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TDMS Study 05100-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/10/95       
EXPERIMENT: 05100 TEST: 03                                                                                     TIME: 14:27:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-45050                              ROUTE: DOSED FEED                                              NTP C#: 10277D       
PATHOLOGIST: M. RYAN                                                                                           CAS: 1330-78-5       
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/10/95       
EXPERIMENT: 05100 TEST: 03                                                                                     TIME: 14:27:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45050                              ROUTE: DOSED FEED                                              NTP C#: 10277D       
PATHOLOGIST: M. RYAN                                                                                           CAS: 1330-78-5       




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     TRICRESYL PHOSPHATE                                 DATE: 11/10/95       
EXPERIMENT: 05100 TEST: 03                                                                                     TIME: 14:27:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45050                              ROUTE: DOSED FEED                                              NTP C#: 10277D       
PATHOLOGIST: M. RYAN                                                                                           CAS: 1330-78-5       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF TRICRESYL PHOSPHATE

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
              Testes                        Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   1
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/79 (1%)          2/79 (3%)          2/80 (3%)          3/79 (4%)          0/30 (0%)            |
|ADJUSTED (b)           |         3.2%               6.1%               5.3%              11.1%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        1/31 (3%)          1/29 (3%)          1/35 (3%)          3/27 (11%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            690                701                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.272            P=0.478            P=0.534            P=0.256              (e)                |
|INCIDENTAL TUMOR       |        P=0.275            P=0.461            P=0.440            P=0.256              (e)                |
|LOGISTIC REGRESSION    |        P=0.287            P=0.477            P=0.514            P=0.256              (e)                |
|COCHRAN-ARMITAGE       |        P=0.605N                                                                                         |
|FISHER EXACT           |                           P=0.500            P=0.505            P=0.310            P=0.725N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        5/79 (6%)          7/80 (9%)          9/80 (11%)         5/80 (6%)          0/28 (0%)            |
|ADJUSTED (b)           |        16.1%              20.6%              24.3%              16.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/8 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        5/31 (16%)         5/30 (17%)         7/35 (20%)         4/28 (14%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            586                722                656                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.584            P=0.357            P=0.263            P=0.568              (e)                |
|INCIDENTAL TUMOR       |        P=0.605            P=0.379            P=0.187            P=0.566              (e)                |
|LOGISTIC REGRESSION    |        P=0.601N           P=0.357            P=0.247            P=0.580              (e)                |
|COCHRAN-ARMITAGE       |        P=0.140N                                                                                         |
|FISHER EXACT           |                           P=0.392            P=0.208            P=0.619N           P=0.212N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   2
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        7/79 (9%)          8/80 (10%)         9/80 (11%)         5/80 (6%)          0/28 (0%)            |
|ADJUSTED (b)           |        22.6%              22.7%              24.3%              16.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/8 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        7/31 (23%)         5/30 (17%)         7/35 (20%)         4/28 (14%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            586                722                656                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.413N           P=0.472            P=0.493            P=0.450N             (e)                |
|INCIDENTAL TUMOR       |        P=0.394N           P=0.486            P=0.400            P=0.451N             (e)                |
|LOGISTIC REGRESSION    |        P=0.362N           P=0.476            P=0.481            P=0.441N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.062N                                                                                         |
|FISHER EXACT           |                           P=0.510            P=0.407            P=0.374N           P=0.111N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        4/79 (5%)          3/79 (4%)          3/77 (4%)          3/79 (4%)          0/30 (0%)            |
|ADJUSTED (b)           |        11.6%               9.1%               8.6%               8.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/8 (0%)           0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          1/9 (11%)          0/10 (0%)            |
|TERMINAL (d)           |        3/31 (10%)         2/29 (7%)          3/35 (9%)          1/28 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         558                614                729 (T)            455 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.455N           P=0.529N           P=0.448N           P=0.550N             (e)                |
|INCIDENTAL TUMOR       |        P=0.398N           P=0.440N           P=0.426N           P=0.481N             (e)                |
|LOGISTIC REGRESSION    |        P=0.431N           P=0.521N           P=0.499N           P=0.503N           P=0.845N             |
|COCHRAN-ARMITAGE       |        P=0.197N                                                                                         |
|FISHER EXACT           |                           P=0.500N           P=0.514N           P=0.500N           P=0.270N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   3
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        4/79 (5%)          4/79 (5%)          3/77 (4%)          3/79 (4%)          0/30 (0%)            |
|ADJUSTED (b)           |        11.6%              12.4%               8.6%               8.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/8 (0%)           0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          1/9 (11%)          0/10 (0%)            |
|TERMINAL (d)           |        3/31 (10%)         3/29 (10%)         3/35 (9%)          1/28 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         558                614                729 (T)            455 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.408N           P=0.612            P=0.448N           P=0.550N             (e)                |
|INCIDENTAL TUMOR       |        P=0.354N           P=0.597N           P=0.426N           P=0.481N             (e)                |
|LOGISTIC REGRESSION    |        P=0.386N           P=0.621            P=0.499N           P=0.503N           P=0.845N             |
|COCHRAN-ARMITAGE       |        P=0.164N                                                                                         |
|FISHER EXACT           |                           P=0.640N           P=0.514N           P=0.500N           P=0.270N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/80 (4%)          0/80 (0%)          3/79 (4%)          1/80 (1%)          1/30 (3%)            |
|ADJUSTED (b)           |         7.5%               0.0%               8.3%               3.6%              10.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|TERMINAL (d)           |        1/32 (3%)          0/30 (0%)          2/35 (6%)          1/28 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            ---                722                729 (T)            455 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.509            P=0.133N           P=0.626N           P=0.349N           P=0.766              |
|INCIDENTAL TUMOR       |        P=0.512            P=0.140N           P=0.565            P=0.340N           P=0.766              |
|LOGISTIC REGRESSION    |        P=0.442            P=0.125N           P=0.657            P=0.312N           P=0.572              |
|COCHRAN-ARMITAGE       |        P=0.607N                                                                                         |
