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https://ntp.niehs.nih.gov/go/1730

TDMS Study 05099-07 Pathology Tables

NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96
Route: GAVAGE                                                                                                     Time: 09:24:44




       Facility:  Southern Research Institute

       Chemical CAS #:  599-79-1

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            2            5            4                                     
    Moribund Sacrifice                                12           13           14           11                                     
    Dosing Accident                                    1            1                         9                                     
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                34           33           31           26                                     
    Moribund Sacrifice                                 1                                                                            

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (59)                                   
      Diverticulum                                                               1 (2%)                                             
      Perforation                                      1 (2%)                                                                       
   Intestine Large, Colon                             (60)         (60)         (60)         (59)                                   
      Parasite Metazoan                                8 (13%)      6 (10%)      7 (12%)      5 (8%)                                
   Intestine Large, Rectum                            (60)         (60)         (59)         (59)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Parasite Metazoan                                3 (5%)       5 (8%)       5 (8%)       7 (12%)                               
   Intestine Large, Cecum                             (59)         (59)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)       1 (2%)       2 (3%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      2 (3%)       3 (5%)       7 (12%)      1 (2%)                                
      Basophilic Focus                                53 (88%)     51 (85%)     57 (95%)     45 (75%)                               
      Clear Cell Focus                                 9 (15%)      8 (13%)     11 (18%)      8 (13%)                               
      Cyst                                                                                    1 (2%)                                
      Developmental Malformation                                                 1 (2%)                                             
      Eosinophilic Focus                              13 (22%)     13 (22%)     20 (33%)     15 (25%)                               
      Granuloma                                       16 (27%)     13 (22%)      8 (13%)      4 (7%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)                    2 (3%)                                
      Hepatodiaphragmatic Nodule                       9 (15%)      9 (15%)      6 (10%)      4 (7%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Mixed Cell Focus                                10 (17%)      8 (13%)     11 (18%)      6 (10%)                               
      Bile Duct, Hyperplasia                          16 (27%)     11 (18%)      9 (15%)      4 (7%)                                
      Centrilobular, Atrophy                           4 (7%)       2 (3%)                    2 (3%)                                
      Hepatocyte, Vacuolization Cytoplasmic            4 (7%)       1 (2%)                                                          
      Kupffer Cell, Pigmentation                       3 (5%)                                                                       
      Lobules, Necrosis                                2 (3%)       2 (3%)       3 (5%)       3 (5%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (4)          (8)          (5)          (6)                                    
      Accessory Spleen                                 1 (25%)                                                                      
      Fat, Hemorrhage                                                                         1 (17%)                               
      Fat, Necrosis                                    3 (75%)      5 (63%)      5 (100%)     6 (100%)                              
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Atrophy                                         20 (33%)     19 (32%)     17 (28%)     17 (28%)                               
      Metaplasia, Hepatocyte                           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Acinar Cell, Basophilic Focus                    1 (2%)                                 3 (5%)                                
      Acinar Cell, Cytoplasmic Alteration              2 (3%)       2 (3%)       4 (7%)       4 (7%)                                
      Acinar Cell, Hyperplasia, Focal                  1 (2%)       3 (5%)       4 (7%)       1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy                                          1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Edema                                            1 (2%)                                                                       
      Erosion                                                       1 (2%)                    1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            1 (2%)                    1 (2%)       1 (2%)                                
      Mucosa, Hyperplasia                              2 (3%)       2 (3%)       1 (2%)       3 (5%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Erosion                                          2 (3%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Tongue                                             (1)          (1)          (1)                                                 
      Mucosa, Hyperplasia                              1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Aorta, Mineralization                                                                   1 (2%)                                
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  13 (22%)     13 (22%)     17 (28%)      9 (15%)                               
      Inflammation, Subacute                           1 (2%)                                 2 (3%)                                
      Mineralization                                                             2 (3%)                                             
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule               13 (22%)      9 (15%)     11 (18%)     16 (27%)                               
      Angiectasis                                                   5 (8%)       1 (2%)       2 (3%)                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Degeneration, Fatty                              5 (8%)      11 (18%)      7 (12%)      7 (12%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Diffuse                                          1 (2%)                                                          
