National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2904

TDMS Study 05132-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96       
EXPERIMENT: 05132 TEST: 05                                                                                     TIME: 00:43:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 116-14-3        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                   TETRAFLUOROETHYLENE                                  DATE: 04/04/96      
EXPERIMENT: 05132 TEST: 05                                                                                     TIME: 00:43:33      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES85207                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61596B      
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 116-14-3       
                                TETRAFLUOROETHYLENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 33     CENSORED DEATHS 10   TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      336   371   489   509   525   555   559   588   591   593                 |
 |      594   624   632   635   649   659   664   674   677   679                 |
 |      686   690   691   701   702   705   707   708   709   715                 |
 |      716   721   727                                                           |
 |  CENSORED DEATHS                                                               |
 |      453   453   453   453   453   453   453   453   453   453                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 156 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 38     CENSORED DEATHS 10   TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      351   450   470   494   509   529   533   555   555   581                 |
 |      589   592   594   594   594   600   604   612   616   621                 |
 |      627   652   653   659   664   664   681   686   691   698                 |
 |      700   702   705   711   715   716   716   730                             |
 |  CENSORED DEATHS                                                               |
 |      453   453   453   453   453   453   453   453   453   453                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 312 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 33     CENSORED DEATHS 10   TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      413   538   547   559   564   575   576   581   614   614                 |
 |      616   617   617   621   627   631   632   632   635   638                 |
 |      658   663   664   664   674   674   677   688   691   693                 |
 |      723   726   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      453   453   453   453   453   453   453   453   453   453                 |
 |                                                                                |
 ==================================================================================
                                TETRAFLUOROETHYLENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 625 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 49     CENSORED DEATHS 10   TERMINAL 1         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      361   455   481   509   510   523   525   531   544   555                 |
 |      559   571   572   572   583   586   590   593   594   603                 |
 |      604   608   611   616   617   617   617   621   626   626                 |
 |      630   632   632   639   639   639   652   663   663   668                 |
 |      674   688   688   691   695   702   712   721   730                       |
 |  CENSORED DEATHS                                                               |
 |      453   453   453   453   453   453   453   453   453   453                 |
 |                                                                                |
 ==================================================================================
                                TETRAFLUOROETHYLENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.3  96.7  96.7  90.6  78.5  66.5  34.2      |
 |           |                                                                    |
 |           |                                                                    |
 |156 PPM    |   100.0 100.0 100.0  98.3  98.3  94.7  86.6  66.5  48.3  24.2      |
 |           |                                                                    |
 |           |                                                                    |
 |312 PPM    |   100.0 100.0 100.0 100.0  98.3  98.3  96.3  84.3  52.2  34.1      |
 |           |                                                                    |
 |           |                                                                    |
 |625 PPM    |   100.0 100.0 100.0  98.3  98.3  94.3  82.3  58.2  22.1   2.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      156 PPM      312 PPM      625 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       34.2%        24.2%        34.1%         2.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.215      P=0.828      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       629.7        616.1        629.4        606.9    |
 |NATURAL DEATHS (C)      |       (16.9)       (14.0)       (11.1)       (10.3)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       629.5        612.3        629.4        583.4    |
 |(STANDARD ERROR)        |       (15.0)       (14.1)       (13.3)       (11.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                TETRAFLUOROETHYLENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      433   481   481   554   581   621   626   648   649   663                 |
 |      677   685   692   693   698   699   702   707   707   714                 |
 |      721   726                                                                 |
 |  CENSORED DEATHS                                                               |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 312 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 34     CENSORED DEATHS 10   TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      247   413   468   468   517   523   537   557   565   565                 |
 |      574   574   581   583   588   594   597   600   617   618                 |
 |      618   625   638   649   653   675   691   701   704   707                 |
 |      722   723   730   730                                                     |
 |  CENSORED DEATHS                                                               |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 625 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 35     CENSORED DEATHS 10   TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      363   387   469   477   478   504   534   536   544   581                 |
 |      587   587   589   607   608   611   625   652   653   664                 |
 |      668   668   672   674   677   685   698   698   699   702                 |
 |      716   729   733   733   733                                               |
 |  CENSORED DEATHS                                                               |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |                                                                                |
 ==================================================================================
                                TETRAFLUOROETHYLENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1250 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 31     CENSORED DEATHS 11   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      372   378   433   439   461   481   504   509   518   531                 |
 |      538   572   576   579   583   594   603   608   610   621                 |
 |      621   624   628   635   639   653   668   677   678   703                 |
 |      727                                                                       |
 |  CENSORED DEATHS                                                               |
 |      6     454   454   454   454   454   454   454   454   454                 |
 |      454                                                                       |
 |                                                                                |
 ==================================================================================
                                TETRAFLUOROETHYLENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  94.3  94.3  90.3  80.3  56.2      |
 |           |                                                                    |
 |           |                                                                    |
 |312 PPM    |   100.0 100.0  98.3  98.3  96.7  92.6  86.6  64.4  50.3  32.2      |
 |           |                                                                    |
 |           |                                                                    |
 |625 PPM    |   100.0 100.0 100.0  98.3  96.7  90.6  82.6  74.5  60.4  30.2      |
 |           |                                                                    |
 |           |                                                                    |
 |1250 PPM   |   100.0 100.0 100.0 100.0  96.6  89.1  78.7  66.3  47.6  37.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      312 PPM      625 PPM      1250 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.2%        32.2%        30.2%        37.3%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.034      P=0.008      P=0.007      P=0.014  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       643.5        598.6        615.5        573.0    |
 |NATURAL DEATHS (C)      |       (18.2)       (17.3)       (16.6)       (16.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       654.2        610.6        618.2        592.0    |
 |(STANDARD ERROR)        |       (14.4)       (15.3)       (15.0)       (18.1)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        TETRAFLUOROETHYLENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        156 PPM          = 2
                                                        312 PPM          = 3
                                                        625 PPM          = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         |
         |
  112.38 +
         |
         |
         |1                                                    1  241      3      2            3
   96.33 +                                                          1             2  2412 1    3 33
         |                                                                              2 1  12   13 3
P        |                                                                                   422  1   1
E        |                                                                                    4 4 2  21 1  3
R  80.27 +                                                                                        4 42  1  331
C        |                                                                                                   11
E        |                                                                                          4 4 22  331 1  1
N        |                                                                                            4 4222       1 1
T  64.22 +                                                                                              4 422 33
         |                                                                                                  22 3 2 3 111
S        |                                                                                                44     2 2   1 1
U        |                                                                                                 44      3 3
R  48.16 +                                                                                                         2 323 11
V        |                                                                                                  44        222 11
I        |                                                                                                   44        322  3
V        |                                                                                                    44         2211 1
A  32.11 +                                                                                                                22
L        |                                                                                                     4 4 4       2  2
         |                                                                                                         44         2
         |                                                                                                          44 4
   16.05 +
         |                                                                                                             444
         |                                                                                                               444
         |                                                                                                                 4  4
    0.00 +
         |
         -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
          0         10         20         30         40         50         60         70         80         90         100       110

