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TDMS Study 05132-06 Pathology Tables

NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12

                                                          Core Animals




       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  I  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X     X                                            X            |             
      Hepatocellular Adenoma               |       X        X        X  X     X  X        X     X                     |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +  +                          +                       +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Capsule, Adenoma                     |       X                                                                  |             
      Capsule, Carcinoma                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                                                                          |             
      Pars Distalis, Adenoma               |                                                 X                        |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cystadenoma                          |       X                                                                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Luteoma                              | X                                                              X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                                                          |             
      Cervix, Granular Cell Tumor NOS      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +                  |             
      Axillary, Histiocytic Sarcoma        |                                                                          |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                       X                  |             
      Lumbar, Lymphoma Malignant Mixed     |                                                       X                  |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  M  M  +  M  M  M  +  +  +  +  +  +  +  M  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                                            X     X                     |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                      X   |             
      Carcinoma, Metastatic, Mammary Gland |                                                 X                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |          X                                                               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X           X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hepatocellular Carcinoma             |                               X                                          |          4 |
      Hepatocellular Adenoma               |             X           X     X     X                 X     X            |         14 |
      Hepatocellular Adenoma, Multiple     |                            X                                             |          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +     +           +           +            |   9        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Capsule, Adenoma                     |                                                                          |          1 |
      Capsule, Carcinoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Adenoma                              |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  M  M  M  +  M  M  M  M  +  M  M  +  +  +  +  M  M  +  +      |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |             X                             X           X                  |          4 |
      Pars Intermedia, Adenoma             |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Follicular Cell, Adenoma             |    X                       X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +      |  42        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cystadenoma                          |       X                                                                  |          2 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Luteoma                              |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Polyp Stromal                        |                                                       X                  |          1 |
      Cervix, Granular Cell Tumor NOS      |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +           +           +                 +      |   5        |
      Axillary, Histiocytic Sarcoma        |                                                 X                        |          1 |
      Iliac, Histiocytic Sarcoma           |                                                 X                        |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                         X                                                |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +      |  40        |
      Lymphoma Malignant Mixed             |                         X                                         X      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +      |  39        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                         X                                         X      |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  M  +  M  M  +  M  M  +  +  I  M  M  +  M  +  M  +  +  +      |  28        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                         X                                         X      |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  46        |
      Lymphoma Malignant Mixed             |                                                             X     X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Osteosarcoma                         |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Astrocytoma NOS                      |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |                                        X              X                  |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                         X                                         X      |          2 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                          +                                    |   3        |
      Adenoma                              |          X                                                               |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant Mixed             |                         X                                   X     X      |          5 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  A  A  +  +  +  +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  I  +  A|             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |       X                 X  X                                             |             
      Hemangioma, Multiple                 | X                                                                        |             
      Hemangiosarcoma                      |    X              X        X  X     X  X              X  X  X  X     X   |             
      Hemangiosarcoma, Multiple            |          X                                   X                           |             
      Hepatocellular Carcinoma             |    X  X                 X     X     X  X     X  X        X  X  X  X  X   |             
      Hepatocellular Carcinoma, Multiple   |             X        X                                                   |             
      Hepatocellular Adenoma               |    X        X                 X     X  X                                 |             
      Hepatocellular Adenoma, Multiple     | X        X        X     X  X                                             |             
      Histiocytic Sarcoma                  |                            X     X     X  X        X  X  X  X     X  X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +  +  +  +              +                                 |             
      Hemangiosarcoma                      |          X                                                               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X                       X      |             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
      Squamous Cell Papilloma              |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  +  M  M  M  M  +  +  +  M  +  M  +  +  M  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Sarcoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                  X        X        X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X        X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  I  +  +  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  M  +  M  +  M|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                           X        X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  M  M  M  +  +|             