      Hyperplasia, Focal                               7 (12%)      6 (10%)      9 (15%)      5 (8%)                                
      Hypertrophy, Focal                               6 (10%)      4 (7%)       5 (8%)       4 (7%)                                
      Necrosis                                         1 (2%)       1 (2%)                    1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       2 (3%)       2 (3%)       1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Pituitary Gland                                    (60)         (59)         (60)         (60)                                   
      Pars Distalis, Angiectasis                      13 (22%)      7 (12%)      8 (13%)     10 (17%)                               
      Pars Distalis, Cyst                             35 (58%)     31 (53%)     23 (38%)     19 (32%)                               
      Pars Distalis, Hyperplasia                                                              1 (2%)                                
      Pars Distalis, Hyperplasia, Focal               12 (20%)     15 (25%)     13 (22%)     14 (23%)                               
      Pars Intermedia, Angiectasis                     2 (3%)       3 (5%)       1 (2%)                                             
      Pars Intermedia, Cyst                            5 (8%)       5 (8%)       2 (3%)       2 (3%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Ultimobranchial Cyst                             3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
      C-Cell, Hyperplasia                              7 (12%)     12 (20%)     11 (18%)      8 (13%)                               
      Follicle, Cyst                                   4 (7%)                    4 (7%)                                             
      Follicular Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (60)         (60)                                   
      Ectasia                                         17 (28%)     15 (25%)     17 (28%)     18 (30%)                               
      Hyperplasia                                      1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      Inflammation, Chronic                            4 (7%)      17 (28%)     10 (17%)      6 (10%)                               
      Inflammation, Suppurative                        4 (7%)       2 (3%)       4 (7%)       8 (13%)                               
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                             7 (12%)      4 (7%)       2 (3%)       6 (10%)                               
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                                                                       
      Hydrometra                                       6 (10%)      4 (7%)       5 (8%)       2 (3%)                                
      Hyperplasia, Cystic                              3 (5%)       2 (3%)       2 (3%)                                             
      Endometrium, Hyperplasia, Focal                               1 (2%)                                                          
   Vagina                                                          (1)          (1)                                                 
      Hyperplasia                                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hypercellularity                                              4 (7%)       2 (3%)       2 (3%)                                
      Myelofibrosis                                    3 (5%)       2 (3%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
   Lymph Node                                         (12)         (9)          (9)          (7)                                    
      Iliac, Ectasia                                                                          1 (14%)                               
      Iliac, Hyperplasia, Lymphoid                                                            1 (14%)                               
      Mediastinal, Congestion                                                                 1 (14%)                               
      Mediastinal, Ectasia                                                       1 (11%)                                            
      Mediastinal, Hemorrhage                          6 (50%)      7 (78%)      3 (33%)      3 (43%)                               
      Mediastinal, Pigmentation                        7 (58%)      7 (78%)      7 (78%)      3 (43%)                               
      Pancreatic, Hemorrhage                                                     1 (11%)      1 (14%)                               
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (14%)                               
      Pancreatic, Pigmentation                                                   1 (11%)                                            
      Renal, Hemorrhage                                                                       1 (14%)                               
      Renal, Hyperplasia, Lymphoid                                                            1 (14%)                               
      Renal, Pigmentation                                                                     1 (14%)                               
   Lymph Node, Mandibular                             (60)         (58)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Ectasia                                          7 (12%)      7 (12%)      3 (5%)       1 (2%)                                
      Hemorrhage                                       3 (5%)       3 (5%)       2 (3%)       4 (7%)                                
      Hyperplasia, Lymphoid                            4 (7%)       5 (9%)       4 (7%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Pigmentation                                     8 (13%)     14 (24%)      6 (10%)      7 (12%)                               
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (60)                                   
      Ectasia                                                       1 (2%)                                                          
      Hemorrhage                                       5 (8%)       5 (8%)       3 (5%)       6 (10%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Pigmentation                                    12 (20%)      9 (15%)     12 (20%)      2 (3%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Developmental Malformation                                                 2 (3%)                                             
      Fibrosis                                         3 (5%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                29 (48%)     33 (55%)     38 (63%)     29 (48%)                               
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Pigmentation, Hemosiderin                       46 (77%)     42 (70%)     43 (72%)     47 (78%)                               
