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TDMS Study 05090-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              COUMARIN


NTP Experiment-Test: 05090-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 06:23:07




       Facility:  American Biogenics Corp.

       Chemical CAS #:  91-64-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 18           20           19           19                                     
  Early Deaths                                                                                                                      
    Dead                                               7            5            3           13                                     
    Moribund                                           8            5            5            8                                     
    Gavage Death                                       4                         1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           39           42           28                                     
    Moribund                                                        1                                                               
  Animals Examined Microscopically                    60           58           58           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (44)         (47)         (48)                                   
   Intestine Large, Cecum                             (50)         (46)         (48)         (50)                                   
   Intestine Small                                    (52)         (46)         (48)         (50)                                   
   Intestine Small, Ileum                             (49)         (46)         (48)         (48)                                   
   Intestine Small, Jejunum                           (49)         (46)         (48)         (50)                                   
      Sarcoma                                                                                 1 (2%)                                
   Liver                                              (58)         (50)         (53)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic                                              1 (2%)                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                                      3 (6%)       3 (6%)       1 (2%)                                
      Hepatocellular Adenoma                           9 (16%)     18 (36%)     20 (38%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                              8 (16%)      9 (17%)      2 (3%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Mesentery                                          (7)          (6)          (3)          (4)                                    
      Histiocytic Sarcoma                                           1 (17%)                                                         
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (33%)                                            
   Pancreas                                           (56)         (48)         (48)         (54)                                   
   Salivary Glands                                    (59)         (50)         (51)         (60)                                   
      Leiomyosarcoma, Metastatic                       1 (2%)                                                                       
   Stomach, Forestomach                               (56)         (50)         (50)         (55)                                   
      Squamous Cell Carcinoma                                       1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       5 (10%)      2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (50)         (51)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (57)         (47)         (48)         (60)                                   
      Spindle Cell, Adenoma                                                                   1 (2%)                                
   Adrenal Gland, Cortex                              (57)         (47)         (47)         (60)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic                                              1 (2%)                                
      Spindle Cell, Adenoma                                         1 (2%)                                                          
   Adrenal Gland, Medulla                             (57)         (47)         (48)         (59)                                   
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (57)         (48)         (48)         (56)                                   
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (53)         (45)         (45)         (57)                                   
      Neoplasm NOS                                                               1 (2%)                                             
      Pars Distalis, Adenoma                           4 (8%)       3 (7%)       4 (9%)                                             
   Thyroid Gland                                      (55)         (49)         (50)         (56)                                   
      Bilateral, Follicular Cell, Carcinoma            1 (2%)                                                                       
      Follicular Cell, Adenoma                                                   1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (2)          (1)                                                 
      Posterior, Fibrosarcoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (52)         (52)         (60)                                   
      Cystadenoma                                      2 (3%)       3 (6%)       4 (8%)       2 (3%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Uterus                                             (58)         (55)         (51)         (60)                                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp                                                         1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma Stromal                                                                         2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (48)         (49)         (60)                                   
   Lymph Node                                         (57)         (49)         (49)         (59)                                   
      Mediastinal, Histiocytic Sarcoma                              1 (2%)                                                          
   Lymph Node, Mandibular                             (55)         (47)         (49)         (53)                                   
   Lymph Node, Mesenteric                             (53)         (45)         (48)         (56)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Spleen                                             (58)         (48)         (48)         (57)                                   
   Thymus                                             (51)         (44)         (49)         (51)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (51)         (56)         (60)                                   
      Fibroma                                          1 (2%)                                                                       
      Fibrosarcoma                                     1 (2%)       1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Subcutaneous Tissue, Leiomyosarcoma              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (51)         (60)                                   
      Vertebra, Osteosarcoma                                        1 (2%)                                                          
   Skeletal Muscle                                    (2)                       (1)                                                 
      Leiomyosarcoma, Metastatic                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (49)         (50)         (58)                                   
      Meningioma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (50)         (50)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       5 (10%)      8 (16%)     17 (28%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                                  5 (8%)                                
      Alveolar/Bronchiolar Carcinoma                                                          7 (12%)                               
   Nose                                               (58)         (50)         (51)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)          (1)          (1)                                    
      Adenoma                                          1 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (47)         (49)         (58)                                   
   Urinary Bladder                                    (53)         (47)         (48)         (56)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(58)        *(58)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Lymphoma Malignant                               4 (7%)       2 (3%)       1 (2%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Lymphocytic                                6 (10%)      6 (10%)      4 (7%)                                
      Lymphoma Malignant Mixed                                      3 (5%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            26          41          37          36                                       