|FISHER EXACT           |                           P=0.123N           P=0.653            P=0.310N           P=0.701N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   4
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/80 (4%)          1/80 (1%)          3/79 (4%)          1/80 (1%)          1/30 (3%)            |
|ADJUSTED (b)           |         7.5%               3.3%               8.3%               3.6%              10.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|TERMINAL (d)           |        1/32 (3%)          1/30 (3%)          2/35 (6%)          1/28 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            729 (T)            722                729 (T)            455 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.560            P=0.328N           P=0.626N           P=0.349N           P=0.766              |
|INCIDENTAL TUMOR       |        P=0.561            P=0.337N           P=0.565            P=0.340N           P=0.766              |
|LOGISTIC REGRESSION    |        P=0.500            P=0.315N           P=0.657            P=0.312N           P=0.572              |
|COCHRAN-ARMITAGE       |        P=0.525N                                                                                         |
|FISHER EXACT           |                           P=0.310N           P=0.653            P=0.310N           P=0.701N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         3.1%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        1/32 (3%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.584N           P=0.513N           P=0.482N           P=0.527N             (e)                |
|INCIDENTAL TUMOR       |        P=0.584N           P=0.513N           P=0.482N           P=0.527N             (e)                |
|LOGISTIC REGRESSION    |        P=0.584N           P=0.513N           P=0.482N           P=0.527N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.449N                                                                                         |
|FISHER EXACT           |                           P=0.500N           P=0.500N           P=0.500N           P=0.727N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   5
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   6
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          3/80 (4%)          2/80 (3%)          2/80 (3%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               7.5%               5.7%               5.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          1/30 (3%)          2/35 (6%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                498                729 (T)            614                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.409            P=0.119            P=0.258            P=0.232              (e)                |
|INCIDENTAL TUMOR       |        P=0.473            P=0.152            P=0.258            P=0.323              (e)                |
|LOGISTIC REGRESSION    |        P=0.532            P=0.119            P=0.258            P=0.234              (e)                |
|COCHRAN-ARMITAGE       |        P=0.567N                                                                                         |
|FISHER EXACT           |                           P=0.123            P=0.248            P=0.248              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          3/80 (4%)          2/80 (3%)          2/80 (3%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               7.5%               5.7%               5.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          1/30 (3%)          2/35 (6%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                498                729 (T)            614                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.409            P=0.119            P=0.258            P=0.232              (e)                |
|INCIDENTAL TUMOR       |        P=0.473            P=0.152            P=0.258            P=0.323              (e)                |
|LOGISTIC REGRESSION    |        P=0.532            P=0.119            P=0.258            P=0.234              (e)                |
|COCHRAN-ARMITAGE       |        P=0.567N                                                                                         |
|FISHER EXACT           |                           P=0.123            P=0.248            P=0.248              (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   7
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          3/80 (4%)          2/80 (3%)          2/80 (3%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               7.5%               5.7%               5.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          1/30 (3%)          2/35 (6%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                498                729 (T)            614                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.409            P=0.119            P=0.258            P=0.232              (e)                |
|INCIDENTAL TUMOR       |        P=0.473            P=0.152            P=0.258            P=0.323              (e)                |
|LOGISTIC REGRESSION    |        P=0.532            P=0.119            P=0.258            P=0.234              (e)                |
|COCHRAN-ARMITAGE       |        P=0.567N                                                                                         |
|FISHER EXACT           |                           P=0.123            P=0.248            P=0.248              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        9/80 (11%)        12/80 (15%)        16/80 (20%)         5/80 (6%)          0/30 (0%)            |
|ADJUSTED (b)           |        24.1%              38.1%              36.9%              14.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        1/10 (10%)         0/10 (0%)          2/10 (20%)         1/10 (10%)         0/10 (0%)            |
|TERMINAL (d)           |        6/32 (19%)        11/30 (37%)        10/35 (29%)         3/28 (11%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            614                454                455 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.131N           P=0.256            P=0.123            P=0.260N           P=0.500N             |
|INCIDENTAL TUMOR       |        P=0.126N           P=0.270            P=0.089            P=0.276N           P=0.500N             |
|LOGISTIC REGRESSION    |        P=0.112N           P=0.267            P=0.085            P=0.207N           P=0.591N             |
|COCHRAN-ARMITAGE       |        P=0.014N*                                                                                        |
|FISHER EXACT           |                           P=0.320            P=0.095            P=0.201N           P=0.050N*            |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   8
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma or Basosquamous Tumor Benign                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         6.3%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        2/32 (6%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|INCIDENTAL TUMOR       |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|LOGISTIC REGRESSION    |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.209N                                                                                         |
|FISHER EXACT           |                           P=0.248N           P=0.248N           P=0.248N           P=0.527N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         6.3%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        2/32 (6%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|INCIDENTAL TUMOR       |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|LOGISTIC REGRESSION    |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.209N                                                                                         |
|FISHER EXACT           |                           P=0.248N           P=0.248N           P=0.248N           P=0.527N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE   9
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         6.3%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        2/32 (6%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|INCIDENTAL TUMOR       |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|LOGISTIC REGRESSION    |        P=0.246N           P=0.252N           P=0.219N           P=0.268N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.209N                                                                                         |
|FISHER EXACT           |                           P=0.248N           P=0.248N           P=0.248N           P=0.527N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        4/80 (5%)          1/80 (1%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |        11.8%               1.7%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        3/32 (9%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         701                455 (I)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.046N*          P=0.202N           P=0.055N           P=0.083N             (e)                |
