Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1200

TDMS Study 05090-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              COUMARIN


NTP Experiment-Test: 05090-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 06:23:02




       Facility:  American Biogenics Corp.

       Chemical CAS #:  91-64-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 18           20           19           19                                     
  Early Deaths                                                                                                                      
    Dead                                               7            5            3           13                                     
    Moribund                                           8            5            5            8                                     
    Gavage Death                                       4                         1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           39           42           28                                     
    Moribund                                                        1                                                               
  Animals Examined Microscopically                    60           58           58           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (46)         (48)         (50)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Intestine Small, Jejunum                           (49)         (46)         (48)         (50)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Liver                                              (58)         (50)         (53)         (59)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Basophilic Focus                                 2 (3%)       1 (2%)                    4 (7%)                                
      Clear Cell Focus                                                           1 (2%)       2 (3%)                                
      Congestion                                                                              3 (5%)                                
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Developmental Malformation                       1 (2%)                                                                       
      Eosinophilic Focus                               4 (7%)      21 (42%)     22 (42%)      9 (15%)                               
      Fatty Change                                                  1 (2%)                    1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                8 (14%)      2 (4%)       1 (2%)       3 (5%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Inflammation, Suppurative                                     2 (4%)       2 (4%)       1 (2%)                                
      Mineralization                                                                          3 (5%)                                
      Mixed Cell Focus                                              1 (2%)       1 (2%)                                             
      Necrosis, Coagulative                            3 (5%)       2 (4%)       2 (4%)      11 (19%)                               
      Pigmentation                                     1 (2%)                                                                       
      Syncytial Alteration                                                       2 (4%)      23 (39%)                               
      Vacuolization Cytoplasmic                                                               3 (5%)                                
      Bile Duct, Cyst                                                            1 (2%)                                             
      Centrilobular, Hypertrophy                                                             25 (42%)                               
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Hyperplasia                                                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (7)          (6)          (3)          (4)                                    
      Cyst                                             1 (14%)                                                                      
      Fat, Necrosis, Coagulative                       5 (71%)      3 (50%)      2 (67%)      4 (100%)                              
   Pancreas                                           (56)         (48)         (48)         (54)                                   
      Atrophy                                          2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Infiltration Cellular, Lymphocyte               10 (18%)      4 (8%)       9 (19%)     10 (19%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Necrosis, Coagulative                            1 (2%)                    1 (2%)                                             
   Pharynx                                                         (1)                                                              
      Cyst                                                          1 (100%)                                                        
   Salivary Glands                                    (59)         (50)         (51)         (60)                                   
      Infiltration Cellular, Lymphocyte               22 (37%)     14 (28%)     16 (31%)     25 (42%)                               
   Stomach, Forestomach                               (56)         (50)         (50)         (55)                                   
      Hyperkeratosis                                                4 (8%)       1 (2%)                                             
      Hyperplasia, Squamous                                         2 (4%)       5 (10%)                                            
      Inflammation, Suppurative                                     2 (4%)                                                          
   Stomach, Glandular                                 (54)         (48)         (50)         (50)                                   
      Dilatation                                                                              1 (2%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                 1 (2%)                                
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (50)         (51)         (60)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)                    2 (3%)                                
      Necrosis, Zenkers                                                                       1 (2%)                                
      Nuclear Alteration                                                         1 (2%)                                             
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
      Artery, Mineralization                                                                  1 (2%)                                
      Perivascular, Inflammation, Chronic                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (57)         (47)         (48)         (60)                                   
      Corticomedullary Junction, Hemorrhage                         1 (2%)       1 (2%)                                             
      Corticomedullary Junction, Necrosis,                                                                                          
