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TDMS Study 05087-01 Pathology Tables

NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97
Route: DOSED FEED                                                                                                 Time: 15:56:08




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|             
                                           | 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                   X  X  X  X  X  X  X  X  X  X     X           X        X|             
      Clear Cell Focus                     |                                        X                                 |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                4         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                      1  1  1              1  1  1  1  1              1   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                   3      |             
      Periportal, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                    +  +   |             
      Inflammation, Chronic                |                                                                      2   |             
      Fat, Necrosis                        |                                              1                    2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               1                                          |             
      Acinus, Atrophy                      |    2           1           1        1           1     1        3         |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        2                                 |             
      Hyperkeratosis                       |                                        2                                 |             
      Ulcer                                |    4        2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
      Ulcer                                |             1  1                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|             
                                           | 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endothelium, Hyperplasia             |                                                                          |             
      Myocardium, Degeneration             |    2              1  1  2  1     1     2     1                          3|             
      Myocardium, Degeneration, Multifocal |                                           1                              |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hyperplasia                          |                2  2     2                    1                           |             
      Hyperplasia, Nodular                 |                                                    1                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hyperplasia                          |                2                 3                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                            2           3     3                           |             
      Pars Intermedia, Hyperplasia         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2        2  1  2     2  2  3  2  1  2  1  2     1  1  2     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic                |             1  1  1        1                 1                 2     1  1|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Granulomatous          |                                                                2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Epithelium, Hyperplasia      |             2  3                                                         |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|             
                                           | 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Atrophy                     |                                                                          |             
      Femoral, Hyperplasia, Re Cell        | 1     2  2                                      1           1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Sinus, Ectasia             |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                3  2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       3  1                                      2           3            |             
      Sinus, Ectasia                       |                                                          2              2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2                                3               |             
      Hyperplasia, Lymphoid                |                                                                1         |             
      Infarct                              |    3        2                                                            |             
      Inflammation, Granulomatous          |                            2                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Cystic                  |    2        3                                2           2              2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |    3        2  3                                                         |             
      Hypothalamus, Compression            |                               3                                         4|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitium, Inflammation, Chronic  |                                                                         1|             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic, Multifocal              |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|             
                                           | 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +                                                  +            |             
      Inflammation, Chronic, Multifocal    |       1  1                                                  1            |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1        1  1        1     2        2     1           1     1  1     1|             
      Nephropathy, Multifocal              |                                     1              1  1                  |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|             
                                           | 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |    X  X  X  X     X  X     X     X  X  X        X     X  X  X  X  X  X  X|             
      Clear Cell Focus                     |       X              X                                                   |             
      Fatty Change                         |                         4                                                |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Granulomatous          |       1  1                          1           1           1  1     1   |             
      Mixed Cell Focus                     |                      X                                                   |             
      Necrosis, Coagulative                |                                                                          |             
      Periportal, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |       1           2                    1                    2           1|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                         2|             
      Hyperkeratosis                       |                                                                         2|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                         1                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                   +                                                      |             
      Acanthosis                           |                   2                                                      |             
      Hyperkeratosis                       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|             
                                           | 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
      Aorta, Inflammation, Chronic         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endothelium, Hyperplasia             |                                                                          |             
      Myocardium, Degeneration             |    1  2  1  2                 1     1           2     1     1        2  1|             
      Myocardium, Degeneration, Multifocal |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                      1                             3  1                  |             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                   X     X                                X               |             
      Pars Distalis, Hyperplasia           | 2  2  2                       3                             1            |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  2     2     1     1  2  1  1  2  2        2  1  3  1  2  3  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Inflammation, Chronic                |                   1     2           1           2                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Epithelium, Hyperplasia      |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|             
                                           | 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Atrophy                     |                                                                          |             
      Femoral, Hyperplasia, Re Cell        |                2                          1                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Sinus, Ectasia             |                            3                                             |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                3                          3                              |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Cystic                  | 2  1     2              1     1                       2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |    3                                                                     |             
      Femur, Osteopetrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |             4                                      3  4        3         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitium, Inflammation, Chronic  |                         2                                                |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|             
                                           | 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0 PPM                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens, Cataract                       |                                                                      3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                          +                              |             
      Inflammation, Chronic, Multifocal    |                                           1                              |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1  1  1  1        2     1  2        1        1  1        1  2     2  2|             
      Nephropathy, Multifocal              |                                                                   1      |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3|              |            |
                                           | 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parasite Metazoan                    | X                                                                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Angiectasis, Focal                   |                                           1                              |      1  1.0|
      Basophilic Focus                     | X  X     X  X  X           X        X  X  X  X        X                  |     42     |
      Clear Cell Focus                     |                                                                          |      3     |
      Fatty Change                         |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Granulomatous          | 1     1  1     1                 2        1  1                           |     23  1.0|
      Mixed Cell Focus                     |                                                       X                  |      2     |
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Periportal, Inflammation, Chronic    |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy                      | 1                    1           1           1                           |     16  1.3|
      Artery, Inflammation, Chronic        |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acanthosis                           |                                                                          |      2  2.0|
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3|              |            |
                                           | 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Inflammation, Chronic         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Endothelium, Hyperplasia             |                                                 2                        |      1  2.0|
      Myocardium, Degeneration             | 2  1     3     1        1        2  3  1  1  3        2  2               |     32  1.6|
      Myocardium, Degeneration, Multifocal |       1              1                                                   |      3  1.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |    2     1              1        1     2                 1               |     13  1.5|
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                  2     2  2                              |      6  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  M  M  +  +  +  +  M  +  +  +  +  +               |  61        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Pars Distalis, Angiectasis           |                      3                                                   |      1  3.0|
      Pars Distalis, Cyst                  |    X                             X                                       |      6     |
      Pars Distalis, Hyperplasia           |    1                 3              3                    3               |     12  2.3|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      C-Cell, Hyperplasia                  | 3  2  1  2           1  1  1     3  2  2     3  2     3  3               |     52  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  62        |
      Inflammation, Chronic                | 1  2                                2                 2                  |     16  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3|              |            |
                                           | 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cervix, Epithelium, Hyperplasia      |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |    2                                   2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Femoral, Atrophy                     |       4                                                                  |      1  4.0|
      Femoral, Hyperplasia, Re Cell        |                   1           1                    2                     |     10  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inguinal, Sinus, Ectasia             |                                                                          |      1  3.0|
      Mediastinal, Sinus, Ectasia          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +               |  68        |
      Infiltration Cellular, Histiocyte    |                   1           1                    1                     |      9  2.0|
      Sinus, Ectasia                       |                                     3                                    |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    1                                            3                        |      4  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      2  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  64        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Hyperplasia, Cystic                  | 2              2                 2           3        1  1               |     17  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Osteopetrosis                        |                                                                          |      1  3.0|
      Femur, Osteopetrosis                 |       4                    3                                             |      2  3.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3|              |            |
                                           | 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infarct                              |                                                                          |      3  2.7|
      Hypothalamus, Compression            | 3        3              1              2                                 |     10  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Interstitium, Inflammation, Chronic  | 2                                                                        |      3  1.7|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic, Multifocal              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   2        |
      Lens, Cataract                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +           +                    +                     |   8        |
      Inflammation, Chronic, Multifocal    |                   1           1                    1                     |      7  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Nephropathy                          | 2  2     2  1  1        1        2  2  2  3  2        2  1               |     38  1.4|
      Nephropathy, Multifocal              |       1              1     1                                             |      7  1.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 0| 0| 4| 4| 0| 4| 0| 4| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 2| 1| 6| 2| 3| 0| 0| 9| 9| 5| 7| 9| 5| 9| 5| 2| 2| 2| 9| 1|             
                                           | 9| 6| 6| 9| 9| 9| 1| 6| 9| 1| 8| 1| 3| 5| 6| 6| 5| 6| 3| 6| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    150 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +  +           A              +  +  +     +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Parasite Metazoan                    |             X                                                  X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                          2     2         |             
      Basophilic Focus                     | X  X  X  X  X  X  X     X  X              X        X     X  X  X  X      |             
      Clear Cell Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                         X                          X           X         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |    1  1                    1              2                          1   |             
      Mixed Cell Focus                     |             X                                                            |             
      Necrosis, Coagulative                |                               3  1                                       |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic        |          2                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Cyst                                 |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Ulcer                                |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Atrium, Thrombosis                   |                               X                                          |             
      Myocardium, Degeneration             | 1        2  1  1  2  1  1  2     1                             1  1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Hyperplasia                          | 2           2  1     1  2  1                 4                 1        1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 0| 0| 4| 4| 0| 4| 0| 4| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 2| 1| 6| 2| 3| 0| 0| 9| 9| 5| 7| 9| 5| 9| 5| 2| 2| 2| 9| 1|             
                                           | 9| 6| 6| 9| 9| 9| 1| 6| 9| 1| 8| 1| 3| 5| 6| 6| 5| 6| 3| 6| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    150 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Hyperplasia                          |                               2                                         4|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Pars Distalis, Angiectasis           |             2              2     4                                       |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                 2  2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      C-Cell, Hyperplasia                  |          3  2     1     2  3  2                             3  2  2     1|             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +  M  +  +  +  +  +           +              +  +  +     +|             
      Inflammation, Chronic                | 1           1  2     1                                                  1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |             1                                                            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Hyperplasia, Plasma Cell             |                                  2                                       |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Hyperplasia, Cystic                  | 1        2           2  1        2           2                    3     1|             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 0| 0| 4| 4| 0| 4| 0| 4| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 2| 1| 6| 2| 3| 0| 0| 9| 9| 5| 7| 9| 5| 9| 5| 2| 2| 2| 9| 1|             
