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TDMS Study 05100-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/09/95       
EXPERIMENT: 05100 TEST: 04                                                                                     TIME: 16:08:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES45050                                ROUTE: DOSED FEED                                              NTP C#: 61041B       
PATHOLOGIST: A. SINGER                                                                                         CAS: 1330-78-5       
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/09/95       
EXPERIMENT: 05100 TEST: 04                                                                                     TIME: 16:08:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES45050                                ROUTE: DOSED FEED                                              NTP C#: 61041B       
PATHOLOGIST: A. SINGER                                                                                         CAS: 1330-78-5       




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/09/95       
EXPERIMENT: 05100 TEST: 04                                                                                     TIME: 16:08:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES45050                                ROUTE: DOSED FEED                                              NTP C#: 61041B       
PATHOLOGIST: A. SINGER                                                                                         CAS: 1330-78-5       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF TRICRESYL PHOSPHATE

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Harderian Gland               Adenoma
              Intestine Small: Jejunum      Carcinoma
              Intestine Small: Site Unspecified
                                            Carcinoma

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Carcinoma

              ====================================================================================================
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/80 (4%)    3/79 (4%)    2/79 (3%)    3/80 (4%)  |  4/80 (5%)    0/79 (0%)    0/78 (0%)    1/80 (1%)  |
|ADJUSTED (b)           |   6.3%         7.0%         3.9%         6.4%      |   8.9%         0.0%         0.0%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   1/10 (10%) |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  2/43 (5%)    3/43 (7%)    1/44 (2%)    2/42 (5%)  |  3/41 (7%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   460 (I)      736 (T)      460 (I)      460 (I)   |   461 (I)      ---          ---          555       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.569N     P=0.661      P=0.494N     P=0.654    |  P=0.123N     P=0.072N     P=0.063N     P=0.172N   |
|INCIDENTAL TUMOR       |  P=0.569N     P=0.661      P=0.494N     P=0.654    |  P=0.102N     P=0.072N     P=0.063N     P=0.116N   |
|LOGISTIC REGRESSION    |  P=0.560N     P=0.660N     P=0.500N     P=0.662N   |  P=0.129N     P=0.068N     P=0.066N     P=0.180N   |
|COCHRAN-ARMITAGE       |  P=0.559N                                          |  P=0.131N                                          |
|FISHER EXACT           |               P=0.653      P=0.506N     P=0.659N   |               P=0.062N     P=0.063N     P=0.184N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/79 (3%)    0/79 (0%)    0/79 (0%)    0/78 (0%)  |  2/80 (3%)    0/79 (0%)    1/78 (1%)    0/78 (0%)  |
|ADJUSTED (b)           |   4.7%         0.0%         0.0%         0.0%      |   4.9%         0.0%         2.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/8 (0%)   |
|TERMINAL (d)           |  2/43 (5%)    0/43 (0%)    0/44 (0%)    0/41 (0%)  |  2/41 (5%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      ---          ---          ---       |   736 (T)      ---          621          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120N     P=0.238N     P=0.233N     P=0.249N   |  P=0.181N     P=0.255N     P=0.494N     P=0.218N   |
|INCIDENTAL TUMOR       |  P=0.120N     P=0.238N     P=0.233N     P=0.249N   |  P=0.146N     P=0.255N     P=0.416N     P=0.218N   |
|LOGISTIC REGRESSION    |  P=0.120N     P=0.238N     P=0.233N     P=0.249N   |  P=0.190N     P=0.255N     P=0.504N     P=0.218N   |
|COCHRAN-ARMITAGE       |  P=0.119N                                          |  P=0.197N                                          |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.252N   |               P=0.252N     P=0.510N     P=0.255N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    2/79 (3%)    2/79 (3%)    5/80 (6%)  |  5/80 (6%)    3/80 (4%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         4.0%         4.5%        11.9%      |  12.2%         7.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    1/43 (2%)    2/44 (5%)    5/42 (12%) |  5/41 (12%)   2/38 (5%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          460 (I)      736 (T)      736 (T)   |   736 (T)      603          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.016 *    P=0.240      P=0.244      P=0.031 *  |  P=0.006N**   P=0.394N     P=0.031N*    P=0.026N*  |
|INCIDENTAL TUMOR       |  P=0.016 *    P=0.240      P=0.244      P=0.031 *  |  P=0.005N**   P=0.323N     P=0.031N*    P=0.026N*  |
|LOGISTIC REGRESSION    |  P=0.017 *    P=0.237      P=0.244      P=0.031 *  |  P=0.007N**   P=0.377N     P=0.031N*    P=0.026N*  |
|COCHRAN-ARMITAGE       |  P=0.018 *                                         |  P=0.008N**                                        |
