Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1771

TDMS Study 05100-03 Pathology Tables

NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95
Route: DOSED FEED                                                                                                 Time: 13:06:56




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1330-78-5

       Lock Date:  12/30/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          95           95           95           95           95                        

  Scheduled Sacrifice                                 44           42           45           44           94                        
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            5            5                                     
    Moribund Sacrifice                                14           12           15           18            1                        
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                34           37           30           26                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    95           95           95           94           45                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (80)         (81)         (79)         (80)         (30)                      
      Parasite Metazoan                                                          3 (4%)       1 (1%)       1 (3%)                   
      Ulcer                                            1 (1%)                                                                       
   Intestine Large, Rectum                            (80)         (81)         (78)         (80)         (30)                      
      Fibrosis                                                                                1 (1%)                                
      Inflammation, Necrotizing                                     1 (1%)                                                          
      Parasite Metazoan                                2 (3%)       1 (1%)       6 (8%)                                             
   Intestine Large, Cecum                             (80)         (81)         (80)         (80)         (30)                      
      Ulcer                                            1 (1%)                                                                       
   Intestine Small, Jejunum                           (79)         (80)         (78)         (77)         (30)                      
      Ulcer                                            1 (1%)                                                                       
      Peyer's Patch, Mineralization                                 1 (1%)                                                          
   Intestine Small, Ileum                             (80)         (81)         (78)         (78)         (30)                      
      Ulcer                                            1 (1%)                                                                       
   Liver                                              (80)         (81)         (80)         (80)         (30)                      
      Basophilic Focus                                21 (26%)     21 (26%)     25 (31%)     23 (29%)      1 (3%)                   
      Clear Cell Focus                                 1 (1%)                    1 (1%)                                             
      Cyst                                             2 (3%)                                                                       
      Degeneration, Cystic                             1 (1%)                    1 (1%)       1 (1%)                                
      Degeneration, Fatty                                                                     1 (1%)                                
      Eosinophilic Focus                               3 (4%)       3 (4%)       3 (4%)       7 (9%)                                
      Fatty Change                                                  2 (2%)       2 (3%)       2 (3%)                                
      Hepatodiaphragmatic Nodule                       7 (9%)      11 (14%)      4 (5%)       7 (9%)       3 (10%)                  
      Hyperplasia                                                                             1 (1%)                                
      Inflammation, Granulomatous                      2 (3%)       6 (7%)       2 (3%)       3 (4%)       1 (3%)                   
      Mixed Cell Focus                                 5 (6%)       4 (5%)       5 (6%)       4 (5%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Mesentery                                          (4)          (7)          (4)          (4)          (1)                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hemorrhage                                                                              1 (25%)                               
      Fat, Necrosis                                    4 (100%)     5 (71%)      4 (100%)     3 (75%)      1 (100%)                 
   Pancreas                                           (80)         (81)         (80)         (80)         (30)                      
      Inflammation, Chronic                            3 (4%)                                 1 (1%)                                
      Acinus, Atrophy                                 17 (21%)     12 (15%)     22 (28%)     14 (18%)                               
   Salivary Glands                                    (80)         (81)         (79)         (80)         (30)                      
      Inflammation, Chronic                            1 (1%)                                                                       
   Stomach, Forestomach                               (80)         (81)         (79)         (80)         (30)                      
      Cyst Epithelial Inclusion                                                               1 (1%)                                
      Ulcer                                                                      1 (1%)       1 (1%)                                
      Epithelium, Hyperplasia                                       1 (1%)       2 (3%)       4 (5%)                                
   Stomach, Glandular                                 (80)         (81)         (80)         (80)         (30)                      
      Ulcer                                            1 (1%)                    2 (3%)       1 (1%)                                
      Mucosa, Mineralization                                        2 (2%)       1 (1%)                                             
   Tongue                                                          (1)                                                              
      Mucosa, Epithelium, Hyperplasia                               1 (100%)                                                        
   Tooth                                              (1)          (1)                                                              
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (81)         (80)         (80)         (30)                      
