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TDMS Study 05101-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Brookhaven                                              METHYL BROMIDE                                    DATE: 09/13/94       
EXPERIMENT: 05101 TEST: 01                                                                                     TIME: 19:07:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: Y-01200-87            ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 04148B       
PATHOLOGIST: S. EUSTIS                       M. GARY RILEY                                                     CAS: 74-83-9         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Brookhaven                                              METHYL BROMIDE                                    DATE: 09/13/94      
EXPERIMENT: 05101 TEST: 01                                                                                     TIME: 19:07:13      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: Y-01200-87            ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 04148B      
PATHOLOGIST: S. EUSTIS                       M. GARY RILEY                                                     CAS: 74-83-9        
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Brookhaven                                              METHYL BROMIDE                                    DATE: 09/13/94       
EXPERIMENT: 05101 TEST: 01                                                                                     TIME: 19:07:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: Y-01200-87            ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 04148B       
PATHOLOGIST: S. EUSTIS                       M. GARY RILEY                                                     CAS: 74-83-9         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF METHYL BROMIDE
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             All Organs                    Hemangiosarcoma or Hemangioma
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Lung                          Alveolar/Bronchiolar Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Carcinoma or Adenoma
                             All Organs                    Histiocytic Sarcoma
 
              ====================================================================================================
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/70 (3%)    2/69 (3%)    1/72 (1%)    0/82 (0%)  |  1/70 (1%)    1/72 (1%)    0/72 (0%)    0/72 (0%)  |
|ADJUSTED (b)           |   4.4%         5.4%         2.5%         0.0%      |   2.8%         2.1%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    2/37 (5%)    1/40 (3%)    0/16 (0%)  |  1/36 (3%)    0/41 (0%)    0/45 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   603          727 (T)      727 (T)      ---       |   727 (T)      577          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.292N     P=0.666      P=0.511N     P=0.443N   |  P=0.296N     P=0.738N     P=0.455N     P=0.479N   |
|INCIDENTAL TUMOR       |  P=0.200N     P=0.690N     P=0.457N     P=0.186N   |  P=0.269N     P=0.669N     P=0.455N     P=0.479N   |
|LOGISTIC REGRESSION    |  P=0.250N     P=0.677      P=0.498N     P=0.355N   |  P=0.302N     P=0.752N     P=0.455N     P=0.479N   |
|COCHRAN-ARMITAGE       |  P=0.117N                                          |  P=0.302N                                          |
|FISHER EXACT           |               P=0.685      P=0.489N     P=0.210N   |               P=0.745N     P=0.493N     P=0.493N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/70 (0%)    2/69 (3%)    0/72 (0%)    0/82 (0%)  |  0/70 (0%)    0/72 (0%)    0/72 (0%)    1/72 (1%)  |
|ADJUSTED (b)           |   0.0%         5.1%         0.0%         0.0%      |   0.0%         0.0%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    1/37 (3%)    0/40 (0%)    0/16 (0%)  |  0/36 (0%)    0/41 (0%)    0/45 (0%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          695          ---          ---       |   ---          ---          ---          727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.537N     P=0.224        (e)          (e)      |  P=0.216        (e)          (e)        P=0.521    |
|INCIDENTAL TUMOR       |  P=0.481N     P=0.251        (e)          (e)      |  P=0.216        (e)          (e)        P=0.521    |
|LOGISTIC REGRESSION    |  P=0.510N     P=0.224        (e)          (e)      |  P=0.216        (e)          (e)        P=0.521    |
|COCHRAN-ARMITAGE       |  P=0.340N                                          |  P=0.217                                           |
