TDMS Study 05100-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 04 TIME: 16:08:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B
PATHOLOGIST: A. SINGER CAS: 1330-78-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 04 TIME: 16:08:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B
PATHOLOGIST: A. SINGER CAS: 1330-78-5
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 04 TIME: 16:08:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B
PATHOLOGIST: A. SINGER CAS: 1330-78-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TRICRESYL PHOSPHATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Intestine Small: Jejunum Carcinoma
Intestine Small: Site Unspecified
Carcinoma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Carcinoma
====================================================================================================
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/80 (4%) 3/79 (4%) 2/79 (3%) 3/80 (4%) | 4/80 (5%) 0/79 (0%) 0/78 (0%) 1/80 (1%) |
|ADJUSTED (b) | 6.3% 7.0% 3.9% 6.4% | 8.9% 0.0% 0.0% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/43 (5%) 3/43 (7%) 1/44 (2%) 2/42 (5%) | 3/41 (7%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 460 (I) 736 (T) 460 (I) 460 (I) | 461 (I) --- --- 555 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.569N P=0.661 P=0.494N P=0.654 | P=0.123N P=0.072N P=0.063N P=0.172N |
|INCIDENTAL TUMOR | P=0.569N P=0.661 P=0.494N P=0.654 | P=0.102N P=0.072N P=0.063N P=0.116N |
|LOGISTIC REGRESSION | P=0.560N P=0.660N P=0.500N P=0.662N | P=0.129N P=0.068N P=0.066N P=0.180N |
|COCHRAN-ARMITAGE | P=0.559N | P=0.131N |
|FISHER EXACT | P=0.653 P=0.506N P=0.659N | P=0.062N P=0.063N P=0.184N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/79 (3%) 0/79 (0%) 0/79 (0%) 0/78 (0%) | 2/80 (3%) 0/79 (0%) 1/78 (1%) 0/78 (0%) |
|ADJUSTED (b) | 4.7% 0.0% 0.0% 0.0% | 4.9% 0.0% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 2/43 (5%) 0/43 (0%) 0/44 (0%) 0/41 (0%) | 2/41 (5%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- --- --- | 736 (T) --- 621 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.238N P=0.233N P=0.249N | P=0.181N P=0.255N P=0.494N P=0.218N |
|INCIDENTAL TUMOR | P=0.120N P=0.238N P=0.233N P=0.249N | P=0.146N P=0.255N P=0.416N P=0.218N |
|LOGISTIC REGRESSION | P=0.120N P=0.238N P=0.233N P=0.249N | P=0.190N P=0.255N P=0.504N P=0.218N |
|COCHRAN-ARMITAGE | P=0.119N | P=0.197N |
|FISHER EXACT | P=0.248N P=0.248N P=0.252N | P=0.252N P=0.510N P=0.255N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 2/79 (3%) 2/79 (3%) 5/80 (6%) | 5/80 (6%) 3/80 (4%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 4.0% 4.5% 11.9% | 12.2% 7.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 1/43 (2%) 2/44 (5%) 5/42 (12%) | 5/41 (12%) 2/38 (5%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- 460 (I) 736 (T) 736 (T) | 736 (T) 603 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * P=0.240 P=0.244 P=0.031 * | P=0.006N** P=0.394N P=0.031N* P=0.026N* |
|INCIDENTAL TUMOR | P=0.016 * P=0.240 P=0.244 P=0.031 * | P=0.005N** P=0.323N P=0.031N* P=0.026N* |
|LOGISTIC REGRESSION | P=0.017 * P=0.237 P=0.244 P=0.031 * | P=0.007N** P=0.377N P=0.031N* P=0.026N* |
|COCHRAN-ARMITAGE | P=0.018 * | P=0.008N** |
|FISHER EXACT | P=0.245 P=0.245 P=0.029 * | P=0.360N P=0.031N* P=0.029N* |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 1/79 (1%) 2/79 (3%) 0/80 (0%) | 0/80 (0%) 0/80 (0%) 1/78 (1%) 0/80 (0%) |
|ADJUSTED (b) | 2.3% 2.3% 4.5% 0.0% | 0.0% 0.0% 2.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 1/43 (2%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) --- | --- --- 723 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372N P=0.762 P=0.508 P=0.505N | P=0.706 (e) P=0.514 (e) |