                                           | 9| 6| 6| 9| 9| 9| 1| 6| 9| 1| 8| 1| 3| 5| 6| 6| 5| 6| 3| 6| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    150 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Osteopetrosis                        | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Alveolus, Inflammation, Subacute     |                                  3           3                           |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
      Nares, Inflammation, Suppurative     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +        +  +     +     +  +  +  +     +|             
      Nephropathy                          | 2        1  1  3  1  1  1  1  1  1           1              1  2  1     1|             
      Nephropathy, Multifocal              |    1  1                                            1     1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +  +  +  +  +  +  +           +              +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 9| 1| 2| 3| 1| 3| 5| 6| 3| 5| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 5| 9| 0| 5| 1| 6| 2| 0| 6| 0| 0| 0| 0| 6| 0| 6| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    150 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  A  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Ulcer                                |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Parasite Metazoan                    |    X                                   X        X                 X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                     2                             3  1   |             
      Basophilic Focus                     | X  X  X     X  X  X     X  X     X  X  X  X     X     X  X  X     X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                               X                 X        X               |             
      Hyperplasia                          |                                        2                 2               |             
      Inflammation, Granulomatous          |                   1     1  1           1  2     2  1                    1|             
      Mixed Cell Focus                     |                                                                   X      |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Inflammation, Chronic                |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Acinus, Atrophy                      |          1                                   1  1           2            |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Ulcer                                |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Ulcer                                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Atrium, Thrombosis                   |                               X                                          |             
      Myocardium, Degeneration             | 2  2  1     1  1  2  1  1     1  2        1     2     1  1  2  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia                          |       1     1           2     1                          1     1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 9| 1| 2| 3| 1| 3| 5| 6| 3| 5| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 5| 9| 0| 5| 1| 6| 2| 0| 6| 0| 0| 0| 0| 6| 0| 6| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    150 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          X                                                               |             
      Pars Distalis, Hyperplasia           | 2                                               1  1              2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |          1     3  2           2  3        3  1           1  2  2  1  2   |             
      Follicle, Dilatation                 |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic                |    1        2        1           1        1                    3         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Cyst                                 |                                                 X              X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Dilatation                           | 3                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia, Plasma Cell             |                      2                                                   |             
      Sinus, Ectasia                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +     +  +     +  +  +  +     +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                               2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +     +  +     +  M  +  +     +  +  +  M  +  M   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia, Cystic                  |    3                                   2     2        1  4  2  2  1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 9| 1| 2| 3| 1| 3| 5| 6| 3| 5| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 5| 9| 0| 5| 1| 6| 2| 0| 6| 0| 0| 0| 0| 6| 0| 6| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    150 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Osteopetrosis                        |       3     2        3                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Infarct                              |                      3                                                   |             
      Hypothalamus, Compression            |                      4  1                 2  3           4  1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
      Nares, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Lens, Cataract                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  2        1  1     1     1  2     2  2  2  1     1  2  1  1  2  1   |             
      Nephropathy, Multifocal              |                            1        1              1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +     +  +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 0| 7| 7| 0| 6| 7| 7| 5| 7| 0| 7| 6| 7| 7| 0| 7| 0|              |            |
                             DAY ON TEST   | 5| 0| 3| 9| 3| 3| 9| 4| 3| 3| 2| 0| 9| 3| 0| 3| 3| 9| 3| 9|              |            |
                                           | 6| 8| 1| 3| 1| 1| 4| 3| 1| 1| 2| 0| 5| 1| 0| 1| 1| 3| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    150 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  47        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Parasite Metazoan                    |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  61        |
      Angiectasis, Focal                   |                                                                          |      5  2.0|
      Basophilic Focus                     | X     X     X  X     X  X  X           X     X  X     X                  |     45     |
      Clear Cell Focus                     |                         X              X              X                  |      3     |
      Hepatodiaphragmatic Nodule           |                                              X                           |      7     |
      Hyperplasia                          |                            2                                             |      3  2.0|
      Inflammation, Granulomatous          |       1        1                                                         |     15  1.2|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis, Coagulative                |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Acinus, Atrophy                      |       1                 1                                                |      6  1.2|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Cyst                                 |                            X                                             |      1     |
      Ulcer                                |                               2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Ulcer                                |    2                                                                     |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Atrium, Thrombosis                   |                                                                          |      2     |
      Myocardium, Degeneration             |    2  2     1        2     2           2     1  1     2                  |     39  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 0| 7| 7| 0| 6| 7| 7| 5| 7| 0| 7| 6| 7| 7| 0| 7| 0|              |            |
                             DAY ON TEST   | 5| 0| 3| 9| 3| 3| 9| 4| 3| 3| 2| 0| 9| 3| 0| 3| 3| 9| 3| 9|              |            |
                                           | 6| 8| 1| 3| 1| 1| 4| 3| 1| 1| 2| 0| 5| 1| 0| 1| 1| 3| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    150 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Hyperplasia                          |             1                 1                                          |     18  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Hyperplasia                          |             1                             2     1                        |      6  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +     +  +     M  +  +  +  +     +  +  +  +     +                  |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  53        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.7|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                            2     1        2  2  2                        |     12  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      C-Cell, Hyperplasia                  |       2        2        1  2  2  1        1  2  2     2                  |     32  1.9|
      Follicle, Dilatation                 |                            1                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  49        |
      Inflammation, Chronic                |    2  1        1                       1  2  1                           |     17  1.4|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Cyst                                 |                         X                                                |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  51        |
      Dilatation                           |       2                                                                  |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |                                        2                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  51        |
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.0|
      Sinus, Ectasia                       |                      1                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 0| 7| 7| 0| 6| 7| 7| 5| 7| 0| 7| 6| 7| 7| 0| 7| 0|              |            |
                             DAY ON TEST   | 5| 0| 3| 9| 3| 3| 9| 4| 3| 3| 2| 0| 9| 3| 0| 3| 3| 9| 3| 9|              |            |
                                           | 6| 8| 1| 3| 1| 1| 4| 3| 1| 1| 2| 0| 5| 1| 0| 1| 1| 3| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    150 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Fibrosis                             |                                           1                              |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +     M  +     +  +  +  +  +     +  +  +  +     +                  |  49        |
      Hyperplasia, Cystic                  |    2  2                    1  3  2     3  2  1        3                  |     25  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Osteopetrosis                        |                         3                                                |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Infarct                              |    3                                                                     |      2  3.0|
      Hypothalamus, Compression            |                                                                          |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Alveolus, Inflammation, Subacute     |                                                                          |      2  3.0|
      Interstitium, Inflammation, Chronic  |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
      Nares, Inflammation, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  60        |
      Nephropathy                          |    1  1     1  1     1  2  2  1        1     1  2     1                  |     45  1.3|
      Nephropathy, Multifocal              | 2                                                                        |      8  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +  +     +  +  +  +  +     +  +  +  +     +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 0| 4| 7| 7| 6| 7| 4| 7| 6| 7| 7| 0| 6| 7| 7| 3| 4| 7| 4| 0|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 9| 5| 0| 2| 1| 2| 5| 2| 6| 2| 2| 9| 5| 2| 2| 9| 5| 2| 5| 9|             
                                           | 9| 6| 9| 6| 1| 6| 6| 7| 9| 9| 9| 6| 9| 2| 9| 9| 6| 2| 9| 9| 7| 6| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Parasite Metazoan                    |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |       X     X        X  X                 X  X     X  X  X     X  X      |             
      Clear Cell Focus                     |                         X                                                |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                          2               |             
      Inflammation, Granulomatous          | 1  1     1                    1  1     1  1     1              1     2   |             
      Mixed Cell Focus                     | X                       X                    X        X  X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Acinus, Atrophy                      |                               1     1                    1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +        +  +  M  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Ulcer                                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Ulcer                                |                                                                          |             
      Mucosa, Mineralization               |       1                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Myocardium, Degeneration             | 2           2           1     1           2  2     2     2  1            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 0| 4| 7| 7| 6| 7| 4| 7| 6| 7| 7| 0| 6| 7| 7| 3| 4| 7| 4| 0|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 9| 5| 0| 2| 1| 2| 5| 2| 6| 2| 2| 9| 5| 2| 2| 9| 5| 2| 5| 9|             
                                           | 9| 6| 9| 6| 1| 6| 6| 7| 9| 9| 9| 6| 9| 2| 9| 9| 6| 2| 9| 9| 7| 6| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Hyperplasia                          |             3                 1     1        1           2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +        +  +  +  +     +  +  +  +     +  +  M  +     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Necrosis, Liquifactive               |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                      X     X                                             |             
      Pars Distalis, Hyperplasia           | 3     3     1                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      C-Cell, Hyperplasia                  |       2              2  2  3  1     2  1  2  2     2              2      |             
      Follicle, Dilatation                 |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Inflammation, Chronic                | 1     2     1        1     1  1     1                 2  1        2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Cyst                                 |                                                                          |             
      Follicle, Cyst                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Dilatation                           |                                                                          |             
      Hemorrhage                           | 3                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +        +  +  M  +     +  +  +  +     +  +  +  +     +      |             
      Hyperplasia, Plasma Cell             |                                     2                                    |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     +        +  +  +  +     +  +  M  +     +  +  M  +     +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 0| 4| 7| 7| 6| 7| 4| 7| 6| 7| 7| 0| 6| 7| 7| 3| 4| 7| 4| 0|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 9| 5| 0| 2| 1| 2| 5| 2| 6| 2| 2| 9| 5| 2| 2| 9| 5| 2| 5| 9|             
                                           | 9| 6| 9| 6| 1| 6| 6| 7| 9| 9| 9| 6| 9| 2| 9| 9| 6| 2| 9| 9| 7| 6| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Cystic                  |       3                    1  2     3        1     1     4               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                               4        4                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
      Foreign Body                         |                                                             2            |             
      Inflammation, Granulomatous          |                            1                                1            |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                         1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Cyst                                 |       X                                                                  |             
      Nephropathy                          | 1     2     2        1  2  1  2     2  1  1  1     1  1  2        1      |             
      Nephropathy, Multifocal              |    1                             1                                   1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +        +  +  +  +     +  +  +  +     +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 0| 7| 7| 6| 7| 4| 7| 0| 6| 7| 0| 6| 3| 0| 7| 7| 7| 7| 4| 7| 0| 7|             
                             DAY ON TEST   | 2| 3| 5| 9| 2| 3| 2| 3| 5| 3| 9| 9| 3| 9| 8| 8| 9| 3| 3| 3| 3| 5| 0| 9| 3|             
                                           | 3| 5| 6| 3| 9| 0| 8| 0| 6| 0| 5| 6| 0| 4| 2| 3| 4| 0| 0| 0| 0| 6| 4| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +     +|             
      Basophilic Focus                     |    X  X     X  X     X     X        X              X  X  X  X  X  X     X|             
      Clear Cell Focus                     |                X                                      X                  |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |             2                                      2                     |             
      Inflammation, Granulomatous          |       1     1  1        2              2              1     1  2         |             
      Mixed Cell Focus                     |             X                                               X            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                       +                                                |             
      Inflammation, Chronic                |                         2                                                |             
      Fat, Necrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Acinus, Atrophy                      | 1                                1  2     1                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Ulcer                                | 2                                2                                       |             
      Mucosa, Mineralization               |                                                             1            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Myocardium, Degeneration             | 2           2  1     1     2                 1     1  1           2     2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 0| 7| 7| 6| 7| 4| 7| 0| 6| 7| 0| 6| 3| 0| 7| 7| 7| 7| 4| 7| 0| 7|             
                             DAY ON TEST   | 2| 3| 5| 9| 2| 3| 2| 3| 5| 3| 9| 9| 3| 9| 8| 8| 9| 3| 3| 3| 3| 5| 0| 9| 3|             
                                           | 3| 5| 6| 3| 9| 0| 8| 0| 6| 0| 5| 6| 0| 4| 2| 3| 4| 0| 0| 0| 0| 6| 4| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Hyperplasia                          | 1                                         1                             1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +     +     +|             
      Necrosis, Liquifactive               |                                                                   2      |             
      Pars Distalis, Angiectasis           |                      3                                                   |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           |       1           2     1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      C-Cell, Hyperplasia                  |    2        1  2  1  3     2     3  2     3        2  2  2               |             
      Follicle, Dilatation                 |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Inflammation, Chronic                | 1  1        2  2     1           2  1     2           2  3  1     1      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Cyst                                 |                                  X                                       |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Dilatation                           |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Mediastinal, Sinus, Ectasia          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |                                  2                                2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Sinus, Ectasia                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Granulomatous          |                                                       1     3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        M  M  +  +     +     +  +     +  +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 0| 7| 7| 6| 7| 4| 7| 0| 6| 7| 0| 6| 3| 0| 7| 7| 7| 7| 4| 7| 0| 7|             