      Lymphoid Follicle, Atrophy                       1 (2%)                                 1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   1 (2%)                                                                       
   Thymus                                             (59)         (59)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       6 (10%)                               
      Cortex, Atrophy                                                                         1 (2%)                                
      Epithelial Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (58)                                   
      Ectasia                                         10 (17%)     10 (17%)     20 (33%)      4 (7%)                                
      Hyperplasia, Lobular                             4 (7%)                                                                       
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                       1 (2%)                    4 (7%)                                             
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Ulcer                                                                      2 (3%)                                             
      Subcutaneous Tissue, Inflammation, Subacute                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Calvarium, Osteopetrosis                         5 (8%)       1 (2%)       1 (2%)                                             
      Femur, Osteopetrosis                             5 (8%)       3 (5%)       2 (3%)                                             
   Skeletal Muscle                                    (2)          (1)                       (1)                                    
      Hemorrhage                                       1 (50%)                                                                      
      Inflammation, Chronic                            1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Atrophy                                                       1 (2%)                                                          
      Compression                                     10 (17%)     12 (20%)     10 (17%)      4 (7%)                                
      Hemorrhage                                       2 (3%)       2 (3%)                    1 (2%)                                
      Hydrocephalus                                    3 (5%)       3 (5%)       4 (7%)                                             
      Mineralization                                                1 (2%)                    1 (2%)                                
      Necrosis                                         1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       3 (5%)       2 (3%)       7 (12%)                               
      Edema                                            1 (2%)       1 (2%)       2 (3%)       4 (7%)                                
      Foreign Body                                     1 (2%)       2 (3%)       2 (3%)       8 (13%)                               
      Hemorrhage                                                    2 (3%)                    2 (3%)                                
      Infiltration Cellular, Histiocyte               15 (25%)     15 (25%)     11 (18%)     15 (25%)                               
      Inflammation, Subacute                           5 (8%)       5 (8%)       2 (3%)       2 (3%)                                
      Metaplasia, Osseous                                                        1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (8%)       7 (12%)      5 (8%)       3 (5%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Exudate                                          9 (15%)      9 (15%)     10 (17%)      6 (10%)                               
      Foreign Body                                     3 (5%)       6 (10%)      4 (7%)       4 (7%)                                
      Fungus                                           1 (2%)       2 (3%)                                                          
      Mucosa, Hyperplasia                              4 (7%)       2 (3%)       1 (2%)       1 (2%)                                
      Mucosa, Metaplasia, Squamous                     1 (2%)       2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (5)          (2)          (2)                                    
      Cataract                                         1 (33%)      3 (60%)      1 (50%)      2 (100%)                              
      Inflammation, Chronic                            1 (33%)                                                                      
      Inflammation, Suppurative                        1 (33%)                                                                      
      Phthisis Bulbi                                                2 (40%)      1 (50%)                                            
      Retina, Atrophy                                  2 (67%)      2 (40%)      1 (50%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Concretion                                                    9 (15%)     35 (58%)     43 (72%)                               
      Cyst                                                          1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydronephrosis                                                             3 (5%)      11 (18%)                               
      Infarct                                                                    2 (3%)       3 (5%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)       2 (3%)                                
      Mineralization                                  53 (88%)     57 (95%)     51 (85%)     50 (83%)                               
      Nephropathy                                     38 (63%)     42 (70%)     47 (78%)     54 (90%)                               
      Papilla, Necrosis                                                                       1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration                                                    1 (2%)                                
      Renal Tubule, Dilatation                         2 (3%)       2 (3%)       1 (2%)       6 (10%)                               
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)                                             
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Pigmentation                       8 (13%)      6 (10%)      2 (3%)                                             
      Transitional Epithelium, Hyperplasia             3 (5%)       7 (12%)     25 (42%)     51 (85%)                               
   Ureter                                                                       (2)          (4)                                    
      Concretion                                                                 1 (50%)      2 (50%)                               
      Mucosa, Hyperplasia                                                        2 (100%)     4 (100%)                              
   Urethra                                                                      (1)                                                 
