Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2268

TDMS Study 05132-06 Pathology Tables

NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16




       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          58           58           58           58                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4           16           15           17                                     
    Moribund Sacrifice                                 8           28           26           27                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36            4            6            4                                     

  Animals Examined Microscopically                    58           58           58           58                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (51)         (46)         (44)         (44)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Large, Colon                             (57)         (55)         (52)         (50)                                   
      Infarct                                          1 (2%)                                                                       
      Mesothelium, Inflammation, Chronic Active        2 (4%)                                                                       
   Intestine Large, Rectum                            (58)         (58)         (52)         (51)                                   
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
   Intestine Large, Cecum                             (57)         (52)         (50)         (46)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Lymphoid Tissue, Hyperplasia, Lymphoid                        1 (2%)                                                          
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
   Intestine Small, Duodenum                          (55)         (49)         (49)         (45)                                   
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                    1 (2%)                                             
   Intestine Small, Jejunum                           (56)         (47)         (49)         (45)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Perforation                                      1 (2%)                                                                       
      Mesothelium, Inflammation, Chronic Active        1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Intestine Small, Ileum                             (56)         (49)         (49)         (45)                                   
      Mesothelium, Inflammation, Chronic Active        2 (4%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)       1 (2%)                                             
   Liver                                              (58)         (58)         (57)         (57)                                   
      Angiectasis                                      1 (2%)      13 (22%)      8 (14%)      5 (9%)                                
      Basophilic Focus                                                           1 (2%)       3 (5%)                                
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Eosinophilic Focus                               5 (9%)      14 (24%)     16 (28%)     12 (21%)                               
      Fatty Change                                                  3 (5%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 3 (5%)      19 (33%)     13 (23%)     16 (28%)                               
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct                                          2 (3%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct, Chronic                                                                        1 (2%)                                
      Infiltration Cellular, Mixed Cell                9 (16%)     12 (21%)     12 (21%)      4 (7%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mixed Cell Focus                                 3 (5%)       1 (2%)                    2 (4%)                                
      Necrosis, Coagulative, Multifocal                4 (7%)      12 (21%)      8 (14%)      8 (14%)                               
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Centrilobular, Necrosis                                       3 (5%)       1 (2%)                                             
      Hepatocyte, Karyomegaly                                                                 1 (2%)                                
      Serosa, Fibrosis                                 1 (2%)       1 (2%)                                                          
   Mesentery                                          (10)         (14)         (7)          (7)                                    
      Angiectasis                                      1 (10%)                                                                      
      Cyst                                                          1 (7%)                                                          
      Hyperplasia, Lymphoid                                                      1 (14%)                                            
      Mineralization                                                             1 (14%)                                            
      Fat, Hemorrhage                                               1 (7%)                                                          
      Fat, Necrosis                                    8 (80%)      9 (64%)      6 (86%)      6 (86%)                               
      Mesothelium, Inflammation, Chronic Active        1 (10%)                                                                      
   Pancreas                                           (58)         (57)         (54)         (57)                                   
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Acinus, Atrophy                                  1 (2%)       1 (2%)       3 (6%)                                             
      Acinus, Vacuolization Cytoplasmic                                                       1 (2%)                                
      Duct, Ectasia                                                              1 (2%)                                             
   Salivary Glands                                    (58)         (58)         (57)         (58)                                   
      Infiltration Cellular, Mononuclear Cell         23 (40%)      9 (16%)     13 (23%)      3 (5%)                                
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
   Stomach, Forestomach                               (58)         (58)         (57)         (57)                                   
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia                          4 (7%)                                 4 (7%)                                
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Stomach, Glandular                                 (58)         (58)         (55)         (55)                                   
      Mineralization                                                1 (2%)                                                          
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Tooth                                              (2)                                    (3)                                    
      Dysplasia                                        1 (50%)                                2 (67%)                               
      Peridontal Tissue, Inflammation, Suppurative                                            1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (58)         (57)         (58)                                   
      Cardiomyopathy                                   2 (3%)                                                                       
      Polyarteritis                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (57)         (57)         (57)                                   
      Cyst                                                          1 (2%)       1 (2%)                                             
      Degeneration, Fatty                                                                     1 (2%)                                
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
      Capsule, Hyperplasia                            50 (86%)     55 (96%)     52 (91%)     50 (88%)                               
      Capsule, Mineralization                                       1 (2%)                                                          