                             DAY ON TEST   | 2| 3| 5| 9| 2| 3| 2| 3| 5| 3| 9| 9| 3| 9| 8| 8| 9| 3| 3| 3| 3| 5| 0| 9| 3|             
                                           | 3| 5| 6| 3| 9| 0| 8| 0| 6| 0| 5| 6| 0| 4| 2| 3| 4| 0| 0| 0| 0| 6| 4| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Cystic                  |                3  2              3        4        1                    3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Infarct                              |                                           2                              |             
      Hypothalamus, Compression            |    4           2           1              3                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1  2        1  2     1     2        1     1        1  1  2  1     1     3|             
      Nephropathy, Multifocal              |                         1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +  +  +     +     +  +     +  +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3|              |            |
                                           | 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    |                X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +               |  61        |
      Basophilic Focus                     | X  X  X     X           X  X  X        X     X  X  X     X               |     37     |
      Clear Cell Focus                     |                                                 X                        |      4     |
      Eosinophilic Focus                   |                X                                                         |      1     |
      Fatty Change                         |                                     2                                    |      1  2.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation, Granulomatous          |                      2                 1     1           1               |     22  1.2|
      Mixed Cell Focus                     |                X              X                                          |      9     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                          +                  |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis                        |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Acinus, Atrophy                      |             1  1                                1        1               |     11  1.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ulcer                                |                                     2                                    |      3  2.0|
      Mucosa, Mineralization               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
      Acanthosis                           |                                        2                                 |      1  2.0|
      Hyperkeratosis                       |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   2        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                    3                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3|              |            |
                                           | 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Myocardium, Degeneration             | 2     1     2  2              1     1  2     1  1     2  2               |     30  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia                          |                                  3                 1                     |     10  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Necrosis, Liquifactive               |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |    X                                                                     |      4     |
      Pars Distalis, Hyperplasia           |                         3                 2              3               |      9  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Hyperplasia                  | 3     2     3  2        2  2  2  2  2        2  3  2  2  3               |     37  2.1|
      Follicle, Dilatation                 |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Inflammation, Chronic                | 1  1                    2           2  1                 1               |     28  1.4|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Cyst                                 |                                                                          |      1     |
      Follicle, Cyst                       |             X                                                            |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Dilatation                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3|              |            |
                                           | 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sinus, Ectasia                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Sinus, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Depletion Lymphoid                   |                                           3                              |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  M               |  49        |
      Hyperplasia, Cystic                  |    3  1        2        3        2  3           1  1  4                  |     22  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Osteopetrosis                        |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Infarct                              |                                                                          |      1  2.0|
      Hypothalamus, Compression            | 2           2                    4  1                 4                  |     11  2.8|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Alveolus, Inflammation, Subacute     |                                           2                              |      1  2.0|
      Interstitium, Inflammation, Chronic  |    1        1                                                            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                    +                                                |   3        |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Lens, Cataract                       |                         3                                                |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3|              |            |
                                           | 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 3  1  1     1  1        1  1  1  1  3  2     1  1  1  2  1               |     45  1.4|
      Nephropathy, Multifocal              |                   1                                                      |      5  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|             
                                           | 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X        X     X  X        X  X        X           X     X  X  X  X|             
      Clear Cell Focus                     |                         X                                               X|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                                      X                                 |             
      Hyperplasia                          |                                                    2                     |             
      Inflammation, Granulomatous          |                            1  3        1  1                              |             
      Mixed Cell Focus                     |                         X                                X  X            |             
      Necrosis, Coagulative                |                                                                          |             
      Periportal, Inflammation, Chronic    |             1                                                            |             
      Serosa, Hemorrhage                   |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1                       1                    1     1        1            |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                             4        1   |             
      Epithelium, Acanthosis, Diffuse      |                                                                          |             
      Epithelium, Hyperkeratosis, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                      1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration             | 1  1           3     2  1                                   1     1  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|             
                                           | 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Degeneration, Multifocal |       2                       1                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                         1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                                     |             
      Pars Distalis, Degeneration, Cystic  |                                        1                                 |             
      Pars Distalis, Hyperplasia           |                      3                             3                 2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  1        2        2  1  1  2  3  1     1     1     1           2   |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1     3  2                                2     1  2     2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Re Cell        |          1  1                             1     1     2                  |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Sinus, Ectasia               |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |          3  3                             2     1     3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|             
                                           | 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sinus, Ectasia                       |                      2                                               2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                    2     2  3  2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                             4     1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Foreign Body                         |                                                                          |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active, Multifocal       |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nares, Inflammation, Suppurative     | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
      Inflammation, Chronic, Focal         |                                                 1                        |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                      2   |             
      Nephropathy                          | 2  1           2     1  2           1              1     1  3  1  2      |             
      Nephropathy, Multifocal              |                   1           2        2     2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|             
                                           | 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|             
                                           | 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X              X                       X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X        X  X     X  X  X  X  X     X  X  X  X  X  X            |             
      Clear Cell Focus                     |                                              X  X     X                 X|             
      Degeneration, Cystic                 |                      1                                                   |             
      Eosinophilic Focus                   |                X                                   X        X            |             
      Fatty Change                         |             3        2                                         2         |             
      Hepatodiaphragmatic Nodule           |                X                 X  X                       X            |             
      Hyperplasia                          |                               1                                          |             
      Inflammation, Granulomatous          |                                        1                             1  1|             
      Mixed Cell Focus                     |    X           X  X           X                    X  X                  |             
      Necrosis, Coagulative                |                                                                          |             
      Periportal, Inflammation, Chronic    |                                                                          |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2                                      1  1                 1         |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
      Ulcer                                |                                                                4         |             
      Epithelium, Acanthosis, Diffuse      |                                                                          |             
      Epithelium, Hyperkeratosis, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Ulcer                                |             3                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration             | 2  1     2     1     1     1  1              1  1  1     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|             
                                           | 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Degeneration, Multifocal |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  3     2  4  2  1  2     2        1              3                    1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                       2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                 X  X                    X|             
      Pars Distalis, Degeneration, Cystic  |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2                 2     2           2     2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1           2  3  2  1  2  1  2  2  1     1  4  2  4  3  1              2|             
      Follicle, Dilatation                 |                2                                               1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic                | 1     2        1     1  2           1        1                 1        1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Re Cell        |                                                                      2   |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Sinus, Ectasia               |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|             
                                           | 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sinus, Ectasia                       |                                        1                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             2              3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    1              3     2  2  2  2     2        2  3  2                 1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            | 4     2        2  4  4        3  4     3                       4         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                         2                                                |             
      Foreign Body                         |                         2                                                |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                               1                                   1      |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nares, Inflammation, Suppurative     |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                            +         |             
      Lens, Cataract                       |                                                                3         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
      Inflammation, Chronic, Focal         |                                                                      1   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3  2  2  2  1  2  2  3  1  1  3  1  2  2  1  2  2  1  1     2  2        2|             
      Nephropathy, Multifocal              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|             
                             DAY ON TEST   | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|             
                                           | 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3|              |            |
                                           | 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  69        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basophilic Focus                     |    X  X           X        X  X  X  X  X              X                  |     38     |
      Clear Cell Focus                     |    X  X                                                  X               |      9     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      3     |
      Fatty Change                         |                                                                          |      3  2.3|
      Hepatodiaphragmatic Nodule           |                                     X                                    |      7     |
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Granulomatous          |          2  1     1                 1        1  1     1                  |     14  1.2|
      Mixed Cell Focus                     |    X  X                          X              X                        |     13     |
      Necrosis, Coagulative                |                      1                                                   |      1  1.0|
      Periportal, Inflammation, Chronic    |                                                                          |      1  1.0|
      Serosa, Hemorrhage                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acinus, Atrophy                      |    1     1                 1                 1     1  1                  |     15  1.1|
      Artery, Inflammation, Chronic        |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                |                                                    3                     |      2  2.5|
      Ulcer                                |                                                                          |      3  3.0|
      Epithelium, Acanthosis, Diffuse      |             2                                                            |      1  2.0|
      Epithelium, Hyperkeratosis, Diffuse  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                    1                     |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3|              |            |
                                           | 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Myocardium, Degeneration             | 2  1  2                    1  2                 1     1  2               |     27  1.4|
      Myocardium, Degeneration, Multifocal |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |                            1  2                    2     1               |     16  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          |                            1                                             |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Pars Distalis, Cyst                  |                            X                          X                  |      6     |
      Pars Distalis, Degeneration, Cystic  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |    3  3                    1     4              1  2                     |     14  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      C-Cell, Hyperplasia                  | 2  2     1        2        3  2  4  1  1        1  1  2                  |     43  1.8|
      Follicle, Dilatation                 |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Inflammation, Chronic                | 2     2           1              1                 1  1                  |     22  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 | X     X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Dilatation                           |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Femoral, Hyperplasia, Re Cell        |             1  1                          2                              |      9  1.3|
      Femoral, Myelofibrosis               |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3|              |            |
                                           | 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Sinus, Ectasia               |                                                    2                     |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                    2                     |      1  2.0|
      Pancreatic, Hyperplasia, Plasma Cell |                                                    2                     |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Sinus, Ectasia                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +               |  68        |