      Mucosa, Hyperplasia                                                        1 (100%)                                           
   Urinary Bladder                                    (59)         (60)         (60)         (60)                                   
      Concretion                                                                 1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia                              2 (3%)                    4 (7%)      14 (23%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           60           60           60           60           70           

  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           16           11           16           15           13           
    Natural Death                                      1            1            2            2           10            4           
    Dosing Accident                                    1            2            4            1            2            3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           31           33           30           23           30           
    Natural Death                                                                             1                                     

  Animals Examined Microscopically                    70           60           60           60           60           70           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (59)         (60)         (59)         (59)         (70)         
      Inflammation, Suppurative                                                                                         1 (1%)      
      Perforation                                                   1 (2%)                                 1 (2%)                   
   Intestine Large, Colon                             (69)         (60)         (59)         (60)         (58)         (68)         
      Inflammation, Subacute                                                                               1 (2%)                   
      Parasite Metazoan                               10 (14%)      6 (10%)      3 (5%)       4 (7%)       6 (10%)      4 (6%)      
   Intestine Large, Rectum                            (69)         (60)         (60)         (60)         (59)         (69)         
      Parasite Metazoan                               11 (16%)      8 (13%)      5 (8%)      11 (18%)      5 (8%)       8 (12%)     
      Ulcer                                                                                                1 (2%)                   
   Intestine Large, Cecum                             (70)         (60)         (60)         (60)         (60)         (70)         
      Dilatation                                                                                           1 (2%)                   
      Edema                                                         2 (3%)                                                          
      Inflammation, Subacute                                                                               1 (2%)                   
      Parasite Metazoan                                                                       2 (3%)       1 (2%)                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Duodenum                          (70)         (60)         (60)         (60)         (60)         (69)         
      Erosion                                                                                              1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
   Intestine Small, Jejunum                           (70)         (60)         (59)         (60)         (59)         (69)         
      Erosion                                                                                 1 (2%)                                
   Intestine Small, Ileum                             (69)         (60)         (59)         (60)         (60)         (69)         
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Ulcer                                                         2 (3%)                                                          
   Liver                                              (70)         (60)         (60)         (60)         (60)         (70)         
      Angiectasis                                                                2 (3%)                                             
      Basophilic Focus                                35 (50%)     39 (65%)     37 (62%)     29 (48%)     20 (33%)     36 (51%)     
      Clear Cell Focus                                38 (54%)     23 (38%)     27 (45%)     30 (50%)     19 (32%)     22 (31%)     
      Congestion                                       1 (1%)                                                                       
      Degeneration, Cystic                             4 (6%)       2 (3%)       1 (2%)                                 1 (1%)      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Developmental Malformation                                                                           1 (2%)                   
      Eosinophilic Focus                               7 (10%)      8 (13%)     10 (17%)      7 (12%)      9 (15%)      6 (9%)      
      Granuloma                                        3 (4%)       3 (5%)                                              6 (9%)      
      Hematopoietic Cell Proliferation                              2 (3%)       3 (5%)       1 (2%)       1 (2%)       1 (1%)      
      Hepatodiaphragmatic Nodule                       5 (7%)       3 (5%)       3 (5%)       3 (5%)       3 (5%)       3 (4%)      
      Inflammation, Chronic                            1 (1%)       1 (2%)       2 (3%)                    1 (2%)       3 (4%)      
      Inflammation, Subacute                                        2 (3%)                                 2 (3%)       1 (1%)      
      Metaplasia, Osseous                                                                                               1 (1%)      
      Mixed Cell Focus                                 7 (10%)     13 (22%)      6 (10%)     13 (22%)      5 (8%)       8 (11%)     
      Bile Duct, Hyperplasia                          53 (76%)     45 (75%)     44 (73%)     44 (73%)     24 (40%)     41 (59%)     
      Centrilobular, Atrophy                           3 (4%)       4 (7%)       4 (7%)       4 (7%)                    3 (4%)      
      Centrilobular, Necrosis                                                    1 (2%)                                 1 (1%)      
      Hepatocyte, Vacuolization Cytoplasmic           10 (14%)      8 (13%)      7 (12%)      4 (7%)       2 (3%)       8 (11%)     
      Lobules, Necrosis                                                          2 (3%)       3 (5%)       2 (3%)       2 (3%)      
   Mesentery                                          (19)         (19)         (17)         (19)         (14)         (18)         
      Accessory Spleen                                              1 (5%)       1 (6%)                    1 (7%)                   
      Fibrosis                                                                                1 (5%)                                