|INCIDENTAL TUMOR | P=0.372N P=0.762 P=0.508 P=0.505N | P=0.517 (e) P=0.398 (e) |
|LOGISTIC REGRESSION | P=0.372N P=0.762 P=0.508 P=0.505N | P=0.696 (e) P=0.501 (e) |
|COCHRAN-ARMITAGE | P=0.367N | P=0.690 |
|FISHER EXACT | P=0.748 P=0.495 P=0.500N | (e) P=0.494 (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 3/79 (4%) 3/79 (4%) 5/80 (6%) | 5/80 (6%) 3/80 (4%) 1/78 (1%) 0/80 (0%) |
|ADJUSTED (b) | 2.3% 6.3% 6.8% 11.9% | 12.2% 7.3% 2.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 2/43 (5%) 3/44 (7%) 5/42 (12%) | 5/41 (12%) 2/38 (5%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 460 (I) 736 (T) 736 (T) | 736 (T) 603 723 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076 P=0.307 P=0.314 P=0.098 | P=0.010N* P=0.394N P=0.098N P=0.026N* |
|INCIDENTAL TUMOR | P=0.076 P=0.307 P=0.314 P=0.098 | P=0.011N* P=0.323N P=0.119N P=0.026N* |
|LOGISTIC REGRESSION | P=0.081 P=0.306 P=0.314 P=0.098 | P=0.011N* P=0.377N P=0.098N P=0.026N* |
|COCHRAN-ARMITAGE | P=0.084 | P=0.013N* |
|FISHER EXACT | P=0.305 P=0.305 P=0.105 | P=0.360N P=0.111N P=0.029N* |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 0/79 (0%) 0/79 (0%) 2/80 (3%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 4.8% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/43 (0%) 0/44 (0%) 2/42 (5%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 736 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.047 * | (e) |
|FISHER EXACT | (e) (e) P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 0/79 (0%) 0/79 (0%) 2/80 (3%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 4.8% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/43 (0%) 0/44 (0%) 2/42 (5%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 736 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.044 * (e) (e) P=0.233 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.047 * | (e) |
|FISHER EXACT | (e) (e) P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 0/79 (0%) 3/79 (4%) 2/80 (3%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 6.5% 4.8% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 0/43 (0%) 2/44 (5%) 2/42 (5%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 583 736 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231 P=0.500N P=0.315 P=0.492 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.172 P=0.500N P=0.236 P=0.492 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.238 P=0.500N P=0.312 P=0.492 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.240 | (e) |
|FISHER EXACT | P=0.503N P=0.305 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 0/79 (0%) 3/79 (4%) 2/80 (3%) | 1/80 (1%) 0/80 (0%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 6.5% 4.8% | 2.4% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 0/43 (0%) 2/44 (5%) 2/42 (5%) | 1/41 (2%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 583 736 (T) | 736 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231 P=0.500N P=0.315 P=0.492 | P=0.296N P=0.515N P=0.495N P=0.481N |
|INCIDENTAL TUMOR | P=0.172 P=0.500N P=0.236 P=0.492 | P=0.296N P=0.515N P=0.495N P=0.481N |
|LOGISTIC REGRESSION | P=0.238 P=0.500N P=0.312 P=0.492 | P=0.296N P=0.515N P=0.495N P=0.481N |
|COCHRAN-ARMITAGE | P=0.240 | P=0.310N |
|FISHER EXACT | P=0.503N P=0.305 P=0.500 | P=0.500N P=0.506N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 0/79 (0%) 3/79 (4%) 0/80 (0%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.2% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/43 (0%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 460 (I) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.531 (e) P=0.126 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.531 (e) P=0.126 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.535 (e) P=0.122 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.535 | (e) |
