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https://ntp.niehs.nih.gov/go/3355

TDMS Study 05099-07 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                      SALICYLAZOSULFAPYRIDINE


NTP Experiment-Test: 05099-07                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 04/07/95
Route: GAVAGE                                                                                                     Time: 00:41:54


                                                           CORE STUDY


       Facility:  Southern Research Institute

       Chemical CAS #:  599-79-1

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    0 MG/KG
                               Include 003    84 MG/KG
                               Include 004    84 MG/KG
                               Include 005    168     MG/KG
                               Include 006    168     MG/KG
                               Include 007    337.5   MG/KG
                               Include 008    337.5   MG/KG

























                                                             Page   1
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|             
                                           | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X        X  X              X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               4                                          |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X|             
      Clear Cell Focus                     |             X                                         X  X           X   |             
      Eosinophilic Focus                   |                                        X  X  X                 X     X  X|             
      Granuloma                            |       1     1  1           1                                   3        1|             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hepatodiaphragmatic Nodule           |             X        X                                                   |             
      Mixed Cell Focus                     |                         X  X  X           X     X        X     X         |             
      Bile Duct, Hyperplasia               |    1        1     1  1           2        1  1              1            |             
      Centrilobular, Atrophy               |                         2                                   2            |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  4                 1        2            |             
      Kupffer Cell, Pigmentation           |                                                    3                     |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                                                            |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |    2        3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1        1              1     1  1           1     1  1  3        2   |             
      Metaplasia, Hepatocyte               | X                                                                        |             
      Acinar Cell, Cytoplasmic Alteration  |                                                    3                     |             
      Acinar Cell, Hyperplasia, Focal      |                                                                         2|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                  2  3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|             
                                           | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                     2                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
      Mucosa, Hyperplasia                  |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2        1        1     1  1              1                           |             
      Inflammation, Subacute               |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X  X     X     X  X  X           X        X                        |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                1         |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Focal                   |                   1                             1        2               |             
      Hypertrophy, Focal                   |                                  1     1                                 |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              4                           |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             3           2  2  2        3        4  2  4                  |             
      Pars Distalis, Cyst                  | X  X  X     X  X  X     X  X  X  X  X  X        X  X  X  X              X|             
      Pars Distalis, Hyperplasia, Focal    |    2              4     1  1  3                    2                     |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                         X           X                    X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |             X                                                            |             
      C-Cell, Hyperplasia                  |    2                                      1     2                    1   |             
      Follicle, Cyst                       |    X                       X           X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          3  3        4  2              3           3     2              2|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|             
                                           | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |             2                                                            |             
      Inflammation, Suppurative            |          2                                                              1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X     X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                  3                                       |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +           +           +        +              +            |             
      Mediastinal, Hemorrhage              |       2     3                                2                           |             
      Mediastinal, Pigmentation            | 3     3     3           3                    3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2                 2                                             |             
      Hemorrhage                           |                                                                2         |             
      Hyperplasia, Lymphoid                |                                                    2                 3   |             
      Pigmentation                         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                1                                3                        |             
      Pigmentation                         |       2                          2     3     2                          2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     | 2  2  2  2     2  2  2     2  2           2  2  2     2  2               |             
      Hemorrhage                           | 4                                                                        |             
      Necrosis                             |                                                             2            |             
      Pigmentation, Hemosiderin            |    2  3  2  2  2  2     1  2  3           3  3  2  3  2  3     3  3  2  3|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    1                                   2     1                           |             
      Hyperplasia, Lobular                 | 3           2     2        2                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 1                        |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|             
                                           | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteopetrosis             |                                           2                              |             
      Femur, Osteopetrosis                 |                                                                2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X                                         X  X                 X         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                2         |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Foreign Body                         |                                                                          |             
      Infiltration Cellular, Histiocyte    |                1  1           1  2        1                    1     1   |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                X                          X        X                     |             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Mucosa, Hyperplasia                  |                1                                                         |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cataract                             |                         3                                                |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Retina, Atrophy                      |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
      Mineralization                       | 2  3  2  1  1  1  2     2  1  1     2  2  1  2  2     2  2     1  2  1  2|             
      Nephropathy                          | 1  2  1  1  1  1        1     1        1  1  3  1     1  1  1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|             
                                           | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0 MG/KG                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Dilatation             |                            2                                             |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                                  2           3     2        3            |             
      Transitional Epithelium, Hyperplasia |                                  2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|            |
                                           | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation                          |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                          X        X           X                  |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                              X     X                     |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Inflammation, Subacute               |    2                                                                     |      1  2.0|
      Parasite Metazoan                    |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      2  3.0|
      Basophilic Focus                     | X     X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     45     |
      Clear Cell Focus                     |                                     X     X     X     X              X   |      9     |
      Eosinophilic Focus                   | X              X        X                       X  X     X  X            |     13     |
      Granuloma                            | 1        1                          1     1     1     1  3  3        1   |     15  1.4|
      Hematopoietic Cell Proliferation     |       2                                                                  |      2  2.0|
      Hepatodiaphragmatic Nodule           |                            X  X                    X                    X|      6     |
      Mixed Cell Focus                     |                         X              X                             X   |     10     |
      Bile Duct, Hyperplasia               | 1  1                          3        1  1  1        1              1   |     16  1.2|
      Centrilobular, Atrophy               |       2                       2                                          |      4  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                   2                                                      |      4  2.3|
      Kupffer Cell, Pigmentation           |          1                    4                                          |      3  2.7|
      Lobules, Necrosis                    |    1                                         1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                            +                     |   4        |
      Accessory Spleen                     |                                                    X                     |      1     |
      Fat, Necrosis                        |       3                                                                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      1  1        1  1           1     2  2               |     17  1.3|
      Metaplasia, Hepatocyte               |                                                                          |      1     |
      Acinar Cell, Cytoplasmic Alteration  |    3                                                                     |      2  3.0|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2                                                                     |      1  2.0|
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|            |
                                           | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |    2                                                                     |      1  2.0|
      Ulcer                                |    4                                                                     |      1  4.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                           1                              |      2  1.5|
      Ulcer                                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Mucosa, Hyperplasia                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2        1     1                    1                       2     1   |     12  1.3|
      Inflammation, Subacute               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                            X        X           X           X           X|     13     |
      Cyst                                 |                                  X                                       |      1     |
      Degeneration, Fatty                  |                1           1                       2        4            |      5  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   | 2                          1                                   2         |      6  1.5|
      Hypertrophy, Focal                   |                1                       3           2                 2   |      6  1.7|
      Necrosis                             |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                                                        |      2  3.0|
      Necrosis                             |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                           1              3     2  3      |     12  2.6|
      Pars Distalis, Cyst                  |    X     X                 X  X  X        X  X  X     X           X  X  X|     29     |
      Pars Distalis, Hyperplasia, Focal    | 3           3                       2                 2     3            |     11  2.4|
      Pars Intermedia, Angiectasis         |                      3                                   3               |      2  3.0|
      Pars Intermedia, Cyst                |                                                       X                  |      4     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                      X              X                                    |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|            |
                                           | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |       3                             2                 1                  |      7  1.7|