      Histiocytic Sarcoma                  |                                  X        X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  I  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Histiocytic Sarcoma                  |                                  X        X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  M  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X        X        X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X        X           X           X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Leiomyosarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                X                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |       X                                                                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X     X                                X  X        X           X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                  X        X        X  X     X     X  X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +     +                                         +     +   |             
      Adenoma                              |                                                                X     X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X           X           X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leiomyosarcoma, Metastatic, Uterus   |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X     X     X  X        X  X  X  X     X  X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |     L      |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  M  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +      |  42        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +      |  39        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +      |  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +      |  39        |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemangioma                           |                                        X                                 |          4 |
      Hemangioma, Multiple                 |                                                                          |          1 |
      Hemangiosarcoma                      |    X                 X     X     X              X     X  X     X         |         19 |
      Hemangiosarcoma, Multiple            | X     X        X                    X                       X     X      |          8 |
      Hepatocellular Carcinoma             |    X  X        X  X        X     X  X  X     X  X                        |         23 |
      Hepatocellular Carcinoma, Multiple   |                      X        X                       X                  |          5 |
      Hepatocellular Adenoma               | X     X                       X  X              X                        |         10 |
      Hepatocellular Adenoma, Multiple     |    X                       X                                             |          7 |
      Histiocytic Sarcoma                  |       X  X  X     X           X           X  X     X  X  X        X      |         21 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +        +  +  +                 +        +         |  13        |
      Hemangiosarcoma                      |                                  X                                       |          2 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |     L      |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Adenoma                              |                                                 X                        |          1 |
      Histiocytic Sarcoma                  |                   X                                   X                  |          3 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +      |  45        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  M  +  +  +  M  M  M  M  +  +  +  +  M  M  +  +  +  +      |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +      |  45        |
      Pars Distalis, Adenoma               | X                          X                                X  X         |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Follicular Cell, Adenoma             |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +      |  42        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemangiosarcoma                      |    X                                                                     |          1 |
      Histiocytic Sarcoma                  |             X                                         X                  |          5 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |     L      |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |          X  X                                         X                  |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +              +                             +     +     +      |   6        |
      Iliac, Histiocytic Sarcoma           |                                                       X                  |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                         X                                                |          1 |
      Renal, Histiocytic Sarcoma           |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +      |  36        |
      Histiocytic Sarcoma                  |          X                                         X                     |          4 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +      |  35        |
      Histiocytic Sarcoma                  |          X                                                               |          3 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +      |  40        |
      Histiocytic Sarcoma                  |       X  X                                               X               |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  +  +  +  +  I  +  I  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +      |  35        |
      Histiocytic Sarcoma                  |          X  X                                X        X  X        X      |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |          X  X                                         X                  |          7 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  42        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Rib, Leiomyosarcoma, Metastatic,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |     L      |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X                             X                                       |          8 |
      Histiocytic Sarcoma                  |       X  X  X                 X              X     X  X  X        X      |         16 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   6        |
      Adenoma                              |                                        X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                              X     X  X           X      |          7 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                   X           X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Leiomyosarcoma, Metastatic, Uterus   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Sarcoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |       X  X  X     X           X           X  X     X  X  X        X      |         21 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |     L      |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                   X           X                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  A  +  +  +  +  +  M  +  M  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangioma, Multiple                 |    X                                                                     |             
      Hemangiosarcoma                      |    X  X           X  X              X           X     X     X            |             
      Hemangiosarcoma, Multiple            | X                                                        X              X|             
      Hepatocellular Carcinoma             | X     X        X        X                 X     X  X  X  X              X|             
      Hepatocellular Carcinoma, Multiple   |                               X  X                                       |             
      Hepatocellular Adenoma               | X  X  X     X                 X                                         X|             
      Hepatocellular Adenoma, Multiple     |                         X                 X     X                        |             
      Histiocytic Sarcoma                  |    X     X     X  X  X  X           X  X           X     X     X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                  +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  M  M  M  +  M  M  M  M  +  +     +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  M  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
      Follicular Cell, Adenoma             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  M  +  +  +  +  +  M  M  +  +  +  M  +     M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                               X   |             
      Periovarian Tissue, Histiocytic      |                                                                          |             
          Sarcoma                          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
      Histiocytic Sarcoma                  |                      X                             X                 X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                    +                                                   |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                      X                                                   |             
