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TDMS Study 05090-02 Pathology Tables

NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97
Route: GAVAGE                                                                                                     Time: 12:04:13




       Facility:  American Biogenics Corp.

       Chemical CAS #:  91-64-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  M  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  M     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +     +  M  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                                2         |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                        2                                 |             
      Infiltration Cellular, Lymphocyte    |                                                       1              2   |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |             4                                   1                        |             
      Pigmentation                         |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                          +  +         |             
      Cyst                                 |                                                                          |             
      Fat, Necrosis, Coagulative           |                            2     2                          3  3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Atrophy                              |                                                             2            |             
      Fibrosis                             |                2                                                         |             
      Infiltration Cellular, Lymphocyte    | 2  2        2     2     2                                            2   |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                          1        2              2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Spindle Cell, Hyperplasia            | 2  2        3  2  1  2  2           2  3  2  2        2     2  1        3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  I  M  +  +     M  M  M  M  +  +     +     +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +     +  +  +  M  +  +     +     +  M  A  +  +|             
      Pars Distalis, Cyst                  |                         3                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     I  +  +  +  +  +     +     +  +  A  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Hematocyst                           |                            4                                             |             
      Inflammation, Suppurative            |                                           4                              |             
      Follicle, Cyst                       | 4           4     3              4              4              2  4     4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Hydrometra                           | 2           3              4        3        3                           |             
      Hyperplasia, Cystic                  |    2           3  3  2  3        2     2        2     2     2  3     2  4|             
      Inflammation, Suppurative            |                                        3  3                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 +                        |             
      Hyperkeratosis                       |                                                 3                        |             
      Inflammation, Suppurative            |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                                 4                        |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Angiectasis                          |                   3                                                      |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                   3                       3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +     +  M  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Hyperkeratosis                       |                                                       2                  |             
      Foot, Inflammation, Suppurative      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                       +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
      Hypothalamus, Compression            |          X                                                               |             
      Thalamus, Compression                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Foreign Body                         |                                                                          |             
      Hyperplasia, Histiocytic             |                                              1                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Mediastinum, Foreign Body            |                                                                          |             
      Peribronchiolar, Hemorrhage          |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Cataract                             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Glomerulosclerosis                   |                                  2                                       |             
      Infiltration Cellular, Lymphocyte    |          2                       2                          1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Collecting Tubule, Pigmentation,     |                                                                          |             
           Hemoglobin                      |                                                 3                        |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +     +     +  +  A  M  +|             
      Infiltration Cellular, Lymphocyte    | 1  1        2     3        2     2        1  1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  M  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  +  +  M  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A  +  +  M  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A  +  +  I  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                        2                                 |             
      Cytoplasmic Alteration               |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                     3                                    |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2     2  2                                                  2   |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |                                                                      2   |             
      Pigmentation                         |             2                                                            |             
      Centrilobular, Necrosis              |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Cyst                                 |                                                                          |             
      Fat, Necrosis, Coagulative           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Atrophy                              |             3                                                            |             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
      Necrosis, Coagulative                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2     2  2                             2                    2   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Spindle Cell, Hyperplasia            |       2  2        2                 2  2  3  1        2  2  2     2  3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  M  +  +        M  M     +  +  M  +  M     +  M  +     M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Pars Distalis, Cyst                  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +        M  +     +  +  +  +  +     +  +  +     +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Hematocyst                           |                                     4                                    |             
      Inflammation, Suppurative            |                                                                      4   |             
      Follicle, Cyst                       |                   4                             3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Hydrometra                           |          4                                                               |             
      Hyperplasia, Cystic                  |                3  2                 2  2  4  3  2     2           2     2|             
      Inflammation, Suppurative            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M  +  +  +  +  +        +  M     +  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  M  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                 2                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                               3                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +        +  +     +  +  +  +  I     +  +  +     +  +  +|             
      Atrophy                              |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  M        M  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Alopecia                             |                                              3                    2      |             
      Hyperkeratosis                       |                                                                          |             
      Foot, Inflammation, Suppurative      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
      Thalamus, Compression                |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Congestion                           |    3                                                                     |             
      Foreign Body                         |                            2                                             |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
      Inflammation, Suppurative            |                            3                                             |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Mediastinum, Foreign Body            |                                                                          |             
      Peribronchiolar, Hemorrhage          |    3                                                                     |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    A  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Glomerulosclerosis                   |                               4                                          |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Collecting Tubule, Pigmentation,     |                                                                          |             
           Hemoglobin                      |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |       2                                               1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2        2                    1     1  2        2     2        2  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +     +  +  +  +  +  A  +  A  A  +  +  +  M  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +     A  +  +  +  +  A  +  A  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +     A  +  +  +  +  +  +  A  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  M     A  +  +  +  M  +  +  A  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +     A  +  +  +  +  +  +  A  A  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +     A  +  +  +  +  +  +  A  A  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +     A  +  +  +  +  A  +  M  M  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +     A  +  +  +  +  A  +  A  A     +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Angiectasis                          |             2                                                            |      1  2.0|
      Basophilic Focus                     |       1                                                                  |      2  1.5|
      Cytoplasmic Alteration               |       1                                                                  |      1  1.0|
      Developmental Malformation           |                                                          X               |      1     |
      Eosinophilic Focus                   |                      2                                   3               |      4  2.5|
      Hemorrhage                           | 1                                                                        |      1  1.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                       1  2               |      8  1.8|
      Inflammation, Chronic                |                                              2                           |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      3  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                       +                                                |   7        |
      Cyst                                 |                         4                                                |      1  4.0|
      Fat, Necrosis, Coagulative           |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +     +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  56        |
      Atrophy                              |                                                                          |      2  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |       1                    2                 2                           |     10  1.9|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    | 2     1     2        1  2  2  1     2        2  2  1     1               |     22  1.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  54        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  57        |
      Spindle Cell, Hyperplasia            | 2  2  2     2        1  2  2  2     2  2     2  3  2     3               |     42  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  57        |
      Vacuolization Cytoplasmic            |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  57        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +     +  +  +  +  +  +  +  M  +  +  +  M  +  +               |  40        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  I               |  53        |
      Pars Distalis, Cyst                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  55        |
      Follicular Cell, Hyperplasia         |                         2           2                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hematocyst                           |                                                                          |      2  4.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Follicle, Cyst                       | 4  3                                4                                    |     13  3.6|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  A  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Hydrometra                           |    4                             2  4                    3               |     10  3.2|
      Hyperplasia, Cystic                  |       2     4        2     3           2     2     2  3                  |     31  2.5|
      Inflammation, Suppurative            |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +     +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  57        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +     +  +  +  +  +  +  +  A  M  +  +  +  +  +               |  55        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +     +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                         1                                                |      1  1.0|
      Hyperplasia, Lymphoid                |                                     2  2              2                  |      4  2.3|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  A  +     +  +  +  +  +  +  +  A  A  I  +  +  M  +               |  51        |
      Atrophy                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  A  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Alopecia                             |                      1  2                          3                     |      5  2.2|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Foot, Inflammation, Suppurative      |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  57        |
      Hypothalamus, Compression            |                                                                          |      1     |
      Thalamus, Compression                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Congestion                           |                                                                          |      2  3.0|