|FISHER EXACT | (e) P=0.120 (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/80 (29%) 19/79 (24%) 19/79 (24%) 20/80 (25%) | 13/80 (16%) 13/80 (16%) 13/78 (17%) 16/80 (20%) |
|ADJUSTED (b) | 44.6% 42.7% 40.7% 42.7% | 29.6% 30.5% 31.0% 33.8% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 3/10 (30%) 0/10 (0%) 2/10 (20%) 2/10 (20%) | 1/10 (10%) 2/10 (20%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 16/43 (37%) 18/43 (42%) 17/44 (39%) 16/42 (38%) | 11/41 (27%) 10/38 (26%) 13/42 (31%) 14/45 (31%) |
|FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 736 (T) 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.393N P=0.286N P=0.262N P=0.383N | P=0.395 P=0.517 P=0.564N P=0.424 |
|INCIDENTAL TUMOR | P=0.405N P=0.423N P=0.317N P=0.359N | P=0.349 P=0.577 P=0.534N P=0.405 |
|LOGISTIC REGRESSION | P=0.363N P=0.282N P=0.271N P=0.352N | P=0.306 P=0.563 P=0.587 P=0.356 |
|COCHRAN-ARMITAGE | P=0.370N | P=0.279 |
|FISHER EXACT | P=0.312N P=0.312N P=0.361N | P=0.585N P=0.557 P=0.341 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/80 (19%) 13/79 (16%) 10/79 (13%) 15/80 (19%) | 10/80 (13%) 3/80 (4%) 1/78 (1%) 6/80 (8%) |
|ADJUSTED (b) | 32.5% 27.2% 21.3% 34.0% | 22.9% 7.2% 2.2% 12.7% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 12/43 (28%) 9/43 (21%) 7/44 (16%) 13/42 (31%) | 8/41 (20%) 2/38 (5%) 0/42 (0%) 4/45 (9%) |
|FIRST INCIDENCE (DAYS) | 553 460 (I) 667 676 | 538 561 621 555 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.511 P=0.413N P=0.174N P=0.559 | P=0.179N P=0.051N P=0.006N** P=0.170N |
|INCIDENTAL TUMOR | P=0.463N P=0.336N P=0.093N P=0.574N | P=0.217N P=0.036N* P=0.009N** P=0.267N |
|LOGISTIC REGRESSION | P=0.508 P=0.535N P=0.162N P=0.579N | P=0.293N P=0.042N* P=0.006N** P=0.260N |
|COCHRAN-ARMITAGE | P=0.533 | P=0.224N |
|FISHER EXACT | P=0.432N P=0.201N P=0.580N | P=0.040N* P=0.005N** P=0.215N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/80 (41%) 28/79 (35%) 26/79 (33%) 30/80 (38%) | 22/80 (28%) 16/80 (20%) 14/78 (18%) 19/80 (24%) |
|ADJUSTED (b) | 62.7% 57.8% 52.7% 63.4% | 48.3% 36.8% 32.5% 39.3% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 3/10 (30%) 1/10 (10%) 2/10 (20%) 2/10 (20%) | 1/10 (10%) 2/10 (20%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 24/43 (56%) 23/43 (53%) 21/44 (48%) 25/42 (60%) | 18/41 (44%) 12/38 (32%) 13/42 (31%) 16/45 (36%) |
|FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 621 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.413N P=0.244N P=0.131N P=0.402N | P=0.249N P=0.227N P=0.069N P=0.250N |
|INCIDENTAL TUMOR | P=0.323N P=0.239N P=0.091N P=0.339N | P=0.290N P=0.160N P=0.076N P=0.300N |
|LOGISTIC REGRESSION | P=0.367N P=0.232N P=0.122N P=0.354N | P=0.341N P=0.179N P=0.078N P=0.320N |
|COCHRAN-ARMITAGE | P=0.381N | P=0.391N |
|FISHER EXACT | P=0.278N P=0.178N P=0.373N | P=0.177N P=0.107N P=0.359N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/80 (41%) 28/79 (35%) 26/79 (33%) 30/80 (38%) | 22/80 (28%) 16/80 (20%) 14/78 (18%) 19/80 (24%) |
|ADJUSTED (b) | 62.7% 57.8% 52.7% 63.4% | 48.3% 36.8% 32.5% 39.3% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 3/10 (30%) 1/10 (10%) 2/10 (20%) 2/10 (20%) | 1/10 (10%) 2/10 (20%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 24/43 (56%) 23/43 (53%) 21/44 (48%) 25/42 (60%) | 18/41 (44%) 12/38 (32%) 13/42 (31%) 16/45 (36%) |
|FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 621 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.413N P=0.244N P=0.131N P=0.402N | P=0.249N P=0.227N P=0.069N P=0.250N |
|INCIDENTAL TUMOR | P=0.323N P=0.239N P=0.091N P=0.339N | P=0.290N P=0.160N P=0.076N P=0.300N |
|LOGISTIC REGRESSION | P=0.367N P=0.232N P=0.122N P=0.354N | P=0.341N P=0.179N P=0.078N P=0.320N |