      Renal, Histiocytic Sarcoma           |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                                                                X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  I  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  M  +  +|             
      Histiocytic Sarcoma                  |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  M  A  +  +|             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                   X  X                 X           X                 X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  M  +  +  M  +  +  +  +  M  +     +  +  +  M  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                   X  X              X              X           X     X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A  +  +|             
      Histiocytic Sarcoma                  |                   X                 X              X                 X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  +  M  +  M  +|             
      Histiocytic Sarcoma                  |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |          X                                                     X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                X                                                         |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X        X        X                                       |             
      Histiocytic Sarcoma                  |    X     X        X  X  X                          X           X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +     +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                             X                 X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  A  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |    X     X     X  X  X  X           X  X           X     X     X  X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |     A      |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  M  +  A  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  A      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  A      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemangioma                           |                                        X                                 |          1 |
      Hemangioma, Multiple                 |                                                                          |          1 |
      Hemangiosarcoma                      | X        X        X  X  X                          X  X                  |         15 |
      Hemangiosarcoma, Multiple            |       X        X           X  X     X           X        X  X     X      |         12 |
      Hepatocellular Carcinoma             |    X           X        X                       X        X               |         15 |
      Hepatocellular Carcinoma, Multiple   | X           X              X        X  X                                 |          7 |
      Hepatocellular Adenoma               |       X              X                                   X  X     X      |         11 |
      Hepatocellular Adenoma, Multiple     | X                       X  X           X        X  X                     |          9 |
      Histiocytic Sarcoma                  |    X     X                       X  X     X  X                           |         19 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +           +                    +           +               |   7        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  44        |
      Histiocytic Sarcoma                  |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Squamous Cell Papilloma              |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  M  M      |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Pars Distalis, Adenoma               |                      X              X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  21                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |     A      |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +      |  38        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Histiocytic Sarcoma                  |                                  X        X                              |          4 |
      Periovarian Tissue, Histiocytic      |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Histiocytic Sarcoma                  |                                  X           X                           |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                   +                              |   4        |
      Iliac, Histiocytic Sarcoma           |                                           X                              |          1 |
      Pancreatic, Histiocytic Sarcoma      |                                                                          |          1 |
      Renal, Histiocytic Sarcoma           |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  A  +  +  +  +  M      |  40        |
      Histiocytic Sarcoma                  |                                  X  X     X  X                           |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  +  +  +  +  +  I  M  +  M  +  M  +  M  +  +  +      |  34        |
      Histiocytic Sarcoma                  |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +      |  41        |
      Hemangioma                           |                            X                                             |          1 |
      Histiocytic Sarcoma                  |          X                                X                              |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +      |  35        |
      Histiocytic Sarcoma                  |    X                             X        X                              |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Histiocytic Sarcoma                  |    X                             X        X  X                           |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  I  +  +  +  +  +  +  +      |  39        |
      Histiocytic Sarcoma                  |                                  X                                       |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemangioma                           |                                                             X            |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  22                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |     A      |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  43        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Alveolar/Bronchiolar Adenoma         | X                       X                                                |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |             X                          X                 X               |          6 |
      Histiocytic Sarcoma                  |    X                             X  X     X  X                           |         13 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +           +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                                  X                                       |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |    X     X                       X  X     X  X                           |         19 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|             
                             DAY ON TEST   | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|             
                                           | 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  I  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  A  +  +  A  +  +  +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                   X        X     X     X  X  X     X              X  X   |             
      Hemangiosarcoma, Multiple            |       X     X  X     X        X                       X  X  X            |             
      Hepatocellular Carcinoma             |    X        X     X  X  X        X                                       |             
      Hepatocellular Carcinoma, Multiple   |                                              X                    X      |             
      Hepatocellular Adenoma               |             X           X                             X              X   |             
      Hepatocellular Adenoma, Multiple     |    X                 X                 X                                 |             
      Histiocytic Sarcoma                  |          X        X        X  X           X  X  X        X  X  X     X   |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +              +                             +         |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                        X                                 |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  A  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X                                      X              X     X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|             
                             DAY ON TEST   | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|             