      Foreign Body                         |                                  2        2                              |      3  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                | 2                    1                                                   |      3  1.7|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolus, Hemorrhage                 |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Foreign Body            |                                  4                                       |      1  4.0|
      Peribronchiolar, Hemorrhage          |                                                                          |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Glomerulosclerosis                   |                                                                          |      2  3.0|
      Infiltration Cellular, Lymphocyte    | 2                             3              1           1               |      8  1.8|
      Artery, Necrosis, Fibrinoid          |                               2                                          |      1  2.0|
      Collecting Tubule, Pigmentation,     |                                                                          |            |
           Hemoglobin                      |                                                                          |      1  3.0|
      Pelvis, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                    2                     |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  53        |
      Infiltration Cellular, Lymphocyte    | 3  2                 3  2  4  2     1        2        2  2               |     27  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +     +        M        I  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  I     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |    1     4                 2        1                 2     3     2      |             
      Fatty Change                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                       2                  |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |    1                                                                     |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                | 4                                            2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +        +              +         |             
      Fat, Necrosis, Coagulative           |                                        4        4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Atrophy                              | 3                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                                    2     2               |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |             2              3        3              1     2  1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Hyperkeratosis                       |                   2                                                      |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Ulcer                                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Mineralization                       | 2                                                                        |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Corticomedullary Junction, Hemorrhage|                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Corticomedullary Junction, Necrosis, |                                                                          |             
           Coagulative                     |                                                                          |             
      Spindle Cell, Hyperplasia            |                   1                    2  1        2  2              2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Necrosis, Coagulative                |                                                                          |             
      Corticomedullary Junction, Necrosis, |                                                                          |             
           Coagulative                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Atrophy                              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +        +        +  +  +  M  +  +  M  +  +  M     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     M        +        +  +  +  +  M  +  +  +  +  +     M   |             
      Pars Distalis, Hyperplasia           |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Inflammation, Suppurative            |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |             3                                                            |             
      Follicular Cell, Hyperplasia         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Hemorrhage                           |                                                                          |             
      Abdominal, Necrosis, Coagulative     |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +        +  +     +  +  +  +  +  +  +  +  +  +     +   |             
      Hematocyst                           |                                                             3            |             
      Inflammation, Suppurative            |                               3                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Follicle, Cyst                       | 3        2  3                             3  2  3        3           3   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hydrometra                           |    4                       3                                             |             
      Hyperplasia, Cystic                  | 2        3        4     2        3  3  2  3           3  3  2        3   |             
      Inflammation, Suppurative            |          2  4                                3                    4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  I  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Plasma Cell             |                                                    2                     |             
      Inflammation, Suppurative            | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                    2                 3   |             
      Hyperplasia, Lymphoid                |                                     2                 3  3  3            |             
      Hyperplasia, Plasma Cell             |       3                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Duct, Dilatation                     |                                              3                           |             
      Duct, Hyperplasia                    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +        +  +  +  +  +  +  +  +  +  +     +   |             
      Alopecia                             |                         2                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                2  1      |             
      Alveolus, Hemorrhage                 |                                                             2            |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulosclerosis                   | 3                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                                    2     2               |             
      Cortex, Pigmentation, Bile           |                                                                      2   |             
      Renal Tubule, Degeneration           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M     +        +        +  M  +  +  +  +  +  +  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |          1        1        2        2     2  1     2  3  3           1   |             
      Inflammation, Suppurative            |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  M  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  A  A  +  +  +  +              +  +  M  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      3                                                   |             
      Eosinophilic Focus                   |    1                                      2           2  2  3  3     2  2|             
      Fatty Change                         |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                                                                         1|             
      Mixed Cell Focus                     |                2                                                         |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2              1                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |             +                                                            |             
      Cyst                                 |             4                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2              1                                         2  1  1      |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +              +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +              +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                   2                       4                              |             
      Hyperplasia, Squamous                |                                           3                              |             
      Inflammation, Suppurative            |                                        2                 2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  M  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Corticomedullary Junction, Hemorrhage|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Corticomedullary Junction, Necrosis, |                                                                          |             
           Coagulative                     |                                                                          |             
      Spindle Cell, Hyperplasia            |                   2                       2              1     2  1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
      Corticomedullary Junction, Necrosis, |                                                                          |             
           Coagulative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  M  +  +  +  +              +  +  M  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      C-Cell, Hyperplasia                  |                                                 2                        |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Abdominal, Necrosis, Coagulative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  A  +  +  +  +  +        +     +  +  +  +     +  +  +  +  +  +  +|             
      Hematocyst                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Follicle, Cyst                       |                   3     3        3     3                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  A  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hydrometra                           |                                  4           3           4     3         |             
      Hyperplasia, Cystic                  |    2  3           3  3              3  4  3     2     2           3  3   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  M  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M  M  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  M  M  +  +  +  +              +  +  M  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  A  A  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Developmental Malformation           |                      X                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Suppurative            |                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  A  M  M  +  +  +              +  +  +  +     +  +  +  +  +  +  I|             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  M  +  +  +  +              +  +  +  +     +  +  +  +  +  +  M|             
      Duct, Dilatation                     |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  A  +  +  +  +        +     +  +  +  +     +  +  +  +  +  +  +|             
      Alopecia                             |                3                 2              1                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         2                                                |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
      Cortex, Pigmentation, Bile           |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                      1            |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                2              3  2  2  3                 3               |     21  2.2|
      Fatty Change                         |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
      Inflammation, Necrotizing            |                                        2                                 |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                                         |   6        |
      Fat, Necrosis, Coagulative           |                3                                                         |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Atrophy                              |       4                                                                  |      2  3.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Infiltration Cellular, Lymphocyte    |                      1           1                       1               |     14  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Hyperkeratosis                       |                                  2                                       |      4  2.5|
      Hyperplasia, Squamous                |                                                          3               |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Perivascular, Inflammation, Chronic  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Corticomedullary Junction, Hemorrhage|                                                                          |      1  3.0|
      Corticomedullary Junction, Necrosis, |                                                                          |            |
           Coagulative                     |                                     2                                    |      1  2.0|
      Spindle Cell, Hyperplasia            | 2                                      2                                 |     13  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Necrosis, Coagulative                |                                     2                                    |      1  2.0|
      Corticomedullary Junction, Necrosis, |                                                                          |            |
           Coagulative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M     +  M  +  M  +  +  +  +  +  +                 M               |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  45        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
      C-Cell, Hyperplasia                  |                      2                                                   |      2  2.0|
      Follicle, Cyst                       |       2                                                                  |      1  2.0|
      Follicle, Dilatation                 |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |                                  3                       2               |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   2        |
      Hemorrhage                           |                                  3                                       |      1  3.0|
      Abdominal, Necrosis, Coagulative     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +     +  +  +  +  +  +  +  +  +  +              +  +               |  52        |
      Hematocyst                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                        4                                 |      2  3.5|
      Capsule, Inflammation, Chronic       |                                                       3                  |      1  3.0|
      Follicle, Cyst                       |       3                       4     3                 4                  |     16  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +     +  +  +  +  +  +  +  +  +  +              +  +               |  55        |
      Hydrometra                           |             3           4  3     4                                       |     10  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                               2     3  2                                 |     26  2.7|
      Inflammation, Suppurative            |                                                                          |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +     +  +  +  +  +  +  +  +  +  M                 +               |  47        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  45        |
