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TDMS Study 05132-06 Pathology Tables

NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16




       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          58           58           58           58                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4           16           15           17                                     
    Moribund Sacrifice                                 8           28           26           27                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36            4            6            4                                     

  Animals Examined Microscopically                    58           58           58           58                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (51)         (46)         (44)         (44)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Large, Colon                             (57)         (55)         (52)         (50)                                   
      Infarct                                          1 (2%)                                                                       
      Mesothelium, Inflammation, Chronic Active        2 (4%)                                                                       
   Intestine Large, Rectum                            (58)         (58)         (52)         (51)                                   
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
   Intestine Large, Cecum                             (57)         (52)         (50)         (46)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Lymphoid Tissue, Hyperplasia, Lymphoid                        1 (2%)                                                          
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
   Intestine Small, Duodenum                          (55)         (49)         (49)         (45)                                   
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                    1 (2%)                                             
   Intestine Small, Jejunum                           (56)         (47)         (49)         (45)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Perforation                                      1 (2%)                                                                       
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Intestine Small, Ileum                             (56)         (49)         (49)         (45)                                   
      Mesothelium, Inflammation, Chronic Active        2 (4%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)       1 (2%)                                             
   Liver                                              (58)         (58)         (57)         (57)                                   
      Angiectasis                                      1 (2%)      13 (22%)      8 (14%)      5 (9%)                                
      Basophilic Focus                                                           1 (2%)       3 (5%)                                
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Eosinophilic Focus                               5 (9%)      14 (24%)     16 (28%)     12 (21%)                               
      Fatty Change                                                  3 (5%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 3 (5%)      19 (33%)     13 (23%)     16 (28%)                               
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct                                          2 (3%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct, Chronic                                                                        1 (2%)                                
      Infiltration Cellular, Mixed Cell                9 (16%)     12 (21%)     12 (21%)      4 (7%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mixed Cell Focus                                 3 (5%)       1 (2%)                    2 (4%)                                
      Necrosis, Coagulative, Multifocal                4 (7%)      12 (21%)      8 (14%)      8 (14%)                               
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Centrilobular, Necrosis                                       3 (5%)       1 (2%)                                             
      Hepatocyte, Karyomegaly                                                                 1 (2%)                                
      Serosa, Fibrosis                                 1 (2%)       1 (2%)                                                          
   Mesentery                                          (10)         (14)         (7)          (7)                                    
      Angiectasis                                      1 (10%)                                                                      
      Cyst                                                          1 (7%)                                                          
      Hyperplasia, Lymphoid                                                      1 (14%)                                            
      Mineralization                                                             1 (14%)                                            
      Fat, Hemorrhage                                               1 (7%)                                                          
      Fat, Necrosis                                    8 (80%)      9 (64%)      6 (86%)      6 (86%)                               
      Mesothelium, Inflammation, Chronic Active        1 (10%)                                                                      
   Pancreas                                           (58)         (57)         (54)         (57)                                   
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Acinus, Atrophy                                  1 (2%)       1 (2%)       3 (6%)                                             
      Acinus, Vacuolization Cytoplasmic                                                       1 (2%)                                
      Duct, Ectasia                                                              1 (2%)                                             
   Salivary Glands                                    (58)         (58)         (57)         (58)                                   
      Infiltration Cellular, Mononuclear Cell         23 (40%)      9 (16%)     13 (23%)      3 (5%)                                
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
   Stomach, Forestomach                               (58)         (58)         (57)         (57)                                   
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia                          4 (7%)                                 4 (7%)                                
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Stomach, Glandular                                 (58)         (58)         (55)         (55)                                   
      Mineralization                                                1 (2%)                                                          
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Tooth                                              (2)                                    (3)                                    
      Dysplasia                                        1 (50%)                                2 (67%)                               
      Peridontal Tissue, Inflammation, Suppurative                                            1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (58)         (57)         (58)                                   
      Cardiomyopathy                                   2 (3%)                                                                       
      Polyarteritis                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (57)         (57)         (57)                                   
      Cyst                                                          1 (2%)       1 (2%)                                             
      Degeneration, Fatty                                                                     1 (2%)                                
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
      Capsule, Hyperplasia                            50 (86%)     55 (96%)     52 (91%)     50 (88%)                               
      Capsule, Mineralization                                       1 (2%)                                                          
