TDMS Study 05093-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROANILINE DATE: 09/12/94
EXPERIMENT: 05093 TEST: 01 TIME: 21:32:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45038 ROUTE: GAVAGE NTP C#: 60786B
PATHOLOGIST: H. GILES S. EUSTIS CAS: 100-01-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROANILINE DATE: 09/12/94
EXPERIMENT: 05093 TEST: 01 TIME: 21:32:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: GAVAGE NTP C#: 60786B
PATHOLOGIST: H. GILES S. EUSTIS CAS: 100-01-6
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROANILINE DATE: 09/12/94
EXPERIMENT: 05093 TEST: 01 TIME: 21:32:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: GAVAGE NTP C#: 60786B
PATHOLOGIST: H. GILES S. EUSTIS CAS: 100-01-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF P-NITROANILINE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Spleen Hemangiosarcoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/70 (0%) 1/70 (1%) 1/70 (1%) | 0/70 (0%) 1/70 (1%) 2/70 (3%) 0/70 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 2.8% 2.6% | 0.0% 2.4% 6.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 0/32 (0%) 1/36 (3%) 1/39 (3%) | 0/29 (0%) 1/41 (2%) 2/32 (6%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 721 --- 729 (T) 729 (T) | --- 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.572 P=0.538N P=0.756N P=0.736N | P=0.513N P=0.569 P=0.260 (e) |
|INCIDENTAL TUMOR | P=0.538 P=0.500N P=0.727 P=0.752 | P=0.513N P=0.569 P=0.260 (e) |
|LOGISTIC REGRESSION | P=0.562 P=0.517N P=0.761 P=0.748N | P=0.513N P=0.569 P=0.260 (e) |
|COCHRAN-ARMITAGE | P=0.527 | P=0.490N |
|FISHER EXACT | P=0.500N P=0.752N P=0.752N | P=0.500 P=0.248 (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/70 (0%) 2/70 (3%) 1/70 (1%) | 1/70 (1%) 1/70 (1%) 2/70 (3%) 0/70 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 5.0% 2.6% | 3.4% 2.4% 6.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 0/32 (0%) 1/36 (3%) 1/39 (3%) | 1/29 (3%) 1/41 (2%) 2/32 (6%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 721 --- 631 729 (T) | 729 (T) 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.585 P=0.538N P=0.504 P=0.736N | P=0.352N P=0.683N P=0.535 P=0.480N |
|INCIDENTAL TUMOR | P=0.489 P=0.500N P=0.464 P=0.752 | P=0.352N P=0.683N P=0.535 P=0.480N |
|LOGISTIC REGRESSION | P=0.559 P=0.517N P=0.496 P=0.748N | P=0.352N P=0.683N P=0.535 P=0.480N |
|COCHRAN-ARMITAGE | P=0.539 | P=0.331N |
|FISHER EXACT | P=0.500N P=0.500 P=0.752N | P=0.752N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/70 (0%) 1/70 (1%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) 1/70 (1%) 0/70 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 2.8% 4.7% | 0.0% 0.0% 2.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 0/32 (0%) 1/36 (3%) 1/39 (3%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 667 --- 729 (T) 656 | --- --- 654 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260 P=0.520N P=0.751N P=0.533 | P=0.778N (e) P=0.525 (e) |
|INCIDENTAL TUMOR | P=0.212 P=0.500N P=0.727 P=0.461 | P=0.701N (e) P=0.540 (e) |
|LOGISTIC REGRESSION | P=0.234 P=0.504N P=0.760 P=0.510 | P=0.783N (e) P=0.505 (e) |
|COCHRAN-ARMITAGE | P=0.219 | P=0.785N |