|INCIDENTAL TUMOR       |        P=0.049N*          P=0.207N           P=0.077N           P=0.081N             (e)                |
|LOGISTIC REGRESSION    |        P=0.044N*          P=0.189N           P=0.059N           P=0.076N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.046N*                                                                                        |
|FISHER EXACT           |                           P=0.184N           P=0.060N           P=0.060N           P=0.274N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  10
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/80 (4%)          1/80 (1%)          1/80 (1%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         8.8%               3.0%               2.4%               3.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        2/32 (6%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         701                701                624                711                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.365N           P=0.339N           P=0.292N           P=0.356N             (e)                |
|INCIDENTAL TUMOR       |        P=0.329N           P=0.354N           P=0.336N           P=0.347N             (e)                |
|LOGISTIC REGRESSION    |        P=0.323N           P=0.326N           P=0.306N           P=0.336N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.194N                                                                                         |
|FISHER EXACT           |                           P=0.310N           P=0.310N           P=0.310N           P=0.381N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          0/80 (0%)          0/80 (0%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         3.1%               0.0%               0.0%               3.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        1/32 (3%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                711                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.755            P=0.513N           P=0.482N           P=0.731              (e)                |
|INCIDENTAL TUMOR       |        P=0.740            P=0.513N           P=0.482N           P=0.735              (e)                |
|LOGISTIC REGRESSION    |        P=0.757            P=0.513N           P=0.482N           P=0.742              (e)                |
|COCHRAN-ARMITAGE       |        P=0.674N                                                                                         |
|FISHER EXACT           |                           P=0.500N           P=0.500N           P=0.752N           P=0.727N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  11
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          0/80 (0%)          1/80 (1%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         5.7%               0.0%               2.4%               3.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        1/32 (3%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         701                ---                624                711                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.656N           P=0.260N           P=0.489N           P=0.546N             (e)                |
|INCIDENTAL TUMOR       |        P=0.595N           P=0.269N           P=0.552N           P=0.538N             (e)                |
|LOGISTIC REGRESSION    |        P=0.593N           P=0.251N           P=0.502N           P=0.526N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.399N                                                                                         |
|FISHER EXACT           |                           P=0.248N           P=0.500N           P=0.500N           P=0.527N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         5.7%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        1/32 (3%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         701                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.248N           P=0.260N           P=0.224N           P=0.271N             (e)                |
|INCIDENTAL TUMOR       |        P=0.260N           P=0.269N           P=0.312N           P=0.265N             (e)                |
|LOGISTIC REGRESSION    |        P=0.241N           P=0.251N           P=0.236N           P=0.254N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.209N                                                                                         |
|FISHER EXACT           |                           P=0.248N           P=0.248N           P=0.248N           P=0.527N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  12
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/80 (4%)          1/80 (1%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         8.8%               1.7%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        2/32 (6%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         701                455 (I)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.089N           P=0.329N           P=0.110N           P=0.148N             (e)                |
|INCIDENTAL TUMOR       |        P=0.092N           P=0.337N           P=0.154N           P=0.145N             (e)                |
|LOGISTIC REGRESSION    |        P=0.088N           P=0.314N           P=0.117N           P=0.137N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.085N                                                                                         |
|FISHER EXACT           |                           P=0.310N           P=0.123N           P=0.123N           P=0.381N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          1/80 (1%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         5.7%               1.7%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        1/32 (3%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         701                455 (I)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.165N           P=0.521N           P=0.224N           P=0.271N             (e)                |
|INCIDENTAL TUMOR       |        P=0.171N           P=0.530N           P=0.312N           P=0.265N             (e)                |
|LOGISTIC REGRESSION    |        P=0.174N           P=0.506N           P=0.236N           P=0.254N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.160N                                                                                         |
|FISHER EXACT           |                           P=0.500N           P=0.248N           P=0.248N           P=0.527N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  13
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       58/80 (73%)        55/80 (69%)        55/80 (69%)        58/80 (73%)        10/30 (33%)           |
|ADJUSTED (b)           |       100.0%              94.8%             100.0%             100.0%             100.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|       10/10 (100%)       10/10 (100%)        9/10 (90%)         9/10 (90%)        10/10 (100%)          |
|TERMINAL (d)           |       32/32 (100%)       27/30 (90%)        35/35 (100%)       28/28 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            455 (I)            455 (I)            455 (I)            455 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.217            P=0.561N           P=0.168N           P=0.240              (e)                |
|INCIDENTAL TUMOR       |        P=0.443            P=0.362N           P=0.437N           P=0.705              (e)                |
|LOGISTIC REGRESSION    |        P=0.188            P=0.326N           P=0.352N           P=0.640N           P=0.326              |
|COCHRAN-ARMITAGE       |        P=0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.364N           P=0.364N           P=0.570N           P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       12/80 (15%)         9/80 (11%)         6/80 (8%)          8/79 (10%)         0/30 (0%)            |
|ADJUSTED (b)           |        32.8%              23.0%              17.1%              23.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        8/32 (25%)         4/30 (13%)         6/35 (17%)         5/28 (18%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         647                586                729 (T)            589                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.276N           P=0.374N           P=0.073N           P=0.329N             (e)                |
|INCIDENTAL TUMOR       |        P=0.195N           P=0.293N           P=0.135N           P=0.252N             (e)                |
|LOGISTIC REGRESSION    |        P=0.176N           P=0.269N           P=0.088N           P=0.271N           P=0.957N             |
|COCHRAN-ARMITAGE       |        P=0.025N*                                                                                        |
|FISHER EXACT           |                           P=0.320N           P=0.105N           P=0.246N           P=0.017N*            |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  14
