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TDMS Study 05132-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 05                                                                                     TIME: 00:41:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 116-14-3        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 05                                                                                     TIME: 00:41:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 116-14-3        




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 05                                                                                     TIME: 00:41:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 116-14-3        




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF TETRAFLUOROETHYLENE

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Islets, Pancreatic            Carcinoma
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
                                            Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
                                            Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
              Testes                        Adenoma
              Urinary Bladder               Papilloma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 05                                                                                     TIME: 00:41:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 116-14-3        




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF TETRAFLUOROETHYLENE

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Clitoral/Preputial Gland      Adenoma
                                            Carcinoma or Adenoma
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma
                                            Carcinoma or Adenoma
              Liver                         Hemangiosarcoma
                                            Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Hemangiosarcoma
                                            Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   1
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         8.2%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          674          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372        (e)        P=0.189        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.514        (e)        P=0.157        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.508        (e)        P=0.230        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.596                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/60 (32%)  11/60 (18%)   9/60 (15%)  10/60 (17%) |  4/60 (7%)    1/60 (2%)    2/60 (3%)    5/60 (8%)  |
|ADJUSTED (b)           |  60.0%        44.2%        33.4%        52.8%      |  12.7%         3.2%         9.6%        20.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  6/17 (35%)   2/12 (17%)   4/17 (24%)   0/1 (0%)   |  2/28 (7%)    0/16 (0%)    1/15 (7%)    2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   588          594          576          481       |   698          618          653          610       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.282      P=0.280N     P=0.058N     P=0.083    |  P=0.136      P=0.347N     P=0.577N     P=0.239    |
|INCIDENTAL TUMOR       |  P=0.093N     P=0.093N     P=0.022N*    P=0.176N   |  P=0.223      P=0.200N     P=0.437N     P=0.491    |
|LOGISTIC REGRESSION    |  P=0.062N     P=0.090N     P=0.027N*    P=0.280N   |  P=0.171      P=0.267N     P=0.472N     P=0.317    |
|COCHRAN-ARMITAGE       |  P=0.044N*                                         |  P=0.274                                           |
|FISHER EXACT           |               P=0.070N     P=0.025N*    P=0.043N*  |               P=0.182N     P=0.340N     P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   2
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  10.4%         0.0%         3.6%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   715          ---          664          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.402N     P=0.310N     P=0.528N     P=0.786N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.309N     P=0.291N     P=0.588N     P=0.528N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.298N     P=0.300N     P=0.526N     P=0.636N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.189N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.500N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/60 (33%)  12/60 (20%)   9/60 (15%)  10/60 (17%) |  4/60 (7%)    1/60 (2%)    2/60 (3%)    5/60 (8%)  |
|ADJUSTED (b)           |  63.6%        49.8%        33.4%        52.8%      |  12.7%         3.2%         9.6%        20.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  7/17 (41%)   3/12 (25%)   4/17 (24%)   0/1 (0%)   |  2/28 (7%)    0/16 (0%)    1/15 (7%)    2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   588          594          576          481       |   698          618          653          610       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.331      P=0.305N     P=0.039N*    P=0.087    |  P=0.136      P=0.347N     P=0.577N     P=0.239    |
|INCIDENTAL TUMOR       |  P=0.074N     P=0.111N     P=0.014N*    P=0.169N   |  P=0.223      P=0.200N     P=0.437N     P=0.491    |
|LOGISTIC REGRESSION    |  P=0.048N*    P=0.141N     P=0.017N*    P=0.238N   |  P=0.171      P=0.267N     P=0.472N     P=0.317    |
|COCHRAN-ARMITAGE       |  P=0.026N*                                         |  P=0.274                                           |
|FISHER EXACT           |               P=0.074N     P=0.016N*    P=0.028N*  |               P=0.182N     P=0.340N     P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   3
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    5/60 (8%)    2/59 (3%)  |  6/59 (10%)   7/59 (12%)   2/60 (3%)    0/58 (0%)  |
|ADJUSTED (b)           |   5.9%        25.0%        15.6%         6.0%      |  18.7%        32.6%        11.9%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    3/12 (25%)   1/17 (6%)    0/1 (0%)   |  4/28 (14%)   4/16 (25%)   1/15 (7%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      538          523       |   648          454 (I)      733          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.099      P=0.182      P=0.104      P=0.228    |  P=0.025N*    P=0.183      P=0.365N     P=0.062N   |
|INCIDENTAL TUMOR       |  P=0.314      P=0.182      P=0.112      P=0.480    |  P=0.017N*    P=0.260      P=0.239N     P=0.071N   |
|LOGISTIC REGRESSION    |  P=0.324      P=0.182      P=0.104      P=0.462    |  P=0.014N*    P=0.322      P=0.247N     P=0.048N*  |
|COCHRAN-ARMITAGE       |  P=0.430                                           |  P=0.005N**                                        |
|FISHER EXACT           |               P=0.309      P=0.103      P=0.494    |               P=0.500      P=0.131N     P=0.014N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    3/60 (5%)    2/60 (3%)    4/59 (7%)  |  1/59 (2%)    2/59 (3%)    2/60 (3%)    2/58 (3%)  |
|ADJUSTED (b)           |  17.1%        10.0%         4.9%        13.9%      |   3.6%         7.9%         8.3%         8.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   0/12 (0%)    0/17 (0%)    0/1 (0%)   |  1/28 (4%)    1/16 (6%)    0/15 (0%)    1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   453 (I)      494          538          481       |   734 (T)      454 (I)      625          610       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.271      P=0.603N     P=0.353N     P=0.190    |  P=0.308      P=0.372      P=0.350      P=0.356    |
|INCIDENTAL TUMOR       |  P=0.443N     P=0.506N     P=0.367N     P=0.639    |  P=0.387      P=0.372      P=0.537      P=0.523    |
|LOGISTIC REGRESSION    |  P=0.559      P=0.508N     P=0.338N     P=0.608    |  P=0.360      P=0.490      P=0.434      P=0.394    |
|COCHRAN-ARMITAGE       |  P=0.548                                           |  P=0.417                                           |