|FISHER EXACT           |               P=0.245        (e)          (e)      |                 (e)          (e)        P=0.507    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/70 (3%)    4/69 (6%)    1/72 (1%)    0/82 (0%)  |  1/70 (1%)    1/72 (1%)    0/72 (0%)    1/72 (1%)  |
|ADJUSTED (b)           |   4.4%        10.3%         2.5%         0.0%      |   2.8%         2.1%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    3/37 (8%)    1/40 (3%)    0/16 (0%)  |  1/36 (3%)    0/41 (0%)    0/45 (0%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   603          695          727 (T)      ---       |   727 (T)      577          ---          727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.205N     P=0.308      P=0.511N     P=0.443N   |  P=0.688      P=0.738N     P=0.455N     P=0.738N   |
|INCIDENTAL TUMOR       |  P=0.132N     P=0.348      P=0.457N     P=0.186N   |  P=0.673N     P=0.669N     P=0.455N     P=0.738N   |
|LOGISTIC REGRESSION    |  P=0.169N     P=0.313      P=0.498N     P=0.355N   |  P=0.680      P=0.752N     P=0.455N     P=0.738N   |
|COCHRAN-ARMITAGE       |  P=0.061N                                          |  P=0.680                                           |
|FISHER EXACT           |               P=0.333      P=0.489N     P=0.210N   |               P=0.745N     P=0.493N     P=0.745N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/70 (0%)    0/69 (0%)    2/72 (3%)    0/82 (0%)  |  0/70 (0%)    0/72 (0%)    0/72 (0%)    1/72 (1%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.9%         0.0%      |   0.0%         0.0%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    0/37 (0%)    1/40 (3%)    0/16 (0%)  |  0/36 (0%)    0/41 (0%)    0/45 (0%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          690          ---       |   ---          ---          ---          727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.651        (e)        P=0.232        (e)      |  P=0.216        (e)          (e)        P=0.521    |
|INCIDENTAL TUMOR       |  P=0.682        (e)        P=0.185        (e)      |  P=0.216        (e)          (e)        P=0.521    |
|LOGISTIC REGRESSION    |  P=0.672        (e)        P=0.234        (e)      |  P=0.216        (e)          (e)        P=0.521    |
|COCHRAN-ARMITAGE       |  P=0.655N                                          |  P=0.217                                           |
|FISHER EXACT           |                 (e)        P=0.255        (e)      |                 (e)          (e)        P=0.507    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/70 (26%)  22/69 (32%)  17/72 (24%)   7/82 (9%)  |  6/70 (9%)    8/72 (11%)   7/72 (10%)   5/72 (7%)  |
|ADJUSTED (b)           |  41.4%        52.7%        40.2%        34.8%      |  16.7%        18.4%        15.6%        11.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  1/10 (10%)   3/9 (33%)    0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 15/40 (38%)  18/37 (49%)  15/40 (38%)   4/16 (25%) |  6/36 (17%)   7/41 (17%)   7/45 (16%)   4/40 (10%) |
|FIRST INCIDENCE (DAYS) |   464 (I)      464 (I)      520          542       |   727 (T)      428          727 (T)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.425N     P=0.180      P=0.501N     P=0.599    |  P=0.290N     P=0.487      P=0.567N     P=0.429N   |
|INCIDENTAL TUMOR       |  P=0.203N     P=0.198      P=0.546N     P=0.337N   |  P=0.287N     P=0.469      P=0.567N     P=0.391N   |
|LOGISTIC REGRESSION    |  P=0.159N     P=0.208      P=0.519N     P=0.339N   |  P=0.315N     P=0.429      P=0.567N     P=0.475N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.315N                                          |
|FISHER EXACT           |               P=0.269      P=0.462N     P=0.004N** |               P=0.411      P=0.522      P=0.480N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/70 (21%)  16/69 (23%)  10/72 (14%)   4/82 (5%)  |  4/70 (6%)    4/72 (6%)    2/72 (3%)    1/72 (1%)  |
|ADJUSTED (b)           |  32.9%        37.1%        22.4%        21.9%      |  10.7%         9.8%         4.4%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  1/10 (10%)   0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 10/40 (25%)  10/37 (27%)   6/40 (15%)   3/16 (19%) |  3/36 (8%)    4/41 (10%)   2/45 (4%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   465 (I)      566          481          542       |   708          727 (T)      727 (T)      727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.160N     P=0.401      P=0.205N     P=0.339N   |  P=0.098N     P=0.576N     P=0.246N     P=0.156N   |