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       12/80 (15%)        10/80 (13%)         6/80 (8%)          8/79 (10%)         0/30 (0%)            |
|ADJUSTED (b)           |        32.8%              26.0%              17.1%              23.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        8/32 (25%)         5/30 (17%)         6/35 (17%)         5/28 (18%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         647                586                729 (T)            589                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.250N           P=0.467N           P=0.073N           P=0.329N             (e)                |
|INCIDENTAL TUMOR       |        P=0.174N           P=0.388N           P=0.135N           P=0.252N             (e)                |
|LOGISTIC REGRESSION    |        P=0.157N           P=0.366N           P=0.088N           P=0.271N           P=0.957N             |
|COCHRAN-ARMITAGE       |        P=0.021N*                                                                                        |
|FISHER EXACT           |                           P=0.409N           P=0.105N           P=0.246N           P=0.017N*            |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/80 (0%)          0/80 (0%)          0/79 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  15
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |                                                                                                         |
|ADJUSTED (b)           |                                                                                                         |
|INTERIM SACRIFICE 1 (c)|                                                                                                         |
|INTERIM SACRIFICE 2 (c)|                                                                                                         |
|INTERIM SACRIFICE 3 (c)|                                                                                                         |
|TERMINAL (d)           |                                                                                                         |
|FIRST INCIDENCE (DAYS) |                                                                                                         |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |                                                                                                         |
|INCIDENTAL TUMOR       |                                                                                                         |
|LOGISTIC REGRESSION    |                                                                                                         |
|COCHRAN-ARMITAGE       |                                                                                                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          1/80 (1%)          1/80 (1%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         2.0%               3.3%               2.1%               3.1%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          1/30 (3%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         478                729 (T)            488                702                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.746            P=0.749            P=0.756            P=0.750              (e)                |
|INCIDENTAL TUMOR       |        P=0.710            P=0.753            P=0.712N           P=0.705              (e)                |
|LOGISTIC REGRESSION    |        P=0.574N           P=0.760            P=0.761N           P=0.761            P=0.737N             |
|COCHRAN-ARMITAGE       |        P=0.487N                                                                                         |
|FISHER EXACT           |                           P=0.752N           P=0.752N           P=0.752N           P=0.727N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  16
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/80 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|TERMINAL (d)           |        0/32 (0%)          0/30 (0%)          0/35 (0%)          0/28 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       20/80 (25%)        18/80 (23%)        16/80 (20%)        20/80 (25%)         2/30 (7%)            |
|ADJUSTED (b)           |        44.3%              39.5%              37.7%              44.9%              14.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 3 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|TERMINAL (d)           |        8/32 (25%)         4/30 (13%)         9/35 (26%)         5/28 (18%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         486                455 (I)            553                578                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.197            P=0.514N           P=0.250N           P=0.441            P=0.251              |
|INCIDENTAL TUMOR       |        P=0.352            P=0.405N           P=0.447N           P=0.382N           P=0.251              |
|LOGISTIC REGRESSION    |        P=0.503            P=0.285N           P=0.415N           P=0.239N           P=0.682N             |
|COCHRAN-ARMITAGE       |        P=0.069N                                                                                         |
|FISHER EXACT           |                           P=0.426N           P=0.285N           P=0.572N           P=0.025N*            |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  17
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       59/80 (74%)        58/80 (73%)        57/80 (71%)        59/80 (74%)        10/30 (33%)           |
|ADJUSTED (b)           |       100.0%             100.0%             100.0%             100.0%             100.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|       10/10 (100%)       10/10 (100%)        9/10 (90%)         9/10 (90%)        10/10 (100%)          |
|TERMINAL (d)           |       32/32 (100%)       30/30 (100%)       35/35 (100%)       28/28 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            455 (I)            454                455 (I)            455 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.253            P=0.431            P=0.234N           P=0.247              (e)                |
|INCIDENTAL TUMOR       |        P=0.522            P=0.785            P=0.570N           P=0.716N             (e)                |
|LOGISTIC REGRESSION    |        P=0.316            P=0.717N           P=0.515N           P=0.739N           P=0.520              |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.500N           P=0.430N           P=0.571N           P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       29/80 (36%)        24/80 (30%)        19/80 (24%)        24/80 (30%)         2/30 (7%)            |
|ADJUSTED (b)           |        59.6%              51.0%              42.7%              51.1%              14.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 3 (c)|        1/10 (10%)         1/10 (10%)         0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|TERMINAL (d)           |       13/32 (41%)         8/30 (27%)        10/35 (29%)         6/28 (21%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            455 (I)            488                542                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.541            P=0.360N           P=0.057N           P=0.404N           P=0.512              |
|INCIDENTAL TUMOR       |        P=0.309N           P=0.208N           P=0.068N           P=0.081N           P=0.512              |
|LOGISTIC REGRESSION    |        P=0.189N           P=0.152N           P=0.081N           P=0.040N*          P=0.393N             |
|COCHRAN-ARMITAGE       |        P=0.006N**                                                                                       |
|FISHER EXACT           |                           P=0.251N           P=0.060N           P=0.251N           P=0.001N**           |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  18
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       60/80 (75%)        59/80 (74%)        58/80 (73%)        59/80 (74%)        11/30 (37%)           |
|ADJUSTED (b)           |       100.0%             100.0%             100.0%             100.0%             100.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 3 (c)|       10/10 (100%)       10/10 (100%)        9/10 (90%)         9/10 (90%)        10/10 (100%)          |
|TERMINAL (d)           |       32/32 (100%)       30/30 (100%)       35/35 (100%)       28/28 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         455 (I)            455 (I)            454                455 (I)            273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.203            P=0.432            P=0.242N           P=0.303            P=0.521              |
|INCIDENTAL TUMOR       |        P=0.273              (e)              P=0.500N           P=0.500N           P=0.521              |
|LOGISTIC REGRESSION    |        P=0.280              (e)              P=0.522N           P=0.500N           P=0.521              |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.500N           P=0.429N           P=0.500N           P<0.001N**           |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  19
