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TDMS Study 05100-04 Pathology Tables

NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95
Route: DOSED FEED                                                                                                 Time: 14:29:17




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1330-78-5

       Lock Date:  12/13/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          95           95           95           95                                     

  Scheduled Sacrifice                                 45           45           45           44                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            7            2            3                                     
    Moribund Sacrifice                                 4            5            4            3                                     
  Survivors                                                                                                                         
    Natural Death                                      1            1                                                               
    Terminal Sacrifice                                40           37           42           45                                     
  Missing                                                                        2                                                  

  Animals Examined Microscopically                    95           95           93           95                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (79)         (78)         (77)         (80)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (1%)                                                          
   Intestine Large, Rectum                            (80)         (78)         (78)         (80)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
   Intestine Small, Jejunum                           (79)         (80)         (78)         (80)                                   
   Liver                                              (80)         (80)         (78)         (80)                                   
      Hemangiosarcoma, Metastatic, Spleen                           1 (1%)                                                          
      Hepatocellular Carcinoma                         9 (11%)      2 (3%)       1 (1%)       5 (6%)                                
      Hepatocellular Carcinoma, Multiple               1 (1%)       1 (1%)                    1 (1%)                                
      Hepatocellular Adenoma                           8 (10%)     12 (15%)     10 (13%)      8 (10%)                               
      Hepatocellular Adenoma, Multiple                 5 (6%)       1 (1%)       3 (4%)       8 (10%)                               
      Hepatocholangiocarcinoma                                      1 (1%)                                                          
      Histiocytic Sarcoma                                           2 (3%)       1 (1%)                                             
   Mesentery                                          (6)          (5)          (6)          (3)                                    
      Fibrosarcoma, Metastatic, Skin                   1 (17%)      1 (20%)                                                         
   Pancreas                                           (80)         (80)         (78)         (80)                                   
   Salivary Glands                                    (79)         (80)         (78)         (80)                                   
   Stomach, Forestomach                               (80)         (80)         (78)         (80)                                   
      Squamous Cell Papilloma                                       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (80)         (78)         (80)                                   
      Hemangiosarcoma                                  1 (1%)                                                                       
      Histiocytic Sarcoma                                           1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (79)         (78)         (80)                                   
      Adenoma                                          1 (1%)                                 1 (1%)                                
      Subcapsular, Adenoma                             3 (4%)                                                                       
   Adrenal Medulla                                    (80)         (79)         (78)         (78)                                   
      Pheochromocytoma Benign                          2 (3%)                    1 (1%)                                             
   Islets, Pancreatic                                 (80)         (80)         (78)         (80)                                   
      Carcinoma                                        1 (1%)                                                                       
   Parathyroid Gland                                  (71)         (67)         (66)         (67)                                   
   Pituitary Gland                                    (76)         (76)         (76)         (79)                                   
      Pars Distalis, Adenoma                           6 (8%)       8 (11%)      6 (8%)       9 (11%)                               
      Pars Intermedia, Adenoma                                      1 (1%)                    2 (3%)                                
   Thyroid Gland                                      (79)         (80)         (78)         (80)                                   
      Follicular Cell, Adenoma                         1 (1%)                    1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Leiomyoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (78)         (80)         (77)         (79)                                   
      Cystadenoma                                                                1 (1%)       2 (3%)                                
      Fibrous Histiocytoma                                                                    1 (1%)                                
      Granulosa Cell Tumor Malignant                   1 (1%)                                                                       
      Hemangioma                                                                 1 (1%)                                             
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Luteoma                                                       1 (1%)                                                          
      Teratoma NOS                                     1 (1%)                                                                       
   Uterus                                             (80)         (80)         (78)         (80)                                   
      Hemangioma                                                                 1 (1%)                                             
      Histiocytic Sarcoma                              1 (1%)       2 (3%)       1 (1%)       1 (1%)                                
      Polyp Stromal                                    1 (1%)       1 (1%)       3 (4%)                                             
      Polyp Stromal, Multiple                          1 (1%)                                                                       
      Serosa, Fibrosarcoma, Metastatic, Skin           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                                     (1)                                    
   Bone Marrow                                        (80)         (80)         (78)         (80)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
      Sarcoma                                                                                 1 (1%)                                
   Lymph Node                                         (3)          (4)          (3)                                                 