|FISHER EXACT | P=0.500N P=0.752N P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Ear |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/70 (0%) 2/70 (3%) 0/70 (0%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 3.0% 0.0% 5.6% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/33 (3%) 0/32 (0%) 2/36 (6%) 0/39 (0%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423N P=0.506N P=0.530 P=0.467N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.423N P=0.506N P=0.530 P=0.467N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.423N P=0.506N P=0.530 P=0.467N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.473N | (e) |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 5/70 (7%) 3/70 (4%) 7/70 (10%) | 3/70 (4%) 3/70 (4%) 4/70 (6%) 5/70 (7%) |
|ADJUSTED (b) | 11.5% 12.9% 7.8% 17.0% | 9.9% 7.1% 12.5% 13.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/33 (9%) 2/32 (6%) 2/36 (6%) 5/39 (13%) | 2/29 (7%) 2/41 (5%) 4/32 (13%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 724 525 631 724 | 725 700 729 (T) 708 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.305 P=0.471 P=0.467N P=0.355 | P=0.238 P=0.515N P=0.551 P=0.429 |
|INCIDENTAL TUMOR | P=0.187 P=0.489 P=0.497N P=0.292 | P=0.344 P=0.655 P=0.562 P=0.465 |
|LOGISTIC REGRESSION | P=0.244 P=0.477 P=0.506N P=0.308 | P=0.275 P=0.571N P=0.563 P=0.593N |
|COCHRAN-ARMITAGE | P=0.207 | P=0.265 |
|FISHER EXACT | P=0.500 P=0.500N P=0.266 | P=0.660N P=0.500 P=0.359 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/70 (3%) 2/70 (3%) 0/70 (0%) | 1/70 (1%) 0/70 (0%) 2/70 (3%) 0/70 (0%) |
|ADJUSTED (b) | 3.0% 5.6% 5.0% 0.0% | 2.2% 0.0% 6.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/33 (3%) 0/32 (0%) 1/36 (3%) 0/39 (0%) | 0/29 (0%) 0/41 (0%) 1/32 (3%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 681 631 --- | 534 --- 723 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.201N P=0.475 P=0.520 P=0.467N | P=0.480N P=0.487N P=0.519 P=0.496N |
|INCIDENTAL TUMOR | P=0.277N P=0.496 P=0.520 P=0.467N | P=0.405N P=0.814N P=0.509 P=0.545N |
|LOGISTIC REGRESSION | P=0.218N P=0.478 P=0.496 P=0.467N | P=0.469N P=0.512N P=0.510 P=0.506N |
|COCHRAN-ARMITAGE | P=0.232N | P=0.473N |
|FISHER EXACT | P=0.500 P=0.500 P=0.500N | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 6/70 (9%) 4/70 (6%) 7/70 (10%) | 4/70 (6%) 3/70 (4%) 6/70 (9%) 5/70 (7%) |
|ADJUSTED (b) | 11.5% 15.5% 10.5% 17.0% | 11.9% 7.1% 18.1% 13.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/33 (9%) 2/32 (6%) 3/36 (8%) 5/39 (13%) | 2/29 (7%) 2/41 (5%) 5/32 (16%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 724 525 631 724 | 534 700 723 708 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 P=0.342 P=0.606N P=0.355 | P=0.338 P=0.357N P=0.423 P=0.569 |
|INCIDENTAL TUMOR | P=0.253 P=0.360 P=0.634N P=0.292 | P=0.480 P=0.622N P=0.426 P=0.591 |
|LOGISTIC REGRESSION | P=0.324 P=0.345 P=0.638 P=0.308 | P=0.383 P=0.434N P=0.409 P=0.554 |
|COCHRAN-ARMITAGE | P=0.278 | P=0.368 |
|FISHER EXACT | P=0.372 P=0.641N P=0.266 | P=0.500N P=0.372 P=0.500 |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) 0/70 (0%) 0/70 (0%) | 0/70 (0%) 2/70 (3%) 1/70 (1%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 6.3% 0.0% 0.0% | 0.0% 4.9% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 2/32 (6%) 0/36 (0%) 0/39 (0%) | 0/29 (0%) 2/41 (5%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- | --- 729 (T) 667 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.294N P=0.231 (e) (e) | P=0.349N P=0.317 P=0.520 (e) |
|INCIDENTAL TUMOR | P=0.294N P=0.231 (e) (e) | P=0.305N P=0.317 P=0.540 (e) |
|LOGISTIC REGRESSION | P=0.294N P=0.231 (e) (e) | P=0.334N P=0.317 P=0.506 (e) |
|COCHRAN-ARMITAGE | P=0.326N | P=0.339N |
