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TDMS Study 05100-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/09/95       
EXPERIMENT: 05100 TEST: 04                                                                                     TIME: 16:52:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES45050                                ROUTE: DOSED FEED                                              NTP C#: 61041B       
PATHOLOGIST: A. SINGER                                                                                         CAS: 1330-78-5       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/09/95      
EXPERIMENT: 05100 TEST: 04                                                                                     TIME: 16:52:04      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES45050                                ROUTE: DOSED FEED                                              NTP C#: 61041B      
PATHOLOGIST: A. SINGER                                                                                         CAS: 1330-78-5      
                                TRICRESYL PHOSPHATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 8      CENSORED DEATHS 44   TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      40    68    553   581   603   625   627   699                             |
 |  CENSORED DEATHS                                                               |
 |      90    90    90    90    91    91    91    91    91    96                  |
 |      96    96    96    96    281   281   281   281   281   281                 |
 |      281   281   281   281   286   286   286   286   286   460                 |
 |      460   460   460   460   460   460   460   460   460   462                 |
 |      462   462   462   462                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 60 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 6      CENSORED DEATHS 46   TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      397   481   687   703   703   708                                         |
 |  CENSORED DEATHS                                                               |
 |      60    90    90    90    90    90    91    91    91    91                  |
 |      91    96    96    96    96    96    281   281   281   281                 |
 |      281   281   281   281   281   281   286   286   286   286                 |
 |      286   460   460   460   460   460   460   460   460   460                 |
 |      460   462   462   462   462   462                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 125 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 5      CENSORED DEATHS 46   TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      572   583   667   698   718                                               |
 |  CENSORED DEATHS                                                               |
 |      90    90    90    90    90    91    91    91    91    91                  |
 |      96    96    96    96    96    234   281   281   281   281                 |
 |      281   281   281   281   281   281   286   286   286   286                 |
 |      286   460   460   460   460   460   460   460   460   460                 |
 |      460   462   462   462   462   462                                         |
 |                                                                                |
 ==================================================================================
                                TRICRESYL PHOSPHATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 250 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 8      CENSORED DEATHS 45   TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      9     518   533   576   676   682   717   731                             |
 |  CENSORED DEATHS                                                               |
 |      90    90    90    90    90    91    91    91    91    91                  |
 |      96    96    96    96    96    281   281   281   281   281                 |
 |      281   281   281   281   281   286   286   286   286   286                 |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |      462   462   462   462   462                                               |
 |                                                                                |
 ==================================================================================
                                TRICRESYL PHOSPHATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |    97.9  97.9  97.9  97.9  97.9  97.9  97.9  91.9  87.9  85.9      |
 |           |                                                                    |
 |           |                                                                    |
 |60 PPM     |   100.0 100.0 100.0 100.0  98.4  96.4  96.4  96.4  96.4  88.2      |
 |           |                                                                    |
 |           |                                                                    |
 |125 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  95.9  95.9  89.8      |
 |           |                                                                    |
 |           |                                                                    |
 |250 PPM    |    98.9  98.9  98.9  98.9  98.9  98.9  94.9  92.9  92.9  84.8      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        60 PPM       125 PPM      250 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       85.9%        88.2%        89.8%        84.8%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000      P=0.763N     P=0.551N     P=1.000  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       474.5        613.2        647.6        555.3    |
 |NATURAL DEATHS (C)      |       (93.0)       (56.2)       (29.8)       (83.3)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       504.1        504.4        509.4        504.1    |
 |(STANDARD ERROR)        |       (25.8)       (25.9)       (25.6)       (25.9)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                TRICRESYL PHOSPHATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 9      CENSORED DEATHS 45   TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      425   523   538   560   645   677   694   698   712                       |
 |  CENSORED DEATHS                                                               |
 |      90    90    90    90    90    91    91    91    91    91                  |
 |      97    97    97    97    97    282   282   282   282   282                 |
 |      282   282   282   282   282   286   286   286   286   286                 |
 |      461   461   461   461   461   461   461   461   461   461                 |
 |      462   462   462   462   462                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 60 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 12     CENSORED DEATHS 45   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      413   454   561   571   603   645   652   674   677   689                 |
 |      696   700                                                                 |
 |  CENSORED DEATHS                                                               |
 |      90    90    90    90    90    91    91    91    91    91                  |
 |      97    97    97    97    97    282   282   282   282   282                 |
 |      282   282   282   282   282   286   286   286   286   286                 |
 |      461   461   461   461   461   461   461   461   461   461                 |
 |      462   462   462   462   462                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 125 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 6      CENSORED DEATHS 47   TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      283   607   621   653   723   730                                         |
 |  CENSORED DEATHS                                                               |
 |      22    90    90    90    90    90    91    91    91    91                  |
 |      91    97    97    97    97    97    278   282   282   282                 |
 |      282   282   282   282   282   282   282   286   286   286                 |
 |      286   286   461   461   461   461   461   461   461   461                 |
 |      461   461   462   462   462   462   462                                   |