                                                             Page   3                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Lumbar, Renal, Thoracic, Iliac, Bronchial,                                                                                    
           Mediastinal, Lymphoma Malignant Mixed                                 1 (33%)                                            
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (33%)                                                                      
      Mediastinal, Histiocytic Sarcoma                              1 (25%)                                                         
      Pancreatic, Hepatocholangiocarcinoma,                                                                                         
          Metastatic, Liver                                         1 (25%)                                                         
      Renal, Histiocytic Sarcoma                                                 1 (33%)                                            
   Lymph Node, Mandibular                             (75)         (77)         (78)         (76)                                   
      Histiocytic Sarcoma                                           1 (1%)       1 (1%)                                             
   Lymph Node, Mesenteric                             (78)         (75)         (75)         (78)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (1%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (1%)                                                          
      Histiocytic Sarcoma                                           2 (3%)       1 (1%)                                             
   Spleen                                             (80)         (80)         (78)         (80)                                   
      Hemangioma                                                                 1 (1%)                                             
      Hemangiosarcoma                                  3 (4%)       1 (1%)       1 (1%)       1 (1%)                                
      Histiocytic Sarcoma                                           2 (3%)       2 (3%)                                             
   Thymus                                             (75)         (74)         (77)         (74)                                   
      Histiocytic Sarcoma                                                        1 (1%)                                             
      Thymoma Malignant                                                          1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (79)         (79)         (75)         (80)                                   
      Adenocarcinoma                                                                          1 (1%)                                
   Skin                                               (80)         (80)         (78)         (80)                                   
      Fibrosarcoma                                     2 (3%)       1 (1%)       1 (1%)                                             
      Hemangioma                                                                 1 (1%)                                             
      Sarcoma                                                                                 1 (1%)                                
      Subcutaneous Tissue, Myxosarcoma                              1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (80)         (78)         (80)                                   
      Vertebra, Osteosarcoma                                                                  1 (1%)                                
   Skeletal Muscle                                    (2)                       (1)                                                 
      Fibrosarcoma, Multiple, Metastatic, Skin         1 (50%)                                                                      
      Sarcoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (80)         (78)         (80)                                   
      Meninges, Myxosarcoma, Metastatic, Skin                       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (80)         (78)         (80)                                   
      Adenocarcinoma, Metastatic, Harderian Gland      1 (1%)                                                                       
      Alveolar/Bronchiolar Adenoma                     2 (3%)       4 (5%)       3 (4%)       5 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (1%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (4%)       1 (1%)       2 (3%)       1 (1%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (1%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   2 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      5 (6%)       1 (1%)       1 (1%)       2 (3%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (1%)                                                          
      Histiocytic Sarcoma                                           2 (3%)       1 (1%)                                             
      Osteosarcoma, Multiple, Metastatic, Bone                                                1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (2)                                                 
      Pinna, Fibrosarcoma                                                        1 (50%)                                            
   Harderian Gland                                    (70)         (60)         (51)         (60)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          5 (7%)       3 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (80)         (78)         (80)                                   
      Renal Tubule, Adenoma                            1 (1%)                                                                       
   Urinary Bladder                                    (79)         (80)         (77)         (80)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(95)        *(95)        *(93)        *(95)                                   
      Histiocytic Sarcoma                              1 (1%)       3 (3%)       2 (2%)       1 (1%)                                
      Leukemia Lymphocytic                                                                    1 (1%)                                
      Lymphoma Malignant Lymphocytic                                3 (3%)       3 (3%)       3 (3%)                                
      Lymphoma Malignant Mixed                         3 (3%)                    2 (2%)       3 (3%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (1%)       3 (3%)       1 (1%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          41          33          42                                       
     Total Primary Neoplasms                           66          49          49          56                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          31          25          32                                       
     Total Benign Neoplasms                            37          32          33          35                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          16          15          19                                       
     Total Malignant Neoplasms                         28          17          16          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           5           1           3                                       
     Total Metastatic Neoplasm                         13           8           1           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          95           95           95           95                                     