      Degeneration                                     1 (1%)                    1 (1%)       3 (4%)                                
      Artery, Inflammation, Chronic                                 1 (1%)                                                          
      Myocardium, Degeneration                        37 (46%)     36 (44%)     37 (46%)     33 (41%)      1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (81)         (80)         (80)         (29)                      
      Hyperplasia                                     18 (23%)     14 (17%)     18 (23%)     22 (28%)      3 (10%)                  
      Mineralization                                                             1 (1%)                                             
      Vacuolization Cytoplasmic                       15 (19%)     12 (15%)     20 (25%)     66 (83%)      9 (31%)                  
   Adrenal Medulla                                    (80)         (81)         (80)         (80)         (29)                      
      Hyperplasia                                      6 (8%)                    1 (1%)       2 (3%)                                
      Infarct                                                       1 (1%)                                                          
   Pituitary Gland                                    (80)         (81)         (80)         (80)         (30)                      
      Cyst                                             1 (1%)       5 (6%)       5 (6%)       5 (6%)                                
      Inflammation, Chronic                                                                   1 (1%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
      Pars Distalis, Cyst                                           1 (1%)       2 (3%)       1 (1%)       1 (3%)                   
      Pars Distalis, Hyperplasia                       3 (4%)       6 (7%)       7 (9%)       4 (5%)       2 (7%)                   
   Thyroid Gland                                      (80)         (81)         (80)         (80)         (30)                      
      C-Cell, Hyperplasia                             37 (46%)     44 (54%)     52 (65%)     39 (49%)      8 (27%)                  
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (80)         (81)         (79)         (79)         (30)                      
      Abscess                                          1 (1%)                                                                       
      Hyperplasia                                      5 (6%)       2 (2%)                                                          
      Inflammation, Chronic                            5 (6%)       5 (6%)       5 (6%)       3 (4%)       1 (3%)                   
      Inflammation, Chronic Active                     1 (1%)       2 (2%)       1 (1%)       4 (5%)       2 (7%)                   
   Ovary                                              (80)         (81)         (80)         (80)         (30)                      
      Cyst                                             3 (4%)       6 (7%)       1 (1%)       5 (6%)                                
      Follicle, Cyst                                                                          1 (1%)                                
      Interstitium, Hyperplasia                                                 10 (13%)     44 (55%)     14 (47%)                  
   Uterus                                             (80)         (81)         (80)         (80)         (30)                      
      Dilatation                                       2 (3%)                    1 (1%)       5 (6%)       1 (3%)                   
      Prolapse                                         2 (3%)                                                                       
      Cervix, Cyst                                                  2 (2%)                    1 (1%)                                
      Endometrium, Hyperplasia                         7 (9%)       6 (7%)       1 (1%)       1 (1%)                                
      Wall, Hyperplasia                                                          1 (1%)       1 (1%)                                
   Vagina                                                                                                 (1)                       
      Inflammation                                                                                         1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (1)          (1)                                                 
      Anisocytosis                                                               1 (100%)                                           
      Polychromasia                                                              1 (100%)                                           
   Bone Marrow                                        (80)         (81)         (80)         (80)         (30)                      
      Atrophy                                                                    1 (1%)                                             
   Lymph Node, Mandibular                             (80)         (81)         (78)         (80)         (30)                      
      Hyperplasia, Lymphoid                                                      1 (1%)                                             
   Spleen                                             (79)         (81)         (80)         (80)         (30)                      
      Congestion                                                                 1 (1%)                                             
      Depletion Lymphoid                                                                      1 (1%)                                
      Erythrophagocytosis                                                        1 (1%)                                             
      Fibrosis                                         1 (1%)       2 (2%)                                                          
      Inflammation, Granulomatous                      1 (1%)       3 (4%)                    1 (1%)                                
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (77)         (81)         (79)         (79)         (30)                      
      Hyperplasia, Cystic                              1 (1%)       3 (4%)       1 (1%)       1 (1%)       1 (3%)                   
   Skin                                               (80)         (81)         (80)         (80)         (30)                      
      Abscess                                                                    1 (1%)       1 (1%)                                
      Inflammation, Chronic                                         1 (1%)       2 (3%)                    1 (3%)                   
      Ulcer                                                                                                1 (3%)                   
      Subcutaneous Tissue, Edema                                                              1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (81)         (80)         (80)         (29)                      