      Follicle, Cyst                       |                                                             X            |      4     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          2                       3     3  3  2        3        3     3  3|     17  2.8|
      Hyperplasia                          |                            2                                             |      1  2.0|
      Inflammation, Chronic                |                                        2  2                             3|      4  2.3|
      Inflammation, Suppurative            |                                                             4           3|      4  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         X           X     X  X     X                     |      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hydrometra                           | 2                          2                                            2|      3  2.0|
      Hyperplasia, Cystic                  | 2           2                                                            |      3  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    M                                                                     |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |    2                                                     3               |      3  2.7|
      Necrosis                             |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +           +           +                              |  12        |
      Mediastinal, Hemorrhage              |    2              2                       3                              |      6  2.3|
      Mediastinal, Pigmentation            |       3                                   4                              |      7  3.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |       2                       3  2              2                       2|      7  2.1|
      Hemorrhage                           |                                                    1           1         |      3  1.3|
      Hyperplasia, Lymphoid                |                                  3  2                                    |      4  2.5|
      Pigmentation                         |       2     2                          2     2                 2         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Pigmentation                         | 2           3                       2                 3        3         |     10  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |       3                       2                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |       2     2  2  2  2           2        2        2     2  2     2      |     25  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|            |
                                           | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            | 3     2  1     3     3  3     2  3  2  2  2     3  2  2  2     2  2  2  2|     38  2.3|
      Lymphoid Follicle, Atrophy           |                                     2                                    |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |    1           2           1  1  1  1  2                                 |     10  1.3|
      Hyperplasia, Lobular                 |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  1.0|
      Cyst Epithelial Inclusion            |                                           X                              |      1     |
      Inflammation, Chronic                |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calvarium, Osteopetrosis             |       2        2                    2                                    |      4  2.0|
      Femur, Osteopetrosis                 |       2              4                             2                 4   |      5  2.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +           +                                          |   2        |
      Hemorrhage                           |                               3                                          |      1  3.0|
      Inflammation, Chronic                |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                X        X           X  X     X              X            |     10     |
      Hemorrhage                           |    3                 3                                                   |      2  3.0|
      Hydrocephalus                        |                2                       2                                 |      3  2.0|
      Necrosis                             |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                      3                                                   |      1  3.0|
      Edema                                |                   2                                                      |      1  2.0|
      Foreign Body                         |                                  1                                       |      1  1.0|
      Infiltration Cellular, Histiocyte    |       1                    1        1                 2  1  1           1|     14  1.1|
      Inflammation, Subacute               |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           1                              |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|            |
                                           | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                      X     X     X              X     X  X               |      9     |
      Foreign Body                         | 2                    2                          2                        |      3  2.0|
      Fungus                               |                                                 X                        |      1     |
      Mucosa, Hyperplasia                  |                                                 2     1           2      |      4  1.5|
      Mucosa, Metaplasia, Squamous         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                       +               |   3        |
      Cataract                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                          3               |      1  3.0|
      Inflammation, Suppurative            |                                  4                                       |      1  4.0|
      Retina, Atrophy                      |                                                          1               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       | 2  1  1  1  2  2  2  3  3  1  2     1  2  2  1  3  2  2  1  2  1  2  1   |     44  1.7|
      Nephropathy                          | 1              1  1  1  2  1     1     2  1  1  1  1  1  1     1     1   |     34  1.1|
      Renal Tubule, Dilatation             |                                                       2                  |      2  2.0|
      Renal Tubule, Necrosis               |    2                                                                     |      1  2.0|
      Renal Tubule, Pigmentation           |    2                          2  2              2                        |      8  2.3|
      Transitional Epithelium, Hyperplasia |    1                                   1                                 |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Hyperplasia                  |                            1                                             |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|             
                                           | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    84 MG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                      X        X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1           3  3                                                         |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X     X  X  X  X  X  X|             
      Clear Cell Focus                     |                      X                       X                    X  X   |             
      Eosinophilic Focus                   | X  X  X  X                 X     X        X     X        X               |             
      Granuloma                            |       1           2  1                                   1  1            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                    X     X                 X      |             
      Mixed Cell Focus                     |                   X                                                     X|             
      Bile Duct, Hyperplasia               |             1              1              1        1                 1   |             
      Centrilobular, Atrophy               |    2                                      3                              |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Lobules, Necrosis                    |    1        2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +     +                             +                  |             
      Fat, Necrosis                        |       3                                               3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      3  1        3           1           1     1  1     1|             
      Metaplasia, Hepatocyte               |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                            3                                             |             
      Acinar Cell, Hyperplasia, Focal      |          2                          4                                1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                   1                                                      |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       4                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1  2  1                 1  1  1                          1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|             
                                           | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    84 MG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X           X  X  X  X                                               X|             
      Angiectasis                          |                                  2           3           3               |             
      Degeneration, Fatty                  | 1              1     2                                4                 1|             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Diffuse                 |                                                       3                  |             
      Hyperplasia, Focal                   |                      1                       1  1                    1   |             
      Hypertrophy, Focal                   | 2                                                        3               |             
      Necrosis                             |                                                       1                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                          3                    2              1|             
      Pars Distalis, Cyst                  | X  X        X        X        X     X  X     X     X     X     X     X  X|             
      Pars Distalis, Hyperplasia, Focal    | 3           1     1                 3        3  3        1     3     2   |             
      Pars Intermedia, Angiectasis         |                                     2                                    |             
      Pars Intermedia, Cyst                |                                                                X  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 | X                                                                        |             
      C-Cell, Hyperplasia                  | 2                 1              2     1           1        1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    2     3  2                                3  3  4     3           2   |             
      Hyperplasia                          |             1                                                  4         |             
      Inflammation, Chronic                |             2                    2  2        2     2     2        2  2  2|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          3              2                                                |             
      Hyperplasia, Cystic                  |                      2              2                                    |             
      Endometrium, Hyperplasia, Focal      |                                              4                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |             2                                                            |             
      Myelofibrosis                        |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|             
                                           | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    84 MG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +     +                 +        +                     |             
      Mediastinal, Hemorrhage              |                   3     3                          2                     |             
      Mediastinal, Pigmentation            |    3              3                                3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ectasia                              |                               2                    2           2         |             
      Hemorrhage                           |                2                                                         |             
      Hyperplasia, Lymphoid                |             2                                                  3         |             
      Hyperplasia, Plasma Cell             |                            3                                             |             
      Pigmentation                         |    2  2           2  2     3           2                 2  2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                         1  1                          4                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |          3                       3           2                          2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           2                              |             
      Hematopoietic Cell Proliferation     |    2  2  2  2           3  2     2           2        2  2  2     2  2   |             
      Pigmentation, Hemosiderin            | 3     3  2     3     2     3  3  3  3                 2  2  2  3  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      1     1           1     4        3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteopetrosis             |                   2                                                      |             
      Femur, Osteopetrosis                 |                                                 2  3                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Compression                          |       X        X           X     X                                       |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                2                                                         |             
      Mineralization                       |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|             
                                           | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    84 MG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1     1           1        1     2        1  1           1  1  3      |             
      Inflammation, Subacute               |                               1              1                           |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1        2                                   2     3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |    X        X              X                 X                       X  X|             
