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TDMS Study 05132-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 06                                                                                     TIME: 01:31:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 116-14-3        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 06                                                                                     TIME: 01:31:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 116-14-3        




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 06                                                                                     TIME: 01:31:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 116-14-3        




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF TETRAFLUOROETHYLENE

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hemangioma
                                            Hemangiosarcoma
                                            Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Stomach, Forestomach          Squamous Cell Carcinoma or Papilloma Squamous
              Thyroid Gland: Follicular Cell
                                            Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Hemangioma
                                            Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Histiocytic Sarcoma
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 06                                                                                     TIME: 01:31:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 116-14-3        




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF TETRAFLUOROETHYLENE

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hemangioma
                                            Hemangiosarcoma
                                            Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Skin                          Sarcoma
              All Organs                    Hemangioma
                                            Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Histiocytic Sarcoma
                                            Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
                                             Cell Type
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/58 (10%)   9/58 (16%)   4/58 (7%)    5/58 (9%)  |  3/58 (5%)    3/58 (5%)    0/57 (0%)    8/58 (14%) |
|ADJUSTED (b)           |  14.1%        37.7%        13.4%        26.1%      |   7.2%        39.7%         0.0%        63.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   0/10 (0%)    1/10 (10%) |  1/10 (10%)   0/10 (0%)    0/10 (0%)    2/10 (20%) |
|TERMINAL (d)           |  4/38 (11%)   2/11 (18%)   0/2 (0%)     0/1 (0%)   |  2/36 (6%)    1/4 (25%)    0/6 (0%)     2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      447          456 (I)   |   457 (I)      639          ---          457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.092      P=0.020 *    P=0.220      P=0.086    |  P<0.001 **   P=0.090      P=0.341N     P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.264N     P=0.294      P=0.352N     P=0.594N   |  P=0.004 **   P=0.483      P=0.341N     P=0.028 *  |
|LOGISTIC REGRESSION    |  P=0.326N     P=0.228      P=0.418N     P=0.520N   |  P=0.017 *    P=0.556      P=0.125N     P=0.086    |
|COCHRAN-ARMITAGE       |  P=0.280N                                          |  P=0.038 *                                         |
|FISHER EXACT           |               P=0.291      P=0.371N     P=0.500N   |               P=0.660N     P=0.125N     P=0.102    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/58 (12%)  10/58 (17%)   4/58 (7%)    6/58 (10%) |  3/58 (5%)    3/58 (5%)    0/57 (0%)    8/58 (14%) |
|ADJUSTED (b)           |  16.1%        44.6%        13.4%        28.0%      |   7.2%        39.7%         0.0%        63.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   0/10 (0%)    1/10 (10%) |  1/10 (10%)   0/10 (0%)    0/10 (0%)    2/10 (20%) |
|TERMINAL (d)           |  4/38 (11%)   3/11 (27%)   0/2 (0%)     0/1 (0%)   |  2/36 (6%)    1/4 (25%)    0/6 (0%)     2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      447          456 (I)   |   457 (I)      639          ---          457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.066      P=0.014 *    P=0.302      P=0.084    |  P<0.001 **   P=0.090      P=0.341N     P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.279N     P=0.309      P=0.125N     P=0.380N   |  P=0.004 **   P=0.483      P=0.341N     P=0.028 *  |
|LOGISTIC REGRESSION    |  P=0.345N     P=0.214      P=0.303N     P=0.508N   |  P=0.017 *    P=0.556      P=0.125N     P=0.086    |
|COCHRAN-ARMITAGE       |  P=0.278N                                          |  P=0.038 *                                         |