|FISHER EXACT           |               P=0.245      P=0.245      P=0.029 *  |               P=0.360N     P=0.031N*    P=0.029N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    1/79 (1%)    2/79 (3%)    0/80 (0%)  |  0/80 (0%)    0/80 (0%)    1/78 (1%)    0/80 (0%)  |
|ADJUSTED (b)           |   2.3%         2.3%         4.5%         0.0%      |   0.0%         0.0%         2.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    1/43 (2%)    2/44 (5%)    0/42 (0%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      736 (T)      736 (T)      ---       |   ---          ---          723          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372N     P=0.762      P=0.508      P=0.505N   |  P=0.706        (e)        P=0.514        (e)      |
|INCIDENTAL TUMOR       |  P=0.372N     P=0.762      P=0.508      P=0.505N   |  P=0.517        (e)        P=0.398        (e)      |
|LOGISTIC REGRESSION    |  P=0.372N     P=0.762      P=0.508      P=0.505N   |  P=0.696        (e)        P=0.501        (e)      |
|COCHRAN-ARMITAGE       |  P=0.367N                                          |  P=0.690                                           |
|FISHER EXACT           |               P=0.748      P=0.495      P=0.500N   |                 (e)        P=0.494        (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    3/79 (4%)    3/79 (4%)    5/80 (6%)  |  5/80 (6%)    3/80 (4%)    1/78 (1%)    0/80 (0%)  |
|ADJUSTED (b)           |   2.3%         6.3%         6.8%        11.9%      |  12.2%         7.3%         2.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    2/43 (5%)    3/44 (7%)    5/42 (12%) |  5/41 (12%)   2/38 (5%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      460 (I)      736 (T)      736 (T)   |   736 (T)      603          723          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.076      P=0.307      P=0.314      P=0.098    |  P=0.010N*    P=0.394N     P=0.098N     P=0.026N*  |
|INCIDENTAL TUMOR       |  P=0.076      P=0.307      P=0.314      P=0.098    |  P=0.011N*    P=0.323N     P=0.119N     P=0.026N*  |
|LOGISTIC REGRESSION    |  P=0.081      P=0.306      P=0.314      P=0.098    |  P=0.011N*    P=0.377N     P=0.098N     P=0.026N*  |
|COCHRAN-ARMITAGE       |  P=0.084                                           |  P=0.013N*                                         |
|FISHER EXACT           |               P=0.305      P=0.305      P=0.105    |               P=0.360N     P=0.111N     P=0.029N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    0/79 (0%)    0/79 (0%)    2/80 (3%)  |  0/80 (0%)    0/80 (0%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         4.8%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    0/43 (0%)    0/44 (0%)    2/42 (5%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          736 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.044 *      (e)          (e)        P=0.233    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.044 *      (e)          (e)        P=0.233    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.044 *      (e)          (e)        P=0.233    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.047 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    0/79 (0%)    0/79 (0%)    2/80 (3%)  |  0/80 (0%)    0/80 (0%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         4.8%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    0/43 (0%)    0/44 (0%)    2/42 (5%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          736 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.044 *      (e)          (e)        P=0.233    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.044 *      (e)          (e)        P=0.233    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.044 *      (e)          (e)        P=0.233    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.047 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    0/79 (0%)    3/79 (4%)    2/80 (3%)  |  0/80 (0%)    0/80 (0%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         6.5%         4.8%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    0/43 (0%)    2/44 (5%)    2/42 (5%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      ---          583          736 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.231      P=0.500N     P=0.315      P=0.492    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.172      P=0.500N     P=0.236      P=0.492    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.238      P=0.500N     P=0.312      P=0.492    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.240                                           |    (e)                                             |
|FISHER EXACT           |               P=0.503N     P=0.305      P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    0/79 (0%)    3/79 (4%)    2/80 (3%)  |  1/80 (1%)    0/80 (0%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         6.5%         4.8%      |   2.4%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    0/43 (0%)    2/44 (5%)    2/42 (5%)  |  1/41 (2%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      ---          583          736 (T)   |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.231      P=0.500N     P=0.315      P=0.492    |  P=0.296N     P=0.515N     P=0.495N     P=0.481N   |
|INCIDENTAL TUMOR       |  P=0.172      P=0.500N     P=0.236      P=0.492    |  P=0.296N     P=0.515N     P=0.495N     P=0.481N   |
|LOGISTIC REGRESSION    |  P=0.238      P=0.500N     P=0.312      P=0.492    |  P=0.296N     P=0.515N     P=0.495N     P=0.481N   |
