National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1771

TDMS Study 05100-03 Pathology Tables

NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95
Route: DOSED FEED                                                                                                 Time: 13:06:56




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1330-78-5

       Lock Date:  12/30/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          95           95           95           95           95                        

  Scheduled Sacrifice                                 44           42           45           44           94                        
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            5            5                                     
    Moribund Sacrifice                                14           12           15           18            1                        
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                34           37           30           26                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    95           95           95           94           45                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (80)         (81)         (79)         (80)         (30)                      
      Parasite Metazoan                                                          3 (4%)       1 (1%)       1 (3%)                   
      Ulcer                                            1 (1%)                                                                       
   Intestine Large, Rectum                            (80)         (81)         (78)         (80)         (30)                      
      Fibrosis                                                                                1 (1%)                                
      Inflammation, Necrotizing                                     1 (1%)                                                          
      Parasite Metazoan                                2 (3%)       1 (1%)       6 (8%)                                             
   Intestine Large, Cecum                             (80)         (81)         (80)         (80)         (30)                      
      Ulcer                                            1 (1%)                                                                       
   Intestine Small, Jejunum                           (79)         (80)         (78)         (77)         (30)                      
      Ulcer                                            1 (1%)                                                                       
      Peyer's Patch, Mineralization                                 1 (1%)                                                          
   Intestine Small, Ileum                             (80)         (81)         (78)         (78)         (30)                      
      Ulcer                                            1 (1%)                                                                       
   Liver                                              (80)         (81)         (80)         (80)         (30)                      
      Basophilic Focus                                21 (26%)     21 (26%)     25 (31%)     23 (29%)      1 (3%)                   
      Clear Cell Focus                                 1 (1%)                    1 (1%)                                             
      Cyst                                             2 (3%)                                                                       
      Degeneration, Cystic                             1 (1%)                    1 (1%)       1 (1%)                                
      Degeneration, Fatty                                                                     1 (1%)                                
      Eosinophilic Focus                               3 (4%)       3 (4%)       3 (4%)       7 (9%)                                
      Fatty Change                                                  2 (2%)       2 (3%)       2 (3%)                                
      Hepatodiaphragmatic Nodule                       7 (9%)      11 (14%)      4 (5%)       7 (9%)       3 (10%)                  
      Hyperplasia                                                                             1 (1%)                                
      Inflammation, Granulomatous                      2 (3%)       6 (7%)       2 (3%)       3 (4%)       1 (3%)                   
      Mixed Cell Focus                                 5 (6%)       4 (5%)       5 (6%)       4 (5%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Mesentery                                          (4)          (7)          (4)          (4)          (1)                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hemorrhage                                                                              1 (25%)                               
      Fat, Necrosis                                    4 (100%)     5 (71%)      4 (100%)     3 (75%)      1 (100%)                 
   Pancreas                                           (80)         (81)         (80)         (80)         (30)                      
      Inflammation, Chronic                            3 (4%)                                 1 (1%)                                
      Acinus, Atrophy                                 17 (21%)     12 (15%)     22 (28%)     14 (18%)                               
   Salivary Glands                                    (80)         (81)         (79)         (80)         (30)                      
      Inflammation, Chronic                            1 (1%)                                                                       
   Stomach, Forestomach                               (80)         (81)         (79)         (80)         (30)                      
      Cyst Epithelial Inclusion                                                               1 (1%)                                
      Ulcer                                                                      1 (1%)       1 (1%)                                
      Epithelium, Hyperplasia                                       1 (1%)       2 (3%)       4 (5%)                                
   Stomach, Glandular                                 (80)         (81)         (80)         (80)         (30)                      
      Ulcer                                            1 (1%)                    2 (3%)       1 (1%)                                
      Mucosa, Mineralization                                        2 (2%)       1 (1%)                                             
   Tongue                                                          (1)                                                              
      Mucosa, Epithelium, Hyperplasia                               1 (100%)                                                        
   Tooth                                              (1)          (1)                                                              
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (81)         (80)         (80)         (30)                      