      Fat, Hemorrhage                                  1 (5%)                    1 (6%)       1 (5%)                                
      Fat, Metaplasia, Osseous                                      1 (5%)                                                          
      Fat, Necrosis                                   15 (79%)     16 (84%)     16 (94%)     15 (79%)     11 (79%)     16 (89%)     
   Pancreas                                           (70)         (60)         (60)         (60)         (60)         (68)         
      Atrophy                                         21 (30%)     22 (37%)     33 (55%)     23 (38%)     24 (40%)     25 (37%)     
      Pigmentation                                                                            1 (2%)                                
      Acinar Cell, Basophilic Focus                    1 (1%)       3 (5%)       1 (2%)       2 (3%)                    5 (7%)      
      Acinar Cell, Cytoplasmic Alteration              1 (1%)       2 (3%)       1 (2%)       3 (5%)      15 (25%)      3 (4%)      
      Acinar Cell, Hyperplasia, Focal                 18 (26%)     20 (33%)     14 (23%)     17 (28%)     11 (18%)     16 (24%)     
   Salivary Glands                                    (70)         (60)         (59)         (60)         (60)         (70)         
      Atrophy                                                                                 1 (2%)       1 (2%)       1 (1%)      
      Inflammation, Chronic                                                      1 (2%)                                             
   Stomach, Forestomach                               (70)         (60)         (60)         (60)         (60)         (70)         
      Edema                                            1 (1%)                                 1 (2%)       4 (7%)       1 (1%)      
      Erosion                                                                                 1 (2%)       2 (3%)                   
      Inflammation, Chronic                                                                                1 (2%)                   
      Mineralization                                                                          1 (2%)       1 (2%)                   
      Perforation                                                                                          1 (2%)                   
      Ulcer                                            1 (1%)       1 (2%)       1 (2%)       1 (2%)       7 (12%)                  
      Mucosa, Hyperplasia                                           2 (3%)                                 9 (15%)                  
   Stomach, Glandular                                 (69)         (60)         (60)         (60)         (60)         (70)         
      Cyst                                                                                                 1 (2%)                   
      Erosion                                          1 (1%)                    1 (2%)       1 (2%)       2 (3%)                   
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (1%)       1 (2%)                                 1 (2%)                   
   Tongue                                             (1)                                                 (1)                       
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (70)         (60)         (60)         (60)         (60)         (70)         
      Embolus                                          1 (1%)                                                                       
      Hypertrophy                                                   1 (2%)                    1 (2%)       5 (8%)                   
      Inflammation, Chronic Active                                  1 (2%)                                 2 (3%)                   
   Heart                                              (70)         (60)         (60)         (60)         (60)         (70)         
      Cardiomyopathy                                  36 (51%)     33 (55%)     31 (52%)     33 (55%)     27 (45%)     28 (40%)     
      Foreign Body                                                                                         1 (2%)                   
      Inflammation, Subacute                                                     1 (2%)                    1 (2%)       1 (1%)      
      Mineralization                                                                                       2 (3%)                   
      Thrombosis                                                                                                        1 (1%)      
      Pericardium, Fibrosis                            1 (1%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (60)         (60)         (60)         (60)         (70)         
      Accessory Adrenal Cortical Nodule               21 (30%)     15 (25%)     22 (37%)     16 (27%)     13 (22%)     16 (23%)     
      Basophilic Focus                                                                                     1 (2%)                   
      Congestion                                       1 (1%)                    1 (2%)                                             
      Cyst                                             1 (1%)                                                           1 (1%)      
      Degeneration, Fatty                              8 (11%)      4 (7%)       6 (10%)      9 (15%)      9 (15%)      6 (9%)      
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                    2 (3%)       1 (1%)      
      Hemorrhage                                       2 (3%)                                              1 (2%)                   
      Hyperplasia, Focal                               5 (7%)       3 (5%)       8 (13%)      7 (12%)      3 (5%)       4 (6%)      
      Hypertrophy, Focal                               5 (7%)       2 (3%)       2 (3%)       3 (5%)                    3 (4%)      
      Necrosis                                                                   1 (2%)                                 2 (3%)      
   Adrenal Medulla                                    (70)         (60)         (59)         (60)         (59)         (70)         
      Hyperplasia                                     15 (21%)     14 (23%)     18 (31%)     16 (27%)     14 (24%)      9 (13%)     
   Islets, Pancreatic                                 (70)         (60)         (60)         (60)         (60)         (69)         
      Hyperplasia                                                   3 (5%)       1 (2%)                    1 (2%)       1 (1%)      
   Parathyroid Gland                                  (65)         (60)         (58)         (59)         (55)         (66)         
      Hyperplasia                                                                             1 (2%)       1 (2%)                   
   Pituitary Gland                                    (70)         (58)         (60)         (59)         (59)         (68)         
      Congestion                                       1 (1%)                                                                       