|COCHRAN-ARMITAGE | P=0.381N | P=0.391N |
|FISHER EXACT | P=0.278N P=0.178N P=0.373N | P=0.177N P=0.107N P=0.359N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/80 (10%) 7/79 (9%) 12/79 (15%) 12/80 (15%) | 2/80 (3%) 4/80 (5%) 4/78 (5%) 5/80 (6%) |
|ADJUSTED (b) | 16.7% 16.3% 25.7% 27.4% | 4.9% 10.5% 8.8% 11.1% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) |
|TERMINAL (d) | 5/43 (12%) 7/43 (16%) 10/44 (23%) 11/42 (26%) | 2/41 (5%) 4/38 (11%) 3/42 (7%) 5/45 (11%) |
|FIRST INCIDENCE (DAYS) | 460 (I) 736 (T) 460 (I) 460 (I) | 736 (T) 736 (T) 461 (I) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112 P=0.501N P=0.252 P=0.218 | P=0.249 P=0.302 P=0.348 P=0.256 |
|INCIDENTAL TUMOR | P=0.088 P=0.500 P=0.217 P=0.129 | P=0.249 P=0.302 P=0.348 P=0.256 |
|LOGISTIC REGRESSION | P=0.121 P=0.494N P=0.242 P=0.232 | P=0.215 P=0.302 P=0.331 P=0.256 |
|COCHRAN-ARMITAGE | P=0.130 | P=0.199 |
|FISHER EXACT | P=0.510N P=0.228 P=0.237 | P=0.341 P=0.329 P=0.221 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 4/79 (5%) 2/79 (3%) 2/80 (3%) | 4/80 (5%) 1/80 (1%) 2/78 (3%) 1/80 (1%) |
|ADJUSTED (b) | 2.3% 9.3% 4.4% 4.8% | 9.2% 2.6% 4.6% 2.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 4/43 (9%) 1/44 (2%) 2/42 (5%) | 3/41 (7%) 1/38 (3%) 1/42 (2%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 718 736 (T) | 538 736 (T) 723 551 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.567 P=0.180 P=0.511 P=0.492 | P=0.148N P=0.200N P=0.329N P=0.164N |
|INCIDENTAL TUMOR | P=0.579N P=0.180 P=0.624 P=0.492 | P=0.213N P=0.226N P=0.537N P=0.155N |
|LOGISTIC REGRESSION | P=0.578 P=0.178 P=0.512 P=0.492 | P=0.165N P=0.187N P=0.342N P=0.211N |
|COCHRAN-ARMITAGE | P=0.575 | P=0.171N |
|FISHER EXACT | P=0.180 P=0.495 P=0.500 | P=0.184N P=0.353N P=0.184N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/80 (11%) 11/79 (14%) 14/79 (18%) 13/80 (16%) | 5/80 (6%) 5/80 (6%) 6/78 (8%) 6/80 (8%) |
|ADJUSTED (b) | 18.9% 25.6% 29.5% 29.8% | 11.6% 13.2% 13.1% 12.9% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%) |
|TERMINAL (d) | 6/43 (14%) 11/43 (26%) 11/44 (25%) 12/42 (29%) | 4/41 (10%) 5/38 (13%) 4/42 (10%) 5/45 (11%) |
|FIRST INCIDENCE (DAYS) | 460 (I) 736 (T) 460 (I) 460 (I) | 538 736 (T) 461 (I) 551 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181 P=0.403 P=0.199 P=0.225 | P=0.487 P=0.587 P=0.515 P=0.556 |
|INCIDENTAL TUMOR | P=0.161 P=0.218 P=0.195 P=0.136 | P=0.416 P=0.561 P=0.352 P=0.554 |
|LOGISTIC REGRESSION | P=0.195 P=0.411 P=0.187 P=0.240 | P=0.431 P=0.609 P=0.491 P=0.513 |
|COCHRAN-ARMITAGE | P=0.207 | P=0.409 |
|FISHER EXACT | P=0.394 P=0.175 P=0.246 | P=0.627N P=0.482 P=0.500 |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/78 (0%) 0/80 (0%) 1/77 (1%) 2/79 (3%) |
|ADJUSTED (b) | | 0.0% 0.0% 2.4% 4.5% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 0/40 (0%) 0/38 (0%) 1/41 (2%) 2/44 (5%) |
|FIRST INCIDENCE (DAYS) | | --- --- 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.084 (e) P=0.505 P=0.260 |
|INCIDENTAL TUMOR | | P=0.084 (e) P=0.505 P=0.260 |
|LOGISTIC REGRESSION | | P=0.084 (e) P=0.505 P=0.260 |
|COCHRAN-ARMITAGE | | P=0.070 |
|FISHER EXACT | | (e) P=0.497 P=0.252 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/78 (0%) 0/79 (0%) 0/74 (0%) 0/74 (0%) | 6/76 (8%) 8/76 (11%) 6/76 (8%) 9/79 (11%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 15.4% 21.2% 15.0% 20.5% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/41 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 5/37 (14%) 6/34 (18%) 6/40 (15%) 9/44 (20%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 677 561 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.447 P=0.336 P=0.571N P=0.413 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.389 P=0.427 P=0.600N P=0.338 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.388 P=0.358 P=0.578N P=0.377 |