|FISHER EXACT           |               P=0.500N     P=0.340N     P=0.632    |               P=0.500      P=0.506      P=0.494    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   4
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    6/60 (10%)   6/60 (10%)   6/59 (10%) |  7/59 (12%)   9/59 (15%)   4/60 (7%)    2/58 (3%)  |
|ADJUSTED (b)           |  22.6%        32.5%        18.1%        19.0%      |  22.1%        39.3%        19.5%         8.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    2/10 (20%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/17 (18%)   3/12 (25%)   1/17 (6%)    0/1 (0%)   |  5/28 (18%)   5/16 (31%)   1/15 (7%)    1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   453 (I)      494          538          481       |   648          454 (I)      625          610       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.072      P=0.330      P=0.476      P=0.067    |  P=0.115N     P=0.104      P=0.594N     P=0.243N   |
|INCIDENTAL TUMOR       |  P=0.473      P=0.407      P=0.537      P=0.463    |  P=0.074N     P=0.153      P=0.369N     P=0.186N   |
|LOGISTIC REGRESSION    |  P=0.379      P=0.440      P=0.498      P=0.444    |  P=0.069N     P=0.243      P=0.427N     P=0.196N   |
|COCHRAN-ARMITAGE       |  P=0.443                                           |  P=0.030N*                                         |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.488    |               P=0.394      P=0.255N     P=0.085N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    1/59 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  15.3%         5.6%         5.9%        20.5%      |   0.0%         0.0%         6.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   0/12 (0%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    1/15 (7%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   705          705          733 (T)      626       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.248      P=0.433N     P=0.324N     P=0.182    |  P=0.635        (e)        P=0.376        (e)      |
|INCIDENTAL TUMOR       |  P=0.513      P=0.390N     P=0.338N     P=0.579    |  P=0.635        (e)        P=0.376        (e)      |
|LOGISTIC REGRESSION    |  P=0.455      P=0.401N     P=0.339N     P=0.507    |  P=0.635        (e)        P=0.376        (e)      |
|COCHRAN-ARMITAGE       |  P=0.475N                                          |  P=0.694                                           |
|FISHER EXACT           |               P=0.309N     P=0.309N     P=0.500N   |                 (e)        P=0.496        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   5
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    5/60 (8%)    1/60 (2%)    1/60 (2%)  |  0/60 (0%)    1/60 (2%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   3.4%        31.5%         5.9%         3.0%      |   0.0%         3.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    3/12 (25%)   1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   690          664          733 (T)      593       |   ---          653          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.432      P=0.049 *    P=0.730      P=0.587    |  P=0.632N     P=0.409        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.595N     P=0.058      P=0.719      P=0.700N   |  P=0.680N     P=0.438        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.566N     P=0.058      P=0.743      P=0.730    |  P=0.586N     P=0.486        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.313N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.103      P=0.752N     P=0.752N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    6/60 (10%)   2/60 (3%)    3/60 (5%)  |  0/60 (0%)    1/60 (2%)    1/59 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  18.2%        35.3%        11.8%        22.9%      |   0.0%         3.8%         6.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   3/12 (25%)   2/17 (12%)   0/1 (0%)   |  0/28 (0%)    0/16 (0%)    1/15 (7%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   690          664          733 (T)      593       |   ---          653          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.202      P=0.192      P=0.375N     P=0.144    |  P=0.674N     P=0.409      P=0.376        (e)      |
|INCIDENTAL TUMOR       |  P=0.524      P=0.232      P=0.395N     P=0.621    |  P=0.682      P=0.438      P=0.376        (e)      |
|LOGISTIC REGRESSION    |  P=0.508      P=0.227      P=0.387N     P=0.510    |  P=0.654N     P=0.486      P=0.376        (e)      |
|COCHRAN-ARMITAGE       |  P=0.279N                                          |  P=0.595N                                          |
|FISHER EXACT           |               P=0.372      P=0.340N     P=0.500N   |               P=0.500      P=0.496        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   6
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    6/60 (10%)   3/60 (5%)  |  0/60 (0%)    3/60 (5%)    1/60 (2%)    4/60 (7%)  |
|ADJUSTED (b)           |   0.0%         0.0%        25.7%        18.4%      |   0.0%        13.7%         3.3%        18.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    3/17 (18%)   0/1 (0%)   |  0/28 (0%)    1/16 (6%)    0/15 (0%)    3/18 (17%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          627          617       |   ---          574          668          454 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **     (e)        P=0.015 *    P=0.032 *  |  P=0.039 *    P=0.066      P=0.443      P=0.029 *  |
|INCIDENTAL TUMOR       |  P=0.017 *      (e)        P=0.016 *    P=0.223    |  P=0.038 *    P=0.126      P=0.536      P=0.029 *  |
|LOGISTIC REGRESSION    |  P=0.011 *      (e)        P=0.015 *    P=0.076    |  P=0.046 *    P=0.088      P=0.481      P=0.041 *  |
|COCHRAN-ARMITAGE       |  P=0.048 *                                         |  P=0.072                                           |
|FISHER EXACT           |                 (e)        P=0.014 *    P=0.122    |               P=0.122      P=0.500      P=0.059    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   2.8%         0.0%         9.2%         1.7%      |   0.0%         0.0%         0.0%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   649          ---          664          453 (I)   |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.264      P=0.543N     P=0.457      P=0.662    |  P=0.035 *      (e)          (e)        P=0.147    |
|INCIDENTAL TUMOR       |  P=0.339      P=0.522N     P=0.412      P=0.719    |  P=0.035 *      (e)          (e)        P=0.147    |
|LOGISTIC REGRESSION    |  P=0.487      P=0.509N     P=0.488      P=0.731N   |  P=0.035 *      (e)          (e)        P=0.147    |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.046 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.752N   |                 (e)          (e)        P=0.248    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   7
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    6/60 (10%)   4/60 (7%)  |  0/60 (0%)    3/60 (5%)    1/60 (2%)    6/60 (10%) |
|ADJUSTED (b)           |   2.8%         0.0%        25.7%        19.8%      |   0.0%        13.7%         3.3%        29.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    3/17 (18%)   0/1 (0%)   |  0/28 (0%)    1/16 (6%)    0/15 (0%)    5/18 (28%) |
|FIRST INCIDENCE (DAYS) |   649          ---          627          453 (I)   |   ---          574          668          454 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001 **   P=0.543N     P=0.049 *    P=0.051    |  P=0.004 **   P=0.066      P=0.443      P=0.004 ** |
|INCIDENTAL TUMOR       |  P=0.021 *    P=0.522N     P=0.047 *    P=0.254    |  P=0.004 **   P=0.126      P=0.536      P=0.004 ** |
|LOGISTIC REGRESSION    |  P=0.025 *    P=0.509N     P=0.052      P=0.174    |  P=0.004 **   P=0.088      P=0.481      P=0.006 ** |