|INCIDENTAL TUMOR       |  P=0.019N*    P=0.491      P=0.187N     P=0.115N   |  P=0.102N     P=0.639      P=0.302N     P=0.179N   |
|LOGISTIC REGRESSION    |  P=0.031N*    P=0.463      P=0.181N     P=0.148N   |  P=0.105N     P=0.610N     P=0.264N     P=0.168N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.109N                                          |
|FISHER EXACT           |               P=0.482      P=0.169N     P=0.002N** |               P=0.625N     P=0.327N     P=0.174N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/70 (21%)  17/69 (25%)  10/72 (14%)   4/82 (5%)  |  4/70 (6%)    4/72 (6%)    2/72 (3%)    1/72 (1%)  |
|ADJUSTED (b)           |  32.9%        38.3%        22.4%        21.9%      |  10.7%         9.8%         4.4%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  1/10 (10%)   0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 10/40 (25%)  10/37 (27%)   6/40 (15%)   3/16 (19%) |  3/36 (8%)    4/41 (10%)   2/45 (4%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   465 (I)      442          481          542       |   708          727 (T)      727 (T)      727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.142N     P=0.328      P=0.205N     P=0.339N   |  P=0.098N     P=0.576N     P=0.246N     P=0.156N   |
|INCIDENTAL TUMOR       |  P=0.009N**   P=0.404      P=0.187N     P=0.115N   |  P=0.102N     P=0.639      P=0.302N     P=0.179N   |
|LOGISTIC REGRESSION    |  P=0.027N*    P=0.349      P=0.181N     P=0.148N   |  P=0.105N     P=0.610N     P=0.264N     P=0.168N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.109N                                          |
|FISHER EXACT           |               P=0.402      P=0.169N     P=0.002N** |               P=0.625N     P=0.327N     P=0.174N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/70 (43%)  34/69 (49%)  26/72 (36%)   9/82 (11%) | 10/70 (14%)  12/72 (17%)   8/72 (11%)   6/72 (8%)  |
|ADJUSTED (b)           |  62.2%        72.1%        56.3%        45.6%      |  26.9%        28.0%        17.8%        14.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   3/9 (33%)    0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 22/40 (55%)  24/37 (65%)  20/40 (50%)   6/16 (38%) |  9/36 (25%)  11/41 (27%)   8/45 (18%)   5/40 (13%) |
|FIRST INCIDENCE (DAYS) |   464 (I)      464 (I)      481          542       |   708          428          727 (T)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.112N     P=0.173      P=0.313N     P=0.290N   |  P=0.081N     P=0.535      P=0.217N     P=0.152N   |
|INCIDENTAL TUMOR       |  P=0.003N**   P=0.204      P=0.326N     P=0.045N*  |  P=0.082N     P=0.470      P=0.250N     P=0.145N   |
|LOGISTIC REGRESSION    |  P=0.003N**   P=0.176      P=0.280N     P=0.046N*  |  P=0.094N     P=0.462      P=0.248N     P=0.183N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.101N                                          |
|FISHER EXACT           |               P=0.278      P=0.258N     P<0.001N** |               P=0.437      P=0.376N     P=0.196N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/70 (43%)  35/69 (51%)  26/72 (36%)   9/82 (11%) | 10/70 (14%)  12/72 (17%)   8/72 (11%)   6/72 (8%)  |
|ADJUSTED (b)           |  62.2%        72.7%        56.3%        45.6%      |  26.9%        28.0%        17.8%        14.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   3/9 (33%)    0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 22/40 (55%)  24/37 (65%)  20/40 (50%)   6/16 (38%) |  9/36 (25%)  11/41 (27%)   8/45 (18%)   5/40 (13%) |
|FIRST INCIDENCE (DAYS) |   464 (I)      442          481          542       |   708          428          727 (T)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.100N     P=0.136      P=0.313N     P=0.290N   |  P=0.081N     P=0.535      P=0.217N     P=0.152N   |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.156      P=0.326N     P=0.045N*  |  P=0.082N     P=0.470      P=0.250N     P=0.145N   |
|LOGISTIC REGRESSION    |  P=0.003N**   P=0.133      P=0.280N     P=0.046N*  |  P=0.094N     P=0.462      P=0.248N     P=0.183N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.101N                                          |
|FISHER EXACT           |               P=0.224      P=0.258N     P<0.001N** |               P=0.437      P=0.376N     P=0.196N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/70 (17%)   9/68 (13%)  10/72 (14%)   4/82 (5%)  |  3/70 (4%)    2/72 (3%)    1/72 (1%)    7/72 (10%) |
