TDMS Study 05132-05 Pathology Tables
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
Facility: Battelle Northwest
Chemical CAS #: 116-14-3
Lock Date: 08/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 21 33 31 25
Natural Death 1 1 4 6
Accidently Killed 1
Survivors
Terminal Sacrifice 28 15 15 18
Moribund Sacrifice 1
Animals Examined Microscopically 60 60 60 60
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ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (59) (60)
Intestine Large, Rectum (60) (60) (59) (60)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Intestine Large, Cecum (60) (60) (59) (60)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Intestine Small, Duodenum (59) (60) (59) (60)
Intestine Small, Jejunum (60) (60) (57) (59)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Intestine Small, Ileum (60) (59) (58) (59)
Liver (60) (60) (60) (60)
Hemangiosarcoma 5 (8%) 1 (2%)
Hepatocellular Carcinoma 4 (7%) 6 (10%) 2 (3%)
Hepatocellular Carcinoma, Multiple 3 (5%)
Hepatocellular Adenoma 3 (5%) 4 (7%) 5 (8%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Mesentery (8) (6) (7) (7)
Leiomyosarcoma, Metastatic, Uterus 1 (13%)
Pancreas (60) (60) (59) (60)
Salivary Glands (60) (60) (60) (60)
Adenoma 1 (2%)
Stomach, Forestomach (60) (60) (58) (60)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (60) (60) (59) (60)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Tongue (2) (2) (1)
Squamous Cell Papilloma 2 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Schwannoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Adrenal Medulla (60) (60) (60) (60)
Pheochromocytoma Benign 4 (7%) 1 (2%) 2 (3%) 5 (8%)
Islets, Pancreatic (60) (60) (59) (60)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (58) (59) (59) (57)
Adenoma 1 (2%)
Pituitary Gland (60) (60) (59) (60)
Pars Distalis, Adenoma 44 (73%) 36 (60%) 37 (63%) 34 (57%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Adenoma 5 (8%) 9 (15%) 5 (8%) 2 (3%)
C-Cell, Carcinoma 2 (3%) 2 (3%) 3 (5%) 2 (3%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Abdominal, Fat, Hemangiosarcoma, Metastatic,
Tissue NOS 1 (100%)
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GENITAL SYSTEM
Clitoral Gland (59) (59) (60) (58)
Adenoma 6 (10%) 7 (12%) 2 (3%)
Carcinoma 1 (2%) 2 (3%) 2 (3%) 2 (3%)
Ovary (60) (60) (60) (60)
Granulosa-Theca Tumor Benign 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Uterus (60) (60) (60) (60)
Leiomyosarcoma 1 (2%) 1 (2%)
Polyp Stromal 5 (8%) 4 (7%) 6 (10%) 6 (10%)
Polyp Stromal, Multiple 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%) 1 (2%)
Vagina (1) (1) (1)
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NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Polyp 1 (100%) 1 (100%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Histiocytic Sarcoma 2 (3%)
Lymph Node (3) (8) (7) (13)
Iliac, Osteosarcoma, Metastatic, Bone 1 (8%)
Lymph Node, Bronchial (59) (58) (59) (54)
Lymph Node, Mandibular (58) (58) (60) (60)
Lymph Node, Mesenteric (60) (60) (60) (60)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Lymph Node, Mediastinal (57) (59) (59) (54)
Spleen (60) (60) (59) (60)
Thymus (57) (58) (59) (58)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 3 (5%) 1 (2%) 3 (5%) 1 (2%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 17 (28%) 10 (17%) 8 (13%) 6 (10%)
Fibroadenoma, Multiple 5 (8%) 1 (2%) 1 (2%) 2 (3%)
Skin (60) (60) (60) (60)
Basosquamous Tumor Malignant 1 (2%) 1 (2%)
Keratoacanthoma 2 (3%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Vertebra, Osteosarcoma 1 (2%)
Vertebra, Sarcoma 1 (2%)
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Page 4
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma NOS 1 (2%) 1 (2%)
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RESPIRATORY SYSTEM
Larynx (60) (60) (60) (60)
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Liver 3 (5%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (3%)
Histiocytic Sarcoma, Metastatic, Bone Marrow 1 (2%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Liver 1 (2%)
Nose (60) (60) (60) (60)
Trachea (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (51) (50) (50) (50)
Zymbal's Gland (1) (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Mixed Tumor Malignant 1 (2%)
Renal Tubule, Adenoma 3 (5%) 1 (2%) 4 (7%)
Renal Tubule, Carcinoma 2 (3%)
Urinary Bladder (59) (60) (60) (59)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Papilloma 2 (3%)
Page 5
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 2 (3%)
Leukemia Mononuclear 16 (27%) 31 (52%) 23 (38%) 36 (60%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 54 52 51
