TDMS Study 05096-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05096 O-CHLOROBENZALMALONONITRILE (CS-2) TIME: 05:27:08
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55118
CONT: N01-ES-38061 CAS: 2698-41-1
PATHOLOGIST: R. RENNE S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05096 O-CHLOROBENZALMALONONITRILE (CS-2) TIME: 05:27:08
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55118
CONT: N01-ES-38061 CAS: 2698-41-1
PATHOLOGIST: R. RENNE S. EUSTIS
O-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 749 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 43 196 440 483 609 665 685 693 707 720 |
| 737 737 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.75 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 374 513 527 562 585 608 657 737 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5 MG/ M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 92 381 511 545 562 571 599 693 710 713 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 749 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 749 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 96.0 96.0 96.0 92.0 92.0 92.0 88.0 76.0 |
| | |
| | |
|0.75 MG/M3 | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 86.0 84.0 |
| | |
| | |
|1.5 MG/ M3 | 100.0 98.0 98.0 98.0 96.0 96.0 92.0 86.0 86.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.75 MG/M3 1.5 MG/ M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 84.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.746N P=0.475N P=0.837N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 559.6 570.4 537.7 |
|NATURAL DEATHS (C) | (66.1) (38.0) (59.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 703.5 720.4 706.7 |
|(STANDARD ERROR) | (19.2) (11.0) (16.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 748 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 263 381 451 464 552 615 625 668 679 692 |
| 693 709 709 715 723 727 740 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.75 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 52 267 639 658 700 700 709 709 729 735 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5 MG/ M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 215 543 615 693 697 709 709 709 736 745 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 748 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 748 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 96.0 92.0 92.0 90.0 86.0 66.0 |
| | |
| | |
|0.75 MG/M3 | 98.0 98.0 96.0 96.0 96.0 96.0 96.0 96.0 92.0 80.0 |
| | |
| | |
|1.5 MG/ M3 | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 96.0 94.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.75 MG/M3 1.5 MG/ M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 80.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.109N P=0.157N P=0.147N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 612.1 589.8 637.1 |
|NATURAL DEATHS (C) | (34.2) (74.1) (50.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 701.8 716.4 725.8 |
|(STANDARD ERROR) | (14.7) (16.8) (11.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-CHLOROBENZALMALONONITRILE (CS-2)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.75 MG/M3 = 2
1.5 MG/ M3 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 + 1 1 3 2
|
|
| 1 3 1 23 2
97.5 +
|
| 1 3 1 32 2
|
95.0 +
|
| 1 1 3 2 3 2
|
P 92.5 +
E | 1 3 2 2 1
R |
C |
E 90.0 + 33 2 1 1
N |
T |
| 3 32 21 1
S 87.5 +
U |
R | 3 2 11 2
V |
I 85.0 +
V |
A | 1 13 22
L |
82.5 +
| 1 1
|
|
80.0 + 31 13
|
|
|
77.5 +
|
| 11
|
75.0 +
|
---+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+--
0 7 14 21 28 35 42 49 56 63 70 77 84 91 98 105 112
WEEK
NOTE: 6 obs hidden.
O-CHLOROBENZALMALONONITRILE (CS-2)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.75 MG/M3 = 2
1.5 MG/ M3 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 3 12 1 3
| 2 1 1 3 3 2
95 +
| 1 1 3 2 2 3
P | 1 1 2 32
E |
R 90 + 1 1 3 3
C |
E | 1 1 2 2
N | 1 1
T 85 +
| 11 2 23
S | 1 1 33
U |
R 80 + 2 2
V |
I | 1 1
V |
A 75 +
L | 11
| 11
|
70 +
|
| 1 1
| 11
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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