|FISHER EXACT           |               P=0.300      P=0.264N     P=0.500N   |               P=0.660N     P=0.125N     P=0.102    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)   10/58 (17%)   5/58 (9%)    2/58 (3%)  |  0/58 (0%)    5/58 (9%)    2/57 (4%)    1/57 (2%)  |
|ADJUSTED (b)           |   0.0%        53.2%        60.1%        12.3%      |   0.0%        37.1%        13.0%        25.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    4/11 (36%)   1/2 (50%)    0/1 (0%)   |  0/36 (0%)    0/4 (0%)     0/6 (0%)     1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   ---          590          548          599       |   ---          541          569          667 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.012 *    P<0.001 **   P<0.001 **   P=0.066    |  P=0.145      P<0.001 **   P=0.084      P=0.091    |
|INCIDENTAL TUMOR       |  P=0.370N     P<0.001 **   P=0.067      P=0.715    |  P=0.458N     P=0.306      P=0.583      P=0.091    |
|LOGISTIC REGRESSION    |  P=0.289N     P<0.001 **   P=0.010 **   P=0.151    |  P=0.461      P=0.016 *    P=0.184      P=0.091    |
|COCHRAN-ARMITAGE       |  P=0.449N                                          |  P=0.508N                                          |
|FISHER EXACT           |               P<0.001 **   P=0.029 *    P=0.248    |               P=0.029 *    P=0.243      P=0.496    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)   21/58 (36%)  27/58 (47%)  40/58 (69%) |  0/58 (0%)   28/58 (48%)  27/57 (47%)  34/57 (60%) |
|ADJUSTED (b)           |   0.0%        89.3%        95.6%       100.0%      |   0.0%       100.0%        95.5%        93.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    3/10 (30%) |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    9/11 (82%)   1/2 (50%)    1/1 (100%) |  0/36 (0%)    4/4 (100%)   5/6 (83%)    2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   ---          522          497          401       |   ---          457 (I)      481          468       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/58 (40%)  19/58 (33%)  16/58 (28%)  21/58 (36%) | 15/58 (26%)  19/58 (33%)  23/57 (40%)  17/57 (30%) |
|ADJUSTED (b)           |  48.0%        84.1%        72.7%        71.7%      |  37.2%        89.5%        93.6%        77.7%      |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   2/10 (20%)   4/10 (40%)   1/10 (10%) |  0/10 (0%)    2/10 (20%)   3/10 (30%)   2/10 (20%) |
|TERMINAL (d)           | 15/38 (39%)   8/11 (73%)   1/2 (50%)    0/1 (0%)   | 11/36 (31%)   3/4 (75%)    5/6 (83%)    2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   452          456 (I)      456 (I)      401       |   595          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.010 **   P=0.009 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.292      P=0.363      P=0.455N     P=0.295N   |  P=0.146      P=0.165      P=0.026 *    P=0.302    |
|LOGISTIC REGRESSION    |  P=0.360      P=0.543N     P=0.092N     P=0.548N   |  P=0.071      P=0.068      P=0.005 **   P=0.080    |
|COCHRAN-ARMITAGE       |  P=0.417N                                          |  P=0.376                                           |
|FISHER EXACT           |               P=0.281N     P=0.119N     P=0.424N   |               P=0.270      P=0.073      P=0.395    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/58 (22%)  24/58 (41%)  35/58 (60%)  28/58 (48%) |  4/58 (7%)   31/58 (53%)  23/57 (40%)  23/57 (40%) |
|ADJUSTED (b)           |  27.0%        66.1%        94.4%       100.0%      |  10.8%        95.3%        87.9%        74.0%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   4/10 (40%)   2/10 (20%)   2/10 (20%) |  0/10 (0%)    3/10 (30%)   1/10 (10%)   3/10 (30%) |
|TERMINAL (d)           |  5/38 (13%)   3/11 (27%)   1/2 (50%)    1/1 (100%) |  3/36 (8%)    3/4 (75%)    4/6 (67%)    1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      363          315       |   660          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.263      P=0.287      P=0.270      P=0.593N   |  P=0.037 *    P<0.001 **   P<0.001 **   P=0.003 ** |
|LOGISTIC REGRESSION    |  P=0.004 **   P=0.253      P<0.001 **   P=0.004 ** |  P=0.017 *    P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.004 **                                        |  P=0.006 **                                        |
|FISHER EXACT           |               P=0.023 *    P<0.001 **   P=0.003 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/58 (55%)  40/58 (69%)  45/58 (78%)  38/58 (66%) | 17/58 (29%)  38/58 (66%)  33/57 (58%)  33/57 (58%) |
|ADJUSTED (b)           |  61.7%        97.2%       100.0%       100.0%      |  42.2%       100.0%        95.9%        89.7%      |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   6/10 (60%)   6/10 (60%)   3/10 (30%) |  0/10 (0%)    5/10 (50%)   4/10 (40%)   5/10 (50%) |
