TDMS Study 05100-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 04 TIME: 16:52:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B
PATHOLOGIST: A. SINGER CAS: 1330-78-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 04 TIME: 16:52:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES45050 ROUTE: DOSED FEED NTP C#: 61041B
PATHOLOGIST: A. SINGER CAS: 1330-78-5
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 8 CENSORED DEATHS 44 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 40 68 553 581 603 625 627 699 |
| CENSORED DEATHS |
| 90 90 90 90 91 91 91 91 91 96 |
| 96 96 96 96 281 281 281 281 281 281 |
| 281 281 281 281 286 286 286 286 286 460 |
| 460 460 460 460 460 460 460 460 460 462 |
| 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 6 CENSORED DEATHS 46 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 397 481 687 703 703 708 |
| CENSORED DEATHS |
| 60 90 90 90 90 90 91 91 91 91 |
| 91 96 96 96 96 96 281 281 281 281 |
| 281 281 281 281 281 281 286 286 286 286 |
| 286 460 460 460 460 460 460 460 460 460 |
| 460 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 5 CENSORED DEATHS 46 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 572 583 667 698 718 |
| CENSORED DEATHS |
| 90 90 90 90 90 91 91 91 91 91 |
| 96 96 96 96 96 234 281 281 281 281 |
| 281 281 281 281 281 281 286 286 286 286 |
| 286 460 460 460 460 460 460 460 460 460 |
| 460 462 462 462 462 462 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 8 CENSORED DEATHS 45 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 9 518 533 576 676 682 717 731 |
| CENSORED DEATHS |
| 90 90 90 90 90 91 91 91 91 91 |
| 96 96 96 96 96 281 281 281 281 281 |
| 281 281 281 281 281 286 286 286 286 286 |
| 460 460 460 460 460 460 460 460 460 460 |
| 462 462 462 462 462 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 97.9 97.9 97.9 97.9 97.9 97.9 97.9 91.9 87.9 85.9 |
| | |
| | |
|60 PPM | 100.0 100.0 100.0 100.0 98.4 96.4 96.4 96.4 96.4 88.2 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 95.9 95.9 89.8 |
| | |
| | |
|250 PPM | 98.9 98.9 98.9 98.9 98.9 98.9 94.9 92.9 92.9 84.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 60 PPM 125 PPM 250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 85.9% 88.2% 89.8% 84.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.763N P=0.551N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 474.5 613.2 647.6 555.3 |
|NATURAL DEATHS (C) | (93.0) (56.2) (29.8) (83.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 504.1 504.4 509.4 504.1 |
|(STANDARD ERROR) | (25.8) (25.9) (25.6) (25.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 9 CENSORED DEATHS 45 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 425 523 538 560 645 677 694 698 712 |
| CENSORED DEATHS |
| 90 90 90 90 90 91 91 91 91 91 |
| 97 97 97 97 97 282 282 282 282 282 |
| 282 282 282 282 282 286 286 286 286 286 |
| 461 461 461 461 461 461 461 461 461 461 |
| 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 12 CENSORED DEATHS 45 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 413 454 561 571 603 645 652 674 677 689 |
| 696 700 |
| CENSORED DEATHS |
| 90 90 90 90 90 91 91 91 91 91 |
| 97 97 97 97 97 282 282 282 282 282 |
| 282 282 282 282 282 286 286 286 286 286 |
| 461 461 461 461 461 461 461 461 461 461 |
| 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 6 CENSORED DEATHS 47 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 283 607 621 653 723 730 |
| CENSORED DEATHS |
| 22 90 90 90 90 90 91 91 91 91 |
| 91 97 97 97 97 97 278 282 282 282 |
| 282 282 282 282 282 282 282 286 286 286 |
| 286 286 461 461 461 461 461 461 461 461 |
| 461 461 462 462 462 462 462 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 6 CENSORED DEATHS 44 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 79 471 551 555 593 707 |
| CENSORED DEATHS |
| 90 90 90 90 90 91 91 91 91 91 |
| 97 97 97 97 97 282 282 282 282 282 |
| 282 282 282 282 282 286 286 286 286 286 |
| 461 461 461 461 461 461 461 461 461 462 |
| 462 462 462 462 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.5 98.5 94.4 92.4 90.4 82.4 |
| | |
| | |
|60 PPM | 100.0 100.0 100.0 100.0 98.5 96.9 96.9 90.9 86.8 76.7 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 98.5 98.5 98.5 98.5 98.5 92.2 88.0 |
| | |
| | |
|250 PPM | 98.9 98.9 98.9 98.9 98.9 97.0 97.0 91.0 91.0 89.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 60 PPM 125 PPM 250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.4% 76.7% 88.0% 89.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.263N P=0.607 P=0.603N P=0.570N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 608.0 611.3 602.8 492.7 |
|NATURAL DEATHS (C) | (33.4) (27.6) (67.3) (88.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 507.5 503.8 498.8 507.1 |
|(STANDARD ERROR) | (25.2) (25.0) (26.0) (25.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRICRESYL PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
60 PPM = 2
125 PPM = 3
250 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
|
| 4 1 1 4
| 2 2
98 + 1 1 3 3
|
| 4 4
| 2 2
P 96 + 1 13 3
E |
R | 4 4
C | 2 2
E 94 + 1 1 3 3
N |
T | 4 4
|
S 92 + 1 1 3 3
U |
R | 44
V |
I 90 + 223 3
V |
A | 4 4
L |
88 + 1 1 2 2
|
| 4 4
|
86 + 1 1
|
| 44
|
84 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
TRICRESYL PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
60 PPM = 2
125 PPM = 3
250 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100.0 +1 4 3 2 1
|
| 4 3 2 1 2 4 1 3
|
97.5 +
| 2 4 4 2
| 1 1 3 3
|
95.0 + 4422
| 1 1 3 3
|
| 4 2 4 2
P 92.5 + 1 13 3
E |
R | 4 4
C | 2 1 1
E 90.0 + 3 3
N |
T | 22 4 4
| 1 1 33
S 87.5 +
U | 2 2
R |
V |
I 85.0 +
V | 1 1
A |
L |
82.5 + 2 2 1 1
|
|
| 22
80.0 +
|
|
|
77.5 +
| 2 2
|
|
75.0 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.