                                           | 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma                  |                                                 X        X     X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                               X                          X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +           +            |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                                                             X            |             
      Renal, Histiocytic Sarcoma           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                            X  X                          X     X         |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  M  A  M  M  +  +  +  M  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                    X        X     X         |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  +  M  M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  M  +|             
      Histiocytic Sarcoma                  |                               X                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                    X           X  X  X        X     X         |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                                                 X              X         |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  25                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|             
                             DAY ON TEST   | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|             
                                           | 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hemangiosarcoma, Metastatic, Liver   |                                           X                              |             
      Hemangiosarcoma, Metastatic, Pancreas|                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X                 X                                                   |             
      Histiocytic Sarcoma                  |          X                 X  X           X  X  X        X  X  X         |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                       +           +   |             
      Adenoma                              |                                  X                       X           X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                               X                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  A  +  I  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X        X        X  X           X  X  X        X  X  X     X   |             
      Lymphoma Malignant Mixed             |                                  X                                      X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |     L      |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  A  M  M  +  A  A  +  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +      |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  +  A  +  A  A  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  A  A  +  +  A  A  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  A  A  +  +  A  A  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  A  +  +  A  A  +  +      |  35        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemangioma                           |                         X                                                |          1 |
      Hemangiosarcoma                      |       X        X     X     X              X     X     X  X     X  X      |         19 |
      Hemangiosarcoma, Multiple            |    X     X  X     X           X                    X        X            |         15 |
      Hepatocellular Carcinoma             |                         X  X     X        X  X     X           X         |         13 |
      Hepatocellular Carcinoma, Multiple   | X           X                       X                       X     X      |          7 |
      Hepatocellular Adenoma               |                   X           X                 X     X                  |          8 |
      Hepatocellular Adenoma, Multiple     |                X        X  X                       X                     |          7 |
      Histiocytic Sarcoma                  |                X  X        X        X     X     X              X         |         18 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                                                               |   6        |
      Sarcoma                              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                    +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  +  +  M  +  M  +  +  M  M  M  M  M  +  +  M      |  31        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  27                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |     L      |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |  46        |
      Pars Distalis, Adenoma               |                                                       X                  |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Follicular Cell, Adenoma             |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +      |  46        |
      Cystadenoma                          |                                                 X                 X      |          2 |
      Histiocytic Sarcoma                  |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                          +     +        +               |   6        |
      Iliac, Histiocytic Sarcoma           |                                                 X                        |          1 |
      Pancreatic, Histiocytic Sarcoma      |                                                                          |          1 |
      Renal, Histiocytic Sarcoma           |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +      |  38        |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  M  M  M      |  32        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +      |  43        |
      Histiocytic Sarcoma                  |                            X                    X                        |          6 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +      |  33        |
      Histiocytic Sarcoma                  |                                           X     X                        |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                            X              X                              |          9 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M      |  38        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  28                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |     L      |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
      Subcutaneous Tissue, Sarcoma         | X                                      X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Alveolar/Bronchiolar Adenoma         |          X                                            X     X            |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                              X                           |          1 |
      Hemangiosarcoma, Metastatic, Liver   |    X        X                                                            |          3 |
      Hemangiosarcoma, Metastatic, Pancreas|                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                  X                                X      |          4 |
      Histiocytic Sarcoma                  |                   X                       X     X              X         |         13 |
      Sarcoma, Metastatic, Skin            |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                    +                                      +         |   6        |
      Adenoma                              |    X                    X                                      X         |          6 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  M  +  M  I      |  37        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  29                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |     L      |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                X  X        X        X     X     X              X         |         18 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  30                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  M  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                  X        X     X                        |             
      Hepatocellular Carcinoma, Multiple   |                            X                                         X   |             
      Hepatocellular Adenoma               |             X                             X        X                     |             
      Hepatocellular Adenoma, Multiple     | X                    X                       X           X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  +  M  M  +  +  +  M  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          A                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +     +                  |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                 X                        |             
      Iliac, Lymphoma Malignant Mixed      |                                                 X     X                  |             
      Lumbar, Lymphoma Malignant Mixed     |                                                       X                  |             
      Renal, Lymphoma Malignant Mixed      |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  M  M|             
