National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3808

TDMS Study 05087-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            TRIAMTERENE


NTP Experiment-Test: 05087-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 11:14:46




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           11           12           18                                     
    Natural Death                                      4            5            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           34           34           29                                     
  Animals Examined Microscopically                    70           61           63           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (70)         (61)         (61)         (70)                                   
      Hepatocellular Adenoma                                                                  1 (1%)                                
      Hepatocellular Adenoma, Multiple                                                        1 (1%)                                
   Mesentery                                          (4)          (2)          (4)          (1)                                    
   Pancreas                                           (70)         (50)         (50)         (70)                                   
   Stomach, Forestomach                               (70)         (50)         (50)         (70)                                   
   Stomach, Glandular                                 (70)         (50)         (50)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (50)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (50)         (50)         (70)                                   
      Adenoma                                          2 (3%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (70)         (50)         (50)         (70)                                   
      Pheochromocytoma Malignant                       1 (1%)       1 (2%)                                                          
      Pheochromocytoma Benign                                       1 (2%)                    1 (1%)                                
   Islets, Pancreatic                                 (70)         (50)         (50)         (70)                                   
      Adenoma                                          3 (4%)                    2 (4%)       1 (1%)                                
   Pituitary Gland                                    (70)         (53)         (52)         (69)                                   
      Pars Distalis, Adenoma                          22 (31%)     21 (40%)     25 (48%)     28 (41%)                               
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (70)         (50)         (50)         (70)                                   
      C-Cell, Adenoma                                  5 (7%)      11 (22%)      5 (10%)     10 (14%)                               
      C-Cell, Adenoma, Multiple                                                  1 (2%)                                             
      C-Cell, Carcinoma                                                          1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicle, Adenocarcinoma                                                   1 (2%)                                             
      Follicle, Adenoma                                                          1 (2%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Chemodectoma Malignant                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (62)         (49)         (50)         (67)                                   
      Adenoma                                          3 (5%)       3 (6%)       4 (8%)       2 (3%)                                
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Adenoma                                                                      1 (1%)                                
   Ovary                                              (70)         (50)         (50)         (70)                                   
      Granulosa Cell Tumor Malignant                   1 (1%)                                                                       
      Granulosa Cell Tumor Benign                                                             1 (1%)                                
   Uterus                                             (70)         (51)         (50)         (70)                                   
      Leiomyoma                                                                               2 (3%)                                
      Polyp Stromal                                    5 (7%)       7 (14%)      5 (10%)      5 (7%)                                
      Cervix, Squamous Cell Carcinoma                  1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (50)         (70)                                   
   Lymph Node                                         (70)         (51)         (50)         (70)                                   
   Lymph Node, Mandibular                             (68)         (51)         (49)         (70)                                   
   Lymph Node, Mesenteric                             (68)         (48)         (50)         (68)                                   
   Spleen                                             (70)         (50)         (50)         (70)                                   
   Thymus                                             (64)         (46)         (46)         (65)                                   
      Mediastinum, Schwannoma Malignant                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (67)         (49)         (49)         (66)                                   
      Adenoma                                          4 (6%)                    4 (8%)       1 (2%)                                
      Fibroadenoma                                    16 (24%)     11 (22%)     14 (29%)     12 (18%)                               
      Fibroadenoma, Multiple                           4 (6%)       5 (10%)      2 (4%)       1 (2%)                                
   Skin                                               (70)         (50)         (50)         (70)                                   
      Keratoacanthoma                                                                         1 (1%)                                
      Subcutaneous Tissue, Fibroma                                  2 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                                                                       
      Subcutaneous Tissue, Neurofibrosarcoma                                                  1 (1%)                                
                                                             Page   3                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (50)         (70)                                   
   Peripheral Nerve                                   (1)                       (1)                                                 
      Sciatic, Schwannoma Malignant                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (50)         (70)                                   
      Adenocarcinoma, Metastatic, Thyroid Gland                                  1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     1 (1%)       2 (4%)                    1 (1%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (1%)                                                                       
      Mediastinum, Schwannoma Malignant                1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)          (1)                                    
      Pinna, Fibroma                                                             1 (100%)                                           
      Pinna, Schwannoma Malignant                                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (60)         (60)         (70)                                   
   Urinary Bladder                                    (69)         (49)         (50)         (70)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(61)        *(63)        *(70)                                   
      Leukemia Mononuclear                             8 (11%)     11 (18%)      7 (11%)      9 (13%)                               
      Mesothelioma Malignant                           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          45          42          42                                       
     Total Primary Neoplasms                           84          77          74          81                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          39          40          37                                       
     Total Benign Neoplasms                            65          64          65          70                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          13           9          10                                       
     Total Malignant Neoplasms                         19          13           9          11                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       2                                                   
     Total Metastatic Neoplasm                          1                       2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           20           18           17                                     
    Natural Death                                      4            5           13            6                                     
    Drowned                                            3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           25           19           27                                     
  Animals Examined Microscopically                    70           60           61           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (69)         (48)         (49)         (67)                                   
      Adenocarcinoma                                                                          1 (1%)                                
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Jejunum                           (68)         (50)         (49)         (67)                                   
      Adenoma                                                       1 (2%)                                                          
   Liver                                              (70)         (56)         (55)         (69)                                   
      Cholangioma                                                                             1 (1%)                                