|COCHRAN-ARMITAGE       |  P=0.240                                           |  P=0.310N                                          |
|FISHER EXACT           |               P=0.503N     P=0.305      P=0.500    |               P=0.500N     P=0.506N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    0/79 (0%)    3/79 (4%)    0/80 (0%)  |  0/80 (0%)    0/80 (0%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.2%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    0/43 (0%)    2/44 (5%)    0/42 (0%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          460 (I)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.531        (e)        P=0.126        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.531        (e)        P=0.126        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.535        (e)        P=0.122        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.535                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.120        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/80 (29%)  19/79 (24%)  19/79 (24%)  20/80 (25%) | 13/80 (16%)  13/80 (16%)  13/78 (17%)  16/80 (20%) |
|ADJUSTED (b)           |  44.6%        42.7%        40.7%        42.7%      |  29.6%        30.5%        31.0%        33.8%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  3/10 (30%)   0/10 (0%)    2/10 (20%)   2/10 (20%) |  1/10 (10%)   2/10 (20%)   0/10 (0%)    1/9 (11%)  |
|TERMINAL (d)           | 16/43 (37%)  18/43 (42%)  17/44 (39%)  16/42 (38%) | 11/41 (27%)  10/38 (26%)  13/42 (31%)  14/45 (31%) |
|FIRST INCIDENCE (DAYS) |   281 (I)      281 (I)      460 (I)      460 (I)   |   461 (I)      461 (I)      736 (T)      461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.393N     P=0.286N     P=0.262N     P=0.383N   |  P=0.395      P=0.517      P=0.564N     P=0.424    |
|INCIDENTAL TUMOR       |  P=0.405N     P=0.423N     P=0.317N     P=0.359N   |  P=0.349      P=0.577      P=0.534N     P=0.405    |
|LOGISTIC REGRESSION    |  P=0.363N     P=0.282N     P=0.271N     P=0.352N   |  P=0.306      P=0.563      P=0.587      P=0.356    |
|COCHRAN-ARMITAGE       |  P=0.370N                                          |  P=0.279                                           |
|FISHER EXACT           |               P=0.312N     P=0.312N     P=0.361N   |               P=0.585N     P=0.557      P=0.341    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/80 (19%)  13/79 (16%)  10/79 (13%)  15/80 (19%) | 10/80 (13%)   3/80 (4%)    1/78 (1%)    6/80 (8%)  |
|ADJUSTED (b)           |  32.5%        27.2%        21.3%        34.0%      |  22.9%         7.2%         2.2%        12.7%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           | 12/43 (28%)   9/43 (21%)   7/44 (16%)  13/42 (31%) |  8/41 (20%)   2/38 (5%)    0/42 (0%)    4/45 (9%)  |
|FIRST INCIDENCE (DAYS) |   553          460 (I)      667          676       |   538          561          621          555       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.511      P=0.413N     P=0.174N     P=0.559    |  P=0.179N     P=0.051N     P=0.006N**   P=0.170N   |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.336N     P=0.093N     P=0.574N   |  P=0.217N     P=0.036N*    P=0.009N**   P=0.267N   |
|LOGISTIC REGRESSION    |  P=0.508      P=0.535N     P=0.162N     P=0.579N   |  P=0.293N     P=0.042N*    P=0.006N**   P=0.260N   |
|COCHRAN-ARMITAGE       |  P=0.533                                           |  P=0.224N                                          |
|FISHER EXACT           |               P=0.432N     P=0.201N     P=0.580N   |               P=0.040N*    P=0.005N**   P=0.215N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/80 (41%)  28/79 (35%)  26/79 (33%)  30/80 (38%) | 22/80 (28%)  16/80 (20%)  14/78 (18%)  19/80 (24%) |
|ADJUSTED (b)           |  62.7%        57.8%        52.7%        63.4%      |  48.3%        36.8%        32.5%        39.3%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  3/10 (30%)   1/10 (10%)   2/10 (20%)   2/10 (20%) |  1/10 (10%)   2/10 (20%)   0/10 (0%)    1/9 (11%)  |
|TERMINAL (d)           | 24/43 (56%)  23/43 (53%)  21/44 (48%)  25/42 (60%) | 18/41 (44%)  12/38 (32%)  13/42 (31%)  16/45 (36%) |
|FIRST INCIDENCE (DAYS) |   281 (I)      281 (I)      460 (I)      460 (I)   |   461 (I)      461 (I)      621          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.413N     P=0.244N     P=0.131N     P=0.402N   |  P=0.249N     P=0.227N     P=0.069N     P=0.250N   |
|INCIDENTAL TUMOR       |  P=0.323N     P=0.239N     P=0.091N     P=0.339N   |  P=0.290N     P=0.160N     P=0.076N     P=0.300N   |
|LOGISTIC REGRESSION    |  P=0.367N     P=0.232N     P=0.122N     P=0.354N   |  P=0.341N     P=0.179N     P=0.078N     P=0.320N   |
|COCHRAN-ARMITAGE       |  P=0.381N                                          |  P=0.391N                                          |
|FISHER EXACT           |               P=0.278N     P=0.178N     P=0.373N   |               P=0.177N     P=0.107N     P=0.359N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/80 (41%)  28/79 (35%)  26/79 (33%)  30/80 (38%) | 22/80 (28%)  16/80 (20%)  14/78 (18%)  19/80 (24%) |
|ADJUSTED (b)           |  62.7%        57.8%        52.7%        63.4%      |  48.3%        36.8%        32.5%        39.3%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  3/10 (30%)   1/10 (10%)   2/10 (20%)   2/10 (20%) |  1/10 (10%)   2/10 (20%)   0/10 (0%)    1/9 (11%)  |
|TERMINAL (d)           | 24/43 (56%)  23/43 (53%)  21/44 (48%)  25/42 (60%) | 18/41 (44%)  12/38 (32%)  13/42 (31%)  16/45 (36%) |