      Pars Distalis, Angiectasis                       5 (7%)       4 (7%)       1 (2%)       2 (3%)       2 (3%)       4 (6%)      
      Pars Distalis, Cyst                              8 (11%)      7 (12%)      2 (3%)       3 (5%)       9 (15%)      6 (9%)      
      Pars Distalis, Hyperplasia, Focal               18 (26%)     14 (24%)     12 (20%)     16 (27%)     13 (22%)      8 (12%)     
      Pars Intermedia, Angiectasis                                               2 (3%)       1 (2%)       1 (2%)       2 (3%)      
      Pars Intermedia, Cyst                            3 (4%)       1 (2%)       1 (2%)       1 (2%)       2 (3%)       1 (1%)      
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Nervosa, Gliosis                                                      1 (2%)                                             
   Thyroid Gland                                      (70)         (60)         (60)         (60)         (60)         (70)         
      Ultimobranchial Cyst                             1 (1%)       3 (5%)       5 (8%)       4 (7%)       1 (2%)       5 (7%)      
      C-Cell, Hyperplasia                             14 (20%)     14 (23%)     10 (17%)     11 (18%)     12 (20%)     12 (17%)     
      Follicle, Cyst                                   2 (3%)       2 (3%)       3 (5%)       1 (2%)       1 (2%)       3 (4%)      
      Follicular Cell, Hyperplasia                     1 (1%)                                              1 (2%)       2 (3%)      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hypertrophy                     3 (4%)                    3 (5%)       4 (7%)       6 (10%)      6 (9%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (60)         (60)         (60)         (60)         (70)         
      Atypia Cellular                                 25 (36%)     33 (55%)     36 (60%)     40 (67%)     34 (57%)     27 (39%)     
      Hypospermia                                     40 (57%)     33 (55%)     34 (57%)     38 (63%)     36 (60%)     34 (49%)     
   Preputial Gland                                    (70)         (60)         (60)         (60)         (60)         (70)         
      Ectasia                                         20 (29%)     12 (20%)     17 (28%)     17 (28%)     14 (23%)     14 (20%)     
      Hyperplasia                                      1 (1%)       1 (2%)                    1 (2%)       2 (3%)       1 (1%)      
      Inflammation, Chronic                           39 (56%)     24 (40%)     26 (43%)     23 (38%)     15 (25%)     40 (57%)     
      Inflammation, Suppurative                       23 (33%)     16 (27%)     17 (28%)     10 (17%)     17 (28%)     21 (30%)     
   Prostate                                           (70)         (60)         (60)         (60)         (60)         (70)         
      Corpora Amylacea                                31 (44%)     23 (38%)     30 (50%)     19 (32%)     13 (22%)     26 (37%)     
      Ectasia                                                                                 1 (2%)                    1 (1%)      
      Edema                                                                                                3 (5%)                   
      Hemorrhage                                                                              1 (2%)       3 (5%)                   
      Hyperplasia, Lymphoid                            1 (1%)                                                           2 (3%)      
      Inflammation, Suppurative                       23 (33%)     32 (53%)     22 (37%)     23 (38%)     24 (40%)     32 (46%)     
      Epithelium, Hyperplasia                          8 (11%)      8 (13%)      8 (13%)     13 (22%)      3 (5%)       4 (6%)      
   Seminal Vesicle                                    (70)         (60)         (60)         (60)         (59)         (70)         
      Dilatation                                       1 (1%)       2 (3%)       1 (2%)       1 (2%)       4 (7%)       1 (1%)      
      Hemorrhage                                                                              1 (2%)       2 (3%)                   
      Inflammation, Suppurative                                                               2 (3%)       4 (7%)                   
   Testes                                             (70)         (60)         (59)         (60)         (60)         (70)         
      Granuloma Sperm                                               1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   5 (7%)      11 (18%)      9 (15%)     11 (18%)      2 (3%)      10 (14%)     
      Seminiferous Tubule, Atrophy                                  4 (7%)       2 (3%)       2 (3%)       2 (3%)       4 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (60)         (60)         (60)         (60)         (70)         
      Hypercellularity                                 3 (4%)       3 (5%)                    3 (5%)       5 (8%)       2 (3%)      
      Myelofibrosis                                                              1 (2%)                                 2 (3%)      
   Lymph Node                                         (9)          (16)         (15)         (14)         (10)         (7)          
      Iliac, Pigmentation                                           1 (6%)                                                          
      Inguinal, Hyperplasia, Lymphoid                                                         1 (7%)                                
      Mediastinal, Congestion                                                                                           1 (14%)     
      Mediastinal, Ectasia                                                                                              1 (14%)     
      Mediastinal, Hemorrhage                          6 (67%)      7 (44%)      8 (53%)      6 (43%)      4 (40%)      4 (57%)     

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hyperplasia, Lymphoid                                         1 (7%)                    1 (10%)      1 (14%)     
      Mediastinal, Pigmentation                        5 (56%)      8 (50%)      9 (60%)      7 (50%)      5 (50%)      3 (43%)     
      Pancreatic, Hemorrhage                                        1 (6%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                             1 (6%)                                                          
      Renal, Pigmentation                                           1 (6%)                                                          
   Lymph Node, Mandibular                             (70)         (59)         (60)         (60)         (59)         (70)         
      Congestion                                                    1 (2%)                                 1 (2%)                   
      Ectasia                                          5 (7%)       7 (12%)      3 (5%)       4 (7%)                    5 (7%)      
      Hemorrhage                                       7 (10%)      4 (7%)      10 (17%)      1 (2%)       5 (8%)      10 (14%)     
      Hyperplasia, Lymphoid                            6 (9%)       5 (8%)       4 (7%)                    7 (12%)      3 (4%)      