      Foreign Body                         | 2  2        2                       1                                    |             
      Fungus                               |    X                                         X                           |             
      Mucosa, Hyperplasia                  |                                              2                       2   |             
      Mucosa, Metaplasia, Squamous         |    2                                         2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                3         |             
      Phthisis Bulbi                       |                                                                          |             
      Retina, Atrophy                      |                                                                4         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                       3     1     1  1  2|             
      Cyst                                 |                                                                          |             
      Mineralization                       | 2  2  3  3  2  1  2  1     2  2  2  1  1     1  3  1  1  1  2  1  2  1  2|             
      Nephropathy                          | 1  1  1  1        1  1     1  1  2  1  1  1     1  1  3  1  2  1  1  2   |             
      Renal Tubule, Dilatation             |                                                       2                  |             
      Renal Tubule, Hyperplasia            |                                        4                                 |             
      Renal Tubule, Pigmentation           |                2                          2                              |             
      Transitional Epithelium, Hyperplasia |             1                                         2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4|            |
                                           | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    84 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                                X                       X              X|      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                       X                  |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      3  2.3|
      Basophilic Focus                     | X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X     X     X  X  X  X|     43     |
      Clear Cell Focus                     | X  X                                               X                     |      7     |
      Eosinophilic Focus                   |                                           X     X  X              X      |     13     |
      Granuloma                            |    1                                                     1           1   |      8  1.1|
      Hematopoietic Cell Proliferation     |                                                                1         |      1  1.0|
      Hepatodiaphragmatic Nodule           |                X        X  X           X     X                           |      9     |
      Mixed Cell Focus                     |                      X        X           X           X           X      |      7     |
      Bile Duct, Hyperplasia               |          2  1           2  1           1  1                              |     11  1.2|
      Centrilobular, Atrophy               |                                                                          |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|          4                                                               |      1  4.0|
      Lobules, Necrosis                    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                       +                                   +         |   7        |
      Fat, Necrosis                        |    2                       2                                             |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1     1                    1  1  2     2           1  1   |     16  1.4|
      Metaplasia, Hepatocyte               |                      X                                                   |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                      3                                                   |      2  3.0|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                               2                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4|            |
                                           | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    84 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1                                                  2           1         |     11  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                        X              X                  |      8     |
      Angiectasis                          |                                  3        4                              |      5  3.0|
      Degeneration, Fatty                  |             1                             4     2              1  2      |     10  1.9|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |    1                                                                 1   |      6  1.0|
      Hypertrophy, Focal                   |                                                 2                       2|      4  2.3|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                                                                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                2         |      5  2.0|
      Pars Distalis, Cyst                  | X  X  X  X     X     X           X              X  X        X  X  X  X   |     26     |
      Pars Distalis, Hyperplasia, Focal    | 4        3                                         1                 1   |     13  2.2|
      Pars Intermedia, Angiectasis         |                         3                                               2|      3  2.3|
      Pars Intermedia, Cyst                |    X                    X                          X                     |      5     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                                  1        1     1        1               |     10  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |    3                       4  3           2        3  3  4               |     15  2.9|
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Chronic                |                   2              2           2     3  2              2   |     15  2.1|
      Inflammation, Suppurative            |                            2                       2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                       X        X|      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4|            |
                                           | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    84 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                  2                                       |      3  2.3|
      Hyperplasia, Cystic                  |                                                                          |      2  2.0|
      Endometrium, Hyperplasia, Focal      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |          M                                                     +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                                                                4  2      |      3  2.7|
      Myelofibrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +               |   6        |
      Mediastinal, Hemorrhage              |                                                          3               |      4  2.8|
      Mediastinal, Pigmentation            |                                                          4               |      4  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Ectasia                              |                   2        2              2           2                  |      7  2.0|
      Hemorrhage                           |                1                          2                              |      3  1.7|
      Hyperplasia, Lymphoid                |                            2                          3        2         |      5  2.4|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Pigmentation                         |                      2     3                          2  3     2        2|     14  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                1                                                         |      1  1.0|
      Hemorrhage                           |                                              1                           |      4  1.8|
      Hyperplasia, Lymphoid                |                                                       2                  |      1  2.0|
      Pigmentation                         |                3                                3  3              3     2|      9  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    2        2  2  2                 2  2  2     2  2     2     3  3  2  2|     27  2.1|
      Pigmentation, Hemosiderin            | 2     3     1  2     2  2  3  4     2  3     2     3  2  2  2     2     2|     33  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                         X|      1     |
      Hemorrhage                           |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                        3  3           2        2  1      |     10  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4|            |
                                           | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    84 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Calvarium, Osteopetrosis             |                                                                          |      1  2.0|
      Femur, Osteopetrosis                 |          3                                                               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Compression                          |             X              X  X     X  X  X           X                  |     11     |
      Hemorrhage                           |                               3        2                                 |      2  2.5|
      Hydrocephalus                        |                            2                          2                  |      3  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                               2     3                       3            |      3  2.7|
      Edema                                |                                                             2            |      1  2.0|
      Foreign Body                         |                                                       1     2            |      2  1.5|
      Hemorrhage                           | 1                                                     1                  |      2  1.0|
      Infiltration Cellular, Histiocyte    |       2                                            1              3      |     13  1.5|
      Inflammation, Subacute               |    1                                      1           2                  |      5  1.2|
      Thrombosis                           |                                                                X         |      1     |
      Alveolar Epithelium, Hyperplasia     | 2                                         1           2                  |      7  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                   X           X                             X            |      9     |
      Foreign Body                         |    2              1                                                      |      6  1.7|
      Fungus                               |                                                                          |      2     |
      Mucosa, Hyperplasia                  |                                                                          |      2  2.0|
      Mucosa, Metaplasia, Squamous         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +           +  +                                +                  |   5        |
      Cataract                             |       2           4                                                      |      3  3.0|
      Phthisis Bulbi                       |                      X                                X                  |      2     |
      Retina, Atrophy                      |                   4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4|            |
                                           | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    84 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Concretion                           |                                     1              2     2        1      |      9  1.6|
      Cyst                                 |          X                                                               |      1     |
      Mineralization                       | 2  3  2  1  2  2  1  1  1  2  2  2  2  1  2  1  2  3  3     1  2  2  1  1|     47  1.7|
      Nephropathy                          |             1  1  2        1     1  1  1  1  1     1  2  1     1  1  1  1|     36  1.2|
      Renal Tubule, Dilatation             |                                                                         2|      2  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |          3              2                                      2  2      |      6  2.2|
      Transitional Epithelium, Hyperplasia |                1                    1              2     1        1      |      7  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|             
                                           | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                  X  X  X     X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X  X                                               X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                   1                             1|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X|             
      Clear Cell Focus                     |       X                       X                 X        X        X      |             
      Developmental Malformation           |                                                                X         |             
      Eosinophilic Focus                   |             X  X           X                             X  X        X   |             
      Granuloma                            |                                           1                       1  2   |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Mixed Cell Focus                     | X  X        X        X                                            X  X   |             
      Bile Duct, Hyperplasia               | 2        1        3                                   1     1     1     1|             
      Lobules, Necrosis                    |                                  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Fat, Necrosis                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1     1                    2                    1                 2      |             
      Metaplasia, Hepatocyte               |                                                                X         |             
      Acinar Cell, Cytoplasmic Alteration  |                3                                   3                     |             
      Acinar Cell, Hyperplasia, Focal      |                                                          4              2|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                2                                                         |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1              2     1        1        1        2               |             
      Mineralization                       |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|             