|FISHER EXACT | P=0.248 (e) (e) | P=0.248 P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 1/70 (1%) 3/70 (4%) 4/70 (6%) | 1/70 (1%) 1/70 (1%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 7.4% 9.6% | 2.9% 2.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 1/32 (3%) 2/36 (6%) 3/39 (8%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 452 (I) 563 | 701 553 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065 P=0.494 P=0.133 P=0.083 | P=0.307N P=0.728N P=0.484N P=0.478N |
|INCIDENTAL TUMOR | P=0.048 * P=0.494 P=0.133 P=0.056 | P=0.358N P=0.608 P=0.460N P=0.443N |
|LOGISTIC REGRESSION | P=0.048 * P=0.494 P=0.121 P=0.067 | P=0.306N P=0.753N P=0.489N P=0.483N |
|COCHRAN-ARMITAGE | P=0.043 * | P=0.307N |
|FISHER EXACT | P=0.500 P=0.122 P=0.060 | P=0.752N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/70 (29%) 20/70 (29%) 17/70 (24%) 10/70 (14%) | 14/70 (20%) 13/70 (19%) 15/70 (21%) 11/70 (16%) |
|ADJUSTED (b) | 48.3% 44.5% 40.6% 23.7% | 40.9% 29.7% 39.8% 29.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 1/10 (10%) 1/10 (10%) | 1/9 (11%) 1/10 (10%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 13/33 (39%) 9/32 (28%) 12/36 (33%) 8/39 (21%) | 10/29 (34%) 11/41 (27%) 10/32 (31%) 7/32 (22%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 399 450 (I) 451 (I) | 451 (I) 450 (I) 655 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005N** P=0.515 P=0.286N P=0.013N* | P=0.364N P=0.184N P=0.545N P=0.242N |
|INCIDENTAL TUMOR | P=0.016N* P=0.526N P=0.339N P=0.029N* | P=0.254N P=0.301N P=0.583N P=0.274N |
|LOGISTIC REGRESSION | P=0.015N* P=0.552 P=0.357N P=0.022N* | P=0.267N P=0.354N P=0.574 P=0.251N |
|COCHRAN-ARMITAGE | P=0.015N* | P=0.300N |
|FISHER EXACT | P=0.574N P=0.351N P=0.031N* | P=0.500N P=0.500 P=0.330N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/70 (14%) 13/70 (19%) 14/70 (20%) 7/70 (10%) | 8/70 (11%) 6/70 (9%) 10/70 (14%) 9/70 (13%) |
|ADJUSTED (b) | 23.2% 29.6% 30.3% 14.6% | 21.8% 13.4% 24.5% 22.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 1/10 (10%) 1/10 (10%) | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/33 (9%) 4/32 (13%) 6/36 (17%) 1/39 (3%) | 4/29 (14%) 3/41 (7%) 4/32 (13%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 540 452 (I) 445 451 (I) | 452 (I) 553 448 542 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097N P=0.288 P=0.287 P=0.257N | P=0.331 P=0.231N P=0.476 P=0.592 |
|INCIDENTAL TUMOR | P=0.352N P=0.410 P=0.174 P=0.563N | P=0.477 P=0.508N P=0.392 P=0.533 |
|LOGISTIC REGRESSION | P=0.278N P=0.486 P=0.197 P=0.443N | P=0.314 P=0.471N P=0.422 P=0.461 |
|COCHRAN-ARMITAGE | P=0.137N | P=0.346 |
|FISHER EXACT | P=0.324 P=0.251 P=0.303N | P=0.390N P=0.401 P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/70 (37%) 28/70 (40%) 27/70 (39%) 14/70 (20%) | 19/70 (27%) 18/70 (26%) 21/70 (30%) 17/70 (24%) |
|ADJUSTED (b) | 57.8% 57.5% 56.6% 30.3% | 49.2% 39.5% 51.5% 41.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 2/10 (20%) 1/10 (10%) | 2/9 (22%) 1/10 (10%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 15/33 (45%) 12/32 (38%) 16/36 (44%) 8/39 (21%) | 11/29 (38%) 14/41 (34%) 13/32 (41%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 399 445 451 (I) | 451 (I) 450 (I) 448 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** P=0.369 P=0.549N P=0.010N** | P=0.476N P=0.164N P=0.561 P=0.302N |
|INCIDENTAL TUMOR | P=0.009N** P=0.514 P=0.465 P=0.032N* | P=0.319N P=0.411N P=0.462 P=0.364N |
|LOGISTIC REGRESSION | P=0.006N** P=0.527 P=0.451 P=0.022N* | P=0.384N P=0.353N P=0.480 P=0.327N |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.401N |
