National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1675

TDMS Study 05100-03 Pathology Tables

NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95
Route: DOSED FEED                                                                                                 Time: 13:07:00




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1330-78-5

       Lock Date:  12/30/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          95           95           95           95           95                        

  Scheduled Sacrifice                                 44           42           45           44           94                        
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            5            5                                     
    Moribund Sacrifice                                14           12           15           18            1                        
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                34           37           30           26                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    95           95           95           94           45                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (80)         (81)         (80)         (80)         (30)                      
   Mesentery                                          (4)          (7)          (4)          (4)          (1)                       
      Histiocytic Sarcoma                                           1 (14%)                                                         
   Tooth                                              (1)          (1)                                                              
      Gingiva, Squamous Cell Carcinoma                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (81)         (80)         (80)         (30)                      
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Rhabdomyoma                                                                1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (80)         (81)         (80)         (80)         (29)                      
      Adenoma                                          1 (1%)       1 (1%)                    1 (1%)                                
   Adrenal Medulla                                    (80)         (81)         (80)         (80)         (29)                      
      Pheochromocytoma Malignant                                                              1 (1%)                                
      Pheochromocytoma Benign                          1 (1%)       2 (2%)       2 (3%)                                             
      Bilateral, Pheochromocytoma Benign                                         1 (1%)                                             
   Islets, Pancreatic                                 (80)         (81)         (80)         (80)         (30)                      
      Adenoma                                                                    1 (1%)                                             
      Carcinoma                                                     1 (1%)                                                          
   Pituitary Gland                                    (80)         (81)         (80)         (80)         (30)                      
      Pars Distalis, Adenoma                          30 (38%)     26 (32%)     27 (34%)     24 (30%)      3 (10%)                  
   Thyroid Gland                                      (80)         (81)         (80)         (80)         (30)                      

                                                             Page   2                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, C-Cell, Adenoma                       1 (1%)                                                                       
      C-Cell, Adenocarcinoma                                                                  1 (1%)                                
      C-Cell, Adenoma                                  9 (11%)      8 (10%)      3 (4%)      11 (14%)                               
      Follicle, Adenoma                                             1 (1%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (80)         (81)         (79)         (79)         (30)                      
      Adenoma                                          1 (1%)       2 (2%)       3 (4%)       3 (4%)                                
      Carcinoma                                        1 (1%)       1 (1%)                                                          
      Bilateral, Adenoma                                            2 (2%)       1 (1%)                                             
   Ovary                                              (80)         (81)         (80)         (80)         (30)                      
      Adenoma                                          1 (1%)                                                                       
      Granulosa Cell Tumor Benign                      1 (1%)                                 1 (1%)                                
      Granulosa-Theca Tumor Malignant                               1 (1%)                                                          
      Granulosa-Theca Tumor Benign                                               1 (1%)                                             
   Uterus                                             (80)         (81)         (80)         (80)         (30)                      
      Adenocarcinoma                                   1 (1%)                                                                       
      Leiomyosarcoma                                                             1 (1%)                                             
      Polyp Stromal                                    7 (9%)       2 (2%)       8 (10%)      9 (11%)      1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)          (2)          (2)          (2)          (1)                       
   Lymph Node, Mandibular                             (80)         (81)         (78)         (80)         (30)                      
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (1%)                                
   Lymph Node, Mesenteric                             (79)         (80)         (80)         (78)         (30)                      
   Spleen                                             (79)         (81)         (80)         (80)         (30)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (77)         (81)         (79)         (79)         (30)                      
      Adenocarcinoma                                                1 (1%)                                                          
      Adenoma                                          2 (3%)       1 (1%)                    1 (1%)                                
      Adenoma, Multiple                                1 (1%)                                                                       
      Fibroadenoma                                    13 (17%)     13 (16%)     18 (23%)     14 (18%)                               
      Fibroadenoma, Multiple                           2 (3%)       3 (4%)       3 (4%)       1 (1%)                                
   Skin                                               (80)         (81)         (80)         (80)         (30)                      
      Fibrosarcoma                                                               2 (3%)                                             

