TDMS Study 05097-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) ALPHA-CHLOROACETOPHENONE NTP Experiment-Test: 05097-01 Report: PEIRPT05 Study Type: CHRONIC Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 Facility: Battelle Northwest Chemical CAS #: 532-27-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund 22 28 22 Dead 5 2 4 Survivors Terminal Sacrifice 23 20 24 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (47) (28) (41) Leiomyoma 1 (2%) Intestine Large, Colon (48) (28) (48) Intestine Small, Ileum (46) (27) (45) Intestine Small, Jejunum (48) (28) (46) Liver (49) (41) (49) Mesentery (6) (2) (2) Sarcoma 1 (17%) Pancreas (49) (30) (47) Acinus, Adenoma 1 (2%) Salivary Glands (49) (29) (49) Stomach, Forestomach (47) (49) (49) Stomach, Glandular (49) (50) (49) Tongue (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (30) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (49) (50) (48) Adenoma 5 (10%) 4 (8%) 4 (8%) Carcinoma 1 (2%) Sarcoma, Metastatic, Uterus 1 (2%) Adrenal Gland, Medulla (49) (50) (48) Ganglioneuroma 1 (2%) Pheochromocytoma Benign 3 (6%) 4 (8%) 3 (6%) Bilateral, Pheochromocytoma Benign 2 (4%) Islets, Pancreatic (48) (29) (46) Page 2 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Adenoma 2 (4%) 1 (2%) Carcinoma 2 (4%) Parathyroid Gland (32) (22) (38) Adenoma 1 (3%) Pituitary Gland (49) (48) (49) Pars Distalis, Adenoma 27 (55%) 40 (83%) 30 (61%) Pars Distalis, Carcinoma 3 (6%) 5 (10%) Thyroid Gland (47) (30) (45) Bilateral, C-Cell, Adenoma 1 (2%) C-Cell, Adenoma 1 (2%) 3 (10%) 6 (13%) Follicular Cell, Adenocarcinoma 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (45) (33) (42) Adenoma 5 (11%) 2 (6%) 2 (5%) Adenoma, Multiple 1 (2%) Carcinoma 1 (3%) 1 (2%) Ovary (49) (31) (49) Adenoma 1 (2%) Granulosa Cell Tumor Malignant 1 (2%) Granulosa-Theca Tumor Malignant 1 (2%) Granulosa-Theca Tumor Benign 1 (2%) Uterus (49) (33) (48) Adenocarcinoma 1 (2%) Adenoma 2 (4%) Deciduoma Benign 1 (2%) Fibroma 1 (2%) Polyp Stromal 6 (12%) 6 (18%) 5 (10%) Sarcoma Stromal 1 (3%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (30) (47) Lymph Node (49) (31) (49) Lymph Node, Bronchial (44) (26) (41) Lymph Node, Mandibular (46) (30) (47) Spleen (49) (35) (49) Thymus (38) (24) (46) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (48) (50) (50) Adenocarcinoma 2 (4%) 2 (4%) 1 (2%) Adenoma 2 (4%) 1 (2%) Fibroadenoma 11 (23%) 15 (30%) 21 (42%) Fibroadenoma, Multiple 1 (2%) 4 (8%) 2 (4%) Skin (49) (27) (47) Keratoacanthoma 1 (2%) 1 (2%) Squamous Cell Papilloma 1 (2%) Thoracic, Subcutaneous Tissue, Ventral, Leukemia Mononuclear 4 (8%) 1 (4%) 4 (9%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) Schwannoma Malignant 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (30) (50) Carcinoma, Metastatic, Pituitary Gland 3 (6%) 5 (10%) Glioma Benign 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (40) (49) Alveolar/Bronchiolar Adenoma 1 (2%) 1 (3%) Alveolar/Bronchiolar Carcinoma 1 (2%) Carcinoma, Metastatic, Adrenal Gland 1 (2%) Neoplasm NOS, Metastatic, Uncertain Primary Site 1 (3%) Sarcoma, Metastatic, Uterus 1 (2%) Mediastinum, Hemangioma 1 (2%) Mediastinum, Sarcoma 1 (2%) Nose (48) (50) (49) Fibrosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (49) (2) (48) Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (37) (49) Capsule, Sarcoma, Metastatic, Uterus 1 (2%) Renal Tubule, Adenoma 1 (3%) Urinary Bladder (48) (31) (48) Transitional Epithelium, Papilloma 1 (2%) 1 (3%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Leukemia Mononuclear 27 (54%) 23 (46%) 20 (40%) Lymphoma Malignant Histiocytic 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 45 50 48 Total Primary Neoplasms 113 110 120 Total Animals with Benign Neoplasms 39 47 43 Total Benign Neoplasms 74 83 84 Total Animals with Malignant Neoplasms 32 26 29 Total Malignant Neoplasms 39 27 36 Total Animals with Metastatic Neoplasms 3 1 7 Total Metastatic Neoplasm 3 1 9 