|FISHER EXACT | P=0.431 P=0.500 P=0.019N* | P=0.500N P=0.426 P=0.423N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/70 (37%) 28/70 (40%) 27/70 (39%) 14/70 (20%) | 19/70 (27%) 18/70 (26%) 21/70 (30%) 17/70 (24%) |
|ADJUSTED (b) | 57.8% 57.5% 56.6% 30.3% | 49.2% 39.5% 51.5% 41.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 2/10 (20%) 1/10 (10%) | 2/9 (22%) 1/10 (10%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 15/33 (45%) 12/32 (38%) 16/36 (44%) 8/39 (21%) | 11/29 (38%) 14/41 (34%) 13/32 (41%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 399 445 451 (I) | 451 (I) 450 (I) 448 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** P=0.369 P=0.549N P=0.010N** | P=0.476N P=0.164N P=0.561 P=0.302N |
|INCIDENTAL TUMOR | P=0.009N** P=0.514 P=0.465 P=0.032N* | P=0.319N P=0.411N P=0.462 P=0.364N |
|LOGISTIC REGRESSION | P=0.006N** P=0.527 P=0.451 P=0.022N* | P=0.384N P=0.353N P=0.480 P=0.327N |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.401N |
|FISHER EXACT | P=0.431 P=0.500 P=0.019N* | P=0.500N P=0.426 P=0.423N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/70 (10%) 7/70 (10%) 8/70 (11%) 4/70 (6%) | 2/70 (3%) 5/70 (7%) 4/70 (6%) 3/70 (4%) |
|ADJUSTED (b) | 17.0% 19.0% 21.6% 9.3% | 6.9% 11.9% 11.3% 8.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/33 (6%) 3/32 (9%) 7/36 (19%) 3/39 (8%) | 2/29 (7%) 4/41 (10%) 3/32 (9%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 619 602 725 451 (I) | 729 (T) 719 465 681 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125N P=0.547 P=0.538 P=0.215N | P=0.549N P=0.373 P=0.376 P=0.548 |
|INCIDENTAL TUMOR | P=0.216N P=0.557N P=0.454 P=0.329N | P=0.487N P=0.294 P=0.358 P=0.562 |
|LOGISTIC REGRESSION | P=0.158N P=0.524N P=0.491 P=0.248N | P=0.499N P=0.326 P=0.357 P=0.553 |
|COCHRAN-ARMITAGE | P=0.195N | P=0.512N |
|FISHER EXACT | P=0.610N P=0.500 P=0.266N | P=0.221 P=0.340 P=0.500 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 3/70 (4%) 1/70 (1%) 6/70 (9%) | 0/70 (0%) 0/70 (0%) 2/70 (3%) 1/70 (1%) |
|ADJUSTED (b) | 13.4% 8.5% 2.5% 14.3% | 0.0% 0.0% 4.6% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/33 (9%) 2/32 (6%) 0/36 (0%) 4/39 (10%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 640 654 701 656 | --- --- 465 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.337 P=0.383N P=0.101N P=0.591 | P=0.356 (e) P=0.251 P=0.520 |
|INCIDENTAL TUMOR | P=0.231 P=0.341N P=0.126N P=0.484 | P=0.428 (e) P=0.236 P=0.520 |
|LOGISTIC REGRESSION | P=0.188 P=0.384N P=0.078N P=0.531 | P=0.359 (e) P=0.238 P=0.520 |
|COCHRAN-ARMITAGE | P=0.244 | P=0.357 |
|FISHER EXACT | P=0.359N P=0.104N P=0.500 | (e) P=0.248 P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/70 (13%) 10/70 (14%) 9/70 (13%) 10/70 (14%) | 2/70 (3%) 5/70 (7%) 5/70 (7%) 4/70 (6%) |
|ADJUSTED (b) | 22.4% 26.4% 23.5% 23.1% | 6.9% 11.9% 13.5% 11.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 4/33 (12%) 5/32 (16%) 7/36 (19%) 7/39 (18%) | 2/29 (7%) 4/41 (10%) 3/32 (9%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 619 602 701 451 (I) | 729 (T) 719 465 681 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.456N P=0.440 P=0.555N P=0.579N | P=0.469 P=0.373 P=0.255 P=0.386 |
|INCIDENTAL TUMOR | P=0.477 P=0.548 P=0.550 P=0.462 | P=0.549 P=0.294 P=0.247 P=0.398 |
|LOGISTIC REGRESSION | P=0.555N P=0.587 P=0.593 P=0.532 | P=0.520 P=0.326 P=0.233 P=0.392 |
|COCHRAN-ARMITAGE | P=0.497 | P=0.505 |
