Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1214

TDMS Study 05090-01 Pathology Tables

NTP Experiment-Test: 05090-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/17/96
Route: GAVAGE                                                                                                     Time: 10:54:22

                                                      39 WEEK STOP ANIMALS




       Facility:  American Biogenics Corp.

       Chemical CAS #:  000091645

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    25004 Dead                              25014 Gavage Death
                               25003 Moribund                          25006 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 011    100MG/KG 39 STOP

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05090-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:54:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2|              |            |
                                           | 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     39 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +               |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +               |  17        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +               |  18        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +               |  17        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  A  +  +  +               |  17        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                    X  X           X                           |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +     +  +     +        +  +                                       |   7        |
      Mesothelioma NOS                     |                X                                                         |          1 |
      Fat, Leukemia Mononuclear            |                               X  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  19        |
      Adenoma                              |          X                                                               |          1 |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |                                  X           X                           |          2 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   1        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Fibrosarcoma                         |                                                 X                        |          1 |
      Leukemia Mononuclear                 |                               X              X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05090-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:54:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2|              |            |
                                           | 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     39 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
      Pheochromocytoma Benign              |             X                                X  X  X                     |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  19        |
      Adenoma                              |                                     X                                    |          1 |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Adenoma                              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X              X                           |          2 |
      Pars Distalis, Adenoma               | X     X  X  X                                                            |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   1        |
      Mesothelioma NOS                     |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Mesothelioma NOS                     |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Adenoma                              |                                                 X                        |          1 |
      Carcinoma                            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Interstitial Cell, Adenoma           | X  X  X  X  X  X  X  X  X     X  X  X     X  X  X  X  X  X               |         18 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Lumbar, Leukemia Mononuclear         |                                  X                                       |          1 |
      Mediastinal, Leukemia Mononuclear    |                                              X                           |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05090-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:54:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2|              |            |
                                           | 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     39 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |          X              X     X  X           X                           |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X              X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Fibroadenoma                         |          X  X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  19        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                         X     X  X           X                           |          4 |
      Squamous Cell Carcinoma              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
      Renal Tubule, Adenoma                |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X              X     X  X           X                           |          5 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05090-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:54:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7|              |            |
                             DAY ON TEST   | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2|              |            |
                                           | 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     39 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma NOS                     |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------