     Total Primary Neoplasms                           34          69          66          58                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          33          34          28                                       
     Total Benign Neoplasms                            24          47          51          41                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               8          19          13          14                                       
     Total Malignant Neoplasms                         10          22          14          17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1           1                                       
     Total Metastatic Neoplasm                          2                       2           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           19                                     
  Early Deaths                                                                                                                      
    Dead                                               5            3            1           11                                     
    Moribund                                           1                         6            3                                     
    Gavage Death                                       1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           47           42           37                                     
  Animals Examined Microscopically                    60           58           57           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (50)         (47)         (47)         (48)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Intestine Large, Cecum                             (57)         (47)         (49)         (51)                                   
   Intestine Small, Ileum                             (58)         (47)         (49)         (51)                                   
   Intestine Small, Jejunum                           (56)         (47)         (50)         (51)                                   
      Adenocarcinoma                                   2 (4%)       1 (2%)                                                          
      Adenoma                                                       1 (2%)                                                          
   Liver                                              (60)         (54)         (56)         (60)                                   
      Hepatoblastoma                                                             5 (9%)       1 (2%)                                
      Hepatocellular Carcinoma                        10 (17%)     11 (20%)      5 (9%)       3 (5%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          15 (25%)     11 (20%)     12 (21%)     16 (27%)                               
      Hepatocellular Adenoma, Multiple                11 (18%)     20 (37%)     18 (32%)     14 (23%)                               
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Mesentery                                          (8)          (3)          (3)          (3)                                    
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (33%)                                            
   Pancreas                                           (59)         (50)         (50)         (59)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Stomach, Forestomach                               (58)         (49)         (50)         (56)                                   
      Squamous Cell Carcinoma                                       1 (2%)       2 (4%)                                             
      Squamous Cell Papilloma                          2 (3%)       8 (16%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (49)         (49)         (59)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (59)         (49)         (48)         (58)                                   
      Pheochromocytoma Benign                          1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (59)         (50)         (50)         (59)                                   
      Adenoma                                                                    3 (6%)       2 (3%)                                
   Thyroid Gland                                      (58)         (50)         (50)         (60)                                   
      C-Cell, Adenoma                                               1 (2%)                                                          
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                                                2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (50)         (50)         (59)                                   
   Preputial Gland                                    (16)         (21)         (13)         (9)                                    
   Prostate                                           (59)         (50)         (50)         (60)                                   
   Seminal Vesicle                                    (59)         (50)         (50)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Testes                                             (59)         (50)         (50)         (59)                                   
      Interstitial Cell, Adenoma                       3 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (50)         (59)                                   
   Lymph Node                                         (59)         (50)         (49)         (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node, Mandibular                             (57)         (48)         (48)         (54)                                   
   Lymph Node, Mesenteric                             (59)         (49)         (47)         (56)                                   
   Spleen                                             (59)         (50)         (51)         (59)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (57)         (45)         (44)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (51)         (51)         (60)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Tail, Neurofibroma                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (50)         (50)         (60)                                   
   Skeletal Muscle                                                              (1)                                                 
      Diaphragm, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Stomach                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (50)         (50)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (51)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    12 (20%)     10 (19%)     12 (24%)     22 (37%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)                    2 (4%)       5 (8%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic             1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic,                                                                                         
          Metastatic                                                                          1 (2%)                                
   Nose                                               (59)         (50)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (1)          (1)          (1)                                    
      Adenoma                                          3 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (50)         (50)         (58)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (59)         (50)         (50)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(58)        *(57)        *(60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Lymphoma Malignant                                                         2 (4%)       1 (2%)                                
      Lymphoma Malignant Histiocytic                                                          2 (3%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(60)        *(58)        *(57)        *(60)                                   
      Lymphoma Malignant Lymphocytic                                3 (5%)       1 (2%)                                             
      Lymphoma Malignant Mixed                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05090-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 06:23:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG     200MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          43          43          45                                       
     Total Primary Neoplasms                           64          72          69          72                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          38          37          44                                       
     Total Benign Neoplasms                            50          54          51          63                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          14          16           8                                       
     Total Malignant Neoplasms                         14          18          18           9                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           2           1                                       
     Total Metastatic Neoplasm                          2           1           8           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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