|FIRST INCIDENCE (DAYS) |   281 (I)      281 (I)      460 (I)      460 (I)   |   461 (I)      461 (I)      621          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.413N     P=0.244N     P=0.131N     P=0.402N   |  P=0.249N     P=0.227N     P=0.069N     P=0.250N   |
|INCIDENTAL TUMOR       |  P=0.323N     P=0.239N     P=0.091N     P=0.339N   |  P=0.290N     P=0.160N     P=0.076N     P=0.300N   |
|LOGISTIC REGRESSION    |  P=0.367N     P=0.232N     P=0.122N     P=0.354N   |  P=0.341N     P=0.179N     P=0.078N     P=0.320N   |
|COCHRAN-ARMITAGE       |  P=0.381N                                          |  P=0.391N                                          |
|FISHER EXACT           |               P=0.278N     P=0.178N     P=0.373N   |               P=0.177N     P=0.107N     P=0.359N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/80 (10%)   7/79 (9%)   12/79 (15%)  12/80 (15%) |  2/80 (3%)    4/80 (5%)    4/78 (5%)    5/80 (6%)  |
|ADJUSTED (b)           |  16.7%        16.3%        25.7%        27.4%      |   4.9%        10.5%         8.8%        11.1%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/9 (0%)   |
|TERMINAL (d)           |  5/43 (12%)   7/43 (16%)  10/44 (23%)  11/42 (26%) |  2/41 (5%)    4/38 (11%)   3/42 (7%)    5/45 (11%) |
|FIRST INCIDENCE (DAYS) |   460 (I)      736 (T)      460 (I)      460 (I)   |   736 (T)      736 (T)      461 (I)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.112      P=0.501N     P=0.252      P=0.218    |  P=0.249      P=0.302      P=0.348      P=0.256    |
|INCIDENTAL TUMOR       |  P=0.088      P=0.500      P=0.217      P=0.129    |  P=0.249      P=0.302      P=0.348      P=0.256    |
|LOGISTIC REGRESSION    |  P=0.121      P=0.494N     P=0.242      P=0.232    |  P=0.215      P=0.302      P=0.331      P=0.256    |
|COCHRAN-ARMITAGE       |  P=0.130                                           |  P=0.199                                           |
|FISHER EXACT           |               P=0.510N     P=0.228      P=0.237    |               P=0.341      P=0.329      P=0.221    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    4/79 (5%)    2/79 (3%)    2/80 (3%)  |  4/80 (5%)    1/80 (1%)    2/78 (3%)    1/80 (1%)  |
|ADJUSTED (b)           |   2.3%         9.3%         4.4%         4.8%      |   9.2%         2.6%         4.6%         2.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    4/43 (9%)    1/44 (2%)    2/42 (5%)  |  3/41 (7%)    1/38 (3%)    1/42 (2%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      736 (T)      718          736 (T)   |   538          736 (T)      723          551       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.567      P=0.180      P=0.511      P=0.492    |  P=0.148N     P=0.200N     P=0.329N     P=0.164N   |
|INCIDENTAL TUMOR       |  P=0.579N     P=0.180      P=0.624      P=0.492    |  P=0.213N     P=0.226N     P=0.537N     P=0.155N   |
|LOGISTIC REGRESSION    |  P=0.578      P=0.178      P=0.512      P=0.492    |  P=0.165N     P=0.187N     P=0.342N     P=0.211N   |
|COCHRAN-ARMITAGE       |  P=0.575                                           |  P=0.171N                                          |
|FISHER EXACT           |               P=0.180      P=0.495      P=0.500    |               P=0.184N     P=0.353N     P=0.184N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/80 (11%)  11/79 (14%)  14/79 (18%)  13/80 (16%) |  5/80 (6%)    5/80 (6%)    6/78 (8%)    6/80 (8%)  |
|ADJUSTED (b)           |  18.9%        25.6%        29.5%        29.8%      |  11.6%        13.2%        13.1%        12.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/9 (0%)   |
|TERMINAL (d)           |  6/43 (14%)  11/43 (26%)  11/44 (25%)  12/42 (29%) |  4/41 (10%)   5/38 (13%)   4/42 (10%)   5/45 (11%) |
|FIRST INCIDENCE (DAYS) |   460 (I)      736 (T)      460 (I)      460 (I)   |   538          736 (T)      461 (I)      551       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.181      P=0.403      P=0.199      P=0.225    |  P=0.487      P=0.587      P=0.515      P=0.556    |
|INCIDENTAL TUMOR       |  P=0.161      P=0.218      P=0.195      P=0.136    |  P=0.416      P=0.561      P=0.352      P=0.554    |
|LOGISTIC REGRESSION    |  P=0.195      P=0.411      P=0.187      P=0.240    |  P=0.431      P=0.609      P=0.491      P=0.513    |
|COCHRAN-ARMITAGE       |  P=0.207                                           |  P=0.409                                           |
|FISHER EXACT           |               P=0.394      P=0.175      P=0.246    |               P=0.627N     P=0.482      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/78 (0%)    0/80 (0%)    1/77 (1%)    2/79 (3%)  |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%         2.4%         4.5%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |                                                    |  0/40 (0%)    0/38 (0%)    1/41 (2%)    2/44 (5%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.084        (e)        P=0.505      P=0.260    |
|INCIDENTAL TUMOR       |                                                    |  P=0.084        (e)        P=0.505      P=0.260    |
|LOGISTIC REGRESSION    |                                                    |  P=0.084        (e)        P=0.505      P=0.260    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.070                                           |
