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https://ntp.niehs.nih.gov/go/1133

TDMS Study 05090-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              COUMARIN


NTP Experiment-Test: 05090-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 03:12:33




       Facility:  American Biogenics Corp.

       Chemical CAS #:  000091645

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          14            7            7           14                                     
    Dead                                               5            4            2            6                                     
    Gavage Death                                       2            1            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           38           35           30                                     
    Dead                                                                         1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (56)         (47)         (49)         (55)                                   
   Intestine Large, Colon                             (57)         (48)         (49)         (57)                                   
   Intestine Large, Rectum                            (58)         (49)         (48)         (58)                                   
   Intestine Small, Ileum                             (56)         (47)         (48)         (56)                                   
   Intestine Small, Jejunum                           (56)         (48)         (48)         (56)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Liver                                              (60)         (58)         (58)         (60)                                   
   Mesentery                                          (3)          (8)          (10)         (7)                                    
      Sarcoma                                                                                 1 (14%)                               
   Pancreas                                           (59)         (49)         (48)         (56)                                   
   Pharynx                                                                                   (2)                                    
      Squamous Cell Papilloma                                                                 2 (100%)                              
   Salivary Glands                                    (60)         (50)         (50)         (60)                                   
   Stomach, Forestomach                               (58)         (50)         (50)         (58)                                   
      Squamous Cell Papilloma                          1 (2%)       3 (6%)                    1 (2%)                                
   Stomach, Glandular                                 (58)         (50)         (49)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (48)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (50)         (48)         (59)                                   
      Pheochromocytoma Benign                          3 (5%)       2 (4%)       2 (4%)       1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (59)         (49)         (48)         (57)                                   
      Adenoma                                          1 (2%)                    1 (2%)       2 (4%)                                
   Pituitary Gland                                    (58)         (48)         (48)         (59)                                   
      Pars Distalis, Adenocarcinoma                    1 (2%)                                                                       
      Pars Distalis, Adenoma                          30 (52%)     26 (54%)     23 (48%)     28 (47%)                               
   Thyroid Gland                                      (59)         (50)         (49)         (59)                                   
      C-Cell, Adenoma                                                                         1 (2%)                                
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                                    (1)                                    
      Fibroma                                          1 (50%)                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (47)         (49)         (59)                                   
      Adenoma                                                       6 (13%)                   2 (3%)                                
      Carcinoma                                                     1 (2%)       1 (2%)       2 (3%)                                
   Ovary                                              (60)         (50)         (50)         (59)                                   
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
   Oviduct                                                                      (1)                                                 
   Uterus                                             (60)         (51)         (52)         (59)                                   
      Polyp                                            8 (13%)     14 (27%)      6 (12%)      7 (12%)                               
      Sarcoma                                                                                 1 (2%)                                
   Vagina                                             (1)          (1)                       (4)                                    
      Leiomyoma                                                     1 (100%)                                                        
      Leiomyosarcoma                                                                          1 (25%)                               
      Sarcoma                                                                                 1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (49)         (59)                                   
   Lymph Node                                         (59)         (50)         (50)         (59)                                   
   Lymph Node, Mandibular                             (59)         (47)         (48)         (57)                                   
   Lymph Node, Mesenteric                             (57)         (49)         (49)         (59)                                   
   Spleen                                             (59)         (51)         (49)         (59)                                   
   Thymus                                             (58)         (48)         (49)         (56)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (50)         (50)         (59)                                   
      Adenocarcinoma                                   1 (2%)                                 1 (2%)                                
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Fibroadenoma                                    17 (29%)     24 (48%)     22 (44%)     11 (19%)                               
      Fibrosarcoma                                                               1 (2%)                                             
   Skin                                               (60)         (50)         (51)         (60)                                   
      Lipoma                                                                     1 (2%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (50)         (60)                                   
   Skeletal Muscle                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (59)                                   
      Meninges, Meningioma NOS                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (49)         (50)         (60)                                   
      Adenoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Eye                                                (1)          (4)          (1)          (1)                                    
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Zymbal's Gland                                                               (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (58)         (60)         (59)                                   
      Lipoma                                                        1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
      Renal Tubule, Adenoma                                                                   2 (3%)                                