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          1/81 (1%)          0/80 (0%)          1/80 (1%)          0/29 (0%)            |
|ADJUSTED (b)           |         2.9%               2.6%               0.0%               3.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/8 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          1/38 (3%)          0/30 (0%)          1/26 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            ---                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.763            P=0.737N           P=0.525N           P=0.701              (e)                |
|INCIDENTAL TUMOR       |        P=0.763            P=0.737N           P=0.525N           P=0.701              (e)                |
|LOGISTIC REGRESSION    |        P=0.763            P=0.737N           P=0.525N           P=0.701              (e)                |
|COCHRAN-ARMITAGE       |        P=0.521N                                                                                         |
|FISHER EXACT           |                           P=0.748N           P=0.500N           P=0.752N           P=0.734N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          2/81 (2%)          3/80 (4%)          0/80 (0%)          0/29 (0%)            |
|ADJUSTED (b)           |         2.9%               4.7%              10.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/8 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          1/38 (3%)          3/30 (10%)         0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            620                729 (T)            ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.541N           P=0.544            P=0.261            P=0.553N             (e)                |
|INCIDENTAL TUMOR       |        P=0.539N           P=0.432            P=0.261            P=0.554N             (e)                |
|LOGISTIC REGRESSION    |        P=0.455N           P=0.526            P=0.261            P=0.554N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.253N                                                                                         |
|FISHER EXACT           |                           P=0.505            P=0.310            P=0.500N           P=0.734N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  20
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          2/81 (2%)          3/80 (4%)          1/80 (1%)          0/29 (0%)            |
|ADJUSTED (b)           |         2.9%               4.7%              10.0%               2.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/8 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          1/38 (3%)          3/30 (10%)         0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            620                729 (T)            625                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.646            P=0.544            P=0.261            P=0.734              (e)                |
|INCIDENTAL TUMOR       |        P=0.648            P=0.432            P=0.261            P=0.713              (e)                |
|LOGISTIC REGRESSION    |        P=0.652N           P=0.526            P=0.261            P=0.756              (e)                |
|COCHRAN-ARMITAGE       |        P=0.375N                                                                                         |
|FISHER EXACT           |                           P=0.505            P=0.310            P=0.752N           P=0.734N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          4/81 (5%)          4/79 (5%)          3/79 (4%)          0/30 (0%)            |
|ADJUSTED (b)           |         2.9%              10.5%              12.8%              11.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          4/38 (11%)         3/29 (10%)         3/26 (12%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            705                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.258            P=0.214            P=0.146            P=0.214              (e)                |
|INCIDENTAL TUMOR       |        P=0.303            P=0.214            P=0.191            P=0.214              (e)                |
|LOGISTIC REGRESSION    |        P=0.304            P=0.214            P=0.175            P=0.214              (e)                |
|COCHRAN-ARMITAGE       |        P=0.431N                                                                                         |
|FISHER EXACT           |                           P=0.187            P=0.180            P=0.305            P=0.727N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  21
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/80 (3%)          5/81 (6%)          4/79 (5%)          3/79 (4%)          0/30 (0%)            |
|ADJUSTED (b)           |         5.9%              13.2%              12.8%              11.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        2/34 (6%)          5/38 (13%)         3/29 (10%)         3/26 (12%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            705                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.428            P=0.262            P=0.280            P=0.378              (e)                |
|INCIDENTAL TUMOR       |        P=0.477            P=0.262            P=0.342            P=0.378              (e)                |
|LOGISTIC REGRESSION    |        P=0.482            P=0.262            P=0.328            P=0.378              (e)                |
|COCHRAN-ARMITAGE       |        P=0.277N                                                                                         |
|FISHER EXACT           |                           P=0.226            P=0.335            P=0.494            P=0.527N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          1/80 (1%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               3.3%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          1/30 (3%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                729 (T)            ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.868              (e)              P=0.475              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.868              (e)              P=0.475              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.868              (e)              P=0.475              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.778N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.500              (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  22
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          1/81 (1%)          1/80 (1%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               2.6%               3.3%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          1/30 (3%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                712                729 (T)            ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.816N           P=0.516            P=0.475              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.715N           P=0.567            P=0.475              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.787N           P=0.520            P=0.475              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.555N                                                                                         |
|FISHER EXACT           |                           P=0.503            P=0.500              (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          0/81 (0%)          1/80 (1%)          2/80 (3%)          0/30 (0%)            |
|ADJUSTED (b)           |         2.9%               0.0%               2.3%               7.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          0/38 (0%)          0/30 (0%)          2/26 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                642                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.295            P=0.478N           P=0.760            P=0.406              (e)                |
|INCIDENTAL TUMOR       |        P=0.303            P=0.478N           P=0.729            P=0.406              (e)                |
|LOGISTIC REGRESSION    |        P=0.369            P=0.478N           P=0.752N           P=0.406              (e)                |
|COCHRAN-ARMITAGE       |        P=0.600                                                                                          |
|FISHER EXACT           |                           P=0.497N           P=0.752N           P=0.500            P=0.727N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  23
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/80 (4%)          1/81 (1%)          0/80 (0%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         8.8%               1.2%               0.0%               3.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        3/34 (9%)          0/38 (0%)          0/30 (0%)          1/26 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)             92 (I)            ---                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.280N           P=0.277N           P=0.143N           P=0.405N             (e)                |
