Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/886

TDMS Study 05098-01 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Hazelton, MD                                              DATE: 09/13/94   
EXP: 05098                      P-NITROPHENOL                  TIME: 14:12:51   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DERMAL,SOLUTION             NTP C#: 55992B   
CONT: NO1ES45040                                               CAS: 100-02-7    
PATHOLOGIST: R. CARDY                        S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Hazelton, MD                                              DATE: 09/13/94  
EXP: 05098                      P-NITROPHENOL                  TIME: 14:12:51  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DERMAL,SOLUTION             NTP C#: 55992B  
CONT: NO1ES45040                                               CAS: 100-02-7   
PATHOLOGIST: R. CARDY                        S. EUSTIS                         

                                   P-NITROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 552 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0MG/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 27     CENSORED DEATHS 4    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      222   397   409   412   419   423   475   485   486   486                 |
 |      486   492   493   508   510   510   510   512   514   517                 |
 |      519   520   521   530   532   536   549                                   |
 |  CENSORED DEATHS                                                               |
 |      126   354   420   421                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 40MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 42     CENSORED DEATHS 1    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      121   290   292   304   332   397   420   438   442   442                 |
 |      443   447   449   463   470   470   475   482   486   486                 |
 |      486   486   490   493   493   497   503   503   508   512                 |
 |      514   514   524   526   528   528   542   545   545   547                 |
 |      549   549                                                                 |
 |  CENSORED DEATHS                                                               |
 |      53                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 80MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      121   293   325   362   383   421   423   435   437   442                 |
 |      450   452   454   458   464   475   493   500   510   510                 |
 |      510   512   512   514   517   518   519   520   531   533                 |
 |      536   545   547   550                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   P-NITROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 552 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 160MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 33     CENSORED DEATHS 3    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      195   268   317   385   395   412   427   437   441   442                 |
 |      445   447   463   474   478   478   480   482   484   484                 |
 |      486   486   487   493   504   507   509   513   514   517                 |
 |      528   528   542                                                           |
 |  CENSORED DEATHS                                                               |
 |      400   420   471                                                           |
 |                                                                                |
 ==================================================================================

                                   P-NITROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 552 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   552 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0MG/KG     |   100.0 100.0  98.3  98.3  89.6  86.0  53.8  52.0  52.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 |40MG/KG    |   100.0  98.3  98.3  91.5  88.1  69.5  33.9  28.8  28.8  28.8      |
 |           |                                                                    |
 |           |                                                                    |
 |80MG/KG    |   100.0  98.3  98.3  93.3  88.3  73.3  46.7  43.3  43.3  43.3      |
 |           |                                                                    |
 |           |                                                                    |
 |160MG/KG   |   100.0 100.0  96.7  95.0  90.0  65.5  42.5  42.5  42.5  42.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0MG/KG       40MG/KG      80MG/KG      160MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.0%        28.8%        43.3%        42.5%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.498      P=0.013      P=0.387      P=0.186  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       480.5        465.0        463.9        456.0    |
 |NATURAL DEATHS (C)      |       (12.8)       (13.3)       (15.0)       (13.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       505.0        482.8        502.1        493.1    |
 |(STANDARD ERROR)        |       (10.3)       (12.8)       (10.2)       ( 9.5)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   P-NITROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 552 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0MG/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      120   295   370   373   438   442   447   448   450   463                 |
 |      472   475   475   483   485   493   493   497   505   510                 |
 |      511   512   512   520   528                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 40MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      263   266   361   367   375   440   442   449   450   450                 |
 |      456   473   477   478   482   482   486   492   497   497                 |
 |      497   497   497   498   500   500   514   527   529   530                 |
 |      532   542   545   549                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 80MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      349   401   427   442   442   446   458   458   463   464                 |
 |      470   475   477   493   503   504   507   507   510   510                 |
 |      521   532   532   538   545   545   548                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   P-NITROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 552 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 160MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 32     CENSORED DEATHS 1    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      84    405   411   443   454   458   463   468   470   473                 |
 |      475   475   475   480   486   492   497   500   506   507                 |
 |      508   509   517   521   524   531   531   532   532   542                 |
 |      545   546                                                                 |
 |  CENSORED DEATHS                                                               |
 |      371                                                                       |
 |                                                                                |
 ==================================================================================