      Lymphoma Malignant Mixed             |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  M  M  M  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +|             
      Lymphoma Malignant Mixed             |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X     X                       X     X                          X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                               X           X                              |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Gland                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       M     +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +  +                                               +         |             
      Adenoma                              |             X  X                                                         |             
      Carcinoma                            |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X     X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |     L      |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hepatocellular Carcinoma             |             X           X  X           X                                 |          7 |
      Hepatocellular Carcinoma, Multiple   |                X                                            X            |          4 |
      Hepatocellular Adenoma               | X        X           X           X  X     X  X        X                  |         11 |
      Hepatocellular Adenoma, Multiple     |                               X        X                                 |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Squamous Cell Papilloma              |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  M  +  +  +  M  M  M  M  +  +  +  +  M  +  +      |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |     L      |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                              +                           |   3        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          2 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +      |  36        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +      |  36        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  +  M  +  +  +  +  M  M  M  M  +  +  +  M  +  +  +  +  M      |  30        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemangiosarcoma                      |                                     X                                    |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  43        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M      |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  35                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     A      |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |     L      |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         |                         X        X        X                    X         |          9 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |       X                                                                  |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +  +                    +         |   6        |
      Adenoma                              |                                        X  X                    X         |          5 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  36                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  A  A  A  +  +  +  A  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Hemangioma                           |                                  X                                       |             
      Hemangioma, Multiple                 |    X                       X  X                                X  X     X|             
      Hemangiosarcoma                      |                      X     X                                      X      |             
      Hemangiosarcoma, Multiple            |    X     X  X                          X        X     X  X  X  X         |             
      Hepatocellular Carcinoma             | X     X     X        X  X                                      X         |             
      Hepatocellular Carcinoma, Multiple   |                                           X              X               |             
      Hepatocellular Adenoma               |          X           X     X              X              X           X  X|             
      Hepatocellular Adenoma, Multiple     |                               X                    X                     |             
      Histiocytic Sarcoma                  | X              X              X  X                       X  X  X         |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                       +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Lymphoma Malignant Mixed    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  M  +  M  +  M  M  M  +  +  M  +  +  M  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                   X      |             
      Follicular Cell, Carcinoma           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
      Renal, Histiocytic Sarcoma           | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  I  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X              X                 X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +|             
      Histiocytic Sarcoma                  | X                                X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Histiocytic Sarcoma                  | X              X                 X                       X               |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  M|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Histiocytic Sarcoma                  | X                                X                                       |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                X                                       |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                    X     X        X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |             
      Carcinoma                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
      Histiocytic Sarcoma                  | X              X              X                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                       +           +         |             
      Adenoma                              |                                                    X           X         |             
      Carcinoma                            |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X              X                                         X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X              X              X  X                       X  X  X         |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |     L      |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  M  +  +  +  M  +  +  A  A  +  +  +  A  +  A  +  +  +  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +      |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Lung          |                   X                                                      |          1 |
      Hemangioma                           |    X                                                              X      |          3 |
      Hemangioma, Multiple                 |                                                          X               |          7 |
      Hemangiosarcoma                      |                   X                                      X               |          5 |
      Hemangiosarcoma, Multiple            | X           X              X        X  X        X  X                     |         16 |
      Hepatocellular Carcinoma             |          X           X  X                    X                    X      |         11 |
      Hepatocellular Carcinoma, Multiple   |    X           X                 X     X              X  X     X         |          9 |
      Hepatocellular Adenoma               |             X     X                       X     X                        |         11 |
      Hepatocellular Adenoma, Multiple     | X                          X        X              X                     |          6 |
      Histiocytic Sarcoma                  | X           X              X     X        X                              |         12 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                 +                                    |   3        |
      Carcinoma, Metastatic, Lung          |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Lung          |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Capsule, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  M  +  M      |  28        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  40                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |     L      |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M      |  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Follicular Cell, Adenoma             | X                                      X                                 |          3 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                      +               |   2        |
      Carcinoma, Metastatic, Lung          |                   X                                                      |          1 |