|FISHER EXACT           |                                                    |                 (e)        P=0.497      P=0.252    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/78 (0%)    0/79 (0%)    0/74 (0%)    0/74 (0%)  |  6/76 (8%)    8/76 (11%)   6/76 (8%)    9/79 (11%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  15.4%        21.2%        15.0%        20.5%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/41 (0%)    0/43 (0%)    0/41 (0%)    0/39 (0%)  |  5/37 (14%)   6/34 (18%)   6/40 (15%)   9/44 (20%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   677          561          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.447      P=0.336      P=0.571N     P=0.413    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.389      P=0.427      P=0.600N     P=0.338    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.388      P=0.358      P=0.578N     P=0.377    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.320                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.390      P=0.618N     P=0.322    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/78 (0%)    0/79 (0%)    0/74 (0%)    0/74 (0%)  |  0/76 (0%)    1/76 (1%)    0/76 (0%)    2/79 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         2.2%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/9 (0%)     0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/41 (0%)    0/43 (0%)    0/41 (0%)    0/39 (0%)  |  0/37 (0%)    0/34 (0%)    0/40 (0%)    2/44 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          645          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.170      P=0.496        (e)        P=0.277    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.090      P=0.567        (e)        P=0.277    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.160      P=0.497        (e)        P=0.277    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.149                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500        (e)        P=0.258    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    1/79 (1%)    0/79 (0%)    0/80 (0%)  |  2/80 (3%)    2/80 (3%)    1/78 (1%)    1/80 (1%)  |
|ADJUSTED (b)           |   0.0%         2.3%         0.0%         0.0%      |   4.6%         4.9%         2.4%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    1/43 (2%)    0/44 (0%)    0/42 (0%)  |  1/41 (2%)    1/38 (3%)    1/42 (2%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          736 (T)      ---          ---       |   677          677          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.562N     P=0.500        (e)          (e)      |  P=0.307N     P=0.667      P=0.497N     P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.562N     P=0.500        (e)          (e)      |  P=0.451N     P=0.650N     P=0.553N     P=0.641N   |
|LOGISTIC REGRESSION    |  P=0.562N     P=0.500        (e)          (e)      |  P=0.323N     P=0.685      P=0.501N     P=0.491N   |
|COCHRAN-ARMITAGE       |  P=0.558N                                          |  P=0.338N                                          |
|FISHER EXACT           |               P=0.497        (e)          (e)      |               P=0.690N     P=0.510N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    1/79 (1%)    0/79 (0%)    0/80 (0%)  |  2/80 (3%)    1/80 (1%)    1/78 (1%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         2.3%         0.0%         0.0%      |   4.6%         2.4%         2.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    1/43 (2%)    0/44 (0%)    0/42 (0%)  |  1/41 (2%)    0/38 (0%)    1/42 (2%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          736 (T)      ---          ---       |   677          677          736 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.562N     P=0.500        (e)          (e)      |  P=0.144N     P=0.525N     P=0.497N     P=0.227N   |
|INCIDENTAL TUMOR       |  P=0.562N     P=0.500        (e)          (e)      |  P=0.247N     P=0.430N     P=0.553N     P=0.380N   |
|LOGISTIC REGRESSION    |  P=0.562N     P=0.500        (e)          (e)      |  P=0.150N     P=0.509N     P=0.501N     P=0.233N   |
|COCHRAN-ARMITAGE       |  P=0.558N                                          |  P=0.156N                                          |
|FISHER EXACT           |               P=0.497        (e)          (e)      |               P=0.500N     P=0.510N     P=0.248N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    1/79 (1%)    0/79 (0%)    0/80 (0%)  |  2/80 (3%)    2/80 (3%)    1/78 (1%)    1/80 (1%)  |
|ADJUSTED (b)           |   0.0%         2.3%         0.0%         0.0%      |   4.6%         4.9%         2.4%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    1/43 (2%)    0/44 (0%)    0/42 (0%)  |  1/41 (2%)    1/38 (3%)    1/42 (2%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          736 (T)      ---          ---       |   677          677          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.562N     P=0.500        (e)          (e)      |  P=0.307N     P=0.667      P=0.497N     P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.562N     P=0.500        (e)          (e)      |  P=0.451N     P=0.650N     P=0.553N     P=0.641N   |
|LOGISTIC REGRESSION    |  P=0.562N     P=0.500        (e)          (e)      |  P=0.323N     P=0.685      P=0.501N     P=0.491N   |
|COCHRAN-ARMITAGE       |  P=0.558N                                          |  P=0.338N                                          |
|FISHER EXACT           |               P=0.497        (e)          (e)      |               P=0.690N     P=0.510N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/80 (5%)    1/79 (1%)    1/79 (1%)    1/79 (1%)  |  3/80 (4%)    1/80 (1%)    1/78 (1%)    1/80 (1%)  |