|COCHRAN-ARMITAGE | (e) | P=0.320 |
|FISHER EXACT | (e) (e) (e) | P=0.390 P=0.618N P=0.322 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/78 (0%) 0/79 (0%) 0/74 (0%) 0/74 (0%) | 0/76 (0%) 1/76 (1%) 0/76 (0%) 2/79 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 2.2% 0.0% 4.5% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/41 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 0/37 (0%) 0/34 (0%) 0/40 (0%) 2/44 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 645 --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.170 P=0.496 (e) P=0.277 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.090 P=0.567 (e) P=0.277 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.160 P=0.497 (e) P=0.277 |
|COCHRAN-ARMITAGE | (e) | P=0.149 |
|FISHER EXACT | (e) (e) (e) | P=0.500 (e) P=0.258 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 1/79 (1%) 0/79 (0%) 0/80 (0%) | 2/80 (3%) 2/80 (3%) 1/78 (1%) 1/80 (1%) |
|ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 4.6% 4.9% 2.4% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 1/43 (2%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 1/38 (3%) 1/42 (2%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | --- 736 (T) --- --- | 677 677 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562N P=0.500 (e) (e) | P=0.307N P=0.667 P=0.497N P=0.476N |
|INCIDENTAL TUMOR | P=0.562N P=0.500 (e) (e) | P=0.451N P=0.650N P=0.553N P=0.641N |
|LOGISTIC REGRESSION | P=0.562N P=0.500 (e) (e) | P=0.323N P=0.685 P=0.501N P=0.491N |
|COCHRAN-ARMITAGE | P=0.558N | P=0.338N |
|FISHER EXACT | P=0.497 (e) (e) | P=0.690N P=0.510N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 1/79 (1%) 0/79 (0%) 0/80 (0%) | 2/80 (3%) 1/80 (1%) 1/78 (1%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 4.6% 2.4% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 1/43 (2%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 0/38 (0%) 1/42 (2%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- 736 (T) --- --- | 677 677 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562N P=0.500 (e) (e) | P=0.144N P=0.525N P=0.497N P=0.227N |
|INCIDENTAL TUMOR | P=0.562N P=0.500 (e) (e) | P=0.247N P=0.430N P=0.553N P=0.380N |
|LOGISTIC REGRESSION | P=0.562N P=0.500 (e) (e) | P=0.150N P=0.509N P=0.501N P=0.233N |
|COCHRAN-ARMITAGE | P=0.558N | P=0.156N |
|FISHER EXACT | P=0.497 (e) (e) | P=0.500N P=0.510N P=0.248N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 1/79 (1%) 0/79 (0%) 0/80 (0%) | 2/80 (3%) 2/80 (3%) 1/78 (1%) 1/80 (1%) |
|ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 4.6% 4.9% 2.4% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 1/43 (2%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 1/38 (3%) 1/42 (2%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | --- 736 (T) --- --- | 677 677 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562N P=0.500 (e) (e) | P=0.307N P=0.667 P=0.497N P=0.476N |
|INCIDENTAL TUMOR | P=0.562N P=0.500 (e) (e) | P=0.451N P=0.650N P=0.553N P=0.641N |
|LOGISTIC REGRESSION | P=0.562N P=0.500 (e) (e) | P=0.323N P=0.685 P=0.501N P=0.491N |
|COCHRAN-ARMITAGE | P=0.558N | P=0.338N |
|FISHER EXACT | P=0.497 (e) (e) | P=0.690N P=0.510N P=0.500N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/80 (5%) 1/79 (1%) 1/79 (1%) 1/79 (1%) | 3/80 (4%) 1/80 (1%) 1/78 (1%) 1/80 (1%) |
|ADJUSTED (b) | 9.3% 2.3% 2.3% 2.4% | 7.3% 2.3% 2.4% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 4/43 (9%) 1/43 (2%) 1/44 (2%) 1/42 (2%) | 3/41 (7%) 0/38 (0%) 1/42 (2%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) 736 (T) | 736 (T) 652 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140N P=0.180N P=0.173N P=0.187N | P=0.218N P=0.329N P=0.297N P=0.273N |