      Degeneration                                     1 (1%)                    1 (1%)       3 (4%)                                
      Artery, Inflammation, Chronic                                 1 (1%)                                                          
      Myocardium, Degeneration                        37 (46%)     36 (44%)     37 (46%)     33 (41%)      1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (81)         (80)         (80)         (29)                      
      Hyperplasia                                     18 (23%)     14 (17%)     18 (23%)     22 (28%)      3 (10%)                  
      Mineralization                                                             1 (1%)                                             
      Vacuolization Cytoplasmic                       15 (19%)     12 (15%)     20 (25%)     66 (83%)      9 (31%)                  
   Adrenal Medulla                                    (80)         (81)         (80)         (80)         (29)                      
      Hyperplasia                                      6 (8%)                    1 (1%)       2 (3%)                                
      Infarct                                                       1 (1%)                                                          
   Pituitary Gland                                    (80)         (81)         (80)         (80)         (30)                      
      Cyst                                             1 (1%)       5 (6%)       5 (6%)       5 (6%)                                
      Inflammation, Chronic                                                                   1 (1%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
      Pars Distalis, Cyst                                           1 (1%)       2 (3%)       1 (1%)       1 (3%)                   
      Pars Distalis, Hyperplasia                       3 (4%)       6 (7%)       7 (9%)       4 (5%)       2 (7%)                   
   Thyroid Gland                                      (80)         (81)         (80)         (80)         (30)                      
      C-Cell, Hyperplasia                             37 (46%)     44 (54%)     52 (65%)     39 (49%)      8 (27%)                  
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (80)         (81)         (79)         (79)         (30)                      
      Abscess                                          1 (1%)                                                                       
      Hyperplasia                                      5 (6%)       2 (2%)                                                          
      Inflammation, Chronic                            5 (6%)       5 (6%)       5 (6%)       3 (4%)       1 (3%)                   
      Inflammation, Chronic Active                     1 (1%)       2 (2%)       1 (1%)       4 (5%)       2 (7%)                   
   Ovary                                              (80)         (81)         (80)         (80)         (30)                      
      Cyst                                             3 (4%)       6 (7%)       1 (1%)       5 (6%)                                
      Follicle, Cyst                                                                          1 (1%)                                
      Interstitium, Hyperplasia                                                 10 (13%)     44 (55%)     14 (47%)                  
   Uterus                                             (80)         (81)         (80)         (80)         (30)                      
      Dilatation                                       2 (3%)                    1 (1%)       5 (6%)       1 (3%)                   
      Prolapse                                         2 (3%)                                                                       
      Cervix, Cyst                                                  2 (2%)                    1 (1%)                                
      Endometrium, Hyperplasia                         7 (9%)       6 (7%)       1 (1%)       1 (1%)                                
      Wall, Hyperplasia                                                          1 (1%)       1 (1%)                                
   Vagina                                                                                                 (1)                       
      Inflammation                                                                                         1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (1)          (1)                                                 
      Anisocytosis                                                               1 (100%)                                           
      Polychromasia                                                              1 (100%)                                           
   Bone Marrow                                        (80)         (81)         (80)         (80)         (30)                      
      Atrophy                                                                    1 (1%)                                             
   Lymph Node, Mandibular                             (80)         (81)         (78)         (80)         (30)                      
      Hyperplasia, Lymphoid                                                      1 (1%)                                             
   Spleen                                             (79)         (81)         (80)         (80)         (30)                      
      Congestion                                                                 1 (1%)                                             
      Depletion Lymphoid                                                                      1 (1%)                                
      Erythrophagocytosis                                                        1 (1%)                                             
      Fibrosis                                         1 (1%)       2 (2%)                                                          
      Inflammation, Granulomatous                      1 (1%)       3 (4%)                    1 (1%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (77)         (81)         (79)         (79)         (30)                      
      Hyperplasia, Cystic                              1 (1%)       3 (4%)       1 (1%)       1 (1%)       1 (3%)                   
   Skin                                               (80)         (81)         (80)         (80)         (30)                      
      Abscess                                                                    1 (1%)       1 (1%)                                
      Inflammation, Chronic                                         1 (1%)       2 (3%)                    1 (3%)                   
      Ulcer                                                                                                1 (3%)                   
      Subcutaneous Tissue, Edema                                                              1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (81)         (80)         (80)         (29)                      