  Scheduled Sacrifice                                 43           45           45           45                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            1            1            2                                     
    Accidently Killed                                  1                                                                            
    Natural Death                                      4            5            4            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           43           44           42                                     
  Missing                                                           1            1                                                  

  Animals Examined Microscopically                    95           94           94           95                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (78)         (77)         (76)         (75)                                   
      Adenoma                                          1 (1%)                                                                       
   Intestine Large, Colon                             (80)         (78)         (79)         (80)                                   
   Intestine Small, Jejunum                           (79)         (79)         (79)         (80)                                   
      Adenocarcinoma                                                                          2 (3%)                                
   Liver                                              (80)         (79)         (79)         (80)                                   
      Hemangioma                                       1 (1%)                                                                       
      Hemangiosarcoma                                                            2 (3%)                                             
      Hemangiosarcoma, Multiple                                                  1 (1%)                                             
      Hemangiosarcoma, Metastatic, Spleen                           1 (1%)                                                          
      Hepatocellular Carcinoma                        12 (15%)     11 (14%)      8 (10%)     12 (15%)                               
      Hepatocellular Carcinoma, Multiple               3 (4%)       2 (3%)       2 (3%)       3 (4%)                                
      Hepatocellular Adenoma                          15 (19%)     13 (16%)     11 (14%)     13 (16%)                               
      Hepatocellular Adenoma, Multiple                 8 (10%)      6 (8%)       8 (10%)      7 (9%)                                
      Histiocytic Sarcoma                                           2 (3%)                    2 (3%)                                
      Ito Cell Tumor Benign                                                                   1 (1%)                                
      Schwannoma Malignant, Metastatic, Nose                                     1 (1%)                                             
   Stomach, Forestomach                               (80)         (79)         (79)         (80)                                   
      Squamous Cell Carcinoma                          1 (1%)                                                                       
      Squamous Cell Papilloma                                                    2 (3%)                                             
   Tooth                                              (3)          (3)          (2)          (1)                                    
      Odontoma                                         2 (67%)      2 (67%)      2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (79)         (79)         (80)                                   
      Hemangiosarcoma                                               1 (1%)                                                          
      Hemangiosarcoma, Metastatic, Bone Marrow                                                1 (1%)                                
      Histiocytic Sarcoma                                           1 (1%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (79)         (79)         (80)                                   
      Adenoma                                          1 (1%)                    1 (1%)       1 (1%)                                
      Bilateral, Subcapsular, Adenoma                  1 (1%)       1 (1%)                                                          
      Subcapsular, Adenoma                             1 (1%)       2 (3%)       1 (1%)       2 (3%)                                
   Adrenal Medulla                                    (79)         (79)         (79)         (78)                                   
      Pheochromocytoma Benign                          2 (3%)                                                                       
   Islets, Pancreatic                                 (80)         (79)         (79)         (80)                                   
      Adenoma                                          1 (1%)                    3 (4%)       2 (3%)                                
   Pituitary Gland                                    (78)         (79)         (74)         (74)                                   
      Schwannoma Malignant, Metastatic, Nose                                     1 (1%)                                             
   Thyroid Gland                                      (80)         (79)         (79)         (80)                                   
      Follicular Cell, Adenoma                                                   2 (3%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
      Histiocytic Sarcoma                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (79)         (79)         (80)                                   
      Histiocytic Sarcoma                                           1 (1%)                    1 (1%)                                
   Testes                                             (80)         (79)         (79)         (80)                                   
      Interstitial Cell, Adenoma                                                              1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (80)         (79)         (79)         (80)                                   
      Hemangiosarcoma                                                                         1 (1%)                                
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Mast Cell Tumor Malignant                                                               1 (1%)                                
      Sarcoma, Metastatic, Bone                                                               1 (1%)                                
   Lymph Node                                         (1)          (2)          (1)                                                 
   Lymph Node, Mandibular                             (78)         (75)         (73)         (75)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (1%)                                                          