|ADJUSTED (b)           |  28.3%        23.2%        23.4%        18.7%      |   8.3%         4.7%         2.0%        17.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    1/9 (11%)    0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 10/40 (25%)   8/37 (22%)   8/40 (20%)   2/16 (13%) |  3/36 (8%)    1/41 (2%)    0/45 (0%)    6/40 (15%) |
|FIRST INCIDENCE (DAYS) |   653          465 (I)      481          485       |   727 (T)      643          611          658       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.462N     P=0.389N     P=0.413N     P=0.440N   |  P=0.033 *    P=0.449N     P=0.236N     P=0.200    |
|INCIDENTAL TUMOR       |  P=0.168N     P=0.364N     P=0.457N     P=0.172N   |  P=0.039 *    P=0.392N     P=0.196N     P=0.181    |
|LOGISTIC REGRESSION    |  P=0.292N     P=0.369N     P=0.418N     P=0.304N   |  P=0.030 *    P=0.475N     P=0.261N     P=0.171    |
|COCHRAN-ARMITAGE       |  P=0.013N*                                         |  P=0.034 *                                         |
|FISHER EXACT           |               P=0.345N     P=0.381N     P=0.014N*  |               P=0.487N     P=0.299N     P=0.175    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/70 (3%)    8/68 (12%)   6/72 (8%)    1/82 (1%)  |  1/70 (1%)    2/72 (3%)    1/72 (1%)    1/72 (1%)  |
|ADJUSTED (b)           |   4.5%        20.2%        14.1%         6.3%      |   2.7%         4.9%         2.2%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     1/10 (10%)   0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  1/40 (3%)    6/37 (16%)   5/40 (13%)   1/16 (6%)  |  0/36 (0%)    2/41 (5%)    1/45 (2%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   484          625          465 (I)      727 (T)   |   720          727 (T)      727 (T)      727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.486N     P=0.040 *    P=0.139      P=0.714    |  P=0.522N     P=0.542      P=0.713N     P=0.740N   |
|INCIDENTAL TUMOR       |  P=0.280N     P=0.035 *    P=0.155      P=0.539N   |  P=0.529N     P=0.411      P=0.715      P=0.729    |
|LOGISTIC REGRESSION    |  P=0.335N     P=0.040 *    P=0.140      P=0.681N   |  P=0.536N     P=0.522      P=0.726N     P=0.755N   |
|COCHRAN-ARMITAGE       |  P=0.065N                                          |  P=0.530N                                          |
|FISHER EXACT           |               P=0.044 *    P=0.147      P=0.441N   |               P=0.511      P=0.745N     P=0.745N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/70 (20%)  15/68 (22%)  15/72 (21%)   5/82 (6%)  |  4/70 (6%)    4/72 (6%)    2/72 (3%)    7/72 (10%) |
|ADJUSTED (b)           |  32.1%        36.9%        34.2%        24.5%      |  10.8%         9.4%         4.1%        17.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    1/9 (11%)    1/10 (10%)   0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 11/40 (28%)  12/37 (32%)  12/40 (30%)   3/16 (19%) |  3/36 (8%)    3/41 (7%)    1/45 (2%)    6/40 (15%) |
|FIRST INCIDENCE (DAYS) |   484          465 (I)      465 (I)      485       |   720          643          611          658       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.432N     P=0.405      P=0.496      P=0.454N   |  P=0.155      P=0.577N     P=0.249N     P=0.319    |
|INCIDENTAL TUMOR       |  P=0.099N     P=0.414      P=0.470      P=0.126N   |  P=0.167      P=0.614N     P=0.270N     P=0.268    |
|LOGISTIC REGRESSION    |  P=0.208N     P=0.426      P=0.499      P=0.289N   |  P=0.141      P=0.613N     P=0.276N     P=0.279    |
|COCHRAN-ARMITAGE       |  P=0.003N**                                        |  P=0.152                                           |
|FISHER EXACT           |               P=0.465      P=0.534      P=0.009N** |               P=0.625N     P=0.327N     P=0.283    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/70 (3%)    0/71 (0%)    1/72 (1%)    3/70 (4%)  |
|ADJUSTED (b)           |                                                    |   5.6%         0.0%         2.2%         7.5%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|                                                    |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |                                                    |  2/36 (6%)    0/40 (0%)    1/45 (2%)    3/40 (8%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   727 (T)      ---          727 (T)      727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.193      P=0.215N     P=0.422N     P=0.548    |
|INCIDENTAL TUMOR       |                                                    |  P=0.193      P=0.215N     P=0.422N     P=0.548    |
|LOGISTIC REGRESSION    |                                                    |  P=0.193      P=0.215N     P=0.422N     P=0.548    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.181                                           |