      Hyperplasia, Lymphoid                |                         2        2                                       |      4  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Developmental Malformation           |             X                                                            |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.8|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  44        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Duct, Dilatation                     |                                                                          |      1  3.0|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  51        |
      Alopecia                             |                   1                                                      |      5  1.8|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Hyperplasia, Lymphoid                |                                  2                                       |      2  2.0|
      Alveolar Epithelium, Hyperplasia     | 3                                                                        |      4  2.0|
      Alveolus, Hemorrhage                 |                                                                          |      1  2.0|
      Bronchiole, Epithelium, Hyperplasia  |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                      2           2                                       |      5  2.0|
      Cortex, Pigmentation, Bile           |                                                                          |      1  2.0|
      Renal Tubule, Degeneration           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Infiltration Cellular, Lymphocyte    |                               2                          2               |     14  1.7|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +  +  +     +  +        M  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +  +     +  +  +     +  +  +  +  +     +  +  +  +        +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                         2|             
      Eosinophilic Focus                   |    2  2        2              1        2  1           2                 2|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                 2                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Syncytial Alteration                 |                                     1                                   1|             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Atrophy                              |                                                                         2|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2        3  2           3  2  1                           |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |             1     1        2        1        1              2            |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                            2           2                       3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Inflammation, Chronic Active         |                                                 3                        |             
      Nuclear Alteration                   |                                                                2         |             
      Artery, Inflammation, Chronic Active |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Corticomedullary Junction, Hemorrhage|                                                                          |             
      Spindle Cell, Hyperplasia            |       3        2  2     2  2           2     2        2  2     2        1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +  +  +     +  +        +  +  +  +  I     +  +  +  +        +|             
      Clear Cell Focus                     |                                                                          |             
      Cytoplasmic Alteration               |             3                                                            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     M  +  +     +  +        M  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +  +  +     +  +        +  M  +  +  +     +  +  M  M        +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Inflammation, Suppurative            |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |                                                                2         |             
      Follicular Cell, Hyperplasia         |                                     2                                   2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
      Posterior, Abscess                   |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hematocyst                           |                                                 4                        |             
      Pigmentation, Ceroid                 |                                                                          |             
      Follicle, Cyst                       | 3                                      3     3        4  3  3            |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +     +  +  +     +  +  +     +  +  +  +  +     +  +  +  +        +|             
      Hydrometra                           |                   3                                   3  4     3         |             
      Hyperplasia, Cystic                  |       2     3           3  3  3     3        3  2           3           3|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hyperplasia, Neutrophil              |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            2        3                                    |             
      Necrosis                             |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     +  +  +     I  +        +  +  +  +  +     +  +  +  +        +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +        +|             
      Alopecia                             | 2           2                 2                 2                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
      Subpleura, Mineralization            |                                                             4            |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lumen, Inflammation, Suppurative     |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |                            3           2  1  1                           |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |       2        2  2     2           2  1  2  2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +     M  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | 3                 2  3  1  3           2        4     3  3               |             
      Infarct                              |                   4                                                      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                2                                                         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                      3                                                   |             
      Syncytial Alteration                 |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Hyperplasia              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +        +                                                |             
      Fat, Necrosis, Coagulative           |                         3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                   3                                                      |             
      Infiltration Cellular, Lymphocyte    |                                                       1                  |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |    1                          1                 1           2        1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Hyperkeratosis                       |                         2                                                |             
      Hyperplasia, Squamous                |                            2                                2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Nuclear Alteration                   |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  M  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Corticomedullary Junction, Hemorrhage|    2                                                                     |             
      Spindle Cell, Hyperplasia            |                   2  1  1  2  1     1                                2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  M  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Clear Cell Focus                     |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  M  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     +  M  +  +  +  +  +  +     +  +     +  I  +  +  +  +  +     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  M  +  +  +  M     +  +     A  +  +  +  +  +  +     +   |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
      Inflammation, Suppurative            |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                      2   |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia         |    2                                2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Posterior, Abscess                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
      Hematocyst                           |                                                                          |             
      Pigmentation, Ceroid                 |                      2                                                   |             
      Follicle, Cyst                       |    2                                                     3               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  M  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
      Hydrometra                           |                                              4                           |             
      Hyperplasia, Cystic                  |    2              3  4  4  2  2     3           2     3  3  3  3         |             
      Inflammation, Suppurative            |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Hyperplasia, Neutrophil              |                3                                                         |             
      Myelofibrosis                        |                                                       1                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +     +  +     A  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +     +  +     M  +  +  +  +  +  +     +   |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 3        3               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     M  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                | 3              2        2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +  +     +  +     A  +  +  +  +  +  +     +   |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +   |             
      Alopecia                             |                                     3     2                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                            4                                             |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
      Alveolus, Hemorrhage                 |                               1                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Pleura, Inflammation, Suppurative    |          3                                                               |             
      Subpleura, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
      Lumen, Inflammation, Suppurative     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |                                                 3           2            |             
      Renal Tubule, Degeneration           |                                                                1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |    2           1  3  1        1                          2  2  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Hyperplasia, Lymphoid                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  53        |
      Angiectasis                          |                                                          3               |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Eosinophilic Focus                   | 3                    2        2              2     3                     |     22  2.3|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                1                                                         |      1  1.0|
      Inflammation, Suppurative            |                                                 2                        |      2  2.0|
      Mixed Cell Focus                     |                2                                                         |      1  2.0|
      Necrosis, Coagulative                |                1                                                         |      2  2.0|
      Syncytial Alteration                 |                                                                          |      2  1.0|
      Bile Duct, Cyst                      |    4                                                                     |      1  4.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   3        |
      Fat, Necrosis, Coagulative           |                                                          4               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                   2                                2                     |      9  2.0|
      Necrosis, Coagulative                |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
      Infiltration Cellular, Lymphocyte    |                   1  1                             2  1  1               |     16  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nuclear Alteration                   |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Corticomedullary Junction, Hemorrhage|                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |          2           2        2              2        2                  |     23  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  47        |
      Clear Cell Focus                     |                                                 3                        |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  3.0|
      Hyperplasia                          | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +     M     M  M  +  +     M        +  +  +  +  +  +  +               |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  45        |
      Pars Distalis, Hyperplasia           |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
      C-Cell, Hyperplasia                  |                               2                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Dilatation                 |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                         1                       2                        |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Posterior, Abscess                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +     +  +  +  +     +     +  +  +  +  +  +  +  +               |  52        |
      Hematocyst                           |                                                                          |      1  4.0|
      Pigmentation, Ceroid                 |                                                                          |      1  2.0|
      Follicle, Cyst                       | 2  3           3              4     4           3  3                     |     15  3.1|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  51        |
      Hydrometra                           |                         3                                                |      6  3.3|
      Hyperplasia, Cystic                  | 2        3     3  3  3        4  3        3  2  3  2  3  2               |     35  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |    3                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  49        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
      Myelofibrosis                        |                      3                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +  +     +        M  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  +  +     +        M  +  +  +  +  +  +               |  49        |
      Hyperplasia, Lymphoid                |    3                          2                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +     +        M  +  +  +  +  +  +               |  48        |