      Osteopetrosis                                    1 (1%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (81)         (80)         (80)         (30)                      
      Gliosis                                                                                 1 (1%)                                
      Hypothalamus, Compression                       13 (16%)      5 (6%)       6 (8%)      12 (15%)                               
   Spinal Cord                                        (95)         (93)         (95)         (94)         (45)                      
      Cyst                                             2 (2%)                    2 (2%)                                             
      Axon, Degeneration                                            1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (81)         (80)         (80)         (30)                      
      Inflammation, Chronic                            5 (6%)       6 (7%)       2 (3%)       1 (1%)                                
      Fat, Mediastinum, Necrosis                                                 1 (1%)                                             
   Nose                                               (80)         (81)         (80)         (80)         (30)                      
      Hemorrhage                                                                              1 (1%)                                
      Inflammation, Necrotizing                                                               1 (1%)                                
      Inflammation, Suppurative                                     2 (2%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (5)                       (2)                                    
      Hemorrhage                                                    1 (20%)                                                         
      Synechia                                                                                1 (50%)                               
      Cornea, Inflammation, Chronic                                 1 (20%)                                                         
      Lens, Cataract                                   1 (100%)     3 (60%)                   1 (50%)                               
   Harderian Gland                                    (1)          (3)                                    (1)                       
      Inflammation, Chronic Active                     1 (100%)     2 (67%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (81)         (80)         (80)         (30)                      
      Infarct                                          1 (1%)                                 1 (1%)                                
      Nephropathy                                     46 (58%)     41 (51%)     39 (49%)     34 (43%)      6 (20%)                  
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          95           95           95           95           95                        

  Scheduled Sacrifice                                 44           45           45           45           95                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           16           11           16                                     
    Natural Death                                      5            4            4            6                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                                            
    Terminal Sacrifice                                31           30           35           28                                     

  Animals Examined Microscopically                    95           95           95           95           45                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (79)         (79)         (79)         (79)         (30)                      
      Parasite Metazoan                                2 (3%)       2 (3%)       3 (4%)       5 (6%)       2 (7%)                   
   Intestine Large, Rectum                            (80)         (79)         (78)         (79)         (30)                      
      Parasite Metazoan                                7 (9%)       1 (1%)       8 (10%)      8 (10%)      1 (3%)                   
   Intestine Small, Jejunum                           (78)         (79)         (78)         (79)         (30)                      
      Ulcer                                                         1 (1%)                    1 (1%)                                
   Intestine Small, Ileum                             (78)         (79)         (78)         (79)         (30)                      
      Ulcer                                                                      1 (1%)                                             
      Venule, Parasite Metazoan                        1 (1%)                                                                       
   Liver                                              (79)         (80)         (79)         (80)         (30)                      
      Angiectasis                                                                             1 (1%)                                
      Basophilic Focus                                 3 (4%)       8 (10%)      6 (8%)       7 (9%)                                
      Clear Cell Focus                                 1 (1%)       1 (1%)       2 (3%)       1 (1%)                                
      Degeneration, Cystic                             7 (9%)       1 (1%)       7 (9%)       5 (6%)                                
      Eosinophilic Focus                               9 (11%)      4 (5%)       7 (9%)       6 (8%)                                
      Fatty Change                                     1 (1%)       1 (1%)       1 (1%)                                             
      Hepatodiaphragmatic Nodule                       5 (6%)       5 (6%)       5 (6%)       6 (8%)       1 (3%)                   
      Hyperplasia                                                   2 (3%)       2 (3%)                                             
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Granulomatous                      1 (1%)                                                                       
      Mixed Cell Focus                                 1 (1%)       1 (1%)       1 (1%)       1 (1%)                                
      Necrosis                                         1 (1%)                    2 (3%)       2 (3%)                                
   Mesentery                                          (6)          (8)          (5)          (9)          (2)                       
      Inflammation, Chronic                            1 (17%)      1 (13%)                                                         
      Artery, Inflammation, Chronic                                                           1 (11%)                               
      Fat, Necrosis                                    4 (67%)      7 (88%)      4 (80%)      6 (67%)      2 (100%)                 