      Hemangioma                           |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leiomyosarcoma                       |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  M  +  +  +      |  36        |
      Histiocytic Sarcoma                  |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  M  I  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +      |  34        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  I  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M      |  42        |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  M  +  +  M  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +      |  34        |
      Carcinoma, Metastatic, Lung          |                   X                                                      |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  M  +  +  +  +      |  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  41                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |     A      |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |     L      |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M      |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Subcutaneous Tissue, Hemangioma      |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         |                                        X     X  X                        |          7 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         | X                                                                        |          1 |
      Alveolar/Bronchiolar Carcinoma       |                X                                      X  X               |          4 |
      Carcinoma                            |                   X                                                      |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |          X           X  X                             X        X  X      |          7 |
      Histiocytic Sarcoma                  | X                                X        X                              |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                          +           +           +        +            |   8        |
      Adenoma                              | X                          X           X           X        X            |          7 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +      |  43        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  | X           X              X     X        X                              |         12 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  42                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  A  +  M  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  M  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                           X  X                           |             
      Hemangioma, Multiple                 |                            X                                             |             
      Hemangiosarcoma                      |       X        X                    X                       X            |             
      Hemangiosarcoma, Multiple            | X        X  X        X        X  X           X  X                    X   |             
      Hepatocellular Carcinoma             |    X     X     X  X     X  X        X  X              X     X  X  X     X|             
      Hepatocellular Carcinoma, Multiple   | X           X                             X        X                 X   |             
      Hepatocellular Adenoma               |                X              X     X                                    |             
      Hepatocellular Adenoma, Multiple     |    X              X              X                       X               |             
      Histiocytic Sarcoma                  |       X                                               X           X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +              +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  M  +  +  M  M  +  +  +  +  M  M  +  M  M  I  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |             X                                                            |             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                             +                                    |             
      Renal, Histiocytic Sarcoma           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  I  M  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  M  +  M  M  M  +  +  +  M  +  M  +  +  +  +  +  M  +  I|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                                  X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma       |                      X                                               X   |             
      Hemangiosarcoma, Metastatic, Liver   |             X                       X                                    |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |             X  X        X           X     X        X  X     X  X     X   |             
      Histiocytic Sarcoma                  |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                          +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +     +                    +     +|             
      Adenoma                              |                                        X     X                    X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Liver   |             X                                                            |             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |       X                                               X           X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |     L      |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  M  +  +  +  +  +  +  +  +  A  M  A  A  +  A  +  +  +  A  +  A  +      |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  A  A  A  +  +  +  +  +  +  +  +  +      |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  I  +      |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  A  A  A  A  +  A  +  +  +  +  +  A  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +  +  +  A  +  A  A  +  A  +  +  +  A  +  A  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  A  +  +  +  +  +  +  +  A  A  A  A  +  A  +  +  +  +  +  A  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +  +  +  A  A  A  A  +  A  +  +  +  +  +  A  +      |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemangioma                           |                                  X                                       |          3 |
      Hemangioma, Multiple                 |             X                                                            |          2 |
      Hemangiosarcoma                      |             X                 X           X                 X  X  X      |         10 |
      Hemangiosarcoma, Multiple            |    X     X           X  X  X           X     X     X                     |         17 |
      Hepatocellular Carcinoma             |       X  X        X     X           X  X     X  X  X     X     X         |         24 |
      Hepatocellular Carcinoma, Multiple   | X                    X           X                                X      |          9 |
      Hepatocellular Adenoma               |             X        X                                                   |          5 |
      Hepatocellular Adenoma, Multiple     |                            X              X  X                           |          7 |
      Histiocytic Sarcoma                  |                X                                      X     X     X      |          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                     +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  I  +  M  +      |  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +      |  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  46                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |     L      |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  M  +  +  +  +  +  +  +  A  M  A  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  +  +  +  +  +  A  +  +  +  M  +  I  +  +  M  +      |  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  M  +  M  +  +  I  +  I      |  32        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  M  +  +  +  +      |  41        |
      Histiocytic Sarcoma                  |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  I  +  +  +  +  +  +  +  +  +  A  M  +  M  +  +  M  +  +  +  M      |  32        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  +  +  A  M  +  M  M  +  +  M  +  +  +      |  34        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |     A      |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |     L      |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         |          X           X     X  X  X           X           X     X  X      |         12 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |          3 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                   X                    X           X           X         |         14 |
      Histiocytic Sarcoma                  |                                                       X     X            |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                             +            |   5        |
      Adenoma                              |                                                             X            |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