      Hyperplasia, Lymphoid                |    2              2     3                                                |      7  2.6|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Developmental Malformation           |          X                                                               |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                 2                        |      1  2.0|
      Hyperplasia, Lymphoid                |    3                 2                                                   |      6  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  49        |
      Atrophy                              |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  56        |
      Alopecia                             |                                              2                           |      7  2.1|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |
      Inflammation, Chronic Active         |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Lymphoid                |                      2                                                   |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                         1                 3                              |      4  1.8|
      Alveolus, Hemorrhage                 |                         1                                                |      2  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                 2                        |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                           2                              |      1  2.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Subpleura, Mineralization            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
      Lumen, Inflammation, Suppurative     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  49        |
      Infiltration Cellular, Lymphocyte    |                                              2           3               |      8  2.1|
      Renal Tubule, Degeneration           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +     M        +  +  +  +  +  +  +               |  48        |
      Infiltration Cellular, Lymphocyte    | 2              2  2  2                       2  2        2               |     23  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +  A     +  A     +  +     +  +  +  A        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  A  +  +  +  A     +  A     +  +     +  +  +  A        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  A     +  A     +  +     +  +  +  M        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     A|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Basophilic Focus                     |                                     4                                    |             
      Clear Cell Focus                     |                                     1                             1      |             
      Congestion                           |                                                                         4|             
      Eosinophilic Focus                   |                            2                                            2|             
      Fatty Change                         |                                                       2                  |             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
      Inflammation, Chronic                |                                     1                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |             2                                      2                     |             
      Necrosis, Coagulative                |          3           3                                                   |             
      Syncytial Alteration                 |                1  1  2                             1  2        2        1|             
      Vacuolization Cytoplasmic            |                1  2                    1                                 |             
      Centrilobular, Hypertrophy           | 1     1  1     2  2        1           2     1  1              1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                                             |             
      Fat, Necrosis, Coagulative           |                      4     2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     +|             
      Atrophy                              |                                     4                                    |             
      Infiltration Cellular, Lymphocyte    |                2           1        3           1                        |             
      Inflammation, Suppurative            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Infiltration Cellular, Lymphocyte    | 2                                   1  2        2  1              2     2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     A|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Mineralization                       |                                                                          |             
      Necrosis, Zenkers                    |             3                                                            |             
      Artery, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Spindle Cell, Hyperplasia            |       2        2  2        2           2        2              1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  M  +  +  +  +     +  M     M  M     +  +  +  M        M  +     +|             
      Ectopic Thymus                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +     +  +     M  +     +  +  +  +        +  +     +|             
      Pars Distalis, Cyst                  |                                                                         3|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        M  +     A|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Hematocyst                           |                                     3                                    |             
      Bilateral, Corpus Luteum, Cyst       |                                                                          |             
      Follicle, Cyst                       | 3                                                                        |             
      Follicle, Hematocyst                 |                                              3                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Hydrometra                           |                3                             3  3  3           4         |             
      Hyperplasia, Cystic                  |       3  2        2                 2  2                                 |             
      Inflammation, Suppurative            | 2                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     M  +  +  +  M  +     +  M     +  +     +  +  +  +        M  +     +|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  M     +  A     +  +     +  +  +  +        +  +     +|             
      Amyloid Deposition                   |                                        2                                 |             
      Hyperplasia, Histiocytic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        M  +     +|             
      Atrophy                              |          3                                            3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis, Coagulative                |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Alopecia                             | 2                                      2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     A|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
      Alveolus, Hemorrhage                 |                                                    3                     |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                 2                        |             
      Bronchiole, Epithelium, Necrosis     |                                                    1                     |             
      Peribronchial, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  A        +  +     +|             
      Lumen, Inflammation, Suppurative     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        M  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                     2              1              1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          |                                                                          |             
      Collecting Tubule, Mineralization    |                                              3                           |             
      Collecting Tubule, Necrosis,         |                                                                          |             
          Coagulative                      |                                              2                           |             
      Cortex, Cyst Multilocular            |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                   2                    2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +     +  +     M  +     +  +  +  A        +  +     +|             
      Infiltration Cellular, Lymphocyte    |       2     1  2                       2        1  3           2  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +  +  +  +  A  +  A     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  A  A  +     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  A  A  A     +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  A  A  +     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  A  A  +     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  A  A  +     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  A  A  A     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  A  A  A     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  A  M  +     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         2                                         2      |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                               3              3                           |             
      Eosinophilic Focus                   |                                     1                    2           2  1|             
      Fatty Change                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                1                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                          1               |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |    4                          4     3     2                 3            |             
      Syncytial Alteration                 |    1  2           1        1        2     2  1        1  1        1  2   |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Centrilobular, Hypertrophy           |                1        1  1                       2     2        1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2                                         2               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                1     2     1        3        2     1     2     1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  A  +  A     A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  A  +  A     A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  A  A  A     A  A  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                                             |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis, Zenkers                    |                                                                          |             
      Artery, Mineralization               |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Hyperplasia            | 2     1        2  1  2              2           2  2                    2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +|             
      Ectopic Thymus                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                3         |             
      Follicular Cell, Hyperplasia         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hematocyst                           |                                                                      X   |             
      Bilateral, Corpus Luteum, Cyst       |                                                                          |             
      Follicle, Cyst                       | 3                       4                                                |             
      Follicle, Hematocyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                           3     2  3  4                 4|             
      Hyperplasia, Cystic                  | 3     3     2  3  3  2  4  3  4     2                          3  2  2  2|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Histiocytic             |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                     3                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     M  M  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Necrosis, Coagulative                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Alveolar Epithelium, Hyperplasia     |                            2                                   2         |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Bronchiole, Inflammation, Suppurative|    2                                                                     |             
      Bronchiole, Epithelium, Hyperplasia  |                            2  3                 2                        |             
      Bronchiole, Epithelium, Necrosis     |                                                                          |             
      Peribronchial, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Inflammation, Suppurative     |                               2                    2                 2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                    2     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          |                                                          2               |             
      Collecting Tubule, Mineralization    |                                                                          |             
      Collecting Tubule, Necrosis,         |                                                                          |             
          Coagulative                      |                                                                          |             
      Cortex, Cyst Multilocular            |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  A  +  +     A  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                          1        2        2     2  2  3     1  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +  A  M  A  +  A  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Lymphoid                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  M  +  A  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Basophilic Focus                     |       2                                                                  |      4  2.5|
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Congestion                           |                                                                          |      3  3.3|
      Eosinophilic Focus                   |    2                                      2        3                     |      9  1.9|
      Fatty Change                         |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                   2                                                      |      3  1.7|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       |                                  2                                       |      3  2.0|
      Necrosis, Coagulative                | 4           4                 3  3                                       |     11  3.3|
      Syncytial Alteration                 |    1     1                       2     1              1                  |     23  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      3  1.3|
      Centrilobular, Hypertrophy           |    1  1           2     1           1  2  1     2     1                  |     25  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +              +               |   4        |
      Fat, Necrosis, Coagulative           |                                           3              3               |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +               |  54        |
      Atrophy                              |       1                                                                  |      2  2.5|
      Infiltration Cellular, Lymphocyte    |       2  2                          2  2                                 |     10  1.9|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |    1     2  1     2     1                 2  1  1     2  2               |     25  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