      Infiltration Cellular, Histiocyte    |             2  1        3                 3                              |     10  2.2|
      Sinus, Ectasia                       |                                                    2                     |      4  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hematopoietic Cell Proliferation     |                            3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Hyperplasia, Cystic                  | 3                    1     3     2              1  1  2  2               |     24  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hypothalamus, Compression            |                               1              4           2               |     14  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Abscess                              |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Alveolus, Inflammation, Subacute     | 2                                                                        |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      2  1.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active, Multifocal       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Nares, Inflammation, Suppurative     |                                                    3                     |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3|              |            |
                                           | 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    600 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +                           |   3        |
      Lens, Cataract                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +                     |   3        |
      Inflammation, Chronic, Focal         |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  1           1  1     1  2              1  1  1  1  2               |     45  1.6|
      Nephropathy, Multifocal              |          2                          2  2                                 |      8  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|             
                             DAY ON TEST   | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|             
                                           | 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                                            |             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          4                                                               |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                             X            |             
      Basophilic Focus                     |                                     X                       X  X         |             
      Clear Cell Focus                     |                                                                         X|             
      Degeneration, Cystic                 |    1                                   2     1                           |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Granulomatous          |                   1                                                      |             
      Necrosis, Coagulative                |                                                             3            |             
      Periportal, Inflammation, Chronic    |                                                       1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                      +                              |             
      Inflammation, Chronic                |                                           2                              |             
      Fat, Necrosis                        |    4                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                  1           1                           |             
      Artery, Inflammation, Chronic        | 2           1                       2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal, Subacute        |                                                       2                  |             
      Mineralization                       |             2                                                            |             
      Ulcer                                |                                                    3                     |             
      Epithelium, Acanthosis, Focal        |                                                       2                  |             
      Epithelium, Hyperkeratosis, Focal    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1                             2                                 |             
      Inflammation, Focal, Subacute        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|             
                             DAY ON TEST   | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|             
                                           | 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                3                 1                 1              3      |             
      Mucosa, Hyperplasia, Focal           |                                                       2                  |             
      Mucosa, Mineralization               |             3     1              1                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             | 2  1        3                    2           3  3  3        2  1  3     2|             
      Myocardium, Degeneration, Multifocal |                   1  1                                                   |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |       1                 1                             2  1           2   |             
      Myocardium, Inflammation, Suppurative|                                                    2                     |             
      Myocardium, Mineralization           |             2                                                            |             
      Valve, Inflammation, Chronic Active  |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |          2                       1                             1         |             
      Hyperplasia, Nodular                 |                                                       1                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                 3     2                     |             
      Infarct                              |                                                                   4      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |             4                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |             1                       2                                   1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2           3  1  1     1  1  2  2  1     2     4              1     3|             
      Follicle, Dilatation                 |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|             
                             DAY ON TEST   | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|             
                                           | 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1        3  2  2  1        2     2  1  2  1  2     3           2  2     2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   1           1                                          |             
      Inflammation, Suppurative            | 2  1           2                 2        4     1  1              3     1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           3                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                           4                              |             
      Interstitial Cell, Hyperplasia       |                                                 2                        |             
      Seminiferous Tubule, Atrophy         |    4                       4                 4                           |             
      Seminiferous Tubule, Hypoplasia      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       2                 2                             1              1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                           3                              |             
      Fibrosis                             |                                  2                 2                     |             
      Hematopoietic Cell Proliferation     |                                           3                              |             
      Infarct                              |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  M  M  +  M  +  +|             
      Hyperplasia, Cystic                  |    1     2  1  3                 1              2  1                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |             X                                                            |             
      Synovial Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|             
                             DAY ON TEST   | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|             
                                           | 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                              4                           |             
      Infarct                              |                3           2                                             |             
      Hypothalamus, Compression            |    4                                            4                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchus, Foreign Body, Single       |                         1                                                |             
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |             
           Multifocal                      |                                                          1               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Mineralization         |             2                                                            |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic, Multifocal              |       1                 1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Nares, Inflammation, Suppurative     |                2                                                         |             
      Sinus, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
      Middle Ear, Abscess                  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Mineralization               |             2                                                            |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
      Inflammation, Chronic, Multifocal    |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                           1                              |             
      Inflammation, Suppurative            |                                                    3                     |             
      Nephropathy                          | 4  3     3  4  3           3     2  3  2  1  3  2  2        2  2  2     2|             
      Nephropathy, Multifocal              |                   1  1        1                                          |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Chronic, Multifocal             |       1                                               1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                           4                              |             
      Inflammation, Suppurative            |                                                                          |             
      Lumen, Hemorrhage                    |                         2                                1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|             
                                           | 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   3      |             
      Ulcer                                |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                           X              X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Mineralization                       |                                  3                                       |             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Basophilic Focus                     | X     X        X     X                 X                          X      |             
      Clear Cell Focus                     | X              X                                                         |             
      Degeneration, Cystic                 |                            1        1  1     2                           |             
      Eosinophilic Focus                   |                                     X                                    |             
      Inflammation, Granulomatous          |    1  1                                                     1            |             
      Necrosis, Coagulative                |                            1                                             |             
      Periportal, Inflammation, Chronic    |             1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2           2                 1                          1      |             
      Artery, Inflammation, Chronic        |                2     2           2     1                          1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |             1                                                            |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Mineralization                       |                                  2                                       |             
      Ulcer                                |                                              4                           |             
      Epithelium, Acanthosis, Focal        |             2                                                            |             
      Epithelium, Hyperkeratosis, Focal    |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                               1   |             
      Inflammation, Focal, Subacute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|             
                                           | 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia, Focal           |                                                                          |             
      Mucosa, Mineralization               |                            2     3                                2      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
      Acanthosis                           |                            3                                             |             
      Hyperkeratosis                       |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                                       |             
      Aorta, Mineralization                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Dilatation                   |          4                                                               |             
      Atrium, Thrombosis                   |                                                                X         |             
      Myocardium, Degeneration             | 3     2  2     3     2     3     2  1  1           1  1           2  1   |             
      Myocardium, Degeneration, Multifocal |                         1                                                |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |             2     1           1           1                              |             
      Myocardium, Inflammation, Suppurative|                                                                          |             
      Myocardium, Mineralization           |                                  3                                       |             
      Valve, Inflammation, Chronic Active  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                2                                                  2      |             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     4              1              1        1                           |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3           3                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 2        3           1                 1                       1     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  2     2     3        1           4  2     2           3  1  2  2  1   |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|             
                                           | 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     2  2     1     2  1  2     1     2     2              1  2  2  2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Suppurative            | 1  1                             2  1  1                          1  1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
      Interstitial Cell, Hyperplasia       |    2                                                                     |             
      Seminiferous Tubule, Atrophy         |       4                    4     4  4                                4   |             
      Seminiferous Tubule, Hypoplasia      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                           1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                   1                       2                             3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |                            4     4     2                       2  1  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                  X                                X      |             
      Synovial Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|             
                                           | 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchus, Foreign Body, Single       |                                                                          |             
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                      2   |             
      Interstitium, Mineralization         |                                  2                                       |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic, Multifocal              |                   1                                                     1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Nares, Inflammation, Suppurative     |                                                                          |             
      Sinus, Inflammation, Chronic Active  |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             
      Middle Ear, Abscess                  |                4                                                         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Inflammation, Chronic, Multifocal    |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 4  1  2  2     3     2     4     4  3  4     4                 3  4  3   |             
      Nephropathy, Multifocal              |                         1                                1  1            |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Chronic, Multifocal             |             1                                                           1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5|              |            |
                                           | 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Edema                                |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Bacterium                            |                                                                          |      1     |
      Basophilic Focus                     |             X  X     X        X     X        X     X                     |     16     |
      Clear Cell Focus                     |             X                                                            |      4     |
      Degeneration, Cystic                 | 1           1                                   1                        |     10  1.2|
      Eosinophilic Focus                   |                                     X                                    |      2     |
      Inflammation, Granulomatous          |                      1     1     1                                       |      7  1.0|
      Necrosis, Coagulative                |                                                                          |      2  2.0|
      Periportal, Inflammation, Chronic    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                     3                                    |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acinus, Atrophy                      |    2              1  1  1           1  1     1  2     2  1               |     16  1.3|
      Artery, Inflammation, Chronic        |             1  2           1  4     1              2                     |     14  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5|              |            |
                                           | 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Acanthosis, Focal        |                                                                          |      2  2.0|
      Epithelium, Hyperkeratosis, Focal    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                |                                                                          |      4  1.5|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Ulcer                                |                                           2     2     2  2               |      8  2.0|
      Mucosa, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Mucosa, Mineralization               |       3                                                                  |      7  2.1|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Acanthosis                           |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Atrium, Dilatation                   |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