      Histiocytic Sarcoma                  |                X                                            X            |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +      |  43        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                X                                      X     X     X      |          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  A  +  +  M  +  +  +  +  +  +  M  A  M  A  +  A  M  M  A  M  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  A  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  A  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  A  A  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  A  A  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hemangioma                           |                                                                          |             
      Hemangioma, Multiple                 |                                     X                                    |             
      Hemangiosarcoma                      |       X  X  X        X     X  X        X  X     X           X  X     X   |             
      Hemangiosarcoma, Multiple            | X              X        X        X                    X  X        X      |             
      Hepatocellular Carcinoma             |    X                       X     X  X  X        X     X  X  X  X  X  X  X|             
      Hepatocellular Carcinoma, Multiple   |                   X  X                             X                     |             
      Hepatocellular Adenoma               |                            X           X  X           X                 X|             
      Hepatocellular Adenoma, Multiple     |             X                    X                             X  X      |             
      Histiocytic Sarcoma                  | X                                   X     X                              |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +        +                                       |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +                                                     +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  M  M  M  +  +  M  +  +  +  +  +  M  I  +  +  M  M  +  I  M  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  +  M  M  +  +  +  M  M  M  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  M  M  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  M  +  M  +  I  M  +  M  +  +  M  M  +  +  M  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  M|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Carcinoma, Metastatic, Lung          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                 X                              |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Carcinoma                            |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hemangiosarcoma, Metastatic, Liver   | X                                                              X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                   X  X                                X        X         |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                       +                                          |             
      Adenoma                              |       X                       X                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                   X     X                              |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |     L      |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  +  A  +  +  A  M  +  +      |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  A  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  A  A  +  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  A  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                     X                                    |          1 |
      Hemangioma                           | X                                                                        |          1 |
      Hemangioma, Multiple                 |                                                                          |          1 |
      Hemangiosarcoma                      |       X     X                    X  X  X              X     X            |         19 |
      Hemangiosarcoma, Multiple            | X  X              X  X     X              X  X  X  X           X  X      |         18 |
      Hepatocellular Carcinoma             | X  X     X              X        X  X                          X         |         20 |
      Hepatocellular Carcinoma, Multiple   |       X           X           X                                          |          6 |
      Hepatocellular Adenoma               |             X     X           X     X  X     X     X           X         |         13 |
      Hepatocellular Adenoma, Multiple     |                      X                    X           X                  |          7 |
      Histiocytic Sarcoma                  |                X           X     X                                X      |          7 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                 +                                +            |   7        |
      Hemangioma                           |    X                                                                     |          1 |
      Hemangiosarcoma                      |                                                             X            |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Squamous Cell Carcinoma              |             X                                                            |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +                                            +        +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Lung          |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  52                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |     L      |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Adenoma                              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Leiomyoma                            |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Histiocytic Sarcoma                  |                X                 X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  I  M  +  +  A  +  +  +  +  M  +  M  +  M  +  +  M      |  26        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +      |  34        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  A  M  +  +  +  +  +  +  +  +  +  +  +      |  40        |
      Histiocytic Sarcoma                  |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  M  M  I  M  +  +  M      |  29        |
      Carcinoma, Metastatic, Lung          |                                                                X         |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Histiocytic Sarcoma                  |                X                 X                                       |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  M  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +      |  37        |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  53                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |     L      |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
      Carcinoma, Metastatic, Lung          |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |          3 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                           X                              |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma                            |                                                                X         |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                     X                                    |          1 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X  X  X                    X                                          |          8 |
      Histiocytic Sarcoma                  |                                  X                                X      |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                +         |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  54                                                               
NTP Experiment-Test: 05132-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:11:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |     A      |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |     L      |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +                          +     +                                    |   6        |
      Adenoma                              |    X                          X                                          |          4 |
      Carcinoma                            |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Carcinoma, Metastatic, Lung          |                                                                X         |          1 |
      Histiocytic Sarcoma                  |                X                 X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Histiocytic Sarcoma                  |                X           X     X                                X      |          7 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  55                                                               
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