|TERMINAL (d)           | 19/38 (50%)  10/11 (91%)   2/2 (100%)   1/1 (100%) | 13/36 (36%)   4/4 (100%)   5/6 (83%)    2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   452          456 (I)      363          315       |   595          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.363      P=0.080      P=0.241      P=0.335N   |  P=0.019 *    P<0.001 **   P=0.002 **   P=0.007 ** |
|LOGISTIC REGRESSION    |  P=0.095      P=0.033 *    P=0.055      P=0.139    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.179                                           |  P=0.014 *                                         |
|FISHER EXACT           |               P=0.090      P=0.009 **   P=0.171    |               P<0.001 **   P=0.002 **   P=0.002 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/58 (55%)  40/58 (69%)  45/58 (78%)  38/58 (66%) | 17/58 (29%)  38/58 (66%)  33/57 (58%)  33/57 (58%) |
|ADJUSTED (b)           |  61.7%        97.2%       100.0%       100.0%      |  42.2%       100.0%        95.9%        89.7%      |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   6/10 (60%)   6/10 (60%)   3/10 (30%) |  0/10 (0%)    5/10 (50%)   4/10 (40%)   5/10 (50%) |
|TERMINAL (d)           | 19/38 (50%)  10/11 (91%)   2/2 (100%)   1/1 (100%) | 13/36 (36%)   4/4 (100%)   5/6 (83%)    2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   452          456 (I)      363          315       |   595          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.363      P=0.080      P=0.241      P=0.335N   |  P=0.019 *    P<0.001 **   P=0.002 **   P=0.007 ** |
|LOGISTIC REGRESSION    |  P=0.095      P=0.033 *    P=0.055      P=0.139    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.179                                           |  P=0.014 *                                         |
|FISHER EXACT           |               P=0.090      P=0.009 **   P=0.171    |               P<0.001 **   P=0.002 **   P=0.002 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/58 (19%)   8/58 (14%)  13/58 (22%)   6/58 (10%) |  6/58 (10%)   1/58 (2%)    7/57 (12%)   3/57 (5%)  |
|ADJUSTED (b)           |  26.0%        41.7%        76.4%        24.6%      |  16.7%         1.9%        41.7%        30.2%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    1/10 (10%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  8/38 (21%)   3/11 (27%)   1/2 (50%)    0/1 (0%)   |  6/36 (17%)   0/4 (0%)     2/6 (33%)    1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      522          433          456 (I)   |   667 (T)      457 (I)      457 (I)      509       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.007 **   P=0.139      P<0.001 **   P=0.065    |  P=0.086      P=0.681N     P=0.015 *    P=0.162    |
|INCIDENTAL TUMOR       |  P=0.319N     P=0.533N     P=0.451      P=0.389N   |  P=0.224      P=0.681N     P=0.086      P=0.391    |
|LOGISTIC REGRESSION    |  P=0.419N     P=0.572N     P=0.225      P=0.327N   |  P=0.529N     P=0.122N     P=0.341      P=0.639    |
|COCHRAN-ARMITAGE       |  P=0.184N                                          |  P=0.395N                                          |
|FISHER EXACT           |               P=0.308N     P=0.410      P=0.147N   |               P=0.057N     P=0.487      P=0.254N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    5/58 (9%)    3/58 (5%)    2/58 (3%)  |  0/58 (0%)    1/58 (2%)    2/57 (4%)    1/57 (2%)  |
|ADJUSTED (b)           |   5.3%        28.4%        51.9%        20.0%      |   0.0%         2.5%        14.5%         5.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/38 (5%)    2/11 (18%)   0/2 (0%)     0/1 (0%)   |  0/36 (0%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   666 (T)      537          548          606       |   ---          541          615          597       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.014 *    P=0.015 *    P=0.004 **   P=0.043 *  |  P=0.124      P=0.477      P=0.063      P=0.342    |
|INCIDENTAL TUMOR       |  P=0.538      P=0.108      P=0.386      P=0.730    |  P=0.528      P=0.718      P=0.583      P=0.780    |
|LOGISTIC REGRESSION    |  P=0.294      P=0.077      P=0.127      P=0.293    |  P=0.287      P=0.540      P=0.132      P=0.468    |
|COCHRAN-ARMITAGE       |  P=0.420N                                          |  P=0.361                                           |
|FISHER EXACT           |               P=0.219      P=0.500      P=0.691N   |               P=0.500      P=0.243      P=0.496    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/58 (22%)  13/58 (22%)  16/58 (28%)   8/58 (14%) |  6/58 (10%)   2/58 (3%)    9/57 (16%)   4/57 (7%)  |