      X-Zone, Vacuolization Cytoplasmic                2 (3%)       2 (4%)       4 (7%)       3 (5%)                                
   Adrenal Medulla                                    (58)         (57)         (57)         (56)                                   
      Angiectasis                                                                1 (2%)                                             
   Islets, Pancreatic                                 (58)         (55)         (54)         (57)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (56)         (55)         (54)         (56)                                   
      Pars Distalis, Angiectasis                                                              2 (4%)                                
      Pars Distalis, Congestion                        2 (4%)                                 2 (4%)                                
      Pars Distalis, Cyst                              3 (5%)                                 1 (2%)                                
      Pars Distalis, Hyperplasia                       6 (11%)      3 (5%)       2 (4%)       5 (9%)                                
   Thyroid Gland                                      (58)         (58)         (56)         (56)                                   
      Inflammation, Focal                              1 (2%)       1 (2%)                                                          
      Polyarteritis                                                              1 (2%)                                             
      Ultimobranchial Cyst                             2 (3%)       2 (3%)       3 (5%)       2 (4%)                                
      Follicle, Cyst                                   2 (3%)       2 (3%)                                                          
      Follicular Cell, Hyperplasia                     2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (51)         (51)         (47)         (48)                                   
      Ectasia                                                       1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell          2 (4%)       1 (2%)       1 (2%)                                             
   Ovary                                              (57)         (57)         (55)         (56)                                   
      Abscess                                                       1 (2%)                                                          
      Atrophy                                          2 (4%)       4 (7%)       5 (9%)       2 (4%)                                
      Congestion                                                    1 (2%)       2 (4%)       1 (2%)                                
      Cyst                                            14 (25%)     28 (49%)     16 (29%)     20 (36%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Pigmentation, Hemosiderin, Cholesterol           1 (2%)                                                                       
      Pigmentation, Lipofuscin                                      1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Polyarteritis                                    1 (2%)                                                                       
   Uterus                                             (58)         (58)         (55)         (57)                                   
      Dilatation                                       3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                27 (47%)     27 (47%)     28 (51%)     31 (54%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (58)         (56)         (57)                                   
      Hyperplasia, Erythrocyte                                      2 (3%)       2 (4%)                                             
      Hyperplasia, Neutrophil                          2 (3%)       1 (2%)       1 (2%)       2 (4%)                                
   Lymph Node                                         (5)          (6)          (5)          (6)                                    
      Axillary, Hyperplasia, Lymphoid                                            1 (20%)                                            
      Iliac, Angiectasis                                            1 (17%)                                                         
      Iliac, Hyperplasia, Lymphoid                                  1 (17%)      1 (20%)                                            
      Iliac, Inflammation, Chronic Active                           1 (17%)                                                         
      Lumbar, Hyperplasia, Lymphoid                                              1 (20%)                                            
      Pancreatic, Hyperplasia, Histiocytic             1 (20%)                                                                      
      Pancreatic, Hyperplasia, Lymphoid                             1 (17%)      1 (20%)      1 (17%)                               
      Renal, Hemorrhage                                             1 (17%)                   2 (33%)                               
      Renal, Hyperplasia, Lymphoid                                  1 (17%)                                                         
   Lymph Node, Bronchial                              (47)         (44)         (49)         (46)                                   
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                    1 (2%)       2 (4%)       3 (7%)                                
      Hyperplasia, Histiocytic                                      1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       5 (11%)      3 (6%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (46)         (39)         (43)         (38)                                   
      Hemorrhage                                                    1 (3%)       1 (2%)                                             
      Hyperplasia, Histiocytic                                                   1 (2%)       1 (3%)                                
      Hyperplasia, Lymphoid                            2 (4%)       2 (5%)       2 (5%)       1 (3%)                                
      Hyperplasia, Plasma Cell                                      1 (3%)                    1 (3%)                                
      Inflammation                                     1 (2%)                                                                       
   Lymph Node, Mesenteric                             (53)         (50)         (51)         (53)                                   
      Angiectasis                                                                             1 (2%)                                
      Hemorrhage                                       2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
      Hyperplasia, Histiocytic                         1 (2%)       1 (2%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                         5 (10%)      4 (8%)       2 (4%)                                
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Lymph Node, Mediastinal                            (35)         (42)         (43)         (36)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                 1 (2%)       2 (6%)                                
      Hematopoietic Cell Proliferation                                                        1 (3%)                                
      Hemorrhage                                                                 4 (9%)                                             
      Hyperplasia, Histiocytic                                      2 (5%)                                                          
      Hyperplasia, Lymphoid                            2 (6%)       2 (5%)       5 (12%)                                            
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Inflammation                                     1 (3%)                                                                       
      Pigmentation, Hemosiderin                                     1 (2%)       1 (2%)                                             
   Spleen                                             (58)         (58)         (56)         (57)                                   
      Hematopoietic Cell Proliferation                20 (34%)     43 (74%)     45 (80%)     44 (77%)                               
      Hyperplasia, Lymphoid                            2 (3%)                    3 (5%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                                                1 (2%)                                