                                           | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X           X                 X     X        X  X  X               |             
      Angiectasis                          |                                                                      3   |             
      Cyst                                 |                                                                      X   |             
      Degeneration, Fatty                  |                                        2                                 |             
      Hyperplasia, Focal                   |    1                                                     1               |             
      Hypertrophy, Focal                   |                         1              1                 2        1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                 3                             4               |             
      Pars Distalis, Cyst                  | X  X  X  X        X                 X           X              X        X|             
      Pars Distalis, Hyperplasia, Focal    |          3                                               2     3        3|             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   X                                               X      |             
      C-Cell, Hyperplasia                  | 2        2        1                                   2  4        2      |             
      Follicle, Cyst                       |          X                 X                                            X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3  3     3     2           2                 3                    2  2|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |       2                                3        3                        |             
      Inflammation, Suppurative            |             2     3                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                            3                                            2|             
      Hyperplasia, Cystic                  |                   1                                                      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|             
                                           | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +        +        +     +                                       |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |          1                                                               |             
      Mediastinal, Pigmentation            | 3        2                 3     3                                       |             
      Pancreatic, Hemorrhage               |       2                                                                  |             
      Pancreatic, Pigmentation             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                              1                    1      |             
      Hyperplasia, Lymphoid                |                                              3                           |             
      Pigmentation                         |    2                                   3              3  3        3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                3        3                                3        3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |       X                                                                  |             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     | 2     2  2  2        2  2  2  2  2  2  2     2  2     2  2  2     2  2  2|             
      Hemorrhage                           |                                  3                                       |             
      Pigmentation, Hemosiderin            |    2  2  3  3  3     3  2  3  2     2  3  4     2     3  2  3     2  3  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    1           2     1  1     2        2  1  1     1  2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3                                         1        2            |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Ulcer                                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteopetrosis             |                                                                          |             
      Femur, Osteopetrosis                 |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X     X                    X        X        X            |             
      Hydrocephalus                        |                                           2        2                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|             
                                           | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3     2                                             |             
      Edema                                |                            2                             2               |             
      Foreign Body                         |                            2                                             |             
      Infiltration Cellular, Histiocyte    |    1                          1           1           1     2        1   |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          X        X                 X              X        X     X      |             
      Foreign Body                         |                                     1     2  2                    2      |             
      Mucosa, Hyperplasia                  |          2                                                               |             
      Mucosa, Metaplasia, Squamous         |          1                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                                                          |             
      Phthisis Bulbi                       |                                              X                           |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |       2  1  1  2  2  1  3  2  1  1     2  1  3  2        2        2  1  2|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                         2                                                |             
      Mineralization                       | 2     1  3  1  2     2  1  2  2  2  2  2  2     2  1  2        1  2  2  2|             
      Nephropathy                          | 1  1     1  1  3     1  2  1  1     1  2  1  3  1  1  1  1        1  1  1|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Hyperplasia            |          2                                                               |             
      Renal Tubule, Pigmentation           |                   2                          4                           |             
      Transitional Epithelium, Hyperplasia | 1              1  1  1  2  1     1           2  1                 1  1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Concretion                           |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Mucosa, Hyperplasia                  |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|            |
                                           | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                         X|      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                      X  X                                                |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   X     X|      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1              3                             4  4            |      7  2.3|
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     47     |
      Clear Cell Focus                     |             X     X        X  X        X  X                              |     11     |
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |    X  X  X           X  X  X           X  X  X        X  X  X  X         |     19     |
      Granuloma                            |                   1           1                                          |      5  1.2|
      Hepatodiaphragmatic Nodule           |             X        X                                      X            |      4     |
      Mixed Cell Focus                     |                                     X  X  X        X  X                  |     11     |
      Bile Duct, Hyperplasia               |                                           1                    1         |      9  1.3|
      Lobules, Necrosis                    |                   1                                      1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                       +                                +|   4        |
      Fat, Necrosis                        |                3                       3                                2|      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  3        1     1        2  2  1                             1     1   |     14  1.5|
      Metaplasia, Hepatocyte               |                                                                          |      1     |
      Acinar Cell, Cytoplasmic Alteration  |             3  3                                                         |      4  3.0|
      Acinar Cell, Hyperplasia, Focal      |                                              1                    2      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                +         |   1        |
      Mucosa, Hyperplasia                  |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|            |
                                           | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                      1     1           1     1  2     2  1        3  1  1|     16  1.4|
      Mineralization                       |                               2                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    | X                                                     X              X   |     10     |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |       1     1                    1                                   1  1|      6  1.2|
      Hyperplasia, Focal                   |                                        1     1     1  1  1        1  1   |      9  1.0|
      Hypertrophy, Focal                   |                                                       1                  |      5  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                          2               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |          2        2                                   3              2   |      7  2.6|
      Pars Distalis, Cyst                  |       X     X  X  X     X     X     X                          X  X      |     18     |
      Pars Distalis, Hyperplasia, Focal    |       3  2     1        2     3     2                 2           2      |     12  2.3|
      Pars Intermedia, Angiectasis         |                                        2                                 |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                        X                                 |      3     |
      C-Cell, Hyperplasia                  |          1                                         1        2        1   |     10  1.8|
      Follicle, Cyst                       |                                                                   X      |      4     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |             2  2  2     3  2           4           2  3  3               |     17  2.5|
      Hyperplasia                          |             2                                                            |      1  2.0|
      Inflammation, Chronic                |                2     2     2     2                 2                     |      8  2.3|
      Inflammation, Suppurative            |                         2              2                                 |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|            |
                                           | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |             3        3                                                  1|      5  2.4|
      Hyperplasia, Cystic                  |                                                                   2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  | M  +                                                                     |   1        |
      Hyperplasia                          |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                4                                                         |      2  3.0|
      Myelofibrosis                        |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                 +                                      +|   9        |
      Mediastinal, Ectasia                 |                2                                                         |      1  2.0|
      Mediastinal, Hemorrhage              |                1                                                        3|      3  1.7|
      Mediastinal, Pigmentation            |                3                 3                                      4|      7  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                               2                                   2  2   |      3  2.0|
      Hemorrhage                           |                                                                          |      2  1.0|
      Hyperplasia, Lymphoid                |                                              3     2              3      |      4  2.8|
      Pigmentation                         |    2                                                                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                   2                                      1               |      2  1.5|
      Pigmentation                         |       3           3                 3           3  3  3  2               |     11  2.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                               X                                          |      2     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    2  2  2  2  3  2  2  2           2  2  2  2        2     2  2  2  2   |     36  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |    2  2  3        3  3     3  3     2  3     2  3  3  3     3  2        2|     35  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 1  3     1        1  1                       1     2  2  1        1      |     20  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                              3                           |      4  2.3|
      Hyperkeratosis                       |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|            |
                                           | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                4                                                         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calvarium, Osteopetrosis             |                                                             3            |      1  3.0|
      Femur, Osteopetrosis                 |                                                             4            |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      X     X     X           X     X                     |     10     |
      Hydrocephalus                        |                            2     2                                       |      4  2.0|
      Necrosis                             |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  2.5|
      Edema                                |                                                                          |      2  2.0|
      Foreign Body                         |    1                                                                     |      2  1.5|
      Infiltration Cellular, Histiocyte    |             1                          2  1                              |      9  1.2|