          Coagulative                                               1 (2%)                                                          
      Spindle Cell, Hyperplasia                       42 (74%)     13 (28%)     23 (48%)     24 (40%)                               
   Adrenal Gland, Cortex                              (57)         (47)         (47)         (60)                                   
      Clear Cell Focus                                                           1 (2%)                                             
      Cytoplasmic Alteration                                                     1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                                                2 (4%)       1 (2%)                                
      Necrosis, Coagulative                                         1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)                                 1 (2%)                                
      Corticomedullary Junction, Necrosis,                                                                                          
          Coagulative                                               1 (2%)                                                          
   Adrenal Gland, Medulla                             (57)         (47)         (48)         (59)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (57)         (48)         (48)         (56)                                   
      Atrophy                                                       1 (2%)                                                          
   Parathyroid Gland                                  (40)         (38)         (40)         (48)                                   
      Ectopic Thymus                                                                          1 (2%)                                
      Hyperplasia                                      1 (3%)                                                                       
   Pituitary Gland                                    (53)         (45)         (45)         (57)                                   
      Pars Distalis, Cyst                              2 (4%)                                 1 (2%)                                
      Pars Distalis, Hyperplasia                                    1 (2%)       1 (2%)       2 (4%)                                
   Thyroid Gland                                      (55)         (49)         (50)         (56)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia                                           2 (4%)       1 (2%)                                             
      Follicle, Cyst                                                1 (2%)       1 (2%)       1 (2%)                                
      Follicle, Dilatation                                          1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     2 (4%)       4 (8%)       6 (12%)      4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (2)          (1)                                                 
      Hemorrhage                                                    1 (50%)                                                         
      Abdominal, Necrosis, Coagulative                              1 (50%)                                                         
      Posterior, Abscess                                                         1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (52)         (52)         (60)                                   
      Hematocyst                                       2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
      Inflammation, Suppurative                        2 (3%)       2 (4%)                                                          
      Pigmentation, Ceroid                                                       1 (2%)                                             
      Bilateral, Corpus Luteum, Cyst                                                          1 (2%)                                
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
      Follicle, Cyst                                  13 (22%)     16 (31%)     15 (29%)      6 (10%)                               
      Follicle, Hematocyst                                                                    1 (2%)                                
   Uterus                                             (58)         (55)         (51)         (60)                                   
      Hydrometra                                      10 (17%)     10 (18%)      6 (12%)     12 (20%)                               
      Hyperplasia, Cystic                             31 (53%)     26 (47%)     35 (69%)     29 (48%)                               
      Inflammation, Suppurative                        3 (5%)       4 (7%)       2 (4%)       3 (5%)                                
      Endometrium, Hyperplasia, Cystic                                                        1 (2%)                                
   Vagina                                             (1)                                                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperkeratosis                                   1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (48)         (49)         (60)                                   
      Hyperplasia, Neutrophil                                                    1 (2%)                                             
      Myelofibrosis                                                              2 (4%)                                             
   Lymph Node                                         (57)         (49)         (49)         (59)                                   
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
      Pancreatic, Inflammation, Chronic Active                                                1 (2%)                                
   Lymph Node, Mandibular                             (55)         (47)         (49)         (53)                                   
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
   Lymph Node, Mesenteric                             (53)         (45)         (48)         (56)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       4 (9%)       7 (15%)      2 (4%)                                
      Hyperplasia, Macrophage                          1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
   Spleen                                             (58)         (48)         (48)         (57)                                   
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Developmental Malformation                                    2 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation Erythrocytic                 2 (4%)       1 (2%)                                             
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Hyperplasia, Lymphoid                            4 (7%)       5 (10%)      6 (13%)      1 (2%)                                
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Inflammation, Suppurative                        2 (3%)       1 (2%)                                                          
   Thymus                                             (51)         (44)         (49)         (51)                                   
      Atrophy                                          1 (2%)                    1 (2%)       3 (6%)                                