|COCHRAN-ARMITAGE       |  P=0.053                                           |  P=0.011 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.057      P=0.182    |               P=0.122      P=0.500      P=0.014 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    5/60 (8%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%        19.5%         5.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          589          703       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.143        (e)        P=0.013 *    P=0.400    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.106        (e)        P=0.059      P=0.318    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.171        (e)        P=0.021 *    P=0.428    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.242                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)        P=0.029 *    P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   8
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    6/60 (10%)   9/60 (15%)   5/60 (8%)  |  0/60 (0%)    4/60 (7%)    5/60 (8%)    6/60 (10%) |
|ADJUSTED (b)           |  14.1%        32.0%        44.0%       100.0%      |   0.0%        22.6%        33.3%        28.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   3/12 (25%)   7/17 (41%)   1/1 (100%) |  0/28 (0%)    3/16 (19%)   5/15 (33%)   3/18 (17%) |
|FIRST INCIDENCE (DAYS) |   632          600          453 (I)      572       |   ---          707          734 (T)      677       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005 **   P=0.127      P=0.051      P=0.018 *  |  P=0.006 **   P=0.017 *    P=0.003 **   P=0.003 ** |
|INCIDENTAL TUMOR       |  P=0.067      P=0.208      P=0.080      P=0.185    |  P=0.003 **   P=0.018 *    P=0.003 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.114      P=0.180      P=0.049 *    P=0.184    |  P=0.004 **   P=0.020 *    P=0.003 **   P=0.003 ** |
|COCHRAN-ARMITAGE       |  P=0.342                                           |  P=0.026 *                                         |
|FISHER EXACT           |               P=0.245      P=0.063      P=0.359    |               P=0.059      P=0.029 *    P=0.014 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)   10/60 (17%)   4/60 (7%)  |  0/60 (0%)    4/60 (7%)    9/60 (15%)   2/60 (3%)  |
|ADJUSTED (b)           |   2.6%         3.4%        41.3%        20.2%      |   0.0%        20.9%        48.1%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    5/17 (29%)   0/1 (0%)   |  0/28 (0%)    3/16 (19%)   6/15 (40%)   2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   624          652          617          453 (I)   |   ---          583          668          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.710      P=0.005 **   P=0.062    |  P=0.146      P=0.020 *    P<0.001 **   P=0.147    |
|INCIDENTAL TUMOR       |  P=0.031 *    P=0.726N     P=0.007 **   P=0.367    |  P=0.143      P=0.038 *    P<0.001 **   P=0.147    |
|LOGISTIC REGRESSION    |  P=0.026 *    P=0.757      P=0.004 **   P=0.185    |  P=0.127      P=0.033 *    P<0.001 **   P=0.147    |
|COCHRAN-ARMITAGE       |  P=0.081                                           |  P=0.310                                           |
|FISHER EXACT           |               P=0.752N     P=0.004 **   P=0.182    |               P=0.059      P=0.001 **   P=0.248    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE   9
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    7/60 (12%)  16/60 (27%)   9/60 (15%) |  0/60 (0%)    7/60 (12%)  12/60 (20%)   8/60 (13%) |
|ADJUSTED (b)           |  16.3%        34.4%        62.7%       100.0%      |   0.0%        36.3%        65.4%        37.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   3/12 (25%)   9/17 (53%)   1/1 (100%) |  0/28 (0%)    5/16 (31%)   9/15 (60%)   5/18 (28%) |
|FIRST INCIDENCE (DAYS) |   624          600          453 (I)      453 (I)   |   ---          583          668          677       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.137      P=0.003 **   P=0.002 ** |  P=0.002 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.012 *    P=0.246      P=0.005 **   P=0.102    |  P=0.001 **   P=0.002 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.015 *    P=0.202      P=0.002 **   P=0.063    |  P=0.001 **   P=0.002 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.090                                           |  P=0.021 *                                         |
|FISHER EXACT           |               P=0.264      P=0.003 **   P=0.120    |               P=0.006 **   P<0.001 **   P=0.003 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    7/60 (12%)  16/60 (27%)   9/60 (15%) |  0/60 (0%)    7/60 (12%)  12/60 (20%)   8/60 (13%) |
|ADJUSTED (b)           |  16.3%        34.4%        62.7%       100.0%      |   0.0%        36.3%        65.4%        37.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   3/12 (25%)   9/17 (53%)   1/1 (100%) |  0/28 (0%)    5/16 (31%)   9/15 (60%)   5/18 (28%) |
|FIRST INCIDENCE (DAYS) |   624          600          453 (I)      453 (I)   |   ---          583          668          677       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.137      P=0.003 **   P=0.002 ** |  P=0.002 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.012 *    P=0.246      P=0.005 **   P=0.102    |  P=0.001 **   P=0.002 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.015 *    P=0.202      P=0.002 **   P=0.063    |  P=0.001 **   P=0.002 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.090                                           |  P=0.021 *                                         |
|FISHER EXACT           |               P=0.264      P=0.003 **   P=0.120    |               P=0.006 **   P<0.001 **   P=0.003 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  10
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         8.3%         8.4%         3.3%      |   0.0%         0.0%         6.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    1/12 (8%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    1/15 (7%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      621          604       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.128      P=0.431      P=0.234      P=0.448    |  P=0.635        (e)        P=0.376        (e)      |
|INCIDENTAL TUMOR       |  P=0.311      P=0.431      P=0.314      P=0.718    |  P=0.635        (e)        P=0.376        (e)      |
|LOGISTIC REGRESSION    |  P=0.259      P=0.431      P=0.231      P=0.502    |  P=0.635        (e)        P=0.376        (e)      |
|COCHRAN-ARMITAGE       |  P=0.367                                           |  P=0.694                                           |
|FISHER EXACT           |               P=0.500      P=0.248      P=0.500    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   1.7%         8.3%         8.4%         3.3%      |   0.0%         6.3%         6.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    1/12 (8%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    1/16 (6%)    1/15 (7%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   453 (I)      733 (T)      621          604       |   ---          734 (T)      734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.366      P=0.722      P=0.494      P=0.732    |  P=0.667N     P=0.388      P=0.376        (e)      |
|INCIDENTAL TUMOR       |  P=0.572      P=0.722      P=0.578      P=0.647N   |  P=0.667N     P=0.388      P=0.376        (e)      |
|LOGISTIC REGRESSION    |  P=0.572      P=0.756N     P=0.498      P=0.729N   |  P=0.667N     P=0.388      P=0.376        (e)      |
|COCHRAN-ARMITAGE       |  P=0.591                                           |  P=0.595N                                          |
|FISHER EXACT           |               P=0.752N     P=0.500      P=0.752N   |               P=0.500      P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  11
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |  3/60 (5%)    1/60 (2%)    4/60 (7%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         4.8%         2.8%         0.0%      |   8.9%         2.6%        18.6%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  1/28 (4%)    0/16 (0%)    2/15 (13%)   1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          698          627          ---       |   693          581          611          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.630      P=0.450      P=0.489        (e)      |  P=0.523N     P=0.461N     P=0.262      P=0.501N   |