|INCIDENTAL TUMOR | P=0.140N P=0.180N P=0.173N P=0.187N | P=0.270N P=0.297N P=0.297N P=0.273N |
|LOGISTIC REGRESSION | P=0.140N P=0.178N P=0.173N P=0.185N | P=0.232N P=0.317N P=0.297N P=0.273N |
|COCHRAN-ARMITAGE | P=0.141N | P=0.247N |
|FISHER EXACT | P=0.187N P=0.187N P=0.187N | P=0.310N P=0.320N P=0.310N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 0/79 (0%) 2/79 (3%) 0/80 (0%) | 0/80 (0%) 1/80 (1%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 4.5% 0.0% | 0.0% 2.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 0/43 (0%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 736 (T) --- | --- 677 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.471N P=0.500N P=0.508 P=0.505N | P=0.552N P=0.486 (e) (e) |
|INCIDENTAL TUMOR | P=0.471N P=0.500N P=0.508 P=0.505N | P=0.813N P=0.567 (e) (e) |
|LOGISTIC REGRESSION | P=0.471N P=0.500N P=0.508 P=0.505N | P=0.556N P=0.496 (e) (e) |
|COCHRAN-ARMITAGE | P=0.465N | P=0.559N |
|FISHER EXACT | P=0.503N P=0.495 P=0.500N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 0/79 (0%) 2/79 (3%) 0/80 (0%) | 0/80 (0%) 1/80 (1%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 0.0% | 0.0% 2.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/43 (0%) 2/44 (5%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) --- | --- 677 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.587 (e) P=0.244 (e) | P=0.552N P=0.486 (e) (e) |
|INCIDENTAL TUMOR | P=0.587 (e) P=0.244 (e) | P=0.813N P=0.567 (e) (e) |
|LOGISTIC REGRESSION | P=0.587 (e) P=0.244 (e) | P=0.556N P=0.496 (e) (e) |
|COCHRAN-ARMITAGE | P=0.591 | P=0.559N |
|FISHER EXACT | (e) P=0.245 (e) | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 0/79 (0%) 2/79 (3%) 1/80 (1%) | 1/79 (1%) 0/80 (0%) 1/78 (1%) 0/80 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 2.4% | 2.0% 0.0% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/43 (0%) 2/44 (5%) 1/42 (2%) | 0/41 (0%) 0/38 (0%) 1/42 (2%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) 736 (T) | 523 --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.237 (e) P=0.244 P=0.495 | P=0.398N P=0.504N P=0.758 P=0.500N |
|INCIDENTAL TUMOR | P=0.237 (e) P=0.244 P=0.495 | P=0.539N P=0.581N P=0.505 P=0.718N |
|LOGISTIC REGRESSION | P=0.237 (e) P=0.244 P=0.495 | P=0.406N P=0.497N P=0.760 P=0.498N |
|COCHRAN-ARMITAGE | P=0.244 | P=0.408N |
|FISHER EXACT | (e) P=0.245 P=0.500 | P=0.497N P=0.748 P=0.497N |
|=================================================================================================================================|
| |
|Tooth |
| Odontoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/80 (3%) 2/79 (3%) 2/79 (3%) 1/80 (1%) | 0/80 (0%) 0/80 (0%) 0/78 (0%) 0/80 (0%) |
|ADJUSTED (b) | 4.7% 4.7% 4.5% 2.4% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/43 (5%) 2/43 (5%) 2/44 (5%) 1/42 (2%) | 0/41 (0%) 0/38 (0%) 0/42 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) 736 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379N P=0.695 P=0.686N P=0.508N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.379N P=0.695 P=0.686N P=0.508N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.379N P=0.695 P=0.686N P=0.508N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.372N | (e) |
|FISHER EXACT | P=0.685 P=0.685 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/80 (3%) 1/80 (1%) 3/78 (4%) 0/80 (0%) |
|ADJUSTED (b) | | 4.9% 2.6% 7.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 2/41 (5%) 1/38 (3%) 3/42 (7%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) 736 (T) 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.213N P=0.527N P=0.511 P=0.218N |
|INCIDENTAL TUMOR | | P=0.213N P=0.527N P=0.511 P=0.218N |