      Dilatation                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Mineralization                       |             2                    3                                       |      2  2.5|
      Necrosis, Zenkers                    |                                                                          |      1  3.0|
      Artery, Mineralization               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Spindle Cell, Hyperplasia            |       3           2     1           1  2        3  2  1                  |     24  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia                          |                                              3                           |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +     +  +  +  M  +  +  +  +  +  +  M  +  M  +               |  48        |
      Ectopic Thymus                       |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  57        |
      Pars Distalis, Cyst                  |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                         1                          3                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  56        |
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |    2  2                                      2                           |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hematocyst                           |                                                                          |      2  3.0|
      Bilateral, Corpus Luteum, Cyst       |             3                                                            |      1  3.0|
      Follicle, Cyst                       |          3                                      3  3                     |      6  3.2|
      Follicle, Hematocyst                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hydrometra                           |       3  3                                                               |     12  3.2|
      Hyperplasia, Cystic                  | 3           3           3           2  2  3  3  3  2  2                  |     29  2.6|
      Inflammation, Suppurative            |       4           3                                                      |      3  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Pancreatic, Inflammation, Chronic    |                                                                          |            |
          Active                           |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  M  +               |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                     2           3                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  57        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  I  +  +  +  I  +  I  +  M               |  51        |
      Atrophy                              | 2                                                                        |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Alopecia                             |                   2                    2              1                  |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      4  2.0|
      Alveolus, Hemorrhage                 |                                                                          |      1  3.0|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      4  2.3|
      Bronchiole, Epithelium, Necrosis     |          2                       3                                       |      3  2.0|
      Peribronchial, Inflammation,         |                                                                          |            |
          Suppurative                      |                                  3                                       |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Lumen, Inflammation, Suppurative     |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      6  1.5|
      Nephropathy                          |                                                                          |      1  2.0|
      Collecting Tubule, Mineralization    |                                                                          |      1  3.0|
      Collecting Tubule, Necrosis,         |                                                                          |            |
          Coagulative                      |                                                                          |      1  2.0|
      Cortex, Cyst Multilocular            |                               2                                          |      1  2.0|
      Pelvis, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |       4  2        1                 2  2              2                  |      9  2.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
      Infiltration Cellular, Lymphocyte    |                                           1           2                  |     20  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|             
                                           | 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Lymphoid                |                4                                                         |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |                               2                                          |             
      Clear Cell Focus                     |                                                             2            |             
      Congestion                           |                                                 4                        |             
      Eosinophilic Focus                   |                                        3              2           2      |             
      Fatty Change                         |                   3                                                      |             
      Mixed Cell Focus                     |                2                    2                                    |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |                   3                    2  2  1                           |             
      Centrilobular, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                    +  +                    +     +      |             
      Inflammation, Granulomatous          |                                     4                                    |             
      Fat, Inflammation, Chronic           |                3                                                         |             
      Fat, Inflammation, Suppurative       |                                                                          |             
      Fat, Necrosis, Coagulative           |                                        3                    2     4      |             
      Fat, Necrosis, Liquifactive          |                4                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Granulomatous          |                                     4                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1                                               2  1                 2  1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                | 2                                                                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|             
                                           | 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Spindle Cell, Hyperplasia            |    1     1                                            2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Cytomegaly                           |                                                                          |             
      Hypertrophy                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  I  M  I  +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +                          +  +                          +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     | 4        4                          4  3                          3  4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Fibrosis                             |          3                                                               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|             
                                           | 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2                 3                          3            |             
      Inflammation, Granulomatous          |                                     3                                    |             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Amyloid Deposition                   |                2                                                         |             
      Angiectasis                          |                2                                                         |             
      Congestion                           |             2                                                            |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                  3                 3                    2|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Alopecia                             |                               2                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Metacarpal, Inflammation, Chronic    |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3        1                 1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|             
                                           | 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Retrobulbar, Infiltration Cellular,  |                                                                          |             
           Focal, Lymphocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                         +                              |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                           M                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Nephropathy                          |                         1           2  1     1              1            |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Cyst Multilocular            |    2                                                                     |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Renal Tubule, Mineralization         |                      1                                                   |             
      Renal Tubule, Necrosis, Coagulative  |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                            1         |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|             
                                           | 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  M  M  +     +  +  +  +  +  +        +        M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Hyperplasia, Lymphoid                |          3        2                                                  2   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  I  I  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                   2     2                 2                              |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                           2                          2   |             
      Fatty Change                         |                                                                          |             
      Mixed Cell Focus                     |                         3                                                |             
      Necrosis, Coagulative                |             3                                                  3         |             
      Vacuolization Cytoplasmic            |    3                             2           3        1                  |             
      Centrilobular, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                             +  +   |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                   4      |             
      Fat, Inflammation, Suppurative       |                                     4                                    |             
      Fat, Necrosis, Coagulative           |                                     4                                    |             
      Fat, Necrosis, Liquifactive          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  2  2     1           2              2                 1     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Hyperkeratosis                       |             3                                                            |             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|             
                                           | 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Spindle Cell, Hyperplasia            |       2     1           1        2        2           2        1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Clear Cell Focus                     |          2                                2                              |             
      Cytomegaly                           |                                                                         2|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  I  +  +  +  +     +  M  M  M  +  +        +        +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  M|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +     +           +                                +   |             
      Hyperplasia                          |                   3                                                      |             
      Inflammation, Suppurative            |                                                                      4   |             
      Duct, Dilatation                     |                         4           3                                    |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Dilatation                           |                                           3                              |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|             
                                           | 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +     +  M  +  +  +  +        +        +  +  +  +|             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Congestion                           |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |             X                                                            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                   2      |             
      Hyperplasia, Lymphoid                |          3                                                        2      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +     +  +  +  M  +  +        +        +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M  M  M  M     M  M  M  M  M  M        M        M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Alopecia                             |                                                       3                  |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Metacarpal, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|             
                                           | 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Retrobulbar, Infiltration Cellular,  |                                                                          |             
           Focal, Lymphocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Ectopic Tissue                       |                                           X                              |             
      Glomerulosclerosis                   |                2                                                         |             
      Infiltration Cellular, Lymphocyte    |             3  3                       1                                 |             
      Nephropathy                          |                                                                          |             
      Cortex, Cyst                         |                                                                2         |             
      Cortex, Cyst Multilocular            |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |    2  2                                      2                           |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis, Coagulative  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2                                            1                  |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  +  A  +  M  +  +        +  +  A  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      4  2.0|
      Congestion                           |                                                                          |      1  4.0|
      Eosinophilic Focus                   |                                  2                                       |      6  2.2|
      Fatty Change                         |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                  2                                       |      4  2.3|