      X-Zone, Vacuolization Cytoplasmic                2 (3%)       2 (4%)       4 (7%)       3 (5%)                                
   Adrenal Medulla                                    (58)         (57)         (57)         (56)                                   
      Angiectasis                                                                1 (2%)                                             
   Islets, Pancreatic                                 (58)         (55)         (54)         (57)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (56)         (55)         (54)         (56)                                   
      Pars Distalis, Angiectasis                                                              2 (4%)                                
      Pars Distalis, Congestion                        2 (4%)                                 2 (4%)                                
      Pars Distalis, Cyst                              3 (5%)                                 1 (2%)                                
      Pars Distalis, Hyperplasia                       6 (11%)      3 (5%)       2 (4%)       5 (9%)                                
   Thyroid Gland                                      (58)         (58)         (56)         (56)                                   
      Inflammation, Focal                              1 (2%)       1 (2%)                                                          
      Polyarteritis                                                              1 (2%)                                             
      Ultimobranchial Cyst                             2 (3%)       2 (3%)       3 (5%)       2 (4%)                                
      Follicle, Cyst                                   2 (3%)       2 (3%)                                                          
      Follicular Cell, Hyperplasia                     2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (51)         (51)         (47)         (48)                                   
      Ectasia                                                       1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell          2 (4%)       1 (2%)       1 (2%)                                             
   Ovary                                              (57)         (57)         (55)         (56)                                   
      Abscess                                                       1 (2%)                                                          
      Atrophy                                          2 (4%)       4 (7%)       5 (9%)       2 (4%)                                
      Congestion                                                    1 (2%)       2 (4%)       1 (2%)                                
      Cyst                                            14 (25%)     28 (49%)     16 (29%)     20 (36%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Pigmentation, Hemosiderin, Cholesterol           1 (2%)                                                                       
      Pigmentation, Lipofuscin                                      1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Polyarteritis                                    1 (2%)                                                                       
   Uterus                                             (58)         (58)         (55)         (57)                                   
      Dilatation                                       3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                27 (47%)     27 (47%)     28 (51%)     31 (54%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (58)         (56)         (57)                                   
      Hyperplasia, Erythrocyte                                      2 (3%)       2 (4%)                                             
      Hyperplasia, Neutrophil                          2 (3%)       1 (2%)       1 (2%)       2 (4%)                                
   Lymph Node                                         (5)          (6)          (5)          (6)                                    
      Axillary, Hyperplasia, Lymphoid                                            1 (20%)                                            
      Iliac, Angiectasis                                            1 (17%)                                                         
      Iliac, Hyperplasia, Lymphoid                                  1 (17%)      1 (20%)                                            
      Iliac, Inflammation, Chronic Active                           1 (17%)                                                         
      Lumbar, Hyperplasia, Lymphoid                                              1 (20%)                                            
      Pancreatic, Hyperplasia, Histiocytic             1 (20%)                                                                      
      Pancreatic, Hyperplasia, Lymphoid                             1 (17%)      1 (20%)      1 (17%)                               
      Renal, Hemorrhage                                             1 (17%)                   2 (33%)                               
      Renal, Hyperplasia, Lymphoid                                  1 (17%)                                                         
   Lymph Node, Bronchial                              (47)         (44)         (49)         (46)                                   
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                    1 (2%)       2 (4%)       3 (7%)                                
      Hyperplasia, Histiocytic                                      1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       5 (11%)      3 (6%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (46)         (39)         (43)         (38)                                   
      Hemorrhage                                                    1 (3%)       1 (2%)                                             
      Hyperplasia, Histiocytic                                                   1 (2%)       1 (3%)                                
      Hyperplasia, Lymphoid                            2 (4%)       2 (5%)       2 (5%)       1 (3%)                                
      Hyperplasia, Plasma Cell                                      1 (3%)                    1 (3%)                                
      Inflammation                                     1 (2%)                                                                       
   Lymph Node, Mesenteric                             (53)         (50)         (51)         (53)                                   
      Angiectasis                                                                             1 (2%)                                
      Hemorrhage                                       2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
      Hyperplasia, Histiocytic                         1 (2%)       1 (2%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                         5 (10%)      4 (8%)       2 (4%)                                
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Lymph Node, Mediastinal                            (35)         (42)         (43)         (36)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                 1 (2%)       2 (6%)                                
      Hematopoietic Cell Proliferation                                                        1 (3%)                                
      Hemorrhage                                                                 4 (9%)                                             
      Hyperplasia, Histiocytic                                      2 (5%)                                                          
      Hyperplasia, Lymphoid                            2 (6%)       2 (5%)       5 (12%)                                            
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Inflammation                                     1 (3%)                                                                       
      Pigmentation, Hemosiderin                                     1 (2%)       1 (2%)                                             
   Spleen                                             (58)         (58)         (56)         (57)                                   
      Hematopoietic Cell Proliferation                20 (34%)     43 (74%)     45 (80%)     44 (77%)                               
      Hyperplasia, Lymphoid                            2 (3%)                    3 (5%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                                                1 (2%)                                