      Inflammation, Subacute               |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    3           1                          2           2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                         X        X                 X  X                  |     10     |
      Foreign Body                         |                                                                          |      4  1.8|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
      Cataract                             |                               3                                          |      1  3.0|
      Phthisis Bulbi                       |                                                                          |      1     |
      Retina, Atrophy                      |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           |       3  2  3  1     2              1  2     2  2  2  1  2  2  2  4  2   |     34  1.9|
      Hydronephrosis                       |             2  4                                                  3      |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|            |
                                           | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infarct                              |       2                                            2                     |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       | 1  3     2  2     3  1  2  3  2  2  2  2  2  2  1  2  3  2  2  2  2  1  2|     43  1.9|
      Nephropathy                          |    1  2  1  1     1  1  1  1     3     1  1  1  1  1  1  1  1  1  2  1  1|     41  1.2|
      Renal Tubule, Dilatation             |                3                                                         |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  3.0|
      Transitional Epithelium, Hyperplasia | 3  1  3     3        1                    1  2     1        1  1  3  1   |     23  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |             +                                                     +      |   2        |
      Concretion                           |                                                                   4      |      1  4.0|
      Mucosa, Hyperplasia                  |             3                                                     4      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +                                                            |   1        |
      Mucosa, Hyperplasia                  |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           |                                                                   4      |      1  4.0|
      Mucosa, Hyperplasia                  |    3        4                                                     4      |      4  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|             
                                           | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    337.5                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                 X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                 X                 X        X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 3                        |             
      Basophilic Focus                     |    X     X  X        X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                     X     X                              |             
      Cyst                                 |                            X                                             |             
      Eosinophilic Focus                   |    X                 X                          X  X     X     X         |             
      Granuloma                            |                                                       1                  |             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hepatodiaphragmatic Nodule           |                         X  X        X                                X   |             
      Inflammation, Chronic                |                                                                   1      |             
      Mixed Cell Focus                     |    X        X        X        X     X     X                              |             
      Bile Duct, Hyperplasia               |                      1              1              1                     |             
      Centrilobular, Atrophy               |          2                       3                                       |             
      Lobules, Necrosis                    |       2           4              2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                   +                                +|             
      Fat, Hemorrhage                      |    2                                                                     |             
      Fat, Necrosis                        |    3                                   2                                3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1     1        1     1                 1                    1     1|             
      Metaplasia, Hepatocyte               |                                                                          |             
      Acinar Cell, Basophilic Focus        |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                         3                             3                  |             
      Acinar Cell, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         2                                                |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                               2                       1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |             4                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|             
                                           | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    337.5                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1                    1                 2           1  2                  |             
      Inflammation, Subacute               |                   2                                                      |             
      Necrosis                             |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X        X           X  X  X  X              X        X     X      |             
      Angiectasis                          |                   2                                                      |             
      Degeneration, Fatty                  |                                                    1     1        1      |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                        2                                 |             
      Necrosis                             |       1                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2           2              1                       3              1      |             
      Pars Distalis, Cyst                  | X           X     X           X                    X           X         |             
      Pars Distalis, Hyperplasia, Focal    |             1                          1           3           1  3      |             
      Pars Distalis, Hyperplasia           |                   3                                                      |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      3                             1                     |             
      Follicular Cell, Hyperplasia         |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3        3              3     2  2  2  2  4  3  2     3     3  3  3   |             
      Hyperplasia                          |                                        2                                 |             
      Inflammation, Chronic                |                2                                      4                  |             
      Inflammation, Suppurative            |             2              2                                   1  2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                         4|             
                                            __________________________________________________________________________|             
   Vagina                                  |             M                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|             
                                           | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    337.5                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hypercellularity                     |                   2     2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +                                   +                  |             
      Iliac, Ectasia                       |                                                       3                  |             
      Iliac, Hyperplasia, Lymphoid         |                                                       3                  |             
      Mediastinal, Congestion              |       3                                                                  |             
      Mediastinal, Hemorrhage              |    2        2                                                            |             
      Mediastinal, Pigmentation            |    3        3                                                            |             
      Pancreatic, Hemorrhage               |                   2                                                      |             
      Pancreatic, Hyperplasia, Lymphoid    |                   2                                                      |             
      Renal, Hemorrhage                    |                                                       1                  |             
      Renal, Hyperplasia, Lymphoid         |                                                       2                  |             
      Renal, Pigmentation                  |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                                                  |             
      Ectasia                              |                                                    2                     |             
      Hemorrhage                           |                         1                          1                     |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2     3           2           1                                          |             
      Pigmentation                         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3     2        4  2  3  2  2     2  2  2  2  2  2     2     2     2   |             
      Necrosis                             |       2                                                                  |             
      Pigmentation, Hemosiderin            | 3     2     3        3     2  3     3  3  3        3  3     3  3  2  3  2|             
      Lymphoid Follicle, Atrophy           |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       4                                                                  |             
      Hemorrhage                           | 2     2                                                                  |             
      Cortex, Atrophy                      |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    1                 1                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Subacute                        |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|             
                                           | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    337.5                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |    X                 X              X                                X   |             
      Hemorrhage                           |                   2                                                      |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                   1                                                      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |          +     +                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +     +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                                                                        |             
      Edema                                |                                                                          |             
      Foreign Body                         |                               2                             3            |             
      Hemorrhage                           |                   3                                                  1   |             
      Infiltration Cellular, Histiocyte    |                   3     1     1  3           1                       1   |             
      Inflammation, Subacute               |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       X                    X                                         X   |             
      Foreign Body                         |                            2                                             |             
      Mucosa, Hyperplasia                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                       +                     |             
      Cataract                             |                            3                       4                     |             
      Retina, Atrophy                      |                            4                       4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |    3  3     3  2  2  3  3  4  3  3  3  3  2  4  3  3  4  2     4  2      |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |       3                                                                  |             
      Hydronephrosis                       |    2  3     3  1                                1  2  3                  |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                    1                     |             
      Mineralization                       | 3     3  2     1  2  1  3  1  2     2  1  1  2  3  2     1  2  2     2  1|             
      Nephropathy                          | 1  4  2     2  1  1  2  2  1  1     1  1     3  2  3  3  1  1  1  1  1  1|             
      Papilla, Necrosis                    |       2                                                                  |             
      Renal Tubule, Cytoplasmic Alteration |                   3                                                      |             
      Renal Tubule, Dilatation             |       2     2                                3        3           2      |             
      Transitional Epithelium, Hyperplasia | 2  3  3  1  3  3  3  3  3  3  3  2  3  3     4  3  4  4  2  2  3  2      |             
                                            __________________________________________________________________________|             
   Ureter                                  |             +           +                    +                           |             
      Concretion                           |                         2                    3                           |             
      Mucosa, Hyperplasia                  |             3           3                    3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|             
                                           | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    337.5                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              M                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  | 2     2        1  2     2                    3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9|            |
                                           | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    337.5                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X                 X                                 |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X  X        X                                       |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |    X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X  X  X     X     X|     40     |