      Necrosis, Coagulative                |                                  1                                       |      3  2.3|
      Vacuolization Cytoplasmic            | 2  3              2  2                                   3               |     13  2.2|
      Centrilobular, Hypertrophy           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Fat, Inflammation, Chronic           |                                                                          |      2  3.5|
      Fat, Inflammation, Suppurative       |                                                                          |      1  4.0|
      Fat, Necrosis, Coagulative           |                                                                          |      4  3.3|
      Fat, Necrosis, Liquifactive          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    | 1                 2     2                                                |     16  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperkeratosis                       |                3                                                         |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Ulcer                                |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
      Ulcer                                |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Spindle Cell, Hyperplasia            |       2                             1                                    |     12  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Clear Cell Focus                     |                            1                                             |      3  1.7|
      Cytomegaly                           |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +     +  +  +  +  +  M  M  M        +  +  M  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  I  +  +  +  +        M  +  M  +  +               |  52        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  58        |
      Follicular Cell, Cyst                | 2                                                                        |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                       +                  |   1        |
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                       4                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +     +           +        +           +                        |  16        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Duct, Dilatation                     |       4  3     3           3        4           3                        |     14  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Dilatation                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  59        |
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |            |
          Cell                             |                               2                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  59        |
      Congestion                           |                                                                          |      2  2.0|
      Hemorrhage                           |                         3                                                |      1  3.0|
      Hyperplasia, Lymphoid                |                               3                                          |      5  2.8|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                               2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      4  2.5|
      Hyperplasia, Lymphoid                |                               3                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  M  +        +  +  A  +  +               |  57        |
      Inflammation, Suppurative            |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M     M  M  M  M  +  M  M  M        M  M  M  M  M               |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Alopecia                             |    2                                                                     |      3  2.3|
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Metacarpal, Inflammation, Chronic    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
      Inflammation, Suppurative            |                                                       2                  |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   3        |
      Retrobulbar, Infiltration Cellular,  |                                                                          |            |
           Focal, Lymphocyte               |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Ectopic Tissue                       |                                                                          |      1     |
      Glomerulosclerosis                   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                         2     2                                          |      5  2.2|
      Nephropathy                          |       1        1                    2                                    |      8  1.3|
      Cortex, Cyst                         |                                                                          |      1  2.0|
      Cortex, Cyst Multilocular            |                                                                          |      1  2.0|
      Pelvis, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                   2  1                                                   |      5  1.8|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
      Renal Tubule, Necrosis, Coagulative  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  1.5|
      Inflammation, Chronic                |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|             
                                           | 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  M  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +     +  +  +  +        +  +  +  M  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  I  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |       2     2                             2                              |             
      Clear Cell Focus                     | 2                                               2              1         |             
      Eosinophilic Focus                   |                      2              4                       2            |             
      Mixed Cell Focus                     |                   2                                                      |             
      Necrosis, Coagulative                |    3                                                                     |             
      Syncytial Alteration                 |    2              1        1                                1     1      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Centrilobular, Hypertrophy           |                                                             2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Atrophy                              |                                                             2            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Coagulative                |                                                       4                  |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    | 1     1                             2  2        1     1        2     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
      Hyperkeratosis                       |    2                                                                     |             
      Hyperplasia, Squamous                |                                     2     3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  A  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Spindle Cell, Hyperplasia            |             2        3     2                 2                 2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  A  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Clear Cell Focus                     |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|             
                                           | 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  A  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     M  +  +  M        M  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +  +  +        +  A  +  M  +  +  +     +  +     +   |             
      Fibrosis                             |                                                                          |             
      Pars Distalis, Cyst                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicular Cell, Cyst                |             3                                                            |             
      Follicular Cell, Hyperplasia         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Granuloma                            |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                         1                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +     +        +  +              +              +        +   |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |             4     3        4  4              4              4        4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Atrophy                              |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +  M  M        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  I  +     +     +  +  +  +        +  +  +  M  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M     M  M  M  M        M  M  M  M  M  M  M     M  M     M   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|             
                                           | 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Alopecia                             |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Meninges, Fibrosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +|             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
      Bronchiole, Epithelium, Hyperplasia  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |                      2                                      2            |             
      Nephropathy                          |                   1  2                                1                  |             
      Cortex, Cyst Multilocular            |                                                                          |             
      Renal Tubule, Necrosis, Coagulative  |                      2     2                                             |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |                                        1           1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|             
                                           | 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    I  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +        +  +  +     +  +  +  +  +     +     +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |             3                                                            |             
      Eosinophilic Focus                   |       2  2  3  2  1                 3                                   2|             
      Mixed Cell Focus                     |    1     2                                                               |             
      Necrosis, Coagulative                |                                                                          |             
      Syncytial Alteration                 |                                                                          |             
      Vacuolization Cytoplasmic            |                            2                                             |             
      Centrilobular, Hypertrophy           |                                                          2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Fat, Necrosis, Coagulative           |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Atrophy                              |                                                          1               |             
      Infiltration Cellular, Lymphocyte    |                                                          1               |             
      Necrosis, Coagulative                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Infiltration Cellular, Lymphocyte    |                      1  1              1           1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Hyperkeratosis                       |                                                          2               |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Spindle Cell, Hyperplasia            |          2  3  3     2                             3                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Clear Cell Focus                     |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|             
                                           | 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Hyperplasia                          |                   4                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  +  +  +  +  +           I  +  +     +  M  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  M  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Fibrosis                             |                                                 3                        |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Infiltration Cellular, Lymphocyte    |                                                             2            |             
      Follicular Cell, Cyst                |                                                    2                     |             
      Follicular Cell, Hyperplasia         |                   2  2  1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Granuloma                            |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +     +        +                 +           +     +     +      |             
      Inflammation, Suppurative            |                3                                                         |             
      Duct, Dilatation                     |       4  3              4                 4           3     3            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Congestion                           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Congestion                           |                                                    2                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |       3                                                                  |             
      Hyperplasia, Lymphoid                |                                                                         3|             
      Lymphocyte, Atrophy                  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  M  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M  +  M  M           M  M  M     M  M  M  M  M     M     M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|             
                                           | 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +     +     +|             
      Alopecia                             |                                  2                    1                 3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Meninges, Fibrosis                   |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Nephropathy                          |          1        1                    3              1                 1|             
      Cortex, Cyst Multilocular            |                                                                          |             
      Renal Tubule, Necrosis, Coagulative  |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  54        |
      Basophilic Focus                     |                   3                                                      |      4  2.3|
      Clear Cell Focus                     |    2  2                                         2                        |      7  2.0|
      Eosinophilic Focus                   |    2                    2     2           2        2                     |     15  2.2|
      Mixed Cell Focus                     |                                                                          |      3  1.7|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Syncytial Alteration                 |                   1     1                                                |      7  1.1|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Centrilobular, Hypertrophy           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   3        |
