National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2280

TDMS Study 05132-05 Pathology Tables

NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05




       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  08/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           33           31           25                                     
    Natural Death                                      1            1            4            6                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           15           15           18                                     
    Moribund Sacrifice                                              1                                                               

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
      Cyst                                                                       1 (2%)                                             
      Parasite Metazoan                                4 (7%)       5 (8%)       3 (5%)       3 (5%)                                
   Intestine Large, Rectum                            (60)         (60)         (59)         (60)                                   
      Diverticulum                                     1 (2%)                                                                       
      Parasite Metazoan                                5 (8%)       2 (3%)       2 (3%)       6 (10%)                               
   Intestine Large, Cecum                             (60)         (60)         (59)         (60)                                   
      Diverticulum                                     1 (2%)                                                                       
      Fibrosis                                                                                1 (2%)                                
      Infiltration Cellular, Eosinophil                1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)       1 (2%)                    4 (7%)                                
   Intestine Small, Duodenum                          (59)         (60)         (59)         (60)                                   
      Necrosis                                                                   1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                                  10 (17%)      9 (15%)     14 (23%)                               
      Basophilic Focus                                50 (83%)     47 (78%)     51 (85%)     47 (78%)                               
      Clear Cell Focus                                10 (17%)      5 (8%)      15 (25%)     12 (20%)                               
      Degeneration, Cystic                             1 (2%)       4 (7%)       1 (2%)       3 (5%)                                
      Embolus Bacterial                                                                       1 (2%)                                
      Eosinophilic Focus                               1 (2%)       9 (15%)      7 (12%)      4 (7%)                                
      Fatty Change                                    15 (25%)     20 (33%)     17 (28%)     10 (17%)                               
      Hepatodiaphragmatic Nodule                       3 (5%)       7 (12%)     10 (17%)      6 (10%)                               
      Mitotic Alteration                                                         1 (2%)                                             
      Mixed Cell Focus                                12 (20%)     15 (25%)     22 (37%)     22 (37%)                               
      Necrosis, Focal                                  1 (2%)                    2 (3%)                                             
      Regeneration                                     1 (2%)       2 (3%)       3 (5%)       8 (13%)                               
      Bile Duct, Hyperplasia                          10 (17%)     18 (30%)     12 (20%)     18 (30%)                               
      Centrilobular, Necrosis                                                    2 (3%)       2 (3%)                                
   Mesentery                                          (8)          (6)          (7)          (7)                                    
      Polyarteritis                                    1 (13%)                   1 (14%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    6 (75%)      6 (100%)     7 (100%)     5 (71%)                               
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Basophilic Focus                                 3 (5%)       1 (2%)       2 (3%)       1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Metaplasia                                                    1 (2%)                                                          
      Metaplasia, Hepatocyte                                                                  2 (3%)                                
      Acinus, Atrophy                                 18 (30%)     15 (25%)     11 (19%)     12 (20%)                               
   Pharynx                                                         (1)                                                              
      Palate, Hyperplasia                                           1 (100%)                                                        
   Stomach, Forestomach                               (60)         (60)         (58)         (60)                                   
      Acanthosis                                       4 (7%)       4 (7%)       2 (3%)       1 (2%)                                
      Diverticulum                                                  1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis                                         5 (8%)       4 (7%)                                                          
      Ulcer                                                                      1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
      Mineralization                                   1 (2%)                    1 (2%)       2 (3%)                                
      Necrosis                                         2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
   Tongue                                             (2)                       (2)          (1)                                    
      Hyperplasia, Squamous                                                      1 (50%)                                            
      Epithelium, Hyperplasia                                                    1 (50%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  49 (82%)     50 (83%)     49 (82%)     43 (72%)                               
      Embolus Bacterial                                                                       1 (2%)                                
      Polyarteritis                                    1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)       2 (3%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Embolus Bacterial                                                                       1 (2%)                                
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                     19 (32%)     12 (20%)     17 (28%)     24 (40%)                               
      Hypertrophy                                      6 (10%)      4 (7%)       3 (5%)       5 (8%)                                
      Metaplasia, Osseous                                                        1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Vacuolization Cytoplasmic                        5 (8%)       3 (5%)       4 (7%)       3 (5%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Embolus Bacterial                                                                       1 (2%)                                
      Hyperplasia                                      6 (10%)      9 (15%)      3 (5%)       8 (13%)                               
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (58)         (59)         (59)         (57)                                   
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (59)         (60)                                   
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      10 (17%)     13 (22%)     16 (27%)     20 (33%)                               
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Hyperplasia                             57 (95%)     47 (78%)     50 (83%)     47 (78%)                               
      Follicular Cell, Hyperplasia                     2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (59)         (60)         (58)                                   
