                                      2 (4%)       2 (4%)                                                          
   Skin                                               (60)         (60)                                                             
      Alopecia                                         1 (2%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
      Compression                                                   1 (2%)                                                          
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Arteriole, Infiltration Cellular, Lymphocyte     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                                                          
      Pleura, Infiltration Cellular, Lymphocyte        1 (2%)                                                                       
   Nose                                               (60)         (59)                                                             
      Inflammation, Acute                              2 (3%)       3 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (4)                                                              
      Hyperplasia                                      4 (100%)     1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Nephropathy                                     20 (33%)     24 (40%)                                                         
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60                                                               
  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      4            7                                                               
    Moribund Sacrifice                                 3            4                                                               
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                42           39                                                               
  Animals Examined Microscopically                    60           60                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (57)         (60)                                                             
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (59)                                                             
      Peyer's Patch, Infiltration Cellular,                                                                                         
          Histiocyte                                                1 (2%)                                                          
   Liver                                              (59)         (60)                                                             
      Basophilic Focus                                 1 (2%)       7 (12%)                                                         
      Clear Cell Focus                                 7 (12%)      5 (8%)                                                          
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Congestion                                                    2 (3%)                                                          
      Eosinophilic Focus                              11 (19%)     10 (17%)                                                         
      Eosinophilic Focus, Multiple                     1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Infarct                                          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Regeneration                                                  1 (2%)                                                          
      Vacuolization Cytoplasmic                                     2 (3%)                                                          
      Hepatocyte, Necrosis                                          1 (2%)                                                          
   Mesentery                                          (2)          (1)                                                              
      Fat, Necrosis                                                 1 (100%)                                                        
   Pancreas                                           (58)         (60)                                                             
      Acinus, Atrophy                                  2 (3%)       4 (7%)                                                          
      Duct, Cyst                                                    1 (2%)                                                          
   Stomach, Forestomach                               (59)         (60)                                                             
      Acanthosis                                       2 (3%)       2 (3%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Stomach, Glandular                                 (59)         (60)                                                             
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mucosa, Mineralization                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (60)                                                             
      Capsule, Hyperplasia                             8 (13%)      1 (2%)                                                          
   Adrenal Gland, Cortex                              (60)         (60)                                                             
      Hypertrophy                                     19 (32%)      8 (13%)                                                         
   Islets, Pancreatic                                 (57)         (59)                                                             
      Hyperplasia                                      2 (4%)       2 (3%)                                                          
   Pituitary Gland                                    (60)         (57)                                                             
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       1 (2%)       3 (5%)                                                          
   Thyroid Gland                                      (60)         (60)                                                             
      Follicular Cell, Hyperplasia                                 16 (27%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)                                                             
      Granuloma Sperm                                               1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (3%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Preputial Gland                                    (41)         (37)                                                             
      Dilatation                                      36 (88%)     37 (100%)                                                        
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (7%)       1 (3%)                                                          
   Seminal Vesicle                                    (60)         (60)                                                             
      Inflammation, Acute                              1 (2%)                                                                       
   Testes                                             (60)         (60)                                                             
      Degeneration                                     3 (5%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)                                                             
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node, Mesenteric                             (51)         (54)                                                             
      Congestion                                       2 (4%)       2 (4%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Inflammation, Granulomatous                                   2 (4%)                                                          
   Spleen                                             (57)         (60)                                                             
      Hematopoietic Cell Proliferation                 3 (5%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)                                                             
      Subcutaneous Tissue, Abscess                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
      Compression                                      1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)                                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (3%)                                                          
   Nose                                               (60)         (60)                                                             
      Concretion                                       1 (2%)                                                                       
      Inflammation, Acute                              4 (7%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
   Eye                                                (1)          (1)                                                              
      Cornea, Inflammation, Chronic Active                          1 (100%)                                                        
   Harderian Gland                                    (5)          (6)                                                              
      Hyperplasia                                      4 (80%)                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05087-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Nephropathy                                     55 (92%)     53 (88%)                                                         
   Urinary Bladder                                    (60)         (60)                                                             
      Inflammation, Acute                              1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
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