|INCIDENTAL TUMOR       |  P=0.527N     P=0.478      P=0.638        (e)      |  P=0.445N     P=0.291N     P=0.452      P=0.563N   |
|LOGISTIC REGRESSION    |  P=0.657N     P=0.465      P=0.500        (e)      |  P=0.455N     P=0.362N     P=0.391      P=0.467N   |
|COCHRAN-ARMITAGE       |  P=0.595N                                          |  P=0.344N                                          |
|FISHER EXACT           |               P=0.500      P=0.500        (e)      |               P=0.309N     P=0.500      P=0.309N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    1/60 (2%)    1/60 (2%)  |  4/60 (7%)    1/60 (2%)    5/60 (8%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         4.8%         2.8%         2.2%      |  12.2%         2.6%        22.5%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  2/28 (7%)    0/16 (0%)    2/15 (13%)   2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   ---          698          627          523       |   693          581          611          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.232      P=0.450      P=0.489      P=0.496    |  P=0.522      P=0.336N     P=0.226      P=0.575N   |
|INCIDENTAL TUMOR       |  P=0.494      P=0.478      P=0.638      P=0.638    |  P=0.577N     P=0.200N     P=0.427      P=0.626N   |
|LOGISTIC REGRESSION    |  P=0.381      P=0.465      P=0.500      P=0.530    |  P=0.577N     P=0.244N     P=0.362      P=0.567N   |
|COCHRAN-ARMITAGE       |  P=0.385                                           |  P=0.421N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500    |               P=0.182N     P=0.500      P=0.340N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  12
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  | 22/60 (37%)  11/60 (18%)   9/60 (15%)   8/60 (13%) |
|ADJUSTED (b)           |  10.4%        12.7%        11.8%         9.1%      |  55.2%        41.8%        38.1%        29.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  1/17 (6%)    1/12 (8%)    2/17 (12%)   0/1 (0%)   | 11/28 (39%)   5/16 (31%)   4/15 (27%)   3/18 (17%) |
|FIRST INCIDENCE (DAYS) |   715          698          733 (T)      668       |   481          468          534          454 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.326      P=0.580      P=0.691      P=0.453    |  P=0.057N     P=0.277N     P=0.162N     P=0.086N   |
|INCIDENTAL TUMOR       |  P=0.481      P=0.610      P=0.662      P=0.695    |  P=0.008N**   P=0.047N*    P=0.009N**   P=0.034N*  |
|LOGISTIC REGRESSION    |  P=0.491      P=0.598      P=0.670      P=0.681    |  P=0.011N*    P=0.058N     P=0.019N*    P=0.015N*  |
|COCHRAN-ARMITAGE       |  P=0.373N                                          |  P=0.003N**                                        |
|FISHER EXACT           |               P=0.691N     P=0.691N     P=0.500N   |               P=0.020N*    P=0.006N**   P=0.003N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    2/60 (3%)    2/60 (3%)  | 23/60 (38%)  11/60 (18%)  10/60 (17%)   9/60 (15%) |
|ADJUSTED (b)           |  10.4%        12.7%        11.8%        11.1%      |  57.8%        41.8%        41.1%        34.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  1/17 (6%)    1/12 (8%)    2/17 (12%)   0/1 (0%)   | 12/28 (43%)   5/16 (31%)   4/15 (27%)   4/18 (22%) |
|FIRST INCIDENCE (DAYS) |   715          698          733 (T)      523       |   481          468          534          454 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.130      P=0.580      P=0.691      P=0.229    |  P=0.080N     P=0.232N     P=0.196N     P=0.103N   |
|INCIDENTAL TUMOR       |  P=0.279      P=0.610      P=0.662      P=0.516    |  P=0.014N*    P=0.034N*    P=0.011N*    P=0.046N*  |
|LOGISTIC REGRESSION    |  P=0.358      P=0.598      P=0.670      P=0.575    |  P=0.018N*    P=0.041N*    P=0.023N*    P=0.021N*  |
|COCHRAN-ARMITAGE       |  P=0.596                                           |  P=0.005N**                                        |
|FISHER EXACT           |               P=0.691N     P=0.691N     P=0.691N   |               P=0.013N*    P=0.007N**   P=0.003N** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  13
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    3/60 (5%)    2/60 (3%)  | 24/60 (40%)  12/60 (20%)  13/60 (22%)   9/60 (15%) |
|ADJUSTED (b)           |  10.4%        12.7%        14.2%        11.1%      |  59.0%        43.3%        49.8%        34.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  1/17 (6%)    1/12 (8%)    2/17 (12%)   0/1 (0%)   | 12/28 (43%)   5/16 (31%)   5/15 (33%)   4/18 (22%) |
|FIRST INCIDENCE (DAYS) |   715          698          627          523       |   481          468          534          454 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.117      P=0.580      P=0.491      P=0.229    |  P=0.079N     P=0.260N     P=0.386N     P=0.084N   |
|INCIDENTAL TUMOR       |  P=0.325      P=0.610      P=0.527      P=0.516    |  P=0.010N*    P=0.029N*    P=0.034N*    P=0.034N*  |
|LOGISTIC REGRESSION    |  P=0.353      P=0.598      P=0.461      P=0.575    |  P=0.015N*    P=0.044N*    P=0.070N     P=0.014N*  |
|COCHRAN-ARMITAGE       |  P=0.569                                           |  P=0.003N**                                        |
|FISHER EXACT           |               P=0.691N     P=0.500      P=0.691N   |               P=0.014N*    P=0.024N*    P=0.002N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.9%         8.3%         0.0%         0.0%      |   6.8%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    1/12 (8%)    0/17 (0%)    0/1 (0%)   |  1/28 (4%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      ---          ---       |   721          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.463N     P=0.684      P=0.500N     P=0.974N   |  P=0.169N     P=0.350N     P=0.364N     P=0.343N   |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.684      P=0.500N     P=0.974N   |  P=0.163N     P=0.339N     P=0.284N     P=0.395N   |
|LOGISTIC REGRESSION    |  P=0.463N     P=0.684      P=0.500N     P=0.974N   |  P=0.165N     P=0.338N     P=0.328N     P=0.353N   |
|COCHRAN-ARMITAGE       |  P=0.236N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.752N     P=0.500N     P=0.500N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  14
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   9.2%         8.3%         0.0%         0.0%      |   6.8%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    1/12 (8%)    0/17 (0%)    0/1 (0%)   |  1/28 (4%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   691          733 (T)      ---          ---       |   721          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.230N     P=0.608N     P=0.266N     P=0.702N   |  P=0.169N     P=0.350N     P=0.364N     P=0.343N   |
|INCIDENTAL TUMOR       |  P=0.201N     P=0.593N     P=0.281N     P=0.528N   |  P=0.163N     P=0.339N     P=0.284N     P=0.395N   |
|LOGISTIC REGRESSION    |  P=0.191N     P=0.592N     P=0.257N     P=0.517N   |  P=0.165N     P=0.338N     P=0.328N     P=0.353N   |
|COCHRAN-ARMITAGE       |  P=0.101N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.500N     P=0.248N     P=0.248N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%        12.7%         5.9%         5.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    1/12 (8%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          698          733 (T)      630       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.150      P=0.177      P=0.500      P=0.372    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.341      P=0.191      P=0.500      P=0.718    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.299      P=0.183      P=0.500      P=0.476    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.500                                           |    (e)                                             |
|FISHER EXACT           |               P=0.248      P=0.500      P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  15
