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https://ntp.niehs.nih.gov/go/3359

TDMS Study 05100-04 Pathology Tables

NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95
Route: DOSED FEED                                                                                                 Time: 14:29:05




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1330-78-5

       Lock Date:  12/13/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          95           95           95           95                                     

  Scheduled Sacrifice                                 45           45           45           44                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            7            2            3                                     
    Moribund Sacrifice                                 4            5            4            3                                     
  Survivors                                                                                                                         
    Natural Death                                      1            1                                                               
    Terminal Sacrifice                                40           37           42           45                                     
  Missing                                                                        2                                                  

  Animals Examined Microscopically                    95           95           93           95                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (80)         (80)         (78)         (80)                                   
      Inflammation                                     1 (1%)                                                                       
   Intestine Small, Duodenum                          (80)         (80)         (78)         (79)                                   
      Ulcer, Chronic Active                                                      1 (1%)       1 (1%)                                
   Intestine Small, Jejunum                           (79)         (80)         (78)         (80)                                   
      Lymphoid Tissue, Hyperplasia                     1 (1%)                    1 (1%)       1 (1%)                                
      Lymphoid Tissue, Ulcer, Chronic Active                                                  1 (1%)                                
   Intestine Small, Ileum                             (79)         (80)         (77)         (80)                                   
      Amyloid Deposition                                                         1 (1%)       1 (1%)                                
      Lymphoid Tissue, Hyperplasia                                                            1 (1%)                                
   Liver                                              (80)         (80)         (78)         (80)                                   
      Angiectasis                                                   1 (1%)                    1 (1%)                                
      Basophilic Focus                                 4 (5%)       3 (4%)       1 (1%)                                             
      Clear Cell Focus                                                                        4 (5%)                                
      Eosinophilic Focus                               8 (10%)      4 (5%)       5 (6%)       7 (9%)                                
      Fatty Change                                                  3 (4%)       1 (1%)       1 (1%)                                
      Hematopoietic Cell Proliferation                 1 (1%)       1 (1%)                                                          
      Infarct                                                       1 (1%)                                                          
      Inflammation, Chronic Active                     1 (1%)       1 (1%)       1 (1%)                                             
      Mixed Cell Focus                                 1 (1%)                    2 (3%)       2 (3%)                                
      Necrosis                                         3 (4%)       2 (3%)       2 (3%)       2 (3%)                                
      Pigmentation, Ceroid                                                       1 (1%)       2 (3%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
      Bile Duct, Cyst                                  1 (1%)                                                                       
      Centrilobular, Degeneration                                   1 (1%)                                                          
      Serosa, Inflammation                                          1 (1%)                                                          
   Mesentery                                          (6)          (5)          (6)          (3)                                    
      Hemorrhage                                                    1 (20%)                                                         
      Inflammation, Chronic Active                                  1 (20%)      1 (17%)      1 (33%)                               
      Inflammation, Suppurative                                     1 (20%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    4 (67%)      1 (20%)      5 (83%)      2 (67%)                               
   Pancreas                                           (80)         (80)         (78)         (80)                                   
      Atrophy                                          4 (5%)       6 (8%)       4 (5%)       1 (1%)                                
      Hyperplasia                                                                1 (1%)                                             
      Duct, Cyst                                       1 (1%)       2 (3%)                    1 (1%)                                
   Salivary Glands                                    (79)         (80)         (78)         (80)                                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Duct, Hyperplasia                                             1 (1%)                                                          
   Stomach, Forestomach                               (80)         (80)         (78)         (80)                                   
      Hyperplasia                                      2 (3%)                    1 (1%)       1 (1%)                                
   Stomach, Glandular                                 (80)         (80)         (78)         (80)                                   
      Cyst                                                                                    1 (1%)                                
      Erosion                                          1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (1)                                                 
      Mineralization                                   1 (100%)                                                                     
      Polyarteritis                                                              1 (100%)                                           
   Heart                                              (80)         (80)         (78)         (80)                                   
      Degeneration                                                  1 (1%)                                                          
      Infarct                                          1 (1%)                                                                       
      Inflammation, Chronic Active                                  1 (1%)       1 (1%)       1 (1%)                                
      Mineralization                                   1 (1%)                                                                       
      Artery, Inflammation, Chronic Active                                       1 (1%)                                             