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Hepatocellular Adenoma                                        4 (7%)       4 (7%)       2 (3%)                                
      Hepatocellular Adenoma, Multiple                              2 (4%)                    1 (1%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Mesentery                                          (4)          (4)          (4)          (10)                                   
      Lipoma                                                                     1 (25%)                                            
   Pancreas                                           (70)         (51)         (50)         (68)                                   
   Stomach, Forestomach                               (70)         (51)         (51)         (69)                                   
      Squamous Cell Papilloma                                       1 (2%)                    1 (1%)                                
   Stomach, Glandular                                 (70)         (51)         (50)         (68)                                   
   Tongue                                             (1)                       (1)          (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Tooth                                                           (1)          (1)          (1)                                    
      Gingiva, Squamous Cell Carcinoma                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (60)         (60)         (70)                                   
      Chemodectoma Benign                                                        1 (2%)                                             
      Hemangiosarcoma                                                                         1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (51)         (50)         (70)                                   
      Adenoma                                          1 (1%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (70)         (51)         (50)         (69)                                   
      Pheochromocytoma Malignant                       1 (1%)       2 (4%)                                                          
      Pheochromocytoma Benign                          8 (11%)     10 (20%)      7 (14%)      5 (7%)                                
      Bilateral, Pheochromocytoma Benign               2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
   Islets, Pancreatic                                 (70)         (51)         (50)         (69)                                   
      Adenoma                                          2 (3%)       1 (2%)       5 (10%)      1 (1%)                                
   Parathyroid Gland                                  (64)         (47)         (50)         (68)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (70)         (52)         (49)         (69)                                   
      Pars Distalis, Adenoma                           8 (11%)      7 (13%)      7 (14%)      9 (13%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (70)         (50)         (50)         (69)                                   
      Bilateral, C-Cell, Adenoma                       1 (1%)       1 (2%)       1 (2%)       1 (1%)                                
      C-Cell, Adenoma                                 10 (14%)      6 (12%)     11 (22%)      9 (13%)                               
      Follicle, Adenoma                                1 (1%)       1 (2%)       2 (4%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Chemodectoma Benign                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (51)         (50)         (69)                                   
   Preputial Gland                                    (70)         (51)         (51)         (67)                                   
      Adenoma                                          3 (4%)       2 (4%)       5 (10%)      3 (4%)                                
   Prostate                                           (68)         (49)         (50)         (69)                                   
   Seminal Vesicle                                    (69)         (48)         (50)         (69)                                   
   Testes                                             (70)         (51)         (56)         (69)                                   
      Bilateral, Interstitial Cell, Adenoma           43 (61%)     43 (84%)     48 (86%)     49 (71%)                               
      Interstitial Cell, Adenoma                       9 (13%)      5 (10%)      7 (13%)      8 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (51)         (50)         (70)                                   
   Lymph Node                                         (70)         (51)         (50)         (70)                                   
      Pancreatic, Pheochromocytoma Malignant,                                                                                       
          Metastatic, Adrenal Gland                    1 (1%)                                                                       
   Lymph Node, Mandibular                             (70)         (50)         (50)         (70)                                   
   Lymph Node, Mesenteric                             (68)         (48)         (47)         (67)                                   
                                                             Page   7                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (70)         (51)         (50)         (70)                                   
      Leiomyosarcoma                                   2 (3%)                                                                       
   Thymus                                             (62)         (47)         (46)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Lung                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (38)         (35)         (57)                                   
      Fibroadenoma                                                                            1 (2%)                                
   Skin                                               (69)         (51)         (50)         (68)                                   
      Basal Cell Adenoma                                            1 (2%)       1 (2%)                                             
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Basosquamous Tumor Malignant                     2 (3%)                                                                       
      Basosquamous Tumor Benign                                                  1 (2%)       1 (1%)                                
      Keratoacanthoma                                  2 (3%)       2 (4%)       1 (2%)       1 (1%)                                
      Squamous Cell Papilloma                          1 (1%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (1%)       2 (4%)       3 (6%)       2 (3%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (51)         (50)         (70)                                   
      Osteosarcoma                                                  1 (2%)       1 (2%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (50)         (70)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Granular Cell Tumor Benign                       1 (1%)                                                                       
      Oligodendroglioma Benign                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (51)         (50)         (70)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                             1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Nose                                               (70)         (51)         (50)         (70)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                    (1)                                    
      Middle Ear, Squamous Cell Papilloma              1 (50%)                                                                      
      Pinna, Fibrosarcoma                                                                     1 (100%)                              
      Pinna, Squamous Cell Papilloma                   1 (50%)                                                                      
   Zymbal's Gland                                                  (1)          (2)                                                 
      Adenoma                                                       1 (100%)                                                        
      Carcinoma                                                                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (51)         (52)         (70)                                   
      Adenoma                                          1 (1%)                    1 (2%)                                             
      Liposarcoma                                                   1 (2%)                                                          
   Urinary Bladder                                    (69)         (48)         (50)         (67)                                   
      Adenoma                                                                                 1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(60)        *(61)        *(70)                                   
      Leukemia Mononuclear                            22 (31%)     23 (38%)     19 (31%)     18 (26%)                               
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Mixed                         1 (1%)                                                                       
      Mesothelioma Malignant                                        2 (3%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05087-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            55          52          58          60                                       
     Total Primary Neoplasms                          128         127         136         125                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 54          50          58          58                                       
     Total Benign Neoplasms                           100          95         111         100                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          29          24          23                                       
     Total Malignant Neoplasms                         28          32          25          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           3                                                   
     Total Metastatic Neoplasm                          1           3           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.