      Hyperplasia, Plasma Cell                         1 (1%)       1 (2%)                                              2 (3%)      
      Pigmentation                                     1 (1%)       2 (3%)       3 (5%)                                 2 (3%)      
   Lymph Node, Mesenteric                             (70)         (60)         (60)         (60)         (59)         (69)         
      Ectasia                                                       2 (3%)                                                          
      Hemorrhage                                       3 (4%)       6 (10%)      2 (3%)                    5 (8%)       2 (3%)      
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)                                              1 (1%)      
      Pigmentation                                                  3 (5%)       2 (3%)                                             
   Spleen                                             (70)         (60)         (60)         (60)         (60)         (70)         
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                         8 (11%)      3 (5%)       8 (13%)      3 (5%)       2 (3%)       3 (4%)      
      Hematopoietic Cell Proliferation                16 (23%)     12 (20%)     18 (30%)     17 (28%)     25 (42%)     14 (20%)     
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Reticulum Cell                                                                          1 (2%)                   
      Metaplasia                                                    1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Pigmentation, Hemosiderin                       22 (31%)     20 (33%)     15 (25%)     15 (25%)     34 (57%)     16 (23%)     
      Lymphoid Follicle, Atrophy                                    1 (2%)                                 5 (8%)                   
   Thymus                                             (66)         (60)         (58)         (59)         (59)         (69)         
      Cyst                                                                                    1 (2%)                    1 (1%)      
      Hemorrhage                                       7 (11%)      1 (2%)                                 1 (2%)       2 (3%)      
      Cortex, Atrophy                                                                                      2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (67)         (58)         (58)         (57)         (59)         (68)         
      Hyperplasia, Cystic                             12 (18%)     17 (29%)      9 (16%)     14 (25%)     10 (17%)     10 (15%)     
      Hyperplasia, Lobular                             2 (3%)       1 (2%)       4 (7%)       3 (5%)       6 (10%)                  
   Skin                                               (70)         (59)         (60)         (60)         (59)         (70)         
      Acanthosis                                                    2 (3%)                                 1 (2%)                   
      Cyst Epithelial Inclusion                        2 (3%)       4 (7%)       3 (5%)       2 (3%)       1 (2%)       6 (9%)      
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage                                       1 (1%)                                                           1 (1%)      
      Hyperkeratosis                                                2 (3%)                                                          
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Suppurative                                     1 (2%)       2 (3%)                                             
      Subcutaneous Tissue, Edema                                                                                        1 (1%)      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (60)         (60)         (60)         (60)         (70)         
      Calvarium, Osteopetrosis                                      1 (2%)                                 1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (60)         (60)         (60)         (60)         (70)         
      Atrophy                                                       1 (2%)                                                          
      Compression                                      4 (6%)       7 (12%)      5 (8%)       8 (13%)      4 (7%)       4 (6%)      
      Hemorrhage                                                                              1 (2%)                    1 (1%)      
      Hydrocephalus                                    1 (1%)       5 (8%)       3 (5%)       2 (3%)       2 (3%)       3 (4%)      
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                   1 (1%)                                                                       
      Necrosis                                         1 (1%)                                 1 (2%)                                
   Peripheral Nerve                                                (1)          (1)                                    (2)          
      Atrophy                                                                                                           1 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (60)         (60)         (60)         (60)         (70)         
      Congestion                                       1 (1%)       2 (3%)       4 (7%)       1 (2%)       4 (7%)       3 (4%)      
      Edema                                                         2 (3%)       3 (5%)       1 (2%)       4 (7%)       3 (4%)      
      Fibrosis                                                                                1 (2%)       1 (2%)       1 (1%)      
      Foreign Body                                                  2 (3%)       5 (8%)       2 (3%)                    3 (4%)      
      Hemorrhage                                       1 (1%)       6 (10%)      2 (3%)                    1 (2%)       1 (1%)      
      Infiltration Cellular, Histiocyte                8 (11%)     10 (17%)      8 (13%)      1 (2%)      14 (23%)      5 (7%)      
      Inflammation, Granulomatous                                                             1 (2%)                    1 (1%)      
      Inflammation, Subacute                           5 (7%)       8 (13%)      5 (8%)       5 (8%)       5 (8%)       3 (4%)      
      Inflammation, Suppurative                                     2 (3%)       1 (2%)                                             
      Metaplasia, Osseous                                                                                  1 (2%)       1 (1%)      
      Alveolar Epithelium, Hyperplasia                11 (16%)     10 (17%)      4 (7%)      10 (17%)      7 (12%)      4 (6%)      
      Fat, Mediastinum, Necrosis                       1 (1%)                    1 (2%)                                             
   Nose                                               (70)         (60)         (60)         (60)         (60)         (70)         
      Exudate                                         15 (21%)     17 (28%)     14 (23%)     12 (20%)     15 (25%)     15 (21%)     