      Atrium, Thrombosis                                            1 (1%)                                                          
      Pericardium, Inflammation, Chronic Active                     2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (79)         (78)         (80)                                   
      Accessory Adrenal Cortical Nodule                5 (6%)       6 (8%)       4 (5%)       1 (1%)                                
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia                                      4 (5%)       1 (1%)       7 (9%)       2 (3%)                                
      Pigmentation, Ceroid                            68 (85%)     69 (87%)     67 (86%)     71 (89%)                               
      Subcapsular, Hyperplasia                        80 (100%)    79 (100%)    74 (95%)     80 (100%)                              
   Adrenal Medulla                                    (80)         (79)         (78)         (78)                                   
      Hyperplasia                                      1 (1%)       3 (4%)       1 (1%)       4 (5%)                                
   Islets, Pancreatic                                 (80)         (80)         (78)         (80)                                   
      Hyperplasia                                      2 (3%)       5 (6%)       2 (3%)                                             
   Parathyroid Gland                                  (71)         (67)         (66)         (67)                                   
      Cyst                                                          1 (1%)                    1 (1%)                                
      Hyperplasia                                      1 (1%)                                                                       
   Pituitary Gland                                    (76)         (76)         (76)         (79)                                   
      Angiectasis                                                                             2 (3%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                             2 (3%)       1 (1%)                                                          
      Pars Distalis, Hyperplasia                      21 (28%)     23 (30%)     21 (28%)     19 (24%)                               
      Pars Intermedia, Hyperplasia                                               1 (1%)       1 (1%)                                
   Thyroid Gland                                      (79)         (80)         (78)         (80)                                   
      Inflammation                                     1 (1%)                    1 (1%)       3 (4%)                                
      Follicle, Cyst                                   3 (4%)                    2 (3%)       4 (5%)                                
      Follicular Cell, Hyperplasia                     7 (9%)       9 (11%)     13 (17%)     15 (19%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (2)          (1)          (1)          (1)                                    
      Duct, Dilatation                                 2 (100%)     1 (100%)     1 (100%)     1 (100%)                              
   Ovary                                              (78)         (80)         (77)         (79)                                   
      Angiectasis                                      1 (1%)                    1 (1%)       1 (1%)                                
      Atrophy                                          5 (6%)       1 (1%)       2 (3%)       1 (1%)                                
      Cyst                                            16 (21%)     13 (16%)     16 (21%)     22 (28%)                               
      Hyperplasia, Cystic                                                        1 (1%)                                             
      Inflammation, Suppurative                                     1 (1%)                                                          
      Thrombosis                                                    1 (1%)                                                          
      Corpus Luteum, Hyperplasia                       1 (1%)       1 (1%)                                                          
      Periovarian Tissue, Inflammation,                                                                                             
          Granulomatous                                                                       1 (1%)                                
      Rete Ovarii, Hyperplasia                                                                2 (3%)                                
   Uterus                                             (80)         (80)         (78)         (80)                                   
      Angiectasis                                      1 (1%)                    2 (3%)       2 (3%)                                
      Hemorrhage                                                    1 (1%)                                                          
      Hyperplasia, Cystic                             61 (76%)     53 (66%)     53 (68%)     57 (71%)                               
      Inflammation, Suppurative                                     1 (1%)                                                          
      Thrombosis                                                                              2 (3%)                                
      Lymphatic, Angiectasis                                                     1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (80)         (80)         (78)         (80)                                   
      Hyperplasia                                     10 (13%)      6 (8%)       5 (6%)       6 (8%)                                
      Infarct                                          1 (1%)                                                                       
      Myelofibrosis                                   18 (23%)     23 (29%)     27 (35%)     26 (33%)                               
   Lymph Node                                         (3)          (4)          (3)                                                 
      Mediastinal, Pigmentation, Hemosiderin                                     1 (33%)                                            
   Lymph Node, Mandibular                             (75)         (77)         (78)         (76)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (1%)                    3 (4%)       2 (3%)                                
      Hyperplasia, Plasma Cell                         1 (1%)                                                                       
   Lymph Node, Mesenteric                             (78)         (75)         (75)         (78)                                   
      Cyst                                                                                    1 (1%)                                
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia, Lymphoid                            1 (1%)                    3 (4%)       6 (8%)                                
   Spleen                                             (80)         (80)         (78)         (80)                                   
      Depletion Lymphoid                               2 (3%)       1 (1%)       1 (1%)       1 (1%)                                
      Fibrosis                                         1 (1%)                                                                       
      Hematopoietic Cell Proliferation                23 (29%)     20 (25%)     18 (23%)     26 (33%)                               
      Hyperplasia, Lymphoid                            5 (6%)       7 (9%)       4 (5%)       8 (10%)                               
   Thymus                                             (75)         (74)         (77)         (74)                                   
      Cyst                                                                       1 (1%)       1 (1%)                                
      Depletion Lymphoid                               3 (4%)       9 (12%)      1 (1%)       4 (5%)                                
