National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3802

TDMS Study 05087-03 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/11/94   
EXP: 05087                       TRIAMTERENE                   TIME: 15:33:45   
TEST: 03              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 56042B   
CONT: N01-ES-45041                                             CAS: 396-01-0    
PATHOLOGIST: L. MEZZA                        S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/11/94  
EXP: 05087                       TRIAMTERENE                   TIME: 15:33:45  
TEST: 03              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 56042B  
CONT: N01-ES-45041                                             CAS: 396-01-0   
PATHOLOGIST: L. MEZZA                        S. EUSTIS                         

                                    TRIAMTERENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0PPM                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 7      CENSORED DEATHS 10   TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      440   534   622   701   709   712   717                                   |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   463   463   463   463   463                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 400 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      494   522   554   593   633   666   671   694   701   718                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   463   463   463   463   463                 |
 |                                                                                |
 ==================================================================================

                                    TRIAMTERENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0PPM       |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  96.3  94.3  86.3      |
 |           |                                                                    |
 |           |                                                                    |
 |400 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  92.0  90.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0PPM                      400 PPM               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       86.3%                     78.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.415                   P=0.415               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       633.6                     633.6                 |
 |NATURAL DEATHS (C)      |       (41.1)                    (24.5)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       673.5                     667.2                 |
 |(STANDARD ERROR)        |       (13.6)                    (13.5)                |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    TRIAMTERENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0PPM                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 10     CENSORED DEATHS 10   TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      488   534   539   555   616   642   683   701   712   724                 |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   463   463   463   463   463                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 400 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 9    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      412   534   534   578   605   639   663   673   676   682                 |
 |      687   687   695                                                           |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   463   463   463   463                       |
 |                                                                                |
 ==================================================================================

                                    TRIAMTERENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0PPM       |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  92.0  88.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |400 PPM    |   100.0 100.0 100.0 100.0  98.3  98.3  94.4  90.5  86.5  74.7      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0PPM                      400 PPM               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       80.0%                     74.7%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.643                   P=0.643               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       619.4                     620.4                 |
 |NATURAL DEATHS (C)      |       (27.1)                    (23.6)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       667.1                     666.2                 |
 |(STANDARD ERROR)        |       (13.7)                    (13.4)                |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            TRIAMTERENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0PPM             = 1
                                                        400 PPM          = 2

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 + 1                                                                    1        2
      |
      |
      |                                                                      1               1
   98 +                                                                               2    2
      |
      |
      |                                                                                      1            1
   96 +                                                                                    2    2
      |
      |
      |                                                                                                   1            1
   94 +                                                                                         2     2
      |
P     |
E     |                                                                                                                11
R  92 +                                                                                               2     2
C     |
E     |
N     |
T  90 +                                                                                                     2     2
      |
S     |
U     |                                                                                                                 11
R  88 +
V     |
I     |
V     |                                                                                                                  1  1
A  86 +                                                                                                           2   2
L     |
      |
      |
   84 +                                                                                                               22
      |
      |
      |
   82 +                                                                                                                2 2
      |
      |
      |
   80 +                                                                                                                  22
      |
      |
      |
   78 +                                                                                                                   2 2
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 1 obs hidden.

                                                            TRIAMTERENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0PPM             = 1
                                                        400 PPM          = 2

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

        |
        |
  100.0 +1                                                                2           1
        |
        |
        |                                                                 2           1       1
   97.5 +
        |
        |
        |
   95.0 +
        |                                                                                     2     2
        |                                                                                     1  1
        |
P  92.5 +                                                                                           2    2
E       |                                                                                        1        1
R       |
C       |                                                                                                2    2
E  90.0 +                                                                                                 1   1
N       |
T       |                                                                                                     2   2
        |                                                                                                     1      1
S  87.5 +
U       |
R       |                                                                                                         2 21  1
V       |
I  85.0 +
V       |
A       |                                                                                                               11
L       |
   82.5 +                                                                                                           22
        |                                                                                                                1 1
        |
        |                                                                                                            22
   80.0 +                                                                                                                  1 1
        |
        |
        |
   77.5 +
        |                                                                                                             22
        |
        |
   75.0 +                                                                                                              2     2
        |
        -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
         0         10         20         30         40         50         60         70         80         90         100        110

                                                                    WEEK

NOTE: 2 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.