      Hyperplasia, Lymphoid                                         2 (5%)                    1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Necrosis, Coagulative                                                                   2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (48)         (50)         (59)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
      Duct, Dilatation                                              1 (2%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Skin                                               (59)         (51)         (56)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Alopecia                                         5 (8%)       5 (10%)      7 (13%)      5 (8%)                                
      Hyperkeratosis                                   1 (2%)                                                                       
      Foot, Inflammation, Suppurative                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                       (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (49)         (50)         (58)                                   
      Hypothalamus, Compression                        1 (2%)                                                                       
      Meninges, Infiltration Cellular, Lymphocyte                                             2 (3%)                                
      Thalamus, Compression                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (50)         (50)         (60)                                   
      Congestion                                       2 (3%)                                 1 (2%)                                
      Foreign Body                                     3 (5%)                                                                       
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            3 (5%)       2 (4%)       2 (4%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              4 (8%)       4 (8%)       4 (7%)                                
      Alveolus, Hemorrhage                             1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolus, Infiltration Cellular, Lymphocyte                                1 (2%)                                             
      Alveolus, Inflammation, Chronic                                            1 (2%)                                             
      Bronchiole, Inflammation, Suppurative                                                   1 (2%)                                
      Bronchiole, Epithelium, Hyperplasia                           1 (2%)                    4 (7%)                                
      Bronchiole, Epithelium, Necrosis                                                        3 (5%)                                
      Mediastinum, Foreign Body                        1 (2%)                                                                       
      Peribronchial, Inflammation, Suppurative                                                1 (2%)                                
      Peribronchiolar, Hemorrhage                      1 (2%)                                                                       
      Pleura, Inflammation, Suppurative                1 (2%)                    1 (2%)       1 (2%)                                
      Subpleura, Mineralization                                                  1 (2%)                                             
   Nose                                               (58)         (50)         (51)         (59)                                   
      Lumen, Inflammation, Suppurative                                           2 (4%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)                                                 
      Cataract                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (47)         (49)         (58)                                   
      Glomerulosclerosis                               2 (3%)       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                8 (14%)      5 (11%)      8 (16%)      6 (10%)                               
      Nephropathy                                                                             1 (2%)                                
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Collecting Tubule, Mineralization                                                       1 (2%)                                
      Collecting Tubule, Necrosis, Coagulative                                                1 (2%)                                
      Collecting Tubule, Pigmentation, Hemoglobin      1 (2%)                                                                       
      Cortex, Cyst Multilocular                                                               1 (2%)                                
      Cortex, Pigmentation, Bile                                    1 (2%)                                                          
      Pelvis, Infiltration Cellular, Lymphocyte        4 (7%)                                 9 (16%)                               
      Renal Tubule, Degeneration                                    1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (53)         (47)         (48)         (56)                                   
      Infiltration Cellular, Lymphocyte               27 (51%)     14 (30%)     23 (48%)     20 (36%)                               
      Inflammation, Suppurative                                     1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           19                                     
  Early Deaths                                                                                                                      
    Dead                                               5            3            1           11                                     
    Moribund                                           1                         6            3                                     
    Gavage Death                                       1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           47           42           37                                     
  Animals Examined Microscopically                    60           58           57           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (49)         (49)         (60)                                   
      Periesophageal Tissue, Edema                                               1 (2%)                                             
   Intestine Large, Cecum                             (57)         (47)         (49)         (51)                                   
      Hyperplasia, Lymphoid                            3 (5%)                    5 (10%)                                            
      Inflammation, Chronic                                                                   1 (2%)                                
      Necrosis, Coagulative                                                                   1 (2%)                                
   Intestine Large, Colon                             (56)         (50)         (49)         (52)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Small, Ileum                             (58)         (47)         (49)         (51)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