|INCIDENTAL TUMOR       |        P=0.280N           P=0.278N           P=0.143N           P=0.405N             (e)                |
|LOGISTIC REGRESSION    |        P=0.221N           P=0.300N           P=0.143N           P=0.405N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.188N                                                                                         |
|FISHER EXACT           |                           P=0.305N           P=0.123N           P=0.310N           P=0.381N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/80 (4%)          2/81 (2%)          0/80 (0%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         8.8%               2.7%               0.0%               3.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        3/34 (9%)          0/38 (0%)          0/30 (0%)          1/26 (4%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)             92 (I)            ---                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.188N           P=0.470N           P=0.143N           P=0.405N             (e)                |
|INCIDENTAL TUMOR       |        P=0.188N           P=0.470N           P=0.143N           P=0.405N             (e)                |
|LOGISTIC REGRESSION    |        P=0.154N           P=0.495N           P=0.143N           P=0.405N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.148N                                                                                         |
|FISHER EXACT           |                           P=0.494N           P=0.123N           P=0.310N           P=0.381N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  24
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       15/80 (19%)        16/81 (20%)        21/80 (26%)        15/80 (19%)         0/30 (0%)            |
|ADJUSTED (b)           |        36.0%              37.9%              52.1%              42.9%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        8/34 (24%)        12/38 (32%)        11/30 (37%)         8/26 (31%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         557                653                592                564                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.238            P=0.522N           P=0.141            P=0.391              (e)                |
|INCIDENTAL TUMOR       |        P=0.420N           P=0.560            P=0.391            P=0.482N             (e)                |
|LOGISTIC REGRESSION    |        P=0.522N           P=0.535            P=0.276            P=0.479N           P=0.398N             |
|COCHRAN-ARMITAGE       |        P=0.023N*                                                                                        |
|FISHER EXACT           |                           P=0.515            P=0.172            P=0.580N           P=0.006N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       18/80 (23%)        17/81 (21%)        21/80 (26%)        16/80 (20%)         0/30 (0%)            |
|ADJUSTED (b)           |        43.4%              38.7%              52.1%              46.1%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |       11/34 (32%)        12/38 (32%)        11/30 (37%)         9/26 (35%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         557                 92 (I)            592                564                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.387            P=0.360N           P=0.290            P=0.505              (e)                |
|INCIDENTAL TUMOR       |        P=0.266N           P=0.429N           P=0.537N           P=0.357N             (e)                |
|LOGISTIC REGRESSION    |        P=0.359N           P=0.409N           P=0.523            P=0.328N           P=0.415N             |
|COCHRAN-ARMITAGE       |        P=0.010N*                                                                                        |
|FISHER EXACT           |                           P=0.483N           P=0.356            P=0.423N           P=0.002N**           |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  25
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       18/80 (23%)        18/81 (22%)        21/80 (26%)        16/80 (20%)         0/30 (0%)            |
|ADJUSTED (b)           |        43.4%              39.6%              52.1%              46.1%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |       11/34 (32%)        12/38 (32%)        11/30 (37%)         9/26 (35%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         557                 92 (I)            592                564                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.459            P=0.434N           P=0.290            P=0.505              (e)                |
|INCIDENTAL TUMOR       |        P=0.213N           P=0.513N           P=0.537N           P=0.357N             (e)                |
|LOGISTIC REGRESSION    |        P=0.294N           P=0.501N           P=0.523            P=0.328N           P=0.415N             |
|COCHRAN-ARMITAGE       |        P=0.009N**                                                                                       |
|FISHER EXACT           |                           P=0.558N           P=0.356            P=0.423N           P=0.002N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       30/80 (38%)        26/81 (32%)        27/80 (34%)        24/80 (30%)         3/30 (10%)           |
|ADJUSTED (b)           |        66.7%              56.2%              63.0%              58.7%              33.3%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           1/8 (13%)          2/10 (20%)         1/10 (10%)         3/9 (33%)            |
|TERMINAL (d)           |       19/34 (56%)        18/38 (47%)        15/30 (50%)        11/26 (42%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         553                456 (I)            456 (I)            353                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.256            P=0.160N           P=0.465N           P=0.454N           P=0.109              |
|INCIDENTAL TUMOR       |        P=0.394N           P=0.232N           P=0.124N           P=0.088N           P=0.109              |
|LOGISTIC REGRESSION    |        P=0.460N           P=0.287N           P=0.223N           P=0.153N           P=0.285              |
|COCHRAN-ARMITAGE       |        P=0.006N**                                                                                       |
|FISHER EXACT           |                           P=0.290N           P=0.371N           P=0.202N           P=0.003N**           |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  26
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma or Basosquamous Tumor Benign                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          0/80 (0%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               1.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          1/10 (10%)         0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                456 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.646              (e)                (e)              P=0.521              (e)                |
|INCIDENTAL TUMOR       |        P=0.646              (e)                (e)              P=0.521              (e)                |
|LOGISTIC REGRESSION    |        P=0.569              (e)                (e)              P=0.503              (e)                |
|COCHRAN-ARMITAGE       |        P=0.550                                                                                          |
|FISHER EXACT           |                             (e)                (e)              P=0.500              (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  27
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          0/80 (0%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               1.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          1/10 (10%)         0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                456 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.646              (e)                (e)              P=0.521              (e)                |
|INCIDENTAL TUMOR       |        P=0.646              (e)                (e)              P=0.521              (e)                |
|LOGISTIC REGRESSION    |        P=0.569              (e)                (e)              P=0.503              (e)                |
|COCHRAN-ARMITAGE       |        P=0.550                                                                                          |
|FISHER EXACT           |                             (e)                (e)              P=0.500              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          0/81 (0%)          0/80 (0%)          2/80 (3%)          0/30 (0%)            |
|ADJUSTED (b)           |         2.9%               0.0%               0.0%               5.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          1/10 (10%)         0/9 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                456 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.527            P=0.478N           P=0.525N           P=0.456              (e)                |
