TDMS Study 05090-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
COUMARIN
NTP Experiment-Test: 05090-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/12/94
Route: GAVAGE Time: 06:23:07
Facility: American Biogenics Corp.
Chemical CAS #: 91-64-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 18 20 19 19
Early Deaths
Dead 7 5 3 13
Moribund 8 5 5 8
Gavage Death 4 1 2
Survivors
Terminal Sacrifice 33 39 42 28
Moribund 1
Animals Examined Microscopically 60 58 58 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (44) (47) (48)
Intestine Large, Cecum (50) (46) (48) (50)
Intestine Small (52) (46) (48) (50)
Intestine Small, Ileum (49) (46) (48) (48)
Intestine Small, Jejunum (49) (46) (48) (50)
Sarcoma 1 (2%)
Liver (58) (50) (53) (59)
Alveolar/Bronchiolar Carcinoma, Metastatic 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 3 (6%) 3 (6%) 1 (2%)
Hepatocellular Adenoma 9 (16%) 18 (36%) 20 (38%) 10 (17%)
Hepatocellular Adenoma, Multiple 8 (16%) 9 (17%) 2 (3%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (7) (6) (3) (4)
Histiocytic Sarcoma 1 (17%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (33%)
Pancreas (56) (48) (48) (54)
Salivary Glands (59) (50) (51) (60)
Leiomyosarcoma, Metastatic 1 (2%)
Stomach, Forestomach (56) (50) (50) (55)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 5 (10%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (50) (51) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (57) (47) (48) (60)
Spindle Cell, Adenoma 1 (2%)
Adrenal Gland, Cortex (57) (47) (47) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic 1 (2%)
Spindle Cell, Adenoma 1 (2%)
Adrenal Gland, Medulla (57) (47) (48) (59)
Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (57) (48) (48) (56)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (53) (45) (45) (57)
Neoplasm NOS 1 (2%)
Pars Distalis, Adenoma 4 (8%) 3 (7%) 4 (9%)
Thyroid Gland (55) (49) (50) (56)
Bilateral, Follicular Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1)
Posterior, Fibrosarcoma 1 (100%)
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GENITAL SYSTEM
Ovary (59) (52) (52) (60)
Cystadenoma 2 (3%) 3 (6%) 4 (8%) 2 (3%)
Histiocytic Sarcoma 1 (2%)
Uterus (58) (55) (51) (60)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp 1 (2%)
Sarcoma 1 (2%)
Sarcoma Stromal 2 (3%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (48) (49) (60)
Lymph Node (57) (49) (49) (59)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (55) (47) (49) (53)
Lymph Node, Mesenteric (53) (45) (48) (56)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Spleen (58) (48) (48) (57)
Thymus (51) (44) (49) (51)
Alveolar/Bronchiolar Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (59) (51) (56) (60)
Fibroma 1 (2%)
Fibrosarcoma 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Subcutaneous Tissue, Leiomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (50) (51) (60)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (2) (1)
Leiomyosarcoma, Metastatic 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (49) (50) (58)
Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (50) (50) (60)
Alveolar/Bronchiolar Adenoma 2 (3%) 5 (10%) 8 (16%) 17 (28%)
Alveolar/Bronchiolar Adenoma, Multiple 5 (8%)
Alveolar/Bronchiolar Carcinoma 7 (12%)
Nose (58) (50) (51) (59)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1) (1) (1)
Adenoma 1 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (47) (49) (58)
Urinary Bladder (53) (47) (48) (56)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(58) *(58) *(60)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant 4 (7%) 2 (3%) 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 6 (10%) 6 (10%) 4 (7%)
Lymphoma Malignant Mixed 3 (5%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 26 41 37 36
Total Primary Neoplasms 34 69 66 58
Total Animals with Benign Neoplasms 21 33 34 28
Total Benign Neoplasms 24 47 51 41
Total Animals with Malignant Neoplasms 8 19 13 14
Total Malignant Neoplasms 10 22 14 17
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 2 2 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 20 19
Early Deaths
Dead 5 3 1 11
Moribund 1 6 3
Gavage Death 1 1
Survivors
Terminal Sacrifice 43 47 42 37
Animals Examined Microscopically 60 58 57 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (47) (47) (48)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Intestine Large, Cecum (57) (47) (49) (51)
Intestine Small, Ileum (58) (47) (49) (51)
Intestine Small, Jejunum (56) (47) (50) (51)
Adenocarcinoma 2 (4%) 1 (2%)
Adenoma 1 (2%)
Liver (60) (54) (56) (60)
Hepatoblastoma 5 (9%) 1 (2%)
Hepatocellular Carcinoma 10 (17%) 11 (20%) 5 (9%) 3 (5%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 15 (25%) 11 (20%) 12 (21%) 16 (27%)
Hepatocellular Adenoma, Multiple 11 (18%) 20 (37%) 18 (32%) 14 (23%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Mesentery (8) (3) (3) (3)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (33%)
Pancreas (59) (50) (50) (59)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Stomach, Forestomach (58) (49) (50) (56)
Squamous Cell Carcinoma 1 (2%) 2 (4%)
Squamous Cell Papilloma 2 (3%) 8 (16%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (49) (49) (59)
Adenoma 1 (2%)
Adrenal Gland, Medulla (59) (49) (48) (58)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (59) (50) (50) (59)
Adenoma 3 (6%) 2 (3%)
Thyroid Gland (58) (50) (50) (60)
C-Cell, Adenoma 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (50) (50) (59)
Preputial Gland (16) (21) (13) (9)
Prostate (59) (50) (50) (60)
Seminal Vesicle (59) (50) (50) (60)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Testes (59) (50) (50) (59)
Interstitial Cell, Adenoma 3 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (50) (50) (59)
Lymph Node (59) (50) (49) (60)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (57) (48) (48) (54)
Lymph Node, Mesenteric (59) (49) (47) (56)
Spleen (59) (50) (51) (59)
Histiocytic Sarcoma 1 (2%)
Thymus (57) (45) (44) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (59) (51) (51) (60)
Basal Cell Adenoma 1 (2%)
Tail, Neurofibroma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (50) (50) (60)
Skeletal Muscle (1)
Diaphragm, Squamous Cell Carcinoma,
Metastatic, Stomach 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (50) (50) (59)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (52) (51) (60)
Alveolar/Bronchiolar Adenoma 12 (20%) 10 (19%) 12 (24%) 22 (37%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (3%) 2 (4%) 5 (8%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Carcinoma, Metastatic 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic,
Metastatic 1 (2%)
Nose (59) (50) (50) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (1) (1) (1)
Adenoma 3 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (50) (50) (58)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (59) (50) (50) (57)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(58) *(57) *(60)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 2 (4%) 1 (2%)
Lymphoma Malignant Histiocytic 2 (3%)
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(60) *(58) *(57) *(60)
Lymphoma Malignant Lymphocytic 3 (5%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 43 43 45
Total Primary Neoplasms 64 72 69 72
Total Animals with Benign Neoplasms 38 38 37 44
Total Benign Neoplasms 50 54 51 63
Total Animals with Malignant Neoplasms 14 14 16 8
Total Malignant Neoplasms 14 18 18 9
Total Animals with Metastatic Neoplasms 2 1 2 1
Total Metastatic Neoplasm 2 1 8 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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