                                                             Page   3                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Squamous Cell Carcinoma                          1 (1%)                                 1 (1%)                                
      Trichoepithelioma                                                                       1 (1%)                                
      Subcutaneous Tissue, Fibroma                                                            1 (1%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (81)         (80)         (80)         (29)                      
      Osteosarcoma                                                                            1 (1%)                                
   Skeletal Muscle                                                 (1)                                                              
      Hemangioma                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (81)         (80)         (80)         (30)                      
      Astrocytoma Malignant                            1 (1%)                                                                       
   Spinal Cord                                        (95)         (93)         (95)         (94)         (45)                      
      Hemangiosarcoma                                               1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (81)         (80)         (80)         (30)                      
      Alveolar/Bronchiolar Adenoma                     1 (1%)                                 1 (1%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (1%)       1 (1%)                                
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (1%)                                
   Nose                                               (80)         (81)         (80)         (80)         (30)                      
      Chondrosarcoma                                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      Pinna, Fibrosarcoma                                                                     1 (100%)                              
   Zymbal's Gland                                                  (2)                                                              
      Carcinoma                                                     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (81)         (80)         (80)         (30)                      
   Urinary Bladder                                    (80)         (81)         (80)         (80)         (30)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(95)        *(95)        *(95)        *(94)        *(45)                      
      Histiocytic Sarcoma                                           1 (1%)                                                          
      Leukemia Mononuclear                             8 (8%)       8 (8%)      13 (14%)     15 (16%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          44          48          48           4                           
     Total Primary Neoplasms                           85          79          89          89           4                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          36          42          44           4                           
     Total Benign Neoplasms                            71          63          71          68           4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          16          18          20                                       
     Total Malignant Neoplasms                         14          16          18          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                  2                                       
     Total Metastatic Neoplasm                                                              2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          95           95           95           95           95                        

  Scheduled Sacrifice                                 44           45           45           45           95                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           16           11           16                                     
    Natural Death                                      5            4            4            6                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                                            
    Terminal Sacrifice                                31           30           35           28                                     

  Animals Examined Microscopically                    95           95           95           95           45                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (78)         (79)         (78)         (79)         (30)                      
      Mast Cell Tumor Benign                           1 (1%)                                 1 (1%)                                
   Liver                                              (79)         (80)         (79)         (80)         (30)                      
      Hepatocellular Adenoma                                        1 (1%)       1 (1%)       1 (1%)                                
   Mesentery                                          (6)          (8)          (5)          (9)          (2)                       
      Liposarcoma                                                                             1 (11%)                               
      Schwannoma Malignant                             1 (17%)                                                                      
   Pancreas                                           (80)         (80)         (79)         (80)         (30)                      
   Stomach, Forestomach                               (80)         (80)         (80)         (80)         (30)                      
      Squamous Cell Papilloma                          1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (80)         (80)         (80)         (30)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (79)         (79)         (80)         (79)         (30)                      
      Adenoma                                          1 (1%)       2 (3%)       2 (3%)       3 (4%)                                
   Adrenal Medulla                                    (79)         (80)         (80)         (80)         (28)                      
      Ganglioneuroma                                   1 (1%)                                                                       
      Pheochromocytoma Malignant                       1 (1%)       1 (1%)                                                          
      Pheochromocytoma Benign                          5 (6%)       7 (9%)       5 (6%)       4 (5%)                                
      Bilateral, Pheochromocytoma Complex              1 (1%)                                                                       
      Bilateral, Pheochromocytoma Benign                                         4 (5%)       1 (1%)                                
   Islets, Pancreatic                                 (80)         (80)         (79)         (80)         (30)                      
      Adenoma                                          3 (4%)                    3 (4%)       1 (1%)       1 (3%)                   
      Carcinoma                                                     1 (1%)                                                          