|ADJUSTED (b)           |  30.9%        61.8%        88.7%        39.7%      |  16.7%         4.3%        50.1%        33.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    1/10 (10%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 10/38 (26%)   5/11 (45%)   1/2 (50%)    0/1 (0%)   |  6/36 (17%)   0/4 (0%)     2/6 (33%)    1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      522          433          456 (I)   |   667 (T)      457 (I)      457 (I)      509       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.008 **   P<0.001 **   P=0.008 ** |  P=0.028 *    P=0.529      P=0.002 **   P=0.064    |
|INCIDENTAL TUMOR       |  P=0.366N     P=0.298      P=0.278      P=0.452N   |  P=0.205      P=0.643      P=0.062      P=0.327    |
|LOGISTIC REGRESSION    |  P=0.531N     P=0.238      P=0.088      P=0.489N   |  P=0.438      P=0.209N     P=0.137      P=0.480    |
|COCHRAN-ARMITAGE       |  P=0.153N                                          |  P=0.530N                                          |
|FISHER EXACT           |               P=0.588N     P=0.334      P=0.167N   |               P=0.136N     P=0.278      P=0.382N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)    0/58 (0%)    0/58 (0%)    1/58 (2%)  |  0/58 (0%)    2/58 (3%)    0/57 (0%)    0/58 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         3.7%      |   0.0%         7.6%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    0/11 (0%)    0/2 (0%)     0/1 (0%)   |  0/36 (0%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          565       |   ---          541          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.157        (e)          (e)        P=0.403    |  P=0.569N     P=0.158        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.346        (e)          (e)        P=0.877    |  P=0.253N     P=0.516        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.185        (e)          (e)        P=0.512    |  P=0.429N     P=0.236        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.198                                           |  P=0.405N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/57 (4%)    0/57 (0%)    0/55 (0%)    2/56 (4%)  |
|ADJUSTED (b)           |                                                    |   5.1%         0.0%         0.0%        12.3%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/36 (3%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |                                                    |   603          ---          ---          587       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.173      P=0.484N     P=0.505N     P=0.261    |
|INCIDENTAL TUMOR       |                                                    |  P=0.556      P=0.234N     P=0.240N     P=0.491N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.353      P=0.302N     P=0.333N     P=0.559    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.493                                           |
|FISHER EXACT           |                                                    |               P=0.248N     P=0.257N     P=0.684    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Luteoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/57 (4%)    0/57 (0%)    0/55 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |                                                    |   5.6%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  2/36 (6%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |                                                    |   667 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.434N     P=0.763N     P=0.669N     P=0.763N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.434N     P=0.763N     P=0.669N     P=0.763N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.434N     P=0.763N     P=0.669N     P=0.763N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.118N                                          |
|FISHER EXACT           |                                                    |               P=0.248N     P=0.257N     P=0.252N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/57 (0%)    0/53 (0%)    0/53 (0%)    0/54 (0%)  |  4/56 (7%)    5/55 (9%)    2/54 (4%)    6/56 (11%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  10.6%        55.3%        18.2%        53.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/9 (0%)     0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/37 (0%)    0/11 (0%)    0/2 (0%)     0/1 (0%)   |  3/36 (8%)    2/4 (50%)    0/6 (0%)     1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   617          585          652          565       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.002 **   P=0.018 *    P=0.374      P=0.002 ** |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.173      P=0.209      P=0.315N     P=0.395    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.053      P=0.222      P=0.645      P=0.079    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.353                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.488      P=0.357N     P=0.371    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)    0/58 (0%)    0/58 (0%)    0/58 (0%)  |  0/58 (0%)    0/58 (0%)    0/57 (0%)    2/58 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         8.