|INCIDENTAL TUMOR       |        P=0.604            P=0.478N           P=0.525N           P=0.594              (e)                |
|LOGISTIC REGRESSION    |        P=0.487            P=0.478N           P=0.525N           P=0.493              (e)                |
|COCHRAN-ARMITAGE       |        P=0.586                                                                                          |
|FISHER EXACT           |                           P=0.497N           P=0.500N           P=0.500            P=0.727N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  28
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          3/80 (4%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               6.3%               2.9%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                372                691                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.534              (e)              P=0.126            P=0.489              (e)                |
|INCIDENTAL TUMOR       |        P=0.627              (e)              P=0.089            P=0.705              (e)                |
|LOGISTIC REGRESSION    |        P=0.564              (e)              P=0.121            P=0.493              (e)                |
|COCHRAN-ARMITAGE       |        P=0.600                                                                                          |
|FISHER EXACT           |                             (e)              P=0.123            P=0.500              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          2/80 (3%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               3.3%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                372                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.612N             (e)              P=0.253              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.623N             (e)              P=0.113              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.620N             (e)              P=0.232              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.675N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.248              (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  29
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          3/80 (4%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               6.3%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                372                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.644N             (e)              P=0.126              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.588N             (e)              P=0.089              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.625N             (e)              P=0.121              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.617N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.123              (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  30
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/80 (1%)          0/81 (0%)          0/80 (0%)          1/80 (1%)          0/30 (0%)            |
|ADJUSTED (b)           |         2.9%               0.0%               0.0%               3.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        1/34 (3%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                722                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.723            P=0.478N           P=0.525N           P=0.705              (e)                |
|INCIDENTAL TUMOR       |        P=0.823            P=0.478N           P=0.525N           P=0.691N             (e)                |
|LOGISTIC REGRESSION    |        P=0.745            P=0.478N           P=0.525N           P=0.736              (e)                |
|COCHRAN-ARMITAGE       |        P=0.675N                                                                                         |
|FISHER EXACT           |                           P=0.497N           P=0.500N           P=0.752N           P=0.727N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          0/81 (0%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  31
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |                                                                                                         |
|ADJUSTED (b)           |                                                                                                         |
|INTERIM SACRIFICE 1 (c)|                                                                                                         |
|INTERIM SACRIFICE 2 (c)|                                                                                                         |
|INTERIM SACRIFICE 3 (c)|                                                                                                         |
|TERMINAL (d)           |                                                                                                         |
|FIRST INCIDENCE (DAYS) |                                                                                                         |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |                                                                                                         |
|INCIDENTAL TUMOR       |                                                                                                         |
|LOGISTIC REGRESSION    |                                                                                                         |
|COCHRAN-ARMITAGE       |                                                                                                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       10/80 (13%)         8/81 (10%)         3/80 (4%)         11/80 (14%)         0/30 (0%)            |
|ADJUSTED (b)           |        23.7%              19.9%               7.5%              34.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        1/9 (11%)          1/8 (13%)          1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        5/34 (15%)         7/38 (18%)         1/30 (3%)          6/26 (23%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            456 (I)            456 (I)            670                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.499            P=0.335N           P=0.047N*          P=0.345            P=0.500N             |
|INCIDENTAL TUMOR       |        P=0.481N           P=0.434N           P=0.052N           P=0.515            P=0.284N             |
|LOGISTIC REGRESSION    |        P=0.547N           P=0.354N           P=0.035N*          P=0.472            P=0.280N             |
|COCHRAN-ARMITAGE       |        P=0.141N                                                                                         |
|FISHER EXACT           |                           P=0.391N           P=0.040N*          P=0.500            P=0.035N*            |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  32
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       10/80 (13%)         8/81 (10%)         3/80 (4%)         12/80 (15%)         0/30 (0%)            |
|ADJUSTED (b)           |        23.7%              19.9%               7.5%              37.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        1/9 (11%)          1/8 (13%)          1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        5/34 (15%)         7/38 (18%)         1/30 (3%)          7/26 (27%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            456 (I)            456 (I)            670                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.391            P=0.335N           P=0.047N*          P=0.258            P=0.500N             |
|INCIDENTAL TUMOR       |        P=0.587            P=0.434N           P=0.052N           P=0.403            P=0.284N             |
|LOGISTIC REGRESSION    |        P=0.530            P=0.354N           P=0.035N*          P=0.377            P=0.280N             |
|COCHRAN-ARMITAGE       |        P=0.179N                                                                                         |
|FISHER EXACT           |                           P=0.391N           P=0.040N*          P=0.409            P=0.035N*            |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          1/81 (1%)          2/80 (3%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               2.6%               5.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          1/38 (3%)          1/30 (3%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            456 (I)            ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.592N           P=0.522            P=0.237              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.592N           P=0.522            P=0.237              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.641N           P=0.522            P=0.242              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.516N                                                                                         |