   Pancreas                                           (80)         (80)         (79)         (80)         (30)                      
      Inflammation, Chronic                            2 (3%)       1 (1%)       2 (3%)       2 (3%)       1 (3%)                   
      Acinus, Atrophy                                 26 (33%)     28 (35%)     24 (30%)     20 (25%)      4 (13%)                  
      Acinus, Hyperplasia                                           2 (3%)                                                          
   Stomach, Forestomach                               (80)         (80)         (80)         (80)         (30)                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst Epithelial Inclusion                                                  1 (1%)                                             
      Ulcer                                            2 (3%)                    1 (1%)                                             
   Stomach, Glandular                                 (80)         (80)         (80)         (80)         (30)                      
      Ulcer                                            2 (3%)       2 (3%)       3 (4%)       3 (4%)                                
   Tongue                                                                       (1)          (2)                                    
      Epithelium, Hyperplasia                                                    1 (100%)                                           
      Mucosa, Epithelium, Hyperplasia                                                         2 (100%)                              
   Tooth                                                                                     (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (80)         (80)         (80)         (30)                      
      Degeneration                                     7 (9%)      10 (13%)      8 (10%)      6 (8%)       8 (27%)                  
      Artery, Inflammation, Chronic                                 1 (1%)                                                          
      Atrium, Dilatation                               1 (1%)                                 1 (1%)                                
      Atrium, Thrombosis                               2 (3%)       1 (1%)       2 (3%)                                             
      Intima, Hyperplasia                              1 (1%)                                                                       
      Myocardium, Degeneration                        48 (60%)     55 (69%)     54 (68%)     50 (63%)     12 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (79)         (79)         (80)         (79)         (30)                      
      Hyperplasia                                      9 (11%)     17 (22%)     10 (13%)     13 (16%)      1 (3%)                   
      Vacuolization Cytoplasmic                                                                           10 (33%)                  
   Adrenal Medulla                                    (79)         (80)         (80)         (80)         (28)                      
      Hyperplasia                                     11 (14%)      4 (5%)       6 (8%)      10 (13%)      1 (4%)                   
   Islets, Pancreatic                                 (80)         (80)         (79)         (80)         (30)                      
      Hyperplasia                                      1 (1%)       2 (3%)                    3 (4%)                                
   Pituitary Gland                                    (80)         (80)         (80)         (80)         (30)                      
      Cyst                                             1 (1%)       2 (3%)                    1 (1%)                                
      Pars Distalis, Cyst                                                                                  1 (3%)                   
      Pars Distalis, Degeneration, Focal                            1 (1%)                                                          
      Pars Distalis, Hyperplasia                       3 (4%)       6 (8%)      10 (13%)     11 (14%)      2 (7%)                   
      Pars Distalis, Inflammation, Chronic                          1 (1%)                                                          
      Pars Distalis, Mineralization                    1 (1%)                                                                       
      Pars Intermedia, Hyperplasia                                                                         1 (3%)                   
   Thyroid Gland                                      (80)         (80)         (80)         (79)         (30)                      
      C-Cell, Hyperplasia                             32 (40%)     42 (53%)     48 (60%)     43 (54%)     10 (33%)                  
      Follicle, Dilatation                                          3 (4%)                                                          
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (80)         (80)         (80)         (30)                      
      Aspermia                                                                                             1 (3%)                   
      Hypospermia                                                                1 (1%)                                             
      Inflammation, Chronic Active                                  1 (1%)                                                          
   Preputial Gland                                    (79)         (79)         (77)         (79)         (30)                      
      Hyperplasia                                      1 (1%)       1 (1%)                                                          
      Inflammation, Chronic                           14 (18%)     23 (29%)     14 (18%)     11 (14%)      6 (20%)                  
      Inflammation, Chronic Active                     7 (9%)       5 (6%)       8 (10%)      6 (8%)       9 (30%)                  
   Prostate                                           (80)         (80)         (80)         (80)         (30)                      
      Abscess                                                       1 (1%)                                                          
      Inflammation, Chronic                                                      1 (1%)       2 (3%)                                
      Inflammation, Chronic Active                     2 (3%)       4 (5%)       4 (5%)       6 (8%)       6 (20%)                  
   Seminal Vesicle                                    (80)         (80)         (80)         (80)         (30)                      
      Inflammation, Chronic                                         1 (1%)                    1 (1%)                                
   Testes                                             (80)         (80)         (80)         (80)         (30)                      
      Atrophy                                          1 (1%)                                                                       
      Hypospermia                                                                1 (1%)                                             