                                                             Page   8                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                           1 (1%)                                                          
   Lymph Node, Mesenteric                             (76)         (76)         (76)         (76)                                   
      Histiocytic Sarcoma                                           1 (1%)                    1 (1%)                                
   Spleen                                             (80)         (79)         (79)         (79)                                   
      Hemangiosarcoma                                  4 (5%)       1 (1%)       1 (1%)       1 (1%)                                
      Histiocytic Sarcoma                                           1 (1%)                    2 (3%)                                
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                                                              1 (1%)                                
   Thymus                                             (73)         (72)         (74)         (75)                                   
      Histiocytic Sarcoma                                           1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (80)         (79)         (79)         (80)                                   
      Fibrosarcoma                                                  1 (1%)                                                          
      Hemangiosarcoma                                  1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (79)         (79)         (80)                                   
      Hemangiosarcoma, Metastatic, Bone Marrow                                                1 (1%)                                
      Femur, Sarcoma                                                                          1 (1%)                                
   Skeletal Muscle                                    (1)                                    (1)                                    
      Hemangiosarcoma, Metastatic, Bone Marrow                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (79)         (79)         (80)                                   
      Schwannoma Malignant, Metastatic, Nose                                     1 (1%)                                             
      Meninges, Histiocytic Sarcoma                                 1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (79)         (79)         (80)                                   
      Adenocarcinoma, Metastatic, Harderian Gland      1 (1%)       1 (1%)                                                          
      Alveolar/Bronchiolar Adenoma                     7 (9%)       7 (9%)      10 (13%)     10 (13%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (1%)                    2 (3%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (1%)       4 (5%)       2 (3%)       2 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (8%)       6 (8%)       4 (5%)       2 (3%)                                
      Histiocytic Sarcoma                                           1 (1%)                    1 (1%)                                
   Nose                                               (80)         (79)         (79)         (80)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                                                              1 (1%)                                

                                                             Page   9                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Schwannoma Malignant                                                       1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Pinna, Fibrosarcoma                                           1 (100%)                  1 (100%)                              
   Harderian Gland                                    (71)         (63)         (66)         (60)                                   
      Adenocarcinoma                                   1 (1%)       1 (2%)       2 (3%)                                             
      Adenoma                                                       2 (3%)       2 (3%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (79)         (79)         (80)                                   
      Adenocarcinoma                                                1 (1%)                                                          
      Histiocytic Sarcoma                                           1 (1%)                    1 (1%)                                
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(95)        *(94)        *(94)        *(95)                                   
      Histiocytic Sarcoma                                           2 (2%)                    2 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (1%)                    1 (1%)                                             
      Lymphoma Malignant Mixed                         2 (2%)       2 (2%)       1 (1%)       1 (1%)                                
      Lymphoma Malignant Undifferentiated Cell                      1 (1%)                    1 (1%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05100-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 14:29:17  
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         B6C3F1 MICE MALE                           0 PPM        60 PPM      125 PPM      250 PPM                                   
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          38          42          42                                       
     Total Primary Neoplasms                           67          61          65          74                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          24          35          35                                       
     Total Benign Neoplasms                            41          33          44          46                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          23          17          21                                       
     Total Malignant Neoplasms                         26          28          21          28                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           8           5           5                                       
     Total Metastatic Neoplasm                          7           9           7           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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