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TDMS Study 05098-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           P-NITROPHENOL


NTP Experiment-Test: 05098-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37




       Facility:  Hazleton, Maryland

       Chemical CAS #:  100-02-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           27           22           25                                     
    Natural Death                                      5            7            5            7                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           26           33           27                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (53)         (56)         (54)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Large, Cecum                             (57)         (56)         (59)         (56)                                   
   Intestine Large, Colon                             (56)         (56)         (58)         (57)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Duodenum                          (58)         (56)         (57)         (53)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (57)         (57)         (60)         (56)                                   
      Polyp Adenomatous                                1 (2%)       1 (2%)                                                          
   Intestine Small, Jejunum                           (55)         (54)         (56)         (55)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Sarcoma, Metastatic                                                                     1 (2%)                                
   Mesentery                                          (1)                       (2)          (1)                                    
   Pancreas                                           (60)         (57)         (60)         (60)                                   
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                                                 2 (3%)                                
   Stomach, Glandular                                 (60)         (59)         (60)         (60)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Sarcoma                                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (60)         (60)                                   
   Adrenal Gland, Medulla                             (59)         (58)         (59)         (60)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Parathyroid Gland                                  (34)         (30)         (30)         (25)                                   
   Pituitary Gland                                    (54)         (56)         (54)         (56)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
   Thyroid Gland                                      (58)         (58)         (56)         (59)                                   
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)          (1)                                    
      Fibrosarcoma                                                               1 (100%)                                           
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (60)         (57)         (60)         (59)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                                  1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Teratoma NOS                                     1 (2%)                                                                       
      Thecoma Benign                                   1 (2%)                                                                       
      Thecoma Malignant                                                          1 (2%)                                             
   Uterus                                             (60)         (58)         (60)         (59)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Leiomyoma                                                                               1 (2%)                                
      Leiomyosarcoma                                                             1 (2%)       1 (2%)                                
      Polyp Stromal                                    4 (7%)       2 (3%)       6 (10%)      1 (2%)                                
      Sarcoma Stromal                                  1 (2%)       2 (3%)       1 (2%)       3 (5%)                                
      Schwannoma Malignant                                                                    2 (3%)                                
      Cervix, Fibroma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (58)         (60)                                   
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
   Lymph Node, Mandibular                             (57)         (60)         (60)         (60)                                   
   Lymph Node, Mesenteric                             (60)         (57)         (59)         (58)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
                                                             Page   3                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (47)         (49)         (42)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (43)         (44)         (42)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Other, Trichoepithelioma                                                   1 (2%)                                             
   Skin, Site of Application-No Mass                  (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     7 (12%)      7 (12%)      8 (13%)      6 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   4 (7%)                    2 (3%)       5 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   2 (3%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Nose                                               (60)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                                                           
      Fibrosarcoma                                     1 (50%)                                                                      
   Harderian Gland                                                 (1)                       (2)                                    
      Adenoma                                                       1 (100%)                  2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
   Urinary Bladder                                    (57)         (54)         (56)         (57)                                   
                                                             Page   4                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Lymphocytic                             1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                   2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Lymphoma Malignant Lymphocytic                   2 (3%)                    1 (2%)                                             
      Lymphoma Malignant Mixed                                      1 (2%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell                                   2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            25          16          28          26                                       
     Total Primary Neoplasms                           32          22          36          34                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          10          15          14                                       
     Total Benign Neoplasms                            17          13          17          16                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13           8          16          17                                       
     Total Malignant Neoplasms                         14           9          19          18                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                  1                                       
     Total Metastatic Neoplasm                                                              1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Accidently Killed                                  4            1                         3                                     
    Moribund Sacrifice                                22           34           23           21                                     
    Natural Death                                      5            8           11           12                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                      1                                     
    Terminal Sacrifice                                28           17           26           23                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (51)         (47)         (50)         (48)                                   
   Intestine Large, Colon                             (55)         (54)         (53)         (54)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Large, Rectum                            (54)         (51)         (51)         (53)                                   
      Cystadenoma                                                   1 (2%)                                                          
   Intestine Small, Ileum                             (56)         (55)         (53)         (55)                                   
   Intestine Small, Jejunum                           (56)         (51)         (51)         (51)                                   
   Liver                                              (60)         (59)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)       3 (5%)       5 (8%)       1 (2%)                                
   Mesentery                                          (2)          (2)          (1)                                                 
      Hemangiosarcoma                                  1 (50%)                                                                      
   Pancreas                                           (60)         (58)         (60)         (60)                                   
   Salivary Glands                                    (60)         (58)         (60)         (60)                                   
      Carcinoma                                        1 (2%)                                                                       
   Stomach                                            (60)         (59)         (60)         (60)                                   
   Stomach, Forestomach                               (59)         (58)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (58)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (58)         (60)         (60)                                   
      Capsule, Adenoma                                 1 (2%)                                                                       
   Adrenal Gland, Cortex                              (60)         (58)         (59)         (59)                                   
      Adenoma                                          4 (7%)       6 (10%)      6 (10%)      5 (8%)                                
      Adenoma, Multiple                                                                       1 (2%)                                
      Bilateral, Adenoma                                            1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (58)         (60)         (59)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (59)         (56)         (58)         (59)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (54)         (54)         (50)         (52)                                   
      Pars Distalis, Carcinoma                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)          (3)                                                 
      Lipoma                                           1 (50%)                   3 (100%)                                           
      Sarcoma                                          1 (50%)      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (58)         (60)         (59)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Prostate                                           (56)         (54)         (54)         (47)                                   
      Carcinoma                                                                  1 (2%)                                             
   Testes                                             (59)         (58)         (59)         (59)                                   
      Embryonal Carcinoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (58)         (59)         (59)                                   
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Mediastinal, Carcinoma, Metastatic                                         1 (2%)                                             
   Lymph Node, Mandibular                             (56)         (57)         (60)         (60)                                   
   Lymph Node, Mesenteric                             (57)         (58)         (60)         (58)                                   
   Spleen                                             (60)         (58)         (60)         (60)                                   
   Thymus                                             (46)         (45)         (43)         (40)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Site of Application-Mass, Keratoacanthoma                     1 (2%)                                                          
      Site of Application-Mass, Papilloma                                                     1 (2%)                                
      Tail, Hemangiosarcoma                                                      1 (2%)                                             
   Skin, Site of Application-No Mass                  (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
      Carcinoma, Metastatic                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (58)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     4 (7%)       9 (16%)     12 (20%)      5 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (3%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   5 (8%)       8 (14%)      6 (10%)      6 (10%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                    1 (2%)                                
   Nose                                               (60)         (58)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (1)          (3)                                    
   Harderian Gland                                                 (1)          (2)                                                 
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
   Urinary Bladder                                    (57)         (55)         (57)         (59)                                   
      Carcinoma                                                                               1 (2%)                                
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia                                                                   1 (2%)                                             
      Lymphoma Malignant Histiocytic                                2 (3%)       2 (3%)                                             
      Lymphoma Malignant Lymphocytic                   2 (3%)                    1 (2%)       1 (2%)                                
      Lymphoma Malignant Mixed                         1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05098-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            20          33          33          21                                       
     Total Primary Neoplasms                           24          40          45          29                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          23          22          12                                       
     Total Benign Neoplasms                            13          25          27          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               9          13          14          13                                       
     Total Malignant Neoplasms                         11          15          18          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1           1                                       
     Total Metastatic Neoplasm                                                  1           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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