      Interstitial Cell, Hyperplasia                   1 (1%)                                                                       
      Seminiferous Tubule, Atrophy                                  2 (3%)       2 (3%)       3 (4%)       1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (78)         (80)         (80)         (79)         (29)                      
      Hyperplasia, Lymphoid                                                                   1 (1%)                                
   Lymph Node, Mesenteric                             (80)         (79)         (80)         (80)         (29)                      
      Cyst                                                                       1 (1%)                                             
      Inflammation, Granulomatous                                   1 (1%)                                                          
   Spleen                                             (79)         (80)         (80)         (80)         (30)                      
      Congestion                                       1 (1%)                                                                       
      Fibrosis                                         3 (4%)       2 (3%)       2 (3%)       6 (8%)                                
      Hematopoietic Cell Proliferation                              1 (1%)       2 (3%)                                             
      Hyperplasia, Lymphoid                                         1 (1%)                                                          
      Infarct                                                       2 (3%)                                                          
      Capsule, Inflammation, Chronic                                                          1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (75)         (75)         (75)         (74)         (29)                      
      Hyperplasia, Cystic                                                        2 (3%)                                             
   Skin                                               (80)         (79)         (80)         (80)         (29)                      
      Abscess                                                       1 (1%)                    1 (1%)                                
      Acanthosis                                                                              1 (1%)                                
      Cyst Epithelial Inclusion                                                  1 (1%)                                             
      Hyperkeratosis                                                                          1 (1%)                                
      Inflammation, Chronic                                         1 (1%)                                                          
      Ulcer                                                         1 (1%)       1 (1%)       2 (3%)                                
      Dermis, Mineralization                           1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (80)         (80)         (80)         (30)                      
      Inflammation, Chronic                                                                   1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (79)         (80)         (80)         (30)                      
      Hydrocephalus                                                 1 (1%)                                                          
      Infarct                                                       1 (1%)                                                          
      Hypothalamus, Compression                        1 (1%)       1 (1%)       2 (3%)       2 (3%)                                
   Peripheral Nerve                                   (95)         (95)         (93)         (95)         (45)                      
      Axon, Degeneration                                            1 (1%)                                                          
   Spinal Cord                                        (95)         (95)         (95)         (94)         (45)                      
      Cyst                                             2 (2%)       1 (1%)                    1 (1%)       1 (2%)                   
      Nerve, Degeneration                                                                     1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (80)         (80)         (80)         (30)                      
      Erythrophagocytosis                                                        1 (1%)                                             
      Hemorrhage                                                                              1 (1%)                                
      Inflammation, Chronic                            3 (4%)       4 (5%)       1 (1%)       3 (4%)                                
   Nose                                               (80)         (80)         (80)         (80)         (30)                      
      Inflammation, Suppurative                        2 (3%)       2 (3%)       4 (5%)       2 (3%)                                
      Nares, Hemorrhage                                1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05100-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:06:56  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)          (1)                                    
      Pinna, Ulcer                                                               1 (100%)                                           
   Eye                                                (8)          (4)          (1)          (1)                                    
      Inflammation, Chronic                            1 (13%)                                                                      
      Phthisis Bulbi                                                             1 (100%)                                           
      Lens, Cataract                                   4 (50%)      3 (75%)                                                         
      Lens, Cataract, Focal                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (80)         (80)         (80)         (30)                      
      Hydronephrosis                                                                          1 (1%)                                
      Infarct                                                       1 (1%)                                                          
      Nephropathy                                     61 (76%)     61 (76%)     60 (75%)     56 (70%)     15 (50%)                  
   Urinary Bladder                                    (80)         (79)         (80)         (80)         (30)                      
      Inflammation, Chronic                                         1 (1%)                                                          
      Mucosa, Ulcer                                                                           1 (1%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------