|FISHER EXACT           |                                                    |               P=0.245N     P=0.489N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/63 (0%)    0/63 (0%)    0/67 (0%)    0/59 (0%)  |  5/68 (7%)    4/70 (6%)    2/69 (3%)    1/67 (1%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  13.5%         9.3%         4.2%         2.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/34 (0%)    0/32 (0%)    0/37 (0%)    0/13 (0%)  |  4/36 (11%)   2/41 (5%)    0/44 (0%)    1/39 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   720          643          681          727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.072N     P=0.434N     P=0.153N     P=0.088N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.061N     P=0.621N     P=0.281N     P=0.104N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.056N     P=0.477N     P=0.172N     P=0.098N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.080N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.482N     P=0.214N     P=0.108N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/63 (0%)    0/63 (0%)    0/67 (0%)    0/59 (0%)  |  6/68 (9%)    4/70 (6%)    2/69 (3%)    1/67 (1%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  16.2%         9.3%         4.2%         2.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/34 (0%)    0/32 (0%)    0/37 (0%)    0/13 (0%)  |  5/36 (14%)   2/41 (5%)    0/44 (0%)    1/39 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   720          643          681          727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.047N*    P=0.306N     P=0.087N     P=0.048N*  |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.039N*    P=0.469N     P=0.167N     P=0.057N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.037N*    P=0.346N     P=0.099N     P=0.054N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.053N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.354N     P=0.132N     P=0.060N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/70 (0%)    0/69 (0%)    0/72 (0%)    0/81 (0%)  |  1/70 (1%)    1/72 (1%)    2/72 (3%)    1/72 (1%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   1.8%         2.4%         4.4%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  1/9 (11%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    0/37 (0%)    0/40 (0%)    0/16 (0%)  |  0/36 (0%)    1/41 (2%)    2/45 (4%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   464 (I)      727 (T)      727 (T)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.641N     P=0.734N     P=0.564      P=0.755    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.621N     P=0.734N     P=0.564      P=0.701N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.637N     P=0.755N     P=0.524      P=0.754N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.634N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.745N     P=0.511      P=0.745N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Thymoma NOS                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/61 (0%)    0/55 (0%)    0/61 (0%)    0/48 (0%)  |  0/65 (0%)    2/61 (3%)    0/64 (0%)    0/61 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         5.4%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/33 (0%)    0/28 (0%)    0/34 (0%)    0/10 (0%)  |  0/33 (0%)    1/31 (3%)    0/38 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          643          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.369N     P=0.238        (e)          (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.336N     P=0.306        (e)          (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.378N     P=0.217        (e)          (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.379N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.232        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/69 (1%)    0/68 (0%)    0/71 (0%)    0/77 (0%)  |  2/69 (3%)    4/71 (6%)    2/71 (3%)    2/71 (3%)  |
|ADJUSTED (b)           |   2.5%         0.0%         0.0%         0.0%      |   5.6%         9.8%         4.4%         5.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  1/40 (3%)    0/37 (0%)    0/40 (0%)    0/16 (0%)  |  2/36 (6%)    4/41 (10%)   2/45 (4%)    2/40 (5%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          ---          ---       |   727 (T)      727 (T)      727 (T)      727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.612N     P=0.516N     P=0.500N     P=0.682N   |  P=0.418N     P=0.398      P=0.612N     P=0.657N   |