      Osteopetrosis                                    1 (1%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (81)         (80)         (80)         (30)                      
      Gliosis                                                                                 1 (1%)                                
      Hypothalamus, Compression                       13 (16%)      5 (6%)       6 (8%)      12 (15%)                               
   Spinal Cord                                        (95)         (93)         (95)         (94)         (45)                      
      Cyst                                             2 (2%)                    2 (2%)                                             
      Axon, Degeneration                                            1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (81)         (80)         (80)         (30)                      
      Inflammation, Chronic                            5 (6%)       6 (7%)       2 (3%)       1 (1%)                                
      Fat, Mediastinum, Necrosis                                                 1 (1%)                                             
   Nose                                               (80)         (81)         (80)         (80)         (30)                      
      Hemorrhage                                                                              1 (1%)                                
      Inflammation, Necrotizing                                                               1 (1%)                                
      Inflammation, Suppurative                                     2 (2%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (5)                       (2)                                    
      Hemorrhage                                                    1 (20%)                                                         
      Synechia                                                                                1 (50%)                               
      Cornea, Inflammation, Chronic                                 1 (20%)                                                         
      Lens, Cataract                                   1 (100%)     3 (60%)                   1 (50%)                               
   Harderian Gland                                    (1)          (3)                                    (1)                       
      Inflammation, Chronic Active                     1 (100%)     2 (67%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (81)         (80)         (80)         (30)                      
      Infarct                                          1 (1%)                                 1 (1%)                                
      Nephropathy                                     46 (58%)     41 (51%)     39 (49%)     34 (43%)      6 (20%)                  
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          95           95           95           95           95                        

  Scheduled Sacrifice                                 44           45           45           45           95                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           16           11           16                                     
    Natural Death                                      5            4            4            6                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                                            
    Terminal Sacrifice                                31           30           35           28                                     

  Animals Examined Microscopically                    95           95           95           95           45                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (79)         (79)         (79)         (79)         (30)                      
      Parasite Metazoan                                2 (3%)       2 (3%)       3 (4%)       5 (6%)       2 (7%)                   
   Intestine Large, Rectum                            (80)         (79)         (78)         (79)         (30)                      
      Parasite Metazoan                                7 (9%)       1 (1%)       8 (10%)      8 (10%)      1 (3%)                   
   Intestine Small, Jejunum                           (78)         (79)         (78)         (79)         (30)                      
      Ulcer                                                         1 (1%)                    1 (1%)                                
   Intestine Small, Ileum                             (78)         (79)         (78)         (79)         (30)                      
      Ulcer                                                                      1 (1%)                                             
      Venule, Parasite Metazoan                        1 (1%)                                                                       
   Liver                                              (79)         (80)         (79)         (80)         (30)                      
      Angiectasis                                                                             1 (1%)                                
      Basophilic Focus                                 3 (4%)       8 (10%)      6 (8%)       7 (9%)                                
      Clear Cell Focus                                 1 (1%)       1 (1%)       2 (3%)       1 (1%)                                
      Degeneration, Cystic                             7 (9%)       1 (1%)       7 (9%)       5 (6%)                                
      Eosinophilic Focus                               9 (11%)      4 (5%)       7 (9%)       6 (8%)                                
      Fatty Change                                     1 (1%)       1 (1%)       1 (1%)                                             
      Hepatodiaphragmatic Nodule                       5 (6%)       5 (6%)       5 (6%)       6 (8%)       1 (3%)                   
      Hyperplasia                                                   2 (3%)       2 (3%)                                             
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Granulomatous                      1 (1%)                                                                       
      Mixed Cell Focus                                 1 (1%)       1 (1%)       1 (1%)       1 (1%)                                
      Necrosis                                         1 (1%)                    2 (3%)       2 (3%)                                
   Mesentery                                          (6)          (8)          (5)          (9)          (2)                       
      Inflammation, Chronic                            1 (17%)      1 (13%)                                                         
      Artery, Inflammation, Chronic                                                           1 (11%)                               
      Fat, Necrosis                                    4 (67%)      7 (88%)      4 (80%)      6 (67%)      2 (100%)                 