      Pigmentation, Melanin                                         1 (2%)                                                          
      Capsule, Hematocyst                                                        1 (2%)                                             
   Thymus                                             (56)         (52)         (49)         (48)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Necrosis                                                                   4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (56)         (54)         (56)                                   
      Hyperplasia                                                   1 (2%)       2 (4%)       2 (4%)                                
   Skin                                               (57)         (58)         (57)         (58)                                   
      Congestion                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)         (58)         (57)         (58)                                   
      Fracture Healed                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (58)         (56)         (58)                                   
      Compression                                      1 (2%)       1 (2%)                    1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                  24 (41%)     10 (17%)     15 (27%)     25 (43%)                               
      Ventricle, Dilatation                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (58)         (57)         (57)                                   
      Congestion                                       2 (3%)                    1 (2%)                                             
      Embolus, Focal                                                1 (2%)                                                          
      Hemorrhage                                       3 (5%)       5 (9%)       6 (11%)      3 (5%)                                
      Inflammation, Chronic                                                      2 (4%)                                             
      Pigmentation, Hemosiderin                                     2 (3%)                    3 (5%)                                
      Pigmentation, Hemoglobin                                                   1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)                    2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       1 (2%)       2 (4%)       3 (5%)                                
      Interstitium, Infiltration Cellular, Mixed                                                                                    
          Cell                                                      3 (5%)       1 (2%)                                             
   Nose                                               (57)         (58)         (55)         (55)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative                                            1 (2%)                                
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (6)          (4)          (8)                                    
      Hyperplasia                                                   2 (33%)      3 (75%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (57)         (57)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Infarct, Chronic                                              2 (3%)       1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell          5 (9%)       3 (5%)       4 (7%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)       1 (2%)                                
      Nephropathy                                                   1 (2%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                    1 (2%)                                
      Polyarteritis                                                              1 (2%)                                             
      Glomerulus, Amyloid Deposition                                                          1 (2%)                                
      Pelvis, Infiltration Cellular, Mononuclear                                                                                    
          Cell                                                                   1 (2%)                                             
      Renal Tubule, Dilatation                         1 (2%)                                                                       
   Urinary Bladder                                    (55)         (53)         (53)         (46)                                   
      Hyperplasia, Lymphoid                            4 (7%)       2 (4%)       2 (4%)       1 (2%)                                
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Metaplasia, Squamous                                                       1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          58           58           58           58                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4           13           20           20                                     
    Moribund Sacrifice                                 6           24           26           27                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           11            2            1                                     

  Animals Examined Microscopically                    58           58           58           58                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (51)         (43)         (41)         (37)                                   
      Inflammation, Chronic Active                                                            1 (3%)                                
   Intestine Large, Colon                             (57)         (52)         (51)         (49)                                   
      Diverticulum                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (56)         (50)         (44)         (44)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)                                                          
   Intestine Small, Ileum                             (56)         (48)         (45)         (46)                                   
      Peyer's Patch, Inflammation, Chronic Active      1 (2%)                                                                       
   Liver                                              (58)         (58)         (58)         (58)                                   
      Angiectasis                                                   7 (12%)     15 (26%)     15 (26%)                               
      Basophilic Focus                                 1 (2%)       1 (2%)       5 (9%)       4 (7%)                                
      Clear Cell Focus                                 1 (2%)                    2 (3%)       1 (2%)                                
      Eosinophilic Focus                               1 (2%)       6 (10%)     10 (17%)      7 (12%)                               
      Fatty Change                                     6 (10%)      1 (2%)       1 (2%)       1 (2%)                                
      Granuloma                                                                               1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)       5 (9%)                                             
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Infarct                                          1 (2%)       6 (10%)      2 (3%)       5 (9%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       5 (9%)       4 (7%)       5 (9%)                                
      Mixed Cell Focus                                 3 (5%)       3 (5%)       6 (10%)      3 (5%)                                
      Necrosis, Coagulative, Multifocal                5 (9%)       4 (7%)      13 (22%)     12 (21%)                               
      Thrombosis                                                    1 (2%)       3 (5%)                                             
      Bile Duct, Hyperplasia                                        1 (2%)                                                          
      Centrilobular, Necrosis                                                    1 (2%)       1 (2%)                                
      Hepatocyte, Regeneration                                                                1 (2%)                                
   Mesentery                                          (2)          (3)          (2)          (7)                                    