      Myocardium, Degeneration             |       3     2  2     2     3        3  2  2  1     1                     |     34  2.1|
      Myocardium, Degeneration, Multifocal |          2              1        1                                       |      6  1.2|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      9  1.3|
      Myocardium, Inflammation, Suppurative|                                                                          |      1  2.0|
      Myocardium, Mineralization           |                                                                          |      2  2.5|
      Valve, Inflammation, Chronic Active  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Hyperplasia                          |                      1     1                          1                  |      8  1.4|
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          | 1                          1                       2     3               |     12  1.9|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +               |  64        |
      Hyperplasia                          |       4                                                                  |      4  3.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5|              |            |
                                           | 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |             2                                                            |     10  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      C-Cell, Hyperplasia                  | 2  1     1  2  2  1  3  1  2  2  1  1  2     3     3  1  1               |     43  1.9|
      Follicle, Dilatation                 |    2  2                                                                  |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                | 1  1  2  1  2  2        1  1        2  2     2  2  2  2  2               |     44  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  68        |
      Inflammation, Chronic                |                   1     1                                                |      5  1.0|
      Inflammation, Suppurative            |    2                 1                 2     2  1     1  1               |     23  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  69        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       | 2                             2                                          |      4  2.0|
      Seminiferous Tubule, Atrophy         |                4           4                    4        4               |     12  4.0|
      Seminiferous Tubule, Hypoplasia      |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                  1                                       |      1  1.0|
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia, Lymphoid                |                                  2                                       |      1  2.0|
      Hyperplasia, Plasma Cell             |                                     2                                    |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  68        |
      Infiltration Cellular, Histiocyte    |                                                                          |      7  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis                             |    1                                                                     |      4  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5|              |            |
                                           | 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +               |  62        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  +  +  +  M  +  M  +  M  M  +  +  +  +  M  M               |  50        |
      Hyperplasia, Cystic                  | 1  2                                         1  2                        |     17  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Abscess                              |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Femur, Fibrous Osteodystrophy        |       X                                                                  |      4     |
      Synovial Tissue, Inflammation,       |                                                                          |            |
          Suppurative                      |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Gliosis                              |                                                                          |      1  4.0|
      Infarct                              |                                                          3               |      3  2.7|
      Hypothalamus, Compression            |    2                                                                     |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Bronchus, Foreign Body, Single       |                                                                          |      1  1.0|
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |                                                       2                  |      2  2.0|
      Interstitium, Mineralization         |                                                                          |      2  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic, Multifocal              |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fungus                               |                                                    X                     |      1     |
      Nares, Inflammation, Suppurative     |                                                 2  2                     |      3  2.0|
      Sinus, Inflammation, Chronic Active  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Middle Ear, Abscess                  |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5|              |            |
                                           | 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +           +                        |   3        |
      Phthisis Bulbi                       |                                                 X                        |      1     |
      Cornea, Mineralization               |                                                                          |      1  2.0|
      Lens, Cataract                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic, Multifocal    |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy                          | 2  3  4     2  2     2     2  1     3  2  1  2  1  1  2  2               |     47  2.5|
      Nephropathy, Multifocal              |          1        1     1        1                                       |     10  1.0|
      Interstitial Tissue, Inflammation,   |                                                                          |            |
           Chronic, Multifocal             |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  69        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Inflammation, Suppurative            |       3                                                                  |      1  3.0|
      Lumen, Hemorrhage                    |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|             
                             DAY ON TEST   | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|             
                                           | 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     M|             
      Edema                                |       3                                                                  |             
      Parasite Metazoan                    |                                                 X        X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Ulcer                                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Ulcer                                | 4                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                            X        X     X        X        X            |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |    1                       1     1     1           1           1         |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                               3                                          |             
      Hepatodiaphragmatic Nodule           |                         X        X                                       |             
      Hyperplasia                          |                                                          3               |             
      Mixed Cell Focus                     |                                                                X         |             
      Necrosis, Coagulative                |                                                                          |             
      Sinusoid, Congestion                 |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                       +                                          |             
      Fat, Necrosis                        |       2                       3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Acinus, Atrophy                      |       1                    1        2  1        2        1     1  2      |             
      Artery, Inflammation, Chronic        |                      2     1                                   1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Inflammation, Chronic                |                               2           2                              |             
      Ulcer                                | 4                                                                 2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Ulcer                                |                                                                          |             
      Mucosa, Mineralization               |    4                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Pulp, Inflammation, Suppurative      |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|             
                             DAY ON TEST   | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|             
                                           | 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Aorta, Mineralization                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Myocardium, Degeneration             | 2  3  2     3     2  2        2     4  1  3  2  1        2  3  3  4      |             
      Myocardium, Degeneration, Multifocal |          2              2                          2                     |             
      Myocardium, Mineralization           |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Hyperplasia                          |                      1     2  2           2     2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Hyperplasia                          | 3  4              4                 1                       3            |             
      Infarct                              |                                                                   4      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +     +  +     M  +  +  +  +  +  +  +        +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      C-Cell, Hyperplasia                  | 2           2              3  2  2  2  2     2  3        3  3  2  1      |             
      Follicle, Dilatation                 |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                                                                         1|             
      Inflammation, Suppurative            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Hyperplasia                          | 2                                                                        |             
      Inflammation, Chronic                | 3  1  1     3        2     1  2  1     2  2     1        1     2  1      |             
      Duct, Dilatation                     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +     +  +  +  +  +  +  +  M        +  +  +  +     +|             
      Inflammation, Suppurative            | 2  1        1                 2           1                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +     +  +  +  +  +  M  +  +        +  +  +  +     +|             
      Inflammation, Suppurative            |                               3                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|             
                             DAY ON TEST   | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|             
                                           | 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                               2                                          |             
      Seminiferous Tubule, Atrophy         |    4        4                                            4        4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Mediastinal, Sinus, Ectasia          |                                        2                                 |             
      Renal, Sinus, Ectasia                |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     M  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Hyperplasia, Plasma Cell             | 2                                                                        |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Sinus, Ectasia                       |       3                                         2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Fibrosis                             |                            2                    2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     M     +  +     +  M  M  +  +  +  +  +        +  +  +  +     +|             
      Atrophy                              |                                                                          |             
      Ectopic Parathyroid Gland            |       X                                                                  |             
      Ectopic Thyroid                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +     M  M     +  M  +  +  +  +  +  +        M  +  +  M     +|             
      Hyperplasia, Cystic                  | 2                                         2  2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Abscess                              |                                                                          |             
      Cyst Epithelial Inclusion            |                                           X                              |             
      Ulcer                                |                               2                                          |             
      Epidermis, Acanthosis                |                                              2                           |             
      Epidermis, Hyperkeratosis            |                                              4                           |             
      Hair Follicle, Hyperkeratosis        |                                                                         3|             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Femur, Fibrous Osteodystrophy        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|             
                             DAY ON TEST   | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|             
                                           | 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Infarct                              |                   3                                                      |             
      Hypothalamus, Compression            | 3                             4           1  2                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Lumbar, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Mineralization         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                 +      |             
      Lens, Cataract                       |                                                                   4      |             
      Sclera, Mineralization               | 2                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +        +  +  +  +     +|             
      Cyst                                 |                                              X                           |             
      Nephropathy                          | 3  4  4     3     1  1     3  3  3  3  2  4  3  4        3  2  4  3     1|             
      Nephropathy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +     +  +  +  +  +  +  +  M        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|             
                             DAY ON TEST   | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|             
                                           | 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                                     X     X        X                 X   |             
      Clear Cell Focus                     |                                  X        X           X  X           X   |             
      Degeneration, Cystic                 |                                                       1                  |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                3         |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Hyperplasia                          |                                                 4                        |             
      Mixed Cell Focus                     |                                  X        X        X                     |             
      Necrosis, Coagulative                |                         4                    1                           |             
      Sinusoid, Congestion                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +                                                               |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Acinus, Atrophy                      |    1        1           1                                1              2|             
      Artery, Inflammation, Chronic        |                                           1        2           4         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |       2                                                                 2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Ulcer                                |       1     2        1                                                  2|             
      Mucosa, Mineralization               |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Suppurative      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|             
                             DAY ON TEST   | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|             
                                           | 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
      Aorta, Mineralization                |                                                                3         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Myocardium, Degeneration             | 2  3     2  2        3  2        1  3  2  1     2  2  3  3  2  3        1|             
      Myocardium, Degeneration, Multifocal |                   1           2              1                           |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Angiectasis                          |                                              2                           |             
      Ectopic Tissue                       |                                                                          |             
      Hyperplasia                          |       1                             2     2        1  1                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Hyperplasia                          |                         1                 2     2                       1|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Hyperplasia                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia           |    3     1                                                               |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      C-Cell, Hyperplasia                  |    2  1  3  2        2           2  2     2     3     2     1           1|             
      Follicle, Dilatation                 |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Hyperplasia                          |                                              2        3                  |             
      Inflammation, Chronic                |    1  1     4           1        1  1        2  1  1  2  2     2         |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Inflammation, Suppurative            |             1        2           1                 1        4  1        2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +        +  +        +  +  +  +     +  +  +  +  +  +        +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|             
                             DAY ON TEST   | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|             
                                           | 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |       4                          4              4  4     4              4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Renal, Sinus, Ectasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Hyperplasia, Plasma Cell             |    2                                                                     |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  M        +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                              2                           |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Fibrosis                             |                                                 2        2               |             