      Dilatation                                       1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Inflammation, Chronic Active                     3 (5%)       4 (7%)       8 (13%)      2 (3%)                                
      Duct, Ectasia                                    1 (2%)                                                                       
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                             4 (7%)       4 (7%)       3 (5%)       2 (3%)                                
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hyperplasia, Reticulum Cell                      2 (3%)       2 (3%)       3 (5%)       3 (5%)                                
      Myelofibrosis                                                 3 (5%)       1 (2%)                                             
   Lymph Node                                         (3)          (8)          (7)          (13)                                   
      Lumbar, Pigmentation                                          1 (13%)                                                         
      Renal, Hemorrhage                                1 (33%)      1 (13%)      1 (14%)      2 (15%)                               
   Lymph Node, Bronchial                              (59)         (58)         (59)         (54)                                   
      Hemorrhage                                                                 2 (3%)                                             
   Lymph Node, Mandibular                             (58)         (58)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)       2 (3%)                                                          
      Infiltration Cellular, Plasma Cell                                         3 (5%)       2 (3%)                                
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
      Embolus Bacterial                                                                       1 (2%)                                
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
   Lymph Node, Mediastinal                            (57)         (59)         (59)         (54)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       4 (7%)       5 (8%)       3 (5%)       2 (4%)                                
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Developmental Malformation                                    1 (2%)                                                          
      Fibrosis                                         1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Infiltration Cellular, Lipocyte                               2 (3%)                                                          
   Thymus                                             (57)         (58)         (59)         (58)                                   
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Focal                                            1 (2%)                                                          
   Skin                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                                  2 (3%)       4 (7%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                     6 (10%)     14 (23%)      8 (13%)      3 (5%)                                
      Tibia, Fracture                                                                         1 (2%)                                
      Turbinate, Fracture                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     30 (50%)     23 (38%)     20 (33%)     19 (32%)                               
      Embolus Bacterial                                                                       1 (2%)                                
      Hemorrhage                                                    2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                    15 (25%)     17 (28%)     19 (32%)     24 (40%)                               
      Metaplasia, Squamous                             2 (3%)       3 (5%)       3 (5%)       5 (8%)                                
      Mineralization                                  38 (63%)     35 (58%)     41 (68%)     40 (67%)                               
   Lung                                               (60)         (60)         (60)         (60)                                   
      Hemorrhage                                      27 (45%)     18 (30%)     22 (37%)     15 (25%)                               
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                3 (5%)       1 (2%)       3 (5%)       3 (5%)                                
      Inflammation, Chronic Active                     2 (3%)       3 (5%)       1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Metaplasia, Osseous                                                                     1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 9 (15%)      5 (8%)      11 (18%)      6 (10%)                               
      Mediastinum, Polyarteritis                       1 (2%)                                                                       
   Nose                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       2 (3%)       3 (5%)       5 (8%)                                
      Thrombosis                                                                              1 (2%)                                
      Nares, Inflammation, Chronic Active                                                     1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (51)         (50)         (50)         (50)                                   
      Cataract                                        16 (31%)      4 (8%)      10 (20%)     45 (90%)                               
      Degeneration                                     2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
      Hemorrhage                                       3 (6%)       3 (6%)       2 (4%)       3 (6%)                                
      Cornea, Inflammation, Chronic Active             1 (2%)       2 (4%)                                                          
      Cornea, Mineralization                           1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Retina, Atrophy                                 22 (43%)     11 (22%)     15 (30%)     21 (42%)                               
      Retina, Degeneration                            33 (65%)     23 (46%)     14 (28%)     13 (26%)                               
   Harderian Gland                                    (1)          (1)                                                              
      Inflammation, Chronic Active                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Embolus Bacterial                                                                       1 (2%)                                
      Hyperplasia, Atypical                                                                   1 (2%)                                
      Nephropathy                                     56 (93%)     55 (92%)     57 (95%)     57 (95%)                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Dilatation                                            1 (2%)                    1 (2%)                                
      Renal Tubule, Degeneration                                                45 (75%)     56 (93%)                               
      Renal Tubule, Hyperplasia                        1 (2%)       3 (5%)       7 (12%)     12 (20%)                               
      Renal Tubule, Hyperplasia, Oncocytic                                                    4 (7%)                                
   Urinary Bladder                                    (59)         (60)         (60)         (59)                                   
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)                    1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            4            1            1                                     
    Moribund Sacrifice                                27           34           32           48                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                17           12           17            1                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Mineralization                                   1 (2%)                    2 (3%)       1 (2%)                                
      Parasite Metazoan                                2 (3%)       1 (2%)                    3 (5%)                                
   Intestine Large, Rectum                            (59)         (60)         (60)         (60)                                   