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 42/60 (70%)  40/58 (69%)  36/59 (61%)  27/59 (46%) | 44/60 (73%)  36/60 (60%)  37/59 (63%)  34/60 (57%) |
|ADJUSTED (b)           |  95.1%        91.5%        84.7%        87.0%      |  93.5%        88.7%        94.1%        88.9%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   3/9 (33%)    1/10 (10%)   4/10 (40%) |  1/10 (10%)   2/10 (20%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 15/17 (88%)   9/12 (75%)  10/16 (63%)   0/0        | 25/28 (89%)  12/16 (75%)  13/15 (87%)  14/18 (78%) |
|FIRST INCIDENCE (DAYS) |   336          351          453 (I)      361       |   454 (I)      413          387          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039 *    P=0.209      P=0.410N     P=0.003 ** |  P=0.242      P=0.129      P=0.078      P=0.209    |
|INCIDENTAL TUMOR       |  P=0.011N*    P=0.582N     P=0.263N     P=0.125N   |  P=0.181N     P=0.213N     P=0.342N     P=0.204N   |
|LOGISTIC REGRESSION    |  P=0.012N*    P=0.573      P=0.179N     P=0.035N*  |  P=0.256N     P=0.323N     P=0.434N     P=0.198N   |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.061N                                          |
|FISHER EXACT           |               P=0.531N     P=0.201N     P=0.006N** |               P=0.087N     P=0.148N     P=0.042N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 42/60 (70%)  40/58 (69%)  36/59 (61%)  27/59 (46%) | 44/60 (73%)  37/60 (62%)  37/59 (63%)  34/60 (57%) |
|ADJUSTED (b)           |  95.1%        91.5%        84.7%        87.0%      |  93.5%        91.6%        94.1%        88.9%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   3/9 (33%)    1/10 (10%)   4/10 (40%) |  1/10 (10%)   2/10 (20%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 15/17 (88%)   9/12 (75%)  10/16 (63%)   0/0        | 25/28 (89%)  13/16 (81%)  13/15 (87%)  14/18 (78%) |
|FIRST INCIDENCE (DAYS) |   336          351          453 (I)      361       |   454 (I)      413          387          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039 *    P=0.209      P=0.410N     P=0.003 ** |  P=0.253      P=0.093      P=0.078      P=0.209    |
|INCIDENTAL TUMOR       |  P=0.011N*    P=0.582N     P=0.263N     P=0.125N   |  P=0.164N     P=0.310N     P=0.342N     P=0.204N   |
|LOGISTIC REGRESSION    |  P=0.012N*    P=0.573      P=0.179N     P=0.035N*  |  P=0.304N     P=0.416N     P=0.434N     P=0.198N   |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.053N                                          |
|FISHER EXACT           |               P=0.531N     P=0.201N     P=0.006N** |               P=0.121N     P=0.148N     P=0.042N*  |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  16
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/58 (0%)    0/59 (0%)    0/59 (0%)  |  0/60 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/9 (0%)     0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/16 (0%)    0/0        |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   453 (I)      ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.151N     P=0.281N     P=0.269N     P=0.362N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.135N     P=0.264N     P=0.281N     P=0.281N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.108N     P=0.238N     P=0.246N     P=0.214N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.117N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.256N     P=0.252N     P=0.252N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  10.8%         0.0%         0.0%         3.8%      |   0.0%         0.0%         4.8%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   721          ---          ---          617       |   ---          ---          702          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.658      P=0.323N     P=0.234N     P=0.557    |  P=0.177        (e)        P=0.404      P=0.412    |
|INCIDENTAL TUMOR       |  P=0.515N     P=0.291N     P=0.281N     P=0.661N   |  P=0.151        (e)        P=0.536      P=0.412    |
|LOGISTIC REGRESSION    |  P=0.604N     P=0.303N     P=0.256N     P=0.755    |  P=0.173        (e)        P=0.454      P=0.412    |
|COCHRAN-ARMITAGE       |  P=0.462N                                          |  P=0.236                                           |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.500N   |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  17
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)   0/60 (0%)    2/60 (3%)    3/60 (5%)  |  2/60 (3%)    0/60 (0%)    2/60 (3%)    3/60 (5%)  |
|ADJUSTED (b)           |  32.3%         0.0%         7.7%        12.6%      |   7.1%         0.0%        11.1%        16.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/17 (18%)   0/12 (0%)    0/17 (0%)    0/1 (0%)   |  2/28 (7%)    0/16 (0%)    1/15 (7%)    3/18 (17%) |
|FIRST INCIDENCE (DAYS) |   686          ---          575          617       |   734 (T)      ---          702          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.527      P=0.029N*    P=0.092N     P=0.301    |  P=0.136      P=0.368N     P=0.470      P=0.301    |
|INCIDENTAL TUMOR       |  P=0.247N     P=0.018N*    P=0.114N     P=0.331N   |  P=0.128      P=0.368N     P=0.539      P=0.301    |
|LOGISTIC REGRESSION    |  P=0.407N     P=0.019N*    P=0.097N     P=0.560N   |  P=0.120      P=0.368N     P=0.550      P=0.301    |
|COCHRAN-ARMITAGE       |  P=0.212N                                          |  P=0.238                                           |
|FISHER EXACT           |               P=0.006N**   P=0.081N     P=0.161N   |               P=0.248N     P=0.691N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basosquamous Tumor Benign                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  10.8%         0.0%         0.0%         3.8%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   721          ---          ---          617       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.658      P=0.323N     P=0.234N     P=0.557    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.515N     P=0.291N     P=0.281N     P=0.661N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.604N     P=0.303N     P=0.256N     P=0.755    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.462N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  18
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.3%         5.6%         0.0%         2.6%      |   0.0%         6.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    1/16 (6%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   635          705          ---          571       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.430N     P=0.420N     P=0.150N     P=0.700N   |  P=0.619N     P=0.388        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.184N     P=0.317N     P=0.102N     P=0.285N   |  P=0.619N     P=0.388        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.256N     P=0.354N     P=0.126N     P=0.405N   |  P=0.619N     P=0.388        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.201N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.309N     P=0.122N     P=0.309N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    2/60 (3%)    3/60 (5%)  |  1/60 (2%)    2/60 (3%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.3%         5.6%         5.2%        23.8%      |   2.4%         8.5%         1.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    1/16 (6%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   635          705          453 (I)      525       |   663          565          387          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.171      P=0.420N     P=0.556N     P=0.225    |  P=0.318N     P=0.370      P=0.728      P=0.615N   |
|INCIDENTAL TUMOR       |  P=0.471      P=0.317N     P=0.508N     P=0.671N   |  P=0.199N     P=0.543      P=0.633N     P=0.682N   |
|LOGISTIC REGRESSION    |  P=0.446      P=0.354N     P=0.500N     P=0.580    |  P=0.219N     P=0.474      P=0.707N     P=0.533N   |
|COCHRAN-ARMITAGE       |  P=0.477                                           |  P=0.248N                                          |