|ADJUSTED (b)           |   9.3%         2.3%         2.3%         2.4%      |   7.3%         2.3%         2.4%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  4/43 (9%)    1/43 (2%)    1/44 (2%)    1/42 (2%)  |  3/41 (7%)    0/38 (0%)    1/42 (2%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      736 (T)      736 (T)      736 (T)   |   736 (T)      652          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.140N     P=0.180N     P=0.173N     P=0.187N   |  P=0.218N     P=0.329N     P=0.297N     P=0.273N   |
|INCIDENTAL TUMOR       |  P=0.140N     P=0.180N     P=0.173N     P=0.187N   |  P=0.270N     P=0.297N     P=0.297N     P=0.273N   |
|LOGISTIC REGRESSION    |  P=0.140N     P=0.178N     P=0.173N     P=0.185N   |  P=0.232N     P=0.317N     P=0.297N     P=0.273N   |
|COCHRAN-ARMITAGE       |  P=0.141N                                          |  P=0.247N                                          |
|FISHER EXACT           |               P=0.187N     P=0.187N     P=0.187N   |               P=0.310N     P=0.320N     P=0.310N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    0/79 (0%)    2/79 (3%)    0/80 (0%)  |  0/80 (0%)    1/80 (1%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         4.5%         0.0%      |   0.0%         2.4%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    0/43 (0%)    2/44 (5%)    0/42 (0%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      ---          736 (T)      ---       |   ---          677          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.471N     P=0.500N     P=0.508      P=0.505N   |  P=0.552N     P=0.486        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.471N     P=0.500N     P=0.508      P=0.505N   |  P=0.813N     P=0.567        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.471N     P=0.500N     P=0.508      P=0.505N   |  P=0.556N     P=0.496        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.465N                                          |  P=0.559N                                          |
|FISHER EXACT           |               P=0.503N     P=0.495      P=0.500N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    0/79 (0%)    2/79 (3%)    0/80 (0%)  |  0/80 (0%)    1/80 (1%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         0.0%      |   0.0%         2.4%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    0/43 (0%)    2/44 (5%)    0/42 (0%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          736 (T)      ---       |   ---          677          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.587        (e)        P=0.244        (e)      |  P=0.552N     P=0.486        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.587        (e)        P=0.244        (e)      |  P=0.813N     P=0.567        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.587        (e)        P=0.244        (e)      |  P=0.556N     P=0.496        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.591                                           |  P=0.559N                                          |
|FISHER EXACT           |                 (e)        P=0.245        (e)      |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    0/79 (0%)    2/79 (3%)    1/80 (1%)  |  1/79 (1%)    0/80 (0%)    1/78 (1%)    0/80 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         2.4%      |   2.0%         0.0%         2.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    0/43 (0%)    2/44 (5%)    1/42 (2%)  |  0/41 (0%)    0/38 (0%)    1/42 (2%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          736 (T)      736 (T)   |   523          ---          736 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.237        (e)        P=0.244      P=0.495    |  P=0.398N     P=0.504N     P=0.758      P=0.500N   |
|INCIDENTAL TUMOR       |  P=0.237        (e)        P=0.244      P=0.495    |  P=0.539N     P=0.581N     P=0.505      P=0.718N   |
|LOGISTIC REGRESSION    |  P=0.237        (e)        P=0.244      P=0.495    |  P=0.406N     P=0.497N     P=0.760      P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.244                                           |  P=0.408N                                          |
|FISHER EXACT           |                 (e)        P=0.245      P=0.500    |               P=0.497N     P=0.748      P=0.497N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Odontoma                                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/80 (3%)    2/79 (3%)    2/79 (3%)    1/80 (1%)  |  0/80 (0%)    0/80 (0%)    0/78 (0%)    0/80 (0%)  |
|ADJUSTED (b)           |   4.7%         4.7%         4.5%         2.4%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  2/43 (5%)    2/43 (5%)    2/44 (5%)    1/42 (2%)  |  0/41 (0%)    0/38 (0%)    0/42 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      736 (T)      736 (T)      736 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.379N     P=0.695      P=0.686N     P=0.508N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.379N     P=0.695      P=0.686N     P=0.508N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.379N     P=0.695      P=0.686N     P=0.508N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.372N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.685      P=0.685      P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/80 (3%)    1/80 (1%)    3/78 (4%)    0/80 (0%)  |