   Pancreas                                           (80)         (80)         (79)         (80)         (30)                      
      Inflammation, Chronic                            2 (3%)       1 (1%)       2 (3%)       2 (3%)       1 (3%)                   
      Acinus, Atrophy                                 26 (33%)     28 (35%)     24 (30%)     20 (25%)      4 (13%)                  
      Acinus, Hyperplasia                                           2 (3%)                                                          
   Stomach, Forestomach                               (80)         (80)         (80)         (80)         (30)                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst Epithelial Inclusion                                                  1 (1%)                                             
      Ulcer                                            2 (3%)                    1 (1%)                                             
   Stomach, Glandular                                 (80)         (80)         (80)         (80)         (30)                      
      Ulcer                                            2 (3%)       2 (3%)       3 (4%)       3 (4%)                                
   Tongue                                                                       (1)          (2)                                    
      Epithelium, Hyperplasia                                                    1 (100%)                                           
      Mucosa, Epithelium, Hyperplasia                                                         2 (100%)                              
   Tooth                                                                                     (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (80)         (80)         (80)         (30)                      
      Degeneration                                     7 (9%)      10 (13%)      8 (10%)      6 (8%)       8 (27%)                  
      Artery, Inflammation, Chronic                                 1 (1%)                                                          
      Atrium, Dilatation                               1 (1%)                                 1 (1%)                                
      Atrium, Thrombosis                               2 (3%)       1 (1%)       2 (3%)                                             
      Intima, Hyperplasia                              1 (1%)                                                                       
      Myocardium, Degeneration                        48 (60%)     55 (69%)     54 (68%)     50 (63%)     12 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (79)         (79)         (80)         (79)         (30)                      
      Hyperplasia                                      9 (11%)     17 (22%)     10 (13%)     13 (16%)      1 (3%)                   
      Vacuolization Cytoplasmic                                                                           10 (33%)                  
   Adrenal Medulla                                    (79)         (80)         (80)         (80)         (28)                      
      Hyperplasia                                     11 (14%)      4 (5%)       6 (8%)      10 (13%)      1 (4%)                   
   Islets, Pancreatic                                 (80)         (80)         (79)         (80)         (30)                      
      Hyperplasia                                      1 (1%)       2 (3%)                    3 (4%)                                
   Pituitary Gland                                    (80)         (80)         (80)         (80)         (30)                      
      Cyst                                             1 (1%)       2 (3%)                    1 (1%)                                
      Pars Distalis, Cyst                                                                                  1 (3%)                   
      Pars Distalis, Degeneration, Focal                            1 (1%)                                                          
      Pars Distalis, Hyperplasia                       3 (4%)       6 (8%)      10 (13%)     11 (14%)      2 (7%)                   
      Pars Distalis, Inflammation, Chronic                          1 (1%)                                                          
      Pars Distalis, Mineralization                    1 (1%)                                                                       
      Pars Intermedia, Hyperplasia                                                                         1 (3%)                   
   Thyroid Gland                                      (80)         (80)         (80)         (79)         (30)                      
      C-Cell, Hyperplasia                             32 (40%)     42 (53%)     48 (60%)     43 (54%)     10 (33%)                  
      Follicle, Dilatation                                          3 (4%)                                                          
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (80)         (80)         (80)         (30)                      
      Aspermia                                                                                             1 (3%)                   
      Hypospermia                                                                1 (1%)                                             
      Inflammation, Chronic Active                                  1 (1%)                                                          
   Preputial Gland                                    (79)         (79)         (77)         (79)         (30)                      
      Hyperplasia                                      1 (1%)       1 (1%)                                                          
      Inflammation, Chronic                           14 (18%)     23 (29%)     14 (18%)     11 (14%)      6 (20%)                  
      Inflammation, Chronic Active                     7 (9%)       5 (6%)       8 (10%)      6 (8%)       9 (30%)                  
   Prostate                                           (80)         (80)         (80)         (80)         (30)                      
      Abscess                                                       1 (1%)                                                          
      Inflammation, Chronic                                                      1 (1%)       2 (3%)                                
      Inflammation, Chronic Active                     2 (3%)       4 (5%)       4 (5%)       6 (8%)       6 (20%)                  
   Seminal Vesicle                                    (80)         (80)         (80)         (80)         (30)                      
      Inflammation, Chronic                                         1 (1%)                    1 (1%)                                
   Testes                                             (80)         (80)         (80)         (80)         (30)                      
      Atrophy                                          1 (1%)                                                                       