|INCIDENTAL TUMOR       |  P=0.612N     P=0.516N     P=0.500N     P=0.682N   |  P=0.418N     P=0.398      P=0.612N     P=0.657N   |
|LOGISTIC REGRESSION    |  P=0.612N     P=0.516N     P=0.500N     P=0.682N   |  P=0.418N     P=0.398      P=0.612N     P=0.657N   |
|COCHRAN-ARMITAGE       |  P=0.459N                                          |  P=0.433N                                          |
|FISHER EXACT           |               P=0.504N     P=0.493N     P=0.473N   |               P=0.354      P=0.679N     P=0.679N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/69 (1%)    0/68 (0%)    0/71 (0%)    0/77 (0%)  |  3/69 (4%)    4/71 (6%)    2/71 (3%)    2/71 (3%)  |
|ADJUSTED (b)           |   2.5%         0.0%         0.0%         0.0%      |   8.3%         9.8%         4.4%         5.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  1/40 (3%)    0/37 (0%)    0/40 (0%)    0/16 (0%)  |  3/36 (8%)    4/41 (10%)   2/45 (4%)    2/40 (5%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          ---          ---       |   727 (T)      727 (T)      727 (T)      727 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.612N     P=0.516N     P=0.500N     P=0.682N   |  P=0.311N     P=0.571      P=0.399N     P=0.452N   |
|INCIDENTAL TUMOR       |  P=0.612N     P=0.516N     P=0.500N     P=0.682N   |  P=0.311N     P=0.571      P=0.399N     P=0.452N   |
|LOGISTIC REGRESSION    |  P=0.612N     P=0.516N     P=0.500N     P=0.682N   |  P=0.311N     P=0.571      P=0.399N     P=0.452N   |
|COCHRAN-ARMITAGE       |  P=0.459N                                          |  P=0.328N                                          |
|FISHER EXACT           |               P=0.504N     P=0.493N     P=0.473N   |               P=0.516      P=0.486N     P=0.486N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/70 (1%)    2/72 (3%)    3/72 (4%)    0/72 (0%)  |
|ADJUSTED (b)           |                                                    |   2.8%         4.1%         6.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|                                                    |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |                                                    |  1/36 (3%)    1/41 (2%)    3/45 (7%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   727 (T)      463          727 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.241N     P=0.538      P=0.388      P=0.479N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.254N     P=0.504      P=0.388      P=0.479N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.250N     P=0.515      P=0.388      P=0.479N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.251N                                          |
|FISHER EXACT           |                                                    |               P=0.511      P=0.321      P=0.493N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/70 (0%)    0/69 (0%)    1/72 (1%)    1/82 (1%)  |  1/70 (1%)    2/72 (3%)    2/72 (3%)    1/72 (1%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.5%         5.9%      |   1.8%         4.5%         4.4%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  1/9 (11%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    0/37 (0%)    1/40 (3%)    0/16 (0%)  |  0/36 (0%)    1/41 (2%)    2/45 (4%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          727 (T)      722       |   464 (I)      505          727 (T)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.129        (e)        P=0.500      P=0.325    |  P=0.519N     P=0.535      P=0.564      P=0.755    |
|INCIDENTAL TUMOR       |  P=0.187        (e)        P=0.500      P=0.455    |  P=0.510N     P=0.501      P=0.564      P=0.701N   |
|LOGISTIC REGRESSION    |  P=0.133        (e)        P=0.500      P=0.332    |  P=0.517N     P=0.509      P=0.524      P=0.754N   |
|COCHRAN-ARMITAGE       |  P=0.345                                           |  P=0.515N                                          |
|FISHER EXACT           |                 (e)        P=0.507      P=0.539    |               P=0.511      P=0.511      P=0.745N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/70 (0%)    1/69 (1%)    1/72 (1%)    2/82 (2%)  |  1/70 (1%)    2/72 (3%)    2/72 (3%)    2/72 (3%)  |
|ADJUSTED (b)           |   0.0%         2.7%         2.5%        11.8%      |   1.8%         4.5%         4.4%         4.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  1/9 (11%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    1/37 (3%)    1/40 (3%)    1/16 (6%)  |  0/36 (0%)    1/41 (2%)    2/45 (4%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          727 (T)      727 (T)      722       |   464 (I)      505          727 (T)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.036 *    P=0.484      P=0.500      P=0.075    |  P=0.496      P=0.535      P=0.564      P=0.506    |
