TDMS Study 05099-07 Pathology Tables
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
Facility: Southern Research Institute
Chemical CAS #: 599-79-1
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 84 MG/KG 168 337.5
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 2 2 5 4
Moribund Sacrifice 12 13 14 11
Dosing Accident 1 1 9
Survivors
Natural Death 1
Terminal Sacrifice 34 33 31 26
Moribund Sacrifice 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (60) (59)
Schwannoma Malignant 1 (2%)
Intestine Small, Duodenum (60) (60) (60) (60)
Leiomyoma 1 (2%)
Liver (60) (60) (60) (60)
Carcinoma, Metastatic, Uterus 1 (2%)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (4) (8) (5) (6)
Carcinoma, Metastatic, Uterus 1 (13%)
Fibroma 1 (13%)
Pancreas (60) (60) (60) (60)
Pharynx (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
Stomach, Forestomach (60) (59) (60) (60)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (60) (60) (60) (60)
Tongue (1) (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Schwannoma Malignant 3 (5%) 3 (5%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 84 MG/KG 168 337.5
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Adrenal Medulla (60) (60) (60) (60)
Ganglioneuroma 1 (2%)
Pheochromocytoma Benign 3 (5%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (60) (60) (60)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (60) (59) (60) (60)
Pars Distalis, Adenoma 27 (45%) 20 (34%) 24 (40%) 13 (22%)
Pars Distalis, Carcinoma 2 (3%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Adenoma 3 (5%) 5 (8%) 2 (3%) 5 (8%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (3%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (60) (60) (60)
Adenoma 2 (3%) 3 (5%) 2 (3%) 2 (3%)
Carcinoma 1 (2%) 2 (3%) 1 (2%)
Ovary (60) (60) (60) (60)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (60) (60) (60) (60)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Polyp Stromal 6 (10%) 8 (13%) 8 (13%) 4 (7%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 84 MG/KG 168 337.5
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (12) (9) (9) (7)
Lymph Node, Mandibular (60) (58) (60) (60)
Lymph Node, Mesenteric (60) (60) (59) (60)
Spleen (60) (60) (60) (60)
Thymus (59) (59) (60) (60)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (58)
Adenoma 1 (2%) 2 (3%)
Carcinoma 2 (3%) 3 (5%) 1 (2%)
Fibroadenoma 18 (30%) 8 (13%) 18 (30%) 5 (9%)
Fibroadenoma, Multiple 4 (7%) 1 (2%) 2 (3%)
Skin (60) (60) (60) (60)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Squamous Cell Papilloma 3 (5%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (1)
Carcinoma, Metastatic, Uterus 1 (100%)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 3 (5%)
Glioma Malignant, Mixed 1 (2%)
Meningioma Malignant 1 (2%)
Spinal Cord (2)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 84 MG/KG 168 337.5
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Nose (60) (60) (60) (60)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Renal Tubule, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 2 (3%)
Urinary Bladder (59) (60) (60) (60)
Papilloma 2 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 15 (25%) 9 (15%) 9 (15%) 3 (5%)
Lymphoma Malignant 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 84 MG/KG 168 337.5
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 43 49 33
Total Primary Neoplasms 91 72 88 50
Total Animals with Benign Neoplasms 42 32 45 27
Total Benign Neoplasms 69 50 70 37
Total Animals with Malignant Neoplasms 22 20 17 12
Total Malignant Neoplasms 22 21 18 13
Total Animals with Metastatic Neoplasms 5 2
Total Metastatic Neoplasm 8 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 60 60 60 60 70
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 13 16 11 16 15 13