                                                             Page   7                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (80)         (80)         (80)         (80)         (30)                      
      Pars Distalis, Adenoma                           8 (10%)     11 (14%)     16 (20%)      4 (5%)                                
      Pars Distalis, Adenoma, Multiple                 1 (1%)       1 (1%)                    1 (1%)                                
      Pars Intermedia, Adenoma                                                   1 (1%)                                             
   Thyroid Gland                                      (80)         (80)         (80)         (79)         (30)                      
      Bilateral, C-Cell, Adenoma                       1 (1%)       2 (3%)                    2 (3%)                                
      C-Cell, Adenoma                                 11 (14%)      7 (9%)       6 (8%)       6 (8%)                                
      C-Cell, Carcinoma                                             1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (80)         (80)         (80)         (30)                      
   Preputial Gland                                    (79)         (79)         (77)         (79)         (30)                      
      Adenoma                                          4 (5%)       3 (4%)       3 (4%)       3 (4%)                                
      Carcinoma                                                     1 (1%)                                                          
   Seminal Vesicle                                    (80)         (80)         (80)         (80)         (30)                      
   Testes                                             (80)         (80)         (80)         (80)         (30)                      
      Adenoma                                                       1 (1%)                                                          
      Bilateral, Interstitial Cell, Adenoma           48 (60%)     48 (60%)     47 (59%)     47 (59%)      9 (30%)                  
      Interstitial Cell, Adenoma                      10 (13%)      6 (8%)       8 (10%)     11 (14%)      1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (4)          (6)          (5)          (5)                                    
   Lymph Node, Mandibular                             (78)         (80)         (80)         (79)         (29)                      
   Lymph Node, Mesenteric                             (80)         (79)         (80)         (80)         (29)                      
   Spleen                                             (79)         (80)         (80)         (80)         (30)                      
      Sarcoma                                          1 (1%)                                 1 (1%)                                
   Thymus                                             (79)         (77)         (77)         (79)         (30)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (75)         (75)         (75)         (74)         (29)                      
      Fibroadenoma                                                  3 (4%)       2 (3%)       2 (3%)                                
   Skin                                               (80)         (79)         (80)         (80)         (29)                      
      Basal Cell Adenoma                               1 (1%)                                                                       
      Basosquamous Tumor Benign                        1 (1%)                                                                       
      Fibroma                                          1 (1%)                                                                       
      Keratoacanthoma                                  2 (3%)                                                                       

                                                             Page   8                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Squamous Cell Carcinoma                          1 (1%)                                                                       
      Squamous Cell Papilloma                                       1 (1%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (1%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                                 1 (1%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (1%)                                                                       
      Subcutaneous Tissue, Lipoma                                                             1 (1%)                                
      Subcutaneous Tissue, Sarcoma                                               1 (1%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)          (1)                                                 
      Sarcoma                                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (79)         (80)         (80)         (30)                      
      Astrocytoma Benign                               1 (1%)                                                                       
      Granular Cell Tumor Benign                       1 (1%)                                                                       
      Oligodendroglioma Benign                                                   1 (1%)                                             
   Peripheral Nerve                                   (95)         (95)         (93)         (95)         (45)                      
   Spinal Cord                                        (95)         (95)         (95)         (94)         (45)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (80)         (80)         (80)         (80)         (30)                      
      Alveolar/Bronchiolar Carcinoma                   1 (1%)                                                                       
   Nose                                               (80)         (80)         (80)         (80)         (30)                      
      Squamous Cell Carcinoma                                                                 1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)          (1)                                    
      Pinna, Fibrosarcoma                                                                     1 (100%)                              
   Zymbal's Gland                                     (1)          (1)          (1)          (1)                                    
      Carcinoma                                        1 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (80)         (80)         (80)         (80)         (30)                      
   Urinary Bladder                                    (80)         (79)         (80)         (80)         (30)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(95)        *(95)        *(95)        *(95)        *(45)                      
      Leukemia Mononuclear                            20 (21%)     18 (19%)     16 (17%)     20 (21%)      2 (4%)                   
      Mesothelioma Benign                                                                     1 (1%)                                
      Mesothelioma Malignant                           1 (1%)                    1 (1%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05100-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 13:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        75 PPM       150 PPM      300 PPM      600 PPM                      
                                                                                                       23 STOP                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          59          58          59          11                           
     Total Primary Neoplasms                          133         118         118         115          14                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 59          58          57          59          10                           
     Total Benign Neoplasms                           102          94          99          89          12                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          24          19          24           2                           
     Total Malignant Neoplasms                         31          24          19          26           2                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.