|FISHER EXACT           |               P=0.309N     P=0.500N     P=0.660N   |               P=0.500      P=0.752N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  19
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    2/60 (3%)  |  1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.2%        21.8%      |   2.4%         2.4%         1.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          453 (I)      525       |   663          565          387          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.028 *      (e)        P=0.218      P=0.085    |  P=0.366N     P=0.695      P=0.728      P=0.615N   |
|INCIDENTAL TUMOR       |  P=0.087        (e)        P=0.198      P=0.265    |  P=0.217N     P=0.668N     P=0.633N     P=0.682N   |
|LOGISTIC REGRESSION    |  P=0.098        (e)        P=0.226      P=0.224    |  P=0.241N     P=0.753N     P=0.707N     P=0.533N   |
|COCHRAN-ARMITAGE       |  P=0.087                                           |  P=0.312N                                          |
|FISHER EXACT           |                 (e)        P=0.248      P=0.248    |               P=0.752N     P=0.752N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  14.7%         0.0%         2.2%         5.3%      |   7.1%         0.0%         0.0%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   0/12 (0%)    0/17 (0%)    0/1 (0%)   |  2/28 (7%)    0/16 (0%)    0/15 (0%)    1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   686          ---          575          632       |   734 (T)      ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.579N     P=0.184N     P=0.326N     P=0.598    |  P=0.561N     P=0.368N     P=0.383N     P=0.653N   |
|INCIDENTAL TUMOR       |  P=0.325N     P=0.172N     P=0.278N     P=0.626N   |  P=0.561N     P=0.368N     P=0.383N     P=0.653N   |
|LOGISTIC REGRESSION    |  P=0.390N     P=0.166N     P=0.316N     P=0.622N   |  P=0.561N     P=0.368N     P=0.383N     P=0.653N   |
|COCHRAN-ARMITAGE       |  P=0.297N                                          |  P=0.461N                                          |
|FISHER EXACT           |               P=0.122N     P=0.309N     P=0.309N   |               P=0.248N     P=0.248N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  20
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign, malignant or NOS)                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   3.0%         0.0%         8.7%         0.0%      |   0.0%         0.0%         0.0%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   674          ---          632          ---       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.643      P=0.564N     P=0.460      P=0.737N   |  P=0.171        (e)          (e)        P=0.412    |
|INCIDENTAL TUMOR       |  P=0.514N     P=0.522N     P=0.534      P=0.576N   |  P=0.171        (e)          (e)        P=0.412    |
|LOGISTIC REGRESSION    |  P=0.571N     P=0.520N     P=0.489      P=0.605N   |  P=0.171        (e)          (e)        P=0.412    |
|COCHRAN-ARMITAGE       |  P=0.461N                                          |  P=0.198                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    0/60 (0%)    2/60 (3%)    2/60 (3%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |  23.5%         0.0%         7.7%         8.9%      |   7.1%         0.0%         6.7%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   0/12 (0%)    0/17 (0%)    0/1 (0%)   |  2/28 (7%)    0/16 (0%)    1/15 (7%)    2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   686          ---          575          617       |   734 (T)      ---          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.552      P=0.071N     P=0.233N     P=0.421    |  P=0.345      P=0.368N     P=0.713N     P=0.528    |
|INCIDENTAL TUMOR       |  P=0.291N     P=0.054N     P=0.264N     P=0.379N   |  P=0.345      P=0.368N     P=0.713N     P=0.528    |
|LOGISTIC REGRESSION    |  P=0.437N     P=0.056N     P=0.241N     P=0.575N   |  P=0.345      P=0.368N     P=0.713N     P=0.528    |
|COCHRAN-ARMITAGE       |  P=0.264N                                          |  P=0.469                                           |
|FISHER EXACT           |               P=0.029N*    P=0.219N     P=0.219N   |               P=0.248N     P=0.500N     P=0.691N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  21
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |  19.0%         0.0%         2.2%         8.9%      |   7.1%         0.0%         6.7%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   0/12 (0%)    0/17 (0%)    0/1 (0%)   |  2/28 (7%)    0/16 (0%)    1/15 (7%)    2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   686          ---          575          617       |   734 (T)      ---          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.525      P=0.112N     P=0.197N     P=0.375    |  P=0.345      P=0.368N     P=0.713N     P=0.528    |
|INCIDENTAL TUMOR       |  P=0.371N     P=0.096N     P=0.183N     P=0.532N   |  P=0.345      P=0.368N     P=0.713N     P=0.528    |
|LOGISTIC REGRESSION    |  P=0.498N     P=0.096N     P=0.192N     P=0.657N   |  P=0.345      P=0.368N     P=0.713N     P=0.528    |
|COCHRAN-ARMITAGE       |  P=0.374N                                          |  P=0.469                                           |
|FISHER EXACT           |               P=0.059N     P=0.182N     P=0.340N   |               P=0.248N     P=0.500N     P=0.691N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/60 (80%)  47/60 (78%)  58/60 (97%)  57/60 (95%) |                                                    |
|ADJUSTED (b)           |  93.6%        97.6%       100.0%       100.0%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  9/10 (90%)   7/10 (70%)  10/10 (100%) 10/10 (100%)|                                                    |
|TERMINAL (d)           | 14/17 (82%)  11/12 (92%)  17/17 (100%)  1/1 (100%) |                                                    |
|FIRST INCIDENCE (DAYS) |   453 (I)      453 (I)      413          453 (I)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.163      P=0.064      P<0.001 ** |                                                    |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.579N     P=0.007 **   P=0.006 ** |                                                    |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.563N     P=0.005 **   P=0.006 ** |                                                    |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |                                                    |
|FISHER EXACT           |               P=0.500N     P=0.004 **   P=0.012 *  |                                                    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  22
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)   8/60 (13%)   5/60 (8%)    4/60 (7%)  |  5/60 (8%)    9/60 (15%)   5/60 (8%)    2/60 (3%)  |
|ADJUSTED (b)           |  31.8%        37.3%        21.6%        20.6%      |  16.7%        35.0%        22.7%         8.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/17 (18%)   3/12 (25%)   2/17 (12%)   0/1 (0%)   |  4/28 (14%)   1/16 (6%)    2/15 (13%)   1/18 (6%)  |
|FIRST INCIDENCE (DAYS) |   707          533          631          571       |   698          523          587          579       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.283      P=0.286      P=0.437N     P=0.128    |  P=0.265N     P=0.044 *    P=0.316      P=0.420N   |
|INCIDENTAL TUMOR       |  P=0.338N     P=0.388      P=0.474N     P=0.516N   |  P=0.175N     P=0.086      P=0.472      P=0.334N   |
|LOGISTIC REGRESSION    |  P=0.405N     P=0.368      P=0.441N     P=0.594    |  P=0.189N     P=0.072      P=0.465      P=0.388N   |
|COCHRAN-ARMITAGE       |  P=0.154N                                          |  P=0.088N                                          |
|FISHER EXACT           |               P=0.500      P=0.381N     P=0.264N   |               P=0.197      P=0.628N     P=0.219N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    4/60 (7%)    1/60 (2%)  |  2/60 (3%)    2/60 (3%)    3/60 (5%)    2/60 (3%)  |