|FISHER EXACT | P=0.500 P=0.599N P=0.500 | P=0.221 P=0.221 P=0.340 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/68 (0%) 1/67 (1%) 0/68 (0%) 0/65 (0%) | 4/68 (6%) 3/70 (4%) 5/68 (7%) 2/67 (3%) |
|ADJUSTED (b) | 0.0% 2.6% 0.0% 0.0% | 12.5% 7.1% 16.1% 6.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/30 (0%) 0/35 (0%) 0/34 (0%) | 3/29 (10%) 2/41 (5%) 5/31 (16%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | --- 659 --- --- | 599 719 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.533N P=0.485 (e) (e) | P=0.363N P=0.340N P=0.539 P=0.307N |
|INCIDENTAL TUMOR | P=0.576N P=0.477 (e) (e) | P=0.388N P=0.448N P=0.452 P=0.403N |
|LOGISTIC REGRESSION | P=0.551N P=0.492 (e) (e) | P=0.318N P=0.416N P=0.534 P=0.308N |
|COCHRAN-ARMITAGE | P=0.553N | P=0.328N |
|FISHER EXACT | P=0.496 (e) (e) | P=0.484N P=0.500 P=0.347N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) 0/70 (0%) 0/70 (0%) | 1/70 (1%) 1/70 (1%) 1/70 (1%) 3/70 (4%) |
|ADJUSTED (b) | 0.0% 5.3% 0.0% 0.0% | 3.4% 2.1% 1.7% 6.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 1/32 (3%) 0/36 (0%) 0/39 (0%) | 1/29 (3%) 0/41 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 584 --- --- | 729 (T) 581 424 477 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.307N P=0.234 (e) (e) | P=0.159 P=0.709N P=0.743N P=0.338 |
|INCIDENTAL TUMOR | P=0.377N P=0.280 (e) (e) | P=0.147 P=0.748 P=0.747 P=0.296 |
|LOGISTIC REGRESSION | P=0.322N P=0.235 (e) (e) | P=0.156 P=0.747N P=0.762N P=0.312 |
|COCHRAN-ARMITAGE | P=0.326N | P=0.156 |
|FISHER EXACT | P=0.248 (e) (e) | P=0.752N P=0.752N P=0.310 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 0/70 (0%) 2/70 (3%) 2/70 (3%) | 0/70 (0%) 1/69 (1%) 1/70 (1%) 2/70 (3%) |
|ADJUSTED (b) | 10.0% 0.0% 5.3% 4.5% | 0.0% 2.3% 2.3% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 0/32 (0%) 1/36 (3%) 0/39 (0%) | 0/29 (0%) 0/40 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 667 --- 725 656 | --- 700 654 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.534N P=0.084N P=0.332N P=0.309N | P=0.209 P=0.535 P=0.525 P=0.270 |
|INCIDENTAL TUMOR | P=0.562 P=0.049N* P=0.492N P=0.450N | P=0.323 P=0.338 P=0.540 P=0.283 |
|LOGISTIC REGRESSION | P=0.569N P=0.070N P=0.342N P=0.326N | P=0.216 P=0.522 P=0.505 P=0.264 |
|COCHRAN-ARMITAGE | P=0.602N | P=0.210 |
|FISHER EXACT | P=0.060N P=0.340N P=0.340N | P=0.496 P=0.500 P=0.248 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 2/70 (3%) 2/70 (3%) 2/70 (3%) | 3/70 (4%) 3/70 (4%) 1/70 (1%) 3/70 (4%) |
|ADJUSTED (b) | 13.0% 6.3% 4.5% 4.9% | 8.7% 6.9% 3.1% 9.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/33 (9%) 2/32 (6%) 0/36 (0%) 1/39 (3%) | 1/29 (3%) 2/41 (5%) 1/32 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 729 (T) 478 724 | 662 581 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252N P=0.235N P=0.208N P=0.175N | P=0.567 P=0.544N P=0.277N P=0.613N |
|INCIDENTAL TUMOR | P=0.328N P=0.229N P=0.252N P=0.209N | P=0.563 P=0.585 P=0.254N P=0.586N |
|LOGISTIC REGRESSION | P=0.292N P=0.231N P=0.221N P=0.206N | P=0.602 P=0.611N P=0.283N P=0.616N |
|COCHRAN-ARMITAGE | P=0.310N | P=0.590 |
|FISHER EXACT | P=0.221N P=0.221N P=0.221N | P=0.660N P=0.310N P=0.660N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 2/70 (3%) 2/70 (3%) 2/70 (3%) | 3/70 (4%) 3/70 (4%) 1/70 (1%) 2/70 (3%) |
|ADJUSTED (b) | 10.6% 6.3% 4.5% 4.9% | 8.7% 6.9% 3.1% 6.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/33 (9%) 2/32 (6%) 0/36 (0%) 1/39 (3%) | 1/29 (3%) 2/41 (5%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 729 (T) 478 724 | 662 581 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.336N P=0.349N P=0.322N P=0.283N | P=0.436N P=0.544N P=0.277N P=0.453N |