|LOGISTIC REGRESSION | | P=0.213N P=0.527N P=0.511 P=0.218N |
|COCHRAN-ARMITAGE | | P=0.247N |
|FISHER EXACT | | P=0.500N P=0.488 P=0.248N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/80 (1%) 0/79 (0%) 0/79 (0%) 0/80 (0%) | 0/80 (0%) 0/80 (0%) 4/78 (5%) 0/80 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 0.0% 0.0% | 0.0% 0.0% 9.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/43 (2%) 0/43 (0%) 0/44 (0%) 0/42 (0%) | 0/41 (0%) 0/38 (0%) 4/42 (10%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- --- --- | --- --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.311N P=0.500N P=0.495N P=0.505N | P=0.532 (e) P=0.066 (e) |
|INCIDENTAL TUMOR | P=0.311N P=0.500N P=0.495N P=0.505N | P=0.532 (e) P=0.066 (e) |
|LOGISTIC REGRESSION | P=0.311N P=0.500N P=0.495N P=0.505N | P=0.532 (e) P=0.066 (e) |
|COCHRAN-ARMITAGE | P=0.309N | P=0.494 |
|FISHER EXACT | P=0.503N P=0.503N P=0.500N | (e) P=0.057 (e) |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/80 (6%) 2/79 (3%) 4/79 (5%) 2/80 (3%) | 4/80 (5%) 1/80 (1%) 1/78 (1%) 1/80 (1%) |
|ADJUSTED (b) | 11.6% 4.7% 8.4% 4.7% | 9.8% 2.3% 2.4% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 5/43 (12%) 2/43 (5%) 3/44 (7%) 1/42 (2%) | 4/41 (10%) 0/38 (0%) 1/42 (2%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 460 (I) 731 | 736 (T) 652 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.245N P=0.216N P=0.487N P=0.227N | P=0.119N P=0.202N P=0.172N P=0.153N |
|INCIDENTAL TUMOR | P=0.220N P=0.216N P=0.487N P=0.156N | P=0.149N P=0.179N P=0.172N P=0.153N |
|LOGISTIC REGRESSION | P=0.236N P=0.216N P=0.488N P=0.212N | P=0.128N P=0.191N P=0.172N P=0.153N |
|COCHRAN-ARMITAGE | P=0.239N | P=0.140N |
|FISHER EXACT | P=0.226N P=0.508N P=0.221N | P=0.184N P=0.191N P=0.184N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/80 (8%) 2/79 (3%) 4/79 (5%) 2/80 (3%) | 4/80 (5%) 1/80 (1%) 5/78 (6%) 1/80 (1%) |
|ADJUSTED (b) | 14.0% 4.7% 8.4% 4.7% | 9.8% 2.3% 11.9% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 6/43 (14%) 2/43 (5%) 3/44 (7%) 1/42 (2%) | 4/41 (10%) 0/38 (0%) 5/42 (12%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 460 (I) 731 | 736 (T) 652 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162N P=0.134N P=0.358N P=0.143N | P=0.212N P=0.202N P=0.515 P=0.153N |
|INCIDENTAL TUMOR | P=0.143N P=0.134N P=0.358N P=0.094N | P=0.252N P=0.179N P=0.515 P=0.153N |
|LOGISTIC REGRESSION | P=0.153N P=0.134N P=0.357N P=0.130N | P=0.231N P=0.191N P=0.515 P=0.153N |
|COCHRAN-ARMITAGE | P=0.158N | P=0.257N |
|FISHER EXACT | P=0.142N P=0.381N P=0.138N | P=0.184N P=0.484 P=0.184N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/80 (0%) 2/79 (3%) 0/79 (0%) 2/80 (3%) | 1/80 (1%) 3/80 (4%) 2/78 (3%) 1/80 (1%) |
|ADJUSTED (b) | 0.0% 3.9% 0.0% 4.4% | 2.4% 6.6% 4.6% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/43 (0%) 0/43 (0%) 0/44 (0%) 0/42 (0%) | 1/41 (2%) 0/38 (0%) 1/42 (2%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | --- 397 --- 682 | 736 (T) 571 653 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.257 P=0.242 (e) P=0.245 | P=0.441N P=0.296 P=0.506 P=0.741N |
|INCIDENTAL TUMOR | P=0.503 P=0.773 (e) P=0.581 | P=0.591 P=0.457 P=0.447 P=0.741N |
|LOGISTIC REGRESSION | P=0.254 P=0.236 (e) P=0.239 | P=0.580 P=0.301 P=0.498 P=0.741N |
|COCHRAN-ARMITAGE | P=0.254 | P=0.470N |
|FISHER EXACT | P=0.245 (e) P=0.248 | P=0.310 P=0.490 P=0.752N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/80 (4%) 3/79 (4%) 2/79 (3%) 2/80 (3%) | 4/80 (5%) 6/80 (8%) 6/78 (8%) 6/80 (8%) |
|ADJUSTED (b) | 6.7% 7.0% 4.5% 4.8% | 9.5% 15.4% 13.8% 13.3% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/43 (5%) 3/43 (7%) 2/44 (5%) 2/42 (5%) | 3/41 (7%) 5/38 (13%) 5/42 (12%) 6/45 (13%) |