|ADJUSTED (b)           |  11.8%         8.3%        18.4%         3.8%      |   7.1%         8.2%        20.0%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/17 (12%)   1/12 (8%)    2/17 (12%)   0/1 (0%)   |  2/28 (7%)    1/16 (6%)    3/15 (20%)   2/18 (11%) |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      658          617       |   734 (T)      468          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.204      P=0.623N     P=0.307      P=0.508    |  P=0.406      P=0.536      P=0.228      P=0.528    |
|INCIDENTAL TUMOR       |  P=0.346      P=0.623N     P=0.279      P=0.750    |  P=0.465      P=0.608      P=0.228      P=0.528    |
|LOGISTIC REGRESSION    |  P=0.393      P=0.623N     P=0.290      P=0.739    |  P=0.417      P=0.652      P=0.228      P=0.528    |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.568                                           |
|FISHER EXACT           |               P=0.500N     P=0.340      P=0.500N   |               P=0.691N     P=0.500      P=0.691N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  23
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)   9/60 (15%)   9/60 (15%)   5/60 (8%)  |  7/60 (12%)  11/60 (18%)   7/60 (12%)   4/60 (7%)  |
|ADJUSTED (b)           |  36.7%        44.3%        37.2%        23.7%      |  23.6%        40.6%        34.6%        19.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/17 (24%)   4/12 (33%)   4/17 (24%)   0/1 (0%)   |  6/28 (21%)   2/16 (13%)   4/15 (27%)   3/18 (17%) |
|FIRST INCIDENCE (DAYS) |   707          533          631          571       |   698          468          587          579       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.105      P=0.263      P=0.433      P=0.073    |  P=0.365N     P=0.041 *    P=0.215      P=0.548N   |
|INCIDENTAL TUMOR       |  P=0.548N     P=0.357      P=0.374      P=0.571N   |  P=0.252N     P=0.088      P=0.333      P=0.477N   |
|LOGISTIC REGRESSION    |  P=0.532      P=0.343      P=0.416      P=0.527    |  P=0.281N     P=0.086      P=0.375      P=0.551N   |
|COCHRAN-ARMITAGE       |  P=0.208N                                          |  P=0.121N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.279N   |               P=0.222      P=0.611N     P=0.264N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.2%         0.0%         3.6%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   453 (I)      ---          664          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.298N     P=0.268N     P=0.533N     P=0.401N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.236N     P=0.252N     P=0.588N     P=0.281N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.184N     P=0.228N     P=0.501N     P=0.216N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.189N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.500N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  24
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.2%         0.0%         3.6%         0.0%      |   0.0%         6.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    1/16 (6%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   453 (I)      ---          664          ---       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.298N     P=0.268N     P=0.533N     P=0.401N   |  P=0.619N     P=0.388        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.236N     P=0.252N     P=0.588N     P=0.281N   |  P=0.619N     P=0.388        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.184N     P=0.228N     P=0.501N     P=0.216N   |  P=0.619N     P=0.388        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.189N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.248N     P=0.500N     P=0.248N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.9%         8.3%         0.0%         0.0%      |   6.8%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    1/12 (8%)    0/17 (0%)    0/1 (0%)   |  1/28 (4%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      ---          ---       |   721          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.463N     P=0.684      P=0.500N     P=0.974N   |  P=0.169N     P=0.350N     P=0.364N     P=0.343N   |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.684      P=0.500N     P=0.974N   |  P=0.163N     P=0.339N     P=0.284N     P=0.395N   |
|LOGISTIC REGRESSION    |  P=0.463N     P=0.684      P=0.500N     P=0.974N   |  P=0.165N     P=0.338N     P=0.328N     P=0.353N   |
|COCHRAN-ARMITAGE       |  P=0.236N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.752N     P=0.500N     P=0.500N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  25
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    4/60 (7%)    0/60 (0%)    0/60 (0%)  |  0/59 (0%)    0/60 (0%)    2/60 (3%)    0/59 (0%)  |
|ADJUSTED (b)           |   0.0%        16.3%         0.0%         0.0%      |   0.0%         0.0%        10.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    1/12 (8%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    1/15 (7%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          453 (I)      ---          ---       |   ---          ---          677          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.393N     P=0.046 *      (e)          (e)      |  P=0.499        (e)        P=0.134        (e)      |
|INCIDENTAL TUMOR       |  P=0.267N     P=0.066        (e)          (e)      |  P=0.485        (e)        P=0.196        (e)      |
|LOGISTIC REGRESSION    |  P=0.245N     P=0.066        (e)          (e)      |  P=0.524        (e)        P=0.185        (e)      |
|COCHRAN-ARMITAGE       |  P=0.244N                                          |  P=0.594                                           |
|FISHER EXACT           |               P=0.061        (e)          (e)      |                 (e)        P=0.252        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  6/60 (10%)   5/60 (8%)    6/60 (10%)   6/60 (10%) |
|ADJUSTED (b)           |                                                    |  19.7%        24.2%        23.9%        19.3%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    2/10 (20%)   1/10 (10%) |
|TERMINAL (d)           |                                                    |  5/28 (18%)   3/16 (19%)   2/15 (13%)   2/18 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   626          583          454 (I)      439       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.289      P=0.405      P=0.295      P=0.370    |
|INCIDENTAL TUMOR       |                                                    |  P=0.419      P=0.617      P=0.425      P=0.537N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.414      P=0.544      P=0.542      P=0.534    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.515                                           |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.619N     P=0.619N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  26
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  6/60 (10%)   6/60 (10%)   6/60 (10%)   7/60 (12%) |
|ADJUSTED (b)           |                                                    |  19.7%        26.9%        23.9%        21.9%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    2/10 (20%)   1/10 (10%) |
|TERMINAL (d)           |                                                    |  5/28 (18%)   3/16 (19%)   2/15 (13%)   2/18 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   626          583          454 (I)      439       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.212      P=0.270      P=0.295      P=0.253    |
|INCIDENTAL TUMOR       |                                                    |  P=0.377      P=0.562      P=0.425      P=0.592N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.334      P=0.421      P=0.542      P=0.417    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.429                                           |
|FISHER EXACT           |                                                    |               P=0.619N     P=0.619N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    5/60 (8%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.3%         0.0%      |   0.0%         0.0%        19.5%         5.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          576          ---       |   ---          ---          589          703       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.679        (e)        P=0.505        (e)      |  P=0.143        (e)        P=0.013 *    P=0.400    |