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    0/11 (0%)    0/2 (0%)     0/1 (0%)   |  0/36 (0%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          366       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.022 *      (e)          (e)        P=0.136    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.082        (e)          (e)        P=0.526    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.077        (e)          (e)        P=0.335    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.047 *                                         |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.248    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    0/58 (0%)    0/56 (0%)    0/56 (0%)  |  0/58 (0%)    0/58 (0%)    0/56 (0%)    0/57 (0%)  |
|ADJUSTED (b)           |   5.3%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/38 (5%)    0/11 (0%)    0/2 (0%)     0/1 (0%)   |  0/36 (0%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   666 (T)      ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.604N     P=0.535N     P=0.906N     P=0.979N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.604N     P=0.535N     P=0.906N     P=0.979N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.604N     P=0.535N     P=0.906N     P=0.979N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.119N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.257N     P=0.257N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    1/58 (2%)    1/58 (2%)    2/58 (3%)  |  0/58 (0%)    1/58 (2%)    1/57 (2%)    0/58 (0%)  |
|ADJUSTED (b)           |   5.3%         2.9%         2.0%       100.0%      |   0.0%         6.3%         7.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/38 (5%)    0/11 (0%)    0/2 (0%)     1/1 (100%) |  0/36 (0%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   666 (T)      541          456 (I)      610       |   ---          639          636          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.056      P=0.693      P=0.568      P=0.006 ** |  P=0.503      P=0.333      P=0.307        (e)      |
|INCIDENTAL TUMOR       |  P=0.163      P=0.654N     P=0.568      P=0.098    |  P=0.403N     P=0.744      P=0.727        (e)      |
|LOGISTIC REGRESSION    |  P=0.406      P=0.612N     P=0.582N     P=0.133    |  P=0.634      P=0.416      P=0.402        (e)      |
|COCHRAN-ARMITAGE       |  P=0.556                                           |  P=0.595N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.691N   |               P=0.500      P=0.496        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    1/58 (2%)    1/58 (2%)    1/58 (2%)  |  0/58 (0%)    1/58 (2%)    1/57 (2%)    0/58 (0%)  |
|ADJUSTED (b)           |   5.3%         2.9%         2.0%       100.0%      |   0.0%         6.3%         7.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/38 (5%)    0/11 (0%)    0/2 (0%)     1/1 (100%) |  0/36 (0%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   666 (T)      541          456 (I)      666 (T)   |   ---          639          636          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272      P=0.693      P=0.568      P=0.056    |  P=0.503      P=0.333      P=0.307        (e)      |
|INCIDENTAL TUMOR       |  P=0.318      P=0.654N     P=0.568      P=0.056    |  P=0.403N     P=0.744      P=0.727        (e)      |
|LOGISTIC REGRESSION    |  P=0.535N     P=0.612N     P=0.582N     P=0.056    |  P=0.634      P=0.416      P=0.402        (e)      |
|COCHRAN-ARMITAGE       |  P=0.409N                                          |  P=0.595N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.500      P=0.496        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)    3/58 (5%)    0/57 (0%)    0/57 (0%)  |  3/58 (5%)    1/58 (2%)    1/56 (2%)    1/56 (2%)  |
|ADJUSTED (b)           |   0.0%        23.3%         0.0%         0.0%      |   7.2%         3.7%         5.0%         5.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    2/11 (18%)   0/2 (0%)     0/1 (0%)   |  2/36 (6%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          637          ---          ---       |   457 (I)      614          615          597       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.345      P=0.008 **     (e)          (e)      |  P=0.586      P=0.687N     P=0.674N     P=0.729N   |
|INCIDENTAL TUMOR       |  P=0.684N     P=0.039 *      (e)          (e)      |  P=0.303N     P=0.513N     P=0.478N     P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.588      P=0.020 *      (e)          (e)      |  P=0.324N     P=0.320N     P=0.345N     P=0.356N   |