|FIRST INCIDENCE (DAYS) | 603 736 (T) 736 (T) 736 (T) | 698 700 607 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379N P=0.661 P=0.492N P=0.510N | P=0.440 P=0.324 P=0.386 P=0.428 |
|INCIDENTAL TUMOR | P=0.441N P=0.500 P=0.570N P=0.633N | P=0.369 P=0.373 P=0.393 P=0.336 |
|LOGISTIC REGRESSION | P=0.368N P=0.657N P=0.490N P=0.498N | P=0.392 P=0.338 P=0.369 P=0.399 |
|COCHRAN-ARMITAGE | P=0.370N | P=0.354 |
|FISHER EXACT | P=0.653 P=0.506N P=0.500N | P=0.373 P=0.357 P=0.373 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 33/80 (41%) 24/79 (30%) 35/79 (44%) 35/80 (44%) | 28/80 (35%) 31/80 (39%) 25/78 (32%) 32/80 (40%) |
|ADJUSTED (b) | 61.3% 52.7% 71.1% 72.4% | 61.8% 68.2% 56.5% 66.5% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 5/10 (50%) 1/10 (10%) 3/10 (30%) 3/10 (30%) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 1/9 (11%) |
|TERMINAL (d) | 23/43 (53%) 22/43 (51%) 30/44 (68%) 29/42 (69%) | 24/41 (59%) 24/38 (63%) 23/42 (55%) 29/45 (64%) |
|FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 461 (I) 461 (I) 461 (I) 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.143 P=0.078N P=0.477 P=0.390 | P=0.501N P=0.237 P=0.311N P=0.456 |
|INCIDENTAL TUMOR | P=0.099 P=0.176N P=0.385 P=0.309 | P=0.476 P=0.359 P=0.344N P=0.384 |
|LOGISTIC REGRESSION | P=0.167 P=0.074N P=0.453 P=0.429 | P=0.382 P=0.303 P=0.362N P=0.316 |
|COCHRAN-ARMITAGE | P=0.202 | P=0.345 |
|FISHER EXACT | P=0.103N P=0.410 P=0.437 | P=0.372 P=0.412N P=0.312 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 22/80 (28%) 23/79 (29%) 17/79 (22%) 21/80 (26%) | 22/80 (28%) 16/80 (20%) 15/78 (19%) 19/80 (24%) |
|ADJUSTED (b) | 47.7% 46.5% 35.2% 45.7% | 47.7% 35.1% 32.5% 38.7% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 19/43 (44%) 17/43 (40%) 13/44 (30%) 17/42 (40%) | 17/41 (41%) 9/38 (24%) 11/42 (26%) 15/45 (33%) |
|FIRST INCIDENCE (DAYS) | 553 397 460 (I) 676 | 538 561 607 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.409N P=0.505 P=0.198N P=0.531N | P=0.264N P=0.244N P=0.114N P=0.250N |
|INCIDENTAL TUMOR | P=0.240N P=0.467N P=0.124N P=0.395N | P=0.536 P=0.089N P=0.164N P=0.487N |
|LOGISTIC REGRESSION | P=0.371N P=0.512 P=0.183N P=0.489N | P=0.533 P=0.072N P=0.145N P=0.412N |
|COCHRAN-ARMITAGE | P=0.383N | P=0.400N |
|FISHER EXACT | P=0.480 P=0.245N P=0.500N | P=0.177N P=0.149N P=0.359N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05100 TEST: 04 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRICRESYL PHOSPHATE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 60 PPM 125 PPM 250 PPM | 0 PPM 60 PPM 125 PPM 250 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 44/80 (55%) 38/79 (48%) 42/79 (53%) 42/80 (53%) | 41/80 (51%) 41/80 (51%) 33/78 (42%) 42/80 (53%) |
|ADJUSTED (b) | 79.6% 74.1% 82.2% 82.2% | 81.8% 83.5% 70.0% 83.9% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 3 (c)| 5/10 (50%) 2/10 (20%) 3/10 (30%) 3/10 (30%) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 1/9 (11%) |
|TERMINAL (d) | 32/43 (74%) 30/43 (70%) 35/44 (80%) 33/42 (79%) | 32/41 (78%) 30/38 (79%) 28/42 (67%) 37/45 (82%) |
|FIRST INCIDENCE (DAYS) | 281 (I) 281 (I) 460 (I) 460 (I) | 425 461 (I) 461 (I) 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.495 P=0.194N P=0.367N P=0.483N | P=0.245N P=0.389 P=0.082N P=0.405N |
|INCIDENTAL TUMOR | P=0.493N P=0.143N P=0.370N P=0.425N | P=0.511 P=0.526N P=0.174N P=0.430 |
|LOGISTIC REGRESSION | P=0.520N P=0.170N P=0.384N P=0.420N | P=0.490 P=0.589 P=0.132N P=0.542 |
|COCHRAN-ARMITAGE | P=0.511N | P=0.517 |
|FISHER EXACT | P=0.238N P=0.471N P=0.437N | P=0.563N P=0.167N P=0.500 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 90 281 460
Female interim sacrifices(days): 90 282 461
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).