National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3796

TDMS Study 05087-03 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            TRIAMTERENE


NTP Experiment-Test: 05087-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 15:25:20




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60                                                               
  Scheduled Sacrifice                                 10            9                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      3            9                                                               
    Moribund Sacrifice                                 7            4                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           38                                                               
  Animals Examined Microscopically                    60           60                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (59)                                                             
   Intestine Large, Cecum                             (59)         (60)                                                             
   Intestine Large, Colon                             (60)         (60)                                                             
      Fibrosarcoma, Metastatic, Uterus                              1 (2%)                                                          
   Intestine Large, Rectum                            (60)         (59)                                                             
   Intestine Small, Ileum                             (59)         (60)                                                             
   Intestine Small, Jejunum                           (59)         (60)                                                             
   Liver                                              (60)         (60)                                                             
      Hepatocellular Carcinoma                         6 (10%)      9 (15%)                                                         
      Hepatocellular Carcinoma, Multiple                            2 (3%)                                                          
      Hepatocellular Adenoma                           4 (7%)       9 (15%)                                                         
      Hepatocellular Adenoma, Multiple                 3 (5%)      19 (32%)                                                         
   Pancreas                                           (59)         (59)                                                             
   Salivary Glands                                    (60)         (60)                                                             
   Stomach, Forestomach                               (60)         (60)                                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)                                                             
      Spindle Cell, Adenoma                            2 (3%)       2 (3%)                                                          
   Adrenal Gland, Medulla                             (59)         (60)                                                             
   Islets, Pancreatic                                 (59)         (57)                                                             
      Adenoma                                          1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (59)         (56)                                                             
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Pars Distalis, Adenoma                                        2 (4%)                                                          
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (7)          (4)                                                              
      Hemangiosarcoma                                  1 (14%)                                                                      
   Ovary                                              (60)         (58)                                                             
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Teratoma Benign                                               1 (2%)                                                          
   Uterus                                             (60)         (60)                                                             
      Adenocarcinoma                                   1 (2%)                                                                       
      Fibrosarcoma                                                  1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (60)                                                             
   Lymph Node, Mandibular                             (60)         (60)                                                             
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
   Lymph Node, Mesenteric                             (57)         (56)                                                             
   Spleen                                             (59)         (60)                                                             
      Hemangiosarcoma                                  3 (5%)                                                                       
   Thymus                                             (56)         (52)                                                             
      Fibrosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)                                                             
      Subcutaneous Tissue, Mast Cell Tumor                                                                                          
          Malignant                                                 1 (2%)                                                          
      Subcutaneous Tissue, Myxosarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (59)                                                             
      Fibrosarcoma                                     2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (3%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       4 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (4)                                                              
      Adenoma                                                       3 (75%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
   Urinary Bladder                                    (60)         (59)                                                             
      Fibrosarcoma, Metastatic, Uterus                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)                                                             
      Lymphoma Malignant Histiocytic                                3 (5%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)       2 (3%)                                                          
      Lymphoma Malignant Mixed                         8 (13%)     12 (20%)                                                         
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          45                                                               
     Total Primary Neoplasms                           41          73                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 12          31                                                               
     Total Benign Neoplasms                            13          39                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          30                                                               
     Total Malignant Neoplasms                         28          34                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           5                                                               
     Total Metastatic Neoplasm                          2           6                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60                                                               
  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      4            7                                                               
    Moribund Sacrifice                                 3            4                                                               
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                42           39                                                               
  Animals Examined Microscopically                    60           60                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (58)                                                             
   Intestine Large, Cecum                             (59)         (60)                                                             
      Fibrosarcoma                                     1 (2%)                                                                       
   Intestine Large, Colon                             (58)         (60)                                                             
   Intestine Large, Rectum                            (59)         (60)                                                             
   Intestine Small, Duodenum                          (57)         (60)                                                             
   Intestine Small, Jejunum                           (59)         (59)                                                             
   Liver                                              (59)         (60)                                                             
      Hemangiosarcoma                                  2 (3%)                                                                       
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                         8 (14%)      8 (13%)                                                         
      Hepatocellular Carcinoma, Multiple               1 (2%)       3 (5%)                                                          
      Hepatocellular Adenoma                          10 (17%)     13 (22%)                                                         
      Hepatocellular Adenoma, Multiple                11 (19%)     24 (40%)                                                         
   Mesentery                                          (2)          (1)                                                              
      Adenocarcinoma                                   1 (50%)                                                                      
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (50%)                                                                      
   Pancreas                                           (58)         (60)                                                             
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (2%)                                                                       
   Salivary Glands                                    (60)         (60)                                                             
   Stomach, Forestomach                               (59)         (60)                                                             
   Stomach, Glandular                                 (59)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)                                                             
      Spindle Cell, Adenoma                                         1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (60)                                                             
   Islets, Pancreatic                                 (57)         (59)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (60)         (57)                                                             
      Pars Distalis, Adenoma                                        1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)                                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)                                                             
   Prostate                                           (60)         (60)                                                             
   Seminal Vesicle                                    (60)         (60)                                                             
   Testes                                             (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)                                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (60)         (60)                                                             
      Fibrosarcoma, Metastatic, Lymph Node             1 (2%)                                                                       
   Lymph Node, Mandibular                             (60)         (60)                                                             
   Lymph Node, Mesenteric                             (51)         (54)                                                             
   Spleen                                             (57)         (60)                                                             
      Hemangiosarcoma                                  2 (4%)                                                                       
   Thymus                                             (49)         (52)                                                             
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)                                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)                                                             
      Maxilla, Fibrosarcoma                            1 (2%)                                                                       
      Vertebra, Coccygeal, Osteosarcoma                1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (2)                                                              
      Hindlimb, Fibrosarcoma                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)                                                             
      Alveolar/Bronchiolar Adenoma                     6 (10%)      9 (15%)                                                         
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   7 (12%)      5 (8%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic                                                1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       3 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Fibrosarcoma                                     1 (100%)                                                                     
   Harderian Gland                                    (5)          (6)                                                              
      Adenoma                                          1 (20%)      6 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Carcinoma                                        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Artery, Hepatocellular Carcinoma, Metastatic                  1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)                                                             
      Papilloma                                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)                                                             
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                         5 (8%)       8 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05087-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 15:25:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         400 PPM                                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          45                                                               
     Total Primary Neoplasms                           64          85                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          40                                                               
     Total Benign Neoplasms                            30          57                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          26                                                               
     Total Malignant Neoplasms                         34          28                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           4                                                               
     Total Metastatic Neoplasm                         10           6                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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