      Parasite Metazoan                                3 (5%)       1 (2%)                    2 (3%)                                
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Parasite Metazoan                                             2 (3%)       1 (2%)                                             
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (59)         (59)         (60)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Peyer's Patch, Inflammation, Granulomatous                                              1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                                   3 (5%)       2 (3%)       3 (5%)                                
      Basophilic Focus                                28 (47%)     23 (38%)     40 (67%)     33 (55%)                               
      Clear Cell Focus                                11 (18%)     18 (30%)     20 (33%)     13 (22%)                               
      Congestion                                                                              1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Degeneration, Cystic                            17 (28%)     40 (67%)     38 (63%)     32 (53%)                               
      Eosinophilic Focus                               4 (7%)      18 (30%)     22 (37%)     20 (33%)                               
      Fatty Change                                     5 (8%)       3 (5%)       4 (7%)       5 (8%)                                
      Fibrosis                                                                                1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (5%)       2 (3%)       4 (7%)       5 (8%)                                
      Hyperplasia                                                                             1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Mixed Cell Focus                                 5 (8%)       7 (12%)     18 (30%)     15 (25%)                               
      Necrosis, Focal                                                            1 (2%)                                             
      Regeneration                                     3 (5%)       4 (7%)       1 (2%)       1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          51 (85%)     52 (87%)     50 (83%)     45 (75%)                               
      Centrilobular, Necrosis                          3 (5%)       1 (2%)       1 (2%)                                             
      Serosa, Fibrosis                                                           1 (2%)                                             
   Mesentery                                          (17)         (11)         (20)         (18)                                   
      Inflammation, Suppurative                        2 (12%)                                                                      
      Fat, Hemorrhage                                  2 (12%)                   3 (15%)      1 (6%)                                
      Fat, Necrosis                                   12 (71%)     11 (100%)    18 (90%)     15 (83%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                              4 (7%)       3 (5%)       4 (7%)                                
      Hyperplasia                                      3 (5%)       1 (2%)       4 (7%)                                             
      Acinus, Atrophy                                 36 (60%)     32 (53%)     33 (55%)     24 (40%)                               
      Duct, Concretion                                 1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                       2 (3%)       1 (2%)       2 (3%)       5 (8%)                                
      Diverticulum                                     2 (3%)       1 (2%)       2 (3%)                                             
      Infiltration Cellular, Mast Cell                 1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)                    2 (3%)       3 (5%)                                
      Necrosis                                         6 (10%)      4 (7%)       1 (2%)       6 (10%)                               
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Mineralization                                   2 (3%)       3 (5%)       4 (7%)      13 (22%)                               
      Necrosis                                         5 (8%)       3 (5%)                    3 (5%)                                
   Tongue                                             (1)          (1)                       (1)                                    
      Epithelium, Hyperplasia                                                                 1 (100%)                              
   Tooth                                              (2)          (2)          (1)          (2)                                    
      Dysplasia                                        2 (100%)     2 (100%)     1 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (3)          (12)                                   
      Mineralization                                   1 (100%)                  2 (67%)      3 (25%)                               
      Aorta, Mineralization                            1 (100%)                  3 (100%)    12 (100%)                              
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  56 (93%)     54 (90%)     53 (88%)     58 (97%)                               
      Mineralization                                   1 (2%)                    2 (3%)       4 (7%)                                
      Atrium, Thrombosis                               2 (3%)       3 (5%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Hyperplasia                                     17 (28%)     15 (25%)     22 (37%)     19 (32%)                               
      Hypertrophy                                      4 (7%)       4 (7%)       5 (8%)       4 (7%)                                
      Vacuolization Cytoplasmic                        2 (3%)                                                                       
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                     24 (40%)     21 (35%)     23 (38%)     27 (45%)                               
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (60)         (60)         (60)         (59)                                   
      Hyperplasia                                      1 (2%)       3 (5%)       7 (12%)     25 (42%)                               
   Pituitary Gland                                    (60)         (58)         (59)         (59)                                   
      Thrombosis                                                    1 (2%)                                                          
      Pars Distalis, Angiectasis                                                 1 (2%)                                             
      Pars Distalis, Hyperplasia                      10 (17%)      6 (10%)      8 (14%)     15 (25%)                               
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Hyperplasia                             26 (43%)     30 (50%)     40 (67%)     26 (43%)                               
      Follicular Cell, Hyperplasia                     2 (3%)                                 2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Granuloma Sperm                                                            1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
   Preputial Gland                                    (60)         (60)         (60)         (59)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                    13 (22%)     16 (27%)     17 (28%)     20 (34%)                               
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Duct, Ectasia                                    1 (2%)                    1 (2%)                                             
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                     2 (3%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                             2 (3%)       1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
      Atrophy                                          2 (3%)       3 (5%)       2 (3%)                                             
      Interstitial Cell, Hyperplasia                  10 (17%)     14 (23%)      6 (10%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hyperplasia, Reticulum Cell                      1 (2%)                    1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
   Lymph Node                                         (11)         (17)         (16)         (17)                                   