|ADJUSTED (b)           |                                                    |   4.9%         2.6%         7.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |                                                    |  2/41 (5%)    1/38 (3%)    3/42 (7%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   736 (T)      736 (T)      736 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.213N     P=0.527N     P=0.511      P=0.218N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.213N     P=0.527N     P=0.511      P=0.218N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.213N     P=0.527N     P=0.511      P=0.218N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.247N                                          |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.488      P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/80 (1%)    0/79 (0%)    0/79 (0%)    0/80 (0%)  |  0/80 (0%)    0/80 (0%)    4/78 (5%)    0/80 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         0.0%         0.0%      |   0.0%         0.0%         9.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  1/43 (2%)    0/43 (0%)    0/44 (0%)    0/42 (0%)  |  0/41 (0%)    0/38 (0%)    4/42 (10%)   0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      ---          ---          ---       |   ---          ---          736 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.311N     P=0.500N     P=0.495N     P=0.505N   |  P=0.532        (e)        P=0.066        (e)      |
|INCIDENTAL TUMOR       |  P=0.311N     P=0.500N     P=0.495N     P=0.505N   |  P=0.532        (e)        P=0.066        (e)      |
|LOGISTIC REGRESSION    |  P=0.311N     P=0.500N     P=0.495N     P=0.505N   |  P=0.532        (e)        P=0.066        (e)      |
|COCHRAN-ARMITAGE       |  P=0.309N                                          |  P=0.494                                           |
|FISHER EXACT           |               P=0.503N     P=0.503N     P=0.500N   |                 (e)        P=0.057        (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/80 (6%)    2/79 (3%)    4/79 (5%)    2/80 (3%)  |  4/80 (5%)    1/80 (1%)    1/78 (1%)    1/80 (1%)  |
|ADJUSTED (b)           |  11.6%         4.7%         8.4%         4.7%      |   9.8%         2.3%         2.4%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  5/43 (12%)   2/43 (5%)    3/44 (7%)    1/42 (2%)  |  4/41 (10%)   0/38 (0%)    1/42 (2%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      736 (T)      460 (I)      731       |   736 (T)      652          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.245N     P=0.216N     P=0.487N     P=0.227N   |  P=0.119N     P=0.202N     P=0.172N     P=0.153N   |
|INCIDENTAL TUMOR       |  P=0.220N     P=0.216N     P=0.487N     P=0.156N   |  P=0.149N     P=0.179N     P=0.172N     P=0.153N   |
|LOGISTIC REGRESSION    |  P=0.236N     P=0.216N     P=0.488N     P=0.212N   |  P=0.128N     P=0.191N     P=0.172N     P=0.153N   |
|COCHRAN-ARMITAGE       |  P=0.239N                                          |  P=0.140N                                          |
|FISHER EXACT           |               P=0.226N     P=0.508N     P=0.221N   |               P=0.184N     P=0.191N     P=0.184N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/80 (8%)    2/79 (3%)    4/79 (5%)    2/80 (3%)  |  4/80 (5%)    1/80 (1%)    5/78 (6%)    1/80 (1%)  |
|ADJUSTED (b)           |  14.0%         4.7%         8.4%         4.7%      |   9.8%         2.3%        11.9%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  6/43 (14%)   2/43 (5%)    3/44 (7%)    1/42 (2%)  |  4/41 (10%)   0/38 (0%)    5/42 (12%)   1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   736 (T)      736 (T)      460 (I)      731       |   736 (T)      652          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.162N     P=0.134N     P=0.358N     P=0.143N   |  P=0.212N     P=0.202N     P=0.515      P=0.153N   |
|INCIDENTAL TUMOR       |  P=0.143N     P=0.134N     P=0.358N     P=0.094N   |  P=0.252N     P=0.179N     P=0.515      P=0.153N   |
|LOGISTIC REGRESSION    |  P=0.153N     P=0.134N     P=0.357N     P=0.130N   |  P=0.231N     P=0.191N     P=0.515      P=0.153N   |
|COCHRAN-ARMITAGE       |  P=0.158N                                          |  P=0.257N                                          |
|FISHER EXACT           |               P=0.142N     P=0.381N     P=0.138N   |               P=0.184N     P=0.484      P=0.184N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/80 (0%)    2/79 (3%)    0/79 (0%)    2/80 (3%)  |  1/80 (1%)    3/80 (4%)    2/78 (3%)    1/80 (1%)  |
|ADJUSTED (b)           |   0.0%         3.9%         0.0%         4.4%      |   2.4%         6.6%         4.6%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/43 (0%)    0/43 (0%)    0/44 (0%)    0/42 (0%)  |  1/41 (2%)    0/38 (0%)    1/42 (2%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          397          ---          682       |   736 (T)      571          653          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.257      P=0.242        (e)        P=0.245    |  P=0.441N     P=0.296      P=0.506      P=0.741N   |
|INCIDENTAL TUMOR       |  P=0.503      P=0.773        (e)        P=0.581    |  P=0.591      P=0.457      P=0.447      P=0.741N   |
|LOGISTIC REGRESSION    |  P=0.254      P=0.236        (e)        P=0.239    |  P=0.580      P=0.301      P=0.498      P=0.741N   |
|COCHRAN-ARMITAGE       |  P=0.254                                           |  P=0.470N                                          |
|FISHER EXACT           |               P=0.245        (e)        P=0.248    |               P=0.310      P=0.490      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/80 (4%)    3/79 (4%)    2/79 (3%)    2/80 (3%)  |  4/80 (5%)    6/80 (8%)    6/78 (8%)    6/80 (8%)  |
|ADJUSTED (b)           |   6.7%         7.0%         4.5%         4.8%      |   9.5%        15.4%        13.8%        13.3%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  2/43 (5%)    3/43 (7%)    2/44 (5%)    2/42 (5%)  |  3/41 (7%)    5/38 (13%)   5/42 (12%)   6/45 (13%) |
