National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3397

TDMS Study 05132-05 Pathology Tables

NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06




       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  08/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           33           31           25                                     
    Natural Death                                      1            1            4            6                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           15           15           18                                     
    Moribund Sacrifice                                              1                                                               

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
   Intestine Large, Rectum                            (60)         (60)         (59)         (60)                                   
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Intestine Large, Cecum                             (60)         (60)         (59)         (60)                                   
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
   Intestine Small, Duodenum                          (59)         (60)         (59)         (60)                                   
   Intestine Small, Jejunum                           (60)         (60)         (57)         (59)                                   
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
   Intestine Small, Ileum                             (60)         (59)         (58)         (59)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            5 (8%)       1 (2%)                                
      Hepatocellular Carcinoma                                      4 (7%)       6 (10%)      2 (3%)                                
      Hepatocellular Carcinoma, Multiple                                         3 (5%)                                             
      Hepatocellular Adenoma                                        3 (5%)       4 (7%)       5 (8%)                                
      Hepatocellular Adenoma, Multiple                              1 (2%)       1 (2%)       1 (2%)                                
      Sarcoma                                                                    1 (2%)                                             
   Mesentery                                          (8)          (6)          (7)          (7)                                    
      Leiomyosarcoma, Metastatic, Uterus               1 (13%)                                                                      
   Pancreas                                           (60)         (60)         (59)         (60)                                   
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (58)         (60)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
   Tongue                                             (2)                       (2)          (1)                                    
      Squamous Cell Papilloma                          2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma NOS                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma, Metastatic, Liver                                         1 (2%)                                             
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          4 (7%)       1 (2%)       2 (3%)       5 (8%)                                
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Parathyroid Gland                                  (58)         (59)         (59)         (57)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (60)         (60)         (59)         (60)                                   
      Pars Distalis, Adenoma                          44 (73%)     36 (60%)     37 (63%)     34 (57%)                               
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Adenoma                                  5 (8%)       9 (15%)      5 (8%)       2 (3%)                                
      C-Cell, Carcinoma                                2 (3%)       2 (3%)       3 (5%)       2 (3%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Abdominal, Fat, Hemangiosarcoma, Metastatic,                                                                                  
           Tissue NOS                                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (59)         (60)         (58)                                   
      Adenoma                                          6 (10%)      7 (12%)      2 (3%)                                             
      Carcinoma                                        1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Granulosa-Theca Tumor Benign                                               1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Leiomyosarcoma                                   1 (2%)       1 (2%)                                                          
      Polyp Stromal                                    5 (8%)       4 (7%)       6 (10%)      6 (10%)                               
      Polyp Stromal, Multiple                          1 (2%)       1 (2%)                                                          
      Sarcoma Stromal                                               1 (2%)                    1 (2%)                                
   Vagina                                             (1)                       (1)          (1)                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp                                            1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              2 (3%)                                                                       
   Lymph Node                                         (3)          (8)          (7)          (13)                                   
      Iliac, Osteosarcoma, Metastatic, Bone                                                   1 (8%)                                
   Lymph Node, Bronchial                              (59)         (58)         (59)         (54)                                   
   Lymph Node, Mandibular                             (58)         (58)         (60)         (60)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
   Lymph Node, Mediastinal                            (57)         (59)         (59)         (54)                                   
   Spleen                                             (60)         (60)         (59)         (60)                                   
   Thymus                                             (57)         (58)         (59)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
      Carcinoma                                        3 (5%)       1 (2%)       3 (5%)       1 (2%)                                
      Carcinoma, Multiple                                                        1 (2%)                                             
      Fibroadenoma                                    17 (28%)     10 (17%)      8 (13%)      6 (10%)                               
      Fibroadenoma, Multiple                           5 (8%)       1 (2%)       1 (2%)       2 (3%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basosquamous Tumor Malignant                                               1 (2%)       1 (2%)                                
      Keratoacanthoma                                  2 (3%)                                 1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Neurofibroma                                                       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
      Vertebra, Sarcoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma NOS                                               1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (60)         (60)         (60)         (60)                                   
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                    1 (2%)                                
      Hemangiosarcoma, Metastatic, Liver                                         3 (5%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                2 (3%)                                             
      Histiocytic Sarcoma, Metastatic, Bone Marrow     1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
      Sarcoma, Metastatic, Liver                                                 1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
   Trachea                                            (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (51)         (50)         (50)         (50)                                   
   Zymbal's Gland                                                               (1)          (1)                                    
      Adenoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
      Mixed Tumor Malignant                                                                   1 (2%)                                
      Renal Tubule, Adenoma                                         3 (5%)       1 (2%)       4 (7%)                                
      Renal Tubule, Carcinoma                                                                 2 (3%)                                
   Urinary Bladder                                    (59)         (60)         (60)         (59)                                   
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Transitional Epithelium, Papilloma                                         2 (3%)                                             
                                                                                                                                    