 |                                                                                |
 ==================================================================================
                                TRICRESYL PHOSPHATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 250 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 95     UNCENSORED DEATHS 6      CENSORED DEATHS 44   TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      79    471   551   555   593   707                                         |
 |  CENSORED DEATHS                                                               |
 |      90    90    90    90    90    91    91    91    91    91                  |
 |      97    97    97    97    97    282   282   282   282   282                 |
 |      282   282   282   282   282   286   286   286   286   286                 |
 |      461   461   461   461   461   461   461   461   461   462                 |
 |      462   462   462   462                                                     |
 |                                                                                |
 ==================================================================================
                                TRICRESYL PHOSPHATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  98.5  98.5  94.4  92.4  90.4  82.4      |
 |           |                                                                    |
 |           |                                                                    |
 |60 PPM     |   100.0 100.0 100.0 100.0  98.5  96.9  96.9  90.9  86.8  76.7      |
 |           |                                                                    |
 |           |                                                                    |
 |125 PPM    |   100.0 100.0 100.0  98.5  98.5  98.5  98.5  98.5  92.2  88.0      |
 |           |                                                                    |
 |           |                                                                    |
 |250 PPM    |    98.9  98.9  98.9  98.9  98.9  97.0  97.0  91.0  91.0  89.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        60 PPM       125 PPM      250 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.4%        76.7%        88.0%        89.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.263N     P=0.607      P=0.603N     P=0.570N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       608.0        611.3        602.8        492.7    |
 |NATURAL DEATHS (C)      |       (33.4)       (27.6)       (67.3)       (88.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       507.5        503.8        498.8        507.1    |
 |(STANDARD ERROR)        |       (25.2)       (25.0)       (26.0)       (25.8)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        TRICRESYL PHOSPHATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        60 PPM           = 2
                                                        125 PPM          = 3
                                                        250 PPM          = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 4    1                                                       2                          3
      |
      |   4    1   1                                                                     4
      |                                                                2            2
   98 +            1                                                                           1  3 3
      |
      |                                                                                  4   4
      |                                                                             2                                2
P  96 +                                                                                        1   13             3
E     |
R     |                                                                                      4     4
C     |                                                                                                              2 2
E  94 +                                                                                            1    1         3   3
N     |
T     |                                                                                            4               4
      |
S  92 +                                                                                                 1  1          3  3
U     |
R     |                                                                                                            44
V     |
I  90 +                                                                                                                223   3
V     |
A     |                                                                                                             4    4
L     |
   88 +                                                                                                    1          1 2    2
      |
      |                                                                                                                  4  4
      |
   86 +                                                                                                               1      1
      |
      |                                                                                                                     44
      |
   84 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.
                                                        TRICRESYL PHOSPHATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        60 PPM           = 2
                                                        125 PPM          = 3
                                                        250 PPM          = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

        |
  100.0 +1            4                               3                   2 1
        |
        |             4                               3                   2 1    2  4       1            3
        |
   97.5 +
        |                                                                        2  4           4 2
        |                                                                                   1 1          3 3
        |
   95.0 +                                                                                       4422
        |                                                                                     1  1         3    3
        |
        |                                                                                        4 2   4 2
P  92.5 +                                                                                        1             13          3
E       |
R       |                                                                                              4                4
C       |                                                                                                2     1    1
E  90.0 +                                                                                                                  3 3
N       |
T       |                                                                                                      22       4     4
        |                                                                                                           1  1     33
S  87.5 +
U       |                                                                                                       2   2
R       |
V       |
I  85.0 +
V       |                                                                                                              1 1
A       |
L       |
   82.5 +                                                                                                           2 2  1    1
        |
        |
        |                                                                                                             22
   80.0 +
        |
        |
        |
   77.5 +
        |                                                                                                              2      2
        |
        |
   75.0 +
        |
        -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
         0         10         20         30         40         50         60         70         80         90         100        110

                                                                    WEEK

NOTE: 4 obs hidden.