|COCHRAN-ARMITAGE       |  P=0.316N                                          |  P=0.254N                                          |
|FISHER EXACT           |               P=0.122        (e)          (e)      |               P=0.309N     P=0.323N     P=0.323N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)    4/58 (7%)    0/57 (0%)    0/57 (0%)  |  3/58 (5%)    1/58 (2%)    1/56 (2%)    1/56 (2%)  |
|ADJUSTED (b)           |   0.0%        31.8%         0.0%         0.0%      |   7.2%         3.7%         5.0%         5.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    3/11 (27%)   0/2 (0%)     0/1 (0%)   |  2/36 (6%)    0/4 (0%)     0/6 (0%)     0/4 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          637          ---          ---       |   457 (I)      614          615          597       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.228      P=0.001 **     (e)          (e)      |  P=0.586      P=0.687N     P=0.674N     P=0.729N   |
|INCIDENTAL TUMOR       |  P=0.616      P=0.006 **     (e)          (e)      |  P=0.303N     P=0.513N     P=0.478N     P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.477      P=0.004 **     (e)          (e)      |  P=0.324N     P=0.320N     P=0.345N     P=0.356N   |
|COCHRAN-ARMITAGE       |  P=0.252N                                          |  P=0.254N                                          |
|FISHER EXACT           |               P=0.059        (e)          (e)      |               P=0.309N     P=0.323N     P=0.323N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)   11/58 (19%)   6/58 (10%)   3/58 (5%)  |  0/58 (0%)    5/58 (9%)    4/57 (7%)    1/58 (2%)  |
|ADJUSTED (b)           |   0.0%        54.7%        61.3%        26.9%      |   0.0%        37.1%        33.5%        25.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    4/11 (36%)   1/2 (50%)    0/1 (0%)   |  0/36 (0%)    0/4 (0%)     1/6 (17%)    1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   ---          566          541          599       |   ---          541          569          667 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005 **   P<0.001 **   P<0.001 **   P=0.005 ** |  P=0.054      P<0.001 **   P=0.002 **   P=0.091    |
|INCIDENTAL TUMOR       |  P=0.382N     P<0.001 **   P=0.062      P=0.598    |  P=0.570      P=0.306      P=0.108      P=0.091    |
|LOGISTIC REGRESSION    |  P=0.310N     P<0.001 **   P=0.006 **   P=0.040 *  |  P=0.307      P=0.016 *    P=0.015 *    P=0.091    |
|COCHRAN-ARMITAGE       |  P=0.562N                                          |  P=0.544N                                          |
|FISHER EXACT           |               P<0.001 **   P=0.014 *    P=0.122    |               P=0.029 *    P=0.057      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)   21/58 (36%)  27/58 (47%)  40/58 (69%) |  0/58 (0%)   28/58 (48%)  27/57 (47%)  34/58 (59%) |
|ADJUSTED (b)           |   5.3%        89.3%        95.6%       100.0%      |   0.0%       100.0%        95.5%        93.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    3/10 (30%) |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/38 (5%)    9/11 (82%)   1/2 (50%)    1/1 (100%) |  0/36 (0%)    4/4 (100%)   5/6 (83%)    2/4 (50%)  |
|FIRST INCIDENCE (DAYS) |   666 (T)      522          497          401       |   ---          457 (I)      481          468       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)   27/58 (47%)  30/58 (52%)  41/58 (71%) |  0/58 (0%)   32/58 (55%)  28/57 (49%)  35/58 (60%) |
|ADJUSTED (b)           |   5.3%        95.8%       100.0%       100.0%      |   0.0%       100.0%        96.0%        96.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    3/10 (30%) |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/38 (5%)   10/11 (91%)   2/2 (100%)   1/1 (100%) |  0/36 (0%)    4/4 (100%)   5/6 (83%)    3/4 (75%)  |
|FIRST INCIDENCE (DAYS) |   666 (T)      522          497          401       |   ---          457 (I)      481          468       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)   12/58 (21%)   7/58 (12%)   8/58 (14%) |  1/58 (2%)   21/58 (36%)  19/57 (33%)  18/58 (31%) |
|ADJUSTED (b)           |   0.0%        47.8%        34.5%        66.4%      |   1.7%        77.4%        51.1%        78.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    1/11 (9%)    0/2 (0%)     0/1 (0%)   |  0/36 (0%)    1/4 (25%)    0/6 (0%)     1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   ---          513          415          456 (I)   |   400          429          457 (I)      484       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.562N     P=0.016 *    P=0.204      P=0.103    |  P=0.135      P=0.007 **   P=0.016 *    P=0.010 ** |
|LOGISTIC REGRESSION    |  P=0.035 *    P<0.001 **   P=0.016 *    P=0.002 ** |  P=0.037 *    P<0.001 **   P=0.003 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.089                                           |  P=0.003 **                                        |