Natural Death 1 1 2 2 10 4
Dosing Accident 1 2 4 1 2 3
Survivors
Terminal Sacrifice 35 31 33 30 23 30
Natural Death 1
Animals Examined Microscopically 70 60 60 60 60 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (69) (60) (59) (60) (58) (68)
Adenoma 1 (2%)
Carcinoma 1 (1%)
Intestine Large, Rectum (69) (60) (60) (60) (59) (69)
Polyp 1 (2%)
Intestine Large, Cecum (70) (60) (60) (60) (60) (70)
Sarcoma 1 (2%)
Intestine Small, Duodenum (70) (60) (60) (60) (60) (69)
Carcinoma 1 (1%)
Intestine Small, Jejunum (70) (60) (59) (60) (59) (69)
Intestine Small, Ileum (69) (60) (59) (60) (60) (69)
Leiomyosarcoma 1 (1%)
Liver (70) (60) (60) (60) (60) (70)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 2 (3%) 2 (3%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Tissue NOS 1 (2%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (2%)
Mesentery (19) (19) (17) (19) (14) (18)
Fibrous Histiocytoma 1 (5%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (5%)
Osteosarcoma, Metastatic, Tissue NOS 1 (5%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (5%)
Pancreas (70) (60) (60) (60) (60) (68)
Page 7
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Fibrous Histiocytoma 1 (1%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (1%)
Mixed Tumor Benign 1 (2%) 1 (2%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (2%)
Acinar Cell, Adenoma 9 (13%) 10 (17%) 6 (10%) 5 (8%) 10 (17%) 2 (3%)
Acinar Cell, Adenoma, Multiple 3 (4%) 2 (3%) 2 (3%) 2 (3%)
Acinar Cell, Carcinoma, Multiple 1 (1%)
Pharynx (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%) 1 (100%)
Salivary Glands (70) (60) (59) (60) (60) (70)
Adenoma 1 (2%)
Schwannoma Malignant 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (1%)
Stomach, Forestomach (70) (60) (60) (60) (60) (70)
Leiomyosarcoma 1 (1%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (1%)
Stomach, Glandular (69) (60) (60) (60) (60) (70)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (70) (60) (60) (60) (60) (70)
Vena Cava, Chordoma, Metastatic, Spinal Cord 1 (2%)
Heart (70) (60) (60) (60) (60) (70)
Schwannoma Benign 1 (2%) 2 (3%) 1 (1%)
Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (60) (60) (60) (60) (70)
Adenoma 1 (2%) 2 (3%)
Histiocytic Sarcoma 1 (2%)
Adrenal Medulla (70) (60) (59) (60) (59) (70)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (3%)
Pheochromocytoma Complex 1 (1%)
Pheochromocytoma Benign 12 (17%) 7 (12%) 6 (10%) 5 (8%) 7 (12%) 4 (6%)
Bilateral, Pheochromocytoma Benign 3 (4%) 2 (3%) 1 (2%) 1 (2%) 1 (2%) 1 (1%)
Islets, Pancreatic (70) (60) (60) (60) (60) (69)
Adenoma 2 (3%) 2 (3%) 3 (5%) 6 (10%) 5 (8%) 1 (1%)
Carcinoma 1 (1%) 1 (2%) 1 (2%)
Pituitary Gland (70) (58) (60) (59) (59) (68)
Page 8
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Ganglioneuroma 1 (1%)
Pars Distalis, Adenoma 15 (21%) 23 (40%) 19 (32%) 18 (31%) 18 (31%) 20 (29%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (70) (60) (60) (60) (60) (70)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 3 (4%) 6 (10%) 9 (15%) 5 (8%) 6 (10%) 4 (6%)
C-Cell, Carcinoma 2 (3%) 1 (2%) 2 (3%) 1 (2%) 2 (3%)
Follicular Cell, Adenoma 4 (6%) 3 (5%) 1 (2%)
Follicular Cell, Carcinoma 1 (1%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Osteosarcoma 1 (100%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (60) (60) (60) (60) (70)
Preputial Gland (70) (60) (60) (60) (60) (70)
Adenoma 1 (1%) 1 (2%) 3 (5%) 5 (7%)
Carcinoma 2 (3%) 1 (2%) 3 (5%) 2 (3%)
Prostate (70) (60) (60) (60) (60) (70)
Adenoma 1 (2%)
Seminal Vesicle (70) (60) (60) (60) (59) (70)
Testes (70) (60) (59) (60) (60) (70)
Bilateral, Interstitial Cell, Adenoma 50 (71%) 40 (67%) 43 (73%) 45 (75%) 52 (87%) 37 (53%)