      Clear Cell Focus                     |       X  X     X     X                       X        X                  |      8     |
      Cyst                                 |                                                                          |      1     |
      Eosinophilic Focus                   |          X           X  X     X              X  X  X                     |     13     |
      Granuloma                            |                1                             1                           |      3  1.0|
      Hematopoietic Cell Proliferation     |                            2                                             |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      6     |
      Bile Duct, Hyperplasia               |                1                                                         |      4  1.0|
      Centrilobular, Atrophy               |                                                                          |      2  2.5|
      Lobules, Necrosis                    |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                                 |   4        |
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                        3                                 |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1     1                       1  1  2  1        2              1         |     15  1.1|
      Metaplasia, Hepatocyte               |                                        X                                 |      1     |
      Acinar Cell, Basophilic Focus        |                            X  X  X                                       |      3     |
      Acinar Cell, Cytoplasmic Alteration  |                            2     3                                       |      4  2.8|
      Acinar Cell, Hyperplasia, Focal      |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                |                                           2                              |      1  2.0|
      Mucosa, Hyperplasia                  |                                           3                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9|            |
                                           | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    337.5                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1        2  1                                                      |      9  1.3|
      Inflammation, Subacute               |                                  2                                       |      2  2.0|
      Necrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    | X  X                       X                 X        X        X  X      |     16     |
      Angiectasis                          |                               3                                          |      2  2.5|
      Degeneration, Fatty                  |          3                    1              2        1                  |      7  1.4|
      Hyperplasia, Focal                   |                               1     1           1     1     1            |      5  1.0|
      Hypertrophy, Focal                   |                      4                                1     1            |      4  2.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |       4  3              4                                2  3            |     10  2.5|
      Pars Distalis, Cyst                  |       X        X     X     X  X     X        X  X  X                     |     15     |
      Pars Distalis, Hyperplasia, Focal    |          1                             2     3  2  2     3  3            |     12  2.1|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                     X                                    |      1     |
      C-Cell, Hyperplasia                  |    1                 1              1  1                                 |      6  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |       2           3                             2           2            |     18  2.6|
      Hyperplasia                          |                                                    2                     |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9|            |
                                           | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    337.5                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          2        2              2           2                           |      6  2.3|
      Inflammation, Suppurative            |                   2        2                                3            |      7  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          X  X            |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                    2                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                    +                     |   7        |
      Iliac, Ectasia                       |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                    2                     |      3  2.0|
      Mediastinal, Pigmentation            |                                                    4                     |      3  3.3|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  1.0|
      Pigmentation                         |    2     2        2                    2     2        3                  |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      2                                            1      |      6  1.8|
      Pigmentation                         |                               3                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2  1  2              2  3           2  3  2  2     2  2  2     2      |     29  2.2|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |    3  2  2  3     3  2  3     2  3  2  3  3  3  3  3  2  3  2  2     3  3|     37  2.7|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           | 3           2                                                  2        2|      6  2.2|
      Cortex, Atrophy                      |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9|            |
                                           | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    337.5                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epithelial Cell, Hyperplasia         |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Ectasia                              |          2                                         1                     |      4  1.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Subacute                        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      4     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                             1            |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3           3                    2                             3     3  3|      7  2.9|
      Edema                                |             2                                                  2     3  2|      4  2.3|
      Foreign Body                         |             3                    3        3              3     2     2   |      8  2.6|
      Hemorrhage                           |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |    1  1        1                          2     1     1     2            |     13  1.5|
      Inflammation, Subacute               |                                                                      2   |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           3        1                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                              X        X                  |      5     |
      Foreign Body                         |                                              2                           |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9|            |
                                           | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    337.5                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                          |      2  3.5|
      Retina, Atrophy                      |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           | 3  3  2           4  3  1     2  3  3  4  3  3  4  3  2  3  3            |     37  2.9|
      Cyst                                 |             X                                                            |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydronephrosis                       |                   2                    1                             2   |     10  2.0|
      Infarct                              |       2                    3              2                              |      3  2.3|
      Inflammation, Suppurative            |                            1                                             |      2  1.0|
      Mineralization                       | 2  1  1  1  1  2  1  2     1     1  1  2  3  2  2  1  2     2  3  2  3   |     41  1.8|
      Nephropathy                          |    1  2  1  2  2  1  1  1  2  1     1  1  1  1  1  1  1  1  1     1  1  1|     44  1.4|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                          2               |      6  2.3|
      Transitional Epithelium, Hyperplasia | 2  2  3        1  3  3     3  1  3  3  3  3  3  4  2  1  4  2  1  2  2   |     43  2.6|
                                            __________________________________________________________________________|____________|
   Ureter                                  |       +                                                                  |   4        |
      Concretion                           |                                                                          |      2  2.5|
      Mucosa, Hyperplasia                  |       1                                                                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia                  |                      1     1     2        2     1                    1   |     12  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|             
                                           | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X              X  X           X     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X              X                 X  X     X              X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X        X     X     X  X  X     X  X     X        X  X  X  X   |             
      Clear Cell Focus                     | X  X  X  X     X  X     X        X  X  X  X  X  X  X     X  X  X  X      |             
      Congestion                           |                            3                                             |             
      Degeneration, Cystic                 |                                        1     1                           |             
      Eosinophilic Focus                   |                                                                      X   |             
      Hepatodiaphragmatic Nodule           | X                 X  X                                   X               |             
      Mixed Cell Focus                     |          X                                                               |             
      Bile Duct, Hyperplasia               | 3  2  2  3  3  2  3  2  1     2  4  2  1  1  1  1  2  2  1  2  1  2  3  2|             
      Centrilobular, Atrophy               |                      3                                               3   |             
      Hepatocyte, Vacuolization Cytoplasmic|             3                                                           3|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                         +        +     +        +   |             
      Fat, Necrosis                        | 3  2                                                  4     4        3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1     3  1           1              2        1  1     2     1  1      |             
      Acinar Cell, Basophilic Focus        |       X                                                                  |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                         3|             
      Acinar Cell, Hyperplasia, Focal      | 3  4           3              4        3     2           3  2        3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      2                                                   |             
      Ulcer                                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                            3                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     3  2                 1  1  3  3                    2  2  2        2|             
      Pericardium, Fibrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|             
                                           | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X  X              X           X        X     X  X           X|             
      Congestion                           |                            4                                             |             
      Cyst                                 |                                              X                           |             
      Degeneration, Fatty                  |                                                    3     1        3  2   |             
      Hemorrhage                           |                                                                      2   |             
      Hyperplasia, Focal                   |          1                                            1                  |             
      Hypertrophy, Focal                   |                      3                       1                       2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2        2           3     2        1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            3                                             |             
      Pars Distalis, Angiectasis           |             3                                1                           |             
      Pars Distalis, Cyst                  | X                 X                                                      |             
      Pars Distalis, Hyperplasia, Focal    |                      3                 2     1     1        2     2     2|             
      Pars Intermedia, Cyst                |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                    X                     |             
      C-Cell, Hyperplasia                  |       1           1     1     1                       2              1   |             
      Follicle, Cyst                       |                                                          X               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | X  X  X  X  X  X  X                 X        X     X  X           X     X|             
      Hypospermia                          | X  X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X  X  X  X   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3           3  3        3              3  3     3  3  4  2  3  3     3   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2     3  2     2     2     2  2        2        2  3           3        2|             
      Inflammation, Suppurative            | 1           3  3     2  2              3  3     2  2     2  2  3     2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     | 2  2  2     2  3  2  3  2           2  2  2  2     3  2        2  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                      3     1  3  1  1              1     2  1        3   |             
      Epithelium, Hyperplasia              |    1                                                  1                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|             