      Iliac, Pigmentation                                                                     1 (6%)                                
      Lumbar, Hemorrhage                                                                      2 (12%)                               
      Pancreatic, Edema                                                                       1 (6%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Edema                                                                            2 (12%)                               
      Renal, Hemorrhage                                                                       1 (6%)                                
      Renal, Pigmentation                                                                     1 (6%)                                
   Lymph Node, Bronchial                              (55)         (60)         (56)         (57)                                   
      Hemorrhage                                                                              1 (2%)                                
   Lymph Node, Mandibular                             (60)         (57)         (59)         (56)                                   
      Hemorrhage                                       1 (2%)       2 (4%)                                                          
      Infiltration Cellular, Plasma Cell               2 (3%)                    5 (8%)       2 (4%)                                
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
      Edema                                                         1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                    2 (3%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Lymph Node, Mediastinal                            (59)         (57)         (58)         (56)                                   
      Hemorrhage                                       5 (8%)       2 (4%)       2 (3%)       4 (7%)                                
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                       4 (7%)       3 (5%)       2 (3%)       4 (7%)                                
      Fibrosis                                         9 (15%)     14 (23%)     11 (18%)      6 (10%)                               
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)       2 (3%)                                
      Infiltration Cellular, Lipocyte                               1 (2%)                                                          
      Capsule, Fibrosis                                1 (2%)                    2 (3%)                                             
   Thymus                                             (56)         (57)         (57)         (54)                                   
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (43)         (45)         (39)                                   
      Galactocele                                      1 (3%)                    1 (2%)       1 (3%)                                
      Inflammation, Chronic Active                     1 (3%)       1 (2%)                                                          
   Skin                                               (59)         (60)         (60)         (60)                                   
      Acanthosis                                                                              1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                   1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                     9 (15%)      5 (8%)       5 (8%)       4 (7%)                                
      Necrosis                                                                                1 (2%)                                
      Prepuce, Edema                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                     1 (2%)       1 (2%)       1 (2%)                                             
      Cranium, Fibrous Osteodystrophy                  1 (2%)       1 (2%)       3 (5%)      17 (28%)                               
      Femur, Fibrous Osteodystrophy                    1 (2%)       1 (2%)       3 (5%)      19 (32%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Sternum, Developmental Malformation                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     12 (20%)     11 (18%)      9 (15%)      6 (10%)                               
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                    14 (23%)     14 (23%)     13 (22%)     19 (32%)                               
      Metaplasia, Squamous                             1 (2%)       1 (2%)       2 (3%)                                             
      Mineralization                                  42 (70%)     46 (77%)     44 (73%)     42 (70%)                               
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                      19 (32%)     15 (25%)     13 (22%)     18 (30%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia, Osseous                                                                     1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)       3 (5%)      12 (20%)                               
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 6 (10%)      6 (10%)      6 (10%)      3 (5%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Suppurative                        5 (8%)       3 (5%)       4 (7%)       7 (12%)                               
      Thrombosis                                       2 (3%)                                 1 (2%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                              1 (2%)                                
      Olfactory Epithelium, Degeneration                                                      1 (2%)                                
      Respiratory Epithelium, Hyperplasia              1 (2%)                                                                       
      Respiratory Epithelium, Metaplasia, Squamous     2 (3%)                                                                       
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Metaplasia, Squamous                             1 (2%)                                 1 (2%)                                
      Mineralization                                   1 (2%)                    2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (45)         (42)         (48)         (42)                                   
      Cataract                                         3 (7%)                    4 (8%)                                             
      Degeneration                                                  1 (2%)       4 (8%)                                             
      Cornea, Inflammation, Chronic Active                          1 (2%)                    4 (10%)                               
      Cornea, Mineralization                           1 (2%)                    2 (4%)       7 (17%)                               
      Retina, Atrophy                                  3 (7%)       2 (5%)       5 (10%)      2 (5%)                                
   Harderian Gland                                                 (1)                                                              
      Hypertrophy                                                   1 (100%)                                                        

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05132-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:05  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Developmental Malformation                                                              1 (2%)                                
      Infarct                                                       3 (5%)                                                          
      Mineralization                                                1 (2%)       3 (5%)       4 (7%)                                
      Nephropathy                                     59 (98%)     60 (100%)    60 (100%)    60 (100%)                              
      Pelvis, Dilatation                                                         1 (2%)                                             
      Renal Tubule, Degeneration                       3 (5%)      28 (47%)     60 (100%)    59 (98%)                               
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)       2 (3%)       7 (12%)                               
      Renal Tubule, Hyperplasia, Oncocytic                                       1 (2%)                                             
   Urinary Bladder                                    (59)         (60)         (60)         (60)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.