      Hematopoietic Cell Proliferation     |                                        3     2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Atrophy                              |                                              3                           |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Ectopic Thyroid                      |                                                                          |             
      Inflammation, Chronic                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +        +  +        +  +  +  M  +  +  +  +  +  +  M        +|             
      Hyperplasia, Cystic                  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Abscess                              | 2                                                                        |             
      Cyst Epithelial Inclusion            |                                     X                          X         |             
      Ulcer                                |                                                                          |             
      Epidermis, Acanthosis                |                                                                          |             
      Epidermis, Hyperkeratosis            |                                                                          |             
      Hair Follicle, Hyperkeratosis        |                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Femur, Fibrous Osteodystrophy        |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|             
                             DAY ON TEST   | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|             
                                           | 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150 PPM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
      Lumbar, Atrophy                      |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Interstitium, Inflammation, Chronic  |                                  1                                       |             
      Interstitium, Mineralization         |                                                                1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Sclera, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +        +  +  +  +  +  +  +  +  +  +  +        +|             
      Cyst                                 |          X                                                               |             
      Nephropathy                          | 1  2  2  4  2        1  2        3  2     2     3  3  3  4  1  4        2|             
      Nephropathy, Multifocal              |                                              1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +        +  +  A  +  +  +  +  +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6|              |            |
                             DAY ON TEST   | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5|              |            |
                                           | 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  49        |
      Edema                                |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Edema                                |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +        +  +     +  +  +  +  +  +  +  +  +  +               |  56        |
      Angiectasis, Focal                   |                         3                    2                           |      2  2.5|
      Basophilic Focus                     |                      X           X        X  X        X                  |     14     |
      Clear Cell Focus                     |                                  X                                       |      6     |
      Degeneration, Cystic                 |                                                                          |      7  1.0|
      Eosinophilic Focus                   |                               X           X           X                  |      3     |
      Fatty Change                         |                                                                          |      2  3.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      4     |
      Hyperplasia                          |                                           2                              |      3  3.0|
      Mixed Cell Focus                     |                                              X     X                     |      6     |
      Necrosis, Coagulative                |                                                                          |      2  2.5|
      Sinusoid, Congestion                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Acinus, Atrophy                      |    1  1                 1        1  1              1                     |     19  1.2|
      Artery, Inflammation, Chronic        |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Ulcer                                |                                     2           2                        |      6  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Ulcer                                |                                     3           3                        |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6|              |            |
                             DAY ON TEST   | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5|              |            |
                                           | 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Mineralization               |                         4                                                |      3  3.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Pulp, Inflammation, Suppurative      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +                                                |   3        |
      Aorta, Mineralization                |                         3                                                |      3  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Myocardium, Degeneration             |    2                    3     3  2  2  1  1  3     1  2  3               |     44  2.3|
      Myocardium, Degeneration, Multifocal |                            1                                             |      7  1.6|
      Myocardium, Mineralization           |                         3                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Ectopic Tissue                       |                                        X                                 |      1     |
      Hyperplasia                          |    1                    2     2           2                              |     14  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Hyperplasia                          |       1                 2        2           1        3                  |     14  2.1|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M                 +     +  +  +  +  +  +  +  +  +  +               |  47        |
      Hyperplasia                          |                         2           3                                    |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +              +  +     +  +  +  +  +  +  +  +  +  +               |  52        |
      Pars Distalis, Cyst                  |                         X                                                |      2     |
      Pars Distalis, Hyperplasia           |                         2           2        3                           |      5  2.2|
      Pars Intermedia, Cyst                |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Hyperplasia                  |    3  2                       3  3     2  1              2               |     32  2.1|
      Follicle, Dilatation                 |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Granuloma Sperm                      |                                           3                              |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6|              |            |
                             DAY ON TEST   | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5|              |            |
                                           | 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Chronic                |    2  1                 2     2  1  1  2  2  2  2  1  2  1               |     39  1.6|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  M                 +     +  +  +  +  +  +  +  +  +  +               |  49        |
      Inflammation, Suppurative            |                         1           3     1  1  1                        |     17  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  M                 +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Inflammation, Suppurative            |                                     3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |       3                 4     4           4        4                     |     15  3.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  2.0|
      Renal, Sinus, Ectasia                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Plasma Cell             |                               2                                          |      2  2.0|
      Sinus, Ectasia                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  M                 +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Sinus, Ectasia                       |                         3                                                |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Fibrosis                             |                         3           2                                    |      6  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                  3                                       |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +                 +     +  +  +  +  M  +  +  +  +  +               |  47        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Ectopic Thyroid                      |                                                 X                        |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  +                 M     +  +  +  +  M  +  +  +  +  M               |  38        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6|              |            |
                             DAY ON TEST   | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5|              |            |
                                           | 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                     1                                    |      5  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Abscess                              |                                                       3                  |      2  2.5|
      Cyst Epithelial Inclusion            |                                                                          |      3     |
      Ulcer                                |                                                                          |      1  2.0|
      Epidermis, Acanthosis                |                                                                          |      1  2.0|
      Epidermis, Hyperkeratosis            |                                                                          |      1  4.0|
      Hair Follicle, Hyperkeratosis        |                                                                          |      1  3.0|
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Femur, Fibrous Osteodystrophy        |                         X                                                |      3     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Infarct                              |                                                                          |      1  3.0|
      Hypothalamus, Compression            |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Lumbar, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Interstitium, Inflammation, Chronic  |                         1                                                |      2  1.0|
      Interstitium, Mineralization         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Sclera, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +                 +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Cyst                                 |                                                                          |      2     |
      Nephropathy                          |    3  3                 4     3  3  4  3  4  3  2  3  3  2               |     49  2.8|
      Nephropathy, Multifocal              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6|              |            |
                             DAY ON TEST   | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5|              |            |
                                           | 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    150 PPM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  M                 +     +  +  +  +  +  +  +  +  +  +               |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|             
                             DAY ON TEST   | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|             
                                           | 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +        +  +  +  +  A  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +        +  +  +  +  A  +     +        +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                                 X           X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +        +  +  +  +  A  +     +        +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +        +  +  +  +  A  +     +        +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +        +  +  +  +  A  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +        +  +  +  +  A  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +   |             
      Bacterium                            |                                                                X         |             
      Basophilic Focus                     |                                           X  X        X                  |             
      Clear Cell Focus                     |                                           X              X               |             
      Degeneration, Cystic                 | 1     1                 1  1  1                    1                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Hyperplasia                          |                                                                4         |             
      Inflammation, Granulomatous          | 1                                                                        |             
      Mixed Cell Focus                     |                         X     X           X        X  X                  |             
      Necrosis, Coagulative                |                               2                                3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                       +         |             
      Fat, Necrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Ectopic Tissue                       |                                                             X            |             
      Acinus, Atrophy                      |                   1                 2        2        1        1         |             
      Artery, Inflammation, Chronic        |                   3     1     3                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Periductular, Fibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Acanthosis                           |                               2                                          |             
      Hyperkeratosis                       |                               2                                          |             
      Inflammation, Chronic                |       2                                                                  |             
      Mineralization                       |                                                 1                        |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperkeratosis, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                2     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|             
                             DAY ON TEST   | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|             
                                           | 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Mineralization               | 4                             2                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                                        |             
      Aorta, Mineralization                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |          2                                                               |             
      Myocardium, Degeneration             | 3     3           2  3  3  2  2     2        2  1  2  2  2     3  2  1   |             
      Myocardium, Degeneration, Multifocal |    1     2                                1                              |             
      Myocardium, Mineralization           | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |       2              2  1     1     1                    1           1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                      2  1     2              2           1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          | 4                             2                                      1   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Hyperplasia           |                                                 1              2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |       1           3     3           2        2  2  2  2  2  3  1     3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                      2                                   3               |             
      Inflammation, Chronic                | 1     1        1  2  1  2  1  2              1     2     3  1  2  4  1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                               X                                          |             
      Inflammation, Suppurative            |       1              1        2     1                       2  1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|             
                             DAY ON TEST   | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|             
                                           | 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +   |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                              2                           |             
      Renal, Ectasia                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                      2   |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  M  +   |             
      Artery, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        M  +  +  +  +  M     M        +  M  +  M  +  +  M  M  M   |             
      Hyperplasia, Cystic                  |                      1                             1                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Femur, Fibrous Osteodystrophy        | X                             X                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Infarct                              |                            2                                   4         |             
      Hypothalamus, Compression            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|             
                             DAY ON TEST   | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|             
                                           | 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Mineralization         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Nares, Foreign Body                  |                                                                          |             
      Nares, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Necrotizing    |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 4     4        2  2  3  3  2  4     3        2  2  3  3  3  3  4  4  4   |             
      Nephropathy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +        +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +   |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|             
                                           | 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Dilatation                           |                                                       4                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Parasite Metazoan                    |       X                                         X        X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +     +  +  +  +           +     +  +  +  +  +  +     +   |             
      Bacterium                            |                                                                          |             
      Basophilic Focus                     |       X                                                                  |             
      Clear Cell Focus                     |       X                                               X                  |             
      Degeneration, Cystic                 |                                                    2     1               |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                                             |             
      Hyperplasia                          |    3                                                                     |             
      Inflammation, Granulomatous          |                      1        1                             1            |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis, Coagulative                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Fat, Necrosis                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Ectopic Tissue                       |                                                                          |             