                                                             Page   4                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
   Urinary Bladder                                    (59)         (49)         (49)         (57)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                             6 (10%)      5 (8%)       6 (10%)      4 (7%)                                
      Mesothelioma NOS                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          46          42          45                                       
     Total Primary Neoplasms                           76          93          73          78                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          45          38          42                                       
     Total Benign Neoplasms                            65          86          62          63                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              10           7          10          11                                       
     Total Malignant Neoplasms                         10           7          10          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1                                                   
     Total Uncertain Neoplasms                          1                       1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20           10           60           60           60           
  Scheduled Sacrifice                                 10           17            7           10            9           10           
  Early Deaths                                                                                                                      
    Moribund                                          14                                     31           33           31           
    Gavage Death                                       2            2            3            3            2            2           
    Dead                                               6            1                         7           13           17           
    Moribund Sacrifice                                                                                     1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                      9            2                        
  Animals Examined Microscopically                    59           20           10           60           60           60           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (55)         (2)          (10)         (48)         (42)         (54)         
      Adenoma, Papillary                                                                                   1 (2%)                   
   Intestine Small                                    (55)         (2)          (9)          (47)         (47)         (54)         
      Adenocarcinoma                                                                                       1 (2%)                   
   Intestine Small, Duodenum                          (56)         (2)          (9)          (48)         (48)         (56)         
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
   Intestine Small, Ileum                             (55)         (1)          (9)          (46)         (43)         (52)         
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
   Intestine Small, Jejunum                           (55)         (2)          (9)          (47)         (45)         (54)         
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
   Liver                                              (59)         (20)         (10)         (60)         (60)         (60)         
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
      Hemangiosarcoma                                                                                                   1 (2%)      
      Hepatocellular Carcinoma                         2 (3%)                                                                       
      Hepatocellular Adenoma                                                                                            1 (2%)      
   Mesentery                                          (21)         (1)          (3)          (12)         (18)         (7)          
      Fibrosarcoma, Metastatic                         1 (5%)                                                                       
   Pancreas                                           (57)         (20)         (9)          (49)         (50)         (59)         
      Adenoma                                          1 (2%)                                 2 (4%)       3 (6%)                   
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
   Pharynx                                            (1)                                    (1)          (2)                       
      Carcinoma                                                                                            1 (50%)                  
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)     1 (50%)                  
   Stomach, Forestomach                               (58)         (20)         (10)         (51)         (51)         (60)         
      Squamous Cell Papilloma                                                                 2 (4%)                    2 (3%)      
   Stomach, Glandular                                 (57)         (20)         (10)         (48)         (49)         (60)         
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
   Tooth                                                                                     (1)                                    
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (20)         (10)         (49)         (51)         (60)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (19)         (10)         (50)         (50)         (60)         
   Adrenal Gland, Medulla                             (59)         (19)         (10)         (50)         (50)         (60)         
      Pheochromocytoma Benign                          9 (15%)                                5 (10%)      5 (10%)                  
   Islets, Pancreatic                                 (57)         (3)          (9)          (50)         (50)         (59)         
      Adenoma                                          4 (7%)                                 1 (2%)       2 (4%)                   
   Parathyroid Gland                                  (51)         (19)         (10)         (47)         (49)         (57)         
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (58)         (20)         (10)         (48)         (51)         (60)         
      Pars Distalis, Adenoma                          20 (34%)                   1 (10%)     12 (25%)     18 (35%)      8 (13%)     
   Thyroid Gland                                      (57)         (20)         (10)         (49)         (49)         (60)         
      C-Cell, Adenoma                                  1 (2%)                                 1 (2%)       1 (2%)                   
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (5%)                    3 (6%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                                                 (1)          (1)          
      Adenocarcinoma                                   1 (50%)                                                                      
      Fibrosarcoma                                     1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (55)         (20)         (10)         (50)         (46)         (60)         
   Preputial Gland                                    (55)         (3)          (10)         (49)         (50)         (56)         
      Adenoma                                          2 (4%)                                 1 (2%)       1 (2%)                   
      Carcinoma                                        1 (2%)                                 1 (2%)                    1 (2%)      
   Prostate                                           (55)         (20)         (10)         (50)         (50)         (59)         
   Seminal Vesicle                                    (55)         (20)         (10)         (50)         (50)         (59)         
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
   Testes                                             (55)         (20)         (10)         (58)         (54)         (60)         