      Hyperplasia, Lymphoid                            2 (3%)       2 (3%)       1 (1%)       3 (4%)                                
      Artery, Inflammation, Chronic Active             1 (1%)                                                                       
      Capsule, Inflammation, Chronic                                1 (1%)                                                          
      Epithelial Cell, Hyperplasia                                  1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (79)         (79)         (75)         (80)                                   
      Hyperplasia, Cystic                              1 (1%)                    1 (1%)       2 (3%)                                
   Skin                                               (80)         (80)         (78)         (80)                                   
      Inflammation, Chronic Active                     1 (1%)                                 1 (1%)                                
      Ulcer                                            1 (1%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (80)         (78)         (80)                                   
      Joint, Inflammation, Chronic Active              2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (80)         (78)         (80)                                   
      Necrosis                                                      3 (4%)       1 (1%)       3 (4%)                                
   Peripheral Nerve                                   (95)         (95)         (93)         (95)                                   
      Axon, Degeneration                               5 (5%)       6 (6%)       4 (4%)      12 (13%)                               
   Spinal Cord                                        (95)         (95)         (93)         (95)                                   
      Degeneration                                                                            1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (80)         (78)         (80)                                   
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
      Inflammation, Chronic Active                                  3 (4%)                    2 (3%)                                
      Thrombosis                                       1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (4%)       1 (1%)       2 (3%)       1 (1%)                                
      Artery, Inflammation, Chronic Active                                       2 (3%)                                             
      Pleura, Inflammation, Chronic                                 1 (1%)                                                          
   Nose                                               (80)         (80)         (78)         (80)                                   
      Nasolacrimal Duct, Inflammation                  1 (1%)                                                                       
      Respiratory Epithelium, Inflammation             2 (3%)                                 3 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Cornea, Inflammation                             1 (100%)                                                                     
   Harderian Gland                                    (70)         (60)         (51)         (60)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                      3 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (80)         (78)         (80)                                   
      Hydronephrosis                                   1 (1%)       1 (1%)       1 (1%)       1 (1%)                                
      Infarct                                          2 (3%)       1 (1%)       1 (1%)       1 (1%)                                
      Mineralization                                                                          1 (1%)                                
      Nephropathy                                     31 (39%)     31 (39%)     42 (54%)     38 (48%)                               
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
      Artery, Inflammation, Chronic Active                                       1 (1%)                                             
      Renal Tubule, Dilatation                                      1 (1%)                                                          
   Urinary Bladder                                    (79)         (80)         (77)         (80)                                   
      Artery, Inflammation, Chronic Active             1 (1%)                                 2 (3%)                                
      Serosa, Inflammation, Chronic                                 1 (1%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          95           95           95           95                                     

  Scheduled Sacrifice                                 43           45           45           45                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            1            1            2                                     
    Accidently Killed                                  1                                                                            
    Natural Death                                      4            5            4            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           43           44           42                                     
  Missing                                                           1            1                                                  

  Animals Examined Microscopically                    95           94           94           95                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (80)         (79)         (79)         (80)                                   
      Inflammation                                     1 (1%)                                                                       
   Gallbladder                                        (78)         (77)         (76)         (75)                                   
      Hyperplasia                                      1 (1%)                                                                       
   Intestine Small, Duodenum                          (80)         (79)         (79)         (80)                                   
      Thrombosis                                                    1 (1%)                                                          
   Intestine Small, Jejunum                           (79)         (79)         (79)         (80)                                   
      Serosa, Fibrosis                                                                        1 (1%)                                
   Liver                                              (80)         (79)         (79)         (80)                                   
      Angiectasis                                      1 (1%)                                                                       
      Basophilic Focus                                 1 (1%)       3 (4%)       5 (6%)                                             
      Clear Cell Focus                                 5 (6%)       9 (11%)     18 (23%)     12 (15%)                               
      Eosinophilic Focus                               7 (9%)       4 (5%)      10 (13%)      5 (6%)                                
      Erythrophagocytosis                                                                     1 (1%)                                
      Fatty Change                                     7 (9%)      13 (16%)     28 (35%)     27 (34%)                               
      Hematopoietic Cell Proliferation                              1 (1%)                                                          
      Mixed Cell Focus                                 1 (1%)                    2 (3%)                                             
      Necrosis                                         2 (3%)       2 (3%)       3 (4%)       4 (5%)                                