|INCIDENTAL TUMOR       |  P=0.675N       (e)        P=0.638        (e)      |  P=0.106        (e)        P=0.059      P=0.318    |
|LOGISTIC REGRESSION    |  P=0.706        (e)        P=0.495        (e)      |  P=0.171        (e)        P=0.021 *    P=0.428    |
|COCHRAN-ARMITAGE       |  P=0.695                                           |  P=0.242                                           |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |                 (e)        P=0.029 *    P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  27
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.2%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/17 (0%)    0/12 (0%)    0/17 (0%)    0/1 (0%)   |  1/28 (4%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   454 (I)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.143N     P=0.300N     P=0.307N     P=0.288N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.143N     P=0.300N     P=0.307N     P=0.288N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.104N     P=0.209N     P=0.212N     P=0.207N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.115N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 34/60 (57%)  43/60 (72%)  38/60 (63%)  32/60 (53%) | 16/60 (27%)  31/60 (52%)  23/60 (38%)  36/60 (60%) |
|ADJUSTED (b)           |  81.5%        95.3%        91.9%       100.0%      |  43.7%        76.5%        65.1%        82.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 10/17 (59%)  10/12 (83%)  14/17 (82%)   1/1 (100%) |  8/28 (29%)   7/16 (44%)   6/15 (40%)  11/18 (61%) |
|FIRST INCIDENCE (DAYS) |   509          351          413          453 (I)   |   621          468          469          372       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.016 *    P=0.231      P<0.001 ** |  P<0.001 **   P<0.001 **   P=0.008 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.167N     P=0.024 *    P=0.376      P=0.307N   |  P<0.001 **   P=0.003 **   P=0.136      P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.144N     P=0.029 *    P=0.391      P=0.130N   |  P<0.001 **   P=0.002 **   P=0.105      P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.203N                                          |  P=0.001 **                                        |
|FISHER EXACT           |               P=0.064      P=0.288      P=0.427N   |               P=0.004 **   P=0.121      P<0.001 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  28
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    1/60 (2%)    2/60 (3%)    2/60 (3%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  15.0%         3.8%         9.5%         3.9%      |   0.0%         1.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/17 (6%)    0/12 (0%)    1/17 (6%)    0/1 (0%)   |  0/28 (0%)    0/16 (0%)    0/15 (0%)    0/18 (0%)  |
|FIRST INCIDENCE (DAYS) |   489          664          674          453 (I)   |   ---          413          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.464N     P=0.154N     P=0.253N     P=0.450N   |  P=0.574N     P=0.497        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.227N     P=0.080N     P=0.220N     P=0.129N   |  P=0.402N     P=0.638        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.220N     P=0.105N     P=0.219N     P=0.180N   |  P=0.417N     P=0.665        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.223N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.103N     P=0.219N     P=0.219N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 59/60 (98%)  57/60 (95%)  60/60 (100%) 59/60 (98%) | 47/60 (78%)  46/60 (77%)  46/60 (77%)  43/60 (72%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  95.8%        97.7%       100.0%        95.3%      |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%)  9/10 (90%)  10/10 (100%) 10/10 (100%)|  1/10 (10%)   3/10 (30%)   3/10 (30%)   3/10 (30%) |
|TERMINAL (d)           | 17/17 (100%) 12/12 (100%) 17/17 (100%)  1/1 (100%) | 26/28 (93%)  15/16 (94%)  15/15 (100%) 16/18 (89%) |
|FIRST INCIDENCE (DAYS) |   336          351          413          361       |   454 (I)      413          387          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.160      P=0.365      P<0.001 ** |  P=0.057      P=0.009 **   P=0.008 **   P=0.035 *  |
|INCIDENTAL TUMOR       |  P=0.321      P=0.367N     P=0.638      P=0.603    |  P=0.451N     P=0.491      P=0.418      P=0.528N   |
|LOGISTIC REGRESSION    |  P=0.378      P=0.321N     P=0.903      P=0.720N   |  P=0.415      P=0.278      P=0.326      P=0.377    |
|COCHRAN-ARMITAGE       |  P=0.410                                           |  P=0.222N                                          |
|FISHER EXACT           |               P=0.309N     P=0.500      P=0.752N   |               P=0.500N     P=0.500N     P=0.264N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  29
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      156 PPM      312 PPM      625 PPM   |   CONTROL      312 PPM      625 PPM      1250 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 41/60 (68%)  46/60 (77%)  49/60 (82%)  39/60 (65%) | 22/60 (37%)  42/60 (70%)  35/60 (58%)  43/60 (72%) |
|ADJUSTED (b)           |  88.3%        97.8%        98.0%       100.0%      |  53.4%        93.1%        83.9%        91.2%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   0/10 (0%)    1/10 (10%)   4/10 (40%) |  1/10 (10%)   1/10 (10%)   0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           | 12/17 (71%)  11/12 (92%)  16/17 (94%)   1/1 (100%) | 10/28 (36%)  13/16 (81%)   9/15 (60%)  14/18 (78%) |
|FIRST INCIDENCE (DAYS) |   453 (I)      351          413          453 (I)   |   433          413          387          372       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.046 *    P=0.113      P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.281N     P=0.137      P=0.058      P=0.310N   |  P<0.001 **   P<0.001 **   P=0.015 *    P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.144      P=0.077      P=0.166N   |  P<0.001 **   P<0.001 **   P=0.003 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.302N                                          |  P=0.001 **                                        |
|FISHER EXACT           |               P=0.207      P=0.070      P=0.423N   |               P<0.001 **   P=0.014 *    P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 59/60 (98%)  58/60 (97%)  60/60 (100%) 59/60 (98%) | 50/60 (83%)  54/60 (90%)  52/60 (87%)  51/60 (85%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  98.0%       100.0%       100.0%        98.0%      |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%)  9/10 (90%)  10/10 (100%) 10/10 (100%)|  1/10 (10%)   4/10 (40%)   3/10 (30%)   3/10 (30%) |
|TERMINAL (d)           | 17/17 (100%) 12/12 (100%) 17/17 (100%)  1/1 (100%) | 27/28 (96%)  16/16 (100%) 15/15 (100%) 17/18 (94%) |
|FIRST INCIDENCE (DAYS) |   336          351          413          361       |   433          247          387          372       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.130      P=0.365      P<0.001 ** |  P=0.016 *    P=0.001 **   P=0.002 **   P=0.005 ** |
|INCIDENTAL TUMOR       |  P=0.366      P=0.596N     P=0.638      P=0.603    |  P=0.542      P=0.108      P=0.206      P=0.402    |
|LOGISTIC REGRESSION    |  P=0.534      P=0.477N     P=0.903      P=0.720N   |  P=0.135      P=0.032 *    P=0.104      P=0.072    |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.538N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.752N   |               P=0.211      P=0.399      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05132 TEST: 05                                                 PAGE  30
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAFLUOROETHYLENE

                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   453
          Female interim sacrifices(days): 454
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.