      Pigmentation, Melanin                                         1 (2%)                                                          
      Capsule, Hematocyst                                                        1 (2%)                                             
   Thymus                                             (56)         (52)         (49)         (48)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Necrosis                                                                   4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (56)         (54)         (56)                                   
      Hyperplasia                                                   1 (2%)       2 (4%)       2 (4%)                                
   Skin                                               (57)         (58)         (57)         (58)                                   
      Congestion                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)         (58)         (57)         (58)                                   
      Fracture Healed                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (58)         (56)         (58)                                   
      Compression                                      1 (2%)       1 (2%)                    1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                  24 (41%)     10 (17%)     15 (27%)     25 (43%)                               
      Ventricle, Dilatation                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (58)         (57)         (57)                                   
      Congestion                                       2 (3%)                    1 (2%)                                             
      Embolus, Focal                                                1 (2%)                                                          
      Hemorrhage                                       3 (5%)       5 (9%)       6 (11%)      3 (5%)                                
      Inflammation, Chronic                                                      2 (4%)                                             
      Pigmentation, Hemosiderin                                     2 (3%)                    3 (5%)                                
      Pigmentation, Hemoglobin                                                   1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)                    2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       1 (2%)       2 (4%)       3 (5%)                                
      Interstitium, Infiltration Cellular, Mixed                                                                                    
          Cell                                                      3 (5%)       1 (2%)                                             
   Nose                                               (57)         (58)         (55)         (55)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative                                            1 (2%)                                
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (6)          (4)          (8)                                    
      Hyperplasia                                                   2 (33%)      3 (75%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (57)         (57)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Infarct, Chronic                                              2 (3%)       1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell          5 (9%)       3 (5%)       4 (7%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)       1 (2%)                                
      Nephropathy                                                   1 (2%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                    1 (2%)                                
      Polyarteritis                                                              1 (2%)                                             
      Glomerulus, Amyloid Deposition                                                          1 (2%)                                
      Pelvis, Infiltration Cellular, Mononuclear                                                                                    
          Cell                                                                   1 (2%)                                             
      Renal Tubule, Dilatation                         1 (2%)                                                                       
   Urinary Bladder                                    (55)         (53)         (53)         (46)                                   
      Hyperplasia, Lymphoid                            4 (7%)       2 (4%)       2 (4%)       1 (2%)                                
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Metaplasia, Squamous                                                       1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          58           58           58           58                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4           13           20           20                                     
    Moribund Sacrifice                                 6           24           26           27                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           11            2            1                                     

  Animals Examined Microscopically                    58           58           58           58                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (51)         (43)         (41)         (37)                                   
      Inflammation, Chronic Active                                                            1 (3%)                                
   Intestine Large, Colon                             (57)         (52)         (51)         (49)                                   
      Diverticulum                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (56)         (50)         (44)         (44)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)                                                          
   Intestine Small, Ileum                             (56)         (48)         (45)         (46)                                   
      Peyer's Patch, Inflammation, Chronic Active      1 (2%)                                                                       
   Liver                                              (58)         (58)         (58)         (58)                                   
      Angiectasis                                                   7 (12%)     15 (26%)     15 (26%)                               
      Basophilic Focus                                 1 (2%)       1 (2%)       5 (9%)       4 (7%)                                
      Clear Cell Focus                                 1 (2%)                    2 (3%)       1 (2%)                                
      Eosinophilic Focus                               1 (2%)       6 (10%)     10 (17%)      7 (12%)                               
      Fatty Change                                     6 (10%)      1 (2%)       1 (2%)       1 (2%)                                
      Granuloma                                                                               1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)       5 (9%)                                             
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Infarct                                          1 (2%)       6 (10%)      2 (3%)       5 (9%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       5 (9%)       4 (7%)       5 (9%)                                
      Mixed Cell Focus                                 3 (5%)       3 (5%)       6 (10%)      3 (5%)                                
      Necrosis, Coagulative, Multifocal                5 (9%)       4 (7%)      13 (22%)     12 (21%)                               
      Thrombosis                                                    1 (2%)       3 (5%)                                             
      Bile Duct, Hyperplasia                                        1 (2%)                                                          
      Centrilobular, Necrosis                                                    1 (2%)       1 (2%)                                
      Hepatocyte, Regeneration                                                                1 (2%)                                
   Mesentery                                          (2)          (3)          (2)          (7)                                    