      Pigmentation, Ceroid                                                      34 (43%)     31 (39%)                               
      Vacuolization Cytoplasmic, Focal                 1 (1%)                                                                       
      Bile Duct, Cyst                                               1 (1%)                                                          
      Bile Duct, Hyperplasia                           1 (1%)                                                                       
      Serosa, Inflammation                             1 (1%)                                                                       
   Mesentery                                                                    (2)          (2)                                    
      Inflammation, Chronic Active                                               1 (50%)                                            
      Fat, Necrosis                                                              1 (50%)      2 (100%)                              
   Pancreas                                           (80)         (79)         (79)         (80)                                   
      Atrophy                                          3 (4%)       5 (6%)       3 (4%)       1 (1%)                                
      Cyst                                             1 (1%)                                                                       
      Duct, Cyst                                       1 (1%)                    1 (1%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (80)         (79)         (79)         (80)                                   
      Duct, Hyperplasia                                1 (1%)                                                                       
   Stomach, Forestomach                               (80)         (79)         (79)         (80)                                   
      Hyperplasia                                      2 (3%)       1 (1%)                    1 (1%)                                
   Stomach, Glandular                                 (80)         (79)         (79)         (80)                                   
      Erosion                                          1 (1%)                                 1 (1%)                                
      Hyperplasia                                      1 (1%)       1 (1%)                                                          
   Tooth                                              (3)          (3)          (2)          (1)                                    
      Inflammation, Chronic Active                     1 (33%)      1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Polyarteritis                                    1 (100%)                                                                     
   Heart                                              (80)         (79)         (79)         (80)                                   
      Inflammation, Chronic Active                                               3 (4%)       1 (1%)                                
      Mineralization                                                             2 (3%)       2 (3%)                                
      Artery, Inflammation, Chronic Active                          1 (1%)                                                          
      Atrium, Thrombosis                               1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (79)         (79)         (80)                                   
      Accessory Adrenal Cortical Nodule                2 (3%)       2 (3%)       3 (4%)       4 (5%)                                
      Hyperplasia                                     26 (33%)     23 (29%)     31 (39%)     26 (33%)                               
      Pigmentation, Ceroid                            68 (85%)     70 (89%)     72 (91%)     75 (94%)                               
      Subcapsular, Hyperplasia                        62 (78%)     64 (81%)     64 (81%)     61 (76%)                               
   Adrenal Medulla                                    (79)         (79)         (79)         (78)                                   
      Hyperplasia                                      3 (4%)       1 (1%)                    2 (3%)                                
   Islets, Pancreatic                                 (80)         (79)         (79)         (80)                                   
      Hyperplasia                                      9 (11%)     11 (14%)     10 (13%)     15 (19%)                               
   Parathyroid Gland                                  (74)         (69)         (71)         (72)                                   
      Cyst                                                                       1 (1%)                                             
   Pituitary Gland                                    (78)         (79)         (74)         (74)                                   
      Cyst                                             4 (5%)       2 (3%)                    4 (5%)                                
      Pars Distalis, Hyperplasia                       2 (3%)       1 (1%)       2 (3%)       2 (3%)                                
   Thyroid Gland                                      (80)         (79)         (79)         (80)                                   
      Follicle, Cyst                                                1 (1%)       1 (1%)       1 (1%)                                
      Follicular Cell, Hyperplasia                                               1 (1%)       1 (1%)                                
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (79)         (79)         (80)                                   
      Atrophy                                          1 (1%)                                                                       
      Granuloma Sperm                                                            4 (5%)                                             
      Inflammation, Chronic Active                     2 (3%)                                                                       
      Inflammation, Granulomatous                                                             2 (3%)                                
   Preputial Gland                                    (45)         (39)         (46)         (45)                                   
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                        6 (13%)      4 (10%)      3 (7%)       3 (7%)                                
      Duct, Dilatation                                44 (98%)     38 (97%)     45 (98%)     44 (98%)                               
   Prostate                                           (80)         (79)         (79)         (80)                                   
      Inflammation, Suppurative                        1 (1%)                                                                       
   Seminal Vesicle                                    (80)         (79)         (79)         (80)                                   
      Dilatation                                                                 1 (1%)                                             
      Hemorrhage, Acute                                                          1 (1%)                                             
      Inflammation, Chronic Active                     1 (1%)                    2 (3%)                                             
   Testes                                             (80)         (79)         (79)         (80)                                   
      Atrophy                                          1 (1%)                    2 (3%)       3 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (80)         (79)         (79)         (80)                                   
      Granuloma                                        1 (1%)                                 1 (1%)                                
      Hyperplasia                                      7 (9%)      10 (13%)      9 (11%)      8 (10%)                               