      Lymphoid Tissue, Inflammation, Suppurative       1 (2%)                                 1 (2%)                                
   Intestine Small, Jejunum                           (56)         (47)         (50)         (51)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid                                     1 (2%)                                             
   Liver                                              (60)         (54)         (56)         (60)                                   
      Angiectasis                                                                             2 (3%)                                
      Basophilic Focus                                 1 (2%)       4 (7%)       2 (4%)       3 (5%)                                
      Clear Cell Focus                                 4 (7%)       7 (13%)      8 (14%)     11 (18%)                               
      Congestion                                       1 (2%)                    1 (2%)       7 (12%)                               
      Developmental Malformation                                                              1 (2%)                                
      Eosinophilic Focus                               6 (10%)     15 (28%)     13 (23%)     15 (25%)                               
      Fatty Change                                     1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mixed Cell Focus                                 4 (7%)       3 (6%)       4 (7%)       1 (2%)                                
      Necrosis, Coagulative                            3 (5%)       1 (2%)                    8 (13%)                               
      Syncytial Alteration                                          7 (13%)     39 (70%)     56 (93%)                               
      Vacuolization Cytoplasmic                       13 (22%)      1 (2%)      11 (20%)      6 (10%)                               
      Centrilobular, Hypertrophy                       1 (2%)       2 (4%)      23 (41%)     52 (87%)                               
   Mesentery                                          (8)          (3)          (3)          (3)                                    
      Inflammation, Granulomatous                      1 (13%)                                                                      
      Fat, Hemorrhage                                                                         1 (33%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Chronic                       2 (25%)                                1 (33%)                               
      Fat, Inflammation, Suppurative                   1 (13%)                                                                      
      Fat, Necrosis, Coagulative                       4 (50%)      2 (67%)      1 (33%)      2 (67%)                               
      Fat, Necrosis, Liquifactive                      2 (25%)                                                                      
   Pancreas                                           (59)         (50)         (50)         (59)                                   
      Atrophy                                                       3 (6%)       1 (2%)       1 (2%)                                
      Degeneration                                                               1 (2%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)       3 (6%)       4 (7%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Necrosis, Coagulative                                         1 (2%)                                                          
      Polyarteritis                                                 1 (2%)                                                          
   Salivary Glands                                    (59)         (50)         (50)         (60)                                   
      Infiltration Cellular, Lymphocyte               16 (27%)     19 (38%)     14 (28%)     21 (35%)                               
   Stomach, Forestomach                               (58)         (49)         (50)         (56)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperkeratosis                                   2 (3%)       2 (4%)                                                          
      Hyperplasia, Squamous                            1 (2%)       3 (6%)       3 (6%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (56)         (48)         (50)         (53)                                   
      Infiltration Cellular, Lymphocyte                                          1 (2%)       1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                                          4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (59)         (49)         (49)         (59)                                   
      Spindle Cell, Hyperplasia                       12 (20%)     12 (24%)      6 (12%)     10 (17%)                               
   Adrenal Gland, Cortex                              (59)         (49)         (49)         (59)                                   
      Basophilic Focus                                                                        1 (2%)                                
      Clear Cell Focus                                 3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Cytomegaly                                       1 (2%)                                                                       
      Cytoplasmic Alteration                                        1 (2%)       1 (2%)                                             
      Hypertrophy                                      1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (50)         (50)         (59)                                   
      Hyperplasia                                      1 (2%)       3 (6%)       1 (2%)                                             
   Pituitary Gland                                    (52)         (46)         (40)         (48)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Fibrosis                                                      1 (2%)                                                          
      Pars Distalis, Cyst                              1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (58)         (50)         (50)         (60)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
      Follicular Cell, Cyst                            1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Follicular Cell, Hyperplasia                     2 (3%)       6 (12%)      3 (6%)       2 (3%)                                
      Follicular Cell, Hyperplasia, Papillary                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                    (1)                                    
      Mediastinum, Inflammation, Suppurative           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (50)         (50)         (59)                                   
      Granuloma                                                     1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Preputial Gland                                    (16)         (21)         (13)         (9)                                    
      Hyperplasia                                      1 (6%)                                                                       
      Inflammation, Suppurative                        1 (6%)       1 (5%)       1 (8%)                                             