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund 26 22 24 Dead 10 6 9 Survivors Terminal Sacrifice 14 22 17 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (44) (47) (46) Intestine Small, Duodenum (43) (45) (45) Adenocarcinoma 1 (2%) Intestine Small, Ileum (41) (45) (43) Intestine Small, Jejunum (43) (44) (40) Liver (49) (50) (50) Adenoma 1 (2%) Mesentery (2) (3) (3) Pancreas (47) (50) (49) Acinus, Adenoma 1 (2%) Pharynx (3) Palate, Squamous Cell Papilloma 3 (100%) Salivary Glands (46) (49) (49) Stomach, Forestomach (46) (49) (49) Stomach, Glandular (48) (49) (49) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (47) (49) (50) Adenoma 1 (2%) 2 (4%) 1 (2%) Adrenal Gland, Medulla (46) (49) (50) Pheochromocytoma Malignant 2 (4%) 1 (2%) 2 (4%) Pheochromocytoma Benign 11 (24%) 10 (20%) 16 (32%) Bilateral, Pheochromocytoma Benign 3 (7%) 5 (10%) 4 (8%) Islets, Pancreatic (47) (50) (48) Adenoma 3 (6%) 6 (12%) 1 (2%) Adenoma, Multiple 1 (2%) Page 7 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Carcinoma 1 (2%) Parathyroid Gland (35) (33) (44) Adenoma 2 (6%) 1 (2%) Pituitary Gland (47) (50) (48) Pars Distalis, Adenoma 31 (66%) 35 (70%) 32 (67%) Pars Distalis, Carcinoma 1 (2%) 1 (2%) Thyroid Gland (45) (46) (48) C-Cell, Adenoma 5 (11%) 5 (11%) 2 (4%) C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%) Follicular Cell, Adenocarcinoma 2 (4%) 1 (2%) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (2) Chordoma 1 (50%) Sarcoma 1 (50%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (40) (36) (39) Penis (1) Preputial Gland (45) (48) (50) Adenoma 2 (4%) 6 (13%) 5 (10%) Carcinoma 1 (2%) Squamous Cell Carcinoma 1 (2%) Prostate (49) (49) (47) Adenoma 1 (2%) Testes (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 18 (36%) 21 (42%) 20 (40%) Interstitial Cell, Adenoma 11 (22%) 10 (20%) 7 (14%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (46) (49) (50) Lymph Node (48) (50) (49) Lymph Node, Bronchial (44) (48) (46) Sarcoma, Metastatic 1 (2%) Lymph Node, Mandibular (45) (43) (45) Spleen (48) (49) (49) Thymus (33) (38) (41) Thymoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (23) (20) (23) Adenocarcinoma 1 (5%) Adenoma 1 (4%) Fibroadenoma 1 (5%) Skin (46) (49) (47) Basal Cell Adenoma 1 (2%) Basal Cell Carcinoma 1 (2%) 1 (2%) Keratoacanthoma 4 (9%) 2 (4%) 4 (9%) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Neurofibrosarcoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (47) (50) (50) Femur, Osteosarcoma 1 (2%) Skeletal Muscle (1) Hemangioma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (50) (50) Astrocytoma Malignant 1 (2%) Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%) Glioma Benign 1 (2%) Glioma Malignant 1 (2%) Granular Cell Tumor Benign 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Neoplasm NOS, Metastatic, Tissue NOS 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (2%) Sarcoma, Metastatic, Eye 1 (2%) Sarcoma, Metastatic, Tissue NOS 1 (2%) Squamous Cell Carcinoma, Metastatic, Skin 1 (2%) Page 9 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Nose (46) (50) (49) Carcinoma, Metastatic, Skin 1 (2%) Trachea (46) (48) (49) Carcinoma, Metastatic, Thyroid Gland 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (2) (50) Sarcoma 1 (50%) Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (49) (50) Lipoma 1 (2%) Renal Tubule, Adenoma 1 (2%) 1 (2%) Urinary Bladder (49) (50) (49) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Leukemia Mononuclear 29 (58%) 26 (52%) 27 (54%) Mesothelioma Benign 2 (4%) 2 (4%) Mesothelioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 48 50 49 Total Primary Neoplasms 145 151 138 Total Animals with Benign Neoplasms 44 48 48 Total Benign Neoplasms 102 113 102 Total Animals with Malignant Neoplasms 34 35 30 Total Malignant Neoplasms 43 38 36 Total Animals with Metastatic Neoplasms 4 4 2 Total Metastatic Neoplasm 7 5 2 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 65521-65521/65521 --multipart-boundary--