      Myelofibrosis                                                              1 (1%)                                             
   Lymph Node                                         (1)          (2)          (1)                                                 
      Inguinal, Hyperplasia, Lymphoid                  1 (100%)                                                                     
   Lymph Node, Mandibular                             (78)         (75)         (73)         (75)                                   
      Depletion Lymphoid                               1 (1%)                                                                       
      Hematopoietic Cell Proliferation                                                        2 (3%)                                
      Hyperplasia, Lymphoid                            1 (1%)       1 (1%)       1 (1%)       1 (1%)                                
   Lymph Node, Mesenteric                             (76)         (76)         (76)         (76)                                   
      Cyst                                             1 (1%)                                                                       
      Hematopoietic Cell Proliferation                 1 (1%)       1 (1%)                    2 (3%)                                
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
   Spleen                                             (80)         (79)         (79)         (79)                                   
      Angiectasis                                                                2 (3%)       1 (1%)                                
      Depletion Lymphoid                               5 (6%)                    4 (5%)       2 (3%)                                
      Hematocyst                                                    1 (1%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                15 (19%)     19 (24%)     15 (19%)     18 (23%)                               
      Hyperplasia, Lymphoid                            1 (1%)                    1 (1%)       2 (3%)                                
   Thymus                                             (73)         (72)         (74)         (75)                                   
      Atrophy                                                                                 2 (3%)                                
      Cyst                                             1 (1%)                                                                       
      Depletion Lymphoid                               4 (5%)       3 (4%)       3 (4%)       9 (12%)                               
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
      Necrosis                                                                   1 (1%)                                             
      Epithelial Cell, Hyperplasia                                                            1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (80)         (79)         (79)         (80)                                   
      Abscess                                          1 (1%)                                                                       
      Cyst Epithelial Inclusion                                     1 (1%)                    1 (1%)                                
      Granuloma                                        1 (1%)                                                                       
      Hemorrhage                                       1 (1%)                                                                       
      Inflammation, Chronic Active                                  1 (1%)                    1 (1%)                                
      Ulcer                                                         1 (1%)       1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (79)         (79)         (80)                                   
      Infiltration Cellular, Lipocyte                  1 (1%)                                                                       
      Necrosis                                         1 (1%)       1 (1%)       1 (1%)                                             
   Peripheral Nerve                                   (95)         (94)         (94)         (95)                                   
      Axon, Degeneration                               4 (4%)       2 (2%)       3 (3%)       3 (3%)                                
   Spinal Cord                                        (95)         (94)         (94)         (95)                                   
      Cyst                                                                                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (79)         (79)         (80)                                   
      Inflammation, Chronic Active                     1 (1%)                    6 (8%)                                             
      Thrombosis                                                                 1 (1%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (4%)       5 (6%)       2 (3%)       2 (3%)                                
      Alveolus, Pigmentation, Hemosiderin              1 (1%)                                                                       
      Bronchiole, Hyperplasia                                                    1 (1%)       1 (1%)                                
   Nose                                               (80)         (79)         (79)         (80)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05100-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:05  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Developmental Malformation                                                              1 (1%)                                
      Proliferation Connective Tissue                  1 (1%)                                                                       
      Nasolacrimal Duct, Inflammation                                            1 (1%)       2 (3%)                                
      Respiratory Epithelium, Inflammation             1 (1%)                    1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                       (1)                                    
      Atrophy                                                                                 1 (100%)                              
      Cornea, Inflammation                             1 (100%)     1 (100%)                                                        
   Harderian Gland                                    (71)         (63)         (66)         (60)                                   
      Hyperplasia                                      2 (3%)       1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (79)         (79)         (80)                                   
      Cyst                                             2 (3%)       5 (6%)       3 (4%)       1 (1%)                                
      Hydronephrosis                                                             1 (1%)       1 (1%)                                
      Infarct                                          2 (3%)                    1 (1%)       1 (1%)                                
      Inflammation, Suppurative                        2 (3%)                                                                       
      Nephropathy                                     61 (76%)     62 (78%)     62 (78%)     59 (74%)                               
      Artery, Inflammation, Chronic Active             1 (1%)                                                                       
      Renal Tubule, Necrosis                                                                  1 (1%)                                
   Urinary Bladder                                    (80)         (79)         (79)         (79)                                   
      Inflammation, Suppurative                        2 (3%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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