      Angiectasis                                                                             1 (14%)                               
      Fat, Hemorrhage                                                                         2 (29%)                               
      Fat, Necrosis                                    1 (50%)      2 (67%)      1 (50%)      3 (43%)                               
   Pancreas                                           (58)         (58)         (56)         (55)                                   
      Granuloma                                        1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Ectasia                                                              1 (2%)                                             
   Salivary Glands                                    (58)         (58)         (58)         (58)                                   
      Infiltration Cellular, Mononuclear Cell         11 (19%)      9 (16%)      1 (2%)       6 (10%)                               
   Stomach, Forestomach                               (58)         (58)         (56)         (56)                                   
      Foreign Body                                     1 (2%)                                                                       
      Granuloma                                        1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Squamous                                                      1 (2%)                                             
      Inflammation, Focal                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                    1 (2%)                                
      Epithelium, Hyperplasia                          2 (3%)       3 (5%)       2 (4%)       4 (7%)                                
      Serosa, Inflammation                             1 (2%)                                                                       
   Stomach, Glandular                                 (58)         (58)         (56)         (55)                                   
      Foreign Body                                                                            1 (2%)                                
      Necrosis                                                                                2 (4%)                                
   Tooth                                              (2)          (2)          (4)          (8)                                    
      Dysplasia                                        1 (50%)      1 (50%)                   3 (38%)                               
      Inflammation, Suppurative                        1 (50%)                   4 (100%)     5 (63%)                               
      Peridontal Tissue, Proliferation Connective                                                                                   
          Tissue                                                    1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (58)         (58)         (58)                                   
      Cardiomyopathy                                   2 (3%)                    2 (3%)                                             
      Fibrosis                                                                                1 (2%)                                
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (58)         (57)         (58)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      1 (2%)       3 (5%)                                                          
      Capsule, Hyperplasia                            35 (60%)     30 (52%)     31 (54%)     22 (38%)                               
   Islets, Pancreatic                                 (58)         (58)         (56)         (55)                                   
      Hyperplasia                                      2 (3%)       1 (2%)       8 (14%)      3 (5%)                                
   Pituitary Gland                                    (57)         (53)         (53)         (54)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
      Pars Intermedia, Hemorrhage                                   1 (2%)                                                          
   Thyroid Gland                                      (58)         (58)         (57)         (57)                                   
      Ultimobranchial Cyst                                          1 (2%)       2 (4%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (2)                                                 
      Infiltration Cellular, Mononuclear Cell                                    1 (50%)                                            
      Necrosis                                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (58)         (58)         (58)                                   
      Granuloma Sperm                                                                         1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
   Preputial Gland                                    (58)         (58)         (56)         (58)                                   
      Atrophy                                                                    1 (2%)                                             
      Ectasia                                          2 (3%)       6 (10%)      2 (4%)       1 (2%)                                
      Infiltration Cellular, Mononuclear Cell          7 (12%)      7 (12%)      8 (14%)      3 (5%)                                
      Inflammation, Chronic                            5 (9%)       5 (9%)       4 (7%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       4 (7%)      10 (18%)      3 (5%)                                
   Prostate                                           (56)         (54)         (54)         (53)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
   Seminal Vesicle                                    (58)         (57)         (57)         (54)                                   
      Dilatation                                       4 (7%)       1 (2%)       2 (4%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                    2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
   Testes                                             (58)         (58)         (58)         (58)                                   
      Atrophy, Focal                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (58)         (57)         (57)                                   
      Hyperplasia, Neutrophil                          2 (3%)       1 (2%)       3 (5%)       2 (4%)                                
   Lymph Node                                         (3)          (1)          (2)                                                 
      Iliac, Hemorrhage                                                          1 (50%)                                            
      Iliac, Hyperplasia, Lymphoid                     1 (33%)                                                                      
      Iliac, Hyperplasia, Plasma Cell                                            2 (100%)                                           
      Iliac, Pigmentation, Hemosiderin                                           1 (50%)                                            
      Renal, Hyperplasia, Lymphoid                     1 (33%)                                                                      
   Lymph Node, Bronchial                              (42)         (42)         (43)         (33)                                   
      Hemorrhage                                                    2 (5%)                                                          
      Hyperplasia, Lymphoid                                         2 (5%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Lymph Node, Mandibular                             (44)         (37)         (38)         (42)                                   
      Congestion                                                    1 (3%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Histiocytic                                      1 (3%)       2 (5%)                                             
      Hyperplasia, Lymphoid                                         1 (3%)       1 (3%)                                             
      Hyperplasia, Plasma Cell                                                                1 (2%)                                
      Pigmentation, Hemosiderin                                     2 (5%)       1 (3%)                                             