                                                                     WEEK

NOTE: 46 obs hidden.
                                                        TETRAFLUOROETHYLENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        312 PPM          = 2
                                                        625 PPM          = 3
                                                        1250 PPM         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                       2                3 4        1
      |                                         2                3 4  3  2  1     2 1
      |                                                                     44    3 1           1
      |                                                                      4   42      2      1  1
   90 +                                                                          4  3  3 2 2       1      1
      |                                                                                34  2 2  2         11  1
P     |                                                                                 44   33 22
E     |                                                                                  4  4 3    3          1  1
R  80 +                                                                                     44   2233            1 1
C     |                                                                                      4    223 3            111
E     |                                                                                            22 3 3
N     |                                                                                            44                11
T  70 +                                                                                             2 2 33
      |                                                                                               2243 3   3      11
S     |                                                                                                2442
U     |                                                                                                  44    3 3     11
R  60 +                                                                                                          33     11
V     |                                                                                                   22 2           11
I     |                                                                                                    4422   33      1 1
V     |                                                                                                     4422
A  50 +                                                                                                      4 2   23
L     |                                                                                                        4  423232
      |                                                                                                           44
      |                                                                                                            4  33
   40 +                                                                                                                2 32
      |                                                                                                                  32 2
      |
      |                                                                                                                     2
   30 +                                                                                                                     3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 36 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.