      Angiectasis                                                                             1 (14%)                               
      Fat, Hemorrhage                                                                         2 (29%)                               
      Fat, Necrosis                                    1 (50%)      2 (67%)      1 (50%)      3 (43%)                               
   Pancreas                                           (58)         (58)         (56)         (55)                                   
      Granuloma                                        1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Ectasia                                                              1 (2%)                                             
   Salivary Glands                                    (58)         (58)         (58)         (58)                                   
      Infiltration Cellular, Mononuclear Cell         11 (19%)      9 (16%)      1 (2%)       6 (10%)                               
   Stomach, Forestomach                               (58)         (58)         (56)         (56)                                   
      Foreign Body                                     1 (2%)                                                                       
      Granuloma                                        1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Squamous                                                      1 (2%)                                             
      Inflammation, Focal                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                    1 (2%)                                
      Epithelium, Hyperplasia                          2 (3%)       3 (5%)       2 (4%)       4 (7%)                                
      Serosa, Inflammation                             1 (2%)                                                                       
   Stomach, Glandular                                 (58)         (58)         (56)         (55)                                   
      Foreign Body                                                                            1 (2%)                                
      Necrosis                                                                                2 (4%)                                
   Tooth                                              (2)          (2)          (4)          (8)                                    
      Dysplasia                                        1 (50%)      1 (50%)                   3 (38%)                               
      Inflammation, Suppurative                        1 (50%)                   4 (100%)     5 (63%)                               
      Peridontal Tissue, Proliferation Connective                                                                                   
          Tissue                                                    1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (58)         (58)         (58)                                   
      Cardiomyopathy                                   2 (3%)                    2 (3%)                                             
      Fibrosis                                                                                1 (2%)                                
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (58)         (57)         (58)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      1 (2%)       3 (5%)                                                          
      Capsule, Hyperplasia                            35 (60%)     30 (52%)     31 (54%)     22 (38%)                               
   Islets, Pancreatic                                 (58)         (58)         (56)         (55)                                   
      Hyperplasia                                      2 (3%)       1 (2%)       8 (14%)      3 (5%)                                
   Pituitary Gland                                    (57)         (53)         (53)         (54)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
      Pars Intermedia, Hemorrhage                                   1 (2%)                                                          
   Thyroid Gland                                      (58)         (58)         (57)         (57)                                   
      Ultimobranchial Cyst                                          1 (2%)       2 (4%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (2)                                                 
      Infiltration Cellular, Mononuclear Cell                                    1 (50%)                                            
      Necrosis                                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (58)         (58)         (58)                                   
      Granuloma Sperm                                                                         1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
   Preputial Gland                                    (58)         (58)         (56)         (58)                                   
      Atrophy                                                                    1 (2%)                                             
      Ectasia                                          2 (3%)       6 (10%)      2 (4%)       1 (2%)                                
      Infiltration Cellular, Mononuclear Cell          7 (12%)      7 (12%)      8 (14%)      3 (5%)                                
      Inflammation, Chronic                            5 (9%)       5 (9%)       4 (7%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       4 (7%)      10 (18%)      3 (5%)                                
   Prostate                                           (56)         (54)         (54)         (53)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
   Seminal Vesicle                                    (58)         (57)         (57)         (54)                                   
      Dilatation                                       4 (7%)       1 (2%)       2 (4%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                    2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
   Testes                                             (58)         (58)         (58)         (58)                                   
      Atrophy, Focal                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (58)         (57)         (57)                                   
      Hyperplasia, Neutrophil                          2 (3%)       1 (2%)       3 (5%)       2 (4%)                                
   Lymph Node                                         (3)          (1)          (2)                                                 
      Iliac, Hemorrhage                                                          1 (50%)                                            
      Iliac, Hyperplasia, Lymphoid                     1 (33%)                                                                      
      Iliac, Hyperplasia, Plasma Cell                                            2 (100%)                                           
      Iliac, Pigmentation, Hemosiderin                                           1 (50%)                                            
      Renal, Hyperplasia, Lymphoid                     1 (33%)                                                                      
   Lymph Node, Bronchial                              (42)         (42)         (43)         (33)                                   
      Hemorrhage                                                    2 (5%)                                                          
      Hyperplasia, Lymphoid                                         2 (5%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Lymph Node, Mandibular                             (44)         (37)         (38)         (42)                                   
      Congestion                                                    1 (3%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Histiocytic                                      1 (3%)       2 (5%)                                             
      Hyperplasia, Lymphoid                                         1 (3%)       1 (3%)                                             
      Hyperplasia, Plasma Cell                                                                1 (2%)                                
      Pigmentation, Hemosiderin                                     2 (5%)       1 (3%)                                             