|FISHER EXACT           |               P<0.001 **   P=0.006 **   P=0.003 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    1/58 (2%)    0/58 (0%)    1/58 (2%)  |  5/58 (9%)    3/58 (5%)    0/57 (0%)    3/58 (5%)  |
|ADJUSTED (b)           |   5.1%         4.8%         0.0%        12.5%      |  12.8%        18.0%         0.0%        31.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  1/38 (3%)    0/11 (0%)    0/2 (0%)     0/1 (0%)   |  3/36 (8%)    0/4 (0%)     0/6 (0%)     1/4 (25%)  |
|FIRST INCIDENCE (DAYS) |   650          614          ---          623       |   595          530          ---          457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.266      P=0.651      P=0.840N     P=0.281    |  P=0.276      P=0.348      P=0.250N     P=0.229    |
|INCIDENTAL TUMOR       |  P=0.346N     P=0.393N     P=0.338N     P=0.561N   |  P=0.409N     P=0.227N     P=0.042N*    P=0.572N   |
|LOGISTIC REGRESSION    |  P=0.602      P=0.689N     P=0.618N     P=0.667    |  P=0.436N     P=0.514N     P=0.088N     P=0.582N   |
|COCHRAN-ARMITAGE       |  P=0.367N                                          |  P=0.250N                                          |
|FISHER EXACT           |               P=0.500N     P=0.248N     P=0.500N   |               P=0.358N     P=0.030N*    P=0.358N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/58 (55%)  34/58 (59%)  31/58 (53%)  30/58 (52%) | 29/58 (50%)  27/58 (47%)  30/57 (53%)  33/58 (57%) |
|ADJUSTED (b)           |  65.5%       100.0%       100.0%       100.0%      |  65.4%       100.0%        95.4%       100.0%      |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   4/10 (40%)   4/10 (40%)   3/10 (30%) |  2/10 (20%)   3/10 (30%)   4/10 (40%)   4/10 (40%) |
|TERMINAL (d)           | 22/38 (58%)  11/11 (100%)  2/2 (100%)   1/1 (100%) | 21/36 (58%)   4/4 (100%)   5/6 (83%)    4/4 (100%) |
|FIRST INCIDENCE (DAYS) |   452          456 (I)      433          401       |   457 (I)      457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.427      P=0.081      P=0.431      P=0.597N   |  P=0.014 *    P=0.331      P=0.210      P=0.082    |
|LOGISTIC REGRESSION    |  P=0.355      P=0.129      P=0.525      P=0.447    |  P=0.008 **   P=0.350      P=0.118      P=0.016 *  |
|COCHRAN-ARMITAGE       |  P=0.320N                                          |  P=0.190                                           |
|FISHER EXACT           |               P=0.426      P=0.500N     P=0.426N   |               P=0.426N     P=0.462      P=0.288    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/58 (31%)  43/58 (74%)  49/58 (84%)  50/58 (86%) | 14/58 (24%)  49/58 (84%)  46/57 (81%)  50/58 (86%) |
|ADJUSTED (b)           |  36.9%        95.3%       100.0%       100.0%      |  32.1%       100.0%       100.0%       100.0%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   4/10 (40%)   2/10 (20%)   4/10 (40%) |  0/10 (0%)    3/10 (30%)   1/10 (10%)   4/10 (40%) |
|TERMINAL (d)           |  8/38 (21%)   9/11 (82%)   2/2 (100%)   1/1 (100%) |  7/36 (19%)   4/4 (100%)   6/6 (100%)   4/4 (100%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      363          315       |   400          429          457 (I)      366       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P<0.001 **   P=0.025 *    P=0.011 *  |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 06                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 96 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      312 PPM      625 PPM      1250 PPM  |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 43/58 (74%)  51/58 (88%)  54/58 (93%)  52/58 (90%) | 36/58 (62%)  53/58 (91%)  50/57 (88%)  52/58 (90%) |
|ADJUSTED (b)           |  80.8%       100.0%       100.0%       100.0%      |  77.9%       100.0%       100.0%       100.0%      |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   7/10 (70%)   6/10 (60%)   6/10 (60%) |  2/10 (20%)   6/10 (60%)   5/10 (50%)   6/10 (60%) |
|TERMINAL (d)           | 28/38 (74%)  11/11 (100%)  2/2 (100%)   1/1 (100%) | 26/36 (72%)   4/4 (100%)   6/6 (100%)   4/4 (100%) |
|FIRST INCIDENCE (DAYS) |   452          456 (I)      363          315       |   400          429          457 (I)      366       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.095      P=0.050      P=0.262      P=0.306    |  P<0.001 **   P<0.001 **   P=0.002 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.003 **   P=0.004 **   P=0.003 **   P=0.003 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.020 *                                         |  P=0.001 **                                        |
|FISHER EXACT           |               P=0.048 *    P=0.005 **   P=0.026 *  |               P<0.001 **   P=0.001 **   P<0.001 ** |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).