      Acinus, Atrophy                      |       1  1              2     1                 1        1               |             
      Artery, Inflammation, Chronic        |                            1  2           3     3  1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Periductular, Fibrosis               | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +        +  +  +     +     +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +        +  +  +     +     +     +  +  +  +     +     +   |             
      Acanthosis                           |                                           2                              |             
      Hyperkeratosis                       |                                           2                              |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperkeratosis, Focal    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|             
                                           | 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Mineralization               |                                           3        3                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
      Aorta, Mineralization                |                                           3                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +        +     +  +  +  +  +  +     +   |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Myocardium, Degeneration             | 3  2  2  3     1           2              3        2  2  1     2     1   |             
      Myocardium, Degeneration, Multifocal |                   1                                         1            |             
      Myocardium, Mineralization           |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Hyperplasia                          |       1  1     1                                   2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Hyperplasia                          | 1  2  2        2              1           2        4                 2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Hyperplasia                          |                               2           3        4                 2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +        +  +  M           +     +  +  +  +     +     +   |             
      Pars Distalis, Hyperplasia           |                                                    2     1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      C-Cell, Hyperplasia                  |       2  2     2        2  2                    2     3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Hyperplasia                          |                               3                                          |             
      Inflammation, Chronic                |       1  1     1        2  2  3           3     2  3     2           2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            | 1                       1                          2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|             
                                           | 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +        +     +  +  +  +     +     +   |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         | 3  4                    4                          4  3              4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +        +  +  M           +     +  +  +  +     +     +   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Fibrosis                             |    1                                               2                     |             
      Hematopoietic Cell Proliferation     |                1                                                         |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +        M  +  +           +     +  +  +  +     +     M   |             
      Artery, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +     +        M  +  +           +     +  +  +  +     +     +   |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Abscess                              |                                                 3                        |             
      Ulcer                                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Femur, Fibrous Osteodystrophy        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Infarct                              |                                                    3     2               |             
      Hypothalamus, Compression            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Alveolus, Inflammation, Subacute     |                                                       2                  |             
      Interstitium, Inflammation, Chronic  |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|             
                                           | 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Mineralization         |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Nares, Foreign Body                  |                                                       2                  |             
      Nares, Inflammation, Suppurative     |                                           2           2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Inflammation, Subacute               |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Necrotizing    |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +        +  +  +  +        +     +  +  +  +     +     +   |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 4  3  3  3     4        2  2  3           4     3  4  3  3     3     3   |             
      Nephropathy, Multifocal              |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +        +  +  +           +     +  +  +  +     +     +   |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6|              |            |
                             DAY ON TEST   | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3|              |            |
                                           | 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Dilatation                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  M  +  +  +  +     +  +  +  +  +  +  +     +  +               |  48        |
      Parasite Metazoan                    |                                  X                                       |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +               |  55        |
      Bacterium                            |                                                                          |      1     |
      Basophilic Focus                     |                            X                                             |      5     |
      Clear Cell Focus                     |                                           X                              |      5     |
      Degeneration, Cystic                 |          1  1                                                            |     10  1.1|
      Eosinophilic Focus                   |             X                                X                           |      2     |
      Hepatodiaphragmatic Nodule           |                                        X  X                              |      4     |
      Hyperplasia                          |    3           2                                      3                  |      5  3.0|
      Inflammation, Granulomatous          |                   2                                                      |      5  1.2|
      Mixed Cell Focus                     |                               X  X           X                           |      9     |
      Necrosis, Coagulative                |       3                                                                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   4        |
      Fat, Necrosis                        |                                     3                                    |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Ectopic Tissue                       |                                                                          |      1     |
      Acinus, Atrophy                      |    1  1  1                          1           1        1               |     17  1.2|
      Artery, Inflammation, Chronic        |    2                                         2                           |     11  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Periductular, Fibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  51        |
      Acanthosis                           |             2                                                            |      3  2.0|
      Hyperkeratosis                       |             2                                                            |      3  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6|              |            |
                             DAY ON TEST   | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3|              |            |
                                           | 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |       2                                2                                 |      2  2.0|
      Epithelium, Hyperkeratosis, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
      Ulcer                                |       2                                2                                 |      4  2.0|
      Mucosa, Mineralization               |    3     3  1                                                            |      7  2.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   3        |
      Aorta, Mineralization                |    3                                                                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrium, Thrombosis                   |                X                                                         |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Myocardium, Degeneration             |    3  3  4  2  2  2     2     3  3  2     1  2  2        3               |     42  2.2|
      Myocardium, Degeneration, Multifocal |                            2                                             |      6  1.3|
      Myocardium, Mineralization           |          3                                                               |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Hyperplasia                          |    1        2  1              3     3  1                 1               |     18  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Hyperplasia                          |    1           3              1                                          |     16  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Hyperplasia                          |    3  2  4  3                                                            |     11  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  49        |
      Pars Distalis, Hyperplasia           |          1                    2                       1                  |      7  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      C-Cell, Hyperplasia                  |       3     2                 3     2  2     1  2     1  2               |     28  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6|              |            |
                             DAY ON TEST   | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3|              |            |
                                           | 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Inflammation, Chronic                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Hyperplasia                          |                                                                          |      3  2.7|
      Inflammation, Chronic                |    2  2  2  3  1  1  2  2        2     2  2  2  1     2                  |     40  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Suppurative            |    3        2                                         1  2               |     13  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  56        |
      Interstitial Cell, Hyperplasia       |                                                          1               |      1  1.0|
      Seminiferous Tubule, Atrophy         |    4           4              4        2  4                              |     12  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                           4                              |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Hyperplasia, Plasma Cell             |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  M  +  +  +  +  +  M     +  +  +  +  +  +  +     +  +               |  47        |
      Infiltration Cellular, Histiocyte    |                   2                                                      |      1  2.0|
      Sinus, Ectasia                       |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Fibrosis                             |             2                       2                                    |      4  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  M     +  +  +  +  +  +  +     +  +               |  46        |
      Artery, Mineralization               |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  M  M  +  M  +  +  M     +  +  +  +  +  +  +     +  M               |  35        |
      Hyperplasia, Cystic                  |    2                                   1              1                  |      5  1.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Abscess                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6|              |            |
                             DAY ON TEST   | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3|              |            |
                                           | 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    300 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Femur, Fibrous Osteodystrophy        |    X  X                                                                  |      5     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Infarct                              |                   3                    3                                 |      6  2.8|
      Hypothalamus, Compression            |                                                          3               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Alveolus, Inflammation, Subacute     |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                  1        2                              |      3  1.3|
      Interstitium, Mineralization         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Nares, Foreign Body                  |                                                                          |      1  2.0|
      Nares, Inflammation, Suppurative     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   1        |
      Cornea, Inflammation, Necrotizing    |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +               |  52        |
      Cyst                                 |                            X  X                                          |      2     |
      Nephropathy                          |    4  4  4  4  3  2  1  3     4  2  2  2  3  3  4     1  4               |     50  3.0|
      Nephropathy, Multifocal              |                            1                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +               |  50        |
      Ectasia                              |          4                                                               |      1  4.0|
      Hemorrhage                           |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|             
                             DAY ON TEST   | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|             
                                           | 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |       X     X        X        X           X           X           X     X|             
      Clear Cell Focus                     |          X                                         X                     |             
      Degeneration, Cystic                 |          1                                                  1     1      |             
      Eosinophilic Focus                   |       X     X        X  X                             X           X      |             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                                X            |             
      Hyperplasia                          |       3  3           2                 2                 4               |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |       X     X        X              X                 X           X      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                             +           +                  |             
      Inflammation, Chronic                |                                                       3                  |             
      Pigmentation, Hemosiderin            |             2                                                            |             
      Fat, Necrosis                        |                                           3                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                        X                                 |             
      Acinus, Atrophy                      |                   1                       2                       1      |             
      Artery, Inflammation, Chronic        |       4                       1                          1        2      |             
      Duct, Ectasia                        |                                                       1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Cytoplasmic   |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Acinus, Parotid Gland, Vacuolization |                                                                          |             
          Cytoplasmic, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      2              2                             3      |             
      Hyperkeratosis                       |                      2              2                             3      |             
      Inflammation, Chronic                |          2           2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|             
                             DAY ON TEST   | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|             
                                           | 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |          2                                                               |             
      Mucosa, Mineralization               |                         4                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
      Aorta, Inflammation, Chronic, Focal  |                   1                                                      |             
      Aorta, Inflammation, Chronic         |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration             |       1  3  2        3  2  1        1                    2           3   |             
      Myocardium, Degeneration, Multifocal |                                              2     1  2                 3|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                   1                             1              1         |             
      Myocardium, Mineralization           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           2  1                                         2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                  3               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                            3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       1                                                                  |             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       3     3        3  2  1  3     2  1  1  2        1  2  1     3     1|             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2  2  2        3  2     2  1        1  1        1  2  2     2  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|             
                             DAY ON TEST   | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|             
                                           | 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |          2  1        1     1        1     1              1  1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                           2                              |             
      Interstitial Cell, Right, Hyperplasia|                                                                          |             
      Seminiferous Tubule, Atrophy         |                      4                                   4           4   |             
      Seminiferous Tubule, Right, Atrophy  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    3           2  3              2                             1         |             
      Sinus, Ectasia                       |                         3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2                                                  2               |             
      Infarct                              |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Arteriole, Giant Cell                |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  M  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          3                             1  3                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Epidermis, Acanthosis                |                                                                          |             