      Foreign Body                                     4 (6%)       8 (13%)     10 (17%)      1 (2%)       2 (3%)       7 (10%)     
      Fungus                                           6 (9%)       3 (5%)       4 (7%)       3 (5%)       2 (3%)       6 (9%)      
      Mucosa, Hyperplasia                              6 (9%)       8 (13%)      1 (2%)       6 (10%)      6 (10%)      8 (11%)     
      Mucosa, Metaplasia, Squamous                     1 (1%)       3 (5%)       2 (3%)       2 (3%)       1 (2%)       5 (7%)      
   Trachea                                            (70)         (60)         (60)         (60)         (60)         (70)         
      Hemorrhage                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (2)          (3)                       (1)          
      Cataract                                                                   2 (100%)     3 (100%)                              
      Phthisis Bulbi                                                                                                    1 (100%)    
      Retina, Atrophy                                                            2 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (60)         (60)         (60)         (60)         (70)         
      Concretion                                                                 1 (2%)      13 (22%)     33 (55%)                  
      Cyst                                             1 (1%)       1 (2%)       2 (3%)                                             
      Hemorrhage                                                                 1 (2%)       1 (2%)       1 (2%)                   
      Hydronephrosis                                                             1 (2%)       1 (2%)      28 (47%)                  
      Infarct                                                                                              1 (2%)                   
      Inflammation, Suppurative                        6 (9%)       3 (5%)       7 (12%)      8 (13%)      6 (10%)      8 (11%)     
      Mineralization                                   4 (6%)       8 (13%)     10 (17%)     11 (18%)     13 (22%)      6 (9%)      
      Nephropathy                                     66 (94%)     60 (100%)    57 (95%)     60 (100%)    58 (97%)     65 (93%)     
      Papilla, Fibrosis                                                                       1 (2%)       1 (2%)                   
      Papilla, Necrosis                                                                       1 (2%)       4 (7%)                   
      Renal Tubule, Cytoplasmic Alteration                                                                              1 (1%)      
      Renal Tubule, Dilatation                         1 (1%)       1 (2%)       1 (2%)       1 (2%)      13 (22%)      4 (6%)      
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
      Renal Tubule, Hyperplasia, Oncocytic                                       1 (2%)                                             
      Renal Tubule, Pigmentation                       2 (3%)       3 (5%)       4 (7%)       2 (3%)       3 (5%)       1 (1%)      
      Transitional Epithelium, Hyperplasia            10 (14%)      5 (8%)      10 (17%)     20 (33%)     44 (73%)      4 (6%)      
      Transitional Epithelium, Hyperplasia,                                                                                         
          Atypical                                                                                         3 (5%)                   
      Transitional Epithelium, Metaplasia                                                                  1 (2%)                   
   Ureter                                                                                    (1)          (13)                      
      Concretion                                                                                           3 (23%)                  
      Dilatation                                                                              1 (100%)     2 (15%)                  
      Hemorrhage                                                                              1 (100%)                              
      Inflammation, Subacute                                                                               1 (8%)                   
      Mucosa, Hyperplasia                                                                                 12 (92%)                  
   Urethra                                                         (1)                       (2)          (5)          (1)          
      Concretion                                                                                           1 (20%)                  
      Hemorrhage                                                                              1 (50%)                               
      Inflammation, Subacute                                                                               1 (20%)                  
      Bulbourethral Gland, Ectasia                                  1 (100%)                  1 (50%)                   1 (100%)    
      Lumen, Concretion                                                                       1 (50%)      2 (40%)                  
      Lumen, Dilatation                                                                       1 (50%)                               
      Mucosa, Hyperplasia                                                                     1 (50%)      1 (20%)                  
      Mucosa, Metaplasia, Squamous                                                                         2 (40%)                  
   Urinary Bladder                                    (70)         (60)         (59)         (60)         (60)         (67)         
      Concretion                                                                              1 (2%)      10 (17%)                  
      Congestion                                                                                           1 (2%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   15                                                              
NTP Experiment-Test: 05099-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 07/18/96  
Route: GAVAGE                                                                                                     Time: 09:24:44  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Dilatation                                                    1 (2%)       1 (2%)       2 (3%)       7 (12%)                  
      Hemorrhage                                                                 1 (2%)       1 (2%)       4 (7%)                   
      Inflammation, Subacute                                                                               3 (5%)                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Mucosa, Hyperplasia                                                                    14 (23%)     41 (68%)      1 (1%)      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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