   Lymph Node, Mesenteric                             (57)         (52)         (51)         (50)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)       2 (4%)       2 (4%)                                             
      Hyperplasia, Histiocytic                         2 (4%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mediastinal                            (37)         (39)         (40)         (36)                                   
      Congestion                                                    1 (3%)                                                          
      Hematopoietic Cell Proliferation                                           1 (3%)                                             
      Hemorrhage                                                                 3 (8%)       2 (6%)                                
      Hyperplasia, Histiocytic                                                   1 (3%)       2 (6%)                                
      Hyperplasia, Lymphoid                            1 (3%)                    1 (3%)                                             
   Spleen                                             (58)         (58)         (56)         (56)                                   
      Atrophy                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                16 (28%)     36 (62%)     46 (82%)     45 (80%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Pigmentation, Melanin                                         2 (3%)                                                          
   Thymus                                             (51)         (49)         (44)         (46)                                   
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (58)         (57)         (58)         (58)                                   
      Acanthosis                                       1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Inflammation, Chronic                            2 (3%)       5 (9%)       2 (3%)       3 (5%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Ulcer                                            2 (3%)       4 (7%)                    5 (9%)                                
      Prepuce, Acanthosis                              1 (2%)       2 (4%)                                                          
      Prepuce, Inflammation, Chronic                                2 (4%)                                                          
      Prepuce, Inflammation, Suppurative                                                      1 (2%)                                
      Prepuce, Pigmentation, Melanin                                1 (2%)                                                          
      Prepuce, Ulcer                                                1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Congestion                                                         1 (2%)                                
      Subcutaneous Tissue, Hemorrhage                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)         (58)         (58)         (58)                                   
      Fracture                                                                                1 (2%)                                
      Sternum, Developmental Malformation                                                     2 (3%)                                
      Sternum, Fracture Healed                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (58)         (58)         (58)                                   
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Mineralization                                  28 (48%)     19 (33%)     15 (26%)     30 (52%)                               
      Necrosis, Liquifactive                           2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (57)         (58)         (56)         (56)                                   
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Exudate, Mucopurulent                                                      2 (4%)       2 (4%)                                
      Hemorrhage                                                                              1 (2%)                                
      Metaplasia, Squamous                                                                    2 (4%)                                
   Lung                                               (58)         (58)         (58)         (58)                                   
      Congestion                                                    2 (3%)       5 (9%)       1 (2%)                                
      Crystals                                                      1 (2%)                                                          
      Hemorrhage                                       6 (10%)      4 (7%)       2 (3%)       1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)       1 (2%)                                
      Alveolus, Hemorrhage, Multifocal                 1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte      4 (7%)       5 (9%)       1 (2%)       1 (2%)                                
      Interstitium, Infiltration Cellular, Mixed                                                                                    
          Cell                                         1 (2%)                                                                       
   Nose                                               (58)         (57)         (56)         (57)                                   
      Inflammation, Suppurative                        1 (2%)                    3 (5%)       1 (2%)                                
      Proliferation Connective Tissue, Multifocal                   1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative                                            1 (2%)                                
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration                                   1 (2%)                                                                       
      Respiratory Epithelium, Degeneration                                                    1 (2%)                                
      Vomeronasal Organ, Hypertrophy                                             1 (2%)                                             
   Trachea                                            (57)         (57)         (56)         (56)                                   
      Cytoplasmic Alteration                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (2)                                                 
      Degeneration, Diffuse                                                      1 (50%)                                            
      Phthisis Bulbi                                                             1 (50%)                                            
      Retinal Detachment                                                         1 (50%)                                            
      Cornea, Inflammation, Chronic                                              1 (50%)                                            
   Harderian Gland                                    (7)          (10)         (5)          (7)                                    
      Hyperplasia                                                                1 (20%)      1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (58)         (58)                                   
      Cyst                                             2 (3%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell          3 (5%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    2 (3%)                                             
      Inflammation, Suppurative                        2 (3%)                                                                       
      Nephropathy                                     35 (60%)     15 (26%)     10 (17%)     19 (33%)                               
      Bilateral, Pelvis, Dilatation                                 1 (2%)       1 (2%)                                             
      Renal Tubule, Dilatation                                      4 (7%)      22 (38%)     46 (79%)                               
      Renal Tubule, Karyomegaly                        1 (2%)       2 (3%)      14 (24%)     38 (66%)                               
   Urinary Bladder                                    (58)         (53)         (53)         (52)                                   
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (3%)                    2 (4%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
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