                                   P-NITROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 552 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   552 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0MG/KG     |   100.0  98.3  98.3  96.7  93.3  75.0  58.3  58.3  58.3  58.3      |
 |           |                                                                    |
 |           |                                                                    |
 |40MG/KG    |   100.0 100.0  96.7  95.0  91.7  73.3  45.0  43.3  43.3  43.3      |
 |           |                                                                    |
 |           |                                                                    |
 |80MG/KG    |   100.0 100.0 100.0  98.3  96.7  78.3  56.7  55.0  55.0  55.0      |
 |           |                                                                    |
 |           |                                                                    |
 |160MG/KG   |    98.3  98.3  98.3  98.3  94.9  76.3  47.5  45.8  45.8  45.8      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0MG/KG       40MG/KG      80MG/KG      160MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       58.3%        43.3%        55.0%        45.8%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.614      P=0.203      P=0.990      P=0.386  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       452.7        468.8        484.0        480.0    |
 |NATURAL DEATHS (C)      |       (17.5)       (11.9)       ( 9.2)       (14.3)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       510.6        504.9        521.4        510.6    |
 |(STANDARD ERROR)        |       ( 9.6)       ( 8.6)       ( 6.0)       ( 9.2)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           P-NITROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0MG/KG           = 1
                                                        40MG/KG          = 2
                                                        80MG/KG          = 3
                                                        160MG/KG         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

              |
              |
          100 +  1                      2            4     1
              |                         2            4     1        4   2    43            1  1
              |                                                         2 2  43      3   4
              |                                                           2    2     3   3 2  111
           90 +                                                                            2  421        1
              |                                                                                23  22    1  1
              |                                                                                    33
              |                                                                                     3 3
        P  80 +                                                                                     2 2 4   11
        E     |                                                                                       2322   1  1
        R     |                                                                                         33 4
        C     |                                                                                          3   3 3
        E  70 +                                                                                          2 22  311
        N     |
        T     |                                                                                                 31 1
              |
        S  60 +                                                                                             22     11
        U     |                                                                                              4 443 3
        R     |                                                                                              2 2    11  1
        V     |                                                                                                224 333  1
        I  50 +                                                                                                 22
        V     |                                                                                                  4  433 3
        A     |                                                                                                  2 22 4
        L     |                                                                                                       4 3
           40 +                                                                                                     2 2
              |
              |                                                                                                       2 2
              |
           30 +                                                                                                         2
              |
              |
              |
           20 +
              |
              ---+------------+------------+------------+------------+------------+------------+------------+------------+--
                 0           10           20           30           40           50           60           70           80

                                                                   WEEK

NOTE: 48 obs hidden.

                                                           P-NITROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0MG/KG           = 1
                                                        40MG/KG          = 2
                                                        80MG/KG          = 3
                                                        160MG/KG         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

              |
              |
          100 +  1               4      1                         2               3
              |                  4      1                         2      1        3  21     3 4 3
              |                                                                      211      4 3   3
              |                                                                       21           11 44
        P  90 +                                                                                    22  34
        E     |                                                                                     1 1334
        R     |                                                                                       1 1
        C     |                                                                                       2211
        E  80 +                                                                                          2 2
        N     |                                                                                          1 113 3
        T     |                                                                                             11
              |                                                                                            222 33
        S  70 +                                                                                              1 41
        U     |                                                                                                 3  3
        R     |                                                                                                 11 33
        V     |                                                                                              2 241 133
        I  60 +                                                                                                  4 1133
        V     |                                                                                                2 2 41 3 1
        A     |                                                                                                  2  2   3
        L     |
           50 +                                                                                                     4 4
              |                                                                                                     2 2
              |                                                                                                       2 2
              |                                                                                                         2
           40 +
              |
              ---+------------+------------+------------+------------+------------+------------+------------+------------+--
                 0           10           20           30           40           50           60           70           80

                                                                   WEEK

NOTE: 45 obs hidden.