|INCIDENTAL TUMOR       |  P=0.055      P=0.484      P=0.500      P=0.126    |  P=0.504      P=0.501      P=0.564      P=0.576    |
|LOGISTIC REGRESSION    |  P=0.039 *    P=0.484      P=0.500      P=0.077    |  P=0.495      P=0.509      P=0.524      P=0.509    |
|COCHRAN-ARMITAGE       |  P=0.242                                           |  P=0.498                                           |
|FISHER EXACT           |               P=0.496      P=0.507      P=0.289    |               P=0.511      P=0.511      P=0.511    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/70 (0%)    0/69 (0%)    1/72 (1%)    0/82 (0%)  |  5/70 (7%)    2/72 (3%)    1/72 (1%)    1/72 (1%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.5%         0.0%      |  12.0%         4.9%         2.2%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  0/40 (0%)    0/37 (0%)    1/40 (3%)    0/16 (0%)  |  2/36 (6%)    2/41 (5%)    1/45 (2%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          727 (T)      ---       |   500          727 (T)      727 (T)      655       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.794        (e)        P=0.500        (e)      |  P=0.113N     P=0.186N     P=0.071N     P=0.099N   |
|INCIDENTAL TUMOR       |  P=0.794        (e)        P=0.500        (e)      |  P=0.118N     P=0.218N     P=0.140N     P=0.107N   |
|LOGISTIC REGRESSION    |  P=0.794        (e)        P=0.500        (e)      |  P=0.089N     P=0.199N     P=0.084N     P=0.048N*  |
|COCHRAN-ARMITAGE       |  P=0.758N                                          |  P=0.116N                                          |
|FISHER EXACT           |                 (e)        P=0.507        (e)      |               P=0.209N     P=0.098N     P=0.098N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/70 (3%)    2/69 (3%)    8/72 (11%)   2/82 (2%)  |  9/70 (13%)   6/72 (8%)   10/72 (14%)   8/72 (11%) |
|ADJUSTED (b)           |   4.5%         4.4%        17.9%        11.5%      |  19.9%        14.1%        21.2%        16.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  1/40 (3%)    1/37 (3%)    5/40 (13%)   1/16 (6%)  |  3/36 (8%)    5/41 (12%)   8/45 (18%)   3/40 (8%)  |
|FIRST INCIDENCE (DAYS) |   484          420          543          714       |   430          622          640          233       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.214      P=0.666      P=0.055      P=0.391    |  P=0.553N     P=0.239N     P=0.519N     P=0.449N   |
|INCIDENTAL TUMOR       |  P=0.469N     P=0.694      P=0.099      P=0.665    |  P=0.436N     P=0.217N     P=0.342      P=0.328N   |
|LOGISTIC REGRESSION    |  P=0.376      P=0.689      P=0.052      P=0.477    |  P=0.552      P=0.235N     P=0.601      P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.444N                                          |  P=0.559                                           |
|FISHER EXACT           |               P=0.685      P=0.053      P=0.628N   |               P=0.273N     P=0.527      P=0.475N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/70 (3%)    2/69 (3%)    7/72 (10%)   2/82 (2%)  |  4/70 (6%)    4/72 (6%)    9/72 (13%)   7/72 (10%) |
|ADJUSTED (b)           |   4.5%         4.4%        15.6%        11.5%      |   8.8%         9.3%        19.1%        14.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  1/40 (3%)    1/37 (3%)    4/40 (10%)   1/16 (6%)  |  1/36 (3%)    3/41 (7%)    7/45 (16%)   3/40 (8%)  |
|FIRST INCIDENCE (DAYS) |   484          420          543          714       |   430          622          640          233       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.228      P=0.666      P=0.091      P=0.391    |  P=0.234      P=0.591N     P=0.215      P=0.310    |
|INCIDENTAL TUMOR       |  P=0.442N     P=0.694      P=0.159      P=0.665    |  P=0.342      P=0.545N     P=0.061      P=0.443    |
|LOGISTIC REGRESSION    |  P=0.398      P=0.689      P=0.152      P=0.477    |  P=0.215      P=0.620N     P=0.162      P=0.281    |
|COCHRAN-ARMITAGE       |  P=0.457N                                          |  P=0.223                                           |
|FISHER EXACT           |               P=0.685      P=0.090      P=0.628N   |               P=0.625N     P=0.133      P=0.283    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/70 (43%)  28/69 (41%)  28/72 (39%)  10/82 (12%) | 16/70 (23%)  18/72 (25%)  17/72 (24%)  18/72 (25%) |