      Interstitial Cell, Adenoma                      46 (84%)                   7 (70%)     52 (90%)     50 (93%)     54 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                    (1)                                    
   Bone Marrow                                        (58)         (3)          (10)         (50)         (50)         (60)         
   Lymph Node                                         (59)         (20)         (10)         (50)         (49)         (58)         
   Lymph Node, Mandibular                             (57)         (20)         (10)         (47)         (48)         (58)         
   Lymph Node, Mesenteric                             (53)         (4)          (10)         (50)         (48)         (60)         
   Spleen                                             (58)         (20)         (10)         (50)         (51)         (60)         
      Hemangiosarcoma                                                                                                   1 (2%)      
   Thymus                                             (57)         (3)          (10)         (48)         (48)         (56)         
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (2)          (10)         (46)         (44)         (54)         
      Adenoma                                                                                                           1 (2%)      
      Fibroadenoma                                     4 (7%)                                 1 (2%)       2 (5%)                   
   Skin                                               (59)         (4)          (10)         (50)         (51)         (60)         
      Basal Cell Adenoma                               1 (2%)                                                                       
      Fibroma                                                                                              1 (2%)                   
      Keratoacanthoma                                                                         1 (2%)                    1 (2%)      
      Squamous Cell Carcinoma                                                                              1 (2%)                   
      Squamous Cell Papilloma                          1 (2%)                                 3 (6%)                    1 (2%)      
      Face, Squamous Cell Papilloma                                                           1 (2%)                                
      Pinna, Squamous Cell Papilloma                                                          1 (2%)                                
      Sebaceous Gland, Adenoma                                                                1 (2%)                                
      Subcutaneous Tissue, Fibroma                     2 (3%)                                              1 (2%)                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (3)          (10)         (50)         (51)         (60)         
      Chordoma                                         1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                 (2)          (1)          
      Fibrosarcoma, Metastatic                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (20)         (9)          (50)         (49)         (59)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (20)         (10)         (49)         (51)         (60)         
      Adenocarcinoma, Metastatic                       1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                 2 (4%)       1 (2%)       1 (2%)      
      Fibrosarcoma                                     1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (3)          (1)                       
      Fibroma                                                                                 1 (33%)                               
      Squamous Cell Papilloma                                                                 1 (33%)      1 (100%)                 
   Eye                                                                                                    (4)          (1)          
      Squamous Cell Papilloma                                                                              1 (25%)                  
   Zymbal's Gland                                                                            (2)          (1)          (1)          
      Carcinoma                                                                               2 (100%)                  1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (19)         (10)         (60)         (60)         (60)         
      Adenoma                                                                                 1 (2%)                                
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                 1 (2%)       3 (5%)       1 (2%)      
   Urethra                                                                                   (1)                                    
   Urinary Bladder                                    (55)         (20)         (10)         (49)         (50)         (59)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(59)        *(20)        *(10)        *(60)        *(60)        *(60)         
      Leukemia Mononuclear                             8 (14%)                               10 (17%)      1 (2%)       1 (2%)      
      Mesothelioma NOS                                 1 (2%)                                              1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            55           1           8          55          55          57               
     Total Primary Neoplasms                          115           1           8         108          97          76               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 54           1           8          55          54          56               
     Total Benign Neoplasms                            95           1           8          94          92          70               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16                                  13           4           4               
     Total Malignant Neoplasms                         19                                  14           4           5               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                   1                                       
     Total Metastatic Neoplasm                         11                                   1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                               1           1               
     Total Uncertain Neoplasms                          3                                               1           3               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          20           20           10           20                                     
  Scheduled Sacrifice                                 18                        10                                                  
  Early Deaths                                                                                                                      
    Gavage Death                                       2            1                         3                                     
    Moribund                                                        6                        13                                     
    Dead                                                            4                         2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                              8                         2                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    20           20           10           20                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (2)          (17)         (10)         (20)                                   
   Intestine Large, Colon                             (2)          (18)         (10)         (20)                                   
   Intestine Large, Rectum                            (2)          (18)         (10)         (20)                                   
   Intestine Small, Duodenum                          (2)          (18)         (10)         (20)                                   
   Intestine Small, Ileum                             (2)          (17)         (10)         (20)                                   
   Intestine Small, Jejunum                           (2)          (17)         (10)         (20)                                   