Total Primary Neoplasms 123 127 124 122
Total Animals with Benign Neoplasms 47 46 46 43
Total Benign Neoplasms 94 78 75 71
Total Animals with Malignant Neoplasms 22 42 35 43
Total Malignant Neoplasms 28 48 49 50
Total Animals with Metastatic Neoplasms 3 3 8 3
Total Metastatic Neoplasm 7 4 9 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 6 4 1 1
Moribund Sacrifice 27 34 32 48
Survivors
Terminal Sacrifice 17 12 17 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (60) (60)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (60) (60) (60) (60)
Intestine Small, Duodenum (60) (60) (60) (60)
Intestine Small, Jejunum (58) (57) (59) (60)
Intestine Small, Ileum (59) (59) (60) (60)
Liver (60) (60) (60) (60)
Hepatocellular Carcinoma 1 (2%) 1 (2%) 10 (17%) 4 (7%)
Hepatocellular Adenoma 2 (3%) 3 (5%) 6 (10%) 4 (7%)
Hepatocellular Adenoma, Multiple 1 (2%) 3 (5%) 3 (5%) 1 (2%)
Hepatocholangioma 1 (2%)
Mesentery (17) (11) (20) (18)
Hepatocellular Carcinoma, Metastatic, Liver 1 (6%)
Pancreas (60) (60) (60) (60)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Acinus, Adenoma 2 (3%) 1 (2%) 1 (2%)
Pharynx (1)
Palate, Squamous Cell Carcinoma 1 (100%)
Salivary Glands (60) (60) (60) (60)
Stomach, Forestomach (60) (60) (60) (60)
Stomach, Glandular (60) (60) (60) (60)
Tongue (1) (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Schwannoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 2 (3%)
Adrenal Medulla (60) (60) (60) (60)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 2 (3%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 15 (25%) 8 (13%) 8 (13%) 6 (10%)
Bilateral, Pheochromocytoma Benign 4 (7%) 3 (5%) 1 (2%) 4 (7%)
Islets, Pancreatic (60) (60) (60) (60)
Adenoma 3 (5%) 1 (2%) 1 (2%) 2 (3%)
Carcinoma 1 (2%) 5 (8%) 1 (2%) 1 (2%)
Parathyroid Gland (60) (60) (60) (59)
Pituitary Gland (60) (58) (59) (59)
Pars Distalis, Adenoma 41 (68%) 40 (69%) 36 (61%) 27 (46%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Intermedia, Adenoma 2 (3%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Adenoma 7 (12%) 8 (13%) 5 (8%) 4 (7%)
C-Cell, Carcinoma 2 (3%) 1 (2%) 4 (7%) 1 (2%)
Follicular Cell, Adenoma 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Preputial Gland (60) (60) (60) (59)
Adenoma 1 (2%) 3 (5%) 5 (8%) 2 (3%)
Carcinoma 4 (7%) 3 (5%) 1 (2%) 4 (7%)
Bilateral, Carcinoma 1 (2%)
Prostate (60) (60) (60) (60)
Seminal Vesicle (60) (60) (60) (60)
Testes (60) (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 42 (70%) 42 (70%) 50 (83%) 51 (85%)
Interstitial Cell, Adenoma 6 (10%) 5 (8%) 8 (13%) 6 (10%)
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Page 9
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (11) (17) (16) (17)
Lymph Node, Bronchial (55) (60) (56) (57)
Lymph Node, Mandibular (60) (57) (59) (56)
Lymph Node, Mesenteric (60) (60) (60) (60)
Lymph Node, Mediastinal (59) (57) (58) (56)
Spleen (60) (60) (60) (60)
Thymus (56) (57) (57) (54)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (43) (45) (39)
Adenoma 1 (3%)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 2 (5%) 2 (5%) 2 (4%) 1 (3%)
Skin (59) (60) (60) (60)
Basosquamous Tumor Benign 2 (3%) 1 (2%)
Keratoacanthoma 3 (5%) 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 3 (5%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Meningioma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (60) (60) (60) (60)
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Nose (60) (60) (60) (60)
Trachea (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Bilateral, Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Adenoma 5 (8%) 3 (5%)
Renal Tubule, Carcinoma 1 (2%) 2 (3%) 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
Urinary Bladder (59) (60) (60) (60)
Transitional Epithelium, Papilloma 4 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 34 (57%) 43 (72%) 38 (63%) 32 (53%)
Mesothelioma Malignant 5 (8%) 1 (2%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05132-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:24:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 156 PPM 312 PPM 625 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 58 60 59
Total Primary Neoplasms 193 187 207 167
Total Animals with Benign Neoplasms 59 57 60 59
Total Benign Neoplasms 140 129 139 120
Total Animals with Malignant Neoplasms 41 46 49 39
Total Malignant Neoplasms 53 57 67 47
Total Animals with Metastatic Neoplasms 1 1 1 2
Total Metastatic Neoplasm 1 1 1 3
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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