|ADJUSTED (b)           |  66.4%        67.7%        63.4%        47.4%      |  42.0%        38.3%        33.5%        42.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  1/10 (10%)   3/9 (33%)    0/10 (0%)    0/0        |  0/9 (0%)     0/10 (0%)    1/10 (10%)   0/8 (0%)   |
|TERMINAL (d)           | 25/40 (63%)  24/37 (65%)  24/40 (60%)   6/16 (38%) | 14/36 (39%)  13/41 (32%)  12/45 (27%)  16/40 (40%) |
|FIRST INCIDENCE (DAYS) |   464 (I)      464 (I)      481          485       |   707          428          465 (I)      578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.291N     P=0.554      P=0.431N     P=0.340N   |  P=0.489      P=0.579      P=0.385N     P=0.555    |
|INCIDENTAL TUMOR       |  P=0.047N*    P=0.560N     P=0.453N     P=0.057N   |  P=0.510      P=0.475      P=0.477N     P=0.527    |
|LOGISTIC REGRESSION    |  P=0.063N     P=0.547N     P=0.438N     P=0.090N   |  P=0.454      P=0.492      P=0.476N     P=0.462    |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.467                                           |
|FISHER EXACT           |               P=0.460N     P=0.378N     P<0.001N** |               P=0.459      P=0.537      P=0.459    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 PPM       33 PPM       100 PPM   |   CONTROL      10 PPM       33 PPM       100 PPM   |
|                       |   NEURO        NEURO        NEURO        NEURO     |   NEURO        NEURO        NEURO        NEURO     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 17/70 (24%)  28/69 (41%)  23/72 (32%)   9/82 (11%) | 17/70 (24%)  15/72 (21%)  15/72 (21%)  14/72 (19%) |
|ADJUSTED (b)           |  36.4%        60.5%        46.5%        43.3%      |  36.1%        32.6%        31.9%        28.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  1/10 (10%)   0/9 (0%)     1/10 (10%)   0/0        |  1/9 (11%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           | 11/40 (28%)  19/37 (51%)  14/40 (35%)   5/16 (31%) |  7/36 (19%)  11/41 (27%)  13/45 (29%)   6/40 (15%) |
|FIRST INCIDENCE (DAYS) |   465 (I)      420          465 (I)      496       |   430          428          640          233       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.520      P=0.021 *    P=0.186      P=0.305    |  P=0.324N     P=0.313N     P=0.215N     P=0.292N   |
|INCIDENTAL TUMOR       |  P=0.023N*    P=0.016 *    P=0.238      P=0.389N   |  P=0.230N     P=0.413N     P=0.535N     P=0.224N   |
|LOGISTIC REGRESSION    |  P=0.142N     P=0.015 *    P=0.303      P=0.588    |  P=0.338N     P=0.338N     P=0.277N     P=0.296N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.332N                                          |
|FISHER EXACT           |               P=0.030 *    P=0.204      P=0.025N*  |               P=0.385N     P=0.385N     P=0.310N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 39/70 (56%)  44/69 (64%)  40/72 (56%)  17/82 (21%) | 28/70 (40%)  31/72 (43%)  29/72 (40%)  27/72 (38%) |
|ADJUSTED (b)           |  79.4%        87.9%        78.3%        72.9%      |  59.2%        61.4%        55.6%        55.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/0        |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/0        |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   3/9 (33%)    1/10 (10%)   0/0        |  1/9 (11%)    0/10 (0%)    1/10 (10%)   0/8 (0%)   |
|TERMINAL (d)           | 30/40 (75%)  31/37 (84%)  29/40 (73%)  10/16 (63%) | 17/36 (47%)  22/41 (54%)  22/45 (49%)  19/40 (48%) |
|FIRST INCIDENCE (DAYS) |   464 (I)      420          465 (I)      485       |   430          428          465 (I)      233       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.532      P=0.104      P=0.493      P=0.394    |  P=0.315N     P=0.555N     P=0.276N     P=0.364N   |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.096      P=0.582      P=0.110N   |  P=0.202N     P=0.403      P=0.536      P=0.329N   |
|LOGISTIC REGRESSION    |  P=0.022N*    P=0.083      P=0.487N     P=0.227N   |  P=0.333N     P=0.477      P=0.399N     P=0.433N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.333N                                          |
|FISHER EXACT           |               P=0.213      P=0.560N     P<0.001N** |               P=0.421      P=0.555      P=0.447N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05101 TEST: 01                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   183  464
          Female interim sacrifices(days): 183  464
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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