      Hypospermia                                                                1 (1%)                                             
      Interstitial Cell, Hyperplasia                   1 (1%)                                                                       
      Seminiferous Tubule, Atrophy                                  2 (3%)       2 (3%)       3 (4%)       1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (78)         (80)         (80)         (79)         (29)                      
      Hyperplasia, Lymphoid                                                                   1 (1%)                                
   Lymph Node, Mesenteric                             (80)         (79)         (80)         (80)         (29)                      
      Cyst                                                                       1 (1%)                                             
      Inflammation, Granulomatous                                   1 (1%)                                                          
   Spleen                                             (79)         (80)         (80)         (80)         (30)                      
      Congestion                                       1 (1%)                                                                       
      Fibrosis                                         3 (4%)       2 (3%)       2 (3%)       6 (8%)                                
      Hematopoietic Cell Proliferation                              1 (1%)       2 (3%)                                             
      Hyperplasia, Lymphoid                                         1 (1%)                                                          
      Infarct                                                       2 (3%)                                                          
      Capsule, Inflammation, Chronic                                                          1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (75)         (75)         (75)         (74)         (29)                      
      Hyperplasia, Cystic                                                        2 (3%)                                             
   Skin                                               (80)         (79)         (80)         (80)         (29)                      
      Abscess                                                       1 (1%)                    1 (1%)                                
      Acanthosis                                                                              1 (1%)                                
      Cyst Epithelial Inclusion                                                  1 (1%)                                             
      Hyperkeratosis                                                                          1 (1%)                                
      Inflammation, Chronic                                         1 (1%)                                                          
      Ulcer                                                         1 (1%)       1 (1%)       2 (3%)                                
      Dermis, Mineralization                           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (80)         (80)         (80)         (30)                      
      Inflammation, Chronic                                                                   1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (79)         (80)         (80)         (30)                      
      Hydrocephalus                                                 1 (1%)                                                          
      Infarct                                                       1 (1%)                                                          
      Hypothalamus, Compression                        1 (1%)       1 (1%)       2 (3%)       2 (3%)                                
   Peripheral Nerve                                   (95)         (95)         (93)         (95)         (45)                      
      Axon, Degeneration                                            1 (1%)                                                          
   Spinal Cord                                        (95)         (95)         (95)         (94)         (45)                      
      Cyst                                             2 (2%)       1 (1%)                    1 (1%)       1 (2%)                   
      Nerve, Degeneration                                                                     1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (80)         (80)         (80)         (30)                      
      Erythrophagocytosis                                                        1 (1%)                                             
      Hemorrhage                                                                              1 (1%)                                
      Inflammation, Chronic                            3 (4%)       4 (5%)       1 (1%)       3 (4%)                                
   Nose                                               (80)         (80)         (80)         (80)         (30)                      
      Inflammation, Suppurative                        2 (3%)       2 (3%)       4 (5%)       2 (3%)                                
      Nares, Hemorrhage                                1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)          (1)                                    
      Pinna, Ulcer                                                               1 (100%)                                           
   Eye                                                (8)          (4)          (1)          (1)                                    
      Inflammation, Chronic                            1 (13%)                                                                      
      Phthisis Bulbi                                                             1 (100%)                                           
      Lens, Cataract                                   4 (50%)      3 (75%)                                                         
      Lens, Cataract, Focal                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (80)         (80)         (80)         (30)                      
      Hydronephrosis                                                                          1 (1%)                                
      Infarct                                                       1 (1%)                                                          
      Nephropathy                                     61 (76%)     61 (76%)     60 (75%)     56 (70%)     15 (50%)                  
   Urinary Bladder                                    (80)         (79)         (80)         (80)         (30)                      
      Inflammation, Chronic                                         1 (1%)                                                          
      Mucosa, Ulcer                                                                           1 (1%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.