      Duct, Dilatation                                14 (88%)     19 (90%)     12 (92%)      7 (78%)                               
   Prostate                                           (59)         (50)         (50)         (60)                                   
      Infiltration Cellular, Lymphocyte                2 (3%)                    1 (2%)       3 (5%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
   Seminal Vesicle                                    (59)         (50)         (50)         (60)                                   
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Testes                                             (59)         (50)         (50)         (59)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (50)         (59)                                   
      Hyperplasia, Neutrophil                                                    1 (2%)                                             
   Lymph Node                                         (59)         (50)         (49)         (60)                                   
      Deep Cervical, Hyperplasia, Plasma Cell          1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
   Lymph Node, Mandibular                             (57)         (48)         (48)         (54)                                   
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (59)         (49)         (47)         (56)                                   
      Congestion                                       2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            5 (8%)                    2 (4%)       2 (4%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Inflammation, Suppurative                        2 (3%)                                                                       
   Spleen                                             (59)         (50)         (51)         (59)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       1 (2%)       1 (2%)                                                          
      Developmental Malformation                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation Erythrocytic    4 (7%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            4 (7%)       1 (2%)       3 (6%)       2 (3%)                                
      Lymphocyte, Atrophy                                           1 (2%)                                                          
   Thymus                                             (57)         (45)         (44)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (51)         (51)         (60)                                   
      Alopecia                                         3 (5%)       5 (10%)      2 (4%)       1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (50)         (50)         (60)                                   
      Metacarpal, Inflammation, Chronic                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (50)         (50)         (59)                                   
      Meninges, Fibrosis                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (51)         (60)                                   
      Congestion                                                                              2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 3 (5%)       1 (2%)       4 (8%)       5 (8%)                                
      Alveolus, Hemorrhage                                                       2 (4%)                                             
      Bronchiole, Dilatation, Focal                                              1 (2%)                                             
      Bronchiole, Epithelium, Hyperplasia                           2 (4%)                    1 (2%)                                
      Bronchiole, Epithelium, Necrosis                                                        2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05090-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Pleura, Inflammation, Suppurative                                          1 (2%)                                             
   Nose                                               (59)         (50)         (50)         (60)                                   
      Fungus                                                                                  1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Lumen, Inflammation, Suppurative                                                        4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)                       (1)          (1)                                    
      Inflammation, Chronic, Diffuse                                                          1 (100%)                              
      Retrobulbar, Infiltration Cellular, Focal,                                                                                    
           Lymphocyte                                  1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (50)         (50)         (58)                                   
      Ectopic Tissue                                   1 (2%)                                                                       
      Fibrosis                                                                                1 (2%)                                
      Glomerulosclerosis                               1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                5 (8%)       4 (8%)       4 (8%)       5 (9%)                                
      Nephropathy                                      8 (14%)     12 (24%)      8 (16%)      3 (5%)                                
      Collecting Tubule, Necrosis, Coagulative                                   1 (2%)       1 (2%)                                
      Cortex, Cyst                                     1 (2%)                    4 (8%)                                             
      Cortex, Cyst Multilocular                        1 (2%)       1 (2%)       1 (2%)                                             
      Glomerulus, Inflammation, Chronic                                                       1 (2%)                                
      Pelvis, Infiltration Cellular, Lymphocyte        5 (8%)                                 2 (3%)                                
      Renal Tubule, Mineralization                     1 (2%)                                                                       
      Renal Tubule, Necrosis, Coagulative              1 (2%)       2 (4%)       3 (6%)                                             
      Renal Tubule, Pigmentation, Hemosiderin                       1 (2%)                                                          
   Urethra                                                                                   (1)                                    
      Inflammation, Chronic Active                                                            1 (100%)                              
   Urinary Bladder                                    (59)         (50)         (50)         (57)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Infiltration Cellular, Lymphocyte                4 (7%)       2 (4%)       4 (8%)       9 (16%)                               
      Inflammation, Chronic                            1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------