|FISHER EXACT           |                           P=0.503            P=0.248              (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  33
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        7/80 (9%)          2/81 (2%)          8/80 (10%)         9/80 (11%)         1/30 (3%)            |
|ADJUSTED (b)           |        18.4%               4.3%              23.8%              30.4%              11.1%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        1/9 (11%)          1/8 (13%)          0/10 (0%)          0/10 (0%)          1/9 (11%)            |
|TERMINAL (d)           |        5/34 (15%)         1/38 (3%)          6/30 (20%)         7/26 (27%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            456 (I)            619                550                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.063            P=0.070N           P=0.444            P=0.245            P=0.767              |
|INCIDENTAL TUMOR       |        P=0.097            P=0.065N           P=0.520            P=0.321            P=0.767              |
|LOGISTIC REGRESSION    |        P=0.095            P=0.072N           P=0.544            P=0.366            P=0.594              |
|COCHRAN-ARMITAGE       |        P=0.557                                                                                          |
|FISHER EXACT           |                           P=0.081N           P=0.500            P=0.397            P=0.303N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          2/81 (2%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               4.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          0/38 (0%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                397                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.549N           P=0.260              (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.492N           P=0.196              (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.446N           P=0.241              (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.429N                                                                                         |
|FISHER EXACT           |                           P=0.252              (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  34
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/80 (0%)          2/81 (2%)          0/80 (0%)          0/80 (0%)          0/30 (0%)            |
|ADJUSTED (b)           |         0.0%               4.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        0/34 (0%)          1/38 (3%)          0/30 (0%)          0/26 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                222                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.541N           P=0.254              (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.551N           P=0.368              (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.412N           P=0.240              (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.429N                                                                                         |
|FISHER EXACT           |                           P=0.252              (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        8/80 (10%)         8/81 (10%)        13/80 (16%)        15/80 (19%)         0/30 (0%)            |
|ADJUSTED (b)           |        22.7%              18.9%              29.6%              39.2%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           0/10 (0%)          0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |        7/34 (21%)         5/38 (13%)         3/30 (10%)         5/26 (19%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         675                464                592                546                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.016 *          P=0.512N           P=0.174            P=0.041 *            (e)                |
|INCIDENTAL TUMOR       |        P=0.144            P=0.518N           P=0.320            P=0.151              (e)                |
|LOGISTIC REGRESSION    |        P=0.093            P=0.535N           P=0.434            P=0.064            P=1.000N             |
|COCHRAN-ARMITAGE       |        P=0.376N                                                                                         |
|FISHER EXACT           |                           P=0.593N           P=0.175            P=0.088            P=0.071N             |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  35
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       47/80 (59%)        36/81 (44%)        42/80 (53%)        44/80 (55%)         4/30 (13%)           |
|ADJUSTED (b)           |        94.0%              71.4%              85.5%              93.4%              44.4%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        2/9 (22%)          3/8 (38%)          4/10 (40%)         2/10 (20%)         4/9 (44%)            |
|TERMINAL (d)           |       31/34 (91%)        24/38 (63%)        23/30 (77%)        23/26 (88%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)             92 (I)            456 (I)            353                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.074            P=0.013N*          P=0.394N           P=0.291            P=0.314              |
|INCIDENTAL TUMOR       |        P=0.501            P=0.012N*          P=0.043N*          P=0.346N           P=0.465              |
|LOGISTIC REGRESSION    |        P=0.419            P=0.007N**         P=0.068N           P=0.365N           P=0.475              |
|COCHRAN-ARMITAGE       |        P=0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.048N*          P=0.262N           P=0.375N           P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       14/80 (18%)        16/81 (20%)        18/80 (23%)        20/80 (25%)         0/30 (0%)            |
|ADJUSTED (b)           |        34.8%              32.4%              37.9%              49.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        0/9 (0%)           0/8 (0%)           1/10 (10%)         0/10 (0%)          0/9 (0%)             |
|TERMINAL (d)           |       10/34 (29%)         7/38 (18%)         4/30 (13%)         7/26 (27%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         274 (I)            222                372                546                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.152            P=0.530            P=0.269            P=0.077            P=0.406N             |
|INCIDENTAL TUMOR       |        P=0.535            P=0.510            P=0.297            P=0.183            P=0.284N             |
|LOGISTIC REGRESSION    |        P=0.541N           P=0.461            P=0.309            P=0.133            P=0.218N             |
|COCHRAN-ARMITAGE       |        P=0.102N                                                                                         |
|FISHER EXACT           |                           P=0.435            P=0.277            P=0.167            P=0.008N**           |
|=================================================================================================================================|
         DATE: 11/10/95                     EXPERIMENT: 05100 TEST: 03                                                 PAGE  36
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- TRICRESYL PHOSPHATE

                       TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|DOSE                   |         0 PPM              75 PPM             150 PPM            300 PPM            600 PPM             |
|                       |                                                                                     23 STOP             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       50/80 (63%)        44/81 (54%)        48/80 (60%)        48/80 (60%)         4/30 (13%)           |
|ADJUSTED (b)           |        96.1%              79.5%              88.7%              96.0%              44.4%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         1/10 (10%)         0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 3 (c)|        2/9 (22%)          3/8 (38%)          5/10 (50%)         2/10 (20%)         4/9 (44%)            |
|TERMINAL (d)           |       32/34 (94%)        27/38 (71%)        24/30 (80%)        24/26 (92%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         274 (I)             92 (I)            372                353                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.139            P=0.082N           P=0.550            P=0.227            P=0.548              |
|INCIDENTAL TUMOR       |        P=0.446N           P=0.121N           P=0.251N           P=0.520N           P=0.626N             |
|LOGISTIC REGRESSION    |        P=0.376N           P=0.094N           P=0.239N           P=0.477N           P=0.507N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.186N           P=0.436N           P=0.436N           P<0.001N**           |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   92  273  455
          Female interim sacrifices(days): 92  274  456
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).