      Fat, Necrosis, Coagulative           |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Atrophy                              |                               2                                          |      3  1.7|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Polyarteritis                        |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Infiltration Cellular, Lymphocyte    |       2              1  1  2  2           2     2                        |     19  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |                               2                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Spindle Cell, Hyperplasia            |                   1                                   2                  |     12  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Clear Cell Focus                     |                                                       2                  |      1  2.0|
      Cytoplasmic Alteration               | 2                                                                        |      1  2.0|
      Hypertrophy                          |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Hyperplasia                          |                   4                                                      |      3  3.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M     +  +  +  +  +  +  +           +     +  +  M                  |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +           M     +  +  +                  |  46        |
      Fibrosis                             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Follicular Cell, Cyst                |                                                                          |      2  2.5|
      Follicular Cell, Hyperplasia         |                      2                             2                     |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Granuloma                            | 3                                                                        |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +              +  +        +  +  +               |  21        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Duct, Dilatation                     |                         3              3  4        4  4  3               |     19  3.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Congestion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Lymphocyte, Atrophy                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +     +  +  +  +  +  +  +           +     +  +  +                  |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M     M  M  +  M  +  M  M           M     M  M  M                  |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  51        |
      Alopecia                             |                         1                                                |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Meninges, Fibrosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  52        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Infiltration Cellular, Lymphocyte    | 2                          3                                             |      4  2.3|
      Nephropathy                          |    1  1                 1                 1                              |     12  1.3|
      Cortex, Cyst Multilocular            |                                                 2                        |      1  2.0|
      Renal Tubule, Necrosis, Coagulative  |                                                                          |      2  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|             
                                           | 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Periesophageal Tissue, Edema         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Inflammation, Chronic                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +     +  +  +  +     +  +     +  +  +        +  +  +|             
      Basophilic Focus                     | 2                    2                                                   |             
      Clear Cell Focus                     |                   3                                2              1      |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |    2                                2              2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Syncytial Alteration                 | 2     1     1     1        1  1  1  2        2        1  2        1  2  1|             
      Vacuolization Cytoplasmic            |             2              3     2                                       |             
      Centrilobular, Hypertrophy           |             2                             2        2     2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Necrosis, Coagulative           |                   4                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Atrophy                              |                                                                          |             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Infiltration Cellular, Lymphocyte    |                   2  1                             1     2        1     1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Ulcer                                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|             
                                           | 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Spindle Cell, Hyperplasia            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Clear Cell Focus                     | 3                                                                        |             
      Cyst                                 |                                                       3                  |             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     M  +     +  +  +  +     +        +  M  +        +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +     +  +  +  +     I        +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Infiltration Cellular, Lymphocyte    |                                                    2                     |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +           +  +     +                              |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                      4           4  4     4                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Infiltration Cellular, Lymphocyte    |                                                       1                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Dilatation                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     M|             
      Congestion                           |                                                          4               |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +     +  +     +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|             
                                           | 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  M  +     +     +  +     +  +  I  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M     M  M     M  M  M  M     +        M  M  M        M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +     +  +  +  +     +  +     +  +  +        +     +|             
      Alopecia                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2                    1                                2      |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Bronchiole, Dilatation, Focal        |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                      1                                   1               |             
      Nephropathy                          |                                                    3     1               |             
      Collecting Tubule, Necrosis,         |                                                                          |             
          Coagulative                      |                            2                                             |             
      Cortex, Cyst                         |                   2                                                      |             
      Cortex, Cyst Multilocular            |                                                                          |             
      Renal Tubule, Necrosis, Coagulative  |                                                    3              2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Hemorrhage                           |                                           3                              |             
      Infiltration Cellular, Lymphocyte    |    1                 2                                   1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|             
                                           | 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +        +  +  I  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Periesophageal Tissue, Edema         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +        +  +  +  +  +  +     +  M     +  +  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |       3                                                        3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                  2                 2           1  2      |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                         1        2  3              2        3  1  2  4   |             
      Inflammation, Suppurative            |                                                          2               |             
      Mixed Cell Focus                     |                                              2                           |             
      Syncytial Alteration                 |    2  1        1  2  1  1        1  1     1        1     1  1  1     2   |             
      Vacuolization Cytoplasmic            |       3           1                             3                    2   |             
      Centrilobular, Hypertrophy           |    2  1              1  1  1     1  2     1           1     2  1  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Atrophy                              |                                                                          |             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |       2     1                             1        1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hyperplasia, Squamous                |                                     3                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|             
                                           | 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Spindle Cell, Hyperplasia            |                      2           1  2                       2     2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     M        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +        M  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     M        M  +  +  +  M  +     +  +     M  +  M  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicular Cell, Cyst                |                            2                                             |             
      Follicular Cell, Hyperplasia         |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +           +              +  +         |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                               4  4           4              4  4         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Atrophy                              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hyperplasia, Neutrophil              |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                          2     3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|             
                                           | 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +        +  +  +  I  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M     M        M  M  M  M  M  M     M  M     M  M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage                 |                                                                2         |             
      Bronchiole, Dilatation, Focal        |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Glomerulosclerosis                   |                               3                                          |             
      Infiltration Cellular, Lymphocyte    |             2                                      1                     |             
      Nephropathy                          |                               3                                      1   |             
      Collecting Tubule, Necrosis,         |                                                                          |             
          Coagulative                      |                                                                          |             
      Cortex, Cyst                         |                      2                                                   |             
      Cortex, Cyst Multilocular            |                                                                          |             
      Renal Tubule, Necrosis, Coagulative  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  49        |
      Periesophageal Tissue, Edema         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  M               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
      Hyperplasia, Lymphoid                |                                              3  3                        |      5  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +  M  +     +  +     +  +     +  +  +  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  56        |
      Basophilic Focus                     |                                                                          |      2  2.0|
      Clear Cell Focus                     |                                              2                           |      8  1.9|
      Congestion                           |                                                          4               |      1  4.0|
      Eosinophilic Focus                   |                                                 4  4                     |     13  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mixed Cell Focus                     |          3                 3        2                                    |      4  2.5|
      Syncytial Alteration                 |    1        1  1     2        1     1  1     2  2  1     1               |     39  1.3|
      Vacuolization Cytoplasmic            |    2  2     3  2                                                         |     11  2.3|
      Centrilobular, Hypertrophy           |                2     2        2     2  2     2  2                        |     23  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   3        |
      Fat, Necrosis, Coagulative           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Atrophy                              |                               3                                          |      1  3.0|
      Degeneration                         |             1                                                            |      1  1.0|
      Infiltration Cellular, Lymphocyte    |             1                                                            |      3  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                2     1        1        1                                 |     14  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
      Hyperplasia, Squamous                |                                              2  3                        |      3  2.7|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  49        |
      Spindle Cell, Hyperplasia            |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  49        |
      Clear Cell Focus                     |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Hyperplasia                          |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     M  M  +  +  +     +  +     +  +     +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  M  M               |  40        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Follicular Cell, Cyst                |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                      1                                                   |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                 +                 +     +                  |  13        |
      Inflammation, Suppurative            |                                                 4                        |      1  4.0|
      Duct, Dilatation                     |             4                 4                       4                  |     12  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +  +     I  +     +  +     +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +  +  M  +     I  +     +  +     +  +  +  +  +               |  48        |
      Hyperplasia, Lymphoid                |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  47        |