Interstitial Cell, Adenoma 4 (6%) 13 (22%) 5 (8%) 11 (18%) 3 (5%) 9 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (60) (60) (60) (60) (70)
Histiocytic Sarcoma 1 (2%)
Lymph Node (9) (16) (15) (14) (10) (7)
Inguinal, Fibrous Histiocytoma, Metastatic,
Skin 1 (10%)
Mediastinal, Osteosarcoma, Metastatic,
Tissue NOS 1 (7%)
Mediastinal, Sarcoma, Metastatic, Intestine
Large, Cecum 1 (6%)
Pancreatic, Histiocytic Sarcoma 1 (7%)
Lymph Node, Mandibular (70) (59) (60) (60) (59) (70)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (70) (60) (60) (60) (59) (69)
Page 9
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Sarcoma, Metastatic, Intestine Large, Cecum 1 (2%)
Spleen (70) (60) (60) (60) (60) (70)
Fibrosarcoma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (1%)
Osteosarcoma, Metastatic, Tissue NOS 1 (2%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (2%)
Thymus (66) (60) (58) (59) (59) (69)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (67) (58) (58) (57) (59) (68)
Carcinoma 1 (2%)
Fibroadenoma 3 (4%) 1 (2%) 4 (7%) 4 (7%) 3 (5%) 4 (6%)
Fibroadenoma, Multiple 1 (2%)
Skin (70) (59) (60) (60) (59) (70)
Basal Cell Adenoma 2 (3%) 3 (5%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 3 (4%) 2 (3%) 3 (5%) 3 (5%) 2 (3%) 3 (4%)
Squamous Cell Papilloma 1 (1%) 2 (3%) 2 (3%) 3 (5%) 1 (2%) 1 (1%)
Trichoepithelioma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 2 (3%) 3 (5%) 5 (8%) 1 (2%) 3 (5%) 6 (9%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (1%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (60) (60) (60) (60) (70)
Hamartoma 1 (2%)
Osteosarcoma 1 (2%) 1 (1%)
Skeletal Muscle (1) (1) (1) (1) (1) (1)
Fibrous Histiocytoma 1 (100%)
Hemangiosarcoma 1 (100%)
Histiocytic Sarcoma 1 (100%)
Osteosarcoma, Metastatic, Tissue NOS 1 (100%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (100%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (60) (60) (60) (60) (70)
Astrocytoma Malignant 1 (1%)
Glioma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
Meningioma Benign 1 (1%)
Spinal Cord (1) (1) (1) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (60) (60) (60) (60) (70)
Alveolar/Bronchiolar Adenoma 2 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (1%) 2 (3%)
Chordoma, Metastatic, Spinal Cord 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (1%)
Osteosarcoma, Metastatic, Tissue NOS 1 (2%)
Sarcoma, Metastatic, Intestine Large, Cecum 1 (2%)
Nose (70) (60) (60) (60) (60) (70)
Squamous Cell Carcinoma 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (60) (60) (60) (60) (70)
Lipoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (70) (60) (59) (60) (60) (67)
Papilloma 2 (3%) 4 (7%)
Papilloma, Multiple 2 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(60) *(60) *(60) *(60) *(70)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 13 (19%) 10 (17%) 18 (30%) 12 (20%) 3 (5%) 10 (14%)
Mesothelioma Malignant 1 (1%) 1 (2%) 1 (2%) 2 (3%) 3 (5%) 2 (3%)
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(70) *(60) *(60) *(60) *(60) *(70)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05099-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/03/96
Route: GAVAGE Time: 19:12:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG 84 MG/KG 168 337.5 337.5
FEED RTD MG/KG MG/KG STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 58 59 56 59 58 56
Total Primary Neoplasms 156 141 143 152 134 133
Total Animals with Benign Neoplasms 58 59 54 58 57 52
Total Benign Neoplasms 124 122 114 124 122 106
Total Animals with Malignant Neoplasms 25 16 24 23 9 21
Total Malignant Neoplasms 32 19 29 28 12 27
Total Animals with Metastatic Neoplasms 2 1 4 5 4
Total Metastatic Neoplasm 5 9 12 13 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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