                                           | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +                          +              +              +   |             
      Mediastinal, Hemorrhage              | 4           2                          3                             2   |             
      Mediastinal, Pigmentation            | 4                                      2              3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2                                                  2   |             
      Hemorrhage                           |                                        1  2        1           1         |             
      Hyperplasia, Lymphoid                |                   2           2                                      3   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3        2                                      3                 3   |             
      Hematopoietic Cell Proliferation     |       1                                   2     2           2            |             
      Pigmentation, Hemosiderin            |          3                    2                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                               4                          2           3   |             
      Hyperplasia, Lobular                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                         X                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X                                      X   |             
      Hydrocephalus                        |                               2                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|             
                                           | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Infiltration Cellular, Histiocyte    | 1           1                                                            |             
      Inflammation, Subacute               |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |             1     2     3              1                                 |             
      Fat, Mediastinum, Necrosis           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X        X     X  X                             X           X     X  X   |             
      Foreign Body                         |                                                 1                        |             
      Fungus                               |                X  X                             X                        |             
      Mucosa, Hyperplasia                  |          2        2                             2                        |             
      Mucosa, Metaplasia, Squamous         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                   1           1  1                                       |             
      Mineralization                       |                         1                                            1   |             
      Nephropathy                          | 1  2  1  1  2  2  1  1  1     3  3  2  2  1  2  1  2  1  2  1  1  2  2  2|             
      Renal Tubule, Pigmentation           |                                                                      3   |             
      Transitional Epithelium, Hyperplasia | 1           2  1                       1     2                       1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1|            |
                                           | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                         X                                      X         |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                                X     X  X   |     10     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X     X  X     X  X  X  X  X     X  X  X     X  X  X  X  X  X         |     33     |
      Clear Cell Focus                     | X  X     X  X  X  X  X  X  X           X        X        X  X     X      |     32     |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic                 |                                                                1        1|      4  1.0|
      Eosinophilic Focus                   |                            X        X     X     X              X  X      |      7     |
      Hepatodiaphragmatic Nodule           |                      X                                                   |      5     |
      Mixed Cell Focus                     |             X     X                    X                 X               |      5     |
      Bile Duct, Hyperplasia               | 1  1     2  2  1     2  1  1  1  1  1  1  2  1  2     1  1  2  3  3     3|     45  1.8|
      Centrilobular, Atrophy               |                                                                      2   |      3  2.7|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +                          +  +        +        +  +  +  +  +      |  17        |
      Fat, Necrosis                        | 4  4                             3  2                 3  3  3  3  2      |     14  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2           1  1  1  2              1              1           3   |     18  1.4|
      Acinar Cell, Basophilic Focus        |                                                                          |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      1  3.0|
      Acinar Cell, Hyperplasia, Focal      | 2  2     2     2                          2     2              3         |     16  2.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                       2                  |      1  2.0|
      Ulcer                                |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1|            |
                                           | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |          1  3  2  2     2  2           2           3     3  3     3  1   |     23  2.2|
      Pericardium, Fibrosis                |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    X     X     X     X     X     X              X           X  X  X     X|     19     |
      Congestion                           |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  | 1              1  2        1                                             |      8  1.8|
      Hemorrhage                           |                                                    2                     |      2  2.0|
      Hyperplasia, Focal                   |                            3                          1                  |      4  1.5|
      Hypertrophy, Focal                   |             2     2                                                      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1  1     1     1     2     1     2           3           1     2|     15  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |                                           3        3                     |      4  2.5|
      Pars Distalis, Cyst                  |    X     X                                                           X   |      5     |
      Pars Distalis, Hyperplasia, Focal    | 1  3  1        2  1                    2  3                       2      |     15  1.9|
      Pars Intermedia, Cyst                |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 2     1           1     1  1           1        1              3         |     14  1.3|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |    2                                                                     |      1  2.0|
      Follicular Cell, Hypertrophy         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      | X  X  X     X        X  X           X     X        X              X  X  X|     25     |
      Hypospermia                          | X  X     X  X  X  X  X  X  X  X     X  X  X        X     X  X     X     X|     40     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |             3        3     2        3  4        4                 3      |     20  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1|            |
                                           | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    3                                                                     |      1  3.0|
      Inflammation, Chronic                |    2           2  3              3              2  2  3  2  3  2  2     3|     24  2.3|
      Inflammation, Suppurative            |                2     2     2     3     3                          2      |     19  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |                2           2        2  2  2  3  2  2        2     2  2  2|     28  2.1|
      Hyperplasia, Lymphoid                |                2                                                         |      1  2.0|
      Inflammation, Suppurative            |             2           3        3  3           2  1  2  1               |     17  1.9|
      Epithelium, Hyperplasia              |    1        2  2     1     1                                      1      |      8  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |       2                       4              3                           |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                              +  +|   9        |
      Mediastinal, Hemorrhage              | 3     3                                                                  |      6  2.8|
      Mediastinal, Pigmentation            | 3     2                                                                  |      5  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                2  2  2   |      5  2.0|
      Hemorrhage                           |                                                                          |      4  1.3|
      Hyperplasia, Lymphoid                | 2                                               2                        |      5  2.2|
      Hyperplasia, Plasma Cell             |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              1     2  1                  |      3  1.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            4           3                 2  2            |      8  2.8|
      Hematopoietic Cell Proliferation     |    2  3           2     1  2  2              2           2     2  2      |     14  1.9|
      Pigmentation, Hemosiderin            | 2                 2  2  2        2  2     1        2  2  2     1         |     14  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Cystic                  |          2  1           3        2  2           2     2              2   |     11  2.3|
      Hyperplasia, Lobular                 |                                                          2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                           X                              |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1|            |
                                           | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                         2                                                |      1  2.0|
      Inflammation, Chronic                |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                  X                    X                  |      4     |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Mineralization                       |                   3                                                      |      1  3.0|
      Necrosis                             |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                1     1  1           1  1  1                              |      8  1.0|
      Inflammation, Subacute               |                                  3              2                        |      3  2.3|
      Alveolar Epithelium, Hyperplasia     |             1  2  1                       3  3                 3         |     10  2.0|
      Fat, Mediastinum, Necrosis           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |       X  X           X                 X                    X  X  X      |     15     |
      Foreign Body                         |       2                                2                       1         |      4  1.5|
      Fungus                               |       X  X           X                                                   |      6     |
      Mucosa, Hyperplasia                  |          2                             2                    1            |      6  1.8|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X                                                                  |      1     |
      Inflammation, Suppurative            |             1              1                       1                     |      6  1.0|
      Mineralization                       |                                                                   1      |      3  1.0|
      Nephropathy                          | 1  1  1  1  2  1  2  1  2  3  2     3  1  2  2  1  3  2  2  1  1  1  1  2|     48  1.6|
      Renal Tubule, Pigmentation           |                                                 2                        |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1|            |
                                           | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium, Hyperplasia |                            1        1                             1     1|     10  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|             
                                           | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    84 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X           X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                 X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X  X  X  X     X           X  X  X           X  X  X  X  X      |             
      Clear Cell Focus                     | X  X              X        X        X  X  X     X     X     X  X  X     X|             
      Degeneration, Cystic                 |          3                                                               |             
      Eosinophilic Focus                   |          X              X              X        X        X              X|             
      Hematopoietic Cell Proliferation     |             2                                2                           |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Mixed Cell Focus                     |                                                                X  X      |             
      Bile Duct, Hyperplasia               | 2  1  3     2  1  1        2     3  2  2  3  1  2     1  2  1  2  2     2|             
      Centrilobular, Atrophy               |             2                                3                           |             
      Centrilobular, Necrosis              |                                                                      3   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                       +                             +     +|             
      Accessory Spleen                     |          X                                                               |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |             3                       3                             3     2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  1     4  1     1  1              1        1     3     3  2  1     1|             
      Acinar Cell, Basophilic Focus        |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
      Acinar Cell, Hyperplasia, Focal      |                                  3              3              3  4      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2     2  2  3  1        1     2        3  2        3        2        2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|             
                                           | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    84 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X  X                          X  X  X        X     X  X         |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |    2  1                          3        2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                     1                       1            |             