      Epidermis, Hyperkeratosis            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                         X                                                |             
      Femur, Osteopetrosis                 |                                                    3                     |             
      Synovial Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
      Tarsal, Fracture Healed              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|             
                             DAY ON TEST   | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|             
                                           | 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                     3                                    |             
      Infarct                              |                                                             3            |             
      Inflammation, Suppurative            |                               3                                          |             
      Hypothalamus, Compression            |          2                                2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolus, Hemorrhage, Multifocal     | 2                                                                        |             
      Alveolus, Inflammation, Subacute     |                               2                                          |             
      Artery, Mineralization, Focal        |                                  1                                       |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                      1   |             
      Peribronchial, Inflammation, Chronic,|                                                                          |             
           Focal                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Nares, Inflammation, Suppurative     |                                                          3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                             +                              |             
      Cornea, Mineralization               |                                           1                              |             
      Lens, Cataract                       |             4                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |       4  4  3        4  4  2  4     1  1  1              4  1     2  4   |             
      Nephropathy, Multifocal              |                                              1     1  1                 1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|             
                             DAY ON TEST   | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|             
                                           | 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Edema                                |                                     3                                    |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                     4                                    |             
      Basophilic Focus                     | X           X  X     X     X     X     X              X     X           X|             
      Clear Cell Focus                     |       X                       X     X                       X            |             
      Degeneration, Cystic                 |                   1  1              1                          1         |             
      Eosinophilic Focus                   |                      X                 X                                 |             
      Fibrosis, Focal                      |                                     2                                    |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |          4     3        4        3                                       |             
      Inflammation, Granulomatous          |             1                                   1                        |             
      Mixed Cell Focus                     | X                                                     X     X        X   |             
      Necrosis, Coagulative                |                                                                1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +  +           +  +            |             
      Inflammation, Chronic                |                                              3                           |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Fat, Necrosis                        |                                     3                       2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Acinus, Atrophy                      | 1           1  1     1     1  1  1  1                                    |             
      Artery, Inflammation, Chronic        |          1                       1                    1                  |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Cytoplasmic   |                                                                          |             
          Alteration, Focal                |    1                                                                     |             
      Acinus, Parotid Gland, Vacuolization |                                                                          |             
          Cytoplasmic, Focal               |    1                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|             
                             DAY ON TEST   | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|             
                                           | 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                 1                    3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                2                                               1         |             
      Mucosa, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                         +|             
      Aorta, Inflammation, Chronic, Focal  |                                                                          |             
      Aorta, Inflammation, Chronic         |                                                                         2|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration             | 3        3     2  3  3     3     3  3  3  3     2  4  2     1  1         |             
      Myocardium, Degeneration, Multifocal |       2                       3              1                          3|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                          1  1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       1              1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2     2                 2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 4                        |             
      Pars Distalis, Cyst                  |                               3                                          |             
      Pars Distalis, Hyperplasia           |             1           4                                                |             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4        2  2  2  1  3  3  2  2  3     2     2  2           2  2     2  1|             
      Follicle, Dilatation                 |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2     1  2  2     2  2  1  2     1  2  2  4  1  2  1  2  1  1  2     2  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|             
                             DAY ON TEST   | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|             
                                           | 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              1                           |             
      Inflammation, Suppurative            |          1        1        1     3                    1  1           1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Interstitial Cell, Right, Hyperplasia|                                                                          |             
      Seminiferous Tubule, Atrophy         |                   4                                                      |             
      Seminiferous Tubule, Right, Atrophy  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Sinus, Ectasia          |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          1                                            2                  |             
      Infarct                              |                                                                4     3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  M  +  +  +  M  M  M  M  +|             
      Arteriole, Giant Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                1  2                             1                    2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage                           |                                                          1               |             
      Epidermis, Acanthosis                |                                  3                                       |             
      Epidermis, Hyperkeratosis            |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                           2                              |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
      Synovial Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
      Tarsal, Fracture Healed              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|             
                             DAY ON TEST   | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|             
                                           | 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Hypothalamus, Compression            |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |             2                                                            |             
      Alveolus, Hemorrhage, Multifocal     |                                                                          |             
      Alveolus, Inflammation, Subacute     |                                                                          |             
      Artery, Mineralization, Focal        |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                    2        2           2|             
      Peribronchial, Inflammation, Chronic,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Nares, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic, Multifocal    |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 3        3  2  4  4  3  3  3     4  3  3  3     2  4  4  1  2  1     4   |             
      Nephropathy, Multifocal              |       1                       1              1                          1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7|              |            |
                             DAY ON TEST   | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2|              |            |
                                           | 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Ulcer                                |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Edema                                |                                                                          |      1  3.0|
      Parasite Metazoan                    |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  67        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Angiectasis, Focal                   |                                                                          |      1  4.0|
      Basophilic Focus                     |       X     X                 X              X  X                        |     23     |
      Clear Cell Focus                     |       X  X  X     X                    X                                 |     11     |
      Degeneration, Cystic                 |                         1                                                |      8  1.0|
      Eosinophilic Focus                   |          X                                                               |      9     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      3     |
      Hyperplasia                          | 3                                                                        |     10  3.1|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Mixed Cell Focus                     |          X  X     X              X                                       |     14     |
      Necrosis, Coagulative                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                                                               |  10        |
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Fat, Necrosis                        |       4  3                                                               |      5  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Ectopic Tissue                       |                                                                          |      1     |
      Acinus, Atrophy                      |          1           1  1  1           1  1                              |     17  1.1|
      Artery, Inflammation, Chronic        |          1              3        1  1     1                              |     12  1.5|
      Duct, Ectasia                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Acinus, Parotid Gland, Cytoplasmic   |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  1.0|
      Acinus, Parotid Gland, Vacuolization |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7|              |            |
                             DAY ON TEST   | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2|              |            |
                                           | 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Acanthosis                           |                                              2                           |      4  2.3|
      Hyperkeratosis                       |                                              2                           |      4  2.3|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Ulcer                                |                                                                          |      3  1.7|
      Mucosa, Mineralization               |                         3                    3  2                        |      4  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +                                                |   3        |
      Aorta, Inflammation, Chronic, Focal  |                                                                          |      1  1.0|
      Aorta, Inflammation, Chronic         |                                                                          |      1  2.0|
      Aorta, Mineralization                |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Myocardium, Degeneration             |    1  1  2  2  2     3     1        2  2  2     2        2               |     36  2.2|
      Myocardium, Degeneration, Multifocal |                   2           1                                          |     10  2.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      3  1.0|
      Myocardium, Mineralization           |                         3                    3                           |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia                          | 1        1  2           2  1     3        2                              |     14  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +               |  69        |
      Hyperplasia                          |          1                                               2               |      6  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hyperplasia                          |          1              4                    3                           |      8  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Abscess                              |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           | 1        2                 2                                             |      6  1.8|
      Pars Distalis, Hyperplasia, Nodular  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7|              |            |
                             DAY ON TEST   | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2|              |            |
                                           | 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  | 1        2        2  2     1  1  3     2  3  2  3     2                  |     44  2.0|
      Follicle, Dilatation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  67        |
      Inflammation, Chronic                |          2  2  2        2  2     1  1  2  3  3        1  2               |     47  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |    1     1              1  1     2                    1  1               |     22  1.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Interstitial Cell, Right, Hyperplasia|                                                    4                     |      1  4.0|
      Seminiferous Tubule, Atrophy         | 4                                4        4                              |      7  4.0|
      Seminiferous Tubule, Right, Atrophy  |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Sinus, Ectasia                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Infiltration Cellular, Histiocyte    |                                                                          |      5  2.2|
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fibrosis                             |                      2        2        1  2                              |      8  1.8|
      Infarct                              | 4                                                                        |      4  3.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Arteriole, Giant Cell                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M               |  57        |
      Hyperplasia, Cystic                  |                                  3                                       |      8  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7|              |            |
                             DAY ON TEST   | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2|              |            |
                                           | 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Cyst Epithelial Inclusion            |                                              X                           |      1     |
      Hemorrhage                           |                                                                          |      1  1.0|
      Epidermis, Acanthosis                |                                                                          |      1  3.0|
      Epidermis, Hyperkeratosis            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Osteopetrosis                        |                                                                          |      1  2.0|
      Femur, Fibrous Osteodystrophy        |                         X                                                |      2     |
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
      Synovial Tissue, Inflammation,       |                                                                          |            |
          Suppurative                      | 3                                                                        |      1  3.0|
      Tarsal, Fracture Healed              |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Infarct                              |                3                                                         |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Hypothalamus, Compression            |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Alveolus, Hemorrhage, Multifocal     |                                                                          |      1  2.0|
      Alveolus, Inflammation, Subacute     |                                                 2                        |      2  2.0|
      Artery, Mineralization, Focal        |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                    1                     |      1  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      4  1.8|
      Peribronchial, Inflammation, Chronic,|                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fungus                               |       X                                                                  |      1     |
      Nares, Inflammation, Suppurative     |       2                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05087-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 15:56:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7|              |            |
                             DAY ON TEST   | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2|              |            |
                                           | 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Mineralization               |                                                                          |      1  1.0|
      Lens, Cataract                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                        X                                 |      1     |
      Nephropathy                          | 2  1  2  4  3        4  4  3     2  3  3  2  4  1     2  3               |     49  2.8|
      Nephropathy, Multifocal              |                   1           1                                          |     10  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Lumen, Hemorrhage                    |                                                    1                     |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
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                             ----------              END OF REPORT             ----------                                           
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