   Lymph Node, Mesenteric                             (57)         (52)         (51)         (50)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)       2 (4%)       2 (4%)                                             
      Hyperplasia, Histiocytic                         2 (4%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mediastinal                            (37)         (39)         (40)         (36)                                   
      Congestion                                                    1 (3%)                                                          
      Hematopoietic Cell Proliferation                                           1 (3%)                                             
      Hemorrhage                                                                 3 (8%)       2 (6%)                                
      Hyperplasia, Histiocytic                                                   1 (3%)       2 (6%)                                
      Hyperplasia, Lymphoid                            1 (3%)                    1 (3%)                                             
   Spleen                                             (58)         (58)         (56)         (56)                                   
      Atrophy                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                16 (28%)     36 (62%)     46 (82%)     45 (80%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Pigmentation, Melanin                                         2 (3%)                                                          
   Thymus                                             (51)         (49)         (44)         (46)                                   
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (58)         (57)         (58)         (58)                                   
      Acanthosis                                       1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Inflammation, Chronic                            2 (3%)       5 (9%)       2 (3%)       3 (5%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Ulcer                                            2 (3%)       4 (7%)                    5 (9%)                                
      Prepuce, Acanthosis                              1 (2%)       2 (4%)                                                          
      Prepuce, Inflammation, Chronic                                2 (4%)                                                          
      Prepuce, Inflammation, Suppurative                                                      1 (2%)                                
      Prepuce, Pigmentation, Melanin                                1 (2%)                                                          
      Prepuce, Ulcer                                                1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Congestion                                                         1 (2%)                                
      Subcutaneous Tissue, Hemorrhage                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)         (58)         (58)         (58)                                   
      Fracture                                                                                1 (2%)                                
      Sternum, Developmental Malformation                                                     2 (3%)                                
      Sternum, Fracture Healed                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (58)         (58)         (58)                                   
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Mineralization                                  28 (48%)     19 (33%)     15 (26%)     30 (52%)                               
      Necrosis, Liquifactive                           2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (57)         (58)         (56)         (56)                                   
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Exudate, Mucopurulent                                                      2 (4%)       2 (4%)                                
      Hemorrhage                                                                              1 (2%)                                
      Metaplasia, Squamous                                                                    2 (4%)                                
   Lung                                               (58)         (58)         (58)         (58)                                   
      Congestion                                                    2 (3%)       5 (9%)       1 (2%)                                
      Crystals                                                      1 (2%)                                                          
      Hemorrhage                                       6 (10%)      4 (7%)       2 (3%)       1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)       1 (2%)                                
      Alveolus, Hemorrhage, Multifocal                 1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte      4 (7%)       5 (9%)       1 (2%)       1 (2%)                                
      Interstitium, Infiltration Cellular, Mixed                                                                                    
          Cell                                         1 (2%)                                                                       
   Nose                                               (58)         (57)         (56)         (57)                                   
      Inflammation, Suppurative                        1 (2%)                    3 (5%)       1 (2%)                                
      Proliferation Connective Tissue, Multifocal                   1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative                                            1 (2%)                                
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration                                   1 (2%)                                                                       
      Respiratory Epithelium, Degeneration                                                    1 (2%)                                
      Vomeronasal Organ, Hypertrophy                                             1 (2%)                                             
   Trachea                                            (57)         (57)         (56)         (56)                                   
      Cytoplasmic Alteration                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05132-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (2)                                                 
      Degeneration, Diffuse                                                      1 (50%)                                            
      Phthisis Bulbi                                                             1 (50%)                                            
      Retinal Detachment                                                         1 (50%)                                            
      Cornea, Inflammation, Chronic                                              1 (50%)                                            
   Harderian Gland                                    (7)          (10)         (5)          (7)                                    
      Hyperplasia                                                                1 (20%)      1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (58)         (58)                                   
      Cyst                                             2 (3%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell          3 (5%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    2 (3%)                                             
      Inflammation, Suppurative                        2 (3%)                                                                       
      Nephropathy                                     35 (60%)     15 (26%)     10 (17%)     19 (33%)                               
      Bilateral, Pelvis, Dilatation                                 1 (2%)       1 (2%)                                             
      Renal Tubule, Dilatation                                      4 (7%)      22 (38%)     46 (79%)                               
      Renal Tubule, Karyomegaly                        1 (2%)       2 (3%)      14 (24%)     38 (66%)                               
   Urinary Bladder                                    (58)         (53)         (53)         (52)                                   
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (3%)                    2 (4%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------