|INCIDENTAL TUMOR | P=0.410N P=0.349N P=0.350N P=0.308N | P=0.440N P=0.585 P=0.254N P=0.421N |
|LOGISTIC REGRESSION | P=0.383N P=0.351N P=0.340N P=0.325N | P=0.405N P=0.611N P=0.283N P=0.456N |
|COCHRAN-ARMITAGE | P=0.400N | P=0.415N |
|FISHER EXACT | P=0.340N P=0.340N P=0.340N | P=0.660N P=0.310N P=0.500N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/70 (1%) 0/70 (0%) 0/70 (0%) | 0/70 (0%) 3/70 (4%) 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 3.0% 3.1% 0.0% 0.0% | 0.0% 7.3% 2.9% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/33 (3%) 1/32 (3%) 0/36 (0%) 0/39 (0%) | 0/29 (0%) 3/41 (7%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- --- | --- 729 (T) 720 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.276N P=0.755 P=0.483N P=0.467N | P=0.557N P=0.188 P=0.524 P=0.520 |
|INCIDENTAL TUMOR | P=0.276N P=0.755 P=0.483N P=0.467N | P=0.515N P=0.188 P=0.540 P=0.520 |
|LOGISTIC REGRESSION | P=0.276N P=0.755 P=0.483N P=0.467N | P=0.530N P=0.188 P=0.517 P=0.520 |
|COCHRAN-ARMITAGE | P=0.307N | P=0.534N |
|FISHER EXACT | P=0.752N P=0.500N P=0.500N | P=0.122 P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/70 (3%) 0/70 (0%) 0/70 (0%) | 0/70 (0%) 3/70 (4%) 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 3.0% 5.1% 0.0% 0.0% | 0.0% 7.3% 2.9% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/33 (3%) 1/32 (3%) 0/36 (0%) 0/39 (0%) | 0/29 (0%) 3/41 (7%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 452 (I) --- --- | --- 729 (T) 720 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.180N P=0.493 P=0.483N P=0.467N | P=0.557N P=0.188 P=0.524 P=0.520 |
|INCIDENTAL TUMOR | P=0.180N P=0.493 P=0.483N P=0.467N | P=0.515N P=0.188 P=0.540 P=0.520 |
|LOGISTIC REGRESSION | P=0.196N P=0.498 P=0.483N P=0.467N | P=0.530N P=0.188 P=0.517 P=0.520 |
|COCHRAN-ARMITAGE | P=0.198N | P=0.534N |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | P=0.122 P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/70 (0%) 3/70 (4%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | | 0.0% 6.8% 0.0% 3.1% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 0/29 (0%) 2/41 (5%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 478 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.574N P=0.170 (e) P=0.520 |
|INCIDENTAL TUMOR | | P=0.553N P=0.070 (e) P=0.520 |
|LOGISTIC REGRESSION | | P=0.550N P=0.132 (e) P=0.520 |
|COCHRAN-ARMITAGE | | P=0.554N |
|FISHER EXACT | | P=0.122 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/70 (1%) 3/70 (4%) 1/70 (1%) 2/70 (3%) |
|ADJUSTED (b) | | 3.4% 6.8% 2.3% 6.3% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 1/29 (3%) 2/41 (5%) 0/32 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 478 560 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.584 P=0.408 P=0.747N P=0.535 |
|INCIDENTAL TUMOR | | P=0.528 P=0.265 P=0.621 P=0.535 |
|LOGISTIC REGRESSION | | P=0.614 P=0.335 P=0.757N P=0.535 |
|COCHRAN-ARMITAGE | | P=0.608 |
|FISHER EXACT | | P=0.310 P=0.752N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/70 (3%) 1/70 (1%) 3/70 (4%) | 0/70 (0%) 1/70 (1%) 1/70 (1%) 2/70 (3%) |
|ADJUSTED (b) | 3.0% 5.7% 2.8% 6.5% | 0.0% 2.4% 2.9% 6.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/33 (3%) 1/32 (3%) 1/36 (3%) 2/39 (5%) | 0/29 (0%) 1/41 (2%) 0/32 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 681 729 (T) 274 (I) | --- 729 (T) 720 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.316 P=0.484 P=0.742N P=0.352 | P=0.193 P=0.569 P=0.524 P=0.260 |