   Liver                                              (20)         (20)         (10)         (20)                                   
      Hepatocellular Adenoma                                                                  1 (5%)                                
   Mesentery                                          (1)          (7)          (1)          (4)                                    
   Pancreas                                           (20)         (19)         (10)         (20)                                   
      Adenoma                                                       1 (5%)                                                          
   Stomach, Forestomach                               (20)         (19)         (10)         (19)                                   
   Stomach, Glandular                                 (20)         (18)         (10)         (20)                                   
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (20)         (10)         (20)                                   
      Fibrosarcoma                                                  1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (20)         (10)         (20)                                   
   Adrenal Gland, Medulla                             (20)         (20)         (10)         (20)                                   
      Pheochromocytoma Benign                                       4 (20%)                   1 (5%)                                
   Islets, Pancreatic                                 (2)          (19)         (10)         (20)                                   
                                                             Page  12                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                                       1 (5%)                                                          
   Parathyroid Gland                                  (20)         (19)         (10)         (18)                                   
      Adenoma                                                       1 (5%)                                                          
   Pituitary Gland                                    (20)         (20)         (10)         (20)                                   
      Pars Distalis, Adenoma                                        4 (20%)      2 (20%)      5 (25%)                               
   Thyroid Gland                                      (20)         (20)         (10)         (20)                                   
      Follicular Cell, Carcinoma                                                              1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (20)         (20)         (10)         (20)                                   
   Preputial Gland                                    (3)          (19)         (10)         (20)                                   
      Adenoma                                                       1 (5%)                                                          
      Carcinoma                                                     1 (5%)                                                          
   Seminal Vesicle                                    (20)         (20)         (10)         (20)                                   
   Testes                                             (20)         (20)         (10)         (20)                                   
      Interstitial Cell, Adenoma                       1 (5%)      18 (90%)     10 (100%)    15 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (2)          (19)         (10)         (20)                                   
   Lymph Node                                         (20)         (20)         (10)         (20)                                   
   Lymph Node, Mandibular                             (20)         (20)         (9)          (20)                                   
   Lymph Node, Mesenteric                             (3)          (20)         (10)         (20)                                   
   Spleen                                             (20)         (19)         (10)         (20)                                   
   Thymus                                             (2)          (20)         (10)         (19)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (2)          (20)         (10)         (16)                                   
      Fibroadenoma                                                  2 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (2)          (20)         (10)         (20)                                   
      Lumbar, Vertebra, Sarcoma                                                               1 (5%)                                
   Skeletal Muscle                                                                           (1)                                    
      Back, Sarcoma                                                                           1 (100%)                              
                                                             Page  13                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (19)         (10)         (20)                                   
      Squamous Cell Carcinoma, Metastatic                                                     1 (5%)                                
   Spinal Cord                                        (2)                                    (1)                                    
      Meninges, Sarcoma                                                                       1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (20)         (10)         (20)                                   
      Squamous Cell Carcinoma                                       1 (5%)                                                          
   Nose                                               (2)          (20)         (10)         (20)                                   
      Polyp                                                                                   1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      Basal Cell Adenoma                                                                      1 (100%)                              
   Zymbal's Gland                                                                            (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (10)         (20)                                   
      Renal Tubule, Adenoma                                         1 (5%)                    2 (10%)                               
      Renal Tubule, Oncocytoma Benign                                                         2 (10%)                               
   Urinary Bladder                                    (20)         (20)         (10)         (20)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(20)        *(20)        *(10)        *(20)                                   
      Leukemia Mononuclear                                          5 (25%)                   4 (20%)                               
      Mesothelioma NOS                                              1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05090-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             1          18          10          17                                       
     Total Primary Neoplasms                            1          43          12          37                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  1          18          10          16                                       
     Total Benign Neoplasms                             1          34          12          28                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           8                       7                                       
     Total Malignant Neoplasms                                      8                       9                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                  1                                       
     Total Metastatic Neoplasm                                                              1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      3                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
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                             ----------              END OF REPORT             ----------                                           
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