                                                             Page   5                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Leukemia Mononuclear                            16 (27%)     31 (52%)     23 (38%)     36 (60%)                               
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          54          52          51                                       
     Total Primary Neoplasms                          123         127         124         122                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          46          46          43                                       
     Total Benign Neoplasms                            94          78          75          71                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          42          35          43                                       
     Total Malignant Neoplasms                         28          48          49          50                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           8           3                                       
     Total Metastatic Neoplasm                          7           4           9           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1                       1                                       
     Total Uncertain Neoplasms                          1           1                       1                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            4            1            1                                     
    Moribund Sacrifice                                27           34           32           48                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                17           12           17            1                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
   Intestine Small, Jejunum                           (58)         (57)         (59)         (60)                                   
   Intestine Small, Ileum                             (59)         (59)         (60)         (60)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Carcinoma                         1 (2%)       1 (2%)      10 (17%)      4 (7%)                                
      Hepatocellular Adenoma                           2 (3%)       3 (5%)       6 (10%)      4 (7%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)       3 (5%)       3 (5%)       1 (2%)                                
      Hepatocholangioma                                             1 (2%)                                                          
   Mesentery                                          (17)         (11)         (20)         (18)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (6%)                                
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Acinus, Adenoma                                               2 (3%)       1 (2%)       1 (2%)                                
   Pharynx                                            (1)                                                                           
      Palate, Squamous Cell Carcinoma                  1 (100%)                                                                     
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
   Tongue                                             (1)          (1)                       (1)                                    
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma NOS                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                                    2 (3%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Ganglioneuroma                                                                          1 (2%)                                
      Pheochromocytoma Malignant                       2 (3%)                    1 (2%)                                             
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                         15 (25%)      8 (13%)      8 (13%)      6 (10%)                               
      Bilateral, Pheochromocytoma Benign               4 (7%)       3 (5%)       1 (2%)       4 (7%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
      Carcinoma                                        1 (2%)       5 (8%)       1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (60)         (60)         (60)         (59)                                   
   Pituitary Gland                                    (60)         (58)         (59)         (59)                                   
      Pars Distalis, Adenoma                          41 (68%)     40 (69%)     36 (61%)     27 (46%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Intermedia, Adenoma                         2 (3%)                                                                       
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Adenoma                                  7 (12%)      8 (13%)      5 (8%)       4 (7%)                                
      C-Cell, Carcinoma                                2 (3%)       1 (2%)       4 (7%)       1 (2%)                                
      Follicular Cell, Adenoma                         2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
   Preputial Gland                                    (60)         (60)         (60)         (59)                                   
      Adenoma                                          1 (2%)       3 (5%)       5 (8%)       2 (3%)                                
      Carcinoma                                        4 (7%)       3 (5%)       1 (2%)       4 (7%)                                
      Bilateral, Carcinoma                                                       1 (2%)                                             
   Prostate                                           (60)         (60)         (60)         (60)                                   
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
   Testes                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           42 (70%)     42 (70%)     50 (83%)     51 (85%)                               
      Interstitial Cell, Adenoma                       6 (10%)      5 (8%)       8 (13%)      6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (11)         (17)         (16)         (17)                                   
   Lymph Node, Bronchial                              (55)         (60)         (56)         (57)                                   
   Lymph Node, Mandibular                             (60)         (57)         (59)         (56)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
   Lymph Node, Mediastinal                            (59)         (57)         (58)         (56)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
   Thymus                                             (56)         (57)         (57)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (43)         (45)         (39)                                   
      Adenoma                                                                                 1 (3%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Fibroadenoma                                     2 (5%)       2 (5%)       2 (4%)       1 (3%)                                
   Skin                                               (59)         (60)         (60)         (60)                                   
      Basosquamous Tumor Benign                        2 (3%)                                 1 (2%)                                
      Keratoacanthoma                                  3 (5%)                    1 (2%)       1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     3 (5%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Neurofibroma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma                                     1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Meningioma NOS                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (60)         (60)         (60)         (60)                                   
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (2%)       2 (3%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Chordoma, Metastatic, Uncertain Primary Site                  1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
   Trachea                                            (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Renal Tubule, Adenoma                                           1 (2%)                                             
      Renal Tubule, Adenoma                                                      5 (8%)       3 (5%)                                
      Renal Tubule, Carcinoma                          1 (2%)                    2 (3%)       1 (2%)                                
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
   Urinary Bladder                                    (59)         (60)         (60)         (60)                                   
      Transitional Epithelium, Papilloma                            4 (7%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            34 (57%)     43 (72%)     38 (63%)     32 (53%)                               
      Mesothelioma Malignant                           5 (8%)       1 (2%)       2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05132-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:24:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      156 PPM      312 PPM      625 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          58          60          59                                       
     Total Primary Neoplasms                          193         187         207         167                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 59          57          60          59                                       
     Total Benign Neoplasms                           140         129         139         120                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          46          49          39                                       
     Total Malignant Neoplasms                         53          57          67          47                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1           2                                       
     Total Metastatic Neoplasm                          1           1           1           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                       1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           1                                                   
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.