|INCIDENTAL TUMOR | P=0.297 P=0.493 P=0.742N P=0.352 | P=0.230 P=0.569 P=0.540 P=0.260 |
|LOGISTIC REGRESSION | P=0.268 P=0.477 P=0.742N P=0.307 | P=0.211 P=0.569 P=0.517 P=0.260 |
|COCHRAN-ARMITAGE | P=0.258 | P=0.208 |
|FISHER EXACT | P=0.500 P=0.752N P=0.310 | P=0.500 P=0.500 P=0.248 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 1/70 (1%) 4/70 (6%) 8/70 (11%) | 1/70 (1%) 2/70 (3%) 2/70 (3%) 2/70 (3%) |
|ADJUSTED (b) | 10.0% 3.1% 9.8% 18.5% | 2.9% 4.4% 5.4% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/33 (0%) 1/32 (3%) 2/36 (6%) 5/39 (13%) | 0/29 (0%) 0/41 (0%) 1/32 (3%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 667 729 (T) 452 (I) 563 | 701 553 654 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.046 * P=0.219N P=0.626N P=0.246 | P=0.501 P=0.554 P=0.535 P=0.544 |
|INCIDENTAL TUMOR | P=0.015 * P=0.169N P=0.514 P=0.117 | P=0.570 P=0.260 P=0.558 P=0.579 |
|LOGISTIC REGRESSION | P=0.027 * P=0.199N P=0.638 P=0.197 | P=0.481 P=0.524 P=0.517 P=0.537 |
|COCHRAN-ARMITAGE | P=0.022 * | P=0.506 |
|FISHER EXACT | P=0.183N P=0.641N P=0.183 | P=0.500 P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 3/70 (4%) 5/70 (7%) 11/70 (16%) | 1/70 (1%) 3/70 (4%) 3/70 (4%) 4/70 (6%) |
|ADJUSTED (b) | 12.7% 8.7% 12.5% 24.4% | 2.9% 6.7% 8.1% 11.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/33 (3%) 2/32 (6%) 3/36 (8%) 7/39 (18%) | 0/29 (0%) 1/41 (2%) 1/32 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 667 681 452 (I) 274 (I) | 701 553 654 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * P=0.408N P=0.603N P=0.146 | P=0.217 P=0.383 P=0.347 P=0.219 |
|INCIDENTAL TUMOR | P=0.010 ** P=0.357N P=0.524 P=0.066 | P=0.276 P=0.161 P=0.367 P=0.236 |
|LOGISTIC REGRESSION | P=0.015 * P=0.392N P=0.624 P=0.098 | P=0.234 P=0.337 P=0.325 P=0.215 |
|COCHRAN-ARMITAGE | P=0.012 * | P=0.226 |
|FISHER EXACT | P=0.359N P=0.628N P=0.091 | P=0.310 P=0.310 P=0.183 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 2/70 (3%) 4/70 (6%) 0/70 (0%) | 9/70 (13%) 3/70 (4%) 6/70 (9%) 6/70 (9%) |
|ADJUSTED (b) | 11.9% 5.3% 10.5% 0.0% | 25.4% 7.0% 17.4% 15.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/33 (6%) 0/32 (0%) 3/36 (8%) 0/39 (0%) | 4/29 (14%) 2/41 (5%) 4/32 (13%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 681 680 --- | 606 653 716 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.046N* P=0.249N P=0.472N P=0.030N* | P=0.565 P=0.025N* P=0.237N P=0.230N |
|INCIDENTAL TUMOR | P=0.069N P=0.199N P=0.525N P=0.046N* | P=0.465N P=0.102N P=0.251N P=0.279N |
|LOGISTIC REGRESSION | P=0.054N P=0.223N P=0.505N P=0.033N* | P=0.489N P=0.036N* P=0.237N P=0.231N |
|COCHRAN-ARMITAGE | P=0.059N | P=0.555N |
|FISHER EXACT | P=0.221N P=0.500N P=0.029N* | P=0.064N P=0.293N P=0.293N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 2/70 (3%) 4/70 (6%) 0/70 (0%) | 9/70 (13%) 3/70 (4%) 6/70 (9%) 6/70 (9%) |
|ADJUSTED (b) | 11.9% 5.3% 10.5% 0.0% | 25.4% 7.0% 17.4% 15.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/33 (6%) 0/32 (0%) 3/36 (8%) 0/39 (0%) | 4/29 (14%) 2/41 (5%) 4/32 (13%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 681 680 --- | 606 653 716 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.046N* P=0.249N P=0.472N P=0.030N* | P=0.565 P=0.025N* P=0.237N P=0.230N |
|INCIDENTAL TUMOR | P=0.069N P=0.199N P=0.525N P=0.046N* | P=0.465N P=0.102N P=0.251N P=0.279N |