|FIRST INCIDENCE (DAYS) |   603          736 (T)      736 (T)      736 (T)   |   698          700          607          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.379N     P=0.661      P=0.492N     P=0.510N   |  P=0.440      P=0.324      P=0.386      P=0.428    |
|INCIDENTAL TUMOR       |  P=0.441N     P=0.500      P=0.570N     P=0.633N   |  P=0.369      P=0.373      P=0.393      P=0.336    |
|LOGISTIC REGRESSION    |  P=0.368N     P=0.657N     P=0.490N     P=0.498N   |  P=0.392      P=0.338      P=0.369      P=0.399    |
|COCHRAN-ARMITAGE       |  P=0.370N                                          |  P=0.354                                           |
|FISHER EXACT           |               P=0.653      P=0.506N     P=0.500N   |               P=0.373      P=0.357      P=0.373    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  18
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/80 (41%)  24/79 (30%)  35/79 (44%)  35/80 (44%) | 28/80 (35%)  31/80 (39%)  25/78 (32%)  32/80 (40%) |
|ADJUSTED (b)           |  61.3%        52.7%        71.1%        72.4%      |  61.8%        68.2%        56.5%        66.5%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  5/10 (50%)   1/10 (10%)   3/10 (30%)   3/10 (30%) |  1/10 (10%)   2/10 (20%)   1/10 (10%)   1/9 (11%)  |
|TERMINAL (d)           | 23/43 (53%)  22/43 (51%)  30/44 (68%)  29/42 (69%) | 24/41 (59%)  24/38 (63%)  23/42 (55%)  29/45 (64%) |
|FIRST INCIDENCE (DAYS) |   281 (I)      281 (I)      460 (I)      460 (I)   |   461 (I)      461 (I)      461 (I)      461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.143      P=0.078N     P=0.477      P=0.390    |  P=0.501N     P=0.237      P=0.311N     P=0.456    |
|INCIDENTAL TUMOR       |  P=0.099      P=0.176N     P=0.385      P=0.309    |  P=0.476      P=0.359      P=0.344N     P=0.384    |
|LOGISTIC REGRESSION    |  P=0.167      P=0.074N     P=0.453      P=0.429    |  P=0.382      P=0.303      P=0.362N     P=0.316    |
|COCHRAN-ARMITAGE       |  P=0.202                                           |  P=0.345                                           |
|FISHER EXACT           |               P=0.103N     P=0.410      P=0.437    |               P=0.372      P=0.412N     P=0.312    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/80 (28%)  23/79 (29%)  17/79 (22%)  21/80 (26%) | 22/80 (28%)  16/80 (20%)  15/78 (19%)  19/80 (24%) |
|ADJUSTED (b)           |  47.7%        46.5%        35.2%        45.7%      |  47.7%        35.1%        32.5%        38.7%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  0/10 (0%)    1/10 (10%)   1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           | 19/43 (44%)  17/43 (40%)  13/44 (30%)  17/42 (40%) | 17/41 (41%)   9/38 (24%)  11/42 (26%)  15/45 (33%) |
|FIRST INCIDENCE (DAYS) |   553          397          460 (I)      676       |   538          561          607          471       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.409N     P=0.505      P=0.198N     P=0.531N   |  P=0.264N     P=0.244N     P=0.114N     P=0.250N   |
|INCIDENTAL TUMOR       |  P=0.240N     P=0.467N     P=0.124N     P=0.395N   |  P=0.536      P=0.089N     P=0.164N     P=0.487N   |
|LOGISTIC REGRESSION    |  P=0.371N     P=0.512      P=0.183N     P=0.489N   |  P=0.533      P=0.072N     P=0.145N     P=0.412N   |
|COCHRAN-ARMITAGE       |  P=0.383N                                          |  P=0.400N                                          |
|FISHER EXACT           |               P=0.480      P=0.245N     P=0.500N   |               P=0.177N     P=0.149N     P=0.359N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05100 TEST: 04                                                 PAGE  19
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE

                                                 TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        60 PPM       125 PPM      250 PPM   |   0 PPM        60 PPM       125 PPM      250 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 44/80 (55%)  38/79 (48%)  42/79 (53%)  42/80 (53%) | 41/80 (51%)  41/80 (51%)  33/78 (42%)  42/80 (53%) |
|ADJUSTED (b)           |  79.6%        74.1%        82.2%        82.2%      |  81.8%        83.5%        70.0%        83.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 2 (c)|  2/10 (20%)   1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|INTERIM SACRIFICE 3 (c)|  5/10 (50%)   2/10 (20%)   3/10 (30%)   3/10 (30%) |  1/10 (10%)   2/10 (20%)   1/10 (10%)   1/9 (11%)  |
|TERMINAL (d)           | 32/43 (74%)  30/43 (70%)  35/44 (80%)  33/42 (79%) | 32/41 (78%)  30/38 (79%)  28/42 (67%)  37/45 (82%) |
|FIRST INCIDENCE (DAYS) |   281 (I)      281 (I)      460 (I)      460 (I)   |   425          461 (I)      461 (I)      461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.495      P=0.194N     P=0.367N     P=0.483N   |  P=0.245N     P=0.389      P=0.082N     P=0.405N   |
|INCIDENTAL TUMOR       |  P=0.493N     P=0.143N     P=0.370N     P=0.425N   |  P=0.511      P=0.526N     P=0.174N     P=0.430    |
|LOGISTIC REGRESSION    |  P=0.520N     P=0.170N     P=0.384N     P=0.420N   |  P=0.490      P=0.589      P=0.132N     P=0.542    |
|COCHRAN-ARMITAGE       |  P=0.511N                                          |  P=0.517                                           |
|FISHER EXACT           |               P=0.238N     P=0.471N     P=0.437N   |               P=0.563N     P=0.167N     P=0.500    |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   90  281  460
          Female interim sacrifices(days): 90  282  461
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).