      Congestion                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     +  +  I  +  +     +  +     +  +     +  +  +  +  +               |  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     M  +  M  M  M     M  M     M  M     M  M  M  M  M               |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  51        |
      Alopecia                             |          2                                                               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  51        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                          1               |      4  1.5|
      Alveolus, Hemorrhage                 |    2                                                                     |      2  2.0|
      Bronchiole, Dilatation, Focal        |       3                                                                  |      1  3.0|
      Pleura, Inflammation, Suppurative    |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  1.3|
      Nephropathy                          | 4           1        2                 1                                 |      8  2.0|
      Collecting Tubule, Necrosis,         |                                                                          |            |
          Coagulative                      |                                                                          |      1  2.0|
      Cortex, Cyst                         |                               2     2                                    |      4  2.0|
      Cortex, Cyst Multilocular            | 4                                                                        |      1  4.0|
      Renal Tubule, Necrosis, Coagulative  |                                                    2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    | 1                                                                        |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    4                     |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +     I  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          4                                      3                        |             
      Basophilic Focus                     |                                                 2                        |             
      Clear Cell Focus                     |                   2              2                                       |             
      Congestion                           |          4                                      4                        |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |          3  X                       3              2        4  2         |             
      Fatty Change                         |                                                                          |             
      Mixed Cell Focus                     |                                           2                              |             
      Necrosis, Coagulative                | 3        3                                      3                        |             
      Syncytial Alteration                 | 2  2  2  2  2  2  2  2     2        2  1  2     1  1  2  2  2  2  2  2  2|             
      Vacuolization Cytoplasmic            |    1                                      2              2               |             
      Centrilobular, Hypertrophy           |    3  3     2  2  2  1        2  2  1  1     2  2  2  2  1  2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Hemorrhage                      |                      2                                                   |             
      Fat, Inflammation, Chronic           |                      3                                                   |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1                                                      |             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2                    2                       2              2  1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             1                                                            |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Mineralization                       | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Hyperplasia            |                1  2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  M  M  +  +  M  M  +  M  +  +  +  M  +  I  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                             2            |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Papillary                        |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                            1                                             |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                       +              +     +     +         |             
      Duct, Dilatation                     |             4                       4              4           3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2                 2     1                                             |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  I  M  I  +  +  M  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Ulcer                                |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            | 3                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                      2   |             
      Bronchiole, Epithelium, Necrosis     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Lumen, Inflammation, Suppurative     |                1                             3                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            1                       3        2            |             
      Nephropathy                          |                                                                   2      |             
      Collecting Tubule, Necrosis,         |                                                                          |             
          Coagulative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2              1                                                     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +  +     +  A  +     +        A  M  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +  +     +  A  +     +        A  A  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +     +  A  +     +        A  A  +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |             2                                2                    1  1   |             
      Congestion                           |                         3                       4     4                 4|             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                4     2     4                       2                     |             
      Fatty Change                         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                 4  4  2                 3|             
      Syncytial Alteration                 |    2  2     2  2     1  2  2     2        2  2  2  3  3     2  2  2  2  2|             
      Vacuolization Cytoplasmic            |             3                                                            |             
      Centrilobular, Hypertrophy           |    2  2     1  1     2  1  1     3        2  2  1              2  1  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis, Coagulative           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +     +  A  +     +        +  +  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2  2        1     2     1                    1     2        1         |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +  +     +  +  +     +        A  A  +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +  +     +  +  +     +        A  A  +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +  +     +  A  +     +        A  A  +  +  +     +  +  +  +  A|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                    2                 2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Spindle Cell, Hyperplasia            |                2                 2                             2     2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |                                                       3                  |             
      Clear Cell Focus                     |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +     +  +  +     +        +  M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +     +  A  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +  +     +  M  M     +        +  M  +  +  +     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +     +        +  M  +  +  +     +  +  I  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Papillary                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +                 +         |             
      Duct, Dilatation                     |                                                                3         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  +     M  +  +     M        +  M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                           4        3                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +     +  +  +     +        I  +  +  M  +     +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M     +  M     M  M  M     M        M  M  M  M  M     M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Congestion                           |                         3                    3                           |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       3                                            2                    2|             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Bronchiole, Epithelium, Necrosis     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Lumen, Inflammation, Suppurative     |                            2                                         2   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Glomerulosclerosis                   |                                           3                              |             
      Infiltration Cellular, Lymphocyte    |       1                                                                  |             
      Nephropathy                          |                                                                          |             
      Collecting Tubule, Necrosis,         |                                                                          |             
          Coagulative                      |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
      Inflammation, Chronic Active         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +     +  A  +     +        A  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2        1                                                     1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +     +  +  M  +  +  M  +  +  A  +  +  +  +  +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Angiectasis                          |                                                                          |      2  3.5|
      Basophilic Focus                     |    2                                                     2               |      3  2.0|
      Clear Cell Focus                     |                      2        2           2  2        2                  |     11  1.8|
      Congestion                           |       4                                                                  |      7  3.9|
      Developmental Malformation           |                                                    X                     |      1     |
      Eosinophilic Focus                   |                      3           3           1  3  2                     |     15  2.7|
      Fatty Change                         |                                        2                                 |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                     4                                    |      8  3.3|
      Syncytial Alteration                 |    2  3     2  2  2  1  2  2  2  2  2  2  2  2  2  1  2                  |     56  1.9|
      Vacuolization Cytoplasmic            |                2     2                                                   |      6  2.0|
      Centrilobular, Hypertrophy           |    2  1     2  2  3     2  3  3  2  1  2  2  1  2  1  3  1               |     52  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   3        |
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Necrosis, Coagulative           |                      3                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Atrophy                              |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                              2           2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |             2  2              2        2     1  1  1  2                  |     21  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  A     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  53        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Mineralization                       |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                                 1                        |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                     1                                    |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  59        |
      Spindle Cell, Hyperplasia            |                                  2        2  1     2                     |     10  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  59        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M     +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  M     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Follicular Cell, Cyst                |                                                    3                     |      1  3.0|
      Follicular Cell, Hyperplasia         |    2                                                                     |      2  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Papillary                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +        +                                                |   9        |
      Duct, Dilatation                     |                4        4                                                |      7  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  56        |
      Congestion                           |                                  2                                       |      3  3.0|
      Hyperplasia, Lymphoid                |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  M     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M               |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Alopecia                             |                                           2                              |      1  2.0|
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Congestion                           |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                2                                                         |      5  2.2|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Bronchiole, Epithelium, Necrosis     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Fungus                               |                                                          3               |      1  3.0|
      Inflammation, Suppurative            |                                                          3               |      1  3.0|
      Lumen, Inflammation, Suppurative     |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05090-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 12:04:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   1        |
      Inflammation, Chronic, Diffuse       |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Fibrosis                             |                                                                          |      1  2.0|
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |             2                                                            |      5  1.8|
      Nephropathy                          |                   2     2                                                |      3  2.0|
      Collecting Tubule, Necrosis,         |                                                                          |            |
          Coagulative                      |                                                                          |      1  2.0|
      Glomerulus, Inflammation, Chronic    |                                                          3               |      1  3.0|
      Pelvis, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  57        |
      Infiltration Cellular, Lymphocyte    |             1              2                          2                  |      9  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
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