|LOGISTIC REGRESSION | P=0.054N P=0.223N P=0.505N P=0.033N* | P=0.489N P=0.036N* P=0.237N P=0.231N |
|COCHRAN-ARMITAGE | P=0.059N | P=0.555N |
|FISHER EXACT | P=0.221N P=0.500N P=0.029N* | P=0.064N P=0.293N P=0.293N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 29/70 (41%) 34/70 (49%) 27/70 (39%) 22/70 (31%) | 24/70 (34%) 26/70 (37%) 24/70 (34%) 24/70 (34%) |
|ADJUSTED (b) | 62.0% 70.2% 57.9% 47.8% | 63.5% 55.0% 60.6% 57.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 2/10 (20%) 1/10 (10%) 2/10 (20%) | 1/9 (11%) 1/10 (10%) 1/10 (10%) 1/9 (11%) |
|TERMINAL (d) | 16/33 (48%) 18/32 (56%) 17/36 (47%) 16/39 (41%) | 16/29 (55%) 20/41 (49%) 17/32 (53%) 15/32 (47%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 399 445 274 (I) | 451 (I) 450 (I) 452 (I) 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011N* P=0.207 P=0.358N P=0.065N | P=0.517 P=0.227N P=0.410N P=0.401N |
|INCIDENTAL TUMOR | P=0.052N P=0.287 P=0.467N P=0.143N | P=0.509N P=0.566N P=0.561 P=0.566N |
|LOGISTIC REGRESSION | P=0.032N* P=0.269 P=0.472N P=0.108N | P=0.422N P=0.522N P=0.496N P=0.434N |
|COCHRAN-ARMITAGE | P=0.040N* | P=0.468N |
|FISHER EXACT | P=0.248 P=0.432N P=0.146N | P=0.430 P=0.571N P=0.571N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 24/70 (34%) 24/70 (34%) 22/70 (31%) 16/70 (23%) | 22/70 (31%) 14/70 (20%) 20/70 (29%) 22/70 (31%) |
|ADJUSTED (b) | 50.4% 50.4% 45.8% 33.4% | 51.6% 29.2% 44.1% 48.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 2/10 (20%) 1/10 (10%) | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 10/33 (30%) 9/32 (28%) 11/36 (31%) 8/39 (21%) | 9/29 (31%) 8/41 (20%) 8/32 (25%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 452 (I) 445 451 (I) | 452 (I) 341 424 477 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.029N* P=0.479 P=0.387N P=0.062N | P=0.232 P=0.022N* P=0.326N P=0.418N |
|INCIDENTAL TUMOR | P=0.143N P=0.474N P=0.540N P=0.173N | P=0.380 P=0.260N P=0.418N P=0.521N |
|LOGISTIC REGRESSION | P=0.120N P=0.411N P=0.485N P=0.136N | P=0.199 P=0.090N P=0.570N P=0.498 |
|COCHRAN-ARMITAGE | P=0.057N | P=0.240 |
|FISHER EXACT | P=0.571N P=0.429N P=0.095N | P=0.088N P=0.427N P=0.572N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05093 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROANILINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG | VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 36/70 (51%) 41/70 (59%) 39/70 (56%) 31/70 (44%) | 37/70 (53%) 34/70 (49%) 35/70 (50%) 37/70 (53%) |
|ADJUSTED (b) | 70.3% 80.1% 76.3% 61.5% | 78.6% 66.5% 74.1% 76.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 3/10 (30%) 3/10 (30%) 2/10 (20%) | 2/9 (22%) 1/10 (10%) 1/10 (10%) 1/9 (11%) |
|TERMINAL (d) | 18/33 (55%) 22/32 (69%) 24/36 (67%) 20/39 (51%) | 19/29 (66%) 24/41 (59%) 20/32 (63%) 21/32 (66%) |
|FIRST INCIDENCE (DAYS) | 450 (I) 399 445 274 (I) | 451 (I) 341 424 450 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.023N* P=0.209 P=0.483 P=0.121N | P=0.340 P=0.042N* P=0.270N P=0.349N |
|INCIDENTAL TUMOR | P=0.129N P=0.279 P=0.254 P=0.337N | P=0.486 P=0.506N P=0.463N P=0.565N |
|LOGISTIC REGRESSION | P=0.076N P=0.273 P=0.283 P=0.191N | P=0.418 P=0.282N P=0.507N P=0.565N |
|COCHRAN-ARMITAGE | P=0.086N | P=0.427 |
|FISHER EXACT | P=0.248 P=0.367 P=0.249N | P=0.368N P=0.433N P=0.567N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 273 450
Female interim sacrifices(days): 273 450
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).