      Hypertrophy, Focal                   |                                                          1               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |       2  3     1        2  2     2  1  1     2  1           1           1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                 2                        |             
      Pars Distalis, Cyst                  |                         X                       X                        |             
      Pars Distalis, Hyperplasia, Focal    |                      1                    3     1                        |             
      Pars Intermedia, Angiectasis         |             2                                                           3|             
      Pars Intermedia, Cyst                |                                                       X                  |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Nervosa, Gliosis                |             2                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 | X                                X                          X            |             
      C-Cell, Hyperplasia                  |       1                          1  3                 3                  |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | X  X  X        X  X     X  X     X     X  X  X           X  X  X  X     X|             
      Hypospermia                          | X  X  X  X  X  X  X     X  X           X  X  X  X        X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3     3                       2  3  2     4                 3|             
      Inflammation, Chronic                |       2     2  2        1     2     2     2  2  2  2        2           3|             
      Inflammation, Suppurative            |             2                                         4                 1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |    2  2  2  2  2        2        2  2  2  2  3  2     2  2        2     2|             
      Inflammation, Suppurative            | 2  1  1  2     2  1              2  3  3  2           3        3  1      |             
      Epithelium, Hyperplasia              |       2                 1                    1           2               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|             
                                           | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    84 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                                           3                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                     1     4           1        1         |             
      Seminiferous Tubule, Atrophy         |                                           3                    3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +                                            +     +  +     +|             
      Mediastinal, Hemorrhage              |                                                          3     3  3     3|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                          4     3  3     3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                           3|             
      Hemorrhage                           |                         1                 2              1     2         |             
      Hyperplasia, Lymphoid                |                2                                               2         |             
      Pigmentation                         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  3                                       |             
      Pigmentation                         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                              3        3        3         |             
      Hematopoietic Cell Proliferation     | 2     2     3     2     2           2        2           2               |             
      Pigmentation, Hemosiderin            | 2              2     2           1     1           2  3                 1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          3                       3  2                 2                  |             
      Hyperplasia, Lobular                 |                2                       2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                     X        X              X            |             
      Foreign Body                         |                            3                                             |             
      Inflammation, Suppurative            |             3              3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X                       X                                       |             
      Hydrocephalus                        |                2                 2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|             
                                           | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    84 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3        3                    3                     |             
      Edema                                |                      2        2                                          |             
      Foreign Body                         |                      2     1  2                    3                     |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |             1           1                                                |             
      Inflammation, Subacute               |                      2     1        1                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Fat, Mediastinum, Necrosis           |                                                             4            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                           X                              |             
      Foreign Body                         |                                           2                              |             
      Fungus                               |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Cataract                             |       4                                                                  |             
      Retina, Atrophy                      |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Cyst                                 |                X                                                         |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                1                 1     1        2        1               |             
      Mineralization                       |    1        1                    1  1     1                              |             
      Nephropathy                          | 2  3  1  2  2  3  2     1  1  1  3  3  2  2  2  3  1  2  2  3  2  1  1  2|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                  2                                       |             
      Renal Tubule, Pigmentation           |          2  3                                3                           |             
      Transitional Epithelium, Hyperplasia |    1  1        1                 1           1  1        1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3|            |
                                           | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    84 MG/KG                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                         X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                    X                        |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                      1  2|      2  1.5|
      Basophilic Focus                     | X           X  X        X  X     X  X     X  X  X  X  X  X  X  X  X  X  X|     33     |
      Clear Cell Focus                     | X           X  X                          X  X     X        X  X  X     X|     23     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |             X                                   X              X  X      |     10     |
      Hematopoietic Cell Proliferation     |       2                                                                  |      3  2.0|
      Hepatodiaphragmatic Nodule           |                                     X                                    |      2     |
      Mixed Cell Focus                     |                                           X                              |      3     |
      Bile Duct, Hyperplasia               | 2           1  1  3  3  2        1  1  1  1  2  3  1  1  1  1  1  3  2  1|     39  1.7|
      Centrilobular, Atrophy               |                   2  3                                                   |      4  2.5|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|          2                                                               |      1  2.0|
      Lobules, Necrosis                    |                      2        1                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +  +              +  +                    +           +  +      |  14        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Hemorrhage                      |                            2                                             |      1  2.0|
      Fat, Necrosis                        | 4     3  3  4              4  2                    2           3  2      |     13  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  2  1     1     3     1  3                    1  1  3     1     2     1|     26  1.7|
      Acinar Cell, Basophilic Focus        |                X                                                         |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                      3                                                   |      1  3.0|
      Acinar Cell, Hyperplasia, Focal      |             3  2                    4     2     3           2  2         |     11  2.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3|            |
                                           | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    84 MG/KG                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  2  2        2  3  3  1     2     1     2  1  1     2     1            |     27  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    X           X        X        X     X     X  X     X     X     X  X   |     19     |
      Congestion                           |                                                    3                     |      1  3.0|
      Degeneration, Fatty                  |                                                 2        1               |      6  1.8|
      Hematopoietic Cell Proliferation     |       2                                                                  |      1  2.0|
      Hyperplasia, Focal                   | 1  1                       1           1        1     1                  |      8  1.0|
      Hypertrophy, Focal                   |                                                    2                     |      2  1.5|
      Necrosis                             |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2              1                 2        3        1  1               |     18  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Focal    | 2     1  1        1                       3              2        1  1   |     11  1.5|
      Pars Intermedia, Angiectasis         |                                                                          |      2  2.5|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Intermedia, Hyperplasia         |                                                       1                  |      1  1.0|
      Pars Nervosa, Gliosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                   X      |      4     |
      C-Cell, Hyperplasia                  |       1        1                                            1     1     1|      9  1.4|
      Follicle, Cyst                       |                   X                                X  X                  |      3     |
      Follicular Cell, Hypertrophy         |             2                          2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      | X  X        X  X  X  X              X  X  X  X  X  X  X     X     X  X  X|     33     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3|            |
                                           | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    84 MG/KG                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hypospermia                          | X  X        X  X                    X  X  X  X  X  X  X     X  X  X  X  X|     34     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 3  4              3     3  3     2           2     3           4  3      |     17  2.9|
      Inflammation, Chronic                |    3                    2                 2  3              2     2      |     18  2.1|
      Inflammation, Suppurative            | 2  4     2        2  2  2  2                 3     3        2  4     2   |     15  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     | 2           3  2     3           3     2  2  2              2  3  2  2   |     28  2.2|
      Inflammation, Suppurative            |                   3  2     1     3  3                                1   |     19  2.1|
      Epithelium, Hyperplasia              | 3                                   2     2        1                     |      8  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Hyperplasia       |                   1                                                      |      5  1.6|
      Seminiferous Tubule, Atrophy         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +           +  +                    +     +              +     +   |  15        |
      Mediastinal, Hemorrhage              | 2                                               2              2     2   |      8  2.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                           2                              |      1  2.0|
      Mediastinal, Pigmentation            | 3                    3                          2              2     2   |      9  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                2         |      3  2.3|
      Hemorrhage                           | 1                                         1           2        2         |      8  1.5|
      Hyperplasia, Lymphoid                |    3                                         2                           |      4  2.3|
      Pigmentation                         |                                  2     2                                 |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      2                                                   |      2  2.5|
      Pigmentation                         |                                              3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |    X                                                                     |      1     |
      Fibrosis                             | 4                 4  3  3                                      2         |      8  3.1|
      Hematopoietic Cell Proliferation     |       4        2           2           2     2        2  2               |     15  2.2|
      Pigmentation, Hemosiderin            | 3  3     2           1           2  2        2                           |     15  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05099-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/07/95  
Route: GAVAGE                                                                